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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide association study identifies five loci associated with lung function</title><author><name sortKey="Repapi, Emmanouela" sort="Repapi, Emmanouela" uniqKey="Repapi E" first="Emmanouela" last="Repapi">Emmanouela Repapi</name><affiliation><nlm:aff id="A1">Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK.</nlm:aff></affiliation></author><author><name sortKey="Sayers, Ian" sort="Sayers, Ian" uniqKey="Sayers I" first="Ian" last="Sayers">Ian Sayers</name><affiliation><nlm:aff id="A2">Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Wain, Louise V" sort="Wain, Louise V" uniqKey="Wain L" first="Louise V" last="Wain">Louise V. Wain</name><affiliation><nlm:aff id="A1">Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK.</nlm:aff></affiliation></author><author><name sortKey="Burton, Paul R" sort="Burton, Paul R" uniqKey="Burton P" first="Paul R" last="Burton">Paul R. Burton</name><affiliation><nlm:aff id="A1">Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK.</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A3">Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Obeidat, Ma N" sort="Obeidat, Ma N" uniqKey="Obeidat M" first="Ma N" last="Obeidat">Ma N Obeidat</name><affiliation><nlm:aff id="A2">Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A4">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name><affiliation><nlm:aff id="A5">Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Department of Epidemiology and Public Health, Imperial College London, St. Mary’s Campus, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Zhai, Guangju" sort="Zhai, Guangju" uniqKey="Zhai G" first="Guangju" last="Zhai">Guangju Zhai</name><affiliation><nlm:aff id="A7">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="A8">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E" last="Huffman">Jennifer E. Huffman</name><affiliation><nlm:aff id="A8">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation><nlm:aff id="A9">Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Albrecht, Eva" sort="Albrecht, Eva" uniqKey="Albrecht E" first="Eva" last="Albrecht">Eva Albrecht</name><affiliation><nlm:aff id="A10">Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A11">Wellcome Trust Sanger Institute, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Henderson, John" sort="Henderson, John" uniqKey="Henderson J" first="John" last="Henderson">John Henderson</name><affiliation><nlm:aff id="A12">Department of Community-Based Medicine, University of Bristol, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Granell, Raquel" sort="Granell, Raquel" uniqKey="Granell R" first="Raquel" last="Granell">Raquel Granell</name><affiliation><nlm:aff id="A13">Department of Social Medicine, University of Bristol, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A14">Avon Longitudinal Study of Parents and Children (ALSPAC) Laboratory, Department of Social Medicine, University of Bristol, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Rudnicka, Alicja R" sort="Rudnicka, Alicja R" uniqKey="Rudnicka A" first="Alicja R" last="Rudnicka">Alicja R. Rudnicka</name><affiliation><nlm:aff id="A15">Division of Community Health Sciences, St. George’s University of London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Barroso, Ines" sort="Barroso, Ines" uniqKey="Barroso I" first="Inês" last="Barroso">Inês Barroso</name><affiliation><nlm:aff id="A11">Wellcome Trust Sanger Institute, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J F" last="Loos">Ruth J F. Loos</name><affiliation><nlm:aff id="A4">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A4">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Mustelin, Linda" sort="Mustelin, Linda" uniqKey="Mustelin L" first="Linda" last="Mustelin">Linda Mustelin</name><affiliation><nlm:aff id="A17">Department of Public Health, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Rantanen, Taina" sort="Rantanen, Taina" uniqKey="Rantanen T" first="Taina" last="Rantanen">Taina Rantanen</name><affiliation><nlm:aff id="A18">Department of Health Sciences and Finnish Center for Interdisciplinary Gerontology, University of Jyväskylä, Jyväskylä, Finland.</nlm:aff></affiliation></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation><nlm:aff id="A19">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">National Institute for Health and Welfare, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name><affiliation><nlm:aff id="A21">Department of Chronic Disease Epidemiology/NICER, Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H Erich" last="Wichmann">H Erich Wichmann</name><affiliation><nlm:aff id="A10">Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Klinikum Grosshadern, Munich, Germany.</nlm:aff></affiliation></author><author><name sortKey="Grkovic, Ivica" sort="Grkovic, Ivica" uniqKey="Grkovic I" first="Ivica" last="Grkovic">Ivica Grkovic</name><affiliation><nlm:aff id="A24">Croatian Centre for Global Health, The University of Split Medical School, Split, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Jankovic, Stipan" sort="Jankovic, Stipan" uniqKey="Jankovic S" first="Stipan" last="Jankovic">Stipan Jankovic</name><affiliation><nlm:aff id="A24">Croatian Centre for Global Health, The University of Split Medical School, Split, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name><affiliation><nlm:aff id="A25">Andrija Stampar School of Public Health, Faculty of Medicine, University of Zagreb, Zagreb, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A26">Department of Clinical Sciences, Obstetrics and Gynecology, Institute of Clinical Medicine, University of Oulu, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Peltonen, Leena" sort="Peltonen, Leena" uniqKey="Peltonen L" first="Leena" last="Peltonen">Leena Peltonen</name><affiliation><nlm:aff id="A11">Wellcome Trust Sanger Institute, Cambridge, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">National Institute for Health and Welfare, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="A9">Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="A9">Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Zaboli, Ghazal" sort="Zaboli, Ghazal" uniqKey="Zaboli G" first="Ghazal" last="Zaboli">Ghazal Zaboli</name><affiliation><nlm:aff id="A9">Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A27">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H" last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A27">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A27">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Gl Ser, Sven" sort="Gl Ser, Sven" uniqKey="Gl Ser S" first="Sven" last="Gl Ser">Sven Gl Ser</name><affiliation><nlm:aff id="A28">Department of Internal Medicine B–Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University of Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><nlm:aff id="A29">Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:aff id="A30">Institute for Community Medicine, SHIP/Clinical-Epidemiological Research, University of Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="A7">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:aff id="A7">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Wellcome Trust Sanger Institute, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation><nlm:aff id="A7">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polašek">Ozren Polašek</name><affiliation><nlm:aff id="A25">Andrija Stampar School of Public Health, Faculty of Medicine, University of Zagreb, Zagreb, Croatia.</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Gen-Info, Zagreb, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A24">Croatian Centre for Global Health, The University of Split Medical School, Split, Croatia.</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Gen-Info, Zagreb, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F" last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="A8">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Heliovaara, Markku" sort="Heliovaara, Markku" uniqKey="Heliovaara M" first="Markku" last="Heliövaara">Markku Heliövaara</name><affiliation><nlm:aff id="A20">National Institute for Health and Welfare, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation><nlm:aff id="A19">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">National Institute for Health and Welfare, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A32">Department of Lifecourse and Services, National Institute for Health and Welfare, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Naluai, Sa Torinsson" sort="Naluai, Sa Torinsson" uniqKey="Naluai " first=" Sa Torinsson" last="Naluai"> Sa Torinsson Naluai</name><affiliation><nlm:aff id="A33">Department of Microbiology and Immunology, Institute of Biomedicine.</nlm:aff></affiliation></author><author><name sortKey="Olin, Anna Carin" sort="Olin, Anna Carin" uniqKey="Olin A" first="Anna-Carin" last="Olin">Anna-Carin Olin</name><affiliation><nlm:aff id="A34">Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Toren, Kjell" sort="Toren, Kjell" uniqKey="Toren K" first="Kjell" last="Torén">Kjell Torén</name><affiliation><nlm:aff id="A34">Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Cooper, Matthew N" sort="Cooper, Matthew N" uniqKey="Cooper M" first="Matthew N" last="Cooper">Matthew N. Cooper</name><affiliation><nlm:aff id="A35">Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Perth, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="James, Alan L" sort="James, Alan L" uniqKey="James A" first="Alan L" last="James">Alan L. James</name><affiliation><nlm:aff id="A36">Department of Pulmonary Physiology/West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A35">Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Perth, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. Hingorani</name><affiliation><nlm:aff id="A38">Department of Epidemiology and Public Health, University College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Wannamethee, S Goya" sort="Wannamethee, S Goya" uniqKey="Wannamethee S" first="S Goya" last="Wannamethee">S Goya Wannamethee</name><affiliation><nlm:aff id="A39">Department of Primary Care and Population Health, University College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Whincup, Peter H" sort="Whincup, Peter H" uniqKey="Whincup P" first="Peter H" last="Whincup">Peter H. Whincup</name><affiliation><nlm:aff id="A15">Division of Community Health Sciences, St. George’s University of London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation><nlm:aff id="A40">MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Ebrahim, Shah" sort="Ebrahim, Shah" uniqKey="Ebrahim S" first="Shah" last="Ebrahim">Shah Ebrahim</name><affiliation><nlm:aff id="A41">Non-Communicable Diseases Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Mckeever, Tricia M" sort="Mckeever, Tricia M" uniqKey="Mckeever T" first="Tricia M" last="Mckeever">Tricia M. Mckeever</name><affiliation><nlm:aff id="A42">Division of Epidemiology and Public Health, School of Community Health Sciences, University of Nottingham, Nottingham, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Pavord, Ian D" sort="Pavord, Ian D" uniqKey="Pavord I" first="Ian D" last="Pavord">Ian D. Pavord</name><affiliation><nlm:aff id="A44">Institute for Lung Health, Glenfield Hospital, University Hospitals of Leicester National Health Service Trust, Leicester, UK.</nlm:aff></affiliation></author><author><name sortKey="Macleod, Andrew K" sort="Macleod, Andrew K" uniqKey="Macleod A" first="Andrew K" last="Macleod">Andrew K. Macleod</name><affiliation><nlm:aff id="A45">Medical Genetics Section, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew D" sort="Morris, Andrew D" uniqKey="Morris A" first="Andrew D" last="Morris">Andrew D. Morris</name><affiliation><nlm:aff id="A46">Biomedical Research Institute, Ninewells Hospital, University of Dundee, Dundee, UK.</nlm:aff></affiliation></author><author><name sortKey="Porteous, David J" sort="Porteous, David J" uniqKey="Porteous D" first="David J" last="Porteous">David J. Porteous</name><affiliation><nlm:aff id="A45">Medical Genetics Section, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.</nlm:aff></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation><nlm:aff id="A47">MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A48">National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Dennison, Elaine" sort="Dennison, Elaine" uniqKey="Dennison E" first="Elaine" last="Dennison">Elaine Dennison</name><affiliation><nlm:aff id="A47">MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK.</nlm:aff></affiliation></author><author><name sortKey="Shaheen, Seif" sort="Shaheen, Seif" uniqKey="Shaheen S" first="Seif" last="Shaheen">Seif Shaheen</name><affiliation><nlm:aff id="A5">Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Karrasch, Stefan" sort="Karrasch, Stefan" uniqKey="Karrasch S" first="Stefan" last="Karrasch">Stefan Karrasch</name><affiliation><nlm:aff id="A49">Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Schnabel, Eva" sort="Schnabel, Eva" uniqKey="Schnabel E" first="Eva" last="Schnabel">Eva Schnabel</name><affiliation><nlm:aff id="A10">Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Schulz, Holger" sort="Schulz, Holger" uniqKey="Schulz H" first="Holger" last="Schulz">Holger Schulz</name><affiliation><nlm:aff id="A49">Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation><nlm:aff id="A10">Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation><nlm:aff id="A50">CNRS 8090–Institute of Biology, Pasteur Institute, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Delplanque, Jerome" sort="Delplanque, Jerome" uniqKey="Delplanque J" first="Jérôme" last="Delplanque">Jérôme Delplanque</name><affiliation><nlm:aff id="A50">CNRS 8090–Institute of Biology, Pasteur Institute, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A50">CNRS 8090–Institute of Biology, Pasteur Institute, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Section of Genomic Medicine, Imperial College London, Hammersmith Hospital, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Blakey, John D" sort="Blakey, John D" uniqKey="Blakey J" first="John D" last="Blakey">John D. Blakey</name><affiliation><nlm:aff id="A2">Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Britton, John R" sort="Britton, John R" uniqKey="Britton J" first="John R" last="Britton">John R. Britton</name><affiliation><nlm:aff id="A42">Division of Epidemiology and Public Health, School of Community Health Sciences, University of Nottingham, Nottingham, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Morris, Richard W" sort="Morris, Richard W" uniqKey="Morris R" first="Richard W" last="Morris">Richard W. Morris</name><affiliation><nlm:aff id="A39">Department of Primary Care and Population Health, University College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Holloway, John W" sort="Holloway, John W" uniqKey="Holloway J" first="John W" last="Holloway">John W. Holloway</name><affiliation><nlm:aff id="A54">Human Genetics Division University of Southampton, Southampton General Hospital, Southampton, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Infection, Inflammation and Immunity Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.</nlm:aff></affiliation></author><author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name><affiliation><nlm:aff id="A40">MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Hui, Jennie" sort="Hui, Jennie" uniqKey="Hui J" first="Jennie" last="Hui">Jennie Hui</name><affiliation><nlm:aff id="A37">Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Molecular Genetics, PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Nyberg, Fredrik" sort="Nyberg, Fredrik" uniqKey="Nyberg F" first="Fredrik" last="Nyberg">Fredrik Nyberg</name><affiliation><nlm:aff id="A34">Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A57">AstraZeneca Research and Development, Mölndal, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A6">Department of Epidemiology and Public Health, Imperial College London, St. Mary’s Campus, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Department of Lifecourse and Services, National Institute for Health and Welfare, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Institute of Health Sciences, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Biocenter Oulu, University of Oulu, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Jackson, Cathy" sort="Jackson, Cathy" uniqKey="Jackson C" first="Cathy" last="Jackson">Cathy Jackson</name><affiliation><nlm:aff id="A60">Bute Medical School, University of St. Andrews, St. Andrews, Fife, UK.</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A61">Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation><nlm:aff id="A17">Department of Public Health, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">National Institute for Health and Welfare, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M" last="Probst-Hensch">Nicole M. Probst-Hensch</name><affiliation><nlm:aff id="A21">Department of Chronic Disease Epidemiology/NICER, Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Institute of Social and Preventive Medicine at Swiss Tropical Institute, University of Basel, Basel, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Koch, Beate" sort="Koch, Beate" uniqKey="Koch B" first="Beate" last="Koch">Beate Koch</name><affiliation><nlm:aff id="A28">Department of Internal Medicine B–Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University of Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A8">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name><affiliation><nlm:aff id="A40">MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="A6">Department of Epidemiology and Public Health, Imperial College London, St. Mary’s Campus, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A63">MRC–Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="A15">Division of Community Health Sciences, St. George’s University of London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Hall, Ian P" sort="Hall, Ian P" uniqKey="Hall I" first="Ian P" last="Hall">Ian P. Hall</name><affiliation><nlm:aff id="A2">Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Tobin, Martin D" sort="Tobin, Martin D" uniqKey="Tobin M" first="Martin D" last="Tobin">Martin D. Tobin</name><affiliation><nlm:aff id="A1">Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20010834</idno><idno type="pmc">2862965</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862965</idno><idno type="RBID">PMC:2862965</idno><idno type="doi">10.1038/ng.501</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">002126</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002126</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association study identifies five loci associated with lung function</title><author><name sortKey="Repapi, Emmanouela" sort="Repapi, Emmanouela" uniqKey="Repapi E" first="Emmanouela" last="Repapi">Emmanouela Repapi</name><affiliation><nlm:aff id="A1">Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK.</nlm:aff></affiliation></author><author><name sortKey="Sayers, Ian" sort="Sayers, Ian" uniqKey="Sayers I" first="Ian" last="Sayers">Ian Sayers</name><affiliation><nlm:aff id="A2">Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Wain, Louise V" sort="Wain, Louise V" uniqKey="Wain L" first="Louise V" last="Wain">Louise V. Wain</name><affiliation><nlm:aff id="A1">Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK.</nlm:aff></affiliation></author><author><name sortKey="Burton, Paul R" sort="Burton, Paul R" uniqKey="Burton P" first="Paul R" last="Burton">Paul R. Burton</name><affiliation><nlm:aff id="A1">Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK.</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A3">Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Obeidat, Ma N" sort="Obeidat, Ma N" uniqKey="Obeidat M" first="Ma N" last="Obeidat">Ma N Obeidat</name><affiliation><nlm:aff id="A2">Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A4">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name><affiliation><nlm:aff id="A5">Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Department of Epidemiology and Public Health, Imperial College London, St. Mary’s Campus, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Zhai, Guangju" sort="Zhai, Guangju" uniqKey="Zhai G" first="Guangju" last="Zhai">Guangju Zhai</name><affiliation><nlm:aff id="A7">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation><nlm:aff id="A8">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E" last="Huffman">Jennifer E. Huffman</name><affiliation><nlm:aff id="A8">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation><nlm:aff id="A9">Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Albrecht, Eva" sort="Albrecht, Eva" uniqKey="Albrecht E" first="Eva" last="Albrecht">Eva Albrecht</name><affiliation><nlm:aff id="A10">Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A11">Wellcome Trust Sanger Institute, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Henderson, John" sort="Henderson, John" uniqKey="Henderson J" first="John" last="Henderson">John Henderson</name><affiliation><nlm:aff id="A12">Department of Community-Based Medicine, University of Bristol, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Granell, Raquel" sort="Granell, Raquel" uniqKey="Granell R" first="Raquel" last="Granell">Raquel Granell</name><affiliation><nlm:aff id="A13">Department of Social Medicine, University of Bristol, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A14">Avon Longitudinal Study of Parents and Children (ALSPAC) Laboratory, Department of Social Medicine, University of Bristol, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Rudnicka, Alicja R" sort="Rudnicka, Alicja R" uniqKey="Rudnicka A" first="Alicja R" last="Rudnicka">Alicja R. Rudnicka</name><affiliation><nlm:aff id="A15">Division of Community Health Sciences, St. George’s University of London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Barroso, Ines" sort="Barroso, Ines" uniqKey="Barroso I" first="Inês" last="Barroso">Inês Barroso</name><affiliation><nlm:aff id="A11">Wellcome Trust Sanger Institute, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J F" last="Loos">Ruth J F. Loos</name><affiliation><nlm:aff id="A4">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A4">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Mustelin, Linda" sort="Mustelin, Linda" uniqKey="Mustelin L" first="Linda" last="Mustelin">Linda Mustelin</name><affiliation><nlm:aff id="A17">Department of Public Health, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Rantanen, Taina" sort="Rantanen, Taina" uniqKey="Rantanen T" first="Taina" last="Rantanen">Taina Rantanen</name><affiliation><nlm:aff id="A18">Department of Health Sciences and Finnish Center for Interdisciplinary Gerontology, University of Jyväskylä, Jyväskylä, Finland.</nlm:aff></affiliation></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation><nlm:aff id="A19">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">National Institute for Health and Welfare, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name><affiliation><nlm:aff id="A21">Department of Chronic Disease Epidemiology/NICER, Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H Erich" last="Wichmann">H Erich Wichmann</name><affiliation><nlm:aff id="A10">Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Klinikum Grosshadern, Munich, Germany.</nlm:aff></affiliation></author><author><name sortKey="Grkovic, Ivica" sort="Grkovic, Ivica" uniqKey="Grkovic I" first="Ivica" last="Grkovic">Ivica Grkovic</name><affiliation><nlm:aff id="A24">Croatian Centre for Global Health, The University of Split Medical School, Split, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Jankovic, Stipan" sort="Jankovic, Stipan" uniqKey="Jankovic S" first="Stipan" last="Jankovic">Stipan Jankovic</name><affiliation><nlm:aff id="A24">Croatian Centre for Global Health, The University of Split Medical School, Split, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name><affiliation><nlm:aff id="A25">Andrija Stampar School of Public Health, Faculty of Medicine, University of Zagreb, Zagreb, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A26">Department of Clinical Sciences, Obstetrics and Gynecology, Institute of Clinical Medicine, University of Oulu, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Peltonen, Leena" sort="Peltonen, Leena" uniqKey="Peltonen L" first="Leena" last="Peltonen">Leena Peltonen</name><affiliation><nlm:aff id="A11">Wellcome Trust Sanger Institute, Cambridge, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">National Institute for Health and Welfare, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name><affiliation><nlm:aff id="A9">Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name><affiliation><nlm:aff id="A9">Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Zaboli, Ghazal" sort="Zaboli, Ghazal" uniqKey="Zaboli G" first="Ghazal" last="Zaboli">Ghazal Zaboli</name><affiliation><nlm:aff id="A9">Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:aff id="A27">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H" last="Wild">Sarah H. Wild</name><affiliation><nlm:aff id="A27">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation><nlm:aff id="A27">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Gl Ser, Sven" sort="Gl Ser, Sven" uniqKey="Gl Ser S" first="Sven" last="Gl Ser">Sven Gl Ser</name><affiliation><nlm:aff id="A28">Department of Internal Medicine B–Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University of Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><nlm:aff id="A29">Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:aff id="A30">Institute for Community Medicine, SHIP/Clinical-Epidemiological Research, University of Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="A7">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:aff id="A7">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Wellcome Trust Sanger Institute, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation><nlm:aff id="A7">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polašek">Ozren Polašek</name><affiliation><nlm:aff id="A25">Andrija Stampar School of Public Health, Faculty of Medicine, University of Zagreb, Zagreb, Croatia.</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Gen-Info, Zagreb, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:aff id="A24">Croatian Centre for Global Health, The University of Split Medical School, Split, Croatia.</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Gen-Info, Zagreb, Croatia.</nlm:aff></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F" last="Wright">Alan F. Wright</name><affiliation><nlm:aff id="A8">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Heliovaara, Markku" sort="Heliovaara, Markku" uniqKey="Heliovaara M" first="Markku" last="Heliövaara">Markku Heliövaara</name><affiliation><nlm:aff id="A20">National Institute for Health and Welfare, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name><affiliation><nlm:aff id="A19">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">National Institute for Health and Welfare, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A32">Department of Lifecourse and Services, National Institute for Health and Welfare, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Naluai, Sa Torinsson" sort="Naluai, Sa Torinsson" uniqKey="Naluai " first=" Sa Torinsson" last="Naluai"> Sa Torinsson Naluai</name><affiliation><nlm:aff id="A33">Department of Microbiology and Immunology, Institute of Biomedicine.</nlm:aff></affiliation></author><author><name sortKey="Olin, Anna Carin" sort="Olin, Anna Carin" uniqKey="Olin A" first="Anna-Carin" last="Olin">Anna-Carin Olin</name><affiliation><nlm:aff id="A34">Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Toren, Kjell" sort="Toren, Kjell" uniqKey="Toren K" first="Kjell" last="Torén">Kjell Torén</name><affiliation><nlm:aff id="A34">Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Cooper, Matthew N" sort="Cooper, Matthew N" uniqKey="Cooper M" first="Matthew N" last="Cooper">Matthew N. Cooper</name><affiliation><nlm:aff id="A35">Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Perth, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="James, Alan L" sort="James, Alan L" uniqKey="James A" first="Alan L" last="James">Alan L. James</name><affiliation><nlm:aff id="A36">Department of Pulmonary Physiology/West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A35">Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Perth, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. Hingorani</name><affiliation><nlm:aff id="A38">Department of Epidemiology and Public Health, University College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Wannamethee, S Goya" sort="Wannamethee, S Goya" uniqKey="Wannamethee S" first="S Goya" last="Wannamethee">S Goya Wannamethee</name><affiliation><nlm:aff id="A39">Department of Primary Care and Population Health, University College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Whincup, Peter H" sort="Whincup, Peter H" uniqKey="Whincup P" first="Peter H" last="Whincup">Peter H. Whincup</name><affiliation><nlm:aff id="A15">Division of Community Health Sciences, St. George’s University of London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation><nlm:aff id="A40">MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Ebrahim, Shah" sort="Ebrahim, Shah" uniqKey="Ebrahim S" first="Shah" last="Ebrahim">Shah Ebrahim</name><affiliation><nlm:aff id="A41">Non-Communicable Diseases Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Mckeever, Tricia M" sort="Mckeever, Tricia M" uniqKey="Mckeever T" first="Tricia M" last="Mckeever">Tricia M. Mckeever</name><affiliation><nlm:aff id="A42">Division of Epidemiology and Public Health, School of Community Health Sciences, University of Nottingham, Nottingham, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Pavord, Ian D" sort="Pavord, Ian D" uniqKey="Pavord I" first="Ian D" last="Pavord">Ian D. Pavord</name><affiliation><nlm:aff id="A44">Institute for Lung Health, Glenfield Hospital, University Hospitals of Leicester National Health Service Trust, Leicester, UK.</nlm:aff></affiliation></author><author><name sortKey="Macleod, Andrew K" sort="Macleod, Andrew K" uniqKey="Macleod A" first="Andrew K" last="Macleod">Andrew K. Macleod</name><affiliation><nlm:aff id="A45">Medical Genetics Section, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.</nlm:aff></affiliation></author><author><name sortKey="Morris, Andrew D" sort="Morris, Andrew D" uniqKey="Morris A" first="Andrew D" last="Morris">Andrew D. Morris</name><affiliation><nlm:aff id="A46">Biomedical Research Institute, Ninewells Hospital, University of Dundee, Dundee, UK.</nlm:aff></affiliation></author><author><name sortKey="Porteous, David J" sort="Porteous, David J" uniqKey="Porteous D" first="David J" last="Porteous">David J. Porteous</name><affiliation><nlm:aff id="A45">Medical Genetics Section, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.</nlm:aff></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation><nlm:aff id="A47">MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A48">National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Dennison, Elaine" sort="Dennison, Elaine" uniqKey="Dennison E" first="Elaine" last="Dennison">Elaine Dennison</name><affiliation><nlm:aff id="A47">MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK.</nlm:aff></affiliation></author><author><name sortKey="Shaheen, Seif" sort="Shaheen, Seif" uniqKey="Shaheen S" first="Seif" last="Shaheen">Seif Shaheen</name><affiliation><nlm:aff id="A5">Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Karrasch, Stefan" sort="Karrasch, Stefan" uniqKey="Karrasch S" first="Stefan" last="Karrasch">Stefan Karrasch</name><affiliation><nlm:aff id="A49">Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Schnabel, Eva" sort="Schnabel, Eva" uniqKey="Schnabel E" first="Eva" last="Schnabel">Eva Schnabel</name><affiliation><nlm:aff id="A10">Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Schulz, Holger" sort="Schulz, Holger" uniqKey="Schulz H" first="Holger" last="Schulz">Holger Schulz</name><affiliation><nlm:aff id="A49">Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation><nlm:aff id="A10">Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation><nlm:aff id="A50">CNRS 8090–Institute of Biology, Pasteur Institute, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Delplanque, Jerome" sort="Delplanque, Jerome" uniqKey="Delplanque J" first="Jérôme" last="Delplanque">Jérôme Delplanque</name><affiliation><nlm:aff id="A50">CNRS 8090–Institute of Biology, Pasteur Institute, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A50">CNRS 8090–Institute of Biology, Pasteur Institute, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Section of Genomic Medicine, Imperial College London, Hammersmith Hospital, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Blakey, John D" sort="Blakey, John D" uniqKey="Blakey J" first="John D" last="Blakey">John D. Blakey</name><affiliation><nlm:aff id="A2">Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Britton, John R" sort="Britton, John R" uniqKey="Britton J" first="John R" last="Britton">John R. Britton</name><affiliation><nlm:aff id="A42">Division of Epidemiology and Public Health, School of Community Health Sciences, University of Nottingham, Nottingham, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Morris, Richard W" sort="Morris, Richard W" uniqKey="Morris R" first="Richard W" last="Morris">Richard W. Morris</name><affiliation><nlm:aff id="A39">Department of Primary Care and Population Health, University College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Holloway, John W" sort="Holloway, John W" uniqKey="Holloway J" first="John W" last="Holloway">John W. Holloway</name><affiliation><nlm:aff id="A54">Human Genetics Division University of Southampton, Southampton General Hospital, Southampton, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Infection, Inflammation and Immunity Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.</nlm:aff></affiliation></author><author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name><affiliation><nlm:aff id="A40">MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Hui, Jennie" sort="Hui, Jennie" uniqKey="Hui J" first="Jennie" last="Hui">Jennie Hui</name><affiliation><nlm:aff id="A37">Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Western Australia, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Molecular Genetics, PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia.</nlm:aff></affiliation></author><author><name sortKey="Nyberg, Fredrik" sort="Nyberg, Fredrik" uniqKey="Nyberg F" first="Fredrik" last="Nyberg">Fredrik Nyberg</name><affiliation><nlm:aff id="A34">Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A57">AstraZeneca Research and Development, Mölndal, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A6">Department of Epidemiology and Public Health, Imperial College London, St. Mary’s Campus, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Department of Lifecourse and Services, National Institute for Health and Welfare, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Institute of Health Sciences, University of Oulu, Oulu, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Biocenter Oulu, University of Oulu, Oulu, Finland.</nlm:aff></affiliation></author><author><name sortKey="Jackson, Cathy" sort="Jackson, Cathy" uniqKey="Jackson C" first="Cathy" last="Jackson">Cathy Jackson</name><affiliation><nlm:aff id="A60">Bute Medical School, University of St. Andrews, St. Andrews, Fife, UK.</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A61">Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.</nlm:aff></affiliation></author><author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name><affiliation><nlm:aff id="A17">Department of Public Health, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">National Institute for Health and Welfare, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M" last="Probst-Hensch">Nicole M. Probst-Hensch</name><affiliation><nlm:aff id="A21">Department of Chronic Disease Epidemiology/NICER, Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Institute of Social and Preventive Medicine at Swiss Tropical Institute, University of Basel, Basel, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Koch, Beate" sort="Koch, Beate" uniqKey="Koch B" first="Beate" last="Koch">Beate Koch</name><affiliation><nlm:aff id="A28">Department of Internal Medicine B–Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University of Greifswald, Greifswald, Germany.</nlm:aff></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:aff id="A8">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.</nlm:aff></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name><affiliation><nlm:aff id="A40">MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="A6">Department of Epidemiology and Public Health, Imperial College London, St. Mary’s Campus, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A63">MRC–Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name><affiliation><nlm:aff id="A15">Division of Community Health Sciences, St. George’s University of London, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Hall, Ian P" sort="Hall, Ian P" uniqKey="Hall I" first="Ian P" last="Hall">Ian P. Hall</name><affiliation><nlm:aff id="A2">Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Tobin, Martin D" sort="Tobin, Martin D" uniqKey="Tobin M" first="Martin D" last="Tobin">Martin D. Tobin</name><affiliation><nlm:aff id="A1">Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK.</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P11">Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV<sub>1</sub>) and the ratio of FEV<sub>1</sub> to forced vital capacity (FVC) in the SpiroMeta consortium (<italic>n</italic> = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (<italic>n</italic> ≤ 32,184 additional individuals) and <italic>in silico</italic> summary association data from the CHARGE Consortium (<italic>n</italic> = 21,209) and the Health 2000 survey (<italic>n</italic> ≤ 883). We confirmed the reported locus at 4q31 and identified associations with FEV<sub>1</sub> or FEV<sub>1</sub>/FVC and common variants at five additional loci: 2q35 in <italic>TNS1</italic> (<italic>P</italic> = 1.11 × 10<sup>−12</sup>), 4q24 in <italic>GSTCD</italic> (2.18 × 10<sup>−23</sup>), 5q33 in <italic>HTR4</italic> (<italic>P</italic> = 4.29 × 10<sup>−9</sup>), 6p21 in <italic>AGER</italic> (<italic>P</italic> = 3.07 × 10<sup>−15</sup>) and 15q23 in <italic>THSD4</italic> (<italic>P</italic> = 7.24 × 10<sup>−15</sup>). mRNA analyses showed expression of <italic>TNS1, GSTCD, AGER, HTR4</italic> and <italic>THSD4</italic> in human lung tissue. These associations offer mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20010834</article-id><article-id pub-id-type="pmc">2862965</article-id><article-id pub-id-type="doi">10.1038/ng.501</article-id><article-id pub-id-type="manuscript">UKMS28778</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Genome-wide association study identifies five loci associated with lung function</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Repapi</surname><given-names>Emmanouela</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="author-notes" rid="FN2">64</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Sayers</surname><given-names>Ian</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FN2">64</xref></contrib><contrib contrib-type="author"><name><surname>Wain</surname><given-names>Louise V</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="author-notes" rid="FN2">64</xref></contrib><contrib contrib-type="author"><name><surname>Burton</surname><given-names>Paul R</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Toby</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Obeidat</surname><given-names>Ma’en</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Jing Hua</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Ramasamy</surname><given-names>Adaikalavan</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Zhai</surname><given-names>Guangju</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Vitart</surname><given-names>Veronique</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Huffman</surname><given-names>Jennifer E</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Igl</surname><given-names>Wilmar</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Albrecht</surname><given-names>Eva</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Deloukas</surname><given-names>Panos</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Henderson</surname><given-names>John</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Granell</surname><given-names>Raquel</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>McArdle</surname><given-names>Wendy L</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Rudnicka</surname><given-names>Alicja R</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><collab>Wellcome Trust Case Control Consortium</collab><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Barroso</surname><given-names>Inês</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Loos</surname><given-names>Ruth J F</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Wareham</surname><given-names>Nicholas J</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Mustelin</surname><given-names>Linda</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Rantanen</surname><given-names>Taina</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Surakka</surname><given-names>Ida</given-names></name><xref ref-type="aff" rid="A19">19</xref><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Imboden</surname><given-names>Medea</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Wichmann</surname><given-names>H Erich</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A22">22</xref><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Grkovic</surname><given-names>Ivica</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Jankovic</surname><given-names>Stipan</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Zgaga</surname><given-names>Lina</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Hartikainen</surname><given-names>Anna-Liisa</given-names></name><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Peltonen</surname><given-names>Leena</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A19">19</xref><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Gyllensten</surname><given-names>Ulf</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Johansson</surname><given-names>Åsa</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Zaboli</surname><given-names>Ghazal</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Campbell</surname><given-names>Harry</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Wild</surname><given-names>Sarah H</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>James F</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Gläser</surname><given-names>Sven</given-names></name><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Homuth</surname><given-names>Georg</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Völzke</surname><given-names>Henry</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Mangino</surname><given-names>Massimo</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Soranzo</surname><given-names>Nicole</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Spector</surname><given-names>Tim D</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Polašek</surname><given-names>Ozren</given-names></name><xref ref-type="aff" rid="A25">25</xref><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Rudan</surname><given-names>Igor</given-names></name><xref ref-type="aff" rid="A24">24</xref><xref ref-type="aff" rid="A27">27</xref><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Wright</surname><given-names>Alan F</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Heliövaara</surname><given-names>Markku</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Ripatti</surname><given-names>Samuli</given-names></name><xref ref-type="aff" rid="A19">19</xref><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Pouta</surname><given-names>Anneli</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Naluai</surname><given-names>Åsa Torinsson</given-names></name><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Olin</surname><given-names>Anna-Carin</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Torén</surname><given-names>Kjell</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Cooper</surname><given-names>Matthew N</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>James</surname><given-names>Alan L</given-names></name><xref ref-type="aff" rid="A36">36</xref><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Palmer</surname><given-names>Lyle J</given-names></name><xref ref-type="aff" rid="A35">35</xref><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Hingorani</surname><given-names>Aroon D</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Wannamethee</surname><given-names>S Goya</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Whincup</surname><given-names>Peter H</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>George Davey</given-names></name><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Ebrahim</surname><given-names>Shah</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>McKeever</surname><given-names>Tricia M</given-names></name><xref ref-type="aff" rid="A42">42</xref><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Pavord</surname><given-names>Ian D</given-names></name><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>MacLeod</surname><given-names>Andrew K</given-names></name><xref ref-type="aff" rid="A45">45</xref></contrib><contrib contrib-type="author"><name><surname>Morris</surname><given-names>Andrew D</given-names></name><xref ref-type="aff" rid="A46">46</xref></contrib><contrib contrib-type="author"><name><surname>Porteous</surname><given-names>David J</given-names></name><xref ref-type="aff" rid="A45">45</xref></contrib><contrib contrib-type="author"><name><surname>Cooper</surname><given-names>Cyrus</given-names></name><xref ref-type="aff" rid="A47">47</xref><xref ref-type="aff" rid="A48">48</xref></contrib><contrib contrib-type="author"><name><surname>Dennison</surname><given-names>Elaine</given-names></name><xref ref-type="aff" rid="A47">47</xref></contrib><contrib contrib-type="author"><name><surname>Shaheen</surname><given-names>Seif</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Karrasch</surname><given-names>Stefan</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Schnabel</surname><given-names>Eva</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Schulz</surname><given-names>Holger</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Grallert</surname><given-names>Harald</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Bouatia-Naji</surname><given-names>Nabila</given-names></name><xref ref-type="aff" rid="A50">50</xref></contrib><contrib contrib-type="author"><name><surname>Delplanque</surname><given-names>Jérôme</given-names></name><xref ref-type="aff" rid="A50">50</xref></contrib><contrib contrib-type="author"><name><surname>Froguel</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="A50">50</xref><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Blakey</surname><given-names>John D</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><collab>The NSHD Respiratory Study Team</collab><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A52">52</xref><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Britton</surname><given-names>John R</given-names></name><xref ref-type="aff" rid="A42">42</xref><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Morris</surname><given-names>Richard W</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Holloway</surname><given-names>John W</given-names></name><xref ref-type="aff" rid="A54">54</xref><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><name><surname>Lawlor</surname><given-names>Debbie A</given-names></name><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Hui</surname><given-names>Jennie</given-names></name><xref ref-type="aff" rid="A37">37</xref><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Nyberg</surname><given-names>Fredrik</given-names></name><xref ref-type="aff" rid="A34">34</xref><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Jarvelin</surname><given-names>Marjo-Riitta</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A32">32</xref><xref ref-type="aff" rid="A58">58</xref><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Jackson</surname><given-names>Cathy</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Kähönen</surname><given-names>Mika</given-names></name><xref ref-type="aff" rid="A61">61</xref></contrib><contrib contrib-type="author"><name><surname>Kaprio</surname><given-names>Jaakko</given-names></name><xref ref-type="aff" rid="A17">17</xref><xref ref-type="aff" rid="A19">19</xref><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Probst-Hensch</surname><given-names>Nicole M</given-names></name><xref ref-type="aff" rid="A21">21</xref><xref ref-type="aff" rid="A62">62</xref></contrib><contrib contrib-type="author"><name><surname>Koch</surname><given-names>Beate</given-names></name><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Hayward</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Evans</surname><given-names>David M</given-names></name><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Elliott</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A63">63</xref><xref ref-type="author-notes" rid="FN2">64</xref></contrib><contrib contrib-type="author"><name><surname>Strachan</surname><given-names>David P</given-names></name><xref ref-type="aff" rid="A15">15</xref><xref ref-type="author-notes" rid="FN2">64</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Ian P</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FN2">64</xref></contrib><contrib contrib-type="author"><name><surname>Tobin</surname><given-names>Martin D</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="author-notes" rid="FN2">64</xref></contrib></contrib-group><aff id="A1"><label>1</label>Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK.</aff><aff id="A2"><label>2</label>Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, UK.</aff><aff id="A3"><label>3</label>Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK.</aff><aff id="A4"><label>4</label>Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.</aff><aff id="A5"><label>5</label>Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK.</aff><aff id="A6"><label>6</label>Department of Epidemiology and Public Health, Imperial College London, St. Mary’s Campus, London, UK.</aff><aff id="A7"><label>7</label>Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.</aff><aff id="A8"><label>8</label>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.</aff><aff id="A9"><label>9</label>Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</aff><aff id="A10"><label>10</label>Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</aff><aff id="A11"><label>11</label>Wellcome Trust Sanger Institute, Cambridge, UK.</aff><aff id="A12"><label>12</label>Department of Community-Based Medicine, University of Bristol, Bristol, UK.</aff><aff id="A13"><label>13</label>Department of Social Medicine, University of Bristol, Bristol, UK.</aff><aff id="A14"><label>14</label>Avon Longitudinal Study of Parents and Children (ALSPAC) Laboratory, Department of Social Medicine, University of Bristol, Bristol, UK.</aff><aff id="A15"><label>15</label>Division of Community Health Sciences, St. George’s University of London, London, UK.</aff><aff id="A16"><label>16</label>A full list of members is provided in the<xref ref-type="supplementary-material" rid="SD2">supplementary Note</xref>.</aff><aff id="A17"><label>17</label>Department of Public Health, University of Helsinki, Helsinki, Finland.</aff><aff id="A18"><label>18</label>Department of Health Sciences and Finnish Center for Interdisciplinary Gerontology, University of Jyväskylä, Jyväskylä, Finland.</aff><aff id="A19"><label>19</label>Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.</aff><aff id="A20"><label>20</label>National Institute for Health and Welfare, Helsinki, Finland.</aff><aff id="A21"><label>21</label>Department of Chronic Disease Epidemiology/NICER, Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland.</aff><aff id="A22"><label>22</label>Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.</aff><aff id="A23"><label>23</label>Klinikum Grosshadern, Munich, Germany.</aff><aff id="A24"><label>24</label>Croatian Centre for Global Health, The University of Split Medical School, Split, Croatia.</aff><aff id="A25"><label>25</label>Andrija Stampar School of Public Health, Faculty of Medicine, University of Zagreb, Zagreb, Croatia.</aff><aff id="A26"><label>26</label>Department of Clinical Sciences, Obstetrics and Gynecology, Institute of Clinical Medicine, University of Oulu, Oulu, Finland.</aff><aff id="A27"><label>27</label>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, UK.</aff><aff id="A28"><label>28</label>Department of Internal Medicine B–Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University of Greifswald, Greifswald, Germany.</aff><aff id="A29"><label>29</label>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.</aff><aff id="A30"><label>30</label>Institute for Community Medicine, SHIP/Clinical-Epidemiological Research, University of Greifswald, Greifswald, Germany.</aff><aff id="A31"><label>31</label>Gen-Info, Zagreb, Croatia.</aff><aff id="A32"><label>32</label>Department of Lifecourse and Services, National Institute for Health and Welfare, Oulu, Finland.</aff><aff id="A33"><label>33</label>Department of Microbiology and Immunology, Institute of Biomedicine.</aff><aff id="A34"><label>34</label>Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</aff><aff id="A35"><label>35</label>Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Perth, Western Australia, Australia.</aff><aff id="A36"><label>36</label>Department of Pulmonary Physiology/West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Western Australia, Australia.</aff><aff id="A37"><label>37</label>Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Western Australia, Australia.</aff><aff id="A38"><label>38</label>Department of Epidemiology and Public Health, University College London, London, UK.</aff><aff id="A39"><label>39</label>Department of Primary Care and Population Health, University College London, London, UK.</aff><aff id="A40"><label>40</label>MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK.</aff><aff id="A41"><label>41</label>Non-Communicable Diseases Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.</aff><aff id="A42"><label>42</label>Division of Epidemiology and Public Health, School of Community Health Sciences, University of Nottingham, Nottingham, UK.</aff><aff id="A43"><label>43</label>Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham, UK.</aff><aff id="A44"><label>44</label>Institute for Lung Health, Glenfield Hospital, University Hospitals of Leicester National Health Service Trust, Leicester, UK.</aff><aff id="A45"><label>45</label>Medical Genetics Section, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.</aff><aff id="A46"><label>46</label>Biomedical Research Institute, Ninewells Hospital, University of Dundee, Dundee, UK.</aff><aff id="A47"><label>47</label>MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK.</aff><aff id="A48"><label>48</label>National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK.</aff><aff id="A49"><label>49</label>Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</aff><aff id="A50"><label>50</label>CNRS 8090–Institute of Biology, Pasteur Institute, Lille, France.</aff><aff id="A51"><label>51</label>Section of Genomic Medicine, Imperial College London, Hammersmith Hospital, London, UK.</aff><aff id="A52"><label>52</label>A full list of members is provided in the<xref ref-type="supplementary-material" rid="SD2">supplementary Note</xref>.</aff><aff id="A53"><label>53</label>MRC National Survey of Health and Development, MRC Unit for Lifelong Health and Ageing, London, UK.</aff><aff id="A54"><label>54</label>Human Genetics Division University of Southampton, Southampton General Hospital, Southampton, UK.</aff><aff id="A55"><label>55</label>Infection, Inflammation and Immunity Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.</aff><aff id="A56"><label>56</label>Molecular Genetics, PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia.</aff><aff id="A57"><label>57</label>AstraZeneca Research and Development, Mölndal, Sweden.</aff><aff id="A58"><label>58</label>Institute of Health Sciences, University of Oulu, Oulu, Finland.</aff><aff id="A59"><label>59</label>Biocenter Oulu, University of Oulu, Oulu, Finland.</aff><aff id="A60"><label>60</label>Bute Medical School, University of St. Andrews, St. Andrews, Fife, UK.</aff><aff id="A61"><label>61</label>Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.</aff><aff id="A62"><label>62</label>Institute of Social and Preventive Medicine at Swiss Tropical Institute, University of Basel, Basel, Switzerland.</aff><aff id="A63"><label>63</label>MRC–Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London, London, UK.</aff><author-notes><corresp id="CR1">Correspondence should be addressed to M.D.T. (<email>mt47@leicester.ac.uk</email>) or I.P.H. (<email>ian.hall@nottingham.ac.uk</email>).
</corresp><fn id="FN1"><label>*</label><p id="P1">A full list of author affiliations appears at the end of the paper.</p></fn><fn fn-type="equal" id="FN2"><label>64</label><p id="P2">These authors contributed equally to this work.</p></fn><fn id="FN3"><p id="P3"><bold>AUTHOR CONTRIBUTIONS</bold> Author contributions are listed in alphabetical order. See <xref ref-type="table" rid="T1">Table 1</xref> for definitions of study acronyms.</p><p id="P4"><bold>Project conception, design and management</bold>. <italic>Stage 1 GWAS, ALSPAC:</italic> J. Henderson, R.G. <italic>B58C:</italic> D.P.S. <italic>EPIC:</italic> I.B., R.J.F.L., N.J.W., J.H.Z. <italic>FTC:</italic> J.K., T.R. <italic>KORA S3:</italic> H.E.W. <italic>Korcula:</italic> H.C., I.G., S.J., I.R., A.F.W., L.Z. <italic>NFBC1966:</italic> P.E., M.-R.J., A.P., L.P. <italic>NSPHS:</italic> U.G. <italic>ORCADES:</italic> H.C., S.H.W., J.F.W., A.F.W. <italic>SHIP:</italic> S.G., G.H., B.K., H.V. <italic>TwinsUK:</italic> T.D.S., G. Zhai. <italic>Vis:</italic> H.C., C.H., O.P., I.R., A.F.W. <italic>Stage 2a follow-up, ADONIX:</italic> A.-C.O., K.T. <italic>BHS:</italic> A.L.J., L.J.P. <italic>GS:SFHS:</italic> H.C., C.J., A.D.M., D.J.P. <italic>HCS:</italic> C.C., E.D., J.W.H. <italic>KORA F4:</italic> S.K, E.S., H.S. <italic>NFBC1986:</italic> A.-L.H., M.-R.J. <italic>Nottingham Smokers:</italic> I.P.H., I. Sayers, M.O. <italic>NSHD:</italic> The NSHD Respiratory Study Team. <italic>Stage 2b in silico follow-up, Health 2000:</italic> M.H., M.K., L.P.</p><p id="P5"><bold>Phenotype collection and data management</bold>. <italic>Stage 1 GWAS, ALSPAC:</italic> J. Henderson, R.G. <italic>B58C:</italic> D.P.S., A.R.R. <italic>EPIC:</italic> N.J.W. <italic>FTC:</italic> J.K., L.M., T.R. <italic>KORA S3:</italic> H.E.W. <italic>Korcula:</italic> I.G., S.J., O.P., I.R., L.Z. <italic>NFBC1966:</italic> P.E., M.-R.J., A.-L.H., A.P. <italic>NSPHS:</italic> G. Zaboli. <italic>ORCADES:</italic> H.C., S.H.W., J.F.W. <italic>SHIP:</italic> S.G., B.K., H.V. <italic>TwinsUK:</italic> M.M., T.D.S. <italic>Vis:</italic> H.C., C.H., O.P., I.R., A.F.W. <italic>Stage 2a follow-up, ADONIX:</italic> A.-C.O., K.T. <italic>BHS:</italic> M.N.C., A.L.J., L.J.P. <italic>BRHS:</italic> R.W.M., S.G.W., P.H.W. <italic>BWHHS:</italic> G.D.S., S.E., D.A.L., P.H.W. <italic>Gedling:</italic> J.R.B., T.M.M., I.D.P. <italic>GS:SFHS:</italic> C.J., D.J.P. <italic>HCS:</italic> C.C., E.D., S.S. <italic>KORA F4:</italic> S.K., E.S., H.S. <italic>NFBC1986:</italic> A.-L.H., M.-R.J. <italic>Nottingham Smokers:</italic> J.D.B., I.P.H., I. Sayers, M.O. <italic>NSHD:</italic> The NSHD Respiratory Study Team. <italic>Stage 2b in silico follow-up, Health 2000:</italic> M.H., M.K.</p><p id="P6"><bold>Genotyping</bold>. <italic>Stage 1 GWAS, ALSPAC:</italic> P.D. <italic>B58C:</italic> W.L.M., WTCCC. <italic>EPIC:</italic> I.B., R.J.F.L., N.J.W., J.H.Z. <italic>FTC:</italic> J.K., I. Surakka. <italic>KORA S3:</italic> M.I., N.M.P.-H., H.G. <italic>NFBC1966:</italic> P.E., M.-R.J., L.P. <italic>ORCADES:</italic> H.C., J.F.W. <italic>SHIP:</italic> G.H. <italic>TwinsUK:</italic> N.S. <italic>Vis:</italic> C.H., I.R., A.F.W. <italic>Stage 2a follow-up, ADONIX:</italic> A.T.N., F.N. <italic>BRHS:</italic> A.D.H., R.W.M., P.H.W. <italic>GS:SFHS:</italic> A.D.M. <italic>HCS:</italic> C.C., E.D., J.W.H. <italic>KORA F4:</italic> H.G. <italic>NFBC1986:</italic> N.B.-N., J.D., P.F., M.-R.J., L.P. <italic>Nottingham Smokers:</italic> I.P.H. <italic>NSHD:</italic> D.K., A.W. <italic>STAGE 2b in silico follow-up, Health 2000:</italic> L.P., S.R., I. Surakka.</p><p id="P7"><bold>Data analysis</bold>. <italic>Stage 1 GWAS, ALSPAC:</italic> D.M.E. <italic>B58C:</italic> A.R.R. <italic>EPIC:</italic> R.J.F.L., J.H.Z. <italic>FTC:</italic> I. Surakka., L.M. <italic>KORA S3:</italic> E.A., M.I., N.M.P.-H. <italic>Korcula:</italic> C.H., J.E.H., V.V. <italic>NFBC1966:</italic> A.R. <italic>NSPHS:</italic> W.I., A.J. <italic>ORCADES:</italic> C.H., V.V. <italic>SHIP:</italic> S.G., G.H., B.K, H.V. <italic>TwinsUK:</italic> G. Zhai. <italic>Vis:</italic> C.H., V.V. <italic>Stage 2a follow-up, ADONIX:</italic> A.T.N., F.N., A.-C.O, K.T. <italic>BHS:</italic> M.N.C., J. Hui., L.J.P. <italic>BRHS:</italic> R.W.M. <italic>BWHHS:</italic> D.A.L. <italic>Gedling:</italic> M.O., M.D.T. <italic>GS:SFHS:</italic> A.K.M. <italic>HCS:</italic> J.W.H., S.S. <italic>KORA F4:</italic> E.A, H.G. <italic>NFBC1986:</italic> A.R. <italic>Nottingham Smokers</italic>: M.O., I. Sayers, M.D.T. <italic>NSHD:</italic> The NSHD Respiratory Study Team. <italic>Stage 2b in silico follow-up, Health 2000:</italic> M.K., S.R., I. Surakka.</p><p id="P8"><bold>Meta-analysis group.</bold> P.R.B., I.P.H., T.J., E.R., D.P.S., M.D.T., L.V.W.</p><p id="P9"><bold>Bioinformatics and expression profiling groups.</bold> I.P.H., M.O., I. Sayers, E.R., M.D.T., L.V.W.</p><p id="P10"><bold>Writing group.</bold> P.E., I.P.H., E.R., I. Sayers, D.P.S., M.D.T., L.V.W.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>11</day><month>2</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>13</day><month>12</month><year>2009</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>7</month><year>2010</year></pub-date><volume>42</volume><issue>1</issue><fpage>36</fpage><lpage>44</lpage><permissions><copyright-statement>© 2010 Nature America, Inc. All rights reserved.</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p id="P11">Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV<sub>1</sub>) and the ratio of FEV<sub>1</sub> to forced vital capacity (FVC) in the SpiroMeta consortium (<italic>n</italic> = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (<italic>n</italic> ≤ 32,184 additional individuals) and <italic>in silico</italic> summary association data from the CHARGE Consortium (<italic>n</italic> = 21,209) and the Health 2000 survey (<italic>n</italic> ≤ 883). We confirmed the reported locus at 4q31 and identified associations with FEV<sub>1</sub> or FEV<sub>1</sub>/FVC and common variants at five additional loci: 2q35 in <italic>TNS1</italic> (<italic>P</italic> = 1.11 × 10<sup>−12</sup>), 4q24 in <italic>GSTCD</italic> (2.18 × 10<sup>−23</sup>), 5q33 in <italic>HTR4</italic> (<italic>P</italic> = 4.29 × 10<sup>−9</sup>), 6p21 in <italic>AGER</italic> (<italic>P</italic> = 3.07 × 10<sup>−15</sup>) and 15q23 in <italic>THSD4</italic> (<italic>P</italic> = 7.24 × 10<sup>−15</sup>). mRNA analyses showed expression of <italic>TNS1, GSTCD, AGER, HTR4</italic> and <italic>THSD4</italic> in human lung tissue. These associations offer mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.</p></abstract><funding-group><award-group><funding-source country="United Kingdom">Wellcome Trust : </funding-source><award-id>075883 || WT</award-id></award-group><award-group><funding-source country="United Kingdom">Medical Research Council : </funding-source><award-id>U.1230.00.008.00005.02 || MRC_</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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