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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Heritability of Fractional Anisotropy in Human White Matter: A Comparison of Human Connectome Project and ENIGMA-DTI Data</title><author><name sortKey="Kochunov, Peter" sort="Kochunov, Peter" uniqKey="Kochunov P" first="Peter" last="Kochunov">Peter Kochunov</name></author><author><name sortKey="Jahanshad, Neda" sort="Jahanshad, Neda" uniqKey="Jahanshad N" first="Neda" last="Jahanshad">Neda Jahanshad</name></author><author><name sortKey="Marcus, Daniel" sort="Marcus, Daniel" uniqKey="Marcus D" first="Daniel" last="Marcus">Daniel Marcus</name></author><author><name sortKey="Winkler, Anderson" sort="Winkler, Anderson" uniqKey="Winkler A" first="Anderson" last="Winkler">Anderson Winkler</name></author><author><name sortKey="Sprooten, Emma" sort="Sprooten, Emma" uniqKey="Sprooten E" first="Emma" last="Sprooten">Emma Sprooten</name></author><author><name sortKey="Nichols, Thomas E" sort="Nichols, Thomas E" uniqKey="Nichols T" first="Thomas E." last="Nichols">Thomas E. Nichols</name></author><author><name sortKey="Wright, Susan N" sort="Wright, Susan N" uniqKey="Wright S" first="Susan N" last="Wright">Susan N. Wright</name></author><author><name sortKey="Hong, L Elliot" sort="Hong, L Elliot" uniqKey="Hong L" first="L Elliot" last="Hong">L Elliot Hong</name></author><author><name sortKey="Patel, Binish" sort="Patel, Binish" uniqKey="Patel B" first="Binish" last="Patel">Binish Patel</name></author><author><name sortKey="Behrens, Timothy" sort="Behrens, Timothy" uniqKey="Behrens T" first="Timothy" last="Behrens">Timothy Behrens</name></author><author><name sortKey="Jbabdi, Saad" sort="Jbabdi, Saad" uniqKey="Jbabdi S" first="Saad" last="Jbabdi">Saad Jbabdi</name></author><author><name sortKey="Andersson, Jesper" sort="Andersson, Jesper" uniqKey="Andersson J" first="Jesper" last="Andersson">Jesper Andersson</name></author><author><name sortKey="Lenglet, Christophe" sort="Lenglet, Christophe" uniqKey="Lenglet C" first="Christophe" last="Lenglet">Christophe Lenglet</name></author><author><name sortKey="Yacoub, Essa" sort="Yacoub, Essa" uniqKey="Yacoub E" first="Essa" last="Yacoub">Essa Yacoub</name></author><author><name sortKey="Moeller, Steen" sort="Moeller, Steen" uniqKey="Moeller S" first="Steen" last="Moeller">Steen Moeller</name></author><author><name sortKey="Auerbach, Eddie" sort="Auerbach, Eddie" uniqKey="Auerbach E" first="Eddie" last="Auerbach">Eddie Auerbach</name></author><author><name sortKey="Ugurbil, Kamil" sort="Ugurbil, Kamil" uniqKey="Ugurbil K" first="Kamil" last="Ugurbil">Kamil Ugurbil</name></author><author><name sortKey="Sotiropoulos, Stamatios N" sort="Sotiropoulos, Stamatios N" uniqKey="Sotiropoulos S" first="Stamatios N" last="Sotiropoulos">Stamatios N. Sotiropoulos</name></author><author><name sortKey="Brouwer, Rachel M" sort="Brouwer, Rachel M" uniqKey="Brouwer R" first="Rachel M." last="Brouwer">Rachel M. Brouwer</name></author><author><name sortKey="Landman, Bennett" sort="Landman, Bennett" uniqKey="Landman B" first="Bennett" last="Landman">Bennett Landman</name></author><author><name sortKey="Lemaitre, Herve" sort="Lemaitre, Herve" uniqKey="Lemaitre H" first="Hervé" last="Lemaitre">Hervé Lemaitre</name></author><author><name sortKey="Den Braber, Anouk" sort="Den Braber, Anouk" uniqKey="Den Braber A" first="Anouk" last="Den Braber">Anouk Den Braber</name></author><author><name sortKey="Zwiers, Marcel P" sort="Zwiers, Marcel P" uniqKey="Zwiers M" first="Marcel P." last="Zwiers">Marcel P. Zwiers</name></author><author><name sortKey="Ritchie, Stuart" sort="Ritchie, Stuart" uniqKey="Ritchie S" first="Stuart" last="Ritchie">Stuart Ritchie</name></author><author><name sortKey="Vanhulzen, Kimm" sort="Vanhulzen, Kimm" uniqKey="Vanhulzen K" first="Kimm" last="Vanhulzen">Kimm Vanhulzen</name></author><author><name sortKey="Almasy, Laura" sort="Almasy, Laura" uniqKey="Almasy L" first="Laura" last="Almasy">Laura Almasy</name></author><author><name sortKey="Curran, Joanne" sort="Curran, Joanne" uniqKey="Curran J" first="Joanne" last="Curran">Joanne Curran</name></author><author><name sortKey="Dezubicaray, Greig I" sort="Dezubicaray, Greig I" uniqKey="Dezubicaray G" first="Greig I" last="Dezubicaray">Greig I. Dezubicaray</name></author><author><name sortKey="Duggirala, Ravi" sort="Duggirala, Ravi" uniqKey="Duggirala R" first="Ravi" last="Duggirala">Ravi Duggirala</name></author><author><name sortKey="Fox, Peter" sort="Fox, Peter" uniqKey="Fox P" first="Peter" last="Fox">Peter Fox</name></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name></author><author><name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L." last="Mcmahon">Katie L. Mcmahon</name></author><author><name sortKey="Mitchell, Braxton" sort="Mitchell, Braxton" uniqKey="Mitchell B" first="Braxton" last="Mitchell">Braxton Mitchell</name></author><author><name sortKey="Olvera, Rene L" sort="Olvera, Rene L" uniqKey="Olvera R" first="Rene L" last="Olvera">Rene L. Olvera</name></author><author><name sortKey="Peterson, Charles" sort="Peterson, Charles" uniqKey="Peterson C" first="Charles" last="Peterson">Charles Peterson</name></author><author><name sortKey="Starr, John" sort="Starr, John" uniqKey="Starr J" first="John" last="Starr">John Starr</name></author><author><name sortKey="Sussmann, Jessika" sort="Sussmann, Jessika" uniqKey="Sussmann J" first="Jessika" last="Sussmann">Jessika Sussmann</name></author><author><name sortKey="Wardlaw, Joanna" sort="Wardlaw, Joanna" uniqKey="Wardlaw J" first="Joanna" last="Wardlaw">Joanna Wardlaw</name></author><author><name sortKey="Wright, Margie" sort="Wright, Margie" uniqKey="Wright M" first="Margie" last="Wright">Margie Wright</name></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name></author><author><name sortKey="Kahn, Rene" sort="Kahn, Rene" uniqKey="Kahn R" first="Rene" last="Kahn">Rene Kahn</name></author><author><name sortKey="De Geus, Eco Jc" sort="De Geus, Eco Jc" uniqKey="De Geus E" first="Eco Jc" last="De Geus">Eco Jc De Geus</name></author><author><name sortKey="Williamson, Douglas E" sort="Williamson, Douglas E" uniqKey="Williamson D" first="Douglas E" last="Williamson">Douglas E. Williamson</name></author><author><name sortKey="Hariri, Ahmad" sort="Hariri, Ahmad" uniqKey="Hariri A" first="Ahmad" last="Hariri">Ahmad Hariri</name></author><author><name sortKey="Van T Ent, Dennis" sort="Van T Ent, Dennis" uniqKey="Van T Ent D" first="Dennis" last="Van T Ent">Dennis Van T Ent</name></author><author><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E." last="Bastin">Mark E. Bastin</name></author><author><name sortKey="Mcintosh, Andrew" sort="Mcintosh, Andrew" uniqKey="Mcintosh A" first="Andrew" last="Mcintosh">Andrew Mcintosh</name></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name></author><author><name sortKey="Hulshoff Pol, Hilleke E" sort="Hulshoff Pol, Hilleke E" uniqKey="Hulshoff Pol H" first="Hilleke E." last="Hulshoff Pol">Hilleke E. Hulshoff Pol</name></author><author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name></author><author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name></author><author><name sortKey="Glahn, David C" sort="Glahn, David C" uniqKey="Glahn D" first="David C." last="Glahn">David C. Glahn</name></author><author><name sortKey="Van Essen, David C" sort="Van Essen, David C" uniqKey="Van Essen D" first="David C." last="Van Essen">David C. Van Essen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25747917</idno><idno type="pmc">4387079</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387079</idno><idno type="RBID">PMC:4387079</idno><idno type="doi">10.1016/j.neuroimage.2015.02.050</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002122</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002122</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Heritability of Fractional Anisotropy in Human White Matter: A Comparison of Human Connectome Project and ENIGMA-DTI Data</title><author><name sortKey="Kochunov, Peter" sort="Kochunov, Peter" uniqKey="Kochunov P" first="Peter" last="Kochunov">Peter Kochunov</name></author><author><name sortKey="Jahanshad, Neda" sort="Jahanshad, Neda" uniqKey="Jahanshad N" first="Neda" last="Jahanshad">Neda Jahanshad</name></author><author><name sortKey="Marcus, Daniel" sort="Marcus, Daniel" uniqKey="Marcus D" first="Daniel" last="Marcus">Daniel Marcus</name></author><author><name sortKey="Winkler, Anderson" sort="Winkler, Anderson" uniqKey="Winkler A" first="Anderson" last="Winkler">Anderson Winkler</name></author><author><name sortKey="Sprooten, Emma" sort="Sprooten, Emma" uniqKey="Sprooten E" first="Emma" last="Sprooten">Emma Sprooten</name></author><author><name sortKey="Nichols, Thomas E" sort="Nichols, Thomas E" uniqKey="Nichols T" first="Thomas E." last="Nichols">Thomas E. Nichols</name></author><author><name sortKey="Wright, Susan N" sort="Wright, Susan N" uniqKey="Wright S" first="Susan N" last="Wright">Susan N. Wright</name></author><author><name sortKey="Hong, L Elliot" sort="Hong, L Elliot" uniqKey="Hong L" first="L Elliot" last="Hong">L Elliot Hong</name></author><author><name sortKey="Patel, Binish" sort="Patel, Binish" uniqKey="Patel B" first="Binish" last="Patel">Binish Patel</name></author><author><name sortKey="Behrens, Timothy" sort="Behrens, Timothy" uniqKey="Behrens T" first="Timothy" last="Behrens">Timothy Behrens</name></author><author><name sortKey="Jbabdi, Saad" sort="Jbabdi, Saad" uniqKey="Jbabdi S" first="Saad" last="Jbabdi">Saad Jbabdi</name></author><author><name sortKey="Andersson, Jesper" sort="Andersson, Jesper" uniqKey="Andersson J" first="Jesper" last="Andersson">Jesper Andersson</name></author><author><name sortKey="Lenglet, Christophe" sort="Lenglet, Christophe" uniqKey="Lenglet C" first="Christophe" last="Lenglet">Christophe Lenglet</name></author><author><name sortKey="Yacoub, Essa" sort="Yacoub, Essa" uniqKey="Yacoub E" first="Essa" last="Yacoub">Essa Yacoub</name></author><author><name sortKey="Moeller, Steen" sort="Moeller, Steen" uniqKey="Moeller S" first="Steen" last="Moeller">Steen Moeller</name></author><author><name sortKey="Auerbach, Eddie" sort="Auerbach, Eddie" uniqKey="Auerbach E" first="Eddie" last="Auerbach">Eddie Auerbach</name></author><author><name sortKey="Ugurbil, Kamil" sort="Ugurbil, Kamil" uniqKey="Ugurbil K" first="Kamil" last="Ugurbil">Kamil Ugurbil</name></author><author><name sortKey="Sotiropoulos, Stamatios N" sort="Sotiropoulos, Stamatios N" uniqKey="Sotiropoulos S" first="Stamatios N" last="Sotiropoulos">Stamatios N. Sotiropoulos</name></author><author><name sortKey="Brouwer, Rachel M" sort="Brouwer, Rachel M" uniqKey="Brouwer R" first="Rachel M." last="Brouwer">Rachel M. Brouwer</name></author><author><name sortKey="Landman, Bennett" sort="Landman, Bennett" uniqKey="Landman B" first="Bennett" last="Landman">Bennett Landman</name></author><author><name sortKey="Lemaitre, Herve" sort="Lemaitre, Herve" uniqKey="Lemaitre H" first="Hervé" last="Lemaitre">Hervé Lemaitre</name></author><author><name sortKey="Den Braber, Anouk" sort="Den Braber, Anouk" uniqKey="Den Braber A" first="Anouk" last="Den Braber">Anouk Den Braber</name></author><author><name sortKey="Zwiers, Marcel P" sort="Zwiers, Marcel P" uniqKey="Zwiers M" first="Marcel P." last="Zwiers">Marcel P. Zwiers</name></author><author><name sortKey="Ritchie, Stuart" sort="Ritchie, Stuart" uniqKey="Ritchie S" first="Stuart" last="Ritchie">Stuart Ritchie</name></author><author><name sortKey="Vanhulzen, Kimm" sort="Vanhulzen, Kimm" uniqKey="Vanhulzen K" first="Kimm" last="Vanhulzen">Kimm Vanhulzen</name></author><author><name sortKey="Almasy, Laura" sort="Almasy, Laura" uniqKey="Almasy L" first="Laura" last="Almasy">Laura Almasy</name></author><author><name sortKey="Curran, Joanne" sort="Curran, Joanne" uniqKey="Curran J" first="Joanne" last="Curran">Joanne Curran</name></author><author><name sortKey="Dezubicaray, Greig I" sort="Dezubicaray, Greig I" uniqKey="Dezubicaray G" first="Greig I" last="Dezubicaray">Greig I. Dezubicaray</name></author><author><name sortKey="Duggirala, Ravi" sort="Duggirala, Ravi" uniqKey="Duggirala R" first="Ravi" last="Duggirala">Ravi Duggirala</name></author><author><name sortKey="Fox, Peter" sort="Fox, Peter" uniqKey="Fox P" first="Peter" last="Fox">Peter Fox</name></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name></author><author><name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L." last="Mcmahon">Katie L. Mcmahon</name></author><author><name sortKey="Mitchell, Braxton" sort="Mitchell, Braxton" uniqKey="Mitchell B" first="Braxton" last="Mitchell">Braxton Mitchell</name></author><author><name sortKey="Olvera, Rene L" sort="Olvera, Rene L" uniqKey="Olvera R" first="Rene L" last="Olvera">Rene L. Olvera</name></author><author><name sortKey="Peterson, Charles" sort="Peterson, Charles" uniqKey="Peterson C" first="Charles" last="Peterson">Charles Peterson</name></author><author><name sortKey="Starr, John" sort="Starr, John" uniqKey="Starr J" first="John" last="Starr">John Starr</name></author><author><name sortKey="Sussmann, Jessika" sort="Sussmann, Jessika" uniqKey="Sussmann J" first="Jessika" last="Sussmann">Jessika Sussmann</name></author><author><name sortKey="Wardlaw, Joanna" sort="Wardlaw, Joanna" uniqKey="Wardlaw J" first="Joanna" last="Wardlaw">Joanna Wardlaw</name></author><author><name sortKey="Wright, Margie" sort="Wright, Margie" uniqKey="Wright M" first="Margie" last="Wright">Margie Wright</name></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name></author><author><name sortKey="Kahn, Rene" sort="Kahn, Rene" uniqKey="Kahn R" first="Rene" last="Kahn">Rene Kahn</name></author><author><name sortKey="De Geus, Eco Jc" sort="De Geus, Eco Jc" uniqKey="De Geus E" first="Eco Jc" last="De Geus">Eco Jc De Geus</name></author><author><name sortKey="Williamson, Douglas E" sort="Williamson, Douglas E" uniqKey="Williamson D" first="Douglas E" last="Williamson">Douglas E. Williamson</name></author><author><name sortKey="Hariri, Ahmad" sort="Hariri, Ahmad" uniqKey="Hariri A" first="Ahmad" last="Hariri">Ahmad Hariri</name></author><author><name sortKey="Van T Ent, Dennis" sort="Van T Ent, Dennis" uniqKey="Van T Ent D" first="Dennis" last="Van T Ent">Dennis Van T Ent</name></author><author><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E." last="Bastin">Mark E. Bastin</name></author><author><name sortKey="Mcintosh, Andrew" sort="Mcintosh, Andrew" uniqKey="Mcintosh A" first="Andrew" last="Mcintosh">Andrew Mcintosh</name></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name></author><author><name sortKey="Hulshoff Pol, Hilleke E" sort="Hulshoff Pol, Hilleke E" uniqKey="Hulshoff Pol H" first="Hilleke E." last="Hulshoff Pol">Hilleke E. Hulshoff Pol</name></author><author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name></author><author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name></author><author><name sortKey="Glahn, David C" sort="Glahn, David C" uniqKey="Glahn D" first="David C." last="Glahn">David C. Glahn</name></author><author><name sortKey="Van Essen, David C" sort="Van Essen, David C" uniqKey="Van Essen D" first="David C." last="Van Essen">David C. Van Essen</name></author></analytic><series><title level="j">NeuroImage</title><idno type="ISSN">1053-8119</idno><idno type="eISSN">1095-9572</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">The degree to which genetic factors influence brain connectivity is beginning to be understood. Large-scale efforts are underway to map the profile of genetic effects in various brain regions. The NIH-funded Human Connectome Project (HCP) is providing data valuable for analyzing the degree of genetic influence underlying brain connectivity revealed by state-of-the-art neuroimaging methods. We calculated the heritability of the fractional anisotropy (FA) measure derived from diffusion tensor imaging (DTI) reconstruction in 481 HCP subjects (194/287 M/F) consisting of 57/60 pairs of mono- and dizygotic twins, and 246 siblings. FA measurements were derived using (Enhancing NeuroImaging Genetics through Meta-Analysis) ENIGMA DTI protocols and heritability estimates were calculated using the SOLAR-Eclipse imaging genetic analysis package. We compared heritability estimates derived from HCP data to those publicly available through the ENIGMA-DTI consortium, which were pooled together from five-family based studies across the US, Europe, and Australia. FA measurements from the HCP cohort for eleven major white matter tracts were highly heritable (h<sup>2</sup>=0.53–0.90, p<10<sup>−5</sup>), and were significantly correlated with the joint-analytical estimates from the ENIGMA cohort on the tract and voxel-wise levels. The similarity in regional heritability suggests that the additive genetic contribution to white matter microstructure is consistent across populations and imaging acquisition parameters. It also suggests the overarching genetic influence provides an opportunity to define a common genetic search space for future gene-discovery studies. Uniquely, the measurements of additive genetic contribution performed in this study can be repeated using online genetic analysis tools provided by the HCP ConnectomeDB web application.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9215515</journal-id><journal-id journal-id-type="pubmed-jr-id">20498</journal-id><journal-id journal-id-type="nlm-ta">Neuroimage</journal-id><journal-id journal-id-type="iso-abbrev">Neuroimage</journal-id><journal-title-group><journal-title>NeuroImage</journal-title></journal-title-group><issn pub-type="ppub">1053-8119</issn><issn pub-type="epub">1095-9572</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25747917</article-id><article-id pub-id-type="pmc">4387079</article-id><article-id pub-id-type="doi">10.1016/j.neuroimage.2015.02.050</article-id><article-id pub-id-type="manuscript">NIHMS669356</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Heritability of Fractional Anisotropy in Human White Matter: A Comparison of Human Connectome Project and ENIGMA-DTI Data</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kochunov</surname><given-names>Peter</given-names></name><xref rid="FN2" ref-type="author-notes">#</xref><aff id="A1">Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, USA</aff></contrib><contrib contrib-type="author"><name><surname>Jahanshad</surname><given-names>Neda</given-names></name><xref rid="FN2" ref-type="author-notes">#</xref><aff id="A2">Imaging Genetics Center, Institute for Neuroimaging and Informatics, Department of Neurology Keck School of Medicine University of Southern California, Marina del Rey, USA</aff></contrib><contrib contrib-type="author"><name><surname>Marcus</surname><given-names>Daniel</given-names></name><aff id="A3">Department of Radiology, Washington University School of Medicine, St. Louis, USA</aff></contrib><contrib contrib-type="author"><name><surname>Winkler</surname><given-names>Anderson</given-names></name><aff id="A4">FMRIB Centre, Oxford University, Oxford, UK</aff></contrib><contrib contrib-type="author"><name><surname>Sprooten</surname><given-names>Emma</given-names></name><aff id="A5">Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, USA</aff></contrib><contrib contrib-type="author"><name><surname>Nichols</surname><given-names>Thomas E.</given-names></name><aff id="A6">Department of Statistics, University of Warwick, Warwick, UK</aff></contrib><contrib contrib-type="author"><name><surname>Wright</surname><given-names>Susan N</given-names></name><aff id="A7">Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, USA</aff></contrib><contrib contrib-type="author"><name><surname>Hong</surname><given-names>L Elliot</given-names></name><aff id="A8">Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, USA</aff></contrib><contrib contrib-type="author"><name><surname>Patel</surname><given-names>Binish</given-names></name><aff id="A9">Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, USA</aff></contrib><contrib contrib-type="author"><name><surname>Behrens</surname><given-names>Timothy</given-names></name><aff id="A10">FMRIB Centre, Oxford University, Oxford, UK</aff></contrib><contrib contrib-type="author"><name><surname>Jbabdi</surname><given-names>Saad</given-names></name><aff id="A11">FMRIB Centre, Oxford University, Oxford, UK</aff></contrib><contrib contrib-type="author"><name><surname>Andersson</surname><given-names>Jesper</given-names></name><aff id="A12">FMRIB Centre, Oxford University, Oxford, UK</aff></contrib><contrib contrib-type="author"><name><surname>Lenglet</surname><given-names>Christophe</given-names></name><aff id="A13">Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, USA</aff></contrib><contrib contrib-type="author"><name><surname>Yacoub</surname><given-names>Essa</given-names></name><aff id="A14">Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, USA</aff></contrib><contrib contrib-type="author"><name><surname>Moeller</surname><given-names>Steen</given-names></name><aff id="A15">Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, USA</aff></contrib><contrib contrib-type="author"><name><surname>Auerbach</surname><given-names>Eddie</given-names></name><aff id="A16">Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, USA</aff></contrib><contrib contrib-type="author"><name><surname>Ugurbil</surname><given-names>Kamil</given-names></name><aff id="A17">Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, USA</aff></contrib><contrib contrib-type="author"><name><surname>Sotiropoulos</surname><given-names>Stamatios N</given-names></name><aff id="A18">FMRIB Centre, Oxford University, Oxford, UK</aff></contrib><contrib contrib-type="author"><name><surname>Brouwer</surname><given-names>Rachel M.</given-names></name><aff id="A19">University Medical Center Utrecht, Utrecht, The Netherlands</aff></contrib><contrib contrib-type="author"><name><surname>Landman</surname><given-names>Bennett</given-names></name><aff id="A20">Vanderbilt University, Nashville, TN</aff></contrib><contrib contrib-type="author"><name><surname>Lemaitre</surname><given-names>Hervé</given-names></name><aff id="A21">INSERM-CEA-Faculté de Médecine Paris-Sud, Orsay, France</aff></contrib><contrib contrib-type="author"><name><surname>den Braber</surname><given-names>Anouk</given-names></name><aff id="A22">VU University, Amsterdam, The Netherlands</aff></contrib><contrib contrib-type="author"><name><surname>Zwiers</surname><given-names>Marcel P.</given-names></name><aff id="A23">Radboud University, Nijmegen, The Netherlands</aff></contrib><contrib contrib-type="author"><name><surname>Ritchie</surname><given-names>Stuart</given-names></name><aff id="A24">University of Edinburgh, Edinburgh, UK</aff></contrib><contrib contrib-type="author"><name><surname>vanHulzen</surname><given-names>Kimm</given-names></name><aff id="A25">Radboud University, Nijmegen, The Netherlands</aff></contrib><contrib contrib-type="author"><name><surname>Almasy</surname><given-names>Laura</given-names></name><aff id="A26">Texas Biomedical Research Institute, San Antonio, TX</aff></contrib><contrib contrib-type="author"><name><surname>Curran</surname><given-names>Joanne</given-names></name><aff id="A27">Texas Biomedical Research Institute, San Antonio, TX</aff></contrib><contrib contrib-type="author"><name><surname>deZubicaray</surname><given-names>Greig I</given-names></name><aff id="A28">University of Queensland, Brisbane, Australia</aff></contrib><contrib contrib-type="author"><name><surname>Duggirala</surname><given-names>Ravi</given-names></name><aff id="A29">Texas Biomedical Research Institute, San Antonio, TX</aff></contrib><contrib contrib-type="author"><name><surname>Fox</surname><given-names>Peter</given-names></name><aff id="A30">University of Texas Health Science Center San Antonio, San Antonio, TX</aff></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Nicholas G.</given-names></name><aff id="A31">QIMR Berghofer, Brisbane, Australia</aff></contrib><contrib contrib-type="author"><name><surname>McMahon</surname><given-names>Katie L.</given-names></name><aff id="A32">University of Queensland, Brisbane, Australia</aff></contrib><contrib contrib-type="author"><name><surname>Mitchell</surname><given-names>Braxton</given-names></name><aff id="A33">University of Maryland, Baltimore, MD USA</aff></contrib><contrib contrib-type="author"><name><surname>Olvera</surname><given-names>Rene L</given-names></name><aff id="A34">University of Texas Health Science Center San Antonio, San Antonio, TX</aff></contrib><contrib contrib-type="author"><name><surname>Peterson</surname><given-names>Charles</given-names></name><aff id="A35">Texas Biomedical Research Institute, San Antonio, TX</aff></contrib><contrib contrib-type="author"><name><surname>Starr</surname><given-names>John</given-names></name><aff id="A36">University of Edinburgh, Edinburgh, UK</aff></contrib><contrib contrib-type="author"><name><surname>Sussmann</surname><given-names>Jessika</given-names></name><aff id="A37">University of Edinburgh, Edinburgh, UK</aff></contrib><contrib contrib-type="author"><name><surname>Wardlaw</surname><given-names>Joanna</given-names></name><aff id="A38">University of Edinburgh, Edinburgh, UK</aff></contrib><contrib contrib-type="author"><name><surname>Wright</surname><given-names>Margie</given-names></name><aff id="A39">QIMR Berghofer, Brisbane, Australia</aff></contrib><contrib contrib-type="author"><name><surname>Boomsma</surname><given-names>Dorret I.</given-names></name><aff id="A40">VU University, Amsterdam, The Netherlands</aff></contrib><contrib contrib-type="author"><name><surname>Kahn</surname><given-names>Rene</given-names></name><aff id="A41">University Medical Center Utrecht, Utrecht, The Netherlands</aff></contrib><contrib contrib-type="author"><name><surname>de Geus</surname><given-names>Eco JC</given-names></name><aff id="A42">VU University, Amsterdam, The Netherlands</aff></contrib><contrib contrib-type="author"><name><surname>Williamson</surname><given-names>Douglas E</given-names></name><aff id="A43">University of Texas Health Science Center San Antonio, San Antonio, TX</aff></contrib><contrib contrib-type="author"><name><surname>Hariri</surname><given-names>Ahmad</given-names></name><aff id="A44">Duke University, Durahm, NC</aff></contrib><contrib contrib-type="author"><name><surname>van t Ent</surname><given-names>Dennis</given-names></name><aff id="A45">VU University, Amsterdam, The Netherlands</aff></contrib><contrib contrib-type="author"><name><surname>Bastin</surname><given-names>Mark E.</given-names></name><aff id="A46">University of Edinburgh, Edinburgh, UK</aff></contrib><contrib contrib-type="author"><name><surname>McIntosh</surname><given-names>Andrew</given-names></name><aff id="A47">University of Edinburgh, Edinburgh, UK</aff></contrib><contrib contrib-type="author"><name><surname>Deary</surname><given-names>Ian J.</given-names></name><aff id="A48">University of Edinburgh, Edinburgh, UK</aff></contrib><contrib contrib-type="author"><name><surname>Hulshoff pol</surname><given-names>Hilleke E.</given-names></name><aff id="A49">University Medical Center Utrecht, Utrecht, The Netherlands</aff></contrib><contrib contrib-type="author"><name><surname>Blangero</surname><given-names>John</given-names></name><aff id="A50">Texas Biomedical Research Institute, San Antonio, TX</aff></contrib><contrib contrib-type="author"><name><surname>Thompson</surname><given-names>Paul M.</given-names></name><aff id="A51">Imaging Genetics Center, Institute for Neuroimaging and Informatics, Department of Neurology Keck School of Medicine University of Southern California, Marina del Rey, USA</aff></contrib><contrib contrib-type="author"><name><surname>Glahn</surname><given-names>David C.</given-names></name><xref rid="FN1" ref-type="author-notes">*</xref><aff id="A52">Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, USA</aff></contrib><contrib contrib-type="author"><name><surname>Van Essen</surname><given-names>David C.</given-names></name><xref rid="FN1" ref-type="author-notes">*</xref><aff id="A53">Anatomy & Neurobiology Department at Washington University in St. Louis, St. Louis, USA</aff></contrib></contrib-group><author-notes><corresp id="FN1"><label>*</label>Please address correspondence to: Dr. Peter Kochunov, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, School of Medicine, Baltimore, MD, USA, Phone: (410) 402-6110, Fax : (410)-402-7198, <email>pkochunov@mprc.umaryland.edu</email></corresp><fn id="FN2"><label>#</label><p>Peter Kochunov and Neda Jahanshad share first authorship on this manuscript</p></fn><fn id="FN3"><p>David C. Glahn and David C. Van Essen share last authorship</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>18</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>04</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>5</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2016</year></pub-date><volume>111</volume><fpage>300</fpage><lpage>311</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.neuroimage.2015.02.050</pmc-comment>
<abstract><p id="P2">The degree to which genetic factors influence brain connectivity is beginning to be understood. Large-scale efforts are underway to map the profile of genetic effects in various brain regions. The NIH-funded Human Connectome Project (HCP) is providing data valuable for analyzing the degree of genetic influence underlying brain connectivity revealed by state-of-the-art neuroimaging methods. We calculated the heritability of the fractional anisotropy (FA) measure derived from diffusion tensor imaging (DTI) reconstruction in 481 HCP subjects (194/287 M/F) consisting of 57/60 pairs of mono- and dizygotic twins, and 246 siblings. FA measurements were derived using (Enhancing NeuroImaging Genetics through Meta-Analysis) ENIGMA DTI protocols and heritability estimates were calculated using the SOLAR-Eclipse imaging genetic analysis package. We compared heritability estimates derived from HCP data to those publicly available through the ENIGMA-DTI consortium, which were pooled together from five-family based studies across the US, Europe, and Australia. FA measurements from the HCP cohort for eleven major white matter tracts were highly heritable (h<sup>2</sup>=0.53–0.90, p<10<sup>−5</sup>), and were significantly correlated with the joint-analytical estimates from the ENIGMA cohort on the tract and voxel-wise levels. The similarity in regional heritability suggests that the additive genetic contribution to white matter microstructure is consistent across populations and imaging acquisition parameters. It also suggests the overarching genetic influence provides an opportunity to define a common genetic search space for future gene-discovery studies. Uniquely, the measurements of additive genetic contribution performed in this study can be repeated using online genetic analysis tools provided by the HCP ConnectomeDB web application.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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