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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, <italic>Manduca sexta</italic></title><author><name sortKey="Kanost, Michael R" sort="Kanost, Michael R" uniqKey="Kanost M" first="Michael R." last="Kanost">Michael R. Kanost</name><affiliation><nlm:aff id="A1">Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Arrese, Estela L" sort="Arrese, Estela L" uniqKey="Arrese E" first="Estela L." last="Arrese">Estela L. Arrese</name><affiliation><nlm:aff id="A2">Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Cao, Xiaolong" sort="Cao, Xiaolong" uniqKey="Cao X" first="Xiaolong" last="Cao">Xiaolong Cao</name><affiliation><nlm:aff id="A3">Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Yun Ru" sort="Chen, Yun Ru" uniqKey="Chen Y" first="Yun-Ru" last="Chen">Yun-Ru Chen</name><affiliation><nlm:aff id="A4">Boyce Thompson Institute at Cornell University, Tower Road Ithaca, NY, 14853, USA</nlm:aff></affiliation></author><author><name sortKey="Chellapilla, Sanjay" sort="Chellapilla, Sanjay" uniqKey="Chellapilla S" first="Sanjay" last="Chellapilla">Sanjay Chellapilla</name><affiliation><nlm:aff id="A5">KSU Bioinformatics Center, Division of Biology, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Goldsmith, Marian R" sort="Goldsmith, Marian R" uniqKey="Goldsmith M" first="Marian R" last="Goldsmith">Marian R. Goldsmith</name><affiliation><nlm:aff id="A6">Biological Sciences Department, University of Rhode Island, Kingston, RI, 02881, USA</nlm:aff></affiliation></author><author><name sortKey="Grosse Wilde, Ewald" sort="Grosse Wilde, Ewald" uniqKey="Grosse Wilde E" first="Ewald" last="Grosse-Wilde">Ewald Grosse-Wilde</name><affiliation><nlm:aff id="A7">Max Planck Institute for Chemical Ecology, Department of Evolutionary Neuroethology, Hans-Knoell-Strasse, 8, D-07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Heckel, David G" sort="Heckel, David G" uniqKey="Heckel D" first="David G." last="Heckel">David G. Heckel</name><affiliation><nlm:aff id="A8">Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Herndon, Nicolae" sort="Herndon, Nicolae" uniqKey="Herndon N" first="Nicolae" last="Herndon">Nicolae Herndon</name><affiliation><nlm:aff id="A5">KSU Bioinformatics Center, Division of Biology, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Jiang, Haobo" sort="Jiang, Haobo" uniqKey="Jiang H" first="Haobo" last="Jiang">Haobo Jiang</name><affiliation><nlm:aff id="A3">Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Papanicolaou, Alexie" sort="Papanicolaou, Alexie" uniqKey="Papanicolaou A" first="Alexie" last="Papanicolaou">Alexie Papanicolaou</name><affiliation><nlm:aff id="A9">Hawkesbury Institute for the Environment, Western Sydney University, Richmond, NSW, 2753, Australia</nlm:aff></affiliation></author><author><name sortKey="Qu, Jiaxin" sort="Qu, Jiaxin" uniqKey="Qu J" first="Jiaxin" last="Qu">Jiaxin Qu</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Soulages, Jose L" sort="Soulages, Jose L" uniqKey="Soulages J" first="Jose L." last="Soulages">Jose L. Soulages</name><affiliation><nlm:aff id="A2">Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Vogel, Heiko" sort="Vogel, Heiko" uniqKey="Vogel H" first="Heiko" last="Vogel">Heiko Vogel</name><affiliation><nlm:aff id="A8">Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Walters, James" sort="Walters, James" uniqKey="Walters J" first="James" last="Walters">James Walters</name><affiliation><nlm:aff id="A11">Department of Ecology and Evolutionary Biology, Univ. Kansas, Lawrence, KS, 66045, USA</nlm:aff></affiliation></author><author><name sortKey="Waterhouse, Robert M" sort="Waterhouse, Robert M" uniqKey="Waterhouse R" first="Robert M." last="Waterhouse">Robert M. Waterhouse</name><affiliation><nlm:aff id="A12">Department of Genetic Medicine and Development, University of Geneva Medical School, rue Michel-Servet 1, 1211, Geneva, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Swiss Institute of Bioinformatics, rue Michel-Servet 1, 1211, Geneva, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA, 02139, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A15">The Broad Institute of MIT and Harvard, Cambridge, 415 Main Street, MA, 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Ahn, Seung Joon" sort="Ahn, Seung Joon" uniqKey="Ahn S" first="Seung-Joon" last="Ahn">Seung-Joon Ahn</name><affiliation><nlm:aff id="A8">Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Almeida, Francisca C" sort="Almeida, Francisca C" uniqKey="Almeida F" first="Francisca C." last="Almeida">Francisca C. Almeida</name><affiliation><nlm:aff id="A16">Department de Genètica and Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="An, Chunju" sort="An, Chunju" uniqKey="An C" first="Chunju" last="An">Chunju An</name><affiliation><nlm:aff id="A17">Department of Entomology, China Agricultural University, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Aqrawi, Peshtewani" sort="Aqrawi, Peshtewani" uniqKey="Aqrawi P" first="Peshtewani" last="Aqrawi">Peshtewani Aqrawi</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Bretschneider, Anne" sort="Bretschneider, Anne" uniqKey="Bretschneider A" first="Anne" last="Bretschneider">Anne Bretschneider</name><affiliation><nlm:aff id="A8">Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Bryant, William B" sort="Bryant, William B" uniqKey="Bryant W" first="William B." last="Bryant">William B. Bryant</name><affiliation><nlm:aff id="A18">Division of Biology, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Bucks, Sascha" sort="Bucks, Sascha" uniqKey="Bucks S" first="Sascha" last="Bucks">Sascha Bucks</name><affiliation><nlm:aff id="A7">Max Planck Institute for Chemical Ecology, Department of Evolutionary Neuroethology, Hans-Knoell-Strasse, 8, D-07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Chao, Hsu" sort="Chao, Hsu" uniqKey="Chao H" first="Hsu" last="Chao">Hsu Chao</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Chevignon, Germain" sort="Chevignon, Germain" uniqKey="Chevignon G" first="Germain" last="Chevignon">Germain Chevignon</name><affiliation><nlm:aff id="A19">Institut de Recherche sur la Biologie de l’Insecte, UMR CNRS 7261, UFR Sciences et Techniques, Université François-Rabelais, Tours, France</nlm:aff></affiliation></author><author><name sortKey="Christen, Jayne M" sort="Christen, Jayne M" uniqKey="Christen J" first="Jayne M." last="Christen">Jayne M. Christen</name><affiliation><nlm:aff id="A1">Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Clarke, David F" sort="Clarke, David F" uniqKey="Clarke D" first="David F." last="Clarke">David F. Clarke</name><affiliation><nlm:aff id="A20">CSIRO Land and Water, Clunies Ross St, Acton, ACT, 2601, Australia</nlm:aff></affiliation></author><author><name sortKey="Dittmer, Neal T" sort="Dittmer, Neal T" uniqKey="Dittmer N" first="Neal T." last="Dittmer">Neal T. Dittmer</name><affiliation><nlm:aff id="A1">Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Ferguson, Laura C F" sort="Ferguson, Laura C F" uniqKey="Ferguson L" first="Laura C. F." last="Ferguson">Laura C. F. Ferguson</name><affiliation><nlm:aff id="A21">Department of Zoology, South Parks Road, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Garavelou, Spyridoula" sort="Garavelou, Spyridoula" uniqKey="Garavelou S" first="Spyridoula" last="Garavelou">Spyridoula Garavelou</name><affiliation><nlm:aff id="A22">Centre of Systems Biology, Biomedical Research Foundation, Academy of Athens, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Gordon, Karl H J" sort="Gordon, Karl H J" uniqKey="Gordon K" first="Karl H. J." last="Gordon">Karl H. J. Gordon</name><affiliation><nlm:aff id="A23">CSIRO Health and Biosecurity, Clunies Ross St, Acton, ACT, 2601, Australia</nlm:aff></affiliation></author><author><name sortKey="Gunaratna, Ramesh T" sort="Gunaratna, Ramesh T" uniqKey="Gunaratna R" first="Ramesh T." last="Gunaratna">Ramesh T. Gunaratna</name><affiliation><nlm:aff id="A3">Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Han, Yi" sort="Han, Yi" uniqKey="Han Y" first="Yi" last="Han">Yi Han</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Hauser, Frank" sort="Hauser, Frank" uniqKey="Hauser F" first="Frank" last="Hauser">Frank Hauser</name><affiliation><nlm:aff id="A24">Center for Functional and Comparative Insect Genomics, Department of Biology, University of Copenhagen, Universitetsparken 15, DK-21oo, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="He, Yan" sort="He, Yan" uniqKey="He Y" first="Yan" last="He">Yan He</name><affiliation><nlm:aff id="A3">Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Heidel Fischer, Hanna" sort="Heidel Fischer, Hanna" uniqKey="Heidel Fischer H" first="Hanna" last="Heidel-Fischer">Hanna Heidel-Fischer</name><affiliation><nlm:aff id="A8">Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Hirsh, Ariana" sort="Hirsh, Ariana" uniqKey="Hirsh A" first="Ariana" last="Hirsh">Ariana Hirsh</name><affiliation><nlm:aff id="A25">Department of Biology, Barnard College, Columbia University, 3009 Broadway, New York, NY, 10027, USA</nlm:aff></affiliation></author><author><name sortKey="Hu, Yingxia" sort="Hu, Yingxia" uniqKey="Hu Y" first="Yingxia" last="Hu">Yingxia Hu</name><affiliation><nlm:aff id="A3">Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Jiang, Hongbo" sort="Jiang, Hongbo" uniqKey="Jiang H" first="Hongbo" last="Jiang">Hongbo Jiang</name><affiliation><nlm:aff id="A26">Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing, 400715, China</nlm:aff></affiliation></author><author><name sortKey="Kalra, Divya" sort="Kalra, Divya" uniqKey="Kalra D" first="Divya" last="Kalra">Divya Kalra</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Klinner, Christian" sort="Klinner, Christian" uniqKey="Klinner C" first="Christian" last="Klinner">Christian Klinner</name><affiliation><nlm:aff id="A7">Max Planck Institute for Chemical Ecology, Department of Evolutionary Neuroethology, Hans-Knoell-Strasse, 8, D-07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Konig, Christopher" sort="Konig, Christopher" uniqKey="Konig C" first="Christopher" last="König">Christopher König</name><affiliation><nlm:aff id="A7">Max Planck Institute for Chemical Ecology, Department of Evolutionary Neuroethology, Hans-Knoell-Strasse, 8, D-07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Kovar, Christie" sort="Kovar, Christie" uniqKey="Kovar C" first="Christie" last="Kovar">Christie Kovar</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Kroll, Ashley R" sort="Kroll, Ashley R" uniqKey="Kroll A" first="Ashley R." last="Kroll">Ashley R. Kroll</name><affiliation><nlm:aff id="A27">Department of Biology, Reed College, Portland, OR, 97202, USA</nlm:aff></affiliation></author><author><name sortKey="Kuwar, Suyog S" sort="Kuwar, Suyog S" uniqKey="Kuwar S" first="Suyog S." last="Kuwar">Suyog S. Kuwar</name><affiliation><nlm:aff id="A8">Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Lee, Sandy L" sort="Lee, Sandy L" uniqKey="Lee S" first="Sandy L." last="Lee">Sandy L. Lee</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Lehman, Rudiger" sort="Lehman, Rudiger" uniqKey="Lehman R" first="Rüdiger" last="Lehman">Rüdiger Lehman</name><affiliation><nlm:aff id="A28">Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Bioresources Project Group, Winchesterstrasse 2, 35394, Gießen, Germany</nlm:aff></affiliation></author><author><name sortKey="Li, Kai" sort="Li, Kai" uniqKey="Li K" first="Kai" last="Li">Kai Li</name><affiliation><nlm:aff id="A29">College of Chemistry, Chemical Engineering, and Biotechnology, Donghua University, Shanghai, 201620, China</nlm:aff></affiliation></author><author><name sortKey="Li, Zhaofei" sort="Li, Zhaofei" uniqKey="Li Z" first="Zhaofei" last="Li">Zhaofei Li</name><affiliation><nlm:aff id="A30">College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, China</nlm:aff></affiliation></author><author><name sortKey="Liang, Hanquan" sort="Liang, Hanquan" uniqKey="Liang H" first="Hanquan" last="Liang">Hanquan Liang</name><affiliation><nlm:aff id="A31">McDermott Center for Human Growth and Development, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA</nlm:aff></affiliation></author><author><name sortKey="Lovelace, Shanna" sort="Lovelace, Shanna" uniqKey="Lovelace S" first="Shanna" last="Lovelace">Shanna Lovelace</name><affiliation><nlm:aff id="A32">Department of Biological Sciences, University of Southern Maine, Portland, ME, 04104, USA</nlm:aff></affiliation></author><author><name sortKey="Lu, Zhiqiang" sort="Lu, Zhiqiang" uniqKey="Lu Z" first="Zhiqiang" last="Lu">Zhiqiang Lu</name><affiliation><nlm:aff id="A30">College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, China</nlm:aff></affiliation></author><author><name sortKey="Mansfield, Jennifer H" sort="Mansfield, Jennifer H" uniqKey="Mansfield J" first="Jennifer H." last="Mansfield">Jennifer H. Mansfield</name><affiliation><nlm:aff id="A25">Department of Biology, Barnard College, Columbia University, 3009 Broadway, New York, NY, 10027, USA</nlm:aff></affiliation></author><author><name sortKey="Mcculloch, Kyle J" sort="Mcculloch, Kyle J" uniqKey="Mcculloch K" first="Kyle J." last="Mcculloch">Kyle J. Mcculloch</name><affiliation><nlm:aff id="A33">Department of Ecology and Evolutionary Biology, University of California, Irvine, CA, 92697, USA</nlm:aff></affiliation></author><author><name sortKey="Mathew, Tittu" sort="Mathew, Tittu" uniqKey="Mathew T" first="Tittu" last="Mathew">Tittu Mathew</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Morton, Brian" sort="Morton, Brian" uniqKey="Morton B" first="Brian" last="Morton">Brian Morton</name><affiliation><nlm:aff id="A25">Department of Biology, Barnard College, Columbia University, 3009 Broadway, New York, NY, 10027, USA</nlm:aff></affiliation></author><author><name sortKey="Muzny, Donna M" sort="Muzny, Donna M" uniqKey="Muzny D" first="Donna M." last="Muzny">Donna M. Muzny</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Neunemann, David" sort="Neunemann, David" uniqKey="Neunemann D" first="David" last="Neunemann">David Neunemann</name><affiliation><nlm:aff id="A8">Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Ongeri, Fiona" sort="Ongeri, Fiona" uniqKey="Ongeri F" first="Fiona" last="Ongeri">Fiona Ongeri</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Pauchet, Yannick" sort="Pauchet, Yannick" uniqKey="Pauchet Y" first="Yannick" last="Pauchet">Yannick Pauchet</name><affiliation><nlm:aff id="A8">Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Pu, Ling Ling" sort="Pu, Ling Ling" uniqKey="Pu L" first="Ling-Ling" last="Pu">Ling-Ling Pu</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Pyrousis, Ioannis" sort="Pyrousis, Ioannis" uniqKey="Pyrousis I" first="Ioannis" last="Pyrousis">Ioannis Pyrousis</name><affiliation><nlm:aff id="A22">Centre of Systems Biology, Biomedical Research Foundation, Academy of Athens, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Rao, Xiang Jun" sort="Rao, Xiang Jun" uniqKey="Rao X" first="Xiang-Jun" last="Rao">Xiang-Jun Rao</name><affiliation><nlm:aff id="A34">School of Plant Protection, Anhui Agricultural University, Hefei, Anhui, China</nlm:aff></affiliation></author><author><name sortKey="Redding, Amanda" sort="Redding, Amanda" uniqKey="Redding A" first="Amanda" last="Redding">Amanda Redding</name><affiliation><nlm:aff id="A35">Department of Biology, University of Rochester, Rochester, NY, 14627, USA</nlm:aff></affiliation></author><author><name sortKey="Roesel, Charles" sort="Roesel, Charles" uniqKey="Roesel C" first="Charles" last="Roesel">Charles Roesel</name><affiliation><nlm:aff id="A36">Department of Marine and Environmental Sciences, Northeastern University, Boston, MA, 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Sanchez Gracia, Alejandro" sort="Sanchez Gracia, Alejandro" uniqKey="Sanchez Gracia A" first="Alejandro" last="Sanchez-Gracia">Alejandro Sanchez-Gracia</name><affiliation><nlm:aff id="A16">Department de Genètica and Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Schaack, Sarah" sort="Schaack, Sarah" uniqKey="Schaack S" first="Sarah" last="Schaack">Sarah Schaack</name><affiliation><nlm:aff id="A27">Department of Biology, Reed College, Portland, OR, 97202, USA</nlm:aff></affiliation></author><author><name sortKey="Shukla, Aditi" sort="Shukla, Aditi" uniqKey="Shukla A" first="Aditi" last="Shukla">Aditi Shukla</name><affiliation><nlm:aff id="A25">Department of Biology, Barnard College, Columbia University, 3009 Broadway, New York, NY, 10027, USA</nlm:aff></affiliation></author><author><name sortKey="Tetreau, Guillaume" sort="Tetreau, Guillaume" uniqKey="Tetreau G" first="Guillaume" last="Tetreau">Guillaume Tetreau</name><affiliation><nlm:aff id="A37">Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY, 14456, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Yang" sort="Wang, Yang" uniqKey="Wang Y" first="Yang" last="Wang">Yang Wang</name><affiliation><nlm:aff id="A3">Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Xiong, Guang Hua" sort="Xiong, Guang Hua" uniqKey="Xiong G" first="Guang-Hua" last="Xiong">Guang-Hua Xiong</name><affiliation><nlm:aff id="A38">State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Traut, Walther" sort="Traut, Walther" uniqKey="Traut W" first="Walther" last="Traut">Walther Traut</name><affiliation><nlm:aff id="A39">Institut fuer Biologie, Universitaet Luebeck, D-23538, Luebeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Walsh, Tom K" sort="Walsh, Tom K" uniqKey="Walsh T" first="Tom K." last="Walsh">Tom K. Walsh</name><affiliation><nlm:aff id="A20">CSIRO Land and Water, Clunies Ross St, Acton, ACT, 2601, Australia</nlm:aff></affiliation></author><author><name sortKey="Worley, Kim C" sort="Worley, Kim C" uniqKey="Worley K" first="Kim C." last="Worley">Kim C. Worley</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Wu, Di" sort="Wu, Di" uniqKey="Wu D" first="Di" last="Wu">Di Wu</name><affiliation><nlm:aff id="A1">Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Wu, Wenbi" sort="Wu, Wenbi" uniqKey="Wu W" first="Wenbi" last="Wu">Wenbi Wu</name><affiliation><nlm:aff id="A18">Division of Biology, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Wu, Yuan Qing" sort="Wu, Yuan Qing" uniqKey="Wu Y" first="Yuan-Qing" last="Wu">Yuan-Qing Wu</name></author><author><name sortKey="Zhang, Xiufeng" sort="Zhang, Xiufeng" uniqKey="Zhang X" first="Xiufeng" last="Zhang">Xiufeng Zhang</name><affiliation><nlm:aff id="A3">Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Zou, Zhen" sort="Zou, Zhen" uniqKey="Zou Z" first="Zhen" last="Zou">Zhen Zou</name><affiliation><nlm:aff id="A38">State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Zucker, Hannah" sort="Zucker, Hannah" uniqKey="Zucker H" first="Hannah" last="Zucker">Hannah Zucker</name><affiliation><nlm:aff id="A40">Neuroscience Program, Hamilton College, Clinton, NY, 13323, USA</nlm:aff></affiliation></author><author><name sortKey="Briscoe, Adriana D" sort="Briscoe, Adriana D" uniqKey="Briscoe A" first="Adriana D." last="Briscoe">Adriana D. Briscoe</name><affiliation><nlm:aff id="A33">Department of Ecology and Evolutionary Biology, University of California, Irvine, CA, 92697, USA</nlm:aff></affiliation></author><author><name sortKey="Burmester, Thorsten" sort="Burmester, Thorsten" uniqKey="Burmester T" first="Thorsten" last="Burmester">Thorsten Burmester</name><affiliation><nlm:aff id="A41">Institute of Zoology, University of Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Clem, Rollie J" sort="Clem, Rollie J" uniqKey="Clem R" first="Rollie J." last="Clem">Rollie J. Clem</name><affiliation><nlm:aff id="A18">Division of Biology, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Feyereisen, Rene" sort="Feyereisen, Rene" uniqKey="Feyereisen R" first="René" last="Feyereisen">René Feyereisen</name><affiliation><nlm:aff id="A42">Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Grimmelikhuijzen, Cornelis J P" sort="Grimmelikhuijzen, Cornelis J P" uniqKey="Grimmelikhuijzen C" first="Cornelis J. P" last="Grimmelikhuijzen">Cornelis J. P Grimmelikhuijzen</name><affiliation><nlm:aff id="A24">Center for Functional and Comparative Insect Genomics, Department of Biology, University of Copenhagen, Universitetsparken 15, DK-21oo, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hamodrakas, Stavros J" sort="Hamodrakas, Stavros J" uniqKey="Hamodrakas S" first="Stavros J." last="Hamodrakas">Stavros J. Hamodrakas</name><affiliation><nlm:aff id="A43">Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Hansson, Bill S" sort="Hansson, Bill S" uniqKey="Hansson B" first="Bill S." last="Hansson">Bill S. Hansson</name><affiliation><nlm:aff id="A7">Max Planck Institute for Chemical Ecology, Department of Evolutionary Neuroethology, Hans-Knoell-Strasse, 8, D-07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Huguet, Elisabeth" sort="Huguet, Elisabeth" uniqKey="Huguet E" first="Elisabeth" last="Huguet">Elisabeth Huguet</name><affiliation><nlm:aff id="A19">Institut de Recherche sur la Biologie de l’Insecte, UMR CNRS 7261, UFR Sciences et Techniques, Université François-Rabelais, Tours, France</nlm:aff></affiliation></author><author><name sortKey="Jermiin, Lars S" sort="Jermiin, Lars S" uniqKey="Jermiin L" first="Lars S." last="Jermiin">Lars S. Jermiin</name><affiliation><nlm:aff id="A20">CSIRO Land and Water, Clunies Ross St, Acton, ACT, 2601, Australia</nlm:aff></affiliation></author><author><name sortKey="Lan, Que" sort="Lan, Que" uniqKey="Lan Q" first="Que" last="Lan">Que Lan</name><affiliation><nlm:aff id="A44">Department of Entomology, University of Wisconsin, Madison, USA</nlm:aff></affiliation></author><author><name sortKey="Lehman, Herman K" sort="Lehman, Herman K" uniqKey="Lehman H" first="Herman K." last="Lehman">Herman K. Lehman</name><affiliation><nlm:aff id="A45">Biology Department and Neuroscience Program, Hamilton College, Clinton, NY, 13323, USA</nlm:aff></affiliation></author><author><name sortKey="Lorenzen, Marce" sort="Lorenzen, Marce" uniqKey="Lorenzen M" first="Marce" last="Lorenzen">Marce Lorenzen</name><affiliation><nlm:aff id="A46">Dept. Entomology, North Carolina State Univ., Raleigh, NC, 27695, USA</nlm:aff></affiliation></author><author><name sortKey="Merzendorfer, Hans" sort="Merzendorfer, Hans" uniqKey="Merzendorfer H" first="Hans" last="Merzendorfer">Hans Merzendorfer</name><affiliation><nlm:aff id="A47">University of Siegen, School of Natural Sciences and Engineering, Institute of Biology – Molecular Biology, Adolf-Reichwein-Strasse. 2, AR-C3010, 57076 Siegen, Germany</nlm:aff></affiliation></author><author><name sortKey="Michalopoulos, Ioannis" sort="Michalopoulos, Ioannis" uniqKey="Michalopoulos I" first="Ioannis" last="Michalopoulos">Ioannis Michalopoulos</name><affiliation><nlm:aff id="A22">Centre of Systems Biology, Biomedical Research Foundation, Academy of Athens, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Morton, David B" sort="Morton, David B" uniqKey="Morton D" first="David B." last="Morton">David B. Morton</name><affiliation><nlm:aff id="A48">Department of Integrative Biosciences, School of Dentistry, BRB421, L595, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA</nlm:aff></affiliation></author><author><name sortKey="Muthukrishnan, Subbaratnam" sort="Muthukrishnan, Subbaratnam" uniqKey="Muthukrishnan S" first="Subbaratnam" last="Muthukrishnan">Subbaratnam Muthukrishnan</name><affiliation><nlm:aff id="A1">Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Oakeshott, John G" sort="Oakeshott, John G" uniqKey="Oakeshott J" first="John G." last="Oakeshott">John G. Oakeshott</name><affiliation><nlm:aff id="A20">CSIRO Land and Water, Clunies Ross St, Acton, ACT, 2601, Australia</nlm:aff></affiliation></author><author><name sortKey="Palmer, Will" sort="Palmer, Will" uniqKey="Palmer W" first="Will" last="Palmer">Will Palmer</name><affiliation><nlm:aff id="A49">Department of Genetics, University of Cambridge, Downing St, Cambridge, CB2 3EH, UK</nlm:aff></affiliation></author><author><name sortKey="Park, Yoonseong" sort="Park, Yoonseong" uniqKey="Park Y" first="Yoonseong" last="Park">Yoonseong Park</name><affiliation><nlm:aff id="A50">Department of Entomology, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Passarelli, A Lorena" sort="Passarelli, A Lorena" uniqKey="Passarelli A" first="A. Lorena" last="Passarelli">A. Lorena Passarelli</name><affiliation><nlm:aff id="A18">Division of Biology, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Rozas, Julio" sort="Rozas, Julio" uniqKey="Rozas J" first="Julio" last="Rozas">Julio Rozas</name><affiliation><nlm:aff id="A16">Department de Genètica and Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Schwartz, Lawrence M" sort="Schwartz, Lawrence M" uniqKey="Schwartz L" first="Lawrence M." last="Schwartz">Lawrence M. Schwartz</name><affiliation><nlm:aff id="A51">Department of Biology, University of Massachusetts, Amherst, MA, 01003, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, Wendy" sort="Smith, Wendy" uniqKey="Smith W" first="Wendy" last="Smith">Wendy Smith</name><affiliation><nlm:aff id="A52">Department of Biology, Northeastern University, Boston, MA, 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Southgate, Agnes" sort="Southgate, Agnes" uniqKey="Southgate A" first="Agnes" last="Southgate">Agnes Southgate</name><affiliation><nlm:aff id="A53">Department of Biology, College of Charleston, Charleston, SC, 29424, USA</nlm:aff></affiliation></author><author><name sortKey="Vilcinskas, Andreas" sort="Vilcinskas, Andreas" uniqKey="Vilcinskas A" first="Andreas" last="Vilcinskas">Andreas Vilcinskas</name><affiliation><nlm:aff id="A54">Institute for Insect Biotechnology, Justus-Liebig-University, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany</nlm:aff></affiliation></author><author><name sortKey="Vogt, Richard" sort="Vogt, Richard" uniqKey="Vogt R" first="Richard" last="Vogt">Richard Vogt</name><affiliation><nlm:aff id="A55">Department of Biological Sciences, University of South Carolina, Columbia, SC, 29205, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Ping" sort="Wang, Ping" uniqKey="Wang P" first="Ping" last="Wang">Ping Wang</name><affiliation><nlm:aff id="A37">Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY, 14456, USA</nlm:aff></affiliation></author><author><name sortKey="Werren, John" sort="Werren, John" uniqKey="Werren J" first="John" last="Werren">John Werren</name><affiliation><nlm:aff id="A35">Department of Biology, University of Rochester, Rochester, NY, 14627, USA</nlm:aff></affiliation></author><author><name sortKey="Yu, Xiao Qiang" sort="Yu, Xiao Qiang" uniqKey="Yu X" first="Xiao-Qiang" last="Yu">Xiao-Qiang Yu</name><affiliation><nlm:aff id="A56">University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO, 64110, USA</nlm:aff></affiliation></author><author><name sortKey="Zhou, Jing Jiang" sort="Zhou, Jing Jiang" uniqKey="Zhou J" first="Jing-Jiang" last="Zhou">Jing-Jiang Zhou</name><affiliation><nlm:aff id="A57">Department of Biological Chemistry and Crop Protection, Rothamsted Research, Harpenden, Herts, AL5 2JQ, UK</nlm:aff></affiliation></author><author><name sortKey="Brown, Susan J" sort="Brown, Susan J" uniqKey="Brown S" first="Susan J." last="Brown">Susan J. Brown</name><affiliation><nlm:aff id="A5">KSU Bioinformatics Center, Division of Biology, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Scherer, Steven E" sort="Scherer, Steven E" uniqKey="Scherer S" first="Steven E." last="Scherer">Steven E. Scherer</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Richards, Stephen" sort="Richards, Stephen" uniqKey="Richards S" first="Stephen" last="Richards">Stephen Richards</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Blissard, Gary W" sort="Blissard, Gary W" uniqKey="Blissard G" first="Gary W." last="Blissard">Gary W. Blissard</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27522922</idno><idno type="pmc">5010457</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010457</idno><idno type="RBID">PMC:5010457</idno><idno type="doi">10.1016/j.ibmb.2016.07.005</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002104</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002104</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, <italic>Manduca sexta</italic></title><author><name sortKey="Kanost, Michael R" sort="Kanost, Michael R" uniqKey="Kanost M" first="Michael R." last="Kanost">Michael R. Kanost</name><affiliation><nlm:aff id="A1">Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Arrese, Estela L" sort="Arrese, Estela L" uniqKey="Arrese E" first="Estela L." last="Arrese">Estela L. Arrese</name><affiliation><nlm:aff id="A2">Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Cao, Xiaolong" sort="Cao, Xiaolong" uniqKey="Cao X" first="Xiaolong" last="Cao">Xiaolong Cao</name><affiliation><nlm:aff id="A3">Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Yun Ru" sort="Chen, Yun Ru" uniqKey="Chen Y" first="Yun-Ru" last="Chen">Yun-Ru Chen</name><affiliation><nlm:aff id="A4">Boyce Thompson Institute at Cornell University, Tower Road Ithaca, NY, 14853, USA</nlm:aff></affiliation></author><author><name sortKey="Chellapilla, Sanjay" sort="Chellapilla, Sanjay" uniqKey="Chellapilla S" first="Sanjay" last="Chellapilla">Sanjay Chellapilla</name><affiliation><nlm:aff id="A5">KSU Bioinformatics Center, Division of Biology, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Goldsmith, Marian R" sort="Goldsmith, Marian R" uniqKey="Goldsmith M" first="Marian R" last="Goldsmith">Marian R. Goldsmith</name><affiliation><nlm:aff id="A6">Biological Sciences Department, University of Rhode Island, Kingston, RI, 02881, USA</nlm:aff></affiliation></author><author><name sortKey="Grosse Wilde, Ewald" sort="Grosse Wilde, Ewald" uniqKey="Grosse Wilde E" first="Ewald" last="Grosse-Wilde">Ewald Grosse-Wilde</name><affiliation><nlm:aff id="A7">Max Planck Institute for Chemical Ecology, Department of Evolutionary Neuroethology, Hans-Knoell-Strasse, 8, D-07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Heckel, David G" sort="Heckel, David G" uniqKey="Heckel D" first="David G." last="Heckel">David G. Heckel</name><affiliation><nlm:aff id="A8">Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Herndon, Nicolae" sort="Herndon, Nicolae" uniqKey="Herndon N" first="Nicolae" last="Herndon">Nicolae Herndon</name><affiliation><nlm:aff id="A5">KSU Bioinformatics Center, Division of Biology, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Jiang, Haobo" sort="Jiang, Haobo" uniqKey="Jiang H" first="Haobo" last="Jiang">Haobo Jiang</name><affiliation><nlm:aff id="A3">Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Papanicolaou, Alexie" sort="Papanicolaou, Alexie" uniqKey="Papanicolaou A" first="Alexie" last="Papanicolaou">Alexie Papanicolaou</name><affiliation><nlm:aff id="A9">Hawkesbury Institute for the Environment, Western Sydney University, Richmond, NSW, 2753, Australia</nlm:aff></affiliation></author><author><name sortKey="Qu, Jiaxin" sort="Qu, Jiaxin" uniqKey="Qu J" first="Jiaxin" last="Qu">Jiaxin Qu</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Soulages, Jose L" sort="Soulages, Jose L" uniqKey="Soulages J" first="Jose L." last="Soulages">Jose L. Soulages</name><affiliation><nlm:aff id="A2">Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Vogel, Heiko" sort="Vogel, Heiko" uniqKey="Vogel H" first="Heiko" last="Vogel">Heiko Vogel</name><affiliation><nlm:aff id="A8">Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Walters, James" sort="Walters, James" uniqKey="Walters J" first="James" last="Walters">James Walters</name><affiliation><nlm:aff id="A11">Department of Ecology and Evolutionary Biology, Univ. Kansas, Lawrence, KS, 66045, USA</nlm:aff></affiliation></author><author><name sortKey="Waterhouse, Robert M" sort="Waterhouse, Robert M" uniqKey="Waterhouse R" first="Robert M." last="Waterhouse">Robert M. Waterhouse</name><affiliation><nlm:aff id="A12">Department of Genetic Medicine and Development, University of Geneva Medical School, rue Michel-Servet 1, 1211, Geneva, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Swiss Institute of Bioinformatics, rue Michel-Servet 1, 1211, Geneva, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA, 02139, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A15">The Broad Institute of MIT and Harvard, Cambridge, 415 Main Street, MA, 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Ahn, Seung Joon" sort="Ahn, Seung Joon" uniqKey="Ahn S" first="Seung-Joon" last="Ahn">Seung-Joon Ahn</name><affiliation><nlm:aff id="A8">Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Almeida, Francisca C" sort="Almeida, Francisca C" uniqKey="Almeida F" first="Francisca C." last="Almeida">Francisca C. Almeida</name><affiliation><nlm:aff id="A16">Department de Genètica and Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="An, Chunju" sort="An, Chunju" uniqKey="An C" first="Chunju" last="An">Chunju An</name><affiliation><nlm:aff id="A17">Department of Entomology, China Agricultural University, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Aqrawi, Peshtewani" sort="Aqrawi, Peshtewani" uniqKey="Aqrawi P" first="Peshtewani" last="Aqrawi">Peshtewani Aqrawi</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Bretschneider, Anne" sort="Bretschneider, Anne" uniqKey="Bretschneider A" first="Anne" last="Bretschneider">Anne Bretschneider</name><affiliation><nlm:aff id="A8">Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Bryant, William B" sort="Bryant, William B" uniqKey="Bryant W" first="William B." last="Bryant">William B. Bryant</name><affiliation><nlm:aff id="A18">Division of Biology, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Bucks, Sascha" sort="Bucks, Sascha" uniqKey="Bucks S" first="Sascha" last="Bucks">Sascha Bucks</name><affiliation><nlm:aff id="A7">Max Planck Institute for Chemical Ecology, Department of Evolutionary Neuroethology, Hans-Knoell-Strasse, 8, D-07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Chao, Hsu" sort="Chao, Hsu" uniqKey="Chao H" first="Hsu" last="Chao">Hsu Chao</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Chevignon, Germain" sort="Chevignon, Germain" uniqKey="Chevignon G" first="Germain" last="Chevignon">Germain Chevignon</name><affiliation><nlm:aff id="A19">Institut de Recherche sur la Biologie de l’Insecte, UMR CNRS 7261, UFR Sciences et Techniques, Université François-Rabelais, Tours, France</nlm:aff></affiliation></author><author><name sortKey="Christen, Jayne M" sort="Christen, Jayne M" uniqKey="Christen J" first="Jayne M." last="Christen">Jayne M. Christen</name><affiliation><nlm:aff id="A1">Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Clarke, David F" sort="Clarke, David F" uniqKey="Clarke D" first="David F." last="Clarke">David F. Clarke</name><affiliation><nlm:aff id="A20">CSIRO Land and Water, Clunies Ross St, Acton, ACT, 2601, Australia</nlm:aff></affiliation></author><author><name sortKey="Dittmer, Neal T" sort="Dittmer, Neal T" uniqKey="Dittmer N" first="Neal T." last="Dittmer">Neal T. Dittmer</name><affiliation><nlm:aff id="A1">Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Ferguson, Laura C F" sort="Ferguson, Laura C F" uniqKey="Ferguson L" first="Laura C. F." last="Ferguson">Laura C. F. Ferguson</name><affiliation><nlm:aff id="A21">Department of Zoology, South Parks Road, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Garavelou, Spyridoula" sort="Garavelou, Spyridoula" uniqKey="Garavelou S" first="Spyridoula" last="Garavelou">Spyridoula Garavelou</name><affiliation><nlm:aff id="A22">Centre of Systems Biology, Biomedical Research Foundation, Academy of Athens, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Gordon, Karl H J" sort="Gordon, Karl H J" uniqKey="Gordon K" first="Karl H. J." last="Gordon">Karl H. J. Gordon</name><affiliation><nlm:aff id="A23">CSIRO Health and Biosecurity, Clunies Ross St, Acton, ACT, 2601, Australia</nlm:aff></affiliation></author><author><name sortKey="Gunaratna, Ramesh T" sort="Gunaratna, Ramesh T" uniqKey="Gunaratna R" first="Ramesh T." last="Gunaratna">Ramesh T. Gunaratna</name><affiliation><nlm:aff id="A3">Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Han, Yi" sort="Han, Yi" uniqKey="Han Y" first="Yi" last="Han">Yi Han</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Hauser, Frank" sort="Hauser, Frank" uniqKey="Hauser F" first="Frank" last="Hauser">Frank Hauser</name><affiliation><nlm:aff id="A24">Center for Functional and Comparative Insect Genomics, Department of Biology, University of Copenhagen, Universitetsparken 15, DK-21oo, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="He, Yan" sort="He, Yan" uniqKey="He Y" first="Yan" last="He">Yan He</name><affiliation><nlm:aff id="A3">Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Heidel Fischer, Hanna" sort="Heidel Fischer, Hanna" uniqKey="Heidel Fischer H" first="Hanna" last="Heidel-Fischer">Hanna Heidel-Fischer</name><affiliation><nlm:aff id="A8">Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Hirsh, Ariana" sort="Hirsh, Ariana" uniqKey="Hirsh A" first="Ariana" last="Hirsh">Ariana Hirsh</name><affiliation><nlm:aff id="A25">Department of Biology, Barnard College, Columbia University, 3009 Broadway, New York, NY, 10027, USA</nlm:aff></affiliation></author><author><name sortKey="Hu, Yingxia" sort="Hu, Yingxia" uniqKey="Hu Y" first="Yingxia" last="Hu">Yingxia Hu</name><affiliation><nlm:aff id="A3">Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Jiang, Hongbo" sort="Jiang, Hongbo" uniqKey="Jiang H" first="Hongbo" last="Jiang">Hongbo Jiang</name><affiliation><nlm:aff id="A26">Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing, 400715, China</nlm:aff></affiliation></author><author><name sortKey="Kalra, Divya" sort="Kalra, Divya" uniqKey="Kalra D" first="Divya" last="Kalra">Divya Kalra</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Klinner, Christian" sort="Klinner, Christian" uniqKey="Klinner C" first="Christian" last="Klinner">Christian Klinner</name><affiliation><nlm:aff id="A7">Max Planck Institute for Chemical Ecology, Department of Evolutionary Neuroethology, Hans-Knoell-Strasse, 8, D-07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Konig, Christopher" sort="Konig, Christopher" uniqKey="Konig C" first="Christopher" last="König">Christopher König</name><affiliation><nlm:aff id="A7">Max Planck Institute for Chemical Ecology, Department of Evolutionary Neuroethology, Hans-Knoell-Strasse, 8, D-07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Kovar, Christie" sort="Kovar, Christie" uniqKey="Kovar C" first="Christie" last="Kovar">Christie Kovar</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Kroll, Ashley R" sort="Kroll, Ashley R" uniqKey="Kroll A" first="Ashley R." last="Kroll">Ashley R. Kroll</name><affiliation><nlm:aff id="A27">Department of Biology, Reed College, Portland, OR, 97202, USA</nlm:aff></affiliation></author><author><name sortKey="Kuwar, Suyog S" sort="Kuwar, Suyog S" uniqKey="Kuwar S" first="Suyog S." last="Kuwar">Suyog S. Kuwar</name><affiliation><nlm:aff id="A8">Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Lee, Sandy L" sort="Lee, Sandy L" uniqKey="Lee S" first="Sandy L." last="Lee">Sandy L. Lee</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Lehman, Rudiger" sort="Lehman, Rudiger" uniqKey="Lehman R" first="Rüdiger" last="Lehman">Rüdiger Lehman</name><affiliation><nlm:aff id="A28">Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Bioresources Project Group, Winchesterstrasse 2, 35394, Gießen, Germany</nlm:aff></affiliation></author><author><name sortKey="Li, Kai" sort="Li, Kai" uniqKey="Li K" first="Kai" last="Li">Kai Li</name><affiliation><nlm:aff id="A29">College of Chemistry, Chemical Engineering, and Biotechnology, Donghua University, Shanghai, 201620, China</nlm:aff></affiliation></author><author><name sortKey="Li, Zhaofei" sort="Li, Zhaofei" uniqKey="Li Z" first="Zhaofei" last="Li">Zhaofei Li</name><affiliation><nlm:aff id="A30">College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, China</nlm:aff></affiliation></author><author><name sortKey="Liang, Hanquan" sort="Liang, Hanquan" uniqKey="Liang H" first="Hanquan" last="Liang">Hanquan Liang</name><affiliation><nlm:aff id="A31">McDermott Center for Human Growth and Development, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA</nlm:aff></affiliation></author><author><name sortKey="Lovelace, Shanna" sort="Lovelace, Shanna" uniqKey="Lovelace S" first="Shanna" last="Lovelace">Shanna Lovelace</name><affiliation><nlm:aff id="A32">Department of Biological Sciences, University of Southern Maine, Portland, ME, 04104, USA</nlm:aff></affiliation></author><author><name sortKey="Lu, Zhiqiang" sort="Lu, Zhiqiang" uniqKey="Lu Z" first="Zhiqiang" last="Lu">Zhiqiang Lu</name><affiliation><nlm:aff id="A30">College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, China</nlm:aff></affiliation></author><author><name sortKey="Mansfield, Jennifer H" sort="Mansfield, Jennifer H" uniqKey="Mansfield J" first="Jennifer H." last="Mansfield">Jennifer H. Mansfield</name><affiliation><nlm:aff id="A25">Department of Biology, Barnard College, Columbia University, 3009 Broadway, New York, NY, 10027, USA</nlm:aff></affiliation></author><author><name sortKey="Mcculloch, Kyle J" sort="Mcculloch, Kyle J" uniqKey="Mcculloch K" first="Kyle J." last="Mcculloch">Kyle J. Mcculloch</name><affiliation><nlm:aff id="A33">Department of Ecology and Evolutionary Biology, University of California, Irvine, CA, 92697, USA</nlm:aff></affiliation></author><author><name sortKey="Mathew, Tittu" sort="Mathew, Tittu" uniqKey="Mathew T" first="Tittu" last="Mathew">Tittu Mathew</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Morton, Brian" sort="Morton, Brian" uniqKey="Morton B" first="Brian" last="Morton">Brian Morton</name><affiliation><nlm:aff id="A25">Department of Biology, Barnard College, Columbia University, 3009 Broadway, New York, NY, 10027, USA</nlm:aff></affiliation></author><author><name sortKey="Muzny, Donna M" sort="Muzny, Donna M" uniqKey="Muzny D" first="Donna M." last="Muzny">Donna M. Muzny</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Neunemann, David" sort="Neunemann, David" uniqKey="Neunemann D" first="David" last="Neunemann">David Neunemann</name><affiliation><nlm:aff id="A8">Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Ongeri, Fiona" sort="Ongeri, Fiona" uniqKey="Ongeri F" first="Fiona" last="Ongeri">Fiona Ongeri</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Pauchet, Yannick" sort="Pauchet, Yannick" uniqKey="Pauchet Y" first="Yannick" last="Pauchet">Yannick Pauchet</name><affiliation><nlm:aff id="A8">Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Pu, Ling Ling" sort="Pu, Ling Ling" uniqKey="Pu L" first="Ling-Ling" last="Pu">Ling-Ling Pu</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Pyrousis, Ioannis" sort="Pyrousis, Ioannis" uniqKey="Pyrousis I" first="Ioannis" last="Pyrousis">Ioannis Pyrousis</name><affiliation><nlm:aff id="A22">Centre of Systems Biology, Biomedical Research Foundation, Academy of Athens, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Rao, Xiang Jun" sort="Rao, Xiang Jun" uniqKey="Rao X" first="Xiang-Jun" last="Rao">Xiang-Jun Rao</name><affiliation><nlm:aff id="A34">School of Plant Protection, Anhui Agricultural University, Hefei, Anhui, China</nlm:aff></affiliation></author><author><name sortKey="Redding, Amanda" sort="Redding, Amanda" uniqKey="Redding A" first="Amanda" last="Redding">Amanda Redding</name><affiliation><nlm:aff id="A35">Department of Biology, University of Rochester, Rochester, NY, 14627, USA</nlm:aff></affiliation></author><author><name sortKey="Roesel, Charles" sort="Roesel, Charles" uniqKey="Roesel C" first="Charles" last="Roesel">Charles Roesel</name><affiliation><nlm:aff id="A36">Department of Marine and Environmental Sciences, Northeastern University, Boston, MA, 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Sanchez Gracia, Alejandro" sort="Sanchez Gracia, Alejandro" uniqKey="Sanchez Gracia A" first="Alejandro" last="Sanchez-Gracia">Alejandro Sanchez-Gracia</name><affiliation><nlm:aff id="A16">Department de Genètica and Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Schaack, Sarah" sort="Schaack, Sarah" uniqKey="Schaack S" first="Sarah" last="Schaack">Sarah Schaack</name><affiliation><nlm:aff id="A27">Department of Biology, Reed College, Portland, OR, 97202, USA</nlm:aff></affiliation></author><author><name sortKey="Shukla, Aditi" sort="Shukla, Aditi" uniqKey="Shukla A" first="Aditi" last="Shukla">Aditi Shukla</name><affiliation><nlm:aff id="A25">Department of Biology, Barnard College, Columbia University, 3009 Broadway, New York, NY, 10027, USA</nlm:aff></affiliation></author><author><name sortKey="Tetreau, Guillaume" sort="Tetreau, Guillaume" uniqKey="Tetreau G" first="Guillaume" last="Tetreau">Guillaume Tetreau</name><affiliation><nlm:aff id="A37">Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY, 14456, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Yang" sort="Wang, Yang" uniqKey="Wang Y" first="Yang" last="Wang">Yang Wang</name><affiliation><nlm:aff id="A3">Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Xiong, Guang Hua" sort="Xiong, Guang Hua" uniqKey="Xiong G" first="Guang-Hua" last="Xiong">Guang-Hua Xiong</name><affiliation><nlm:aff id="A38">State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Traut, Walther" sort="Traut, Walther" uniqKey="Traut W" first="Walther" last="Traut">Walther Traut</name><affiliation><nlm:aff id="A39">Institut fuer Biologie, Universitaet Luebeck, D-23538, Luebeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Walsh, Tom K" sort="Walsh, Tom K" uniqKey="Walsh T" first="Tom K." last="Walsh">Tom K. Walsh</name><affiliation><nlm:aff id="A20">CSIRO Land and Water, Clunies Ross St, Acton, ACT, 2601, Australia</nlm:aff></affiliation></author><author><name sortKey="Worley, Kim C" sort="Worley, Kim C" uniqKey="Worley K" first="Kim C." last="Worley">Kim C. Worley</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Wu, Di" sort="Wu, Di" uniqKey="Wu D" first="Di" last="Wu">Di Wu</name><affiliation><nlm:aff id="A1">Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Wu, Wenbi" sort="Wu, Wenbi" uniqKey="Wu W" first="Wenbi" last="Wu">Wenbi Wu</name><affiliation><nlm:aff id="A18">Division of Biology, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Wu, Yuan Qing" sort="Wu, Yuan Qing" uniqKey="Wu Y" first="Yuan-Qing" last="Wu">Yuan-Qing Wu</name></author><author><name sortKey="Zhang, Xiufeng" sort="Zhang, Xiufeng" uniqKey="Zhang X" first="Xiufeng" last="Zhang">Xiufeng Zhang</name><affiliation><nlm:aff id="A3">Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, 74078, USA</nlm:aff></affiliation></author><author><name sortKey="Zou, Zhen" sort="Zou, Zhen" uniqKey="Zou Z" first="Zhen" last="Zou">Zhen Zou</name><affiliation><nlm:aff id="A38">State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Zucker, Hannah" sort="Zucker, Hannah" uniqKey="Zucker H" first="Hannah" last="Zucker">Hannah Zucker</name><affiliation><nlm:aff id="A40">Neuroscience Program, Hamilton College, Clinton, NY, 13323, USA</nlm:aff></affiliation></author><author><name sortKey="Briscoe, Adriana D" sort="Briscoe, Adriana D" uniqKey="Briscoe A" first="Adriana D." last="Briscoe">Adriana D. Briscoe</name><affiliation><nlm:aff id="A33">Department of Ecology and Evolutionary Biology, University of California, Irvine, CA, 92697, USA</nlm:aff></affiliation></author><author><name sortKey="Burmester, Thorsten" sort="Burmester, Thorsten" uniqKey="Burmester T" first="Thorsten" last="Burmester">Thorsten Burmester</name><affiliation><nlm:aff id="A41">Institute of Zoology, University of Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Clem, Rollie J" sort="Clem, Rollie J" uniqKey="Clem R" first="Rollie J." last="Clem">Rollie J. Clem</name><affiliation><nlm:aff id="A18">Division of Biology, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Feyereisen, Rene" sort="Feyereisen, Rene" uniqKey="Feyereisen R" first="René" last="Feyereisen">René Feyereisen</name><affiliation><nlm:aff id="A42">Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Grimmelikhuijzen, Cornelis J P" sort="Grimmelikhuijzen, Cornelis J P" uniqKey="Grimmelikhuijzen C" first="Cornelis J. P" last="Grimmelikhuijzen">Cornelis J. P Grimmelikhuijzen</name><affiliation><nlm:aff id="A24">Center for Functional and Comparative Insect Genomics, Department of Biology, University of Copenhagen, Universitetsparken 15, DK-21oo, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hamodrakas, Stavros J" sort="Hamodrakas, Stavros J" uniqKey="Hamodrakas S" first="Stavros J." last="Hamodrakas">Stavros J. Hamodrakas</name><affiliation><nlm:aff id="A43">Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Hansson, Bill S" sort="Hansson, Bill S" uniqKey="Hansson B" first="Bill S." last="Hansson">Bill S. Hansson</name><affiliation><nlm:aff id="A7">Max Planck Institute for Chemical Ecology, Department of Evolutionary Neuroethology, Hans-Knoell-Strasse, 8, D-07745, Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Huguet, Elisabeth" sort="Huguet, Elisabeth" uniqKey="Huguet E" first="Elisabeth" last="Huguet">Elisabeth Huguet</name><affiliation><nlm:aff id="A19">Institut de Recherche sur la Biologie de l’Insecte, UMR CNRS 7261, UFR Sciences et Techniques, Université François-Rabelais, Tours, France</nlm:aff></affiliation></author><author><name sortKey="Jermiin, Lars S" sort="Jermiin, Lars S" uniqKey="Jermiin L" first="Lars S." last="Jermiin">Lars S. Jermiin</name><affiliation><nlm:aff id="A20">CSIRO Land and Water, Clunies Ross St, Acton, ACT, 2601, Australia</nlm:aff></affiliation></author><author><name sortKey="Lan, Que" sort="Lan, Que" uniqKey="Lan Q" first="Que" last="Lan">Que Lan</name><affiliation><nlm:aff id="A44">Department of Entomology, University of Wisconsin, Madison, USA</nlm:aff></affiliation></author><author><name sortKey="Lehman, Herman K" sort="Lehman, Herman K" uniqKey="Lehman H" first="Herman K." last="Lehman">Herman K. Lehman</name><affiliation><nlm:aff id="A45">Biology Department and Neuroscience Program, Hamilton College, Clinton, NY, 13323, USA</nlm:aff></affiliation></author><author><name sortKey="Lorenzen, Marce" sort="Lorenzen, Marce" uniqKey="Lorenzen M" first="Marce" last="Lorenzen">Marce Lorenzen</name><affiliation><nlm:aff id="A46">Dept. Entomology, North Carolina State Univ., Raleigh, NC, 27695, USA</nlm:aff></affiliation></author><author><name sortKey="Merzendorfer, Hans" sort="Merzendorfer, Hans" uniqKey="Merzendorfer H" first="Hans" last="Merzendorfer">Hans Merzendorfer</name><affiliation><nlm:aff id="A47">University of Siegen, School of Natural Sciences and Engineering, Institute of Biology – Molecular Biology, Adolf-Reichwein-Strasse. 2, AR-C3010, 57076 Siegen, Germany</nlm:aff></affiliation></author><author><name sortKey="Michalopoulos, Ioannis" sort="Michalopoulos, Ioannis" uniqKey="Michalopoulos I" first="Ioannis" last="Michalopoulos">Ioannis Michalopoulos</name><affiliation><nlm:aff id="A22">Centre of Systems Biology, Biomedical Research Foundation, Academy of Athens, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Morton, David B" sort="Morton, David B" uniqKey="Morton D" first="David B." last="Morton">David B. Morton</name><affiliation><nlm:aff id="A48">Department of Integrative Biosciences, School of Dentistry, BRB421, L595, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA</nlm:aff></affiliation></author><author><name sortKey="Muthukrishnan, Subbaratnam" sort="Muthukrishnan, Subbaratnam" uniqKey="Muthukrishnan S" first="Subbaratnam" last="Muthukrishnan">Subbaratnam Muthukrishnan</name><affiliation><nlm:aff id="A1">Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Oakeshott, John G" sort="Oakeshott, John G" uniqKey="Oakeshott J" first="John G." last="Oakeshott">John G. Oakeshott</name><affiliation><nlm:aff id="A20">CSIRO Land and Water, Clunies Ross St, Acton, ACT, 2601, Australia</nlm:aff></affiliation></author><author><name sortKey="Palmer, Will" sort="Palmer, Will" uniqKey="Palmer W" first="Will" last="Palmer">Will Palmer</name><affiliation><nlm:aff id="A49">Department of Genetics, University of Cambridge, Downing St, Cambridge, CB2 3EH, UK</nlm:aff></affiliation></author><author><name sortKey="Park, Yoonseong" sort="Park, Yoonseong" uniqKey="Park Y" first="Yoonseong" last="Park">Yoonseong Park</name><affiliation><nlm:aff id="A50">Department of Entomology, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Passarelli, A Lorena" sort="Passarelli, A Lorena" uniqKey="Passarelli A" first="A. Lorena" last="Passarelli">A. Lorena Passarelli</name><affiliation><nlm:aff id="A18">Division of Biology, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Rozas, Julio" sort="Rozas, Julio" uniqKey="Rozas J" first="Julio" last="Rozas">Julio Rozas</name><affiliation><nlm:aff id="A16">Department de Genètica and Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Schwartz, Lawrence M" sort="Schwartz, Lawrence M" uniqKey="Schwartz L" first="Lawrence M." last="Schwartz">Lawrence M. Schwartz</name><affiliation><nlm:aff id="A51">Department of Biology, University of Massachusetts, Amherst, MA, 01003, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, Wendy" sort="Smith, Wendy" uniqKey="Smith W" first="Wendy" last="Smith">Wendy Smith</name><affiliation><nlm:aff id="A52">Department of Biology, Northeastern University, Boston, MA, 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Southgate, Agnes" sort="Southgate, Agnes" uniqKey="Southgate A" first="Agnes" last="Southgate">Agnes Southgate</name><affiliation><nlm:aff id="A53">Department of Biology, College of Charleston, Charleston, SC, 29424, USA</nlm:aff></affiliation></author><author><name sortKey="Vilcinskas, Andreas" sort="Vilcinskas, Andreas" uniqKey="Vilcinskas A" first="Andreas" last="Vilcinskas">Andreas Vilcinskas</name><affiliation><nlm:aff id="A54">Institute for Insect Biotechnology, Justus-Liebig-University, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany</nlm:aff></affiliation></author><author><name sortKey="Vogt, Richard" sort="Vogt, Richard" uniqKey="Vogt R" first="Richard" last="Vogt">Richard Vogt</name><affiliation><nlm:aff id="A55">Department of Biological Sciences, University of South Carolina, Columbia, SC, 29205, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Ping" sort="Wang, Ping" uniqKey="Wang P" first="Ping" last="Wang">Ping Wang</name><affiliation><nlm:aff id="A37">Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY, 14456, USA</nlm:aff></affiliation></author><author><name sortKey="Werren, John" sort="Werren, John" uniqKey="Werren J" first="John" last="Werren">John Werren</name><affiliation><nlm:aff id="A35">Department of Biology, University of Rochester, Rochester, NY, 14627, USA</nlm:aff></affiliation></author><author><name sortKey="Yu, Xiao Qiang" sort="Yu, Xiao Qiang" uniqKey="Yu X" first="Xiao-Qiang" last="Yu">Xiao-Qiang Yu</name><affiliation><nlm:aff id="A56">University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO, 64110, USA</nlm:aff></affiliation></author><author><name sortKey="Zhou, Jing Jiang" sort="Zhou, Jing Jiang" uniqKey="Zhou J" first="Jing-Jiang" last="Zhou">Jing-Jiang Zhou</name><affiliation><nlm:aff id="A57">Department of Biological Chemistry and Crop Protection, Rothamsted Research, Harpenden, Herts, AL5 2JQ, UK</nlm:aff></affiliation></author><author><name sortKey="Brown, Susan J" sort="Brown, Susan J" uniqKey="Brown S" first="Susan J." last="Brown">Susan J. Brown</name><affiliation><nlm:aff id="A5">KSU Bioinformatics Center, Division of Biology, Kansas State University, Manhattan, KS, 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Scherer, Steven E" sort="Scherer, Steven E" uniqKey="Scherer S" first="Steven E." last="Scherer">Steven E. Scherer</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Richards, Stephen" sort="Richards, Stephen" uniqKey="Richards S" first="Stephen" last="Richards">Stephen Richards</name><affiliation><nlm:aff id="A10">Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Blissard, Gary W" sort="Blissard, Gary W" uniqKey="Blissard G" first="Gary W." last="Blissard">Gary W. Blissard</name></author></analytic><series><title level="j">Insect biochemistry and molecular biology</title><idno type="ISSN">0965-1748</idno><idno type="eISSN">1879-0240</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3"><italic>Manduca sexta</italic>, known as the tobacco hornworm or Carolina sphinx moth, is a lepidopteran insect that is used extensively as a model system for research in insect biochemistry, physiology, neurobiology, development, and immunity. One important benefit of this species as an experimental model is its extremely large size, reaching more than 10 g in the larval stage. <italic>M. sexta</italic> larvae feed on solanaceous plants and thus must tolerate a substantial challenge from plant allelochemicals, including nicotine. We report the sequence and annotation of the <italic>M. sexta</italic> genome, and a survey of gene expression in various tissues and developmental stages. The Msex_1.0 genome assembly resulted in a total genome size of 419.4 Mbp. Repetitive sequences accounted for 25.8% of the assembled genome. The official gene set is comprised of 15,451 protein-coding genes, of which 2498 were manually curated. Extensive RNA-seq data from many tissues and developmental stages were used to improve gene models and for insights into gene expression patterns. Genome wide synteny analysis indicated a high level of macrosynteny in the Lepidoptera. Annotation and analyses were carried out for gene families involved in a wide spectrum of biological processes, including apoptosis, vacuole sorting, growth and development, structures of exoskeleton, egg shells, and muscle, vision, chemosensation, ion channels, signal transduction, neuropeptide signaling, neurotransmitter synthesis and transport, nicotine tolerance, lipid metabolism, and immunity. This genome sequence, annotation, and analysis provide an important new resource from a well-studied model insect species and will facilitate further biochemical and mechanistic experimental studies of many biological systems in insects.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9207282</journal-id><journal-id journal-id-type="pubmed-jr-id">2409</journal-id><journal-id journal-id-type="nlm-ta">Insect Biochem Mol Biol</journal-id><journal-id journal-id-type="iso-abbrev">Insect Biochem. Mol. Biol.</journal-id><journal-title-group><journal-title>Insect biochemistry and molecular biology</journal-title></journal-title-group><issn pub-type="ppub">0965-1748</issn><issn pub-type="epub">1879-0240</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27522922</article-id><article-id pub-id-type="pmc">5010457</article-id><article-id pub-id-type="doi">10.1016/j.ibmb.2016.07.005</article-id><article-id pub-id-type="manuscript">NIHMS810310</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, <italic>Manduca sexta</italic></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kanost</surname><given-names>Michael R.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="author-notes" 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Lorena</given-names></name><xref ref-type="aff" rid="A18">r</xref></contrib><contrib contrib-type="author"><name><surname>Rozas</surname><given-names>Julio</given-names></name><xref ref-type="aff" rid="A16">p</xref></contrib><contrib contrib-type="author"><name><surname>Schwartz</surname><given-names>Lawrence M.</given-names></name><xref ref-type="aff" rid="A51">ay</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Wendy</given-names></name><xref ref-type="aff" rid="A52">az</xref></contrib><contrib contrib-type="author"><name><surname>Southgate</surname><given-names>Agnes</given-names></name><xref ref-type="aff" rid="A53">ba</xref></contrib><contrib contrib-type="author"><name><surname>Vilcinskas</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="A54">bb</xref></contrib><contrib contrib-type="author"><name><surname>Vogt</surname><given-names>Richard</given-names></name><xref ref-type="aff" rid="A55">bc</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Ping</given-names></name><xref ref-type="aff" rid="A37">ak</xref></contrib><contrib contrib-type="author"><name><surname>Werren</surname><given-names>John</given-names></name><xref ref-type="aff" rid="A35">ai</xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>Xiao-Qiang</given-names></name><xref ref-type="aff" rid="A56">bd</xref></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Jing-Jiang</given-names></name><xref ref-type="aff" rid="A57">be</xref></contrib><contrib contrib-type="author"><name><surname>Brown</surname><given-names>Susan J.</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Scherer</surname><given-names>Steven E.</given-names></name><xref ref-type="aff" rid="A10">j</xref></contrib><contrib contrib-type="author"><name><surname>Richards</surname><given-names>Stephen</given-names></name><xref ref-type="aff" rid="A10">j</xref></contrib><contrib contrib-type="author"><name><surname>Blissard</surname><given-names>Gary W.</given-names></name><xref ref-type="author-notes" rid="FN1">1</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66506, USA</aff><aff id="A2"><label>b</label>Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK, 74078, USA</aff><aff id="A3"><label>c</label>Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK, 74078, USA</aff><aff id="A4"><label>d</label>Boyce Thompson Institute at Cornell University, Tower Road Ithaca, NY, 14853, USA</aff><aff id="A5"><label>e</label>KSU Bioinformatics Center, Division of Biology, Kansas State University, Manhattan, KS, 66506, USA</aff><aff id="A6"><label>f</label>Biological Sciences Department, University of Rhode Island, Kingston, RI, 02881, USA</aff><aff id="A7"><label>g</label>Max Planck Institute for Chemical Ecology, Department of Evolutionary Neuroethology, Hans-Knoell-Strasse, 8, D-07745, Jena, Germany</aff><aff id="A8"><label>h</label>Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany</aff><aff id="A9"><label>i</label>Hawkesbury Institute for the Environment, Western Sydney University, Richmond, NSW, 2753, Australia</aff><aff id="A10"><label>j</label>Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA</aff><aff id="A11"><label>k</label>Department of Ecology and Evolutionary Biology, Univ. Kansas, Lawrence, KS, 66045, USA</aff><aff id="A12"><label>l</label>Department of Genetic Medicine and Development, University of Geneva Medical School, rue Michel-Servet 1, 1211, Geneva, Switzerland</aff><aff id="A13"><label>m</label>Swiss Institute of Bioinformatics, rue Michel-Servet 1, 1211, Geneva, Switzerland</aff><aff id="A14"><label>n</label>Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA, 02139, USA</aff><aff id="A15"><label>o</label>The Broad Institute of MIT and Harvard, Cambridge, 415 Main Street, MA, 02142, USA</aff><aff id="A16"><label>p</label>Department de Genètica and Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona, Spain</aff><aff id="A17"><label>q</label>Department of Entomology, China Agricultural University, Beijing, China</aff><aff id="A18"><label>r</label>Division of Biology, Kansas State University, Manhattan, KS, 66506, USA</aff><aff id="A19"><label>s</label>Institut de Recherche sur la Biologie de l’Insecte, UMR CNRS 7261, UFR Sciences et Techniques, Université François-Rabelais, Tours, France</aff><aff id="A20"><label>t</label>CSIRO Land and Water, Clunies Ross St, Acton, ACT, 2601, Australia</aff><aff id="A21"><label>u</label>Department of Zoology, South Parks Road, Oxford, UK</aff><aff id="A22"><label>v</label>Centre of Systems Biology, Biomedical Research Foundation, Academy of Athens, Athens, Greece</aff><aff id="A23"><label>w</label>CSIRO Health and Biosecurity, Clunies Ross St, Acton, ACT, 2601, Australia</aff><aff id="A24"><label>x</label>Center for Functional and Comparative Insect Genomics, Department of Biology, University of Copenhagen, Universitetsparken 15, DK-21oo, Copenhagen, Denmark</aff><aff id="A25"><label>y</label>Department of Biology, Barnard College, Columbia University, 3009 Broadway, New York, NY, 10027, USA</aff><aff id="A26"><label>z</label>Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing, 400715, China</aff><aff id="A27"><label>aa</label>Department of Biology, Reed College, Portland, OR, 97202, USA</aff><aff id="A28"><label>ab</label>Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Bioresources Project Group, Winchesterstrasse 2, 35394, Gießen, Germany</aff><aff id="A29"><label>ac</label>College of Chemistry, Chemical Engineering, and Biotechnology, Donghua University, Shanghai, 201620, China</aff><aff id="A30"><label>ad</label>College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, China</aff><aff id="A31"><label>ae</label>McDermott Center for Human Growth and Development, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA</aff><aff id="A32"><label>af</label>Department of Biological Sciences, University of Southern Maine, Portland, ME, 04104, USA</aff><aff id="A33"><label>ag</label>Department of Ecology and Evolutionary Biology, University of California, Irvine, CA, 92697, USA</aff><aff id="A34"><label>ah</label>School of Plant Protection, Anhui Agricultural University, Hefei, Anhui, China</aff><aff id="A35"><label>ai</label>Department of Biology, University of Rochester, Rochester, NY, 14627, USA</aff><aff id="A36"><label>aj</label>Department of Marine and Environmental Sciences, Northeastern University, Boston, MA, 02115, USA</aff><aff id="A37"><label>ak</label>Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY, 14456, USA</aff><aff id="A38"><label>al</label>State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China</aff><aff id="A39"><label>am</label>Institut fuer Biologie, Universitaet Luebeck, D-23538, Luebeck, Germany</aff><aff id="A40"><label>an</label>Neuroscience Program, Hamilton College, Clinton, NY, 13323, USA</aff><aff id="A41"><label>ao</label>Institute of Zoology, University of Hamburg, Germany</aff><aff id="A42"><label>ap</label>Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium</aff><aff id="A43"><label>aq</label>Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Athens, Greece</aff><aff id="A44"><label>ar</label>Department of Entomology, University of Wisconsin, Madison, USA</aff><aff id="A45"><label>as</label>Biology Department and Neuroscience Program, Hamilton College, Clinton, NY, 13323, USA</aff><aff id="A46"><label>at</label>Dept. Entomology, North Carolina State Univ., Raleigh, NC, 27695, USA</aff><aff id="A47"><label>au</label>University of Siegen, School of Natural Sciences and Engineering, Institute of Biology – Molecular Biology, Adolf-Reichwein-Strasse. 2, AR-C3010, 57076 Siegen, Germany</aff><aff id="A48"><label>av</label>Department of Integrative Biosciences, School of Dentistry, BRB421, L595, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA</aff><aff id="A49"><label>aw</label>Department of Genetics, University of Cambridge, Downing St, Cambridge, CB2 3EH, UK</aff><aff id="A50"><label>ax</label>Department of Entomology, Kansas State University, Manhattan, KS, 66506, USA</aff><aff id="A51"><label>ay</label>Department of Biology, University of Massachusetts, Amherst, MA, 01003, USA</aff><aff id="A52"><label>az</label>Department of Biology, Northeastern University, Boston, MA, 02115, USA</aff><aff id="A53"><label>ba</label>Department of Biology, College of Charleston, Charleston, SC, 29424, USA</aff><aff id="A54"><label>bb</label>Institute for Insect Biotechnology, Justus-Liebig-University, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany</aff><aff id="A55"><label>bc</label>Department of Biological Sciences, University of South Carolina, Columbia, SC, 29205, USA</aff><aff id="A56"><label>bd</label>University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO, 64110, USA</aff><aff id="A57"><label>be</label>Department of Biological Chemistry and Crop Protection, Rothamsted Research, Harpenden, Herts, AL5 2JQ, UK</aff><author-notes><corresp id="cor1"><label>*</label>Corresponding author. <email>Kanost@ksu.edu</email> (M.R. Kanost)</corresp><fn id="FN1"><label>1</label><p id="P1">Co-senior authors.</p></fn><fn id="FN2"><label>†</label><p id="P2">Deceased.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>20</day><month>8</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>12</day><month>8</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>9</month><year>2017</year></pub-date><volume>76</volume><fpage>118</fpage><lpage>147</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.ibmb.2016.07.005</pmc-comment>
<abstract><p id="P3"><italic>Manduca sexta</italic>, known as the tobacco hornworm or Carolina sphinx moth, is a lepidopteran insect that is used extensively as a model system for research in insect biochemistry, physiology, neurobiology, development, and immunity. One important benefit of this species as an experimental model is its extremely large size, reaching more than 10 g in the larval stage. <italic>M. sexta</italic> larvae feed on solanaceous plants and thus must tolerate a substantial challenge from plant allelochemicals, including nicotine. We report the sequence and annotation of the <italic>M. sexta</italic> genome, and a survey of gene expression in various tissues and developmental stages. The Msex_1.0 genome assembly resulted in a total genome size of 419.4 Mbp. Repetitive sequences accounted for 25.8% of the assembled genome. The official gene set is comprised of 15,451 protein-coding genes, of which 2498 were manually curated. Extensive RNA-seq data from many tissues and developmental stages were used to improve gene models and for insights into gene expression patterns. Genome wide synteny analysis indicated a high level of macrosynteny in the Lepidoptera. Annotation and analyses were carried out for gene families involved in a wide spectrum of biological processes, including apoptosis, vacuole sorting, growth and development, structures of exoskeleton, egg shells, and muscle, vision, chemosensation, ion channels, signal transduction, neuropeptide signaling, neurotransmitter synthesis and transport, nicotine tolerance, lipid metabolism, and immunity. This genome sequence, annotation, and analysis provide an important new resource from a well-studied model insect species and will facilitate further biochemical and mechanistic experimental studies of many biological systems in insects.</p></abstract><kwd-group><kwd>Lepidoptera</kwd><kwd>Insect</kwd><kwd>Tobacco hornworm</kwd><kwd>Synteny</kwd><kwd>Moth</kwd><kwd>Insect biochemistry</kwd><kwd>Innate immunity</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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