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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The OncoArray Consortium: a Network for Understanding the Genetic Architecture of Common Cancers</title><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name><affiliation><nlm:aff id="A1">Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover NH</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation><nlm:aff id="A3">Department of Biostatistics, St. Jude’s Hospital, Memphis, TN</nlm:aff></affiliation></author><author><name sortKey="Byun, Jinyoung" sort="Byun, Jinyoung" uniqKey="Byun J" first="Jinyoung" last="Byun">Jinyoung Byun</name><affiliation><nlm:aff id="A1">Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover NH</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation><nlm:aff id="A4">Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A." last="Gayther">Simon A. Gayther</name><affiliation><nlm:aff id="A5">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation><nlm:aff id="A6">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A7">Department of Epidemiology, Program in Molecular and Genetic Epidemiology Harvard School of Public Health, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name><affiliation><nlm:aff id="A8">Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL</nlm:aff></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><affiliation><nlm:aff id="A5">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Fachal, Laura" sort="Fachal, Laura" uniqKey="Fachal L" first="Laura" last="Fachal">Laura Fachal</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Doheny, Kimberly" sort="Doheny, Kimberly" uniqKey="Doheny K" first="Kimberly" last="Doheny">Kimberly Doheny</name><affiliation><nlm:aff id="A9">Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD</nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation><nlm:aff id="A10">Molecular Cancer Epidemiology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD</nlm:aff></affiliation></author><author><name sortKey="Li, Yafang" sort="Li, Yafang" uniqKey="Li Y" first="Yafang" last="Li">Yafang Li</name><affiliation><nlm:aff id="A1">Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover NH</nlm:aff></affiliation></author><author><name sortKey="Xiao, Xiangjun" sort="Xiao, Xiangjun" uniqKey="Xiao X" first="Xiangjun" last="Xiao">Xiangjun Xiao</name><affiliation><nlm:aff id="A1">Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover NH</nlm:aff></affiliation></author><author><name sortKey="Romm, Jane" sort="Romm, Jane" uniqKey="Romm J" first="Jane" last="Romm">Jane Romm</name><affiliation><nlm:aff id="A9">Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD</nlm:aff></affiliation></author><author><name sortKey="Pugh, Elizabeth" sort="Pugh, Elizabeth" uniqKey="Pugh E" first="Elizabeth" last="Pugh">Elizabeth Pugh</name><affiliation><nlm:aff id="A9">Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD</nlm:aff></affiliation></author><author><name sortKey="Coetzee, Gerhard A" sort="Coetzee, Gerhard A" uniqKey="Coetzee G" first="Gerhard A." last="Coetzee">Gerhard A. Coetzee</name><affiliation><nlm:aff id="A11">Professor Van Andel Research Institute, University of Southern California, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Hazelett, Dennis J" sort="Hazelett, Dennis J" uniqKey="Hazelett D" first="Dennis J." last="Hazelett">Dennis J. Hazelett</name><affiliation><nlm:aff id="A12">Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A13">Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark</nlm:aff></affiliation></author><author><name sortKey="Caga Anan, Charlisse" sort="Caga Anan, Charlisse" uniqKey="Caga Anan C" first="Charlisse" last="Caga-Anan">Charlisse Caga-Anan</name><affiliation><nlm:aff id="A14">Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A5">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Kamal, Ahsan" sort="Kamal, Ahsan" uniqKey="Kamal A" first="Ahsan" last="Kamal">Ahsan Kamal</name><affiliation><nlm:aff id="A1">Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover NH</nlm:aff></affiliation></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Tessier, Daniel" sort="Tessier, Daniel" uniqKey="Tessier D" first="Daniel" last="Tessier">Daniel Tessier</name><affiliation><nlm:aff id="A15">Génome Québec Innovation Centre, Montreal, Canada and McGill University, Montreal, Canada</nlm:aff></affiliation></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><affiliation><nlm:aff id="A15">Génome Québec Innovation Centre, Montreal, Canada and McGill University, Montreal, Canada</nlm:aff></affiliation></author><author><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="François" last="Bacot">François Bacot</name><affiliation><nlm:aff id="A15">Génome Québec Innovation Centre, Montreal, Canada and McGill University, Montreal, Canada</nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, David J" sort="Van Den Berg, David J" uniqKey="Van Den Berg D" first="David J." last="Van Den Berg">David J. Van Den Berg</name><affiliation><nlm:aff id="A6">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Nelson, Stefanie" sort="Nelson, Stefanie" uniqKey="Nelson S" first="Stefanie" last="Nelson">Stefanie Nelson</name><affiliation><nlm:aff id="A14">Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Demetriades, Stephen" sort="Demetriades, Stephen" uniqKey="Demetriades S" first="Stephen" last="Demetriades">Stephen Demetriades</name><affiliation><nlm:aff id="A16">University Health Network-The Princess Margaret Cancer Centre, Toronto, CA</nlm:aff></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><affiliation><nlm:aff id="A17">Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT 84112</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A18">Mayo Clinic, 200 First Street SW, Rochester, MN</nlm:aff></affiliation></author><author><name sortKey="Forman, Judith L" sort="Forman, Judith L" uniqKey="Forman J" first="Judith L." last="Forman">Judith L. Forman</name><affiliation><nlm:aff id="A1">Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover NH</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A19">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, 3010, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, 3004, Australia</nlm:aff></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V." last="Conti">David V. Conti</name><affiliation><nlm:aff id="A21">Division of Biostatistics, Department of Preventive Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name><affiliation><nlm:aff id="A22">Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><affiliation><nlm:aff id="A23">University of Salzburg and Cancer Cluster Salzburg, Austria</nlm:aff></affiliation></author><author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name><affiliation><nlm:aff id="A24">Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Bruske, Irene" sort="Bruske, Irene" uniqKey="Bruske I" first="Irene" last="Brüske">Irene Brüske</name><affiliation><nlm:aff id="A25">Helmholtz Zentrum München, Institut für Epidemiologie I, Neuherberg, Oberschleissheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Hicks, Belynda D" sort="Hicks, Belynda D" uniqKey="Hicks B" first="Belynda D." last="Hicks">Belynda D. Hicks</name><affiliation><nlm:aff id="A26">Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD</nlm:aff></affiliation></author><author><name sortKey="Ling, Hua" sort="Ling, Hua" uniqKey="Ling H" first="Hua" last="Ling">Hua Ling</name><affiliation><nlm:aff id="A9">Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD</nlm:aff></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation><nlm:aff id="A19">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, 3010, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, 3004, Australia</nlm:aff></affiliation></author><author><name sortKey="Lee, Andrew" sort="Lee, Andrew" uniqKey="Lee A" first="Andrew" last="Lee">Andrew Lee</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B." last="Kuchenbaecker">Karoline B. Kuchenbaecker</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="A27">Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Manz, Judith" sort="Manz, Judith" uniqKey="Manz J" first="Judith" last="Manz">Judith Manz</name><affiliation><nlm:aff id="A24">Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Cunningham, Julie M" sort="Cunningham, Julie M" uniqKey="Cunningham J" first="Julie M." last="Cunningham">Julie M. Cunningham</name><affiliation><nlm:aff id="A18">Mayo Clinic, 200 First Street SW, Rochester, MN</nlm:aff></affiliation></author><author><name sortKey="Butterbach, Katja" sort="Butterbach, Katja" uniqKey="Butterbach K" first="Katja" last="Butterbach">Katja Butterbach</name><affiliation><nlm:aff id="A28">Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation><nlm:aff id="A29">Institute of Cancer Research, London, England</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A7">Department of Epidemiology, Program in Molecular and Genetic Epidemiology Harvard School of Public Health, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M." last="Fitzgerald">Liesel M. Fitzgerald</name><affiliation><nlm:aff id="A19">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, 3010, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, 3004, Australia</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><affiliation><nlm:aff id="A7">Department of Epidemiology, Program in Molecular and Genetic Epidemiology Harvard School of Public Health, Boston, MA</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Epidemiology, University of Washington, 1959 NE Pacific Street, Health Sciences Bldg, F-247B, Box 357236, Seattle, WA 98195</nlm:aff></affiliation></author><author><name sortKey="Adams, Marcia" sort="Adams, Marcia" uniqKey="Adams M" first="Marcia" last="Adams">Marcia Adams</name><affiliation><nlm:aff id="A9">Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD</nlm:aff></affiliation></author><author><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D." last="Mckay">James D. Mckay</name><affiliation><nlm:aff id="A31">International Agency for Research on Cancer, World Health Organization,, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M." last="Phelan">Catherine M. Phelan</name><affiliation><nlm:aff id="A8">Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL</nlm:aff></affiliation></author><author><name sortKey="Benlloch, Sara" sort="Benlloch, Sara" uniqKey="Benlloch S" first="Sara" last="Benlloch">Sara Benlloch</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Kelemen, Linda E" sort="Kelemen, Linda E" uniqKey="Kelemen L" first="Linda E." last="Kelemen">Linda E. Kelemen</name><affiliation><nlm:aff id="A32">Department of Public Health Sciences. Medical University of South Carolina, Charleston, SC</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="A31">International Agency for Research on Cancer, World Health Organization,, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Riggan, Marjorie" sort="Riggan, Marjorie" uniqKey="Riggan M" first="Marjorie" last="Riggan">Marjorie Riggan</name><affiliation><nlm:aff id="A33">Department of Gynecology, Duke University Medical Center, Durham, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="O Ara, Tracy A" sort="O Ara, Tracy A" uniqKey="O Ara T" first="Tracy A." last="O Ara">Tracy A. O Ara</name><affiliation><nlm:aff id="A34">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Shen, Hongbin" sort="Shen, Hongbin" uniqKey="Shen H" first="Hongbin" last="Shen">Hongbin Shen</name><affiliation><nlm:aff id="A35">Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, School of Public Health, Nanjing Medical University, Nanjing, People’s Republic of China</nlm:aff></affiliation></author><author><name sortKey="Shi, Yongyong" sort="Shi, Yongyong" uniqKey="Shi Y" first="Yongyong" last="Shi">Yongyong Shi</name><affiliation><nlm:aff id="A36">Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, People’s Republic of China</nlm:aff></affiliation></author><author><name sortKey="Thompson, Deborah J" sort="Thompson, Deborah J" uniqKey="Thompson D" first="Deborah J." last="Thompson">Deborah J. Thompson</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Goodman, Marc T" sort="Goodman, Marc T" uniqKey="Goodman M" first="Marc T." last="Goodman">Marc T. Goodman</name><affiliation><nlm:aff id="A12">Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="A37">Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark</nlm:aff></affiliation></author><author><name sortKey="Berchuck, Andrew" sort="Berchuck, Andrew" uniqKey="Berchuck A" first="Andrew" last="Berchuck">Andrew Berchuck</name><affiliation><nlm:aff id="A33">Department of Gynecology, Duke University Medical Center, Durham, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Laboissiere, Sylvie" sort="Laboissiere, Sylvie" uniqKey="Laboissiere S" first="Sylvie" last="Laboissiere">Sylvie Laboissiere</name><affiliation><nlm:aff id="A15">Génome Québec Innovation Centre, Montreal, Canada and McGill University, Montreal, Canada</nlm:aff></affiliation></author><author><name sortKey="Schmit, Stephanie L" sort="Schmit, Stephanie L" uniqKey="Schmit S" first="Stephanie L." last="Schmit">Stephanie L. Schmit</name><affiliation><nlm:aff id="A8">Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center, Tampa, FL</nlm:aff></affiliation></author><author><name sortKey="Shelford, Tameka" sort="Shelford, Tameka" uniqKey="Shelford T" first="Tameka" last="Shelford">Tameka Shelford</name><affiliation><nlm:aff id="A9">Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD</nlm:aff></affiliation></author><author><name sortKey="Edlund, Christopher K" sort="Edlund, Christopher K" uniqKey="Edlund C" first="Christopher K." last="Edlund">Christopher K. Edlund</name><affiliation><nlm:aff id="A6">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Taylor, Jack A" sort="Taylor, Jack A" uniqKey="Taylor J" first="Jack A." last="Taylor">Jack A. Taylor</name><affiliation><nlm:aff id="A39">Molecular and Genetic Epidemiology Group, National Institute for Environmental Health Sciences, Research Triangle Park, NC</nlm:aff></affiliation></author><author><name sortKey="Field, John K" sort="Field, John K" uniqKey="Field J" first="John K." last="Field">John K. Field</name><affiliation><nlm:aff id="A40">Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Park, Sue K" sort="Park, Sue K" uniqKey="Park S" first="Sue K." last="Park">Sue K. Park</name><affiliation><nlm:aff id="A41">College of Medicine, Seoul National University, Gwanak-gu, Seoul</nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="A42">Clinical Genetics Service, Memorial Hospital; Cancer Biology and Genetics Program, Sloan Kettering Institute; Department of Medicine, Weill Cornell Medical College, NY, NY</nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="A43">Department of Clinical Genetics, Odense University Hospital, Sonder Boulevard 29, Odense C, Denmark</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita" sort="Schmutzler, Rita" uniqKey="Schmutzler R" first="Rita" last="Schmutzler">Rita Schmutzler</name><affiliation><nlm:aff id="A44">Zentrum Familiärer Brust-und Eierstockkrebs, Universitätsklinikum Köln, Kerpener Str. 34, 50931 Köln</nlm:aff></affiliation></author><author><name sortKey="Ottini, Laura" sort="Ottini, Laura" uniqKey="Ottini L" first="Laura" last="Ottini">Laura Ottini</name><affiliation><nlm:aff id="A45">Department of Molecular Medicine, Sapienza, University of Rome, Viale Regina Elena 324 00161, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J." last="Hung">Rayjean J. Hung</name><affiliation><nlm:aff id="A46">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Marchini, Jonathan" sort="Marchini, Jonathan" uniqKey="Marchini J" first="Jonathan" last="Marchini">Jonathan Marchini</name><affiliation><nlm:aff id="A47">Department of Statistics, Oxford University, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Al Olama, Ali Amin" sort="Al Olama, Ali Amin" uniqKey="Al Olama A" first="Ali Amin" last="Al Olama">Ali Amin Al Olama</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation><nlm:aff id="A48">Public Health Sciences Division, Fred Hutchinson Cancer Research Center Seattle, WA</nlm:aff></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation><nlm:aff id="A29">Institute of Cancer Research, London, England</nlm:aff></affiliation></author><author><name sortKey="Seldin, Michael F" sort="Seldin, Michael F" uniqKey="Seldin M" first="Michael F." last="Seldin">Michael F. Seldin</name><affiliation><nlm:aff id="A49">Department of Biochemistry and Molecular Medicine, University of California at Davis, Davis, CA</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Department of Internal Medicine, University of California at Davis, Davis, CA</nlm:aff></affiliation></author><author><name sortKey="Gillanders, Elizabeth" sort="Gillanders, Elizabeth" uniqKey="Gillanders E" first="Elizabeth" last="Gillanders">Elizabeth Gillanders</name><affiliation><nlm:aff id="A14">Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation><nlm:aff id="A14">Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D" sort="Pharoah, Paul D" uniqKey="Pharoah P" first="Paul D." last="Pharoah">Paul D. Pharoah</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A34">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A51">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A27">Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27697780</idno><idno type="pmc">5224974</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224974</idno><idno type="RBID">PMC:5224974</idno><idno type="doi">10.1158/1055-9965.EPI-16-0106</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002100</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002100</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The OncoArray Consortium: a Network for Understanding the Genetic Architecture of Common Cancers</title><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name><affiliation><nlm:aff id="A1">Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover NH</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation><nlm:aff id="A3">Department of Biostatistics, St. Jude’s Hospital, Memphis, TN</nlm:aff></affiliation></author><author><name sortKey="Byun, Jinyoung" sort="Byun, Jinyoung" uniqKey="Byun J" first="Jinyoung" last="Byun">Jinyoung Byun</name><affiliation><nlm:aff id="A1">Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover NH</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation><nlm:aff id="A4">Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A." last="Gayther">Simon A. Gayther</name><affiliation><nlm:aff id="A5">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation><nlm:aff id="A6">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A7">Department of Epidemiology, Program in Molecular and Genetic Epidemiology Harvard School of Public Health, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name><affiliation><nlm:aff id="A8">Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL</nlm:aff></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><affiliation><nlm:aff id="A5">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Fachal, Laura" sort="Fachal, Laura" uniqKey="Fachal L" first="Laura" last="Fachal">Laura Fachal</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Doheny, Kimberly" sort="Doheny, Kimberly" uniqKey="Doheny K" first="Kimberly" last="Doheny">Kimberly Doheny</name><affiliation><nlm:aff id="A9">Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD</nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation><nlm:aff id="A10">Molecular Cancer Epidemiology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD</nlm:aff></affiliation></author><author><name sortKey="Li, Yafang" sort="Li, Yafang" uniqKey="Li Y" first="Yafang" last="Li">Yafang Li</name><affiliation><nlm:aff id="A1">Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover NH</nlm:aff></affiliation></author><author><name sortKey="Xiao, Xiangjun" sort="Xiao, Xiangjun" uniqKey="Xiao X" first="Xiangjun" last="Xiao">Xiangjun Xiao</name><affiliation><nlm:aff id="A1">Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover NH</nlm:aff></affiliation></author><author><name sortKey="Romm, Jane" sort="Romm, Jane" uniqKey="Romm J" first="Jane" last="Romm">Jane Romm</name><affiliation><nlm:aff id="A9">Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD</nlm:aff></affiliation></author><author><name sortKey="Pugh, Elizabeth" sort="Pugh, Elizabeth" uniqKey="Pugh E" first="Elizabeth" last="Pugh">Elizabeth Pugh</name><affiliation><nlm:aff id="A9">Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD</nlm:aff></affiliation></author><author><name sortKey="Coetzee, Gerhard A" sort="Coetzee, Gerhard A" uniqKey="Coetzee G" first="Gerhard A." last="Coetzee">Gerhard A. Coetzee</name><affiliation><nlm:aff id="A11">Professor Van Andel Research Institute, University of Southern California, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Hazelett, Dennis J" sort="Hazelett, Dennis J" uniqKey="Hazelett D" first="Dennis J." last="Hazelett">Dennis J. Hazelett</name><affiliation><nlm:aff id="A12">Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A13">Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark</nlm:aff></affiliation></author><author><name sortKey="Caga Anan, Charlisse" sort="Caga Anan, Charlisse" uniqKey="Caga Anan C" first="Charlisse" last="Caga-Anan">Charlisse Caga-Anan</name><affiliation><nlm:aff id="A14">Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A5">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Kamal, Ahsan" sort="Kamal, Ahsan" uniqKey="Kamal A" first="Ahsan" last="Kamal">Ahsan Kamal</name><affiliation><nlm:aff id="A1">Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover NH</nlm:aff></affiliation></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Tessier, Daniel" sort="Tessier, Daniel" uniqKey="Tessier D" first="Daniel" last="Tessier">Daniel Tessier</name><affiliation><nlm:aff id="A15">Génome Québec Innovation Centre, Montreal, Canada and McGill University, Montreal, Canada</nlm:aff></affiliation></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><affiliation><nlm:aff id="A15">Génome Québec Innovation Centre, Montreal, Canada and McGill University, Montreal, Canada</nlm:aff></affiliation></author><author><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="François" last="Bacot">François Bacot</name><affiliation><nlm:aff id="A15">Génome Québec Innovation Centre, Montreal, Canada and McGill University, Montreal, Canada</nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, David J" sort="Van Den Berg, David J" uniqKey="Van Den Berg D" first="David J." last="Van Den Berg">David J. Van Den Berg</name><affiliation><nlm:aff id="A6">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Nelson, Stefanie" sort="Nelson, Stefanie" uniqKey="Nelson S" first="Stefanie" last="Nelson">Stefanie Nelson</name><affiliation><nlm:aff id="A14">Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Demetriades, Stephen" sort="Demetriades, Stephen" uniqKey="Demetriades S" first="Stephen" last="Demetriades">Stephen Demetriades</name><affiliation><nlm:aff id="A16">University Health Network-The Princess Margaret Cancer Centre, Toronto, CA</nlm:aff></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><affiliation><nlm:aff id="A17">Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT 84112</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A18">Mayo Clinic, 200 First Street SW, Rochester, MN</nlm:aff></affiliation></author><author><name sortKey="Forman, Judith L" sort="Forman, Judith L" uniqKey="Forman J" first="Judith L." last="Forman">Judith L. Forman</name><affiliation><nlm:aff id="A1">Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover NH</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A19">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, 3010, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, 3004, Australia</nlm:aff></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V." last="Conti">David V. Conti</name><affiliation><nlm:aff id="A21">Division of Biostatistics, Department of Preventive Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name><affiliation><nlm:aff id="A22">Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><affiliation><nlm:aff id="A23">University of Salzburg and Cancer Cluster Salzburg, Austria</nlm:aff></affiliation></author><author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name><affiliation><nlm:aff id="A24">Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Bruske, Irene" sort="Bruske, Irene" uniqKey="Bruske I" first="Irene" last="Brüske">Irene Brüske</name><affiliation><nlm:aff id="A25">Helmholtz Zentrum München, Institut für Epidemiologie I, Neuherberg, Oberschleissheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Hicks, Belynda D" sort="Hicks, Belynda D" uniqKey="Hicks B" first="Belynda D." last="Hicks">Belynda D. Hicks</name><affiliation><nlm:aff id="A26">Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD</nlm:aff></affiliation></author><author><name sortKey="Ling, Hua" sort="Ling, Hua" uniqKey="Ling H" first="Hua" last="Ling">Hua Ling</name><affiliation><nlm:aff id="A9">Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD</nlm:aff></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation><nlm:aff id="A19">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, 3010, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, 3004, Australia</nlm:aff></affiliation></author><author><name sortKey="Lee, Andrew" sort="Lee, Andrew" uniqKey="Lee A" first="Andrew" last="Lee">Andrew Lee</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B." last="Kuchenbaecker">Karoline B. Kuchenbaecker</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="A27">Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Manz, Judith" sort="Manz, Judith" uniqKey="Manz J" first="Judith" last="Manz">Judith Manz</name><affiliation><nlm:aff id="A24">Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Cunningham, Julie M" sort="Cunningham, Julie M" uniqKey="Cunningham J" first="Julie M." last="Cunningham">Julie M. Cunningham</name><affiliation><nlm:aff id="A18">Mayo Clinic, 200 First Street SW, Rochester, MN</nlm:aff></affiliation></author><author><name sortKey="Butterbach, Katja" sort="Butterbach, Katja" uniqKey="Butterbach K" first="Katja" last="Butterbach">Katja Butterbach</name><affiliation><nlm:aff id="A28">Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation><nlm:aff id="A29">Institute of Cancer Research, London, England</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A7">Department of Epidemiology, Program in Molecular and Genetic Epidemiology Harvard School of Public Health, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M." last="Fitzgerald">Liesel M. Fitzgerald</name><affiliation><nlm:aff id="A19">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, 3010, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, 3004, Australia</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><affiliation><nlm:aff id="A7">Department of Epidemiology, Program in Molecular and Genetic Epidemiology Harvard School of Public Health, Boston, MA</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Epidemiology, University of Washington, 1959 NE Pacific Street, Health Sciences Bldg, F-247B, Box 357236, Seattle, WA 98195</nlm:aff></affiliation></author><author><name sortKey="Adams, Marcia" sort="Adams, Marcia" uniqKey="Adams M" first="Marcia" last="Adams">Marcia Adams</name><affiliation><nlm:aff id="A9">Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD</nlm:aff></affiliation></author><author><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D." last="Mckay">James D. Mckay</name><affiliation><nlm:aff id="A31">International Agency for Research on Cancer, World Health Organization,, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M." last="Phelan">Catherine M. Phelan</name><affiliation><nlm:aff id="A8">Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL</nlm:aff></affiliation></author><author><name sortKey="Benlloch, Sara" sort="Benlloch, Sara" uniqKey="Benlloch S" first="Sara" last="Benlloch">Sara Benlloch</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Kelemen, Linda E" sort="Kelemen, Linda E" uniqKey="Kelemen L" first="Linda E." last="Kelemen">Linda E. Kelemen</name><affiliation><nlm:aff id="A32">Department of Public Health Sciences. Medical University of South Carolina, Charleston, SC</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="A31">International Agency for Research on Cancer, World Health Organization,, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Riggan, Marjorie" sort="Riggan, Marjorie" uniqKey="Riggan M" first="Marjorie" last="Riggan">Marjorie Riggan</name><affiliation><nlm:aff id="A33">Department of Gynecology, Duke University Medical Center, Durham, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="O Ara, Tracy A" sort="O Ara, Tracy A" uniqKey="O Ara T" first="Tracy A." last="O Ara">Tracy A. O Ara</name><affiliation><nlm:aff id="A34">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Shen, Hongbin" sort="Shen, Hongbin" uniqKey="Shen H" first="Hongbin" last="Shen">Hongbin Shen</name><affiliation><nlm:aff id="A35">Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, School of Public Health, Nanjing Medical University, Nanjing, People’s Republic of China</nlm:aff></affiliation></author><author><name sortKey="Shi, Yongyong" sort="Shi, Yongyong" uniqKey="Shi Y" first="Yongyong" last="Shi">Yongyong Shi</name><affiliation><nlm:aff id="A36">Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, People’s Republic of China</nlm:aff></affiliation></author><author><name sortKey="Thompson, Deborah J" sort="Thompson, Deborah J" uniqKey="Thompson D" first="Deborah J." last="Thompson">Deborah J. Thompson</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Goodman, Marc T" sort="Goodman, Marc T" uniqKey="Goodman M" first="Marc T." last="Goodman">Marc T. Goodman</name><affiliation><nlm:aff id="A12">Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="A37">Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark</nlm:aff></affiliation></author><author><name sortKey="Berchuck, Andrew" sort="Berchuck, Andrew" uniqKey="Berchuck A" first="Andrew" last="Berchuck">Andrew Berchuck</name><affiliation><nlm:aff id="A33">Department of Gynecology, Duke University Medical Center, Durham, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Laboissiere, Sylvie" sort="Laboissiere, Sylvie" uniqKey="Laboissiere S" first="Sylvie" last="Laboissiere">Sylvie Laboissiere</name><affiliation><nlm:aff id="A15">Génome Québec Innovation Centre, Montreal, Canada and McGill University, Montreal, Canada</nlm:aff></affiliation></author><author><name sortKey="Schmit, Stephanie L" sort="Schmit, Stephanie L" uniqKey="Schmit S" first="Stephanie L." last="Schmit">Stephanie L. Schmit</name><affiliation><nlm:aff id="A8">Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center, Tampa, FL</nlm:aff></affiliation></author><author><name sortKey="Shelford, Tameka" sort="Shelford, Tameka" uniqKey="Shelford T" first="Tameka" last="Shelford">Tameka Shelford</name><affiliation><nlm:aff id="A9">Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD</nlm:aff></affiliation></author><author><name sortKey="Edlund, Christopher K" sort="Edlund, Christopher K" uniqKey="Edlund C" first="Christopher K." last="Edlund">Christopher K. Edlund</name><affiliation><nlm:aff id="A6">Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Taylor, Jack A" sort="Taylor, Jack A" uniqKey="Taylor J" first="Jack A." last="Taylor">Jack A. Taylor</name><affiliation><nlm:aff id="A39">Molecular and Genetic Epidemiology Group, National Institute for Environmental Health Sciences, Research Triangle Park, NC</nlm:aff></affiliation></author><author><name sortKey="Field, John K" sort="Field, John K" uniqKey="Field J" first="John K." last="Field">John K. Field</name><affiliation><nlm:aff id="A40">Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Park, Sue K" sort="Park, Sue K" uniqKey="Park S" first="Sue K." last="Park">Sue K. Park</name><affiliation><nlm:aff id="A41">College of Medicine, Seoul National University, Gwanak-gu, Seoul</nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="A42">Clinical Genetics Service, Memorial Hospital; Cancer Biology and Genetics Program, Sloan Kettering Institute; Department of Medicine, Weill Cornell Medical College, NY, NY</nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="A43">Department of Clinical Genetics, Odense University Hospital, Sonder Boulevard 29, Odense C, Denmark</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita" sort="Schmutzler, Rita" uniqKey="Schmutzler R" first="Rita" last="Schmutzler">Rita Schmutzler</name><affiliation><nlm:aff id="A44">Zentrum Familiärer Brust-und Eierstockkrebs, Universitätsklinikum Köln, Kerpener Str. 34, 50931 Köln</nlm:aff></affiliation></author><author><name sortKey="Ottini, Laura" sort="Ottini, Laura" uniqKey="Ottini L" first="Laura" last="Ottini">Laura Ottini</name><affiliation><nlm:aff id="A45">Department of Molecular Medicine, Sapienza, University of Rome, Viale Regina Elena 324 00161, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J." last="Hung">Rayjean J. Hung</name><affiliation><nlm:aff id="A46">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Marchini, Jonathan" sort="Marchini, Jonathan" uniqKey="Marchini J" first="Jonathan" last="Marchini">Jonathan Marchini</name><affiliation><nlm:aff id="A47">Department of Statistics, Oxford University, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Al Olama, Ali Amin" sort="Al Olama, Ali Amin" uniqKey="Al Olama A" first="Ali Amin" last="Al Olama">Ali Amin Al Olama</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation><nlm:aff id="A48">Public Health Sciences Division, Fred Hutchinson Cancer Research Center Seattle, WA</nlm:aff></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation><nlm:aff id="A29">Institute of Cancer Research, London, England</nlm:aff></affiliation></author><author><name sortKey="Seldin, Michael F" sort="Seldin, Michael F" uniqKey="Seldin M" first="Michael F." last="Seldin">Michael F. Seldin</name><affiliation><nlm:aff id="A49">Department of Biochemistry and Molecular Medicine, University of California at Davis, Davis, CA</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Department of Internal Medicine, University of California at Davis, Davis, CA</nlm:aff></affiliation></author><author><name sortKey="Gillanders, Elizabeth" sort="Gillanders, Elizabeth" uniqKey="Gillanders E" first="Elizabeth" last="Gillanders">Elizabeth Gillanders</name><affiliation><nlm:aff id="A14">Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation><nlm:aff id="A14">Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D" sort="Pharoah, Paul D" uniqKey="Pharoah P" first="Paul D." last="Pharoah">Paul D. Pharoah</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A34">Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A51">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A27">Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the OncoArray. The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping of known susceptibility regions, rare variants from sequencing experiments, pharmacogenetic markers and cancer related traits.</p></sec><sec id="S2"><title>Methods</title><p id="P2">The OncoArray can be genotyped using a novel technology developed by Illumina to facilitate efficient genotyping. The consortium developed standard approaches for selecting SNPs for study, for quality control of markers and for ancestry analysis. The array was genotyped at selected sites and with prespecified replicate samples to permit evaluation of genotyping accuracy among centers and by ethnic background.</p></sec><sec id="S3"><title>Results</title><p id="P3">The OncoArray consortium genotyped 447,705 samples. A total of 494,763 SNPs passed quality control steps with a sample success rate of 97% of the samples. Participating sites performed ancestry analysis using a common set of markers and a scoring algorithm based on principal components analysis.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Results from these analyses will enable researchers to identify new susceptibility loci, perform fine mapping of new or known loci associated with either single or multiple cancers, assess the degree of overlap in cancer causation and pleiotropic effects of loci that have been identified for disease-specific risk, and jointly model genetic, environmental and lifestyle related exposures.</p></sec><sec id="S5"><title>Impact</title><p id="P5">Ongoing analyses will shed light on etiology and risk assessment for many types of cancer.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9200608</journal-id><journal-id journal-id-type="pubmed-jr-id">2299</journal-id><journal-id journal-id-type="nlm-ta">Cancer Epidemiol Biomarkers Prev</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Epidemiol. Biomarkers Prev.</journal-id><journal-title-group><journal-title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</journal-title></journal-title-group><issn pub-type="ppub">1055-9965</issn><issn pub-type="epub">1538-7755</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27697780</article-id><article-id pub-id-type="pmc">5224974</article-id><article-id pub-id-type="doi">10.1158/1055-9965.EPI-16-0106</article-id><article-id pub-id-type="manuscript">NIHMS818487</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The OncoArray Consortium: a Network for Understanding the Genetic Architecture of Common Cancers</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Amos</surname><given-names>Christopher 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contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover NH</aff><aff id="A2"><label>2</label>Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom</aff><aff id="A3"><label>3</label>Department of Biostatistics, St. Jude’s Hospital, Memphis, TN</aff><aff id="A4"><label>4</label>Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH</aff><aff id="A5"><label>5</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA</aff><aff id="A6"><label>6</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA</aff><aff id="A7"><label>7</label>Department of Epidemiology, Program in Molecular and Genetic Epidemiology Harvard School of Public Health, Boston, MA</aff><aff id="A8"><label>8</label>Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL</aff><aff id="A9"><label>9</label>Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD</aff><aff id="A10"><label>10</label>Molecular Cancer Epidemiology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD</aff><aff id="A11"><label>11</label>Professor Van Andel Research Institute, University of Southern California, Los Angeles, CA</aff><aff id="A12"><label>12</label>Cedars-Sinai Medical Center, Los Angeles, CA</aff><aff id="A13"><label>13</label>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark</aff><aff id="A14"><label>14</label>Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD</aff><aff id="A15"><label>15</label>Génome Québec Innovation Centre, Montreal, Canada and McGill University, Montreal, Canada</aff><aff id="A16"><label>16</label>University Health Network-The Princess Margaret Cancer Centre, Toronto, CA</aff><aff id="A17"><label>17</label>Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT 84112</aff><aff id="A18"><label>18</label>Mayo Clinic, 200 First Street SW, Rochester, MN</aff><aff id="A19"><label>19</label>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, 3010, Australia</aff><aff id="A20"><label>20</label>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, 3004, Australia</aff><aff id="A21"><label>21</label>Division of Biostatistics, Department of Preventive Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA</aff><aff id="A22"><label>22</label>Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Germany</aff><aff id="A23"><label>23</label>University of Salzburg and Cancer Cluster Salzburg, Austria</aff><aff id="A24"><label>24</label>Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A25"><label>25</label>Helmholtz Zentrum München, Institut für Epidemiologie I, Neuherberg, Oberschleissheim, Germany</aff><aff id="A26"><label>26</label>Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD</aff><aff id="A27"><label>27</label>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Canada</aff><aff id="A28"><label>28</label>Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A29"><label>29</label>Institute of Cancer Research, London, England</aff><aff id="A30"><label>30</label>Department of Epidemiology, University of Washington, 1959 NE Pacific Street, Health Sciences Bldg, F-247B, Box 357236, Seattle, WA 98195</aff><aff id="A31"><label>31</label>International Agency for Research on Cancer, World Health Organization,, Lyon, France</aff><aff id="A32"><label>32</label>Department of Public Health Sciences. Medical University of South Carolina, Charleston, SC</aff><aff id="A33"><label>33</label>Department of Gynecology, Duke University Medical Center, Durham, North Carolina, USA</aff><aff id="A34"><label>34</label>Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</aff><aff id="A35"><label>35</label>Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, School of Public Health, Nanjing Medical University, Nanjing, People’s Republic of China</aff><aff id="A36"><label>36</label>Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, People’s Republic of China</aff><aff id="A37"><label>37</label>Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark</aff><aff id="A38"><label>38</label>Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center, Tampa, FL</aff><aff id="A39"><label>39</label>Molecular and Genetic Epidemiology Group, National Institute for Environmental Health Sciences, Research Triangle Park, NC</aff><aff id="A40"><label>40</label>Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom</aff><aff id="A41"><label>41</label>College of Medicine, Seoul National University, Gwanak-gu, Seoul</aff><aff id="A42"><label>42</label>Clinical Genetics Service, Memorial Hospital; Cancer Biology and Genetics Program, Sloan Kettering Institute; Department of Medicine, Weill Cornell Medical College, NY, NY</aff><aff id="A43"><label>43</label>Department of Clinical Genetics, Odense University Hospital, Sonder Boulevard 29, Odense C, Denmark</aff><aff id="A44"><label>44</label>Zentrum Familiärer Brust-und Eierstockkrebs, Universitätsklinikum Köln, Kerpener Str. 34, 50931 Köln</aff><aff id="A45"><label>45</label>Department of Molecular Medicine, Sapienza, University of Rome, Viale Regina Elena 324 00161, Rome, Italy</aff><aff id="A46"><label>46</label>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Canada</aff><aff id="A47"><label>47</label>Department of Statistics, Oxford University, Oxford, UK</aff><aff id="A48"><label>48</label>Public Health Sciences Division, Fred Hutchinson Cancer Research Center Seattle, WA</aff><aff id="A49"><label>49</label>Department of Biochemistry and Molecular Medicine, University of California at Davis, Davis, CA</aff><aff id="A50"><label>50</label>Department of Internal Medicine, University of California at Davis, Davis, CA</aff><aff id="A51"><label>51</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</aff><author-notes><corresp id="FN1">Communicating Author: Christopher I. Amos, Ph.D., Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, 1 Medical Center Drive, Lebanon, NH 03766, Phone: 603-650-1972, FAX: 603-650-1966</corresp><fn id="FN2"><p>C.I. Amos, D. J. Hunter, F.R. Schumacher, S. B. Gruber, T.A. Sellers on behalf of the GAME-ON Consortium, A. B. Spurdle on behalf of the ECAC Consortium, H. Bickeböller on behalf of the GLC Consortium, D.F. Easton on behalf of the BCAC Consortium, G. Chevenix-Trench on behalf of the CIMBA consortium, J. Simard on behalf of the PERSPECTIVE consortium, P.D. Pharoah on behalf of the OCAC consortium and R. A. Eeles on behalf of the PRACTICAL consortia. Other contributors provided input independent of these consortia.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>26</day><month>10</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>03</day><month>10</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>7</month><year>2017</year></pub-date><volume>26</volume><issue>1</issue><fpage>126</fpage><lpage>135</lpage><pmc-comment>elocation-id from pubmed: 10.1158/1055-9965.EPI-16-0106</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the OncoArray. The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping of known susceptibility regions, rare variants from sequencing experiments, pharmacogenetic markers and cancer related traits.</p></sec><sec id="S2"><title>Methods</title><p id="P2">The OncoArray can be genotyped using a novel technology developed by Illumina to facilitate efficient genotyping. The consortium developed standard approaches for selecting SNPs for study, for quality control of markers and for ancestry analysis. The array was genotyped at selected sites and with prespecified replicate samples to permit evaluation of genotyping accuracy among centers and by ethnic background.</p></sec><sec id="S3"><title>Results</title><p id="P3">The OncoArray consortium genotyped 447,705 samples. A total of 494,763 SNPs passed quality control steps with a sample success rate of 97% of the samples. Participating sites performed ancestry analysis using a common set of markers and a scoring algorithm based on principal components analysis.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Results from these analyses will enable researchers to identify new susceptibility loci, perform fine mapping of new or known loci associated with either single or multiple cancers, assess the degree of overlap in cancer causation and pleiotropic effects of loci that have been identified for disease-specific risk, and jointly model genetic, environmental and lifestyle related exposures.</p></sec><sec id="S5"><title>Impact</title><p id="P5">Ongoing analyses will shed light on etiology and risk assessment for many types of cancer.</p></sec></abstract><kwd-group><kwd>Genetic Susceptibility</kwd><kwd>Genetic Epidemiology</kwd><kwd>Ancestry</kwd><kwd>Epistasis</kwd><kwd>Cancer</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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