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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk</title><author><name sortKey="Guo, Xingyi" sort="Guo, Xingyi" uniqKey="Guo X" first="Xingyi" last="Guo">Xingyi Guo</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Zeng, Chenjie" sort="Zeng, Chenjie" uniqKey="Zeng C" first="Chenjie" last="Zeng">Chenjie Zeng</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A4">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A6">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Kar, Siddhartha P" sort="Kar, Siddhartha P" uniqKey="Kar S" first="Siddhartha P." last="Kar">Siddhartha P. Kar</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A7">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Molecular Genetics, University of Toronto, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A9">Department of Epidemiology, University of California Irvine, Irvine, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A10">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A11">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Beeghly Fadiel, Alicia" sort="Beeghly Fadiel, Alicia" uniqKey="Beeghly Fadiel A" first="Alicia" last="Beeghly-Fadiel">Alicia Beeghly-Fadiel</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A12">Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Blot, William" sort="Blot, William" uniqKey="Blot W" first="William" last="Blot">William Blot</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A14">International Epidemiology Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia" sort="Bogdanova, Natalia" uniqKey="Bogdanova N" first="Natalia" last="Bogdanova">Natalia Bogdanova</name><affiliation><nlm:aff id="A15">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A16">Copenhagen General Population Study, Herlev Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A19">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A20">University of Tübingen, Tübingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A21">German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A10">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A21">German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><affiliation><nlm:aff id="A23">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="A24">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="A25">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="A26">Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Molecular Epidemiology Group, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Cai, Hui" sort="Cai, Hui" uniqKey="Cai H" first="Hui" last="Cai">Hui Cai</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Canisius, Sander" sort="Canisius, Sander" uniqKey="Canisius S" first="Sander" last="Canisius">Sander Canisius</name><affiliation><nlm:aff id="A28">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A29">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name><affiliation><nlm:aff id="A30">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A32">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A33">Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="A34">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A35">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="A35">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="A36">Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Droit, Arnaud" sort="Droit, Arnaud" uniqKey="Droit A" first="Arnaud" last="Droit">Arnaud Droit</name><affiliation><nlm:aff id="A38">Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec, Canada</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="A39">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A11">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A40">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A41">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="A42">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation><nlm:aff id="A43">Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation><nlm:aff id="A44">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="A45">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A4">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name><affiliation><nlm:aff id="A46">Department of Surgery, Oulu University Hospital and University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="A47">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A48">University Paris-Sud, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A49">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A50">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation><nlm:aff id="A51">Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Department of Surgery, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="A53">Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A5">Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name><affiliation><nlm:aff id="A54">Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name><affiliation><nlm:aff id="A56">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi, Japan</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A57">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="A41">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation><nlm:aff id="A50">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="A58">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation><nlm:aff id="A59">Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, FI-00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="A60">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, M5S 1A8, Canada</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A62">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A63">Vesalius Research Center, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Marchand, Loic Le" sort="Marchand, Loic Le" uniqKey="Marchand L" first="Loic Le" last="Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="A65">University of Hawaii Cancer Center, Honolulu, HI, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="A35">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="A66">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="A67">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A57">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A62">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A68">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="A69">Department of Oncology - Pathology, Karolinska Institutet, Stockholm SE, Sweden</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="A70">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:aff id="A72">Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona A" sort="Mclean, Catriona A" uniqKey="Mclean C" first="Catriona A." last="Mclean">Catriona A. Mclean</name><affiliation><nlm:aff id="A73">Anatomical Pathology, The Alfred Hospital, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A74">Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="A68">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A75">Institute of Population Health, University of Manchester, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A76">Beckman Research Institute of City of Hope, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A59">Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, FI-00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Nord, Silje" sort="Nord, Silje" uniqKey="Nord S" first="Silje" last="Nord">Silje Nord</name><affiliation><nlm:aff id="A77">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A78">K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="A79">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="A80">Division of Breast Cancer Research, Institute of Cancer Research, London, UK; Cancer Research, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A81">IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Putti, Thomas Choudary" sort="Putti, Thomas Choudary" uniqKey="Putti T" first="Thomas Choudary" last="Putti">Thomas Choudary Putti</name><affiliation><nlm:aff id="A82">Department of Pathology, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A29">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="A83">National Cancer Institute, Bangkok, Thailand</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="A84">Research Oncology, Guy’s Hospital, King's College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A24">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A85">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Center for Molecular Medicine, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="A89">School of Public Health, China Medical University, Taichung, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Shi, Jiajun" sort="Shi, Jiajun" uniqKey="Shi J" first="Jiajun" last="Shi">Jiajun Shi</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Martha J" sort="Shrubsole, Martha J" uniqKey="Shrubsole M" first="Martha J" last="Shrubsole">Martha J. Shrubsole</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A91">Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="A92">Division of Genetics and Epidemiology and Division of Breast Cancer Research, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo Hwang" last="Teo">Soo Hwang Teo</name><affiliation><nlm:aff id="A93">Cancer Research Initiatives Foundation, Subang Jaya, Selangor, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="A94">Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Thienpont, Bernard" sort="Thienpont, Bernard" uniqKey="Thienpont B" first="Bernard" last="Thienpont">Bernard Thienpont</name><affiliation><nlm:aff id="A63">Vesalius Research Center, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda Ewart" sort="Toland, Amanda Ewart" uniqKey="Toland A" first="Amanda Ewart" last="Toland">Amanda Ewart Toland</name><affiliation><nlm:aff id="A95">Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="A96">Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian P M" sort="Tomlinson, Ian P M" uniqKey="Tomlinson I" first="Ian P. M." last="Tomlinson">Ian P. M. Tomlinson</name><affiliation><nlm:aff id="A97">Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="A47">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A48">University Paris-Sud, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name><affiliation><nlm:aff id="A49">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Van Den Ouweland, Ans" sort="Van Den Ouweland, Ans" uniqKey="Van Den Ouweland A" first="Ans" last="Van Den Ouweland">Ans Van Den Ouweland</name><affiliation><nlm:aff id="A98">Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wen, Wanqing" sort="Wen, Wanqing" uniqKey="Wen W" first="Wanqing" last="Wen">Wanqing Wen</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A99">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A100">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Wu, Anna" sort="Wu, Anna" uniqKey="Wu A" first="Anna" last="Wu">Anna Wu</name><affiliation><nlm:aff id="A49">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng Har" last="Yip">Cheng Har Yip</name><affiliation><nlm:aff id="A94">Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="A101">Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Zheng, Ying" sort="Zheng, Ying" uniqKey="Zheng Y" first="Ying" last="Zheng">Ying Zheng</name><affiliation><nlm:aff id="A102">Shanghai Municipal Center for Disease Control and Prevention, Shanghai, PR China</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A35">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. 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Dunning</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26354892</idno><idno type="pmc">4633342</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633342</idno><idno type="RBID">PMC:4633342</idno><idno type="doi">10.1158/1055-9965.EPI-15-0363</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002098</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002098</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk</title><author><name sortKey="Guo, Xingyi" sort="Guo, Xingyi" uniqKey="Guo X" first="Xingyi" last="Guo">Xingyi Guo</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Zeng, Chenjie" sort="Zeng, Chenjie" uniqKey="Zeng C" first="Chenjie" last="Zeng">Chenjie Zeng</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A4">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A6">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Kar, Siddhartha P" sort="Kar, Siddhartha P" uniqKey="Kar S" first="Siddhartha P." last="Kar">Siddhartha P. Kar</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A7">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Molecular Genetics, University of Toronto, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A9">Department of Epidemiology, University of California Irvine, Irvine, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A10">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A11">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Beeghly Fadiel, Alicia" sort="Beeghly Fadiel, Alicia" uniqKey="Beeghly Fadiel A" first="Alicia" last="Beeghly-Fadiel">Alicia Beeghly-Fadiel</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A12">Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Blot, William" sort="Blot, William" uniqKey="Blot W" first="William" last="Blot">William Blot</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A14">International Epidemiology Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia" sort="Bogdanova, Natalia" uniqKey="Bogdanova N" first="Natalia" last="Bogdanova">Natalia Bogdanova</name><affiliation><nlm:aff id="A15">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A16">Copenhagen General Population Study, Herlev Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A19">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A20">University of Tübingen, Tübingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A21">German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A10">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A21">German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><affiliation><nlm:aff id="A23">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="A24">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="A25">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="A26">Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Molecular Epidemiology Group, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Cai, Hui" sort="Cai, Hui" uniqKey="Cai H" first="Hui" last="Cai">Hui Cai</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Canisius, Sander" sort="Canisius, Sander" uniqKey="Canisius S" first="Sander" last="Canisius">Sander Canisius</name><affiliation><nlm:aff id="A28">Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A29">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name><affiliation><nlm:aff id="A30">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A32">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A33">Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="A34">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A35">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="A35">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="A36">Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Droit, Arnaud" sort="Droit, Arnaud" uniqKey="Droit A" first="Arnaud" last="Droit">Arnaud Droit</name><affiliation><nlm:aff id="A38">Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec, Canada</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="A39">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A11">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A40">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A41">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="A42">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation><nlm:aff id="A43">Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation><nlm:aff id="A44">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="A45">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A4">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name><affiliation><nlm:aff id="A46">Department of Surgery, Oulu University Hospital and University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="A47">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A48">University Paris-Sud, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A49">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A50">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation><nlm:aff id="A51">Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Department of Surgery, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="A53">Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A5">Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name><affiliation><nlm:aff id="A54">Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name><affiliation><nlm:aff id="A56">Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi, Japan</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A57">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="A41">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation><nlm:aff id="A50">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="A58">Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation><nlm:aff id="A59">Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, FI-00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="A60">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, M5S 1A8, Canada</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A62">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A63">Vesalius Research Center, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Marchand, Loic Le" sort="Marchand, Loic Le" uniqKey="Marchand L" first="Loic Le" last="Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="A65">University of Hawaii Cancer Center, Honolulu, HI, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="A35">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="A66">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="A67">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A57">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A62">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A68">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="A69">Department of Oncology - Pathology, Karolinska Institutet, Stockholm SE, Sweden</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="A70">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name><affiliation><nlm:aff id="A72">Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona A" sort="Mclean, Catriona A" uniqKey="Mclean C" first="Catriona A." last="Mclean">Catriona A. Mclean</name><affiliation><nlm:aff id="A73">Anatomical Pathology, The Alfred Hospital, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A74">Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="A68">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A75">Institute of Population Health, University of Manchester, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A76">Beckman Research Institute of City of Hope, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A59">Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, FI-00029 HUS, Finland</nlm:aff></affiliation></author><author><name sortKey="Nord, Silje" sort="Nord, Silje" uniqKey="Nord S" first="Silje" last="Nord">Silje Nord</name><affiliation><nlm:aff id="A77">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A78">K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="A79">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="A80">Division of Breast Cancer Research, Institute of Cancer Research, London, UK; Cancer Research, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A81">IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Putti, Thomas Choudary" sort="Putti, Thomas Choudary" uniqKey="Putti T" first="Thomas Choudary" last="Putti">Thomas Choudary Putti</name><affiliation><nlm:aff id="A82">Department of Pathology, National University Health System, Singapore</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A29">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="A83">National Cancer Institute, Bangkok, Thailand</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="A84">Research Oncology, Guy’s Hospital, King's College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A24">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A85">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Center for Molecular Medicine, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="A89">School of Public Health, China Medical University, Taichung, Taiwan</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Shi, Jiajun" sort="Shi, Jiajun" uniqKey="Shi J" first="Jiajun" last="Shi">Jiajun Shi</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Martha J" sort="Shrubsole, Martha J" uniqKey="Shrubsole M" first="Martha J" last="Shrubsole">Martha J. Shrubsole</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A91">Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="A92">Division of Genetics and Epidemiology and Division of Breast Cancer Research, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo Hwang" last="Teo">Soo Hwang Teo</name><affiliation><nlm:aff id="A93">Cancer Research Initiatives Foundation, Subang Jaya, Selangor, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="A94">Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Thienpont, Bernard" sort="Thienpont, Bernard" uniqKey="Thienpont B" first="Bernard" last="Thienpont">Bernard Thienpont</name><affiliation><nlm:aff id="A63">Vesalius Research Center, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda Ewart" sort="Toland, Amanda Ewart" uniqKey="Toland A" first="Amanda Ewart" last="Toland">Amanda Ewart Toland</name><affiliation><nlm:aff id="A95">Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="A96">Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian P M" sort="Tomlinson, Ian P M" uniqKey="Tomlinson I" first="Ian P. M." last="Tomlinson">Ian P. M. Tomlinson</name><affiliation><nlm:aff id="A97">Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="A47">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A48">University Paris-Sud, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name><affiliation><nlm:aff id="A49">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Van Den Ouweland, Ans" sort="Van Den Ouweland, Ans" uniqKey="Van Den Ouweland A" first="Ans" last="Van Den Ouweland">Ans Van Den Ouweland</name><affiliation><nlm:aff id="A98">Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wen, Wanqing" sort="Wen, Wanqing" uniqKey="Wen W" first="Wanqing" last="Wen">Wanqing Wen</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A99">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A100">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Wu, Anna" sort="Wu, Anna" uniqKey="Wu A" first="Anna" last="Wu">Anna Wu</name><affiliation><nlm:aff id="A49">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng Har" last="Yip">Cheng Har Yip</name><affiliation><nlm:aff id="A94">Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="A101">Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Zheng, Ying" sort="Zheng, Ying" uniqKey="Zheng Y" first="Ying" last="Zheng">Ying Zheng</name><affiliation><nlm:aff id="A102">Shanghai Municipal Center for Disease Control and Prevention, Shanghai, PR China</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A35">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A38">Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec, Canada</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A6">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A2">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium.</p></sec><sec id="S3"><title>Results</title><p id="P3">Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 (conditional p = 2.51 × 10<sup>−4</sup>; OR = 1.04; 95% CI 1.02–1.07) and rs77928427 (p = 1.86 × 10<sup>−4</sup>; OR = 1.04; 95% CI 1.02–1.07). Functional annotation using data from the Encyclopedia of DNA Elements (ENCODE) project revealed two putative functional variants, rs62331150 and rs73838678 in linkage disequilibrium (LD) with rs9790517 (r<sup>2</sup> ≥ 0.90) residing in the active promoter or enhancer, respectively, of the nearest gene, <italic>TET2</italic>. Both variants are located in DNase I hypersensitivity and transcription factor binding sites. Using data from both The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), we showed that rs62331150 was associated with level of expression of <italic>TET2</italic> in breast normal and tumor tissue.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Our study identified two independent association signals at 4q24 in relation to breast cancer risk and suggested that observed association in this locus may be mediated through the regulation of <italic>TET2</italic>.</p></sec><sec id="S5"><title>Impact</title><p id="P5">Fine-mapping study with large sample size warranted for identification of independent loci for breast cancer risk.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9200608</journal-id><journal-id journal-id-type="pubmed-jr-id">2299</journal-id><journal-id journal-id-type="nlm-ta">Cancer Epidemiol Biomarkers Prev</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Epidemiol. Biomarkers Prev.</journal-id><journal-title-group><journal-title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</journal-title></journal-title-group><issn pub-type="ppub">1055-9965</issn><issn pub-type="epub">1538-7755</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26354892</article-id><article-id pub-id-type="pmc">4633342</article-id><article-id pub-id-type="doi">10.1158/1055-9965.EPI-15-0363</article-id><article-id pub-id-type="manuscript">NIHMS728130</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk</article-title></title-group><contrib-group><contrib 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contrib-type="author"><name><surname>Kang</surname><given-names>Daehee</given-names></name><xref ref-type="aff" rid="A58">58</xref><xref ref-type="aff" rid="A30">30</xref><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Khan</surname><given-names>Sofia</given-names></name><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Knight</surname><given-names>Julia A.</given-names></name><xref ref-type="aff" rid="A60">60</xref><xref ref-type="aff" rid="A61">61</xref></contrib><contrib contrib-type="author"><name><surname>Kosma</surname><given-names>Veli-Matti</given-names></name><xref ref-type="aff" rid="A62">62</xref></contrib><contrib contrib-type="author"><name><surname>Lambrechts</surname><given-names>Diether</given-names></name><xref ref-type="aff" rid="A63">63</xref><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Marchand</surname><given-names>Loic 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rid="A68">68</xref></contrib><contrib contrib-type="author"><name><surname>Margolin</surname><given-names>Sara</given-names></name><xref ref-type="aff" rid="A69">69</xref></contrib><contrib contrib-type="author"><name><surname>Marme</surname><given-names>Frederik</given-names></name><xref ref-type="aff" rid="A70">70</xref><xref ref-type="aff" rid="A71">71</xref></contrib><contrib contrib-type="author"><name><surname>Matsuo</surname><given-names>Keitaro</given-names></name><xref ref-type="aff" rid="A72">72</xref></contrib><contrib contrib-type="author"><name><surname>McLean</surname><given-names>Catriona A.</given-names></name><xref ref-type="aff" rid="A73">73</xref></contrib><contrib contrib-type="author"><name><surname>Meindl</surname><given-names>Alfons</given-names></name><xref ref-type="aff" rid="A74">74</xref></contrib><contrib contrib-type="author"><name><surname>Muir</surname><given-names>Kenneth</given-names></name><xref ref-type="aff" rid="A68">68</xref><xref ref-type="aff" 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contrib-type="author"><name><surname>Putti</surname><given-names>Thomas Choudary</given-names></name><xref ref-type="aff" rid="A82">82</xref></contrib><contrib contrib-type="author"><name><surname>Rudolph</surname><given-names>Anja</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Sangrajrang</surname><given-names>Suleeporn</given-names></name><xref ref-type="aff" rid="A83">83</xref></contrib><contrib contrib-type="author"><name><surname>Sawyer</surname><given-names>Elinor J.</given-names></name><xref ref-type="aff" rid="A84">84</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Marjanka K.</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Schmutzler</surname><given-names>Rita K.</given-names></name><xref ref-type="aff" rid="A85">85</xref><xref ref-type="aff" rid="A86">86</xref><xref ref-type="aff" rid="A87">87</xref><xref ref-type="aff" rid="A88">88</xref></contrib><contrib contrib-type="author"><name><surname>Shen</surname><given-names>Chen-Yang</given-names></name><xref ref-type="aff" rid="A89">89</xref><xref ref-type="aff" rid="A90">90</xref></contrib><contrib contrib-type="author"><name><surname>Shi</surname><given-names>Jiajun</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shrubsole</surname><given-names>Martha J</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Southey</surname><given-names>Melissa C.</given-names></name><xref ref-type="aff" rid="A91">91</xref></contrib><contrib contrib-type="author"><name><surname>Swerdlow</surname><given-names>Anthony</given-names></name><xref ref-type="aff" rid="A92">92</xref></contrib><contrib contrib-type="author"><name><surname>Teo</surname><given-names>Soo Hwang</given-names></name><xref ref-type="aff" rid="A93">93</xref><xref ref-type="aff" rid="A94">94</xref></contrib><contrib contrib-type="author"><name><surname>Thienpont</surname><given-names>Bernard</given-names></name><xref ref-type="aff" rid="A63">63</xref><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Toland</surname><given-names>Amanda Ewart</given-names></name><xref ref-type="aff" rid="A95">95</xref></contrib><contrib contrib-type="author"><name><surname>Tollenaar</surname><given-names>Robert A.E.M.</given-names></name><xref ref-type="aff" rid="A96">96</xref></contrib><contrib contrib-type="author"><name><surname>Tomlinson</surname><given-names>Ian P.M.</given-names></name><xref ref-type="aff" rid="A97">97</xref></contrib><contrib contrib-type="author"><name><surname>Truong</surname><given-names>Thérèse</given-names></name><xref ref-type="aff" rid="A47">47</xref><xref ref-type="aff" rid="A48">48</xref></contrib><contrib contrib-type="author"><name><surname>Tseng</surname><given-names>Chiu-chen</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>van den Ouweland</surname><given-names>Ans</given-names></name><xref ref-type="aff" rid="A98">98</xref></contrib><contrib contrib-type="author"><name><surname>Wen</surname><given-names>Wanqing</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Winqvist</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="A99">99</xref><xref ref-type="aff" rid="A100">100</xref></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Yip</surname><given-names>Cheng Har</given-names></name><xref ref-type="aff" rid="A94">94</xref></contrib><contrib contrib-type="author"><name><surname>Zamora</surname><given-names>M. Pilar</given-names></name><xref ref-type="aff" rid="A101">101</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Ying</given-names></name><xref ref-type="aff" rid="A102">102</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D.P.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Simard</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</aff><aff id="A2"><label>2</label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff><aff id="A3"><label>3</label>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</aff><aff id="A4"><label>4</label>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia</aff><aff id="A5"><label>5</label>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Victoria, Australia</aff><aff id="A6"><label>6</label>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</aff><aff id="A7"><label>7</label>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</aff><aff id="A8"><label>8</label>Department of Molecular Genetics, University of Toronto, Toronto, Canada</aff><aff id="A9"><label>9</label>Department of Epidemiology, University of California Irvine, Irvine, CA, USA</aff><aff id="A10"><label>10</label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A11"><label>11</label>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</aff><aff id="A12"><label>12</label>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</aff><aff id="A13"><label>13</label>Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</aff><aff id="A14"><label>14</label>International Epidemiology Institute, Rockville, MD, USA</aff><aff id="A15"><label>15</label>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</aff><aff id="A16"><label>16</label>Copenhagen General Population Study, Herlev Hospital, Herlev, Denmark</aff><aff id="A17"><label>17</label>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A18"><label>18</label>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</aff><aff id="A19"><label>19</label>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</aff><aff id="A20"><label>20</label>University of Tübingen, Tübingen, Germany</aff><aff id="A21"><label>21</label>German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A22"><label>22</label>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A23"><label>23</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</aff><aff id="A24"><label>24</label>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</aff><aff id="A25"><label>25</label>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Bochum, Germany</aff><aff id="A26"><label>26</label>Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A27"><label>27</label>Molecular Epidemiology Group, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A28"><label>28</label>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands</aff><aff id="A29"><label>29</label>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A30"><label>30</label>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea</aff><aff id="A31"><label>31</label>Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea</aff><aff id="A32"><label>32</label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</aff><aff id="A33"><label>33</label>Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, UK</aff><aff id="A34"><label>34</label>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</aff><aff id="A35"><label>35</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A36"><label>36</label>Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A37"><label>37</label>Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A38"><label>38</label>Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec, Canada</aff><aff id="A39"><label>39</label>Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</aff><aff id="A40"><label>40</label>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, USA</aff><aff id="A41"><label>41</label>Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</aff><aff id="A42"><label>42</label>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A43"><label>43</label>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Athens, Greece</aff><aff id="A44"><label>44</label>International Agency for Research on Cancer, Lyon, France</aff><aff id="A45"><label>45</label>Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</aff><aff id="A46"><label>46</label>Department of Surgery, Oulu University Hospital and University of Oulu, Oulu, Finland</aff><aff id="A47"><label>47</label>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</aff><aff id="A48"><label>48</label>University Paris-Sud, Villejuif, France</aff><aff id="A49"><label>49</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</aff><aff id="A50"><label>50</label>Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A51"><label>51</label>Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore</aff><aff id="A52"><label>52</label>Department of Surgery, National University Health System, Singapore</aff><aff id="A53"><label>53</label>Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A54"><label>54</label>Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</aff><aff id="A55"><label>55</label>Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia</aff><aff id="A56"><label>56</label>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi, Japan</aff><aff id="A57"><label>57</label>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff><aff id="A58"><label>58</label>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea</aff><aff id="A59"><label>59</label>Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, FI-00029 HUS, Finland</aff><aff id="A60"><label>60</label>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada</aff><aff id="A61"><label>61</label>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, M5S 1A8, Canada</aff><aff id="A62"><label>62</label>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A63"><label>63</label>Vesalius Research Center, Leuven, Belgium</aff><aff id="A64"><label>64</label>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</aff><aff id="A65"><label>65</label>University of Hawaii Cancer Center, Honolulu, HI, USA</aff><aff id="A66"><label>66</label>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE, Sweden</aff><aff id="A67"><label>67</label>Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</aff><aff id="A68"><label>68</label>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy</aff><aff id="A69"><label>69</label>Department of Oncology - Pathology, Karolinska Institutet, Stockholm SE, Sweden</aff><aff id="A70"><label>70</label>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</aff><aff id="A71"><label>71</label>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</aff><aff id="A72"><label>72</label>Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan</aff><aff id="A73"><label>73</label>Anatomical Pathology, The Alfred Hospital, Melbourne, Victoria, Australia</aff><aff id="A74"><label>74</label>Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</aff><aff id="A75"><label>75</label>Institute of Population Health, University of Manchester, Manchester, UK</aff><aff id="A76"><label>76</label>Beckman Research Institute of City of Hope, Duarte, CA, USA</aff><aff id="A77"><label>77</label>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Ullernchausseen, Oslo, Norway</aff><aff id="A78"><label>78</label>K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Kirkeveien, Oslo, Norway</aff><aff id="A79"><label>79</label>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</aff><aff id="A80"><label>80</label>Division of Breast Cancer Research, Institute of Cancer Research, London, UK; Cancer Research, Institute of Cancer Research, London, UK</aff><aff id="A81"><label>81</label>IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy</aff><aff id="A82"><label>82</label>Department of Pathology, National University Health System, Singapore</aff><aff id="A83"><label>83</label>National Cancer Institute, Bangkok, Thailand</aff><aff id="A84"><label>84</label>Research Oncology, Guy’s Hospital, King's College London, London, UK</aff><aff id="A85"><label>85</label>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</aff><aff id="A86"><label>86</label>Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany</aff><aff id="A87"><label>87</label>Center for Molecular Medicine, University Hospital of Cologne, Cologne, Germany</aff><aff id="A88"><label>88</label>Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</aff><aff id="A89"><label>89</label>School of Public Health, China Medical University, Taichung, Taiwan</aff><aff id="A90"><label>90</label>Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</aff><aff id="A91"><label>91</label>Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia</aff><aff id="A92"><label>92</label>Division of Genetics and Epidemiology and Division of Breast Cancer Research, Institute of Cancer Research, London, UK</aff><aff id="A93"><label>93</label>Cancer Research Initiatives Foundation, Subang Jaya, Selangor, Malaysia</aff><aff id="A94"><label>94</label>Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</aff><aff id="A95"><label>95</label>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA</aff><aff id="A96"><label>96</label>Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A97"><label>97</label>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, UK</aff><aff id="A98"><label>98</label>Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A99"><label>99</label>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry, University of Oulu, Oulu, Finland</aff><aff id="A100"><label>100</label>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</aff><aff id="A101"><label>101</label>Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</aff><aff id="A102"><label>102</label>Shanghai Municipal Center for Disease Control and Prevention, Shanghai, PR China</aff><author-notes><corresp id="cor1"><label>*</label>Correspondence to: Wei Zheng, MD, PhD, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 2525 West End Avenue, 8th Floor, Nashville, TN 37203-1738, USA, Phone: (615) 936-0682; Fax: (615) 936-8241, <email>wei.zheng@vanderbilt.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>8</day><month>10</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>09</day><month>9</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>11</month><year>2016</year></pub-date><volume>24</volume><issue>11</issue><fpage>1680</fpage><lpage>1691</lpage><pmc-comment>elocation-id from pubmed: 10.1158/1055-9965.EPI-15-0363</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium.</p></sec><sec id="S3"><title>Results</title><p id="P3">Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 (conditional p = 2.51 × 10<sup>−4</sup>; OR = 1.04; 95% CI 1.02–1.07) and rs77928427 (p = 1.86 × 10<sup>−4</sup>; OR = 1.04; 95% CI 1.02–1.07). Functional annotation using data from the Encyclopedia of DNA Elements (ENCODE) project revealed two putative functional variants, rs62331150 and rs73838678 in linkage disequilibrium (LD) with rs9790517 (r<sup>2</sup> ≥ 0.90) residing in the active promoter or enhancer, respectively, of the nearest gene, <italic>TET2</italic>. Both variants are located in DNase I hypersensitivity and transcription factor binding sites. Using data from both The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), we showed that rs62331150 was associated with level of expression of <italic>TET2</italic> in breast normal and tumor tissue.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Our study identified two independent association signals at 4q24 in relation to breast cancer risk and suggested that observed association in this locus may be mediated through the regulation of <italic>TET2</italic>.</p></sec><sec id="S5"><title>Impact</title><p id="P5">Fine-mapping study with large sample size warranted for identification of independent loci for breast cancer risk.</p></sec></abstract><kwd-group><kwd>Breast Cancer</kwd><kwd>Genetics</kwd><kwd>GWAS</kwd><kwd>4q24</kwd><kwd>TET2</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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