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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inflammatory markers and risk of epithelial ovarian cancer by tumor subtypes: the EPIC cohort</title><author><name sortKey="Ose, Jennifer" sort="Ose, Jennifer" uniqKey="Ose J" first="Jennifer" last="Ose">Jennifer Ose</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schock, Helena" sort="Schock, Helena" uniqKey="Schock H" first="Helena" last="Schock">Helena Schock</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Tjonneland, Anne" sort="Tjonneland, Anne" uniqKey="Tjonneland A" first="Anne" last="Tjonneland">Anne Tjonneland</name><affiliation><nlm:aff id="A2">Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hansen, Louise" sort="Hansen, Louise" uniqKey="Hansen L" first="Louise" last="Hansen">Louise Hansen</name><affiliation><nlm:aff id="A2">Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation><nlm:aff id="A3">Department of Public Health, Section for Epidemiology Danish Cancer, Aarhus University, Aarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name><affiliation><nlm:aff id="A4">INSERM, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health team, F-94805, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Univ Paris Sud, UMRS 1018, F-94805, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">IGR, F-94805, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Clavel Chapelon, Francoise" sort="Clavel Chapelon, Francoise" uniqKey="Clavel Chapelon F" first="Francoise" last="Clavel-Chapelon">Francoise Clavel-Chapelon</name><affiliation><nlm:aff id="A4">INSERM, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health team, F-94805, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Univ Paris Sud, UMRS 1018, F-94805, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">IGR, F-94805, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="A7">Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Australia.</nlm:aff></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation><nlm:aff id="A9">Department of Epidemiology, German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke, Nuthetal, Germany</nlm:aff></affiliation></author><author><name sortKey="Trichopolou, Antonia" sort="Trichopolou, Antonia" uniqKey="Trichopolou A" first="Antonia" last="Trichopolou">Antonia Trichopolou</name><affiliation><nlm:aff id="A10">Hellenic Health Foundation, 13 Kaisareias Street, Athens, GR-115 27, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M. Asias Street, Goudi, GR-115 27, Athens, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens, GR-115 27, Greece</nlm:aff></affiliation></author><author><name sortKey="Benetou, Vassiliki" sort="Benetou, Vassiliki" uniqKey="Benetou V" first="Vassiliki" last="Benetou">Vassiliki Benetou</name><affiliation><nlm:aff id="A10">Hellenic Health Foundation, 13 Kaisareias Street, Athens, GR-115 27, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M. Asias Street, Goudi, GR-115 27, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name><affiliation><nlm:aff id="A11">Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M. Asias Street, Goudi, GR-115 27, Athens, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens, GR-115 27, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Masala, Giovanna" sort="Masala, Giovanna" uniqKey="Masala G" first="Giovanna" last="Masala">Giovanna Masala</name><affiliation><nlm:aff id="A14">Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence – Italy</nlm:aff></affiliation></author><author><name sortKey="Tagliabue, Giovanna" sort="Tagliabue, Giovanna" uniqKey="Tagliabue G" first="Giovanna" last="Tagliabue">Giovanna Tagliabue</name><affiliation><nlm:aff id="A15">Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name><affiliation><nlm:aff id="A16">Cancer Registry and Histopathology Unit, “Civic - M.P. Arezzo” Hospita, ASP Ragusa, Italy</nlm:aff></affiliation></author><author><name sortKey="Sacerdote, Carlotta" sort="Sacerdote, Carlotta" uniqKey="Sacerdote C" first="Carlotta" last="Sacerdote">Carlotta Sacerdote</name><affiliation><nlm:aff id="A17">Center for Cancer Prevention (CPOPiemonte),Turin, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Human Genetic Foundation, Torino, Italy</nlm:aff></affiliation></author><author><name sortKey="Mattiello, Amalia" sort="Mattiello, Amalia" uniqKey="Mattiello A" first="Amalia" last="Mattiello">Amalia Mattiello</name><affiliation><nlm:aff id="A19">Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="De Mesquita, H Bas Bueno" sort="De Mesquita, H Bas Bueno" uniqKey="De Mesquita H" first="H. Bas Bueno" last="De Mesquita">H. Bas Bueno De Mesquita</name><affiliation><nlm:aff id="A20">Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Peeters, Petra H M" sort="Peeters, Petra H M" uniqKey="Peeters P" first="Petra H M" last="Peeters">Petra H M. Peeters</name><affiliation><nlm:aff id="A24">Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</nlm:aff></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name><affiliation><nlm:aff id="A25">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:aff id="A26">Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Cancer Registry of Norway, Oslo, Norway.</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Department of Genetic Epidemiology, Folkhälsan Research Center, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Gram, Inger T" sort="Gram, Inger T" uniqKey="Gram I" first="Inger T" last="Gram">Inger T. Gram</name><affiliation><nlm:aff id="A26">Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</nlm:aff></affiliation></author><author><name sortKey="Sanchez, Soledad" sort="Sanchez, Soledad" uniqKey="Sanchez S" first="Soledad" last="Sánchez">Soledad Sánchez</name><affiliation><nlm:aff id="A30">Public Health Directorate, Asturias, Spain</nlm:aff></affiliation></author><author><name sortKey="Obon Santacana, Mireia" sort="Obon Santacana, Mireia" uniqKey="Obon Santacana M" first="Mireia" last="Obon-Santacana">Mireia Obon-Santacana</name><affiliation><nlm:aff id="A31">Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Sanchez Perez, Maria Jose" sort="Sanchez Perez, Maria Jose" uniqKey="Sanchez Perez M" first="Maria-José" last="Sànchez-Pérez">Maria-José Sànchez-Pérez</name><affiliation><nlm:aff id="A32">CIBER de Epidemiología y Salud Pública (CIBERESP), Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Andalusian School of Public Health. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain</nlm:aff></affiliation></author><author><name sortKey="Larra Aga, Nerea" sort="Larra Aga, Nerea" uniqKey="Larra Aga N" first="Nerea" last="Larra Aga">Nerea Larra Aga</name><affiliation><nlm:aff id="A32">CIBER de Epidemiología y Salud Pública (CIBERESP), Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, Spain</nlm:aff></affiliation></author><author><name sortKey="Casta O, Jose Maria Huerta" sort="Casta O, Jose Maria Huerta" uniqKey="Casta O J" first="José María Huerta" last="Casta O">José María Huerta Casta O</name><affiliation><nlm:aff id="A32">CIBER de Epidemiología y Salud Pública (CIBERESP), Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Department of Epidemiology, Murcia Regional Health Authority, Spain</nlm:aff></affiliation></author><author><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><affiliation><nlm:aff id="A32">CIBER de Epidemiología y Salud Pública (CIBERESP), Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Navarre Public Health Institute, Pamplona, Spain</nlm:aff></affiliation></author><author><name sortKey="Br Ndstedt, Jenny" sort="Br Ndstedt, Jenny" uniqKey="Br Ndstedt J" first="Jenny" last="Br Ndstedt">Jenny Br Ndstedt</name><affiliation><nlm:aff id="A37">Department of Surgery, Skåne University Hospital, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Skåne University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lundin, Eva" sort="Lundin, Eva" uniqKey="Lundin E" first="Eva" last="Lundin">Eva Lundin</name><affiliation><nlm:aff id="A39">Department of Medical Biosciences, Pathology, Umea° University, Umea°, Sweden</nlm:aff></affiliation></author><author><name sortKey="Idahl, Annika" sort="Idahl, Annika" uniqKey="Idahl A" first="Annika" last="Idahl">Annika Idahl</name><affiliation><nlm:aff id="A40">Department of Clinical Sciences, Obstetrics and Gynecology, Umea° University, Umea°, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Department of Public Health and Clinical Medicine, Nutritional research, Umea° University, Umea°, Sweden</nlm:aff></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="A42">Cancer Epidemiology Unit, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A43">Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Rinaldi, Sabina" sort="Rinaldi, Sabina" uniqKey="Rinaldi S" first="Sabina" last="Rinaldi">Sabina Rinaldi</name><affiliation><nlm:aff id="A44">Biomarkers Group, International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name><affiliation><nlm:aff id="A44">Biomarkers Group, International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Merrit, Melissa A" sort="Merrit, Melissa A" uniqKey="Merrit M" first="Melissa A" last="Merrit">Melissa A. Merrit</name><affiliation><nlm:aff id="A45">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name><affiliation><nlm:aff id="A45">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:aff id="A45">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Fortner, Renee T" sort="Fortner, Renee T" uniqKey="Fortner R" first="Renée T" last="Fortner">Renée T. Fortner</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25855626</idno><idno type="pmc">4454588</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454588</idno><idno type="RBID">PMC:4454588</idno><idno type="doi">10.1158/1055-9965.EPI-14-1279-T</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002096</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002096</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Inflammatory markers and risk of epithelial ovarian cancer by tumor subtypes: the EPIC cohort</title><author><name sortKey="Ose, Jennifer" sort="Ose, Jennifer" uniqKey="Ose J" first="Jennifer" last="Ose">Jennifer Ose</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schock, Helena" sort="Schock, Helena" uniqKey="Schock H" first="Helena" last="Schock">Helena Schock</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Tjonneland, Anne" sort="Tjonneland, Anne" uniqKey="Tjonneland A" first="Anne" last="Tjonneland">Anne Tjonneland</name><affiliation><nlm:aff id="A2">Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hansen, Louise" sort="Hansen, Louise" uniqKey="Hansen L" first="Louise" last="Hansen">Louise Hansen</name><affiliation><nlm:aff id="A2">Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation><nlm:aff id="A3">Department of Public Health, Section for Epidemiology Danish Cancer, Aarhus University, Aarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name><affiliation><nlm:aff id="A4">INSERM, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health team, F-94805, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Univ Paris Sud, UMRS 1018, F-94805, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">IGR, F-94805, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Clavel Chapelon, Francoise" sort="Clavel Chapelon, Francoise" uniqKey="Clavel Chapelon F" first="Francoise" last="Clavel-Chapelon">Francoise Clavel-Chapelon</name><affiliation><nlm:aff id="A4">INSERM, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health team, F-94805, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Univ Paris Sud, UMRS 1018, F-94805, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">IGR, F-94805, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="A7">Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Australia.</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Australia.</nlm:aff></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation><nlm:aff id="A9">Department of Epidemiology, German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke, Nuthetal, Germany</nlm:aff></affiliation></author><author><name sortKey="Trichopolou, Antonia" sort="Trichopolou, Antonia" uniqKey="Trichopolou A" first="Antonia" last="Trichopolou">Antonia Trichopolou</name><affiliation><nlm:aff id="A10">Hellenic Health Foundation, 13 Kaisareias Street, Athens, GR-115 27, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M. Asias Street, Goudi, GR-115 27, Athens, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens, GR-115 27, Greece</nlm:aff></affiliation></author><author><name sortKey="Benetou, Vassiliki" sort="Benetou, Vassiliki" uniqKey="Benetou V" first="Vassiliki" last="Benetou">Vassiliki Benetou</name><affiliation><nlm:aff id="A10">Hellenic Health Foundation, 13 Kaisareias Street, Athens, GR-115 27, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M. Asias Street, Goudi, GR-115 27, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name><affiliation><nlm:aff id="A11">Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M. Asias Street, Goudi, GR-115 27, Athens, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens, GR-115 27, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Masala, Giovanna" sort="Masala, Giovanna" uniqKey="Masala G" first="Giovanna" last="Masala">Giovanna Masala</name><affiliation><nlm:aff id="A14">Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence – Italy</nlm:aff></affiliation></author><author><name sortKey="Tagliabue, Giovanna" sort="Tagliabue, Giovanna" uniqKey="Tagliabue G" first="Giovanna" last="Tagliabue">Giovanna Tagliabue</name><affiliation><nlm:aff id="A15">Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name><affiliation><nlm:aff id="A16">Cancer Registry and Histopathology Unit, “Civic - M.P. Arezzo” Hospita, ASP Ragusa, Italy</nlm:aff></affiliation></author><author><name sortKey="Sacerdote, Carlotta" sort="Sacerdote, Carlotta" uniqKey="Sacerdote C" first="Carlotta" last="Sacerdote">Carlotta Sacerdote</name><affiliation><nlm:aff id="A17">Center for Cancer Prevention (CPOPiemonte),Turin, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Human Genetic Foundation, Torino, Italy</nlm:aff></affiliation></author><author><name sortKey="Mattiello, Amalia" sort="Mattiello, Amalia" uniqKey="Mattiello A" first="Amalia" last="Mattiello">Amalia Mattiello</name><affiliation><nlm:aff id="A19">Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="De Mesquita, H Bas Bueno" sort="De Mesquita, H Bas Bueno" uniqKey="De Mesquita H" first="H. Bas Bueno" last="De Mesquita">H. Bas Bueno De Mesquita</name><affiliation><nlm:aff id="A20">Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Peeters, Petra H M" sort="Peeters, Petra H M" uniqKey="Peeters P" first="Petra H M" last="Peeters">Petra H M. Peeters</name><affiliation><nlm:aff id="A24">Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</nlm:aff></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name><affiliation><nlm:aff id="A25">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:aff id="A26">Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Cancer Registry of Norway, Oslo, Norway.</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Department of Genetic Epidemiology, Folkhälsan Research Center, Helsinki, Finland.</nlm:aff></affiliation></author><author><name sortKey="Gram, Inger T" sort="Gram, Inger T" uniqKey="Gram I" first="Inger T" last="Gram">Inger T. Gram</name><affiliation><nlm:aff id="A26">Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</nlm:aff></affiliation></author><author><name sortKey="Sanchez, Soledad" sort="Sanchez, Soledad" uniqKey="Sanchez S" first="Soledad" last="Sánchez">Soledad Sánchez</name><affiliation><nlm:aff id="A30">Public Health Directorate, Asturias, Spain</nlm:aff></affiliation></author><author><name sortKey="Obon Santacana, Mireia" sort="Obon Santacana, Mireia" uniqKey="Obon Santacana M" first="Mireia" last="Obon-Santacana">Mireia Obon-Santacana</name><affiliation><nlm:aff id="A31">Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Sanchez Perez, Maria Jose" sort="Sanchez Perez, Maria Jose" uniqKey="Sanchez Perez M" first="Maria-José" last="Sànchez-Pérez">Maria-José Sànchez-Pérez</name><affiliation><nlm:aff id="A32">CIBER de Epidemiología y Salud Pública (CIBERESP), Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Andalusian School of Public Health. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain</nlm:aff></affiliation></author><author><name sortKey="Larra Aga, Nerea" sort="Larra Aga, Nerea" uniqKey="Larra Aga N" first="Nerea" last="Larra Aga">Nerea Larra Aga</name><affiliation><nlm:aff id="A32">CIBER de Epidemiología y Salud Pública (CIBERESP), Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, Spain</nlm:aff></affiliation></author><author><name sortKey="Casta O, Jose Maria Huerta" sort="Casta O, Jose Maria Huerta" uniqKey="Casta O J" first="José María Huerta" last="Casta O">José María Huerta Casta O</name><affiliation><nlm:aff id="A32">CIBER de Epidemiología y Salud Pública (CIBERESP), Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Department of Epidemiology, Murcia Regional Health Authority, Spain</nlm:aff></affiliation></author><author><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><affiliation><nlm:aff id="A32">CIBER de Epidemiología y Salud Pública (CIBERESP), Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Navarre Public Health Institute, Pamplona, Spain</nlm:aff></affiliation></author><author><name sortKey="Br Ndstedt, Jenny" sort="Br Ndstedt, Jenny" uniqKey="Br Ndstedt J" first="Jenny" last="Br Ndstedt">Jenny Br Ndstedt</name><affiliation><nlm:aff id="A37">Department of Surgery, Skåne University Hospital, Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Skåne University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lundin, Eva" sort="Lundin, Eva" uniqKey="Lundin E" first="Eva" last="Lundin">Eva Lundin</name><affiliation><nlm:aff id="A39">Department of Medical Biosciences, Pathology, Umea° University, Umea°, Sweden</nlm:aff></affiliation></author><author><name sortKey="Idahl, Annika" sort="Idahl, Annika" uniqKey="Idahl A" first="Annika" last="Idahl">Annika Idahl</name><affiliation><nlm:aff id="A40">Department of Clinical Sciences, Obstetrics and Gynecology, Umea° University, Umea°, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Department of Public Health and Clinical Medicine, Nutritional research, Umea° University, Umea°, Sweden</nlm:aff></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="A42">Cancer Epidemiology Unit, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff id="A43">Department of Public Health and Primary Care, University of Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Rinaldi, Sabina" sort="Rinaldi, Sabina" uniqKey="Rinaldi S" first="Sabina" last="Rinaldi">Sabina Rinaldi</name><affiliation><nlm:aff id="A44">Biomarkers Group, International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name><affiliation><nlm:aff id="A44">Biomarkers Group, International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Merrit, Melissa A" sort="Merrit, Melissa A" uniqKey="Merrit M" first="Melissa A" last="Merrit">Melissa A. Merrit</name><affiliation><nlm:aff id="A45">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name><affiliation><nlm:aff id="A45">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:aff id="A45">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Fortner, Renee T" sort="Fortner, Renee T" uniqKey="Fortner R" first="Renée T" last="Fortner">Renée T. Fortner</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Evidence suggests an etiologic role for inflammation in ovarian carcinogenesis and heterogeneity between tumor subtypes and anthropometric indices. Prospective studies on circulating inflammatory markers and epithelial invasive ovarian cancer (EOC) have predominantly investigated overall risk; data characterizing risk by tumor characteristics (histology, grade, stage, dualistic model of ovarian carcinogenesis) and anthropometric indices are sparse.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate C-reactive protein (CRP), interleukin-6 (IL-6), and EOC risk by tumor characteristics. A total of 754 eligible EOC cases were identified; two controls (n=1,497) were matched per case. We used multivariable conditional logistic regression to assess associations.</p></sec><sec id="S3"><title>Results</title><p id="P3">CRP and IL-6 were not associated with overall EOC risk. However, consistent with prior research, CRP >10 vs. CRP ≤1 mg/L was associated with higher overall EOC risk (OR=1.67 [1.03 - 2.70]). We did not observe significant associations or heterogeneity in analyses by tumor characteristics. In analyses stratified by waist circumference, inflammatory markers were associated with higher risk among women with higher waist circumference; no association was observed for women with normal waist circumference: (e.g., IL-6: waist ≤80: OR<sub>log2</sub>=0.97 [0.81 - 1.16]; waist >88: OR<sub>log2</sub>=1.78 [1.28 - 2.48], p<sub>heterogeneity</sub> ≤0.01).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Our data suggest that high CRP is associated with increased risk of overall EOC, and that IL-6 and CRP may be associated with EOC risk among women with higher adiposity.</p></sec><sec id="S5"><title>Impact</title><p id="P5">Our data add to global evidence that ovarian carcinogenesis may be promoted by an inflammatory milieu.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9200608</journal-id><journal-id journal-id-type="pubmed-jr-id">2299</journal-id><journal-id journal-id-type="nlm-ta">Cancer Epidemiol Biomarkers Prev</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Epidemiol. Biomarkers Prev.</journal-id><journal-title-group><journal-title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</journal-title></journal-title-group><issn pub-type="ppub">1055-9965</issn><issn pub-type="epub">1538-7755</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25855626</article-id><article-id pub-id-type="pmc">4454588</article-id><article-id pub-id-type="doi">10.1158/1055-9965.EPI-14-1279-T</article-id><article-id pub-id-type="manuscript">EMS62886</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Inflammatory markers and risk of epithelial ovarian cancer by tumor subtypes: the EPIC cohort</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ose</surname><given-names>Jennifer</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Schock</surname><given-names>Helena</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tjonneland</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hansen</surname><given-names>Louise</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Overvad</surname><given-names>Kim</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Dossus</surname><given-names>Laure</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Clavel-Chapelon</surname><given-names>Francoise</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Baglietto</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Boeing</surname><given-names>Heiner</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Trichopolou</surname><given-names>Antonia</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Benetou</surname><given-names>Vassiliki</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Lagiou</surname><given-names>Pagona</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A12">12</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Masala</surname><given-names>Giovanna</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Tagliabue</surname><given-names>Giovanna</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Tumino</surname><given-names>Rosario</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Sacerdote</surname><given-names>Carlotta</given-names></name><xref ref-type="aff" rid="A17">17</xref><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Mattiello</surname><given-names>Amalia</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>de Mesquita</surname><given-names>H.Bas Bueno</given-names></name><xref ref-type="aff" rid="A20">20</xref><xref ref-type="aff" rid="A21">21</xref><xref ref-type="aff" rid="A22">22</xref><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Peeters</surname><given-names>Petra H M</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Onland-Moret</surname><given-names>N Charlotte</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Weiderpass</surname><given-names>Elisabete</given-names></name><xref ref-type="aff" rid="A26">26</xref><xref ref-type="aff" rid="A27">27</xref><xref ref-type="aff" rid="A28">28</xref><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Gram</surname><given-names>Inger T</given-names></name><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Sánchez</surname><given-names>Soledad</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Obon-Santacana</surname><given-names>Mireia</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Sànchez-Pérez</surname><given-names>Maria-José</given-names></name><xref ref-type="aff" rid="A32">32</xref><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Larrañaga</surname><given-names>Nerea</given-names></name><xref ref-type="aff" rid="A32">32</xref><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Castaño</surname><given-names>José María Huerta</given-names></name><xref ref-type="aff" rid="A32">32</xref><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Ardanaz</surname><given-names>Eva</given-names></name><xref ref-type="aff" rid="A32">32</xref><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Brändstedt</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="A37">37</xref><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Lundin</surname><given-names>Eva</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Idahl</surname><given-names>Annika</given-names></name><xref ref-type="aff" rid="A40">40</xref><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Travis</surname><given-names>Ruth C</given-names></name><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Khaw</surname><given-names>Kay-Tee</given-names></name><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Rinaldi</surname><given-names>Sabina</given-names></name><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Romieu</surname><given-names>Isabelle</given-names></name><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Merrit</surname><given-names>Melissa A</given-names></name><xref ref-type="aff" rid="A45">45</xref></contrib><contrib contrib-type="author"><name><surname>Gunter</surname><given-names>Marc J</given-names></name><xref ref-type="aff" rid="A45">45</xref></contrib><contrib contrib-type="author"><name><surname>Riboli</surname><given-names>Elio</given-names></name><xref ref-type="aff" rid="A45">45</xref></contrib><contrib contrib-type="author"><name><surname>Kaaks</surname><given-names>Rudolf</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Fortner</surname><given-names>Renée T</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A2"><label>2</label>Danish Cancer Society Research Center, Copenhagen, Denmark</aff><aff id="A3"><label>3</label>Department of Public Health, Section for Epidemiology Danish Cancer, Aarhus University, Aarhus, Denmark</aff><aff id="A4"><label>4</label>INSERM, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health team, F-94805, Villejuif, France</aff><aff id="A5"><label>5</label>Univ Paris Sud, UMRS 1018, F-94805, Villejuif, France</aff><aff id="A6"><label>6</label>IGR, F-94805, Villejuif, France</aff><aff id="A7"><label>7</label>Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Australia.</aff><aff id="A8"><label>8</label>Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Australia.</aff><aff id="A9"><label>9</label>Department of Epidemiology, German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke, Nuthetal, Germany</aff><aff id="A10"><label>10</label>Hellenic Health Foundation, 13 Kaisareias Street, Athens, GR-115 27, Greece</aff><aff id="A11"><label>11</label>Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M. Asias Street, Goudi, GR-115 27, Athens, Greece</aff><aff id="A12"><label>12</label>Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens, GR-115 27, Greece</aff><aff id="A13"><label>13</label>Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA</aff><aff id="A14"><label>14</label>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence – Italy</aff><aff id="A15"><label>15</label>Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy</aff><aff id="A16"><label>16</label>Cancer Registry and Histopathology Unit, “Civic - M.P. Arezzo” Hospita, ASP Ragusa, Italy</aff><aff id="A17"><label>17</label>Center for Cancer Prevention (CPOPiemonte),Turin, Italy</aff><aff id="A18"><label>18</label>Human Genetic Foundation, Torino, Italy</aff><aff id="A19"><label>19</label>Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy</aff><aff id="A20"><label>20</label>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</aff><aff id="A21"><label>21</label>Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands</aff><aff id="A22"><label>22</label>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom</aff><aff id="A23"><label>23</label>Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</aff><aff id="A24"><label>24</label>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</aff><aff id="A25"><label>25</label>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</aff><aff id="A26"><label>26</label>Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</aff><aff id="A27"><label>27</label>Cancer Registry of Norway, Oslo, Norway.</aff><aff id="A28"><label>28</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</aff><aff id="A29"><label>29</label>Department of Genetic Epidemiology, Folkhälsan Research Center, Helsinki, Finland.</aff><aff id="A30"><label>30</label>Public Health Directorate, Asturias, Spain</aff><aff id="A31"><label>31</label>Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</aff><aff id="A32"><label>32</label>CIBER de Epidemiología y Salud Pública (CIBERESP), Spain</aff><aff id="A33"><label>33</label>Andalusian School of Public Health. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain</aff><aff id="A34"><label>34</label>Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, Spain</aff><aff id="A35"><label>35</label>Department of Epidemiology, Murcia Regional Health Authority, Spain</aff><aff id="A36"><label>36</label>Navarre Public Health Institute, Pamplona, Spain</aff><aff id="A37"><label>37</label>Department of Surgery, Skåne University Hospital, Malmö, Sweden</aff><aff id="A38"><label>38</label>Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Skåne University Hospital, Lund, Sweden</aff><aff id="A39"><label>39</label>Department of Medical Biosciences, Pathology, Umea° University, Umea°, Sweden</aff><aff id="A40"><label>40</label>Department of Clinical Sciences, Obstetrics and Gynecology, Umea° University, Umea°, Sweden</aff><aff id="A41"><label>41</label>Department of Public Health and Clinical Medicine, Nutritional research, Umea° University, Umea°, Sweden</aff><aff id="A42"><label>42</label>Cancer Epidemiology Unit, University of Oxford, Oxford, UK</aff><aff id="A43"><label>43</label>Department of Public Health and Primary Care, University of Cambridge, United Kingdom</aff><aff id="A44"><label>44</label>Biomarkers Group, International Agency for Research on Cancer, Lyon, France</aff><aff id="A45"><label>45</label>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK</aff><author-notes><corresp id="CR1"><label>*</label><bold>Corresponding Author</bold>: Renée T. Fortner, German Cancer Research Center, Division of Cancer Epidemiology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Phone: + 49 (0) 6221 42 2241; Fax: + 49 (0) 6221 42 2203; <email>r.fortner@dkfz-heidelberg.de</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>5</day><month>5</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>08</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>12</month><year>2015</year></pub-date><volume>24</volume><issue>6</issue><fpage>951</fpage><lpage>961</lpage><pmc-comment>elocation-id from pubmed: 10.1158/1055-9965.EPI-14-1279-T</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">Evidence suggests an etiologic role for inflammation in ovarian carcinogenesis and heterogeneity between tumor subtypes and anthropometric indices. Prospective studies on circulating inflammatory markers and epithelial invasive ovarian cancer (EOC) have predominantly investigated overall risk; data characterizing risk by tumor characteristics (histology, grade, stage, dualistic model of ovarian carcinogenesis) and anthropometric indices are sparse.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate C-reactive protein (CRP), interleukin-6 (IL-6), and EOC risk by tumor characteristics. A total of 754 eligible EOC cases were identified; two controls (n=1,497) were matched per case. We used multivariable conditional logistic regression to assess associations.</p></sec><sec id="S3"><title>Results</title><p id="P3">CRP and IL-6 were not associated with overall EOC risk. However, consistent with prior research, CRP >10 vs. CRP ≤1 mg/L was associated with higher overall EOC risk (OR=1.67 [1.03 - 2.70]). We did not observe significant associations or heterogeneity in analyses by tumor characteristics. In analyses stratified by waist circumference, inflammatory markers were associated with higher risk among women with higher waist circumference; no association was observed for women with normal waist circumference: (e.g., IL-6: waist ≤80: OR<sub>log2</sub>=0.97 [0.81 - 1.16]; waist >88: OR<sub>log2</sub>=1.78 [1.28 - 2.48], p<sub>heterogeneity</sub> ≤0.01).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Our data suggest that high CRP is associated with increased risk of overall EOC, and that IL-6 and CRP may be associated with EOC risk among women with higher adiposity.</p></sec><sec id="S5"><title>Impact</title><p id="P5">Our data add to global evidence that ovarian carcinogenesis may be promoted by an inflammatory milieu.</p></sec></abstract><kwd-group><kwd>ovarian cancer</kwd><kwd>histological subtypes</kwd><kwd>obesity</kwd><kwd>inflammation</kwd><kwd>type I / type II model</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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