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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Common variants at the 19p13.1 and <italic>ZNF365</italic> loci are associated with ER subtypes of breast cancer and ovarian cancer risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers</title><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="A2">Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J." last="Ramus">Susan J. Ramus</name><affiliation><nlm:aff id="A4">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B." last="Kuchenbaecker">Karoline B. Kuchenbaecker</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="A5">Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City (Quebec), Canada</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A6">Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation><nlm:aff id="A6">Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Kirchhoff, Tomas" sort="Kirchhoff, Tomas" uniqKey="Kirchhoff T" first="Tomas" last="Kirchhoff">Tomas Kirchhoff</name><affiliation><nlm:aff id="A7">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lee, Andrew" sort="Lee, Andrew" uniqKey="Lee A" first="Andrew" last="Lee">Andrew Lee</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><nlm:aff id="A6">Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><nlm:aff id="A8">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon / Centre Léon Bérard, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A9">INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A10">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Cancer Care Ontario, Department of Molecular Genetics, University of Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Cancer Care Ontario, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Ontario Cancer Genetics Network: Cancer Care Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name><affiliation><nlm:aff id="A11">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Cancer Care Ontario, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="A11">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Cancer Care Ontario, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="A14">Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation><nlm:aff id="A15">Department of Clincial Genetics, Rigshospitalet, København, Denmark</nlm:aff></affiliation></author><author><name sortKey="Jensen, Uffe Birk" sort="Jensen, Uffe Birk" uniqKey="Jensen U" first="Uffe Birk" last="Jensen">Uffe Birk Jensen</name><affiliation><nlm:aff id="A16">Department of Clinical Genetics, Skejby Hospital, Århus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Skytte, Anne Bine" sort="Skytte, Anne Bine" uniqKey="Skytte A" first="Anne-Bine" last="Skytte">Anne-Bine Skytte</name><affiliation><nlm:aff id="A17">Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</nlm:aff></affiliation></author><author><name sortKey="Kruse, Torben A" sort="Kruse, Torben A" uniqKey="Kruse T" first="Torben A." last="Kruse">Torben A. Kruse</name><affiliation><nlm:aff id="A14">Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name><affiliation><nlm:aff id="A18">Section of Genetic Oncology, University Hospital of Pisa, Pisa, Italy</nlm:aff></affiliation></author><author><name sortKey="Von Wachenfeldt, Anna" sort="Von Wachenfeldt, Anna" uniqKey="Von Wachenfeldt A" first="Anna" last="Von Wachenfeldt">Anna Von Wachenfeldt</name><affiliation><nlm:aff id="A19">Department of Oncology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Barbany Bustinza, Gisela" sort="Barbany Bustinza, Gisela" uniqKey="Barbany Bustinza G" first="Gisela" last="Barbany-Bustinza">Gisela Barbany-Bustinza</name><affiliation><nlm:aff id="A20">Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Loman, Niklas" sort="Loman, Niklas" uniqKey="Loman N" first="Niklas" last="Loman">Niklas Loman</name><affiliation><nlm:aff id="A21">Department of Oncology, Lund University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Soller, Maria" sort="Soller, Maria" uniqKey="Soller M" first="Maria" last="Soller">Maria Soller</name><affiliation><nlm:aff id="A22">Department of Clinical Genetics. Lund University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name><affiliation><nlm:aff id="A23">Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Karlsson, Per" sort="Karlsson, Per" uniqKey="Karlsson P" first="Per" last="Karlsson">Per Karlsson</name><affiliation><nlm:aff id="A24">Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation><nlm:aff id="A25">Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name><affiliation><nlm:aff id="A26">Department of Biostatistics and Epidemiology, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name><affiliation><nlm:aff id="A25">Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Ania" sort="Jakubowska, Ania" uniqKey="Jakubowska A" first="Ania" last="Jakubowska">Ania Jakubowska</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Zlowocka, El Bieta" sort="Zlowocka, El Bieta" uniqKey="Zlowocka E" first="El Bieta" last="Złowocka">El Bieta Złowocka</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Byrski, Tomasz" sort="Byrski, Tomasz" uniqKey="Byrski T" first="Tomasz" last="Byrski">Tomasz Byrski</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="G Rski, Bohdan" sort="G Rski, Bohdan" uniqKey="G Rski B" first="Bohdan" last="G Rski">Bohdan G Rski</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><nlm:aff id="A29">Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, and Spanish Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Duran, Mercedes" sort="Duran, Mercedes" uniqKey="Duran M" first="Mercedes" last="Durán">Mercedes Durán</name><affiliation><nlm:aff id="A30">Institute of Biology and Molecular Genetics. Universidad de Valladolid (IBGM-UVA), Valladolid, Spain</nlm:aff></affiliation></author><author><name sortKey="Tejada, Maria Isabel" sort="Tejada, Maria Isabel" uniqKey="Tejada M" first="María Isabel" last="Tejada">María Isabel Tejada</name><affiliation><nlm:aff id="A31">Molecular Genetics Laboratory (Department of Biochemistry), Cruces Hospital Barakaldo, Bizkaia, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A32">Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, and Spanish Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A33">Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name><affiliation><nlm:aff id="A34">Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Os, Theo A" sort="Van Os, Theo A" uniqKey="Van Os T" first="Theo A." last="Van Os">Theo A. Van Os</name><affiliation><nlm:aff id="A35">Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Leeuwen, Flora E" sort="Van Leeuwen, Flora E" uniqKey="Van Leeuwen F" first="Flora E." last="Van Leeuwen">Flora E. Van Leeuwen</name><affiliation><nlm:aff id="A36">Department of Epidemiology. Head, Division of Psychosocial Research & Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne E J" sort="Meijers Heijboer, Hanne E J" uniqKey="Meijers Heijboer H" first="Hanne E. J." last="Meijers-Heijboer">Hanne E. J. Meijers-Heijboer</name><affiliation><nlm:aff id="A37">Department of Clinical Genetics, VU Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wijnen, Juul" sort="Wijnen, Juul" uniqKey="Wijnen J" first="Juul" last="Wijnen">Juul Wijnen</name><affiliation><nlm:aff id="A38">Department of Human Genetics & Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Blok, Marinus J" sort="Blok, Marinus J" uniqKey="Blok M" first="Marinus J." last="Blok">Marinus J. Blok</name><affiliation><nlm:aff id="A39">Department of Genetics and Cell Biology, University Medical Center, Maastricht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kets, Marleen" sort="Kets, Marleen" uniqKey="Kets M" first="Marleen" last="Kets">Marleen Kets</name><affiliation><nlm:aff id="A40">Hereditary Cancer Clinic, Radboud University Nijmegen Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="A41">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Oldenburg, Rogier A" sort="Oldenburg, Rogier A" uniqKey="Oldenburg R" first="Rogier A." last="Oldenburg">Rogier A. Oldenburg</name><affiliation><nlm:aff id="A42">Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ausems, Margreet G E M" sort="Ausems, Margreet G E M" uniqKey="Ausems M" first="Margreet G. E. M." last="Ausems">Margreet G. E. M. Ausems</name><affiliation><nlm:aff id="A43">Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ellis, Steve D" sort="Ellis, Steve D" uniqKey="Ellis S" first="Steve D." last="Ellis">Steve D. Ellis</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Fineberg, Elena" sort="Fineberg, Elena" uniqKey="Fineberg E" first="Elena" last="Fineberg">Elena Fineberg</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name><affiliation><nlm:aff id="A44">Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Jacobs, Chris" sort="Jacobs, Chris" uniqKey="Jacobs C" first="Chris" last="Jacobs">Chris Jacobs</name><affiliation><nlm:aff id="A45">Clinical Genetics, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation><nlm:aff id="A46">Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK</nlm:aff></affiliation></author><author><name sortKey="Adlard, Julian" sort="Adlard, Julian" uniqKey="Adlard J" first="Julian" last="Adlard">Julian Adlard</name><affiliation><nlm:aff id="A47">Yorkshire Regional Genetics Service, Leeds, UK</nlm:aff></affiliation></author><author><name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name><affiliation><nlm:aff id="A48">Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name><affiliation><nlm:aff id="A49">University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton UK</nlm:aff></affiliation></author><author><name sortKey="Cole, Trevor" sort="Cole, Trevor" uniqKey="Cole T" first="Trevor" last="Cole">Trevor Cole</name><affiliation><nlm:aff id="A50">West Midlands Regional Genetics Service, Birmingham Women’s Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK</nlm:aff></affiliation></author><author><name sortKey="Cook, Jackie" sort="Cook, Jackie" uniqKey="Cook J" first="Jackie" last="Cook">Jackie Cook</name><affiliation><nlm:aff id="A51">Sheffield Clinical Genetics Service, Sheffield Children’s Hospital, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Paterson, Joan" sort="Paterson, Joan" uniqKey="Paterson J" first="Joan" last="Paterson">Joan Paterson</name><affiliation><nlm:aff id="A52">Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Brewer, Carole" sort="Brewer, Carole" uniqKey="Brewer C" first="Carole" last="Brewer">Carole Brewer</name><affiliation><nlm:aff id="A53">Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Douglas, Fiona" sort="Douglas, Fiona" uniqKey="Douglas F" first="Fiona" last="Douglas">Fiona Douglas</name><affiliation><nlm:aff id="A54">Institute of Genetic Medicine, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK</nlm:aff></affiliation></author><author><name sortKey="Hodgson, Shirley V" sort="Hodgson, Shirley V" uniqKey="Hodgson S" first="Shirley V." last="Hodgson">Shirley V. Hodgson</name><affiliation><nlm:aff id="A55">Medical Genetics Unit, St George's, University of London, UK</nlm:aff></affiliation></author><author><name sortKey="Morrison, Patrick J" sort="Morrison, Patrick J" uniqKey="Morrison P" first="Patrick J." last="Morrison">Patrick J. Morrison</name><affiliation><nlm:aff id="A56">Northern Ireland Regional Genetics Centre, Belfast Health and Social Care Trust, and Department of Medical Genetics, Queens University Belfast, Belfast UK</nlm:aff></affiliation></author><author><name sortKey="Walker, Lisa" sort="Walker, Lisa" uniqKey="Walker L" first="Lisa" last="Walker">Lisa Walker</name><affiliation><nlm:aff id="A57">Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Porteous, Mary E" sort="Porteous, Mary E" uniqKey="Porteous M" first="Mary E." last="Porteous">Mary E. Porteous</name><affiliation><nlm:aff id="A58">South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Kennedy, M John" sort="Kennedy, M John" uniqKey="Kennedy M" first="M. John" last="Kennedy">M. John Kennedy</name><affiliation><nlm:aff id="A59">Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Side, Lucy E" sort="Side, Lucy E" uniqKey="Side L" first="Lucy E." last="Side">Lucy E. Side</name><affiliation><nlm:aff id="A60">North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Bove, Betsy" sort="Bove, Betsy" uniqKey="Bove B" first="Betsy" last="Bove">Betsy Bove</name><affiliation><nlm:aff id="A61">Clinical Molecular Genetics Laboratory, Fox Chase Cancer Center, Philadelphia, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="A62">Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA</nlm:aff></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation><nlm:aff id="A63">GEMO Study Collaborators: Cancer Genetics Network “Groupe Génétique et Cancer”, Fédération Nationale des Centres de Lutte Contre le Cancer, France</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Service de Génétique Oncologique, Institut Curie, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Unité INSERM U830, Institut Curie, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Université Paris Descartes, Faculté de Médecine, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Fassy Colcombet, Marion" sort="Fassy Colcombet, Marion" uniqKey="Fassy Colcombet M" first="Marion" last="Fassy-Colcombet">Marion Fassy-Colcombet</name><affiliation><nlm:aff id="A66">Université Paris Descartes, Faculté de Médecine, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Castera, Laurent" sort="Castera, Laurent" uniqKey="Castera L" first="Laurent" last="Castera">Laurent Castera</name><affiliation><nlm:aff id="A66">Université Paris Descartes, Faculté de Médecine, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Cornelis, Francois" sort="Cornelis, Francois" uniqKey="Cornelis F" first="François" last="Cornelis">François Cornelis</name><affiliation><nlm:aff id="A67">Genetic Unit, Avicenne Hospital, Assitance Publique-Hôpitaux de Paris, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Sud-Francilien Hospital, Evry-Corbeil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A69">University Hospital, Clermont-Ferrand, France</nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="A9">INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Leone, Melanie" sort="Leone, Melanie" uniqKey="Leone M" first="Mélanie" last="Léoné">Mélanie Léoné</name><affiliation><nlm:aff id="A8">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon / Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Boutry Kryza, Nadia" sort="Boutry Kryza, Nadia" uniqKey="Boutry Kryza N" first="Nadia" last="Boutry-Kryza">Nadia Boutry-Kryza</name><affiliation><nlm:aff id="A8">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon / Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Bressac De Paillerets, Brigitte" sort="Bressac De Paillerets, Brigitte" uniqKey="Bressac De Paillerets B" first="Brigitte" last="Bressac-De Paillerets">Brigitte Bressac-De Paillerets</name><affiliation><nlm:aff id="A70">Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Caron, Olivier" sort="Caron, Olivier" uniqKey="Caron O" first="Olivier" last="Caron">Olivier Caron</name><affiliation><nlm:aff id="A71">Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Pujol, Pascal" sort="Pujol, Pascal" uniqKey="Pujol P" first="Pascal" last="Pujol">Pascal Pujol</name><affiliation><nlm:aff id="A72">Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Coupier, Isabelle" sort="Coupier, Isabelle" uniqKey="Coupier I" first="Isabelle" last="Coupier">Isabelle Coupier</name><affiliation><nlm:aff id="A72">Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Delnatte, Capucine" sort="Delnatte, Capucine" uniqKey="Delnatte C" first="Capucine" last="Delnatte">Capucine Delnatte</name><affiliation><nlm:aff id="A73">Service Oncologie Médicale, Centre René Gauducheau, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Akloul, Linda" sort="Akloul, Linda" uniqKey="Akloul L" first="Linda" last="Akloul">Linda Akloul</name><affiliation><nlm:aff id="A73">Service Oncologie Médicale, Centre René Gauducheau, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Lynch, Henry T" sort="Lynch, Henry T" uniqKey="Lynch H" first="Henry T." last="Lynch">Henry T. Lynch</name><affiliation><nlm:aff id="A74">Department of Preventive Medicine, Creighton University, Omaha, NE, USA</nlm:aff></affiliation></author><author><name sortKey="Snyder, Carrie L" sort="Snyder, Carrie L" uniqKey="Snyder C" first="Carrie L." last="Snyder">Carrie L. Snyder</name><affiliation><nlm:aff id="A74">Department of Preventive Medicine, Creighton University, Omaha, NE, USA</nlm:aff></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name><affiliation><nlm:aff id="A75">Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA</nlm:aff></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name><affiliation><nlm:aff id="A76">Fox Chase Cancer Center, Philadelphia, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Terry, Marybeth" sort="Terry, Marybeth" uniqKey="Terry M" first="Marybeth" last="Terry">Marybeth Terry</name><affiliation><nlm:aff id="A77">Department of Epidemiology, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Chung, Wendy K" sort="Chung, Wendy K" uniqKey="Chung W" first="Wendy K." last="Chung">Wendy K. Chung</name><affiliation><nlm:aff id="A77">Department of Epidemiology, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="A78">Department of Epidemiology, Cancer Prevention Institute of California, Fremont, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation><nlm:aff id="A79">Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A80">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A81">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><affiliation><nlm:aff id="A82">Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA</nlm:aff></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F." last="Singer">Christian F. Singer</name><affiliation><nlm:aff id="A83">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Rappaport, Christine" sort="Rappaport, Christine" uniqKey="Rappaport C" first="Christine" last="Rappaport">Christine Rappaport</name><affiliation><nlm:aff id="A83">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Tea, Muy Kheng M" sort="Tea, Muy Kheng M" uniqKey="Tea M" first="Muy-Kheng M." last="Tea">Muy-Kheng M. Tea</name><affiliation><nlm:aff id="A83">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Fink Retter, Anneliese" sort="Fink Retter, Anneliese" uniqKey="Fink Retter A" first="Anneliese" last="Fink-Retter">Anneliese Fink-Retter</name><affiliation><nlm:aff id="A83">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V. O." last="Hansen">Thomas V. O. Hansen</name><affiliation><nlm:aff id="A84">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Finn C" sort="Nielsen, Finn C" uniqKey="Nielsen F" first="Finn C." last="Nielsen">Finn C. Nielsen</name><affiliation><nlm:aff id="A84">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Arason, A Algeir" sort="Arason, A Algeir" uniqKey="Arason A" first="A Algeir" last="Arason">A Algeir Arason</name><affiliation><nlm:aff id="A85">Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation><nlm:aff id="A7">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Shah, Sohela" sort="Shah, Sohela" uniqKey="Shah S" first="Sohela" last="Shah">Sohela Shah</name><affiliation><nlm:aff id="A7">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Sarrel, Kara" sort="Sarrel, Kara" uniqKey="Sarrel K" first="Kara" last="Sarrel">Kara Sarrel</name><affiliation><nlm:aff id="A7">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Robson, Mark E" sort="Robson, Mark E" uniqKey="Robson M" first="Mark E." last="Robson">Mark E. Robson</name><affiliation><nlm:aff id="A7">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name><affiliation><nlm:aff id="A87">Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, 666 Elm St, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Phillips, Kelly" sort="Phillips, Kelly" uniqKey="Phillips K" first="Kelly" last="Phillips">Kelly Phillips</name><affiliation><nlm:aff id="A88">Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia and Department of Medicine, St Vincent’s Hospital, The University of Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Basil, Jack" sort="Basil, Jack" uniqKey="Basil J" first="Jack" last="Basil">Jack Basil</name><affiliation><nlm:aff id="A89">Good Samaritan Hospital, Department of Obstetrics and Gynecology, GOG affilitate</nlm:aff></affiliation></author><author><name sortKey="Rubinstein, Wendy S" sort="Rubinstein, Wendy S" uniqKey="Rubinstein W" first="Wendy S." last="Rubinstein">Wendy S. Rubinstein</name><affiliation><nlm:aff id="A90">Center for Medical Genetics, NorthShore University Health System, Evanston, IL, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Boggess, John" sort="Boggess, John" uniqKey="Boggess J" first="John" last="Boggess">John Boggess</name><affiliation><nlm:aff id="A92">University of North Carolina, Chapel Hill, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Wakeley, Katie" sort="Wakeley, Katie" uniqKey="Wakeley K" first="Katie" last="Wakeley">Katie Wakeley</name><affiliation><nlm:aff id="A93">Dana-Farber/Brigham and Women's Cancer Center in clinical affiliation with South Shore Hospital, South Weymouth, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Ewart Toland, Amanda" sort="Ewart Toland, Amanda" uniqKey="Ewart Toland A" first="Amanda" last="Ewart-Toland">Amanda Ewart-Toland</name><affiliation><nlm:aff id="A94">Departments of Molecular Virology, Immunology & Medical Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation><nlm:aff id="A95">Istituto Oncologico Veneto IOV - IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Agata, Simona" sort="Agata, Simona" uniqKey="Agata S" first="Simona" last="Agata">Simona Agata</name><affiliation><nlm:aff id="A95">Istituto Oncologico Veneto IOV - IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N." last="Imyanitov">Evgeny N. Imyanitov</name><affiliation><nlm:aff id="A96">Laboratory of Molecular Oncology, N.N. Petrov Institute of Oncology, St.-Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation><nlm:aff id="A97">Fisher Center for Familial Cancer Research, Lombardi Comprehensive Cancer Center, Georgetown University, Washington D.C., USA</nlm:aff></affiliation></author><author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name><affiliation><nlm:aff id="A98">Dept. of Molecular and Regenerative medicine, Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Santariskiu st. 2, Vilnius, Lithuania</nlm:aff></affiliation></author><author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name><affiliation><nlm:aff id="A99">Molecular Diagnostic Unit, Hereditari Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name><affiliation><nlm:aff id="A100">Genetic Counseling Unit, Hereditari Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Feliubadalo, Lidia" sort="Feliubadalo, Lidia" uniqKey="Feliubadalo L" first="Lidia" last="Feliubadalo">Lidia Feliubadalo</name><affiliation><nlm:aff id="A99">Molecular Diagnostic Unit, Hereditari Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Brunet, Joan" sort="Brunet, Joan" uniqKey="Brunet J" first="Joan" last="Brunet">Joan Brunet</name><affiliation><nlm:aff id="A100">Genetic Counseling Unit, Hereditari Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A" last="Gayther">Simon A. Gayther</name><affiliation><nlm:aff id="A101">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul Pd" sort="Pharoah, Paul Pd" uniqKey="Pharoah P" first="Paul Pd" last="Pharoah">Paul Pd Pharoah</name><affiliation><nlm:aff id="A102">Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Odunsi, Kunle O" sort="Odunsi, Kunle O" uniqKey="Odunsi K" first="Kunle O." last="Odunsi">Kunle O. Odunsi</name><affiliation><nlm:aff id="A103">Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y." last="Karlan">Beth Y. Karlan</name><affiliation><nlm:aff id="A104">Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Walsh, Christine S" sort="Walsh, Christine S" uniqKey="Walsh C" first="Christine S." last="Walsh">Christine S. Walsh</name><affiliation><nlm:aff id="A104">Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation><nlm:aff id="A105">Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo Hwang" last="Teo">Soo Hwang Teo</name><affiliation><nlm:aff id="A105">Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><affiliation><nlm:aff id="A107">UCLA School of Public Health, Department of Health Services, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Beattie, Mary S" sort="Beattie, Mary S" uniqKey="Beattie M" first="Mary S." last="Beattie">Mary S. Beattie</name><affiliation><nlm:aff id="A108">Department of Medicine, Epidemiology and Biostatistics, University of California, San Francisco, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J." last="Van Rensburg">Elizabeth J. Van Rensburg</name><affiliation><nlm:aff id="A109">Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, South Africa</nlm:aff></affiliation></author><author><name sortKey="Dorfling, Cecelia M" sort="Dorfling, Cecelia M" uniqKey="Dorfling C" first="Cecelia M." last="Dorfling">Cecelia M. Dorfling</name><affiliation><nlm:aff id="A109">Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, South Africa</nlm:aff></affiliation></author><author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name><affiliation><nlm:aff id="A110">Molecular Medicine and Genetics Program. Vall d'Hebron University Hospital. Oncogenetics Laboratory. Vall d'Hebron Institute of Oncology (VHIO). Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name><affiliation><nlm:aff id="A111">Hong Kong Hereditary Breast Cancer Family Registry and Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A112">Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Wappenschmidt, Barbara" sort="Wappenschmidt, Barbara" uniqKey="Wappenschmidt B" first="Barbara" last="Wappenschmidt">Barbara Wappenschmidt</name><affiliation><nlm:aff id="A112">Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation><nlm:aff id="A113">Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A114">Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Ditsch, Nina" sort="Ditsch, Nina" uniqKey="Ditsch N" first="Nina" last="Ditsch">Nina Ditsch</name><affiliation><nlm:aff id="A115">Department of Gynaecology and Obstetrics, Ludwig-Maximilian University Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation><nlm:aff id="A116">Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Heidemann, Simone" sort="Heidemann, Simone" uniqKey="Heidemann S" first="Simone" last="Heidemann">Simone Heidemann</name><affiliation><nlm:aff id="A117">Institute of Human Genetics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation><nlm:aff id="A118">Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University, Düsseldorf, Germany</nlm:aff></affiliation></author><author><name sortKey="Preisler Adams, Sabine" sort="Preisler Adams, Sabine" uniqKey="Preisler Adams S" first="Sabine" last="Preisler-Adams">Sabine Preisler-Adams</name><affiliation><nlm:aff id="A119">Institute of Human Genetics, University of Münster, Münster, Germany</nlm:aff></affiliation></author><author><name sortKey="Gadzicki, Dorothea" sort="Gadzicki, Dorothea" uniqKey="Gadzicki D" first="Dorothea" last="Gadzicki">Dorothea Gadzicki</name><affiliation><nlm:aff id="A120">Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Varon Mateeva, Raymonda" sort="Varon Mateeva, Raymonda" uniqKey="Varon Mateeva R" first="Raymonda" last="Varon-Mateeva">Raymonda Varon-Mateeva</name><affiliation><nlm:aff id="A121">Institute of Human Genetics, Campus Virchov Klinikum, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Deissler, Helmut" sort="Deissler, Helmut" uniqKey="Deissler H" first="Helmut" last="Deissler">Helmut Deissler</name><affiliation><nlm:aff id="A122">Department of Gynaecology and Obstetrics, University Hospital Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Gehrig, Andrea" sort="Gehrig, Andrea" uniqKey="Gehrig A" first="Andrea" last="Gehrig">Andrea Gehrig</name><affiliation><nlm:aff id="A123">Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation><nlm:aff id="A124">Institute of Human Genetics, Division of Molecular Genetics, University Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kast, Karin" sort="Kast, Karin" uniqKey="Kast K" first="Karin" last="Kast">Karin Kast</name><affiliation><nlm:aff id="A125">Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Fiebig, Britta" sort="Fiebig, Britta" uniqKey="Fiebig B" first="Britta" last="Fiebig">Britta Fiebig</name><affiliation><nlm:aff id="A126">Institute of Human Genetics, University Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Heinritz, Wolfram" sort="Heinritz, Wolfram" uniqKey="Heinritz W" first="Wolfram" last="Heinritz">Wolfram Heinritz</name><affiliation><nlm:aff id="A127">Institute of Human Genetics, University Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation><nlm:aff id="A128">Molecular Oncology Laboratory, Hospital Clinico San Carlos. Martin Lagos s/n, 28040 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation><nlm:aff id="A128">Molecular Oncology Laboratory, Hospital Clinico San Carlos. Martin Lagos s/n, 28040 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="A129">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A129">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Tischkowitz, Marc D" sort="Tischkowitz, Marc D" uniqKey="Tischkowitz M" first="Marc D." last="Tischkowitz">Marc D. Tischkowitz</name><affiliation><nlm:aff id="A130">Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A131">Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation><nlm:aff id="A6">Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A132">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA USA</nlm:aff></affiliation></author><author><name sortKey="Ding, Yuan Chun" sort="Ding, Yuan Chun" uniqKey="Ding Y" first="Yuan Chun" last="Ding">Yuan Chun Ding</name><affiliation><nlm:aff id="A132">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA USA</nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><affiliation><nlm:aff id="A133">Department of Medical Genetics, Mayo Clinic Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Fredericksen, Zachary" sort="Fredericksen, Zachary" uniqKey="Fredericksen Z" first="Zachary" last="Fredericksen">Zachary Fredericksen</name><affiliation><nlm:aff id="A134">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V. Shane" last="Pankratz">V. Shane Pankratz</name><affiliation><nlm:aff id="A134">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A135">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A136">Unit of Medical Genetics, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation><nlm:aff id="A136">Unit of Medical Genetics, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Zaffaroni, Daniela" sort="Zaffaroni, Daniela" uniqKey="Zaffaroni D" first="Daniela" last="Zaffaroni">Daniela Zaffaroni</name><affiliation><nlm:aff id="A136">Unit of Medical Genetics, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation><nlm:aff id="A137">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bernard, Loris" sort="Bernard, Loris" uniqKey="Bernard L" first="Loris" last="Bernard">Loris Bernard</name><affiliation><nlm:aff id="A138">Department of Experimental Oncology, Istituto Europeo di Oncologia, and Consortium for Genomics Technology (Cogentech), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Viel, Alessandra" sort="Viel, Alessandra" uniqKey="Viel A" first="Alessandra" last="Viel">Alessandra Viel</name><affiliation><nlm:aff id="A139">Unit of Experimental Oncology 1, Centro di Riferimento Oncologico, IRCCS, Aviano (PN), Italy</nlm:aff></affiliation></author><author><name sortKey="Giannini, Giuseppe" sort="Giannini, Giuseppe" uniqKey="Giannini G" first="Giuseppe" last="Giannini">Giuseppe Giannini</name><affiliation><nlm:aff id="A140">Department of Experimental Medicine, University La Sapienza, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Varesco, Liliana" sort="Varesco, Liliana" uniqKey="Varesco L" first="Liliana" last="Varesco">Liliana Varesco</name><affiliation><nlm:aff id="A141">Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, Istituto Nazionale per la Ricerca sul Cancro (IST), Genoa, Italy</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A135">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation><nlm:aff id="A142">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, NCI, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name><affiliation><nlm:aff id="A142">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, NCI, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A6">Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="A7">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A5">Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City (Quebec), Canada</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22351618</idno><idno type="pmc">3319317</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319317</idno><idno type="RBID">PMC:3319317</idno><idno type="doi">10.1158/1055-9965.EPI-11-0888</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002087</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002087</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common variants at the 19p13.1 and <italic>ZNF365</italic> loci are associated with ER subtypes of breast cancer and ovarian cancer risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers</title><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="A2">Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J." last="Ramus">Susan J. Ramus</name><affiliation><nlm:aff id="A4">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B." last="Kuchenbaecker">Karoline B. Kuchenbaecker</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="A5">Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City (Quebec), Canada</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A6">Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation><nlm:aff id="A6">Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Kirchhoff, Tomas" sort="Kirchhoff, Tomas" uniqKey="Kirchhoff T" first="Tomas" last="Kirchhoff">Tomas Kirchhoff</name><affiliation><nlm:aff id="A7">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lee, Andrew" sort="Lee, Andrew" uniqKey="Lee A" first="Andrew" last="Lee">Andrew Lee</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><nlm:aff id="A6">Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><nlm:aff id="A8">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon / Centre Léon Bérard, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A9">INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A10">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Cancer Care Ontario, Department of Molecular Genetics, University of Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Cancer Care Ontario, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Ontario Cancer Genetics Network: Cancer Care Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name><affiliation><nlm:aff id="A11">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Cancer Care Ontario, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="A11">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Cancer Care Ontario, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="A14">Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation><nlm:aff id="A15">Department of Clincial Genetics, Rigshospitalet, København, Denmark</nlm:aff></affiliation></author><author><name sortKey="Jensen, Uffe Birk" sort="Jensen, Uffe Birk" uniqKey="Jensen U" first="Uffe Birk" last="Jensen">Uffe Birk Jensen</name><affiliation><nlm:aff id="A16">Department of Clinical Genetics, Skejby Hospital, Århus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Skytte, Anne Bine" sort="Skytte, Anne Bine" uniqKey="Skytte A" first="Anne-Bine" last="Skytte">Anne-Bine Skytte</name><affiliation><nlm:aff id="A17">Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</nlm:aff></affiliation></author><author><name sortKey="Kruse, Torben A" sort="Kruse, Torben A" uniqKey="Kruse T" first="Torben A." last="Kruse">Torben A. Kruse</name><affiliation><nlm:aff id="A14">Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name><affiliation><nlm:aff id="A18">Section of Genetic Oncology, University Hospital of Pisa, Pisa, Italy</nlm:aff></affiliation></author><author><name sortKey="Von Wachenfeldt, Anna" sort="Von Wachenfeldt, Anna" uniqKey="Von Wachenfeldt A" first="Anna" last="Von Wachenfeldt">Anna Von Wachenfeldt</name><affiliation><nlm:aff id="A19">Department of Oncology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Barbany Bustinza, Gisela" sort="Barbany Bustinza, Gisela" uniqKey="Barbany Bustinza G" first="Gisela" last="Barbany-Bustinza">Gisela Barbany-Bustinza</name><affiliation><nlm:aff id="A20">Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Loman, Niklas" sort="Loman, Niklas" uniqKey="Loman N" first="Niklas" last="Loman">Niklas Loman</name><affiliation><nlm:aff id="A21">Department of Oncology, Lund University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Soller, Maria" sort="Soller, Maria" uniqKey="Soller M" first="Maria" last="Soller">Maria Soller</name><affiliation><nlm:aff id="A22">Department of Clinical Genetics. Lund University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name><affiliation><nlm:aff id="A23">Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Karlsson, Per" sort="Karlsson, Per" uniqKey="Karlsson P" first="Per" last="Karlsson">Per Karlsson</name><affiliation><nlm:aff id="A24">Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation><nlm:aff id="A25">Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name><affiliation><nlm:aff id="A26">Department of Biostatistics and Epidemiology, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name><affiliation><nlm:aff id="A25">Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Ania" sort="Jakubowska, Ania" uniqKey="Jakubowska A" first="Ania" last="Jakubowska">Ania Jakubowska</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Zlowocka, El Bieta" sort="Zlowocka, El Bieta" uniqKey="Zlowocka E" first="El Bieta" last="Złowocka">El Bieta Złowocka</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Byrski, Tomasz" sort="Byrski, Tomasz" uniqKey="Byrski T" first="Tomasz" last="Byrski">Tomasz Byrski</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="G Rski, Bohdan" sort="G Rski, Bohdan" uniqKey="G Rski B" first="Bohdan" last="G Rski">Bohdan G Rski</name><affiliation><nlm:aff id="A27">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><nlm:aff id="A29">Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, and Spanish Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Duran, Mercedes" sort="Duran, Mercedes" uniqKey="Duran M" first="Mercedes" last="Durán">Mercedes Durán</name><affiliation><nlm:aff id="A30">Institute of Biology and Molecular Genetics. Universidad de Valladolid (IBGM-UVA), Valladolid, Spain</nlm:aff></affiliation></author><author><name sortKey="Tejada, Maria Isabel" sort="Tejada, Maria Isabel" uniqKey="Tejada M" first="María Isabel" last="Tejada">María Isabel Tejada</name><affiliation><nlm:aff id="A31">Molecular Genetics Laboratory (Department of Biochemistry), Cruces Hospital Barakaldo, Bizkaia, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A32">Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, and Spanish Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A33">Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name><affiliation><nlm:aff id="A34">Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Os, Theo A" sort="Van Os, Theo A" uniqKey="Van Os T" first="Theo A." last="Van Os">Theo A. Van Os</name><affiliation><nlm:aff id="A35">Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Leeuwen, Flora E" sort="Van Leeuwen, Flora E" uniqKey="Van Leeuwen F" first="Flora E." last="Van Leeuwen">Flora E. Van Leeuwen</name><affiliation><nlm:aff id="A36">Department of Epidemiology. Head, Division of Psychosocial Research & Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne E J" sort="Meijers Heijboer, Hanne E J" uniqKey="Meijers Heijboer H" first="Hanne E. J." last="Meijers-Heijboer">Hanne E. J. Meijers-Heijboer</name><affiliation><nlm:aff id="A37">Department of Clinical Genetics, VU Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wijnen, Juul" sort="Wijnen, Juul" uniqKey="Wijnen J" first="Juul" last="Wijnen">Juul Wijnen</name><affiliation><nlm:aff id="A38">Department of Human Genetics & Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Blok, Marinus J" sort="Blok, Marinus J" uniqKey="Blok M" first="Marinus J." last="Blok">Marinus J. Blok</name><affiliation><nlm:aff id="A39">Department of Genetics and Cell Biology, University Medical Center, Maastricht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kets, Marleen" sort="Kets, Marleen" uniqKey="Kets M" first="Marleen" last="Kets">Marleen Kets</name><affiliation><nlm:aff id="A40">Hereditary Cancer Clinic, Radboud University Nijmegen Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="A41">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Oldenburg, Rogier A" sort="Oldenburg, Rogier A" uniqKey="Oldenburg R" first="Rogier A." last="Oldenburg">Rogier A. Oldenburg</name><affiliation><nlm:aff id="A42">Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ausems, Margreet G E M" sort="Ausems, Margreet G E M" uniqKey="Ausems M" first="Margreet G. E. M." last="Ausems">Margreet G. E. M. Ausems</name><affiliation><nlm:aff id="A43">Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ellis, Steve D" sort="Ellis, Steve D" uniqKey="Ellis S" first="Steve D." last="Ellis">Steve D. Ellis</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Fineberg, Elena" sort="Fineberg, Elena" uniqKey="Fineberg E" first="Elena" last="Fineberg">Elena Fineberg</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name><affiliation><nlm:aff id="A44">Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Jacobs, Chris" sort="Jacobs, Chris" uniqKey="Jacobs C" first="Chris" last="Jacobs">Chris Jacobs</name><affiliation><nlm:aff id="A45">Clinical Genetics, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation><nlm:aff id="A46">Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK</nlm:aff></affiliation></author><author><name sortKey="Adlard, Julian" sort="Adlard, Julian" uniqKey="Adlard J" first="Julian" last="Adlard">Julian Adlard</name><affiliation><nlm:aff id="A47">Yorkshire Regional Genetics Service, Leeds, UK</nlm:aff></affiliation></author><author><name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name><affiliation><nlm:aff id="A48">Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name><affiliation><nlm:aff id="A49">University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton UK</nlm:aff></affiliation></author><author><name sortKey="Cole, Trevor" sort="Cole, Trevor" uniqKey="Cole T" first="Trevor" last="Cole">Trevor Cole</name><affiliation><nlm:aff id="A50">West Midlands Regional Genetics Service, Birmingham Women’s Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK</nlm:aff></affiliation></author><author><name sortKey="Cook, Jackie" sort="Cook, Jackie" uniqKey="Cook J" first="Jackie" last="Cook">Jackie Cook</name><affiliation><nlm:aff id="A51">Sheffield Clinical Genetics Service, Sheffield Children’s Hospital, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Paterson, Joan" sort="Paterson, Joan" uniqKey="Paterson J" first="Joan" last="Paterson">Joan Paterson</name><affiliation><nlm:aff id="A52">Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Brewer, Carole" sort="Brewer, Carole" uniqKey="Brewer C" first="Carole" last="Brewer">Carole Brewer</name><affiliation><nlm:aff id="A53">Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Douglas, Fiona" sort="Douglas, Fiona" uniqKey="Douglas F" first="Fiona" last="Douglas">Fiona Douglas</name><affiliation><nlm:aff id="A54">Institute of Genetic Medicine, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK</nlm:aff></affiliation></author><author><name sortKey="Hodgson, Shirley V" sort="Hodgson, Shirley V" uniqKey="Hodgson S" first="Shirley V." last="Hodgson">Shirley V. Hodgson</name><affiliation><nlm:aff id="A55">Medical Genetics Unit, St George's, University of London, UK</nlm:aff></affiliation></author><author><name sortKey="Morrison, Patrick J" sort="Morrison, Patrick J" uniqKey="Morrison P" first="Patrick J." last="Morrison">Patrick J. Morrison</name><affiliation><nlm:aff id="A56">Northern Ireland Regional Genetics Centre, Belfast Health and Social Care Trust, and Department of Medical Genetics, Queens University Belfast, Belfast UK</nlm:aff></affiliation></author><author><name sortKey="Walker, Lisa" sort="Walker, Lisa" uniqKey="Walker L" first="Lisa" last="Walker">Lisa Walker</name><affiliation><nlm:aff id="A57">Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Porteous, Mary E" sort="Porteous, Mary E" uniqKey="Porteous M" first="Mary E." last="Porteous">Mary E. Porteous</name><affiliation><nlm:aff id="A58">South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Kennedy, M John" sort="Kennedy, M John" uniqKey="Kennedy M" first="M. John" last="Kennedy">M. John Kennedy</name><affiliation><nlm:aff id="A59">Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Side, Lucy E" sort="Side, Lucy E" uniqKey="Side L" first="Lucy E." last="Side">Lucy E. Side</name><affiliation><nlm:aff id="A60">North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Bove, Betsy" sort="Bove, Betsy" uniqKey="Bove B" first="Betsy" last="Bove">Betsy Bove</name><affiliation><nlm:aff id="A61">Clinical Molecular Genetics Laboratory, Fox Chase Cancer Center, Philadelphia, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="A62">Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA</nlm:aff></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation><nlm:aff id="A63">GEMO Study Collaborators: Cancer Genetics Network “Groupe Génétique et Cancer”, Fédération Nationale des Centres de Lutte Contre le Cancer, France</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Service de Génétique Oncologique, Institut Curie, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Unité INSERM U830, Institut Curie, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Université Paris Descartes, Faculté de Médecine, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Fassy Colcombet, Marion" sort="Fassy Colcombet, Marion" uniqKey="Fassy Colcombet M" first="Marion" last="Fassy-Colcombet">Marion Fassy-Colcombet</name><affiliation><nlm:aff id="A66">Université Paris Descartes, Faculté de Médecine, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Castera, Laurent" sort="Castera, Laurent" uniqKey="Castera L" first="Laurent" last="Castera">Laurent Castera</name><affiliation><nlm:aff id="A66">Université Paris Descartes, Faculté de Médecine, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Cornelis, Francois" sort="Cornelis, Francois" uniqKey="Cornelis F" first="François" last="Cornelis">François Cornelis</name><affiliation><nlm:aff id="A67">Genetic Unit, Avicenne Hospital, Assitance Publique-Hôpitaux de Paris, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Sud-Francilien Hospital, Evry-Corbeil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A69">University Hospital, Clermont-Ferrand, France</nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="A9">INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Leone, Melanie" sort="Leone, Melanie" uniqKey="Leone M" first="Mélanie" last="Léoné">Mélanie Léoné</name><affiliation><nlm:aff id="A8">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon / Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Boutry Kryza, Nadia" sort="Boutry Kryza, Nadia" uniqKey="Boutry Kryza N" first="Nadia" last="Boutry-Kryza">Nadia Boutry-Kryza</name><affiliation><nlm:aff id="A8">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon / Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Bressac De Paillerets, Brigitte" sort="Bressac De Paillerets, Brigitte" uniqKey="Bressac De Paillerets B" first="Brigitte" last="Bressac-De Paillerets">Brigitte Bressac-De Paillerets</name><affiliation><nlm:aff id="A70">Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Caron, Olivier" sort="Caron, Olivier" uniqKey="Caron O" first="Olivier" last="Caron">Olivier Caron</name><affiliation><nlm:aff id="A71">Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Pujol, Pascal" sort="Pujol, Pascal" uniqKey="Pujol P" first="Pascal" last="Pujol">Pascal Pujol</name><affiliation><nlm:aff id="A72">Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Coupier, Isabelle" sort="Coupier, Isabelle" uniqKey="Coupier I" first="Isabelle" last="Coupier">Isabelle Coupier</name><affiliation><nlm:aff id="A72">Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Delnatte, Capucine" sort="Delnatte, Capucine" uniqKey="Delnatte C" first="Capucine" last="Delnatte">Capucine Delnatte</name><affiliation><nlm:aff id="A73">Service Oncologie Médicale, Centre René Gauducheau, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Akloul, Linda" sort="Akloul, Linda" uniqKey="Akloul L" first="Linda" last="Akloul">Linda Akloul</name><affiliation><nlm:aff id="A73">Service Oncologie Médicale, Centre René Gauducheau, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Lynch, Henry T" sort="Lynch, Henry T" uniqKey="Lynch H" first="Henry T." last="Lynch">Henry T. Lynch</name><affiliation><nlm:aff id="A74">Department of Preventive Medicine, Creighton University, Omaha, NE, USA</nlm:aff></affiliation></author><author><name sortKey="Snyder, Carrie L" sort="Snyder, Carrie L" uniqKey="Snyder C" first="Carrie L." last="Snyder">Carrie L. Snyder</name><affiliation><nlm:aff id="A74">Department of Preventive Medicine, Creighton University, Omaha, NE, USA</nlm:aff></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name><affiliation><nlm:aff id="A75">Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA</nlm:aff></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name><affiliation><nlm:aff id="A76">Fox Chase Cancer Center, Philadelphia, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Terry, Marybeth" sort="Terry, Marybeth" uniqKey="Terry M" first="Marybeth" last="Terry">Marybeth Terry</name><affiliation><nlm:aff id="A77">Department of Epidemiology, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Chung, Wendy K" sort="Chung, Wendy K" uniqKey="Chung W" first="Wendy K." last="Chung">Wendy K. Chung</name><affiliation><nlm:aff id="A77">Department of Epidemiology, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="A78">Department of Epidemiology, Cancer Prevention Institute of California, Fremont, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation><nlm:aff id="A79">Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A80">Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A81">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><affiliation><nlm:aff id="A82">Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA</nlm:aff></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F." last="Singer">Christian F. Singer</name><affiliation><nlm:aff id="A83">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Rappaport, Christine" sort="Rappaport, Christine" uniqKey="Rappaport C" first="Christine" last="Rappaport">Christine Rappaport</name><affiliation><nlm:aff id="A83">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Tea, Muy Kheng M" sort="Tea, Muy Kheng M" uniqKey="Tea M" first="Muy-Kheng M." last="Tea">Muy-Kheng M. Tea</name><affiliation><nlm:aff id="A83">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Fink Retter, Anneliese" sort="Fink Retter, Anneliese" uniqKey="Fink Retter A" first="Anneliese" last="Fink-Retter">Anneliese Fink-Retter</name><affiliation><nlm:aff id="A83">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V. O." last="Hansen">Thomas V. O. Hansen</name><affiliation><nlm:aff id="A84">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Finn C" sort="Nielsen, Finn C" uniqKey="Nielsen F" first="Finn C." last="Nielsen">Finn C. Nielsen</name><affiliation><nlm:aff id="A84">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Arason, A Algeir" sort="Arason, A Algeir" uniqKey="Arason A" first="A Algeir" last="Arason">A Algeir Arason</name><affiliation><nlm:aff id="A85">Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation><nlm:aff id="A7">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Shah, Sohela" sort="Shah, Sohela" uniqKey="Shah S" first="Sohela" last="Shah">Sohela Shah</name><affiliation><nlm:aff id="A7">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Sarrel, Kara" sort="Sarrel, Kara" uniqKey="Sarrel K" first="Kara" last="Sarrel">Kara Sarrel</name><affiliation><nlm:aff id="A7">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Robson, Mark E" sort="Robson, Mark E" uniqKey="Robson M" first="Mark E." last="Robson">Mark E. Robson</name><affiliation><nlm:aff id="A7">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name><affiliation><nlm:aff id="A87">Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, 666 Elm St, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Phillips, Kelly" sort="Phillips, Kelly" uniqKey="Phillips K" first="Kelly" last="Phillips">Kelly Phillips</name><affiliation><nlm:aff id="A88">Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia and Department of Medicine, St Vincent’s Hospital, The University of Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Basil, Jack" sort="Basil, Jack" uniqKey="Basil J" first="Jack" last="Basil">Jack Basil</name><affiliation><nlm:aff id="A89">Good Samaritan Hospital, Department of Obstetrics and Gynecology, GOG affilitate</nlm:aff></affiliation></author><author><name sortKey="Rubinstein, Wendy S" sort="Rubinstein, Wendy S" uniqKey="Rubinstein W" first="Wendy S." last="Rubinstein">Wendy S. Rubinstein</name><affiliation><nlm:aff id="A90">Center for Medical Genetics, NorthShore University Health System, Evanston, IL, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Boggess, John" sort="Boggess, John" uniqKey="Boggess J" first="John" last="Boggess">John Boggess</name><affiliation><nlm:aff id="A92">University of North Carolina, Chapel Hill, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Wakeley, Katie" sort="Wakeley, Katie" uniqKey="Wakeley K" first="Katie" last="Wakeley">Katie Wakeley</name><affiliation><nlm:aff id="A93">Dana-Farber/Brigham and Women's Cancer Center in clinical affiliation with South Shore Hospital, South Weymouth, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Ewart Toland, Amanda" sort="Ewart Toland, Amanda" uniqKey="Ewart Toland A" first="Amanda" last="Ewart-Toland">Amanda Ewart-Toland</name><affiliation><nlm:aff id="A94">Departments of Molecular Virology, Immunology & Medical Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation><nlm:aff id="A95">Istituto Oncologico Veneto IOV - IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Agata, Simona" sort="Agata, Simona" uniqKey="Agata S" first="Simona" last="Agata">Simona Agata</name><affiliation><nlm:aff id="A95">Istituto Oncologico Veneto IOV - IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N." last="Imyanitov">Evgeny N. Imyanitov</name><affiliation><nlm:aff id="A96">Laboratory of Molecular Oncology, N.N. Petrov Institute of Oncology, St.-Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation><nlm:aff id="A97">Fisher Center for Familial Cancer Research, Lombardi Comprehensive Cancer Center, Georgetown University, Washington D.C., USA</nlm:aff></affiliation></author><author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name><affiliation><nlm:aff id="A98">Dept. of Molecular and Regenerative medicine, Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Santariskiu st. 2, Vilnius, Lithuania</nlm:aff></affiliation></author><author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name><affiliation><nlm:aff id="A99">Molecular Diagnostic Unit, Hereditari Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name><affiliation><nlm:aff id="A100">Genetic Counseling Unit, Hereditari Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Feliubadalo, Lidia" sort="Feliubadalo, Lidia" uniqKey="Feliubadalo L" first="Lidia" last="Feliubadalo">Lidia Feliubadalo</name><affiliation><nlm:aff id="A99">Molecular Diagnostic Unit, Hereditari Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Brunet, Joan" sort="Brunet, Joan" uniqKey="Brunet J" first="Joan" last="Brunet">Joan Brunet</name><affiliation><nlm:aff id="A100">Genetic Counseling Unit, Hereditari Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A" last="Gayther">Simon A. Gayther</name><affiliation><nlm:aff id="A101">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul Pd" sort="Pharoah, Paul Pd" uniqKey="Pharoah P" first="Paul Pd" last="Pharoah">Paul Pd Pharoah</name><affiliation><nlm:aff id="A102">Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Odunsi, Kunle O" sort="Odunsi, Kunle O" uniqKey="Odunsi K" first="Kunle O." last="Odunsi">Kunle O. Odunsi</name><affiliation><nlm:aff id="A103">Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y." last="Karlan">Beth Y. Karlan</name><affiliation><nlm:aff id="A104">Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Walsh, Christine S" sort="Walsh, Christine S" uniqKey="Walsh C" first="Christine S." last="Walsh">Christine S. Walsh</name><affiliation><nlm:aff id="A104">Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation><nlm:aff id="A105">Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo Hwang" last="Teo">Soo Hwang Teo</name><affiliation><nlm:aff id="A105">Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><affiliation><nlm:aff id="A107">UCLA School of Public Health, Department of Health Services, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Beattie, Mary S" sort="Beattie, Mary S" uniqKey="Beattie M" first="Mary S." last="Beattie">Mary S. Beattie</name><affiliation><nlm:aff id="A108">Department of Medicine, Epidemiology and Biostatistics, University of California, San Francisco, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J." last="Van Rensburg">Elizabeth J. Van Rensburg</name><affiliation><nlm:aff id="A109">Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, South Africa</nlm:aff></affiliation></author><author><name sortKey="Dorfling, Cecelia M" sort="Dorfling, Cecelia M" uniqKey="Dorfling C" first="Cecelia M." last="Dorfling">Cecelia M. Dorfling</name><affiliation><nlm:aff id="A109">Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, South Africa</nlm:aff></affiliation></author><author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name><affiliation><nlm:aff id="A110">Molecular Medicine and Genetics Program. Vall d'Hebron University Hospital. Oncogenetics Laboratory. Vall d'Hebron Institute of Oncology (VHIO). Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name><affiliation><nlm:aff id="A111">Hong Kong Hereditary Breast Cancer Family Registry and Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A112">Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Wappenschmidt, Barbara" sort="Wappenschmidt, Barbara" uniqKey="Wappenschmidt B" first="Barbara" last="Wappenschmidt">Barbara Wappenschmidt</name><affiliation><nlm:aff id="A112">Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation><nlm:aff id="A113">Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A114">Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Ditsch, Nina" sort="Ditsch, Nina" uniqKey="Ditsch N" first="Nina" last="Ditsch">Nina Ditsch</name><affiliation><nlm:aff id="A115">Department of Gynaecology and Obstetrics, Ludwig-Maximilian University Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation><nlm:aff id="A116">Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Heidemann, Simone" sort="Heidemann, Simone" uniqKey="Heidemann S" first="Simone" last="Heidemann">Simone Heidemann</name><affiliation><nlm:aff id="A117">Institute of Human Genetics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation><nlm:aff id="A118">Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University, Düsseldorf, Germany</nlm:aff></affiliation></author><author><name sortKey="Preisler Adams, Sabine" sort="Preisler Adams, Sabine" uniqKey="Preisler Adams S" first="Sabine" last="Preisler-Adams">Sabine Preisler-Adams</name><affiliation><nlm:aff id="A119">Institute of Human Genetics, University of Münster, Münster, Germany</nlm:aff></affiliation></author><author><name sortKey="Gadzicki, Dorothea" sort="Gadzicki, Dorothea" uniqKey="Gadzicki D" first="Dorothea" last="Gadzicki">Dorothea Gadzicki</name><affiliation><nlm:aff id="A120">Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Varon Mateeva, Raymonda" sort="Varon Mateeva, Raymonda" uniqKey="Varon Mateeva R" first="Raymonda" last="Varon-Mateeva">Raymonda Varon-Mateeva</name><affiliation><nlm:aff id="A121">Institute of Human Genetics, Campus Virchov Klinikum, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Deissler, Helmut" sort="Deissler, Helmut" uniqKey="Deissler H" first="Helmut" last="Deissler">Helmut Deissler</name><affiliation><nlm:aff id="A122">Department of Gynaecology and Obstetrics, University Hospital Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Gehrig, Andrea" sort="Gehrig, Andrea" uniqKey="Gehrig A" first="Andrea" last="Gehrig">Andrea Gehrig</name><affiliation><nlm:aff id="A123">Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation><nlm:aff id="A124">Institute of Human Genetics, Division of Molecular Genetics, University Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kast, Karin" sort="Kast, Karin" uniqKey="Kast K" first="Karin" last="Kast">Karin Kast</name><affiliation><nlm:aff id="A125">Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Fiebig, Britta" sort="Fiebig, Britta" uniqKey="Fiebig B" first="Britta" last="Fiebig">Britta Fiebig</name><affiliation><nlm:aff id="A126">Institute of Human Genetics, University Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Heinritz, Wolfram" sort="Heinritz, Wolfram" uniqKey="Heinritz W" first="Wolfram" last="Heinritz">Wolfram Heinritz</name><affiliation><nlm:aff id="A127">Institute of Human Genetics, University Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation><nlm:aff id="A128">Molecular Oncology Laboratory, Hospital Clinico San Carlos. Martin Lagos s/n, 28040 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation><nlm:aff id="A128">Molecular Oncology Laboratory, Hospital Clinico San Carlos. Martin Lagos s/n, 28040 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="A129">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A129">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Tischkowitz, Marc D" sort="Tischkowitz, Marc D" uniqKey="Tischkowitz M" first="Marc D." last="Tischkowitz">Marc D. Tischkowitz</name><affiliation><nlm:aff id="A130">Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A131">Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation><nlm:aff id="A6">Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A132">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA USA</nlm:aff></affiliation></author><author><name sortKey="Ding, Yuan Chun" sort="Ding, Yuan Chun" uniqKey="Ding Y" first="Yuan Chun" last="Ding">Yuan Chun Ding</name><affiliation><nlm:aff id="A132">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA USA</nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><affiliation><nlm:aff id="A133">Department of Medical Genetics, Mayo Clinic Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Fredericksen, Zachary" sort="Fredericksen, Zachary" uniqKey="Fredericksen Z" first="Zachary" last="Fredericksen">Zachary Fredericksen</name><affiliation><nlm:aff id="A134">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V. Shane" last="Pankratz">V. Shane Pankratz</name><affiliation><nlm:aff id="A134">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A135">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A136">Unit of Medical Genetics, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation><nlm:aff id="A136">Unit of Medical Genetics, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Zaffaroni, Daniela" sort="Zaffaroni, Daniela" uniqKey="Zaffaroni D" first="Daniela" last="Zaffaroni">Daniela Zaffaroni</name><affiliation><nlm:aff id="A136">Unit of Medical Genetics, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation><nlm:aff id="A137">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bernard, Loris" sort="Bernard, Loris" uniqKey="Bernard L" first="Loris" last="Bernard">Loris Bernard</name><affiliation><nlm:aff id="A138">Department of Experimental Oncology, Istituto Europeo di Oncologia, and Consortium for Genomics Technology (Cogentech), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Viel, Alessandra" sort="Viel, Alessandra" uniqKey="Viel A" first="Alessandra" last="Viel">Alessandra Viel</name><affiliation><nlm:aff id="A139">Unit of Experimental Oncology 1, Centro di Riferimento Oncologico, IRCCS, Aviano (PN), Italy</nlm:aff></affiliation></author><author><name sortKey="Giannini, Giuseppe" sort="Giannini, Giuseppe" uniqKey="Giannini G" first="Giuseppe" last="Giannini">Giuseppe Giannini</name><affiliation><nlm:aff id="A140">Department of Experimental Medicine, University La Sapienza, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Varesco, Liliana" sort="Varesco, Liliana" uniqKey="Varesco L" first="Liliana" last="Varesco">Liliana Varesco</name><affiliation><nlm:aff id="A141">Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, Istituto Nazionale per la Ricerca sul Cancro (IST), Genoa, Italy</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A135">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation><nlm:aff id="A142">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, NCI, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name><affiliation><nlm:aff id="A142">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, NCI, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A6">Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="A7">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A5">Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City (Quebec), Canada</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P3">Genome-wide association studies (GWAS) identified variants at 19p13.1 and <italic>ZNF365</italic> (10q21.2) as risk factors for breast cancer among <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of <italic>BRCA1/2</italic> (CIMBA).</p></sec><sec id="S2"><title>Methods</title><p id="P4">Genotyping data for 12,599 <italic>BRCA1</italic> and 7,132 <italic>BRCA2</italic> mutation carriers from 40 studies were combined.</p></sec><sec id="S3"><title>Results</title><p id="P5">We confirmed associations between rs8170 at 19p13.1 and breast cancer risk for <italic>BRCA1</italic> mutation carriers (hazard ratio (HR)=1.17; 95%CI 1.07–1.27; p=7.42×10<sup>−4</sup>) and between rs16917302 at <italic>ZNF365</italic> (HR=0.84; 95%CI 0.73–0.97; p=0.017) but not rs311499 at 20q13.3 (HR=1.11; 95%CI 0.94–1.31; p=0.22) and breast cancer risk for <italic>BRCA2</italic> mutation carriers. Analyses based on tumor histopathology showed that 19p13 variants were predominantly associated with estrogen receptor (ER)-negative breast cancer for both <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers, whereas rs16917302 at <italic>ZNF365</italic> was mainly associated with ER-positive breast cancer for both <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers. We also found for the first time that rs67397200 at 19p13.1 was associated with an increased risk of ovarian cancer for <italic>BRCA1</italic> (HR=1.16; 95%CI 1.05–1.29; p=3.8×10<sup>−4</sup>) and <italic>BRCA2</italic> mutation carriers (HR=1.30; 95%CI 1.10–1.52; p=1.8×10<sup>−3</sup>).</p></sec><sec id="S4"><title>Conclusions</title><p id="P6">19p13.1 and <italic>ZNF365</italic> are susceptibility loci for ovarian cancer and ER subtypes of breast cancer among <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers.</p></sec><sec id="S5"><title>Impact</title><p id="P7">These findings can lead to an improved understanding of tumor development and may prove useful for breast and ovarian cancer risk prediction for <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9200608</journal-id><journal-id journal-id-type="pubmed-jr-id">2299</journal-id><journal-id journal-id-type="nlm-ta">Cancer Epidemiol Biomarkers Prev</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Epidemiol. Biomarkers Prev.</journal-id><journal-title-group><journal-title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</journal-title></journal-title-group><issn pub-type="ppub">1055-9965</issn><issn pub-type="epub">1538-7755</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22351618</article-id><article-id pub-id-type="pmc">3319317</article-id><article-id pub-id-type="doi">10.1158/1055-9965.EPI-11-0888</article-id><article-id pub-id-type="manuscript">NIHMS347818</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Common variants at the 19p13.1 and <italic>ZNF365</italic> loci are associated with ER subtypes of breast cancer and ovarian cancer risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation 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contrib-type="author"><name><surname>Engel</surname><given-names>Christoph</given-names></name><xref ref-type="aff" rid="A113">113</xref></contrib><contrib contrib-type="author"><name><surname>Meindl</surname><given-names>Alfons</given-names></name><xref ref-type="aff" rid="A114">114</xref></contrib><contrib contrib-type="author"><name><surname>Ditsch</surname><given-names>Nina</given-names></name><xref ref-type="aff" rid="A115">115</xref></contrib><contrib contrib-type="author"><name><surname>Arnold</surname><given-names>Norbert</given-names></name><xref ref-type="aff" rid="A116">116</xref></contrib><contrib contrib-type="author"><name><surname>Heidemann</surname><given-names>Simone</given-names></name><xref ref-type="aff" rid="A117">117</xref></contrib><contrib contrib-type="author"><name><surname>Niederacher</surname><given-names>Dieter</given-names></name><xref ref-type="aff" rid="A118">118</xref></contrib><contrib contrib-type="author"><name><surname>Preisler-Adams</surname><given-names>Sabine</given-names></name><xref ref-type="aff" rid="A119">119</xref></contrib><contrib contrib-type="author"><name><surname>Gadzicki</surname><given-names>Dorothea</given-names></name><xref ref-type="aff" rid="A120">120</xref></contrib><contrib contrib-type="author"><name><surname>Varon-Mateeva</surname><given-names>Raymonda</given-names></name><xref ref-type="aff" rid="A121">121</xref></contrib><contrib contrib-type="author"><name><surname>Deissler</surname><given-names>Helmut</given-names></name><xref ref-type="aff" rid="A122">122</xref></contrib><contrib contrib-type="author"><name><surname>Gehrig</surname><given-names>Andrea</given-names></name><xref ref-type="aff" rid="A123">123</xref></contrib><contrib contrib-type="author"><name><surname>Sutter</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="A124">124</xref></contrib><contrib contrib-type="author"><name><surname>Kast</surname><given-names>Karin</given-names></name><xref ref-type="aff" rid="A125">125</xref></contrib><contrib contrib-type="author"><name><surname>Fiebig</surname><given-names>Britta</given-names></name><xref ref-type="aff" rid="A126">126</xref></contrib><contrib contrib-type="author"><name><surname>Heinritz</surname><given-names>Wolfram</given-names></name><xref ref-type="aff" rid="A127">127</xref></contrib><contrib contrib-type="author"><name><surname>Caldes</surname><given-names>Trinidad</given-names></name><xref ref-type="aff" rid="A128">128</xref></contrib><contrib contrib-type="author"><name><surname>de la Hoya</surname><given-names>Miguel</given-names></name><xref ref-type="aff" rid="A128">128</xref></contrib><contrib contrib-type="author"><name><surname>Muranen</surname><given-names>Taru A.</given-names></name><xref ref-type="aff" rid="A129">129</xref></contrib><contrib contrib-type="author"><name><surname>Nevanlinna</surname><given-names>Heli</given-names></name><xref ref-type="aff" rid="A129">129</xref></contrib><contrib contrib-type="author"><name><surname>Tischkowitz</surname><given-names>Marc D.</given-names></name><xref ref-type="aff" rid="A130">130</xref><xref ref-type="aff" rid="A131">131</xref></contrib><contrib contrib-type="author"><name><surname>Spurdle</surname><given-names>Amanda B.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Neuhausen</surname><given-names>Susan L.</given-names></name><xref ref-type="aff" rid="A132">132</xref></contrib><contrib contrib-type="author"><name><surname>Ding</surname><given-names>Yuan Chun</given-names></name><xref ref-type="aff" rid="A132">132</xref></contrib><contrib contrib-type="author"><name><surname>Lindor</surname><given-names>Noralane M.</given-names></name><xref ref-type="aff" rid="A133">133</xref></contrib><contrib contrib-type="author"><name><surname>Fredericksen</surname><given-names>Zachary</given-names></name><xref ref-type="aff" rid="A134">134</xref></contrib><contrib contrib-type="author"><name><surname>Pankratz</surname><given-names>V. Shane</given-names></name><xref ref-type="aff" rid="A134">134</xref></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A135">135</xref></contrib><contrib contrib-type="author"><name><surname>Manoukian</surname><given-names>Siranoush</given-names></name><xref ref-type="aff" rid="A136">136</xref></contrib><contrib contrib-type="author"><name><surname>Peissel</surname><given-names>Bernard</given-names></name><xref ref-type="aff" rid="A136">136</xref></contrib><contrib contrib-type="author"><name><surname>Zaffaroni</surname><given-names>Daniela</given-names></name><xref ref-type="aff" rid="A136">136</xref></contrib><contrib contrib-type="author"><name><surname>Barile</surname><given-names>Monica</given-names></name><xref ref-type="aff" rid="A137">137</xref></contrib><contrib contrib-type="author"><name><surname>Bernard</surname><given-names>Loris</given-names></name><xref ref-type="aff" rid="A138">138</xref></contrib><contrib contrib-type="author"><name><surname>Viel</surname><given-names>Alessandra</given-names></name><xref ref-type="aff" rid="A139">139</xref></contrib><contrib contrib-type="author"><name><surname>Giannini</surname><given-names>Giuseppe</given-names></name><xref ref-type="aff" rid="A140">140</xref></contrib><contrib contrib-type="author"><name><surname>Varesco</surname><given-names>Liliana</given-names></name><xref ref-type="aff" rid="A141">141</xref></contrib><contrib contrib-type="author"><name><surname>Radice</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A135">135</xref></contrib><contrib contrib-type="author"><name><surname>Greene</surname><given-names>Mark H.</given-names></name><xref ref-type="aff" rid="A142">142</xref></contrib><contrib contrib-type="author"><name><surname>Mai</surname><given-names>Phuong L.</given-names></name><xref ref-type="aff" rid="A142">142</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><collab>for kConFab investigators</collab></contrib><contrib contrib-type="author"><name><surname>Offit</surname><given-names>Kenneth</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="author-notes" rid="FN2">*</xref></contrib><contrib contrib-type="author"><name><surname>Simard</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="author-notes" rid="FN2">*</xref></contrib><on-behalf-of>on behalf of the Consortium of Investigators of Modifiers of <italic>BRCA1/2</italic></on-behalf-of></contrib-group><aff id="A1"><label>1</label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</aff><aff id="A2"><label>2</label>Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA</aff><aff id="A3"><label>3</label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</aff><aff id="A4"><label>4</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, USA</aff><aff id="A5"><label>5</label>Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City (Quebec), Canada</aff><aff id="A6"><label>6</label>Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</aff><aff id="A7"><label>7</label>Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, USA</aff><aff id="A8"><label>8</label>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon / Centre Léon Bérard, Lyon, France</aff><aff id="A9"><label>9</label>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</aff><aff id="A10"><label>10</label>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Cancer Care Ontario, Department of Molecular Genetics, University of Toronto, Ontario, Canada</aff><aff id="A11"><label>11</label>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Cancer Care Ontario, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada</aff><aff id="A12"><label>12</label>Ontario Cancer Genetics Network: Cancer Care Ontario, Canada</aff><aff id="A13"><label>13</label>Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada</aff><aff id="A14"><label>14</label>Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</aff><aff id="A15"><label>15</label>Department of Clincial Genetics, Rigshospitalet, København, Denmark</aff><aff id="A16"><label>16</label>Department of Clinical Genetics, Skejby Hospital, Århus, Denmark</aff><aff id="A17"><label>17</label>Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</aff><aff id="A18"><label>18</label>Section of Genetic Oncology, University Hospital of Pisa, Pisa, Italy</aff><aff id="A19"><label>19</label>Department of Oncology, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A20"><label>20</label>Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A21"><label>21</label>Department of Oncology, Lund University Hospital, Lund, Sweden</aff><aff id="A22"><label>22</label>Department of Clinical Genetics. Lund University Hospital, Lund, Sweden</aff><aff id="A23"><label>23</label>Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</aff><aff id="A24"><label>24</label>Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden</aff><aff id="A25"><label>25</label>Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</aff><aff id="A26"><label>26</label>Department of Biostatistics and Epidemiology, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</aff><aff id="A27"><label>27</label>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff><aff id="A28"><label>28</label>Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland</aff><aff id="A29"><label>29</label>Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, and Spanish Network on Rare Diseases (CIBERER), Madrid, Spain</aff><aff id="A30"><label>30</label>Institute of Biology and Molecular Genetics. Universidad de Valladolid (IBGM-UVA), Valladolid, Spain</aff><aff id="A31"><label>31</label>Molecular Genetics Laboratory (Department of Biochemistry), Cruces Hospital Barakaldo, Bizkaia, Spain</aff><aff id="A32"><label>32</label>Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, and Spanish Network on Rare Diseases (CIBERER), Madrid, Spain</aff><aff id="A33"><label>33</label>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</aff><aff id="A34"><label>34</label>Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands</aff><aff id="A35"><label>35</label>Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands</aff><aff id="A36"><label>36</label>Department of Epidemiology. Head, Division of Psychosocial Research & Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</aff><aff id="A37"><label>37</label>Department of Clinical Genetics, VU Medical Center, Amsterdam, The Netherlands</aff><aff id="A38"><label>38</label>Department of Human Genetics & Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A39"><label>39</label>Department of Genetics and Cell Biology, University Medical Center, Maastricht, The Netherlands</aff><aff id="A40"><label>40</label>Hereditary Cancer Clinic, Radboud University Nijmegen Medical Center, The Netherlands</aff><aff id="A41"><label>41</label>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A42"><label>42</label>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A43"><label>43</label>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</aff><aff id="A44"><label>44</label>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK</aff><aff id="A45"><label>45</label>Clinical Genetics, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK</aff><aff id="A46"><label>46</label>Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK</aff><aff id="A47"><label>47</label>Yorkshire Regional Genetics Service, Leeds, UK</aff><aff id="A48"><label>48</label>Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals, Glasgow, UK</aff><aff id="A49"><label>49</label>University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton UK</aff><aff id="A50"><label>50</label>West Midlands Regional Genetics Service, Birmingham Women’s Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK</aff><aff id="A51"><label>51</label>Sheffield Clinical Genetics Service, Sheffield Children’s Hospital, Sheffield, UK</aff><aff id="A52"><label>52</label>Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital, Cambridge, UK</aff><aff id="A53"><label>53</label>Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, UK</aff><aff id="A54"><label>54</label>Institute of Genetic Medicine, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK</aff><aff id="A55"><label>55</label>Medical Genetics Unit, St George's, University of London, UK</aff><aff id="A56"><label>56</label>Northern Ireland Regional Genetics Centre, Belfast Health and Social Care Trust, and Department of Medical Genetics, Queens University Belfast, Belfast UK</aff><aff id="A57"><label>57</label>Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK</aff><aff id="A58"><label>58</label>South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK</aff><aff id="A59"><label>59</label>Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Ireland</aff><aff id="A60"><label>60</label>North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK</aff><aff id="A61"><label>61</label>Clinical Molecular Genetics Laboratory, Fox Chase Cancer Center, Philadelphia, PA, USA</aff><aff id="A62"><label>62</label>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA</aff><aff id="A63"><label>63</label>GEMO Study Collaborators: Cancer Genetics Network “Groupe Génétique et Cancer”, Fédération Nationale des Centres de Lutte Contre le Cancer, France</aff><aff id="A64"><label>64</label>Service de Génétique Oncologique, Institut Curie, Paris, France</aff><aff id="A65"><label>65</label>Unité INSERM U830, Institut Curie, Paris, France</aff><aff id="A66"><label>66</label>Université Paris Descartes, Faculté de Médecine, Paris, France</aff><aff id="A67"><label>67</label>Genetic Unit, Avicenne Hospital, Assitance Publique-Hôpitaux de Paris, Paris, France</aff><aff id="A68"><label>68</label>Sud-Francilien Hospital, Evry-Corbeil, France</aff><aff id="A69"><label>69</label>University Hospital, Clermont-Ferrand, France</aff><aff id="A70"><label>70</label>Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif, France</aff><aff id="A71"><label>71</label>Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</aff><aff id="A72"><label>72</label>Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France</aff><aff id="A73"><label>73</label>Service Oncologie Médicale, Centre René Gauducheau, Nantes, France</aff><aff id="A74"><label>74</label>Department of Preventive Medicine, Creighton University, Omaha, NE, USA</aff><aff id="A75"><label>75</label>Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA</aff><aff id="A76"><label>76</label>Fox Chase Cancer Center, Philadelphia, PA, USA</aff><aff id="A77"><label>77</label>Department of Epidemiology, Columbia University, New York, NY, USA</aff><aff id="A78"><label>78</label>Department of Epidemiology, Cancer Prevention Institute of California, Fremont, CA, USA</aff><aff id="A79"><label>79</label>Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA</aff><aff id="A80"><label>80</label>Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia</aff><aff id="A81"><label>81</label>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Victoria, Australia</aff><aff id="A82"><label>82</label>Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA</aff><aff id="A83"><label>83</label>Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</aff><aff id="A84"><label>84</label>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark</aff><aff id="A85"><label>85</label>Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland</aff><aff id="A86"><label>86</label>Faculty of Medicine, University of Iceland, Reykjavik, Iceland</aff><aff id="A87"><label>87</label>Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, 666 Elm St, Buffalo, NY, USA</aff><aff id="A88"><label>88</label>Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia and Department of Medicine, St Vincent’s Hospital, The University of Melbourne, Victoria, Australia</aff><aff id="A89"><label>89</label>Good Samaritan Hospital, Department of Obstetrics and Gynecology, GOG affilitate</aff><aff id="A90"><label>90</label>Center for Medical Genetics, NorthShore University Health System, Evanston, IL, USA</aff><aff id="A91"><label>91</label>Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, IL, USA</aff><aff id="A92"><label>92</label>University of North Carolina, Chapel Hill, NC, USA</aff><aff id="A93"><label>93</label>Dana-Farber/Brigham and Women's Cancer Center in clinical affiliation with South Shore Hospital, South Weymouth, MA, USA</aff><aff id="A94"><label>94</label>Departments of Molecular Virology, Immunology & Medical Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA</aff><aff id="A95"><label>95</label>Istituto Oncologico Veneto IOV - IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy</aff><aff id="A96"><label>96</label>Laboratory of Molecular Oncology, N.N. Petrov Institute of Oncology, St.-Petersburg, Russia</aff><aff id="A97"><label>97</label>Fisher Center for Familial Cancer Research, Lombardi Comprehensive Cancer Center, Georgetown University, Washington D.C., USA</aff><aff id="A98"><label>98</label>Dept. of Molecular and Regenerative medicine, Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Santariskiu st. 2, Vilnius, Lithuania</aff><aff id="A99"><label>99</label>Molecular Diagnostic Unit, Hereditari Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</aff><aff id="A100"><label>100</label>Genetic Counseling Unit, Hereditari Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</aff><aff id="A101"><label>101</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, USA</aff><aff id="A102"><label>102</label>Department of Oncology, University of Cambridge, Cambridge, UK</aff><aff id="A103"><label>103</label>Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA</aff><aff id="A104"><label>104</label>Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</aff><aff id="A105"><label>105</label>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</aff><aff id="A106"><label>106</label>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya, Malaysia and Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</aff><aff id="A107"><label>107</label>UCLA School of Public Health, Department of Health Services, Los Angeles, CA, USA</aff><aff id="A108"><label>108</label>Department of Medicine, Epidemiology and Biostatistics, University of California, San Francisco, CA, USA</aff><aff id="A109"><label>109</label>Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, South Africa</aff><aff id="A110"><label>110</label>Molecular Medicine and Genetics Program. Vall d'Hebron University Hospital. Oncogenetics Laboratory. Vall d'Hebron Institute of Oncology (VHIO). Barcelona, Spain</aff><aff id="A111"><label>111</label>Hong Kong Hereditary Breast Cancer Family Registry and Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong</aff><aff id="A112"><label>112</label>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany</aff><aff id="A113"><label>113</label>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany</aff><aff id="A114"><label>114</label>Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany</aff><aff id="A115"><label>115</label>Department of Gynaecology and Obstetrics, Ludwig-Maximilian University Munich, Germany</aff><aff id="A116"><label>116</label>Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany</aff><aff id="A117"><label>117</label>Institute of Human Genetics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany</aff><aff id="A118"><label>118</label>Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University, Düsseldorf, Germany</aff><aff id="A119"><label>119</label>Institute of Human Genetics, University of Münster, Münster, Germany</aff><aff id="A120"><label>120</label>Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany</aff><aff id="A121"><label>121</label>Institute of Human Genetics, Campus Virchov Klinikum, Berlin, Germany</aff><aff id="A122"><label>122</label>Department of Gynaecology and Obstetrics, University Hospital Ulm, Germany</aff><aff id="A123"><label>123</label>Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Germany</aff><aff id="A124"><label>124</label>Institute of Human Genetics, Division of Molecular Genetics, University Heidelberg, Germany</aff><aff id="A125"><label>125</label>Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Germany</aff><aff id="A126"><label>126</label>Institute of Human Genetics, University Regensburg, Germany</aff><aff id="A127"><label>127</label>Institute of Human Genetics, University Leipzig, Germany</aff><aff id="A128"><label>128</label>Molecular Oncology Laboratory, Hospital Clinico San Carlos. Martin Lagos s/n, 28040 Madrid, Spain</aff><aff id="A129"><label>129</label>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki, Helsinki, Finland</aff><aff id="A130"><label>130</label>Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada</aff><aff id="A131"><label>131</label>Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, Quebec, Canada</aff><aff id="A132"><label>132</label>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA USA</aff><aff id="A133"><label>133</label>Department of Medical Genetics, Mayo Clinic Rochester, MN, USA</aff><aff id="A134"><label>134</label>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</aff><aff id="A135"><label>135</label>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</aff><aff id="A136"><label>136</label>Unit of Medical Genetics, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</aff><aff id="A137"><label>137</label>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</aff><aff id="A138"><label>138</label>Department of Experimental Oncology, Istituto Europeo di Oncologia, and Consortium for Genomics Technology (Cogentech), Milan, Italy</aff><aff id="A139"><label>139</label>Unit of Experimental Oncology 1, Centro di Riferimento Oncologico, IRCCS, Aviano (PN), Italy</aff><aff id="A140"><label>140</label>Department of Experimental Medicine, University La Sapienza, Rome, Italy</aff><aff id="A141"><label>141</label>Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, Istituto Nazionale per la Ricerca sul Cancro (IST), Genoa, Italy</aff><aff id="A142"><label>142</label>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, NCI, Rockville, MD, USA</aff><author-notes><corresp id="cor1"><bold>Corresponding Author:</bold> Fergus Couch, Mayo Clinic, Stabile 2-42, 200 First Street SW, Rochester, MN 55905, USA; Tel: 507-284-3623; Fax: 507-538-1937; <email>couch.fergus@mayo.edu</email></corresp><fn id="FN1" fn-type="equal"><label>#</label><p id="P1">F.J. Couch and M.M. Gaudet contributed equally as primary authors.</p></fn><fn id="FN2" fn-type="equal"><label>*</label><p id="P2">K. Offit and J. Simard contributed equally as senior authors</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>31</day><month>1</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>20</day><month>2</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2012</year></pub-date><volume>21</volume><issue>4</issue><fpage>645</fpage><lpage>657</lpage><abstract><sec id="S1"><title>Background</title><p id="P3">Genome-wide association studies (GWAS) identified variants at 19p13.1 and <italic>ZNF365</italic> (10q21.2) as risk factors for breast cancer among <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of <italic>BRCA1/2</italic> (CIMBA).</p></sec><sec id="S2"><title>Methods</title><p id="P4">Genotyping data for 12,599 <italic>BRCA1</italic> and 7,132 <italic>BRCA2</italic> mutation carriers from 40 studies were combined.</p></sec><sec id="S3"><title>Results</title><p id="P5">We confirmed associations between rs8170 at 19p13.1 and breast cancer risk for <italic>BRCA1</italic> mutation carriers (hazard ratio (HR)=1.17; 95%CI 1.07–1.27; p=7.42×10<sup>−4</sup>) and between rs16917302 at <italic>ZNF365</italic> (HR=0.84; 95%CI 0.73–0.97; p=0.017) but not rs311499 at 20q13.3 (HR=1.11; 95%CI 0.94–1.31; p=0.22) and breast cancer risk for <italic>BRCA2</italic> mutation carriers. Analyses based on tumor histopathology showed that 19p13 variants were predominantly associated with estrogen receptor (ER)-negative breast cancer for both <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers, whereas rs16917302 at <italic>ZNF365</italic> was mainly associated with ER-positive breast cancer for both <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers. We also found for the first time that rs67397200 at 19p13.1 was associated with an increased risk of ovarian cancer for <italic>BRCA1</italic> (HR=1.16; 95%CI 1.05–1.29; p=3.8×10<sup>−4</sup>) and <italic>BRCA2</italic> mutation carriers (HR=1.30; 95%CI 1.10–1.52; p=1.8×10<sup>−3</sup>).</p></sec><sec id="S4"><title>Conclusions</title><p id="P6">19p13.1 and <italic>ZNF365</italic> are susceptibility loci for ovarian cancer and ER subtypes of breast cancer among <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers.</p></sec><sec id="S5"><title>Impact</title><p id="P7">These findings can lead to an improved understanding of tumor development and may prove useful for breast and ovarian cancer risk prediction for <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers.</p></sec></abstract><kwd-group><kwd>BRCA1</kwd><kwd>BRCA2</kwd><kwd>breast cancer risk</kwd><kwd>ovarian cancer risk</kwd><kwd>19p13.1</kwd><kwd>ZNF365</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA128978-04 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>P50 CA116201-07 || CA</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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