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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer</title><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A1">Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name><affiliation><nlm:aff id="A5">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="A7">Sections of Epidemiology and Genetics, Institute of Cancer Research and Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A6">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A8">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation><nlm:aff id="A9">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Fredericksen, Zachary" sort="Fredericksen, Zachary" uniqKey="Fredericksen Z" first="Zachary" last="Fredericksen">Zachary Fredericksen</name><affiliation><nlm:aff id="A5">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Núria" last="Malats">Núria Malats</name><affiliation><nlm:aff id="A1">Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="A13">Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Perez, Jose Ignacio Arias" sort="Perez, Jose Ignacio Arias" uniqKey="Perez J" first="Jose Ignacio Arias" last="Pérez">Jose Ignacio Arias Pérez</name><affiliation><nlm:aff id="A14">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><nlm:aff id="A2">Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="A15">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Schurmann, Peter" sort="Schurmann, Peter" uniqKey="Schurmann P" first="Peter" last="Schürmann">Peter Schürmann</name><affiliation><nlm:aff id="A15">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Karstens, Johann H" sort="Karstens, Johann H" uniqKey="Karstens J" first="Johann H." last="Karstens">Johann H. Karstens</name><affiliation><nlm:aff id="A16">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name><affiliation><nlm:aff id="A15">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A17">Institute for Cancer Studies, Department of Oncology, University of Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Brock, Ian W" sort="Brock, Ian W" uniqKey="Brock I" first="Ian W." last="Brock">Ian W. Brock</name><affiliation><nlm:aff id="A17">Institute for Cancer Studies, Department of Oncology, University of Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Elliot, Graeme" sort="Elliot, Graeme" uniqKey="Elliot G" first="Graeme" last="Elliot">Graeme Elliot</name><affiliation><nlm:aff id="A17">Institute for Cancer Studies, Department of Oncology, University of Sheffield, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A19">University of Manchester, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="A18">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Seal, Sheila" sort="Seal, Sheila" uniqKey="Seal S" first="Sheila" last="Seal">Sheila Seal</name><affiliation><nlm:aff id="A20">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK</nlm:aff></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation><nlm:aff id="A20">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK</nlm:aff></affiliation></author><author><name sortKey="Renwick, Anthony" sort="Renwick, Anthony" uniqKey="Renwick A" first="Anthony" last="Renwick">Anthony Renwick</name><affiliation><nlm:aff id="A20">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK</nlm:aff></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation><nlm:aff id="A20">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK</nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="A21">Institute of Biomedical Sciences, Academia Sinica, and Taiwan Biobank, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name><affiliation><nlm:aff id="A22">Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Huang, Chiun Sheng" sort="Huang, Chiun Sheng" uniqKey="Huang C" first="Chiun-Sheng" last="Huang">Chiun-Sheng Huang</name><affiliation><nlm:aff id="A23">Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hou, Ming Feng" sort="Hou, Ming Feng" uniqKey="Hou M" first="Ming-Feng" last="Hou">Ming-Feng Hou</name><affiliation><nlm:aff id="A24">Cancer Center and Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="A25">Copenhagen General Population Study and Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A25">Copenhagen General Population Study and Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Lanng, Charlotte" sort="Lanng, Charlotte" uniqKey="Lanng C" first="Charlotte" last="Lanng">Charlotte Lanng</name><affiliation><nlm:aff id="A26">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Aln S, Grethe Grenaker" sort="Aln S, Grethe Grenaker" uniqKey="Aln S G" first="Grethe Grenaker" last="Aln S">Grethe Grenaker Aln S</name><affiliation><nlm:aff id="A27">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="A27">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Faculty of Medicine (Faculty Division Ahus), UiO, Norway</nlm:aff></affiliation></author><author><name sortKey="B Rrensen Dale, Anne Lise" sort="B Rrensen Dale, Anne Lise" uniqKey="B Rrensen Dale A" first="Anne-Lise" last="B Rrensen-Dale">Anne-Lise B Rrensen-Dale</name><affiliation><nlm:aff id="A27">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Faculty of Medicine (Faculty Division Ahus), UiO, Norway</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A3">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Dite, Gillian S" sort="Dite, Gillian S" uniqKey="Dite G" first="Gillian S." last="Dite">Gillian S. Dite</name><affiliation><nlm:aff id="A3">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="A3">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A4">Department of Pathology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A29">Vesalius Research Center (VRC), VIB, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Yesilyurt, Betul T" sort="Yesilyurt, Betul T" uniqKey="Yesilyurt B" first="Betül T." last="Yesilyurt">Betül T. Yesilyurt</name><affiliation><nlm:aff id="A29">Vesalius Research Center (VRC), VIB, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation><nlm:aff id="A30">Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Leunen, Karin" sort="Leunen, Karin" uniqKey="Leunen K" first="Karin" last="Leunen">Karin Leunen</name><affiliation><nlm:aff id="A30">Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="A31">National Cancer Institute, Bangkok, Thailand</nlm:aff></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation><nlm:aff id="A32">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="A32">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation><nlm:aff id="A32">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A9">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation><nlm:aff id="A33">Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A34">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A36">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A34">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A36">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A35">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation><nlm:aff id="A37">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A8">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="A8">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="A38">Cancer Prevention Institute of California, Fremont and Stanford University School of Medicine, Stanford, California, USA</nlm:aff></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation><nlm:aff id="A39">Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A40">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="A41">Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Sherman, Mark E" sort="Sherman, Mark E" uniqKey="Sherman M" first="Mark E." last="Sherman">Mark E. Sherman</name><affiliation><nlm:aff id="A40">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:aff id="A40">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="A15">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Antonenkova, Natalia N" sort="Antonenkova, Natalia N" uniqKey="Antonenkova N" first="Natalia N." last="Antonenkova">Natalia N. Antonenkova</name><affiliation><nlm:aff id="A42">N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</nlm:aff></affiliation></author><author><name sortKey="Zalutsky, Iosif V" sort="Zalutsky, Iosif V" uniqKey="Zalutsky I" first="Iosif V." last="Zalutsky">Iosif V. Zalutsky</name><affiliation><nlm:aff id="A42">N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</nlm:aff></affiliation></author><author><name sortKey="Rogov, Yuri I" sort="Rogov, Yuri I" uniqKey="Rogov Y" first="Yuri I." last="Rogov">Yuri I. Rogov</name><affiliation><nlm:aff id="A42">N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A43">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A44">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Bayer, Christian M" sort="Bayer, Christian M" uniqKey="Bayer C" first="Christian M." last="Bayer">Christian M. Bayer</name><affiliation><nlm:aff id="A43">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="A45">Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A43">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A10">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name><affiliation><nlm:aff id="A10">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A10">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="A46">Saarland Cancer Registry, Saarbrücken, Germany</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A47">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Fred A. Litwin Center for Cancer Genetics, Mount Sinai Hospital, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="A49">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A47">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="A52">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Department of Laboratory Medicine and Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A54">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Biocenter Kuopio, Kuopio Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="A54">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Biocenter Kuopio, Kuopio Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Department of Oncology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A54">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Biocenter Kuopio, Kuopio Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="A54">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Biocenter Kuopio, Kuopio Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A58">Division of Gynecology and Obstetrics, Klinikum rechts der Isar at the Technical University Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Heil, Joerg" sort="Heil, Joerg" uniqKey="Heil J" first="Joerg" last="Heil">Joerg Heil</name><affiliation><nlm:aff id="A59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Bartram, Claus R" sort="Bartram, Claus R" uniqKey="Bartram C" first="Claus R." last="Bartram">Claus R. Bartram</name><affiliation><nlm:aff id="A60">Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A62">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Center of Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Thomas, Gilles D" sort="Thomas, Gilles D" uniqKey="Thomas G" first="Gilles D." last="Thomas">Gilles D. Thomas</name><affiliation><nlm:aff id="A40">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N." last="Hoover">Robert N. Hoover</name><affiliation><nlm:aff id="A40">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A63">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gibson, Lorna J" sort="Gibson, Lorna J" uniqKey="Gibson L" first="Lorna J." last="Gibson">Lorna J. Gibson</name><affiliation><nlm:aff id="A64">London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Silva, Isabel Dos Santos" sort="Silva, Isabel Dos Santos" uniqKey="Silva I" first="Isabel Dos Santos" last="Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="A64">London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="A64">London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Nickels, Stefan" sort="Nickels, Stefan" uniqKey="Nickels S" first="Stefan" last="Nickels">Stefan Nickels</name><affiliation><nlm:aff id="A9">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A65">Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A66">Department of Epidemiology, University of California Irvine, Irvine, California, USA</nlm:aff></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation><nlm:aff id="A66">Department of Epidemiology, University of California Irvine, Irvine, California, USA</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><affiliation><nlm:aff id="A67">Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="A68">Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name><affiliation><nlm:aff id="A69">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="A69">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A70">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="A70">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Veer, Laura J" sort="Van Veer, Laura J" uniqKey="Van Veer L" first="Laura J." last="Van Veer">Laura J. Van Veer</name><affiliation><nlm:aff id="A70">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Rob A E M" sort="Tollenaar, Rob A E M" uniqKey="Tollenaar R" first="Rob A. E. M." last="Tollenaar">Rob A. E. M. Tollenaar</name><affiliation><nlm:aff id="A71">Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="A72">Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A72">Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name><affiliation><nlm:aff id="A73">Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="A59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A61">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation><nlm:aff id="A59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A61">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><affiliation><nlm:aff id="A59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="A11">Molecular Epidemiology Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A75">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A75">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="A75">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="A75">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="A77">Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Yoo, Keun Young" sort="Yoo, Keun Young" uniqKey="Yoo K" first="Keun-Young" last="Yoo">Keun-Young Yoo</name><affiliation><nlm:aff id="A77">Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Noh, Dong Young" sort="Noh, Dong Young" uniqKey="Noh D" first="Dong-Young" last="Noh">Dong-Young Noh</name><affiliation><nlm:aff id="A77">Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Ahn, Sei Hyun" sort="Ahn, Sei Hyun" uniqKey="Ahn S" first="Sei-Hyun" last="Ahn">Sei-Hyun Ahn</name><affiliation><nlm:aff id="A78">Ulsan University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A79">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name><affiliation><nlm:aff id="A80">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A79">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation><nlm:aff id="A79">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation><nlm:aff id="A82">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A82">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A12">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Harth, Volker" sort="Harth, Volker" uniqKey="Harth V" first="Volker" last="Harth">Volker Harth</name><affiliation><nlm:aff id="A83">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name><affiliation><nlm:aff id="A84">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A85">University of Tübingen, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A86">Laboratory of Cancer Genetics, Department of Clinical Genetics, Oulu University Hospital, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Biocenter Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="A86">Laboratory of Cancer Genetics, Department of Clinical Genetics, Oulu University Hospital, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Biocenter Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="A88">Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name><affiliation><nlm:aff id="A89">Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje" sort="Hooning, Maartje" uniqKey="Hooning M" first="Maartje" last="Hooning">Maartje Hooning</name><affiliation><nlm:aff id="A90">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="A91">Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Oldenburg, Rogier A" sort="Oldenburg, Rogier A" uniqKey="Oldenburg R" first="Rogier A." last="Oldenburg">Rogier A. Oldenburg</name><affiliation><nlm:aff id="A92">Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tilanus Linthorst, Madeleine" sort="Tilanus Linthorst, Madeleine" uniqKey="Tilanus Linthorst M" first="Madeleine" last="Tilanus-Linthorst">Madeleine Tilanus-Linthorst</name><affiliation><nlm:aff id="A93">Department of Surgical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name><affiliation><nlm:aff id="A94">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Bermisheva, Marina" sort="Bermisheva, Marina" uniqKey="Bermisheva M" first="Marina" last="Bermisheva">Marina Bermisheva</name><affiliation><nlm:aff id="A94">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Prokofieva, Darya" sort="Prokofieva, Darya" uniqKey="Prokofieva D" first="Darya" last="Prokofieva">Darya Prokofieva</name><affiliation><nlm:aff id="A94">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Farahtdinova, Albina" sort="Farahtdinova, Albina" uniqKey="Farahtdinova A" first="Albina" last="Farahtdinova">Albina Farahtdinova</name><affiliation><nlm:aff id="A94">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="A5">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="A6">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Manjeet K" sort="Humphreys, Manjeet K" uniqKey="Humphreys M" first="Manjeet K." last="Humphreys">Manjeet K. Humphreys</name><affiliation><nlm:aff id="A74">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="A74">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A82">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A73">Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21795498</idno><idno type="pmc">4164116</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164116</idno><idno type="RBID">PMC:4164116</idno><idno type="doi">10.1158/1055-9965.EPI-11-0569</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002084</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002084</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer</title><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A1">Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name><affiliation><nlm:aff id="A5">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="A7">Sections of Epidemiology and Genetics, Institute of Cancer Research and Breakthrough Breast Cancer Research Centre, London, UK</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A6">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A8">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation><nlm:aff id="A9">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Fredericksen, Zachary" sort="Fredericksen, Zachary" uniqKey="Fredericksen Z" first="Zachary" last="Fredericksen">Zachary Fredericksen</name><affiliation><nlm:aff id="A5">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Núria" last="Malats">Núria Malats</name><affiliation><nlm:aff id="A1">Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="A13">Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Perez, Jose Ignacio Arias" sort="Perez, Jose Ignacio Arias" uniqKey="Perez J" first="Jose Ignacio Arias" last="Pérez">Jose Ignacio Arias Pérez</name><affiliation><nlm:aff id="A14">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><nlm:aff id="A2">Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="A15">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Schurmann, Peter" sort="Schurmann, Peter" uniqKey="Schurmann P" first="Peter" last="Schürmann">Peter Schürmann</name><affiliation><nlm:aff id="A15">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Karstens, Johann H" sort="Karstens, Johann H" uniqKey="Karstens J" first="Johann H." last="Karstens">Johann H. Karstens</name><affiliation><nlm:aff id="A16">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name><affiliation><nlm:aff id="A15">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A17">Institute for Cancer Studies, Department of Oncology, University of Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Brock, Ian W" sort="Brock, Ian W" uniqKey="Brock I" first="Ian W." last="Brock">Ian W. Brock</name><affiliation><nlm:aff id="A17">Institute for Cancer Studies, Department of Oncology, University of Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Elliot, Graeme" sort="Elliot, Graeme" uniqKey="Elliot G" first="Graeme" last="Elliot">Graeme Elliot</name><affiliation><nlm:aff id="A17">Institute for Cancer Studies, Department of Oncology, University of Sheffield, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A19">University of Manchester, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="A18">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Seal, Sheila" sort="Seal, Sheila" uniqKey="Seal S" first="Sheila" last="Seal">Sheila Seal</name><affiliation><nlm:aff id="A20">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK</nlm:aff></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation><nlm:aff id="A20">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK</nlm:aff></affiliation></author><author><name sortKey="Renwick, Anthony" sort="Renwick, Anthony" uniqKey="Renwick A" first="Anthony" last="Renwick">Anthony Renwick</name><affiliation><nlm:aff id="A20">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK</nlm:aff></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation><nlm:aff id="A20">Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK</nlm:aff></affiliation></author><author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name><affiliation><nlm:aff id="A21">Institute of Biomedical Sciences, Academia Sinica, and Taiwan Biobank, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name><affiliation><nlm:aff id="A22">Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Huang, Chiun Sheng" sort="Huang, Chiun Sheng" uniqKey="Huang C" first="Chiun-Sheng" last="Huang">Chiun-Sheng Huang</name><affiliation><nlm:aff id="A23">Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hou, Ming Feng" sort="Hou, Ming Feng" uniqKey="Hou M" first="Ming-Feng" last="Hou">Ming-Feng Hou</name><affiliation><nlm:aff id="A24">Cancer Center and Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="A25">Copenhagen General Population Study and Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A25">Copenhagen General Population Study and Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Lanng, Charlotte" sort="Lanng, Charlotte" uniqKey="Lanng C" first="Charlotte" last="Lanng">Charlotte Lanng</name><affiliation><nlm:aff id="A26">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Aln S, Grethe Grenaker" sort="Aln S, Grethe Grenaker" uniqKey="Aln S G" first="Grethe Grenaker" last="Aln S">Grethe Grenaker Aln S</name><affiliation><nlm:aff id="A27">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="A27">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Faculty of Medicine (Faculty Division Ahus), UiO, Norway</nlm:aff></affiliation></author><author><name sortKey="B Rrensen Dale, Anne Lise" sort="B Rrensen Dale, Anne Lise" uniqKey="B Rrensen Dale A" first="Anne-Lise" last="B Rrensen-Dale">Anne-Lise B Rrensen-Dale</name><affiliation><nlm:aff id="A27">Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Faculty of Medicine (Faculty Division Ahus), UiO, Norway</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A3">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Dite, Gillian S" sort="Dite, Gillian S" uniqKey="Dite G" first="Gillian S." last="Dite">Gillian S. Dite</name><affiliation><nlm:aff id="A3">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="A3">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A4">Department of Pathology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A29">Vesalius Research Center (VRC), VIB, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Yesilyurt, Betul T" sort="Yesilyurt, Betul T" uniqKey="Yesilyurt B" first="Betül T." last="Yesilyurt">Betül T. Yesilyurt</name><affiliation><nlm:aff id="A29">Vesalius Research Center (VRC), VIB, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation><nlm:aff id="A30">Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Leunen, Karin" sort="Leunen, Karin" uniqKey="Leunen K" first="Karin" last="Leunen">Karin Leunen</name><affiliation><nlm:aff id="A30">Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name><affiliation><nlm:aff id="A31">National Cancer Institute, Bangkok, Thailand</nlm:aff></affiliation></author><author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name><affiliation><nlm:aff id="A32">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="A32">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation><nlm:aff id="A32">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A9">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation><nlm:aff id="A33">Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A34">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A36">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A34">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A36">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A35">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation><nlm:aff id="A37">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A8">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="A8">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="A38">Cancer Prevention Institute of California, Fremont and Stanford University School of Medicine, Stanford, California, USA</nlm:aff></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation><nlm:aff id="A39">Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A40">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="A41">Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Sherman, Mark E" sort="Sherman, Mark E" uniqKey="Sherman M" first="Mark E." last="Sherman">Mark E. Sherman</name><affiliation><nlm:aff id="A40">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:aff id="A40">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="A15">Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Antonenkova, Natalia N" sort="Antonenkova, Natalia N" uniqKey="Antonenkova N" first="Natalia N." last="Antonenkova">Natalia N. Antonenkova</name><affiliation><nlm:aff id="A42">N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</nlm:aff></affiliation></author><author><name sortKey="Zalutsky, Iosif V" sort="Zalutsky, Iosif V" uniqKey="Zalutsky I" first="Iosif V." last="Zalutsky">Iosif V. Zalutsky</name><affiliation><nlm:aff id="A42">N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</nlm:aff></affiliation></author><author><name sortKey="Rogov, Yuri I" sort="Rogov, Yuri I" uniqKey="Rogov Y" first="Yuri I." last="Rogov">Yuri I. Rogov</name><affiliation><nlm:aff id="A42">N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A43">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A44">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Bayer, Christian M" sort="Bayer, Christian M" uniqKey="Bayer C" first="Christian M." last="Bayer">Christian M. Bayer</name><affiliation><nlm:aff id="A43">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="A45">Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A43">University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A10">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name><affiliation><nlm:aff id="A10">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A10">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="A46">Saarland Cancer Registry, Saarbrücken, Germany</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A47">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Fred A. Litwin Center for Cancer Genetics, Mount Sinai Hospital, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="A49">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A47">Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="A52">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Department of Laboratory Medicine and Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A54">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Biocenter Kuopio, Kuopio Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="A54">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Biocenter Kuopio, Kuopio Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Department of Oncology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A54">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Biocenter Kuopio, Kuopio Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="A54">School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Biocenter Kuopio, Kuopio Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A58">Division of Gynecology and Obstetrics, Klinikum rechts der Isar at the Technical University Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Heil, Joerg" sort="Heil, Joerg" uniqKey="Heil J" first="Joerg" last="Heil">Joerg Heil</name><affiliation><nlm:aff id="A59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Bartram, Claus R" sort="Bartram, Claus R" uniqKey="Bartram C" first="Claus R." last="Bartram">Claus R. Bartram</name><affiliation><nlm:aff id="A60">Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A62">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Center of Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Thomas, Gilles D" sort="Thomas, Gilles D" uniqKey="Thomas G" first="Gilles D." last="Thomas">Gilles D. Thomas</name><affiliation><nlm:aff id="A40">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N." last="Hoover">Robert N. Hoover</name><affiliation><nlm:aff id="A40">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A63">Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gibson, Lorna J" sort="Gibson, Lorna J" uniqKey="Gibson L" first="Lorna J." last="Gibson">Lorna J. Gibson</name><affiliation><nlm:aff id="A64">London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Silva, Isabel Dos Santos" sort="Silva, Isabel Dos Santos" uniqKey="Silva I" first="Isabel Dos Santos" last="Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="A64">London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="A64">London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Nickels, Stefan" sort="Nickels, Stefan" uniqKey="Nickels S" first="Stefan" last="Nickels">Stefan Nickels</name><affiliation><nlm:aff id="A9">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A65">Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A66">Department of Epidemiology, University of California Irvine, Irvine, California, USA</nlm:aff></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation><nlm:aff id="A66">Department of Epidemiology, University of California Irvine, Irvine, California, USA</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor" sort="Sawyer, Elinor" uniqKey="Sawyer E" first="Elinor" last="Sawyer">Elinor Sawyer</name><affiliation><nlm:aff id="A67">Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="A68">Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name><affiliation><nlm:aff id="A69">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="A69">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A70">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="A70">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Veer, Laura J" sort="Van Veer, Laura J" uniqKey="Van Veer L" first="Laura J." last="Van Veer">Laura J. Van Veer</name><affiliation><nlm:aff id="A70">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Rob A E M" sort="Tollenaar, Rob A E M" uniqKey="Tollenaar R" first="Rob A. E. M." last="Tollenaar">Rob A. E. M. Tollenaar</name><affiliation><nlm:aff id="A71">Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="A72">Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A72">Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name><affiliation><nlm:aff id="A73">Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="A59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A61">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation><nlm:aff id="A59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A61">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><affiliation><nlm:aff id="A59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="A11">Molecular Epidemiology Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A75">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A75">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="A75">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="A75">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name><affiliation><nlm:aff id="A77">Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Yoo, Keun Young" sort="Yoo, Keun Young" uniqKey="Yoo K" first="Keun-Young" last="Yoo">Keun-Young Yoo</name><affiliation><nlm:aff id="A77">Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Noh, Dong Young" sort="Noh, Dong Young" uniqKey="Noh D" first="Dong-Young" last="Noh">Dong-Young Noh</name><affiliation><nlm:aff id="A77">Seoul National University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Ahn, Sei Hyun" sort="Ahn, Sei Hyun" uniqKey="Ahn S" first="Sei-Hyun" last="Ahn">Sei-Hyun Ahn</name><affiliation><nlm:aff id="A78">Ulsan University College of Medicine, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A79">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name><affiliation><nlm:aff id="A80">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A79">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation><nlm:aff id="A79">Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation><nlm:aff id="A82">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A82">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A12">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Harth, Volker" sort="Harth, Volker" uniqKey="Harth V" first="Volker" last="Harth">Volker Harth</name><affiliation><nlm:aff id="A83">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name><affiliation><nlm:aff id="A84">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A85">University of Tübingen, Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A86">Laboratory of Cancer Genetics, Department of Clinical Genetics, Oulu University Hospital, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Biocenter Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="A86">Laboratory of Cancer Genetics, Department of Clinical Genetics, Oulu University Hospital, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Biocenter Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="A88">Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name><affiliation><nlm:aff id="A89">Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje" sort="Hooning, Maartje" uniqKey="Hooning M" first="Maartje" last="Hooning">Maartje Hooning</name><affiliation><nlm:aff id="A90">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="A91">Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Oldenburg, Rogier A" sort="Oldenburg, Rogier A" uniqKey="Oldenburg R" first="Rogier A." last="Oldenburg">Rogier A. Oldenburg</name><affiliation><nlm:aff id="A92">Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tilanus Linthorst, Madeleine" sort="Tilanus Linthorst, Madeleine" uniqKey="Tilanus Linthorst M" first="Madeleine" last="Tilanus-Linthorst">Madeleine Tilanus-Linthorst</name><affiliation><nlm:aff id="A93">Department of Surgical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name><affiliation><nlm:aff id="A94">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Bermisheva, Marina" sort="Bermisheva, Marina" uniqKey="Bermisheva M" first="Marina" last="Bermisheva">Marina Bermisheva</name><affiliation><nlm:aff id="A94">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Prokofieva, Darya" sort="Prokofieva, Darya" uniqKey="Prokofieva D" first="Darya" last="Prokofieva">Darya Prokofieva</name><affiliation><nlm:aff id="A94">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Farahtdinova, Albina" sort="Farahtdinova, Albina" uniqKey="Farahtdinova A" first="Albina" last="Farahtdinova">Albina Farahtdinova</name><affiliation><nlm:aff id="A94">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="A5">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="A6">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Manjeet K" sort="Humphreys, Manjeet K" uniqKey="Humphreys M" first="Manjeet K." last="Humphreys">Manjeet K. Humphreys</name><affiliation><nlm:aff id="A74">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="A74">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A82">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A73">Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">The single nucleotide polymorphism 5p12-rs10941679has been found to be associated with risk of breast cancer, particularly estrogen receptor (ER)-positive disease. We aimed to further explore this association overall, and by tumor histopathology, in the Breast Cancer Association Consortium.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Data were combined from 37 studies, including 40,972 invasive cases, 1,398 cases of ductal carcinoma in situ (DCIS) and 46,334 controls, all of white European ancestry, as well as 3,007 invasive cases and 2,337 controls of Asian ancestry. Associations overall and by tumor invasiveness and histopathology were assessed using logistic regression.</p></sec><sec id="S3"><title>Results</title><p id="P3">For white Europeans, the per-allele odds ratio (OR) associated with 5p12-rs10941679 was 1.11 (95% confidence interval [CI] =1.08–1.14, <italic>P</italic>=7×10<sup>−18</sup>) for invasive breast cancer and 1.10 (95%CI=1.01–1.21, <italic>P</italic>=0.03) for DCIS. For Asian women, the estimated OR for invasive disease was similar (OR=1.07, 95%CI=0.99–1.15, <italic>P</italic>=0.09). Further analyses suggested that the association in white Europeans was largely limited to progesterone receptor (PR)-positive disease (per-allele OR=1.16, 95%CI=1.12–1.20, <italic>P</italic>=1×10<sup>−18</sup> versus OR=1.03, 95%CI=0.99–1.07, <italic>P=</italic>0.2 for PR-negative disease; <italic>P</italic>-heterogeneity=2×10<sup>−7</sup>); heterogeneity by estrogen receptor status was not observed (<italic>P</italic>=0.2) once PR status was accounted for. The association was also stronger for lower-grade tumors (per-allele OR [95%CI]=1.20 [1.14–1.25], 1.13 [1.09–1.16] and 1.04 [0.99–1.08] for grade 1, 2 and 3/4, respectively; <italic>P</italic>–trend=5×10<sup>−7</sup>).</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">5p12 is a breast cancer susceptibility locus for PR-positive, lower gradebreast cancer.</p></sec><sec id="S5"><title>Impact</title><p id="P5">Multi-centre fine-mapping studies of this region are needed as a first step to identifying the causal variant or variants.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9200608</journal-id><journal-id journal-id-type="pubmed-jr-id">2299</journal-id><journal-id journal-id-type="nlm-ta">Cancer Epidemiol Biomarkers Prev</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Epidemiol. Biomarkers Prev.</journal-id><journal-title-group><journal-title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</journal-title></journal-title-group><issn pub-type="ppub">1055-9965</issn><issn pub-type="epub">1538-7755</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21795498</article-id><article-id pub-id-type="pmc">4164116</article-id><article-id pub-id-type="doi">10.1158/1055-9965.EPI-11-0569</article-id><article-id pub-id-type="manuscript">NIHMS493090</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Milne</surname><given-names>Roger L.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Goode</surname><given-names>Ellen L.</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>García-Closas</surname><given-names>Montserrat</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Severi</surname><given-names>Gianluca</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Hein</surname><given-names>Rebecca</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Fredericksen</surname><given-names>Zachary</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Malats</surname><given-names>Núria</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zamora</surname><given-names>M. 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contrib-type="author"><name><surname>Jakubowska</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="A75">75</xref></contrib><contrib contrib-type="author"><name><surname>Lubinski</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="A75">75</xref></contrib><contrib contrib-type="author"><name><surname>Jaworska</surname><given-names>Katarzyna</given-names></name><xref ref-type="aff" rid="A75">75</xref><xref ref-type="aff" rid="A76">76</xref></contrib><contrib contrib-type="author"><name><surname>Durda</surname><given-names>Katarzyna</given-names></name><xref ref-type="aff" rid="A75">75</xref></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>Daehee</given-names></name><xref ref-type="aff" rid="A77">77</xref></contrib><contrib contrib-type="author"><name><surname>Yoo</surname><given-names>Keun-Young</given-names></name><xref ref-type="aff" rid="A77">77</xref></contrib><contrib 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rid="A79">79</xref><xref ref-type="aff" rid="A80">80</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Xiaoqing</given-names></name><xref ref-type="aff" rid="A82">82</xref></contrib><contrib contrib-type="author"><name><surname>Beesley</surname><given-names>Jonathan</given-names></name><xref ref-type="aff" rid="A82">82</xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Harth</surname><given-names>Volker</given-names></name><xref ref-type="aff" rid="A83">83</xref></contrib><contrib contrib-type="author"><name><surname>Justenhoven</surname><given-names>Christina</given-names></name><xref ref-type="aff" rid="A84">84</xref><xref ref-type="aff" rid="A85">85</xref></contrib><contrib contrib-type="author"><name><surname>Winqvist</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="A86">86</xref><xref ref-type="aff" rid="A87">87</xref></contrib><contrib contrib-type="author"><name><surname>Pylkäs</surname><given-names>Katri</given-names></name><xref ref-type="aff" rid="A86">86</xref><xref ref-type="aff" rid="A87">87</xref></contrib><contrib contrib-type="author"><name><surname>Jukkola-Vuorinen</surname><given-names>Arja</given-names></name><xref ref-type="aff" rid="A88">88</xref></contrib><contrib contrib-type="author"><name><surname>Grip</surname><given-names>Mervi</given-names></name><xref ref-type="aff" rid="A89">89</xref></contrib><contrib contrib-type="author"><name><surname>Hooning</surname><given-names>Maartje</given-names></name><xref ref-type="aff" rid="A90">90</xref></contrib><contrib contrib-type="author"><name><surname>Hollestelle</surname><given-names>Antoinette</given-names></name><xref ref-type="aff" rid="A91">91</xref></contrib><contrib contrib-type="author"><name><surname>Oldenburg</surname><given-names>Rogier A.</given-names></name><xref ref-type="aff" rid="A92">92</xref></contrib><contrib contrib-type="author"><name><surname>Tilanus-Linthorst</surname><given-names>Madeleine</given-names></name><xref ref-type="aff" rid="A93">93</xref></contrib><contrib contrib-type="author"><name><surname>Khusnutdinova</surname><given-names>Elza</given-names></name><xref ref-type="aff" rid="A94">94</xref></contrib><contrib contrib-type="author"><name><surname>Bermisheva</surname><given-names>Marina</given-names></name><xref ref-type="aff" rid="A94">94</xref></contrib><contrib contrib-type="author"><name><surname>Prokofieva</surname><given-names>Darya</given-names></name><xref ref-type="aff" rid="A94">94</xref></contrib><contrib contrib-type="author"><name><surname>Farahtdinova</surname><given-names>Albina</given-names></name><xref ref-type="aff" rid="A94">94</xref></contrib><contrib contrib-type="author"><name><surname>Olson</surname><given-names>Janet E.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Xianshu</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Humphreys</surname><given-names>Manjeet K.</given-names></name><xref ref-type="aff" rid="A74">74</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Qin</given-names></name><xref ref-type="aff" rid="A74">74</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="A82">82</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="A73">73</xref><xref ref-type="aff" rid="A74">74</xref></contrib><on-behalf-of>for the GENICA Network</on-behalf-of><on-behalf-of>for the kConFab Investigators and the AOCS Group</on-behalf-of></contrib-group><aff id="A1"><label>1</label>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</aff><aff id="A2"><label>2</label>Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</aff><aff id="A3"><label>3</label>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Australia</aff><aff id="A4"><label>4</label>Department of Pathology, The University of Melbourne, Australia</aff><aff id="A5"><label>5</label>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</aff><aff id="A6"><label>6</label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</aff><aff id="A7"><label>7</label>Sections of Epidemiology and Genetics, Institute of Cancer Research and Breakthrough Breast Cancer Research Centre, London, UK</aff><aff id="A8"><label>8</label>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia</aff><aff id="A9"><label>9</label>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A10"><label>10</label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A11"><label>11</label>Molecular Epidemiology Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A12"><label>12</label>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A13"><label>13</label>Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</aff><aff id="A14"><label>14</label>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</aff><aff id="A15"><label>15</label>Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</aff><aff id="A16"><label>16</label>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</aff><aff id="A17"><label>17</label>Institute for Cancer Studies, Department of Oncology, University of Sheffield, UK</aff><aff id="A18"><label>18</label>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, UK</aff><aff id="A19"><label>19</label>University of Manchester, Manchester, UK</aff><aff id="A20"><label>20</label>Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK</aff><aff id="A21"><label>21</label>Institute of Biomedical Sciences, Academia Sinica, and Taiwan Biobank, Taipei, Taiwan</aff><aff id="A22"><label>22</label>Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan</aff><aff id="A23"><label>23</label>Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan</aff><aff id="A24"><label>24</label>Cancer Center and Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</aff><aff id="A25"><label>25</label>Copenhagen General Population Study and Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A26"><label>26</label>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A27"><label>27</label>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</aff><aff id="A28"><label>28</label>Faculty of Medicine (Faculty Division Ahus), UiO, Norway</aff><aff id="A29"><label>29</label>Vesalius Research Center (VRC), VIB, Leuven, Belgium</aff><aff id="A30"><label>30</label>Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium</aff><aff id="A31"><label>31</label>National Cancer Institute, Bangkok, Thailand</aff><aff id="A32"><label>32</label>International Agency for Research on Cancer, Lyon, France</aff><aff id="A33"><label>33</label>Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</aff><aff id="A34"><label>34</label>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</aff><aff id="A35"><label>35</label>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</aff><aff id="A36"><label>36</label>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</aff><aff id="A37"><label>37</label>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy</aff><aff id="A38"><label>38</label>Cancer Prevention Institute of California, Fremont and Stanford University School of Medicine, Stanford, California, USA</aff><aff id="A39"><label>39</label>Dana-Farber Cancer Institute, Boston, Massachusetts, USA</aff><aff id="A40"><label>40</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</aff><aff id="A41"><label>41</label>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland</aff><aff id="A42"><label>42</label>N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</aff><aff id="A43"><label>43</label>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany</aff><aff id="A44"><label>44</label>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, CA, USA</aff><aff id="A45"><label>45</label>Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany</aff><aff id="A46"><label>46</label>Saarland Cancer Registry, Saarbrücken, Germany</aff><aff id="A47"><label>47</label>Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, ON, Canada</aff><aff id="A48"><label>48</label>Fred A. Litwin Center for Cancer Genetics, Mount Sinai Hospital, Toronto, ON, Canada</aff><aff id="A49"><label>49</label>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada</aff><aff id="A50"><label>50</label>Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada</aff><aff id="A51"><label>51</label>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada</aff><aff id="A52"><label>52</label>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</aff><aff id="A53"><label>53</label>Department of Laboratory Medicine and Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, ON, Canada</aff><aff id="A54"><label>54</label>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</aff><aff id="A55"><label>55</label>Biocenter Kuopio, Kuopio Finland</aff><aff id="A56"><label>56</label>Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A57"><label>57</label>Department of Oncology, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A58"><label>58</label>Division of Gynecology and Obstetrics, Klinikum rechts der Isar at the Technical University Munich, Munich, Germany</aff><aff id="A59"><label>59</label>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</aff><aff id="A60"><label>60</label>Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany</aff><aff id="A61"><label>61</label>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</aff><aff id="A62"><label>62</label>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Center of Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany</aff><aff id="A63"><label>63</label>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK</aff><aff id="A64"><label>64</label>London School of Hygiene and Tropical Medicine, London, UK</aff><aff id="A65"><label>65</label>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</aff><aff id="A66"><label>66</label>Department of Epidemiology, University of California Irvine, Irvine, California, USA</aff><aff id="A67"><label>67</label>Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London, London, UK</aff><aff id="A68"><label>68</label>Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, UK</aff><aff id="A69"><label>69</label>Clinical Science Institute, University Hospital Galway, Galway, Ireland</aff><aff id="A70"><label>70</label>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</aff><aff id="A71"><label>71</label>Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A72"><label>72</label>Department of Oncology, University of Cambridge, Cambridge, UK</aff><aff id="A73"><label>73</label>Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff><aff id="A74"><label>74</label>Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK</aff><aff id="A75"><label>75</label>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff><aff id="A76"><label>76</label>Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland</aff><aff id="A77"><label>77</label>Seoul National University College of Medicine, Seoul, Korea</aff><aff id="A78"><label>78</label>Ulsan University College of Medicine, Seoul, Korea</aff><aff id="A79"><label>79</label>Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA</aff><aff id="A80"><label>80</label>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</aff><aff id="A81"><label>81</label>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</aff><aff id="A82"><label>82</label>Queensland Institute of Medical Research, Brisbane, Australia</aff><aff id="A83"><label>83</label>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany</aff><aff id="A84"><label>84</label>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</aff><aff id="A85"><label>85</label>University of Tübingen, Tübingen, Germany</aff><aff id="A86"><label>86</label>Laboratory of Cancer Genetics, Department of Clinical Genetics, Oulu University Hospital, University of Oulu, Oulu, Finland</aff><aff id="A87"><label>87</label>Biocenter Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland</aff><aff id="A88"><label>88</label>Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland</aff><aff id="A89"><label>89</label>Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland</aff><aff id="A90"><label>90</label>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A91"><label>91</label>Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A92"><label>92</label>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A93"><label>93</label>Department of Surgical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A94"><label>94</label>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia</aff><author-notes><corresp id="FN1">Corresponding author: Roger L. Milne, Genetic & Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain (<email>rmilne@cnio.es</email>)</corresp><fn id="FN2" fn-type="equal"><label>*</label><p>Contributed equally to this work</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>8</day><month>9</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>27</day><month>7</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>9</month><year>2014</year></pub-date><volume>20</volume><issue>10</issue><fpage>2222</fpage><lpage>2231</lpage><pmc-comment>elocation-id from pubmed: 10.1158/1055-9965.EPI-11-0569</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">The single nucleotide polymorphism 5p12-rs10941679has been found to be associated with risk of breast cancer, particularly estrogen receptor (ER)-positive disease. We aimed to further explore this association overall, and by tumor histopathology, in the Breast Cancer Association Consortium.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Data were combined from 37 studies, including 40,972 invasive cases, 1,398 cases of ductal carcinoma in situ (DCIS) and 46,334 controls, all of white European ancestry, as well as 3,007 invasive cases and 2,337 controls of Asian ancestry. Associations overall and by tumor invasiveness and histopathology were assessed using logistic regression.</p></sec><sec id="S3"><title>Results</title><p id="P3">For white Europeans, the per-allele odds ratio (OR) associated with 5p12-rs10941679 was 1.11 (95% confidence interval [CI] =1.08–1.14, <italic>P</italic>=7×10<sup>−18</sup>) for invasive breast cancer and 1.10 (95%CI=1.01–1.21, <italic>P</italic>=0.03) for DCIS. For Asian women, the estimated OR for invasive disease was similar (OR=1.07, 95%CI=0.99–1.15, <italic>P</italic>=0.09). Further analyses suggested that the association in white Europeans was largely limited to progesterone receptor (PR)-positive disease (per-allele OR=1.16, 95%CI=1.12–1.20, <italic>P</italic>=1×10<sup>−18</sup> versus OR=1.03, 95%CI=0.99–1.07, <italic>P=</italic>0.2 for PR-negative disease; <italic>P</italic>-heterogeneity=2×10<sup>−7</sup>); heterogeneity by estrogen receptor status was not observed (<italic>P</italic>=0.2) once PR status was accounted for. The association was also stronger for lower-grade tumors (per-allele OR [95%CI]=1.20 [1.14–1.25], 1.13 [1.09–1.16] and 1.04 [0.99–1.08] for grade 1, 2 and 3/4, respectively; <italic>P</italic>–trend=5×10<sup>−7</sup>).</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">5p12 is a breast cancer susceptibility locus for PR-positive, lower gradebreast cancer.</p></sec><sec id="S5"><title>Impact</title><p id="P5">Multi-centre fine-mapping studies of this region are needed as a first step to identifying the causal variant or variants.</p></sec></abstract><kwd-group><kwd>Breast cancer</kwd><kwd>SNP</kwd><kwd>susceptibility</kwd><kwd>disease subtypes</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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