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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Expansion of signal transduction pathways in fungi by extensive genome duplication</title><author><name sortKey="Corrochano, Luis M" sort="Corrochano, Luis M" uniqKey="Corrochano L" first="Luis M." last="Corrochano">Luis M. Corrochano</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Kuo, Alan" sort="Kuo, Alan" uniqKey="Kuo A" first="Alan" last="Kuo">Alan Kuo</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="Marcet Houben, Marina" sort="Marcet Houben, Marina" uniqKey="Marcet Houben M" first="Marina" last="Marcet-Houben">Marina Marcet-Houben</name><affiliation><nlm:aff id="A3">Centre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Universitat Pompeu Fabra (UPF), Doctor Aiguader 88, 08003 Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Polaino, Silvia" sort="Polaino, Silvia" uniqKey="Polaino S" first="Silvia" last="Polaino">Silvia Polaino</name><affiliation><nlm:aff id="A5">School of Biological Sciences, University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO 64110, USA</nlm:aff></affiliation></author><author><name sortKey="Salamov, Asaf" sort="Salamov, Asaf" uniqKey="Salamov A" first="Asaf" last="Salamov">Asaf Salamov</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="Villalobos Escobedo, Jose M" sort="Villalobos Escobedo, Jose M" uniqKey="Villalobos Escobedo J" first="José M." last="Villalobos-Escobedo">José M. Villalobos-Escobedo</name><affiliation><nlm:aff id="A6">Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, México</nlm:aff></affiliation></author><author><name sortKey="Grimwood, Jane" sort="Grimwood, Jane" uniqKey="Grimwood J" first="Jane" last="Grimwood">Jane Grimwood</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7">HudsonAlpha Institute of Biotechnology, 601 Genome Way Northwest, Huntsville, AL 35806, USA</nlm:aff></affiliation></author><author><name sortKey="Alvarez, M Isabel" sort="Alvarez, M Isabel" uniqKey="Alvarez M" first="M. Isabel" last="Álvarez">M. Isabel Álvarez</name><affiliation><nlm:aff id="A8">Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Avalos, Javier" sort="Avalos, Javier" uniqKey="Avalos J" first="Javier" last="Avalos">Javier Avalos</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Bauer, Diane" sort="Bauer, Diane" uniqKey="Bauer D" first="Diane" last="Bauer">Diane Bauer</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="Benito, Ernesto P" sort="Benito, Ernesto P" uniqKey="Benito E" first="Ernesto P." last="Benito">Ernesto P. Benito</name><affiliation><nlm:aff id="A8">Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Instituto Hispano-Luso de Investigaciones Agrarias (CIALE), Universidad de Salamanca, Río Duero 12, 37185 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Benoit, Isabelle" sort="Benoit, Isabelle" uniqKey="Benoit I" first="Isabelle" last="Benoit">Isabelle Benoit</name><affiliation><nlm:aff id="A10">CBS-KNAW Fungal Biodiversity Centre & Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Burger, Gertraud" sort="Burger, Gertraud" uniqKey="Burger G" first="Gertraud" last="Burger">Gertraud Burger</name><affiliation><nlm:aff id="A11">Universite de Montreal, Pavillon Roger-Gaudry, Biochimie, CP 6128, Succursale Centre-Ville, Montreal QC, H3C 3J7, Canada</nlm:aff></affiliation></author><author><name sortKey="Camino, Lola P" sort="Camino, Lola P" uniqKey="Camino L" first="Lola P." last="Camino">Lola P. Camino</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Canovas, David" sort="Canovas, David" uniqKey="Canovas D" first="David" last="Cánovas">David Cánovas</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Cerda Olmedo, Enrique" sort="Cerda Olmedo, Enrique" uniqKey="Cerda Olmedo E" first="Enrique" last="Cerdá-Olmedo">Enrique Cerdá-Olmedo</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Cheng, Jan Fang" sort="Cheng, Jan Fang" uniqKey="Cheng J" first="Jan-Fang" last="Cheng">Jan-Fang Cheng</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="Dominguez, Angel" sort="Dominguez, Angel" uniqKey="Dominguez A" first="Angel" last="Domínguez">Angel Domínguez</name><affiliation><nlm:aff id="A8">Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Elias, Marek" sort="Elias, Marek" uniqKey="Elias M" first="Marek" last="Eliáš">Marek Eliáš</name><affiliation><nlm:aff id="A12">Department of Biology and Ecology, Faculty of Science, University of Ostrava, Chittussiho 10, 710 00 Ostrava, Czech Republic</nlm:aff></affiliation></author><author><name sortKey="Eslava, Arturo P" sort="Eslava, Arturo P" uniqKey="Eslava A" first="Arturo P." last="Eslava">Arturo P. Eslava</name><affiliation><nlm:aff id="A8">Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Glaser, Fabian" sort="Glaser, Fabian" uniqKey="Glaser F" first="Fabian" last="Glaser">Fabian Glaser</name><affiliation><nlm:aff id="A13">Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion - Israel Institute of Technology, Haifa 3200003, Israel</nlm:aff></affiliation></author><author><name sortKey="Gutierrez, Gabriel" sort="Gutierrez, Gabriel" uniqKey="Gutierrez G" first="Gabriel" last="Gutiérrez">Gabriel Gutiérrez</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Heitman, Joseph" sort="Heitman, Joseph" uniqKey="Heitman J" first="Joseph" last="Heitman">Joseph Heitman</name><affiliation><nlm:aff id="A14">Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA</nlm:aff></affiliation></author><author><name sortKey="Henrissat, Bernard" sort="Henrissat, Bernard" uniqKey="Henrissat B" first="Bernard" last="Henrissat">Bernard Henrissat</name><affiliation><nlm:aff id="A15">Centre National de la Recherche Scientifique (CNRS), UMR7257, Université Aix-Marseille, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Biological Sciences, King Abdulaziz University, P.O Box 80203, Jeddah 21589, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Iturriaga, Enrique A" sort="Iturriaga, Enrique A" uniqKey="Iturriaga E" first="Enrique A." last="Iturriaga">Enrique A. Iturriaga</name><affiliation><nlm:aff id="A8">Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Lang, B Franz" sort="Lang, B Franz" uniqKey="Lang B" first="B. Franz" last="Lang">B. Franz Lang</name><affiliation><nlm:aff id="A11">Universite de Montreal, Pavillon Roger-Gaudry, Biochimie, CP 6128, Succursale Centre-Ville, Montreal QC, H3C 3J7, Canada</nlm:aff></affiliation></author><author><name sortKey="Lavin, Jose L" sort="Lavin, Jose L" uniqKey="Lavin J" first="José L." last="Lavín">José L. Lavín</name><affiliation><nlm:aff id="A17">Genome Analysis Platform, CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Bizkaia, Spain</nlm:aff></affiliation></author><author><name sortKey="Lee, Soo Chan" sort="Lee, Soo Chan" uniqKey="Lee S" first="Soo Chan" last="Lee">Soo Chan Lee</name><affiliation><nlm:aff id="A14">Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Wenjun" sort="Li, Wenjun" uniqKey="Li W" first="Wenjun" last="Li">Wenjun Li</name><affiliation><nlm:aff id="A14">Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA</nlm:aff></affiliation></author><author><name sortKey="Lindquist, Erika" sort="Lindquist, Erika" uniqKey="Lindquist E" first="Erika" last="Lindquist">Erika Lindquist</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="L Pez Garcia, Sergio" sort="L Pez Garcia, Sergio" uniqKey="L Pez Garcia S" first="Sergio" last="L Pez-García">Sergio L Pez-García</name><affiliation><nlm:aff id="A18">Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain</nlm:aff></affiliation></author><author><name sortKey="Luque, Eva M" sort="Luque, Eva M" uniqKey="Luque E" first="Eva M." last="Luque">Eva M. Luque</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Marcos, Ana T" sort="Marcos, Ana T" uniqKey="Marcos A" first="Ana T." last="Marcos">Ana T. Marcos</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Martin, Joel" sort="Martin, Joel" uniqKey="Martin J" first="Joel" last="Martin">Joel Martin</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="Mccluskey, Kevin" sort="Mccluskey, Kevin" uniqKey="Mccluskey K" first="Kevin" last="Mccluskey">Kevin Mccluskey</name><affiliation><nlm:aff id="A19">Department of Plant Pathology, Kansas State University, 4024 Throckmorton Plant Sciences Center, Manhattan, KS 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Medina, Humberto R" sort="Medina, Humberto R" uniqKey="Medina H" first="Humberto R." last="Medina">Humberto R. Medina</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Miralles Duran, Alejandro" sort="Miralles Duran, Alejandro" uniqKey="Miralles Duran A" first="Alejandro" last="Miralles-Durán">Alejandro Miralles-Durán</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Miyazaki, Atsushi" sort="Miyazaki, Atsushi" uniqKey="Miyazaki A" first="Atsushi" last="Miyazaki">Atsushi Miyazaki</name><affiliation><nlm:aff id="A20">Department of Biological Sciences, Faculty of Science and Engineering, Ishinomaki Senshu University, Ishinomaki 986-8580, Japan</nlm:aff></affiliation></author><author><name sortKey="Mu Oz Torres, Elisa" sort="Mu Oz Torres, Elisa" uniqKey="Mu Oz Torres E" first="Elisa" last="Mu Oz-Torres">Elisa Mu Oz-Torres</name><affiliation><nlm:aff id="A21">Departamento de Biología Celular y Patología, Facultad de Medicina, Universidad de Salamanca, Avda. Campus Miguel de Unamuno, 37007 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Oguiza, Jose A" sort="Oguiza, Jose A" uniqKey="Oguiza J" first="José A." last="Oguiza">José A. Oguiza</name><affiliation><nlm:aff id="A22">Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain</nlm:aff></affiliation></author><author><name sortKey="Ohm, Robin A" sort="Ohm, Robin A" uniqKey="Ohm R" first="Robin A." last="Ohm">Robin A. Ohm</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="Orejas, Margarita" sort="Orejas, Margarita" uniqKey="Orejas M" first="Margarita" last="Orejas">Margarita Orejas</name><affiliation><nlm:aff id="A23">Instituto de Agroquímica y Tecnología de Alimentos, Consejo Superior de Investigaciones Científicas (IATA-CSIC), Avda. Catedrático Agustín Escardino 7, 46980 Paterna, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Ortiz Castellanos, Lucila" sort="Ortiz Castellanos, Lucila" uniqKey="Ortiz Castellanos L" first="Lucila" last="Ortiz-Castellanos">Lucila Ortiz-Castellanos</name><affiliation><nlm:aff id="A24">Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, Mexico</nlm:aff></affiliation></author><author><name sortKey="Pisabarro, Antonio G" sort="Pisabarro, Antonio G" uniqKey="Pisabarro A" first="Antonio G." last="Pisabarro">Antonio G. Pisabarro</name><affiliation><nlm:aff id="A22">Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain</nlm:aff></affiliation></author><author><name sortKey="Rodriguez Romero, Julio" sort="Rodriguez Romero, Julio" uniqKey="Rodriguez Romero J" first="Julio" last="Rodríguez-Romero">Julio Rodríguez-Romero</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Ruiz Herrera, Jose" sort="Ruiz Herrera, Jose" uniqKey="Ruiz Herrera J" first="José" last="Ruiz-Herrera">José Ruiz-Herrera</name><affiliation><nlm:aff id="A24">Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, Mexico</nlm:aff></affiliation></author><author><name sortKey="Ruiz Vazquez, Rosa" sort="Ruiz Vazquez, Rosa" uniqKey="Ruiz Vazquez R" first="Rosa" last="Ruiz-Vázquez">Rosa Ruiz-Vázquez</name><affiliation><nlm:aff id="A18">Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain</nlm:aff></affiliation></author><author><name sortKey="Sanz, Catalina" sort="Sanz, Catalina" uniqKey="Sanz C" first="Catalina" last="Sanz">Catalina Sanz</name><affiliation><nlm:aff id="A8">Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Schackwitz, Wendy" sort="Schackwitz, Wendy" uniqKey="Schackwitz W" first="Wendy" last="Schackwitz">Wendy Schackwitz</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="Shahriari, Mahdi" sort="Shahriari, Mahdi" uniqKey="Shahriari M" first="Mahdi" last="Shahriari">Mahdi Shahriari</name><affiliation><nlm:aff id="A8">Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Shelest, Ekaterina" sort="Shelest, Ekaterina" uniqKey="Shelest E" first="Ekaterina" last="Shelest">Ekaterina Shelest</name><affiliation><nlm:aff id="A25">Leibniz Institute for Natural Product Research and Infection Biology (Hans Knoell Institute), Beutenbergstr. 11a, 07745 Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Silva Franco, Fatima" sort="Silva Franco, Fatima" uniqKey="Silva Franco F" first="Fátima" last="Silva-Franco">Fátima Silva-Franco</name><affiliation><nlm:aff id="A18">Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain</nlm:aff></affiliation></author><author><name sortKey="Soanes, Darren" sort="Soanes, Darren" uniqKey="Soanes D" first="Darren" last="Soanes">Darren Soanes</name><affiliation><nlm:aff id="A26">Biosciences, College of Life & Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4QD, UK</nlm:aff></affiliation></author><author><name sortKey="Syed, Khajamohiddin" sort="Syed, Khajamohiddin" uniqKey="Syed K" first="Khajamohiddin" last="Syed">Khajamohiddin Syed</name><affiliation><nlm:aff id="A27">Department of Environmental Health, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267-0056, USA</nlm:aff></affiliation></author><author><name sortKey="Tagua, Victor G" sort="Tagua, Victor G" uniqKey="Tagua V" first="Víctor G." last="Tagua">Víctor G. Tagua</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Talbot, Nicholas J" sort="Talbot, Nicholas J" uniqKey="Talbot N" first="Nicholas J." last="Talbot">Nicholas J. Talbot</name><affiliation><nlm:aff id="A26">Biosciences, College of Life & Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4QD, UK</nlm:aff></affiliation></author><author><name sortKey="Thon, Michael R" sort="Thon, Michael R" uniqKey="Thon M" first="Michael R." last="Thon">Michael R. Thon</name><affiliation><nlm:aff id="A8">Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Instituto Hispano-Luso de Investigaciones Agrarias (CIALE), Universidad de Salamanca, Río Duero 12, 37185 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Tice, Hope" sort="Tice, Hope" uniqKey="Tice H" first="Hope" last="Tice">Hope Tice</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="De Vries, Ronald P" sort="De Vries, Ronald P" uniqKey="De Vries R" first="Ronald P." last="De Vries">Ronald P. De Vries</name><affiliation><nlm:aff id="A10">CBS-KNAW Fungal Biodiversity Centre & Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wiebenga, Ad" sort="Wiebenga, Ad" uniqKey="Wiebenga A" first="Ad" last="Wiebenga">Ad Wiebenga</name><affiliation><nlm:aff id="A10">CBS-KNAW Fungal Biodiversity Centre & Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Yadav, Jagjit S" sort="Yadav, Jagjit S" uniqKey="Yadav J" first="Jagjit S." last="Yadav">Jagjit S. Yadav</name><affiliation><nlm:aff id="A27">Department of Environmental Health, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267-0056, USA</nlm:aff></affiliation></author><author><name sortKey="Braun, Edward L" sort="Braun, Edward L" uniqKey="Braun E" first="Edward L." last="Braun">Edward L. Braun</name><affiliation><nlm:aff id="A28">Department of Biology, University of Florida, Gainesville, P.O. Box 118525, FL 32611-8525, USA</nlm:aff></affiliation></author><author><name sortKey="Baker, Scott E" sort="Baker, Scott E" uniqKey="Baker S" first="Scott E." last="Baker">Scott E. Baker</name><affiliation><nlm:aff id="A29">Pacific Northwest National Laboratory, 902 Battelle Blvd., Richland, WA 99352, USA</nlm:aff></affiliation></author><author><name sortKey="Garre, Victoriano" sort="Garre, Victoriano" uniqKey="Garre V" first="Victoriano" last="Garre">Victoriano Garre</name><affiliation><nlm:aff id="A18">Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain</nlm:aff></affiliation></author><author><name sortKey="Schmutz, Jeremy" sort="Schmutz, Jeremy" uniqKey="Schmutz J" first="Jeremy" last="Schmutz">Jeremy Schmutz</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7">HudsonAlpha Institute of Biotechnology, 601 Genome Way Northwest, Huntsville, AL 35806, USA</nlm:aff></affiliation></author><author><name sortKey="Horwitz, Benjamin A" sort="Horwitz, Benjamin A" uniqKey="Horwitz B" first="Benjamin A." last="Horwitz">Benjamin A. Horwitz</name><affiliation><nlm:aff id="A30">Department of Biology, Technion - Israel Institute of Technology, Haifa 32000, Israel</nlm:aff></affiliation></author><author><name sortKey="Torres Martinez, Santiago" sort="Torres Martinez, Santiago" uniqKey="Torres Martinez S" first="Santiago" last="Torres-Martínez">Santiago Torres-Martínez</name><affiliation><nlm:aff id="A18">Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain</nlm:aff></affiliation></author><author><name sortKey="Idnurm, Alexander" sort="Idnurm, Alexander" uniqKey="Idnurm A" first="Alexander" last="Idnurm">Alexander Idnurm</name><affiliation><nlm:aff id="A5">School of Biological Sciences, University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO 64110, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A31">School of BioSciences, University of Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Herrera Estrella, Alfredo" sort="Herrera Estrella, Alfredo" uniqKey="Herrera Estrella A" first="Alfredo" last="Herrera-Estrella">Alfredo Herrera-Estrella</name><affiliation><nlm:aff id="A6">Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, México</nlm:aff></affiliation></author><author><name sortKey="Gabald N, Toni" sort="Gabald N, Toni" uniqKey="Gabald N T" first="Toni" last="Gabald N">Toni Gabald N</name><affiliation><nlm:aff id="A3">Centre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Universitat Pompeu Fabra (UPF), Doctor Aiguader 88, 08003 Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Grigoriev, Igor V" sort="Grigoriev, Igor V" uniqKey="Grigoriev I" first="Igor V." last="Grigoriev">Igor V. Grigoriev</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27238284</idno><idno type="pmc">5089372</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089372</idno><idno type="RBID">PMC:5089372</idno><idno type="doi">10.1016/j.cub.2016.04.038</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002077</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002077</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Expansion of signal transduction pathways in fungi by extensive genome duplication</title><author><name sortKey="Corrochano, Luis M" sort="Corrochano, Luis M" uniqKey="Corrochano L" first="Luis M." last="Corrochano">Luis M. Corrochano</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Kuo, Alan" sort="Kuo, Alan" uniqKey="Kuo A" first="Alan" last="Kuo">Alan Kuo</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="Marcet Houben, Marina" sort="Marcet Houben, Marina" uniqKey="Marcet Houben M" first="Marina" last="Marcet-Houben">Marina Marcet-Houben</name><affiliation><nlm:aff id="A3">Centre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Universitat Pompeu Fabra (UPF), Doctor Aiguader 88, 08003 Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Polaino, Silvia" sort="Polaino, Silvia" uniqKey="Polaino S" first="Silvia" last="Polaino">Silvia Polaino</name><affiliation><nlm:aff id="A5">School of Biological Sciences, University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO 64110, USA</nlm:aff></affiliation></author><author><name sortKey="Salamov, Asaf" sort="Salamov, Asaf" uniqKey="Salamov A" first="Asaf" last="Salamov">Asaf Salamov</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="Villalobos Escobedo, Jose M" sort="Villalobos Escobedo, Jose M" uniqKey="Villalobos Escobedo J" first="José M." last="Villalobos-Escobedo">José M. Villalobos-Escobedo</name><affiliation><nlm:aff id="A6">Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, México</nlm:aff></affiliation></author><author><name sortKey="Grimwood, Jane" sort="Grimwood, Jane" uniqKey="Grimwood J" first="Jane" last="Grimwood">Jane Grimwood</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7">HudsonAlpha Institute of Biotechnology, 601 Genome Way Northwest, Huntsville, AL 35806, USA</nlm:aff></affiliation></author><author><name sortKey="Alvarez, M Isabel" sort="Alvarez, M Isabel" uniqKey="Alvarez M" first="M. Isabel" last="Álvarez">M. Isabel Álvarez</name><affiliation><nlm:aff id="A8">Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Avalos, Javier" sort="Avalos, Javier" uniqKey="Avalos J" first="Javier" last="Avalos">Javier Avalos</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Bauer, Diane" sort="Bauer, Diane" uniqKey="Bauer D" first="Diane" last="Bauer">Diane Bauer</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="Benito, Ernesto P" sort="Benito, Ernesto P" uniqKey="Benito E" first="Ernesto P." last="Benito">Ernesto P. Benito</name><affiliation><nlm:aff id="A8">Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Instituto Hispano-Luso de Investigaciones Agrarias (CIALE), Universidad de Salamanca, Río Duero 12, 37185 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Benoit, Isabelle" sort="Benoit, Isabelle" uniqKey="Benoit I" first="Isabelle" last="Benoit">Isabelle Benoit</name><affiliation><nlm:aff id="A10">CBS-KNAW Fungal Biodiversity Centre & Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Burger, Gertraud" sort="Burger, Gertraud" uniqKey="Burger G" first="Gertraud" last="Burger">Gertraud Burger</name><affiliation><nlm:aff id="A11">Universite de Montreal, Pavillon Roger-Gaudry, Biochimie, CP 6128, Succursale Centre-Ville, Montreal QC, H3C 3J7, Canada</nlm:aff></affiliation></author><author><name sortKey="Camino, Lola P" sort="Camino, Lola P" uniqKey="Camino L" first="Lola P." last="Camino">Lola P. Camino</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Canovas, David" sort="Canovas, David" uniqKey="Canovas D" first="David" last="Cánovas">David Cánovas</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Cerda Olmedo, Enrique" sort="Cerda Olmedo, Enrique" uniqKey="Cerda Olmedo E" first="Enrique" last="Cerdá-Olmedo">Enrique Cerdá-Olmedo</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Cheng, Jan Fang" sort="Cheng, Jan Fang" uniqKey="Cheng J" first="Jan-Fang" last="Cheng">Jan-Fang Cheng</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="Dominguez, Angel" sort="Dominguez, Angel" uniqKey="Dominguez A" first="Angel" last="Domínguez">Angel Domínguez</name><affiliation><nlm:aff id="A8">Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Elias, Marek" sort="Elias, Marek" uniqKey="Elias M" first="Marek" last="Eliáš">Marek Eliáš</name><affiliation><nlm:aff id="A12">Department of Biology and Ecology, Faculty of Science, University of Ostrava, Chittussiho 10, 710 00 Ostrava, Czech Republic</nlm:aff></affiliation></author><author><name sortKey="Eslava, Arturo P" sort="Eslava, Arturo P" uniqKey="Eslava A" first="Arturo P." last="Eslava">Arturo P. Eslava</name><affiliation><nlm:aff id="A8">Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Glaser, Fabian" sort="Glaser, Fabian" uniqKey="Glaser F" first="Fabian" last="Glaser">Fabian Glaser</name><affiliation><nlm:aff id="A13">Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion - Israel Institute of Technology, Haifa 3200003, Israel</nlm:aff></affiliation></author><author><name sortKey="Gutierrez, Gabriel" sort="Gutierrez, Gabriel" uniqKey="Gutierrez G" first="Gabriel" last="Gutiérrez">Gabriel Gutiérrez</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Heitman, Joseph" sort="Heitman, Joseph" uniqKey="Heitman J" first="Joseph" last="Heitman">Joseph Heitman</name><affiliation><nlm:aff id="A14">Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA</nlm:aff></affiliation></author><author><name sortKey="Henrissat, Bernard" sort="Henrissat, Bernard" uniqKey="Henrissat B" first="Bernard" last="Henrissat">Bernard Henrissat</name><affiliation><nlm:aff id="A15">Centre National de la Recherche Scientifique (CNRS), UMR7257, Université Aix-Marseille, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Biological Sciences, King Abdulaziz University, P.O Box 80203, Jeddah 21589, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Iturriaga, Enrique A" sort="Iturriaga, Enrique A" uniqKey="Iturriaga E" first="Enrique A." last="Iturriaga">Enrique A. Iturriaga</name><affiliation><nlm:aff id="A8">Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Lang, B Franz" sort="Lang, B Franz" uniqKey="Lang B" first="B. Franz" last="Lang">B. Franz Lang</name><affiliation><nlm:aff id="A11">Universite de Montreal, Pavillon Roger-Gaudry, Biochimie, CP 6128, Succursale Centre-Ville, Montreal QC, H3C 3J7, Canada</nlm:aff></affiliation></author><author><name sortKey="Lavin, Jose L" sort="Lavin, Jose L" uniqKey="Lavin J" first="José L." last="Lavín">José L. Lavín</name><affiliation><nlm:aff id="A17">Genome Analysis Platform, CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Bizkaia, Spain</nlm:aff></affiliation></author><author><name sortKey="Lee, Soo Chan" sort="Lee, Soo Chan" uniqKey="Lee S" first="Soo Chan" last="Lee">Soo Chan Lee</name><affiliation><nlm:aff id="A14">Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Wenjun" sort="Li, Wenjun" uniqKey="Li W" first="Wenjun" last="Li">Wenjun Li</name><affiliation><nlm:aff id="A14">Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA</nlm:aff></affiliation></author><author><name sortKey="Lindquist, Erika" sort="Lindquist, Erika" uniqKey="Lindquist E" first="Erika" last="Lindquist">Erika Lindquist</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="L Pez Garcia, Sergio" sort="L Pez Garcia, Sergio" uniqKey="L Pez Garcia S" first="Sergio" last="L Pez-García">Sergio L Pez-García</name><affiliation><nlm:aff id="A18">Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain</nlm:aff></affiliation></author><author><name sortKey="Luque, Eva M" sort="Luque, Eva M" uniqKey="Luque E" first="Eva M." last="Luque">Eva M. Luque</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Marcos, Ana T" sort="Marcos, Ana T" uniqKey="Marcos A" first="Ana T." last="Marcos">Ana T. Marcos</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Martin, Joel" sort="Martin, Joel" uniqKey="Martin J" first="Joel" last="Martin">Joel Martin</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="Mccluskey, Kevin" sort="Mccluskey, Kevin" uniqKey="Mccluskey K" first="Kevin" last="Mccluskey">Kevin Mccluskey</name><affiliation><nlm:aff id="A19">Department of Plant Pathology, Kansas State University, 4024 Throckmorton Plant Sciences Center, Manhattan, KS 66506, USA</nlm:aff></affiliation></author><author><name sortKey="Medina, Humberto R" sort="Medina, Humberto R" uniqKey="Medina H" first="Humberto R." last="Medina">Humberto R. Medina</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Miralles Duran, Alejandro" sort="Miralles Duran, Alejandro" uniqKey="Miralles Duran A" first="Alejandro" last="Miralles-Durán">Alejandro Miralles-Durán</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Miyazaki, Atsushi" sort="Miyazaki, Atsushi" uniqKey="Miyazaki A" first="Atsushi" last="Miyazaki">Atsushi Miyazaki</name><affiliation><nlm:aff id="A20">Department of Biological Sciences, Faculty of Science and Engineering, Ishinomaki Senshu University, Ishinomaki 986-8580, Japan</nlm:aff></affiliation></author><author><name sortKey="Mu Oz Torres, Elisa" sort="Mu Oz Torres, Elisa" uniqKey="Mu Oz Torres E" first="Elisa" last="Mu Oz-Torres">Elisa Mu Oz-Torres</name><affiliation><nlm:aff id="A21">Departamento de Biología Celular y Patología, Facultad de Medicina, Universidad de Salamanca, Avda. Campus Miguel de Unamuno, 37007 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Oguiza, Jose A" sort="Oguiza, Jose A" uniqKey="Oguiza J" first="José A." last="Oguiza">José A. Oguiza</name><affiliation><nlm:aff id="A22">Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain</nlm:aff></affiliation></author><author><name sortKey="Ohm, Robin A" sort="Ohm, Robin A" uniqKey="Ohm R" first="Robin A." last="Ohm">Robin A. Ohm</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="Orejas, Margarita" sort="Orejas, Margarita" uniqKey="Orejas M" first="Margarita" last="Orejas">Margarita Orejas</name><affiliation><nlm:aff id="A23">Instituto de Agroquímica y Tecnología de Alimentos, Consejo Superior de Investigaciones Científicas (IATA-CSIC), Avda. Catedrático Agustín Escardino 7, 46980 Paterna, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Ortiz Castellanos, Lucila" sort="Ortiz Castellanos, Lucila" uniqKey="Ortiz Castellanos L" first="Lucila" last="Ortiz-Castellanos">Lucila Ortiz-Castellanos</name><affiliation><nlm:aff id="A24">Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, Mexico</nlm:aff></affiliation></author><author><name sortKey="Pisabarro, Antonio G" sort="Pisabarro, Antonio G" uniqKey="Pisabarro A" first="Antonio G." last="Pisabarro">Antonio G. Pisabarro</name><affiliation><nlm:aff id="A22">Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain</nlm:aff></affiliation></author><author><name sortKey="Rodriguez Romero, Julio" sort="Rodriguez Romero, Julio" uniqKey="Rodriguez Romero J" first="Julio" last="Rodríguez-Romero">Julio Rodríguez-Romero</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Ruiz Herrera, Jose" sort="Ruiz Herrera, Jose" uniqKey="Ruiz Herrera J" first="José" last="Ruiz-Herrera">José Ruiz-Herrera</name><affiliation><nlm:aff id="A24">Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, Mexico</nlm:aff></affiliation></author><author><name sortKey="Ruiz Vazquez, Rosa" sort="Ruiz Vazquez, Rosa" uniqKey="Ruiz Vazquez R" first="Rosa" last="Ruiz-Vázquez">Rosa Ruiz-Vázquez</name><affiliation><nlm:aff id="A18">Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain</nlm:aff></affiliation></author><author><name sortKey="Sanz, Catalina" sort="Sanz, Catalina" uniqKey="Sanz C" first="Catalina" last="Sanz">Catalina Sanz</name><affiliation><nlm:aff id="A8">Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Schackwitz, Wendy" sort="Schackwitz, Wendy" uniqKey="Schackwitz W" first="Wendy" last="Schackwitz">Wendy Schackwitz</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="Shahriari, Mahdi" sort="Shahriari, Mahdi" uniqKey="Shahriari M" first="Mahdi" last="Shahriari">Mahdi Shahriari</name><affiliation><nlm:aff id="A8">Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Shelest, Ekaterina" sort="Shelest, Ekaterina" uniqKey="Shelest E" first="Ekaterina" last="Shelest">Ekaterina Shelest</name><affiliation><nlm:aff id="A25">Leibniz Institute for Natural Product Research and Infection Biology (Hans Knoell Institute), Beutenbergstr. 11a, 07745 Jena, Germany</nlm:aff></affiliation></author><author><name sortKey="Silva Franco, Fatima" sort="Silva Franco, Fatima" uniqKey="Silva Franco F" first="Fátima" last="Silva-Franco">Fátima Silva-Franco</name><affiliation><nlm:aff id="A18">Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain</nlm:aff></affiliation></author><author><name sortKey="Soanes, Darren" sort="Soanes, Darren" uniqKey="Soanes D" first="Darren" last="Soanes">Darren Soanes</name><affiliation><nlm:aff id="A26">Biosciences, College of Life & Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4QD, UK</nlm:aff></affiliation></author><author><name sortKey="Syed, Khajamohiddin" sort="Syed, Khajamohiddin" uniqKey="Syed K" first="Khajamohiddin" last="Syed">Khajamohiddin Syed</name><affiliation><nlm:aff id="A27">Department of Environmental Health, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267-0056, USA</nlm:aff></affiliation></author><author><name sortKey="Tagua, Victor G" sort="Tagua, Victor G" uniqKey="Tagua V" first="Víctor G." last="Tagua">Víctor G. Tagua</name><affiliation><nlm:aff id="A1">Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Talbot, Nicholas J" sort="Talbot, Nicholas J" uniqKey="Talbot N" first="Nicholas J." last="Talbot">Nicholas J. Talbot</name><affiliation><nlm:aff id="A26">Biosciences, College of Life & Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4QD, UK</nlm:aff></affiliation></author><author><name sortKey="Thon, Michael R" sort="Thon, Michael R" uniqKey="Thon M" first="Michael R." last="Thon">Michael R. Thon</name><affiliation><nlm:aff id="A8">Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Instituto Hispano-Luso de Investigaciones Agrarias (CIALE), Universidad de Salamanca, Río Duero 12, 37185 Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Tice, Hope" sort="Tice, Hope" uniqKey="Tice H" first="Hope" last="Tice">Hope Tice</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author><author><name sortKey="De Vries, Ronald P" sort="De Vries, Ronald P" uniqKey="De Vries R" first="Ronald P." last="De Vries">Ronald P. De Vries</name><affiliation><nlm:aff id="A10">CBS-KNAW Fungal Biodiversity Centre & Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wiebenga, Ad" sort="Wiebenga, Ad" uniqKey="Wiebenga A" first="Ad" last="Wiebenga">Ad Wiebenga</name><affiliation><nlm:aff id="A10">CBS-KNAW Fungal Biodiversity Centre & Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Yadav, Jagjit S" sort="Yadav, Jagjit S" uniqKey="Yadav J" first="Jagjit S." last="Yadav">Jagjit S. Yadav</name><affiliation><nlm:aff id="A27">Department of Environmental Health, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267-0056, USA</nlm:aff></affiliation></author><author><name sortKey="Braun, Edward L" sort="Braun, Edward L" uniqKey="Braun E" first="Edward L." last="Braun">Edward L. Braun</name><affiliation><nlm:aff id="A28">Department of Biology, University of Florida, Gainesville, P.O. Box 118525, FL 32611-8525, USA</nlm:aff></affiliation></author><author><name sortKey="Baker, Scott E" sort="Baker, Scott E" uniqKey="Baker S" first="Scott E." last="Baker">Scott E. Baker</name><affiliation><nlm:aff id="A29">Pacific Northwest National Laboratory, 902 Battelle Blvd., Richland, WA 99352, USA</nlm:aff></affiliation></author><author><name sortKey="Garre, Victoriano" sort="Garre, Victoriano" uniqKey="Garre V" first="Victoriano" last="Garre">Victoriano Garre</name><affiliation><nlm:aff id="A18">Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain</nlm:aff></affiliation></author><author><name sortKey="Schmutz, Jeremy" sort="Schmutz, Jeremy" uniqKey="Schmutz J" first="Jeremy" last="Schmutz">Jeremy Schmutz</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7">HudsonAlpha Institute of Biotechnology, 601 Genome Way Northwest, Huntsville, AL 35806, USA</nlm:aff></affiliation></author><author><name sortKey="Horwitz, Benjamin A" sort="Horwitz, Benjamin A" uniqKey="Horwitz B" first="Benjamin A." last="Horwitz">Benjamin A. Horwitz</name><affiliation><nlm:aff id="A30">Department of Biology, Technion - Israel Institute of Technology, Haifa 32000, Israel</nlm:aff></affiliation></author><author><name sortKey="Torres Martinez, Santiago" sort="Torres Martinez, Santiago" uniqKey="Torres Martinez S" first="Santiago" last="Torres-Martínez">Santiago Torres-Martínez</name><affiliation><nlm:aff id="A18">Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain</nlm:aff></affiliation></author><author><name sortKey="Idnurm, Alexander" sort="Idnurm, Alexander" uniqKey="Idnurm A" first="Alexander" last="Idnurm">Alexander Idnurm</name><affiliation><nlm:aff id="A5">School of Biological Sciences, University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO 64110, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A31">School of BioSciences, University of Melbourne, VIC 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Herrera Estrella, Alfredo" sort="Herrera Estrella, Alfredo" uniqKey="Herrera Estrella A" first="Alfredo" last="Herrera-Estrella">Alfredo Herrera-Estrella</name><affiliation><nlm:aff id="A6">Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, México</nlm:aff></affiliation></author><author><name sortKey="Gabald N, Toni" sort="Gabald N, Toni" uniqKey="Gabald N T" first="Toni" last="Gabald N">Toni Gabald N</name><affiliation><nlm:aff id="A3">Centre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Universitat Pompeu Fabra (UPF), Doctor Aiguader 88, 08003 Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Grigoriev, Igor V" sort="Grigoriev, Igor V" uniqKey="Grigoriev I" first="Igor V." last="Grigoriev">Igor V. Grigoriev</name><affiliation><nlm:aff id="A2">U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Current biology : CB</title><idno type="ISSN">0960-9822</idno><idno type="eISSN">1879-0445</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p id="P1">Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus <italic>Phycomyces blakesleeanus</italic> are single cells that react to environmental cues, including light, but the mechanisms are largely unknown [<xref rid="R1" ref-type="bibr">1</xref>]. The related fungus <italic>Mucor circinelloides</italic> is an opportunistic human pathogen that changes its mode of growth upon receipt of signals from the environment to facilitate pathogenesis [<xref rid="R2" ref-type="bibr">2</xref>]. Understanding how these organisms respond to environmental cues should provide insights into the mechanisms of sensory perception and signal transduction by a single eukaryotic cell, and their role in pathogenesis. We sequenced the genomes of <italic>P. blakesleeanus</italic> and <italic>M. circinelloides</italic>, and show that they have been shaped by an extensive genome duplication or, most likely, a whole genome duplication (WGD), which is rarely observed in fungi [<xref rid="R3" ref-type="bibr">3</xref>-<xref rid="R6" ref-type="bibr">6</xref>]. We show that the genome duplication has expanded gene families, including those involved in signal transduction, and that duplicated genes have specialized, as evidenced by differences in their regulation by light. The transcriptional response to light varies with the developmental stage and is still observed in a photoreceptor mutant of <italic>P. blakesleeanus</italic>. A phototropic mutant of <italic>P. blakesleeanus</italic> with a heterozygous mutation in the photoreceptor gene <italic>madA</italic> demonstrates that photosensor dosage is important for the magnitude of signal transduction. We conclude that the genome duplication provided the means to improve signal transduction for enhanced perception of environmental signals. Our results will help to understand the role of genome dynamics in the evolution of sensory perception in eukaryotes.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9107782</journal-id><journal-id journal-id-type="pubmed-jr-id">8548</journal-id><journal-id journal-id-type="nlm-ta">Curr Biol</journal-id><journal-id journal-id-type="iso-abbrev">Curr. Biol.</journal-id><journal-title-group><journal-title>Current biology : CB</journal-title></journal-title-group><issn pub-type="ppub">0960-9822</issn><issn pub-type="epub">1879-0445</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27238284</article-id><article-id pub-id-type="pmc">5089372</article-id><article-id pub-id-type="doi">10.1016/j.cub.2016.04.038</article-id><article-id pub-id-type="manuscript">NIHMS821540</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Expansion of signal transduction pathways in fungi by extensive genome duplication</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Corrochano</surname><given-names>Luis M.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kuo</surname><given-names>Alan</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Marcet-Houben</surname><given-names>Marina</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Polaino</surname><given-names>Silvia</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Salamov</surname><given-names>Asaf</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Villalobos-Escobedo</surname><given-names>José M.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Grimwood</surname><given-names>Jane</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Álvarez</surname><given-names>M. 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contrib-type="author"><name><surname>Thon</surname><given-names>Michael R.</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Tice</surname><given-names>Hope</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>de Vries</surname><given-names>Ronald P.</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Wiebenga</surname><given-names>Ad</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Yadav</surname><given-names>Jagjit S.</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Braun</surname><given-names>Edward L.</given-names></name><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Baker</surname><given-names>Scott E.</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Garre</surname><given-names>Victoriano</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Schmutz</surname><given-names>Jeremy</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Horwitz</surname><given-names>Benjamin A.</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Torres-Martínez</surname><given-names>Santiago</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Idnurm</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Herrera-Estrella</surname><given-names>Alfredo</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Gabaldón</surname><given-names>Toni</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Grigoriev</surname><given-names>Igor V.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Genetics, University of Seville, Avda. Reina Mercedes s/n, 41012 Seville, Spain</aff><aff id="A2"><label>2</label>U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA</aff><aff id="A3"><label>3</label>Centre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain</aff><aff id="A4"><label>4</label>Universitat Pompeu Fabra (UPF), Doctor Aiguader 88, 08003 Barcelona, Spain</aff><aff id="A5"><label>5</label>School of Biological Sciences, University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO 64110, USA</aff><aff id="A6"><label>6</label>Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, México</aff><aff id="A7"><label>7</label>HudsonAlpha Institute of Biotechnology, 601 Genome Way Northwest, Huntsville, AL 35806, USA</aff><aff id="A8"><label>8</label>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain</aff><aff id="A9"><label>9</label>Instituto Hispano-Luso de Investigaciones Agrarias (CIALE), Universidad de Salamanca, Río Duero 12, 37185 Salamanca, Spain</aff><aff id="A10"><label>10</label>CBS-KNAW Fungal Biodiversity Centre & Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands</aff><aff id="A11"><label>11</label>Universite de Montreal, Pavillon Roger-Gaudry, Biochimie, CP 6128, Succursale Centre-Ville, Montreal QC, H3C 3J7, Canada</aff><aff id="A12"><label>12</label>Department of Biology and Ecology, Faculty of Science, University of Ostrava, Chittussiho 10, 710 00 Ostrava, Czech Republic</aff><aff id="A13"><label>13</label>Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion - Israel Institute of Technology, Haifa 3200003, Israel</aff><aff id="A14"><label>14</label>Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA</aff><aff id="A15"><label>15</label>Centre National de la Recherche Scientifique (CNRS), UMR7257, Université Aix-Marseille, 163 Avenue de Luminy, 13288 Marseille, France</aff><aff id="A16"><label>16</label>Department of Biological Sciences, King Abdulaziz University, P.O Box 80203, Jeddah 21589, Saudi Arabia</aff><aff id="A17"><label>17</label>Genome Analysis Platform, CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Bizkaia, Spain</aff><aff id="A18"><label>18</label>Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain</aff><aff id="A19"><label>19</label>Department of Plant Pathology, Kansas State University, 4024 Throckmorton Plant Sciences Center, Manhattan, KS 66506, USA</aff><aff id="A20"><label>20</label>Department of Biological Sciences, Faculty of Science and Engineering, Ishinomaki Senshu University, Ishinomaki 986-8580, Japan</aff><aff id="A21"><label>21</label>Departamento de Biología Celular y Patología, Facultad de Medicina, Universidad de Salamanca, Avda. Campus Miguel de Unamuno, 37007 Salamanca, Spain</aff><aff id="A22"><label>22</label>Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain</aff><aff id="A23"><label>23</label>Instituto de Agroquímica y Tecnología de Alimentos, Consejo Superior de Investigaciones Científicas (IATA-CSIC), Avda. Catedrático Agustín Escardino 7, 46980 Paterna, Valencia, Spain</aff><aff id="A24"><label>24</label>Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, Mexico</aff><aff id="A25"><label>25</label>Leibniz Institute for Natural Product Research and Infection Biology (Hans Knoell Institute), Beutenbergstr. 11a, 07745 Jena, Germany</aff><aff id="A26"><label>26</label>Biosciences, College of Life & Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4QD, UK</aff><aff id="A27"><label>27</label>Department of Environmental Health, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267-0056, USA</aff><aff id="A28"><label>28</label>Department of Biology, University of Florida, Gainesville, P.O. Box 118525, FL 32611-8525, USA</aff><aff id="A29"><label>29</label>Pacific Northwest National Laboratory, 902 Battelle Blvd., Richland, WA 99352, USA</aff><aff id="A30"><label>30</label>Department of Biology, Technion - Israel Institute of Technology, Haifa 32000, Israel</aff><aff id="A31"><label>31</label>School of BioSciences, University of Melbourne, VIC 3010, Australia</aff><aff id="A32"><label>32</label>Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain</aff><author-notes><corresp id="CR1">Correspondence to: L.M. Corrochano. <email>corrochano@us.es</email>.</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>7</day><month>10</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>26</day><month>5</month><year>2016</year></pub-date><pub-date pub-type="ppub"><day>20</day><month>6</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>20</day><month>6</month><year>2017</year></pub-date><volume>26</volume><issue>12</issue><fpage>1577</fpage><lpage>1584</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.cub.2016.04.038</pmc-comment>
<abstract><title>Summary</title><p id="P1">Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus <italic>Phycomyces blakesleeanus</italic> are single cells that react to environmental cues, including light, but the mechanisms are largely unknown [<xref rid="R1" ref-type="bibr">1</xref>]. The related fungus <italic>Mucor circinelloides</italic> is an opportunistic human pathogen that changes its mode of growth upon receipt of signals from the environment to facilitate pathogenesis [<xref rid="R2" ref-type="bibr">2</xref>]. Understanding how these organisms respond to environmental cues should provide insights into the mechanisms of sensory perception and signal transduction by a single eukaryotic cell, and their role in pathogenesis. We sequenced the genomes of <italic>P. blakesleeanus</italic> and <italic>M. circinelloides</italic>, and show that they have been shaped by an extensive genome duplication or, most likely, a whole genome duplication (WGD), which is rarely observed in fungi [<xref rid="R3" ref-type="bibr">3</xref>-<xref rid="R6" ref-type="bibr">6</xref>]. We show that the genome duplication has expanded gene families, including those involved in signal transduction, and that duplicated genes have specialized, as evidenced by differences in their regulation by light. The transcriptional response to light varies with the developmental stage and is still observed in a photoreceptor mutant of <italic>P. blakesleeanus</italic>. A phototropic mutant of <italic>P. blakesleeanus</italic> with a heterozygous mutation in the photoreceptor gene <italic>madA</italic> demonstrates that photosensor dosage is important for the magnitude of signal transduction. We conclude that the genome duplication provided the means to improve signal transduction for enhanced perception of environmental signals. Our results will help to understand the role of genome dynamics in the evolution of sensory perception in eukaryotes.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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