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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parental occupational paint exposure and risk of childhood leukemia in the offspring: Findings from the Childhood Leukemia International Consortium</title><author><name sortKey="Bailey, Helen D" sort="Bailey, Helen D" uniqKey="Bailey H" first="Helen D" last="Bailey">Helen D. Bailey</name><affiliation><nlm:aff id="A1">International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Fritschi, Lin" sort="Fritschi, Lin" uniqKey="Fritschi L" first="Lin" last="Fritschi">Lin Fritschi</name><affiliation><nlm:aff id="A2">Curtin University, School of Public Health, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="Metayer, Catherine" sort="Metayer, Catherine" uniqKey="Metayer C" first="Catherine" last="Metayer">Catherine Metayer</name><affiliation><nlm:aff id="A3">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff></affiliation></author><author><name sortKey="Infante Rivard, Claire" sort="Infante Rivard, Claire" uniqKey="Infante Rivard C" first="Claire" last="Infante-Rivard">Claire Infante-Rivard</name><affiliation><nlm:aff id="A4">Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University, Canada</nlm:aff></affiliation></author><author><name sortKey="Magnani, Corrado" sort="Magnani, Corrado" uniqKey="Magnani C" first="Corrado" last="Magnani">Corrado Magnani</name><affiliation><nlm:aff id="A5">Dipartimento di Medicina Traslazionale – Università del Piemonte Orientale, AOU Maggiore della Carità e CPO – Piemonte, Novara, Italy</nlm:aff></affiliation></author><author><name sortKey="Petridou, Eleni" sort="Petridou, Eleni" uniqKey="Petridou E" first="Eleni" last="Petridou">Eleni Petridou</name><affiliation><nlm:aff id="A6">Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Medical School, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Spector, Logan G" sort="Spector, Logan G" uniqKey="Spector L" first="Logan G" last="Spector">Logan G. Spector</name><affiliation><nlm:aff id="A8">Division of Epidemiology Clinical Research, Department of Pediatrics and Masonic Cancer Center, University of Minnesota, Minneapolis, United States</nlm:aff></affiliation></author><author><name sortKey="Kaatsch, Peter" sort="Kaatsch, Peter" uniqKey="Kaatsch P" first="Peter" last="Kaatsch">Peter Kaatsch</name><affiliation><nlm:aff id="A9">German Childhood Cancer Registry (GCCR) at the Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz, Germany</nlm:aff></affiliation></author><author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name><affiliation><nlm:aff id="A10">Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Milne, Elizabeth" sort="Milne, Elizabeth" uniqKey="Milne E" first="Elizabeth" last="Milne">Elizabeth Milne</name><affiliation><nlm:aff id="A11">Telethon Institute for Child Health Research, University of Western Australia, Perth Australia</nlm:aff></affiliation></author><author><name sortKey="Dockerty, John D" sort="Dockerty, John D" uniqKey="Dockerty J" first="John D" last="Dockerty">John D. Dockerty</name><affiliation><nlm:aff id="A12">Dean’s Department and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand</nlm:aff></affiliation></author><author><name sortKey="Glass, Deborah C" sort="Glass, Deborah C" uniqKey="Glass D" first="Deborah C" last="Glass">Deborah C. Glass</name><affiliation><nlm:aff id="A13">Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Lightfoot, Tracy" sort="Lightfoot, Tracy" uniqKey="Lightfoot T" first="Tracy" last="Lightfoot">Tracy Lightfoot</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Miligi, Lucia" sort="Miligi, Lucia" uniqKey="Miligi L" first="Lucia" last="Miligi">Lucia Miligi</name><affiliation><nlm:aff id="A14">ISPO-Cancer Prevention and Research Institute, Occupational and Environmental Epidemiology Unit, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Rudant, Jeremie" sort="Rudant, Jeremie" uniqKey="Rudant J" first="Jérémie" last="Rudant">Jérémie Rudant</name><affiliation><nlm:aff id="A10">Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Baka, Margarita" sort="Baka, Margarita" uniqKey="Baka M" first="Margarita" last="Baka">Margarita Baka</name><affiliation><nlm:aff id="A15">Department of Pediatric Hematology-Oncology, “Pan.&Agl. Kyriakou” Children’s Hospital, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Rondelli, Roberto" sort="Rondelli, Roberto" uniqKey="Rondelli R" first="Roberto" last="Rondelli">Roberto Rondelli</name><affiliation><nlm:aff id="A16">Paediatric Haematology -Oncology, Lalla Seràgnoli, Policlinico Sant’Orsola Malpighi Bologna Italy</nlm:aff></affiliation></author><author><name sortKey="Amigou, Alicia" sort="Amigou, Alicia" uniqKey="Amigou A" first="Alicia" last="Amigou">Alicia Amigou</name><affiliation><nlm:aff id="A10">Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Simpson, Jill" sort="Simpson, Jill" uniqKey="Simpson J" first="Jill" last="Simpson">Jill Simpson</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Kang, Alice" sort="Kang, Alice" uniqKey="Kang A" first="Alice" last="Kang">Alice Kang</name><affiliation><nlm:aff id="A3">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff></affiliation></author><author><name sortKey="Moschovi, Maria" sort="Moschovi, Maria" uniqKey="Moschovi M" first="Maria" last="Moschovi">Maria Moschovi</name><affiliation><nlm:aff id="A17">Hematology-Oncology Unit, First Department of Pediatrics, Athens University Medical School, “Aghia Sophia” General Children’s Hospital, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Schuz, Joachim" sort="Schuz, Joachim" uniqKey="Schuz J" first="Joachim" last="Schüz">Joachim Schüz</name><affiliation><nlm:aff id="A1">International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25088805</idno><idno type="pmc">4845093</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845093</idno><idno type="RBID">PMC:4845093</idno><idno type="doi">10.1007/s10552-014-0441-z</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002071</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002071</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Parental occupational paint exposure and risk of childhood leukemia in the offspring: Findings from the Childhood Leukemia International Consortium</title><author><name sortKey="Bailey, Helen D" sort="Bailey, Helen D" uniqKey="Bailey H" first="Helen D" last="Bailey">Helen D. Bailey</name><affiliation><nlm:aff id="A1">International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Fritschi, Lin" sort="Fritschi, Lin" uniqKey="Fritschi L" first="Lin" last="Fritschi">Lin Fritschi</name><affiliation><nlm:aff id="A2">Curtin University, School of Public Health, Perth, Australia</nlm:aff></affiliation></author><author><name sortKey="Metayer, Catherine" sort="Metayer, Catherine" uniqKey="Metayer C" first="Catherine" last="Metayer">Catherine Metayer</name><affiliation><nlm:aff id="A3">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff></affiliation></author><author><name sortKey="Infante Rivard, Claire" sort="Infante Rivard, Claire" uniqKey="Infante Rivard C" first="Claire" last="Infante-Rivard">Claire Infante-Rivard</name><affiliation><nlm:aff id="A4">Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University, Canada</nlm:aff></affiliation></author><author><name sortKey="Magnani, Corrado" sort="Magnani, Corrado" uniqKey="Magnani C" first="Corrado" last="Magnani">Corrado Magnani</name><affiliation><nlm:aff id="A5">Dipartimento di Medicina Traslazionale – Università del Piemonte Orientale, AOU Maggiore della Carità e CPO – Piemonte, Novara, Italy</nlm:aff></affiliation></author><author><name sortKey="Petridou, Eleni" sort="Petridou, Eleni" uniqKey="Petridou E" first="Eleni" last="Petridou">Eleni Petridou</name><affiliation><nlm:aff id="A6">Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Medical School, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Spector, Logan G" sort="Spector, Logan G" uniqKey="Spector L" first="Logan G" last="Spector">Logan G. Spector</name><affiliation><nlm:aff id="A8">Division of Epidemiology Clinical Research, Department of Pediatrics and Masonic Cancer Center, University of Minnesota, Minneapolis, United States</nlm:aff></affiliation></author><author><name sortKey="Kaatsch, Peter" sort="Kaatsch, Peter" uniqKey="Kaatsch P" first="Peter" last="Kaatsch">Peter Kaatsch</name><affiliation><nlm:aff id="A9">German Childhood Cancer Registry (GCCR) at the Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz, Germany</nlm:aff></affiliation></author><author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name><affiliation><nlm:aff id="A10">Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Milne, Elizabeth" sort="Milne, Elizabeth" uniqKey="Milne E" first="Elizabeth" last="Milne">Elizabeth Milne</name><affiliation><nlm:aff id="A11">Telethon Institute for Child Health Research, University of Western Australia, Perth Australia</nlm:aff></affiliation></author><author><name sortKey="Dockerty, John D" sort="Dockerty, John D" uniqKey="Dockerty J" first="John D" last="Dockerty">John D. Dockerty</name><affiliation><nlm:aff id="A12">Dean’s Department and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand</nlm:aff></affiliation></author><author><name sortKey="Glass, Deborah C" sort="Glass, Deborah C" uniqKey="Glass D" first="Deborah C" last="Glass">Deborah C. Glass</name><affiliation><nlm:aff id="A13">Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Lightfoot, Tracy" sort="Lightfoot, Tracy" uniqKey="Lightfoot T" first="Tracy" last="Lightfoot">Tracy Lightfoot</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Miligi, Lucia" sort="Miligi, Lucia" uniqKey="Miligi L" first="Lucia" last="Miligi">Lucia Miligi</name><affiliation><nlm:aff id="A14">ISPO-Cancer Prevention and Research Institute, Occupational and Environmental Epidemiology Unit, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Rudant, Jeremie" sort="Rudant, Jeremie" uniqKey="Rudant J" first="Jérémie" last="Rudant">Jérémie Rudant</name><affiliation><nlm:aff id="A10">Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Baka, Margarita" sort="Baka, Margarita" uniqKey="Baka M" first="Margarita" last="Baka">Margarita Baka</name><affiliation><nlm:aff id="A15">Department of Pediatric Hematology-Oncology, “Pan.&Agl. Kyriakou” Children’s Hospital, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Rondelli, Roberto" sort="Rondelli, Roberto" uniqKey="Rondelli R" first="Roberto" last="Rondelli">Roberto Rondelli</name><affiliation><nlm:aff id="A16">Paediatric Haematology -Oncology, Lalla Seràgnoli, Policlinico Sant’Orsola Malpighi Bologna Italy</nlm:aff></affiliation></author><author><name sortKey="Amigou, Alicia" sort="Amigou, Alicia" uniqKey="Amigou A" first="Alicia" last="Amigou">Alicia Amigou</name><affiliation><nlm:aff id="A10">Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Simpson, Jill" sort="Simpson, Jill" uniqKey="Simpson J" first="Jill" last="Simpson">Jill Simpson</name><affiliation><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Kang, Alice" sort="Kang, Alice" uniqKey="Kang A" first="Alice" last="Kang">Alice Kang</name><affiliation><nlm:aff id="A3">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff></affiliation></author><author><name sortKey="Moschovi, Maria" sort="Moschovi, Maria" uniqKey="Moschovi M" first="Maria" last="Moschovi">Maria Moschovi</name><affiliation><nlm:aff id="A17">Hematology-Oncology Unit, First Department of Pediatrics, Athens University Medical School, “Aghia Sophia” General Children’s Hospital, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Schuz, Joachim" sort="Schuz, Joachim" uniqKey="Schuz J" first="Joachim" last="Schüz">Joachim Schüz</name><affiliation><nlm:aff id="A1">International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer causes & control : CCC</title><idno type="ISSN">0957-5243</idno><idno type="eISSN">1573-7225</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">It has been suggested that parental occupational paint exposure around the time of conception or pregnancy increases the risk of childhood leukemia in the offspring.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We obtained individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium (CLIC). Occupational data were harmonized to a compatible format. Meta-analyses of study-specific odds ratios (ORs) were undertaken, as well as pooled analyses of individual data using unconditional logistic regression.</p></sec><sec id="S3"><title>Results</title><p id="P3">Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic leukaemia (ALL) was 0.93 (95% confidence interval (CI) 0.76, 1.14). Analysis of data from 8,156 ALL case mothers and 14,568 control mothers produced a pooled OR of 0.81 (95% CI 0.39, 1.68) for exposure during pregnancy. For acute myeloid leukaemia (AML), the pooled ORs for paternal and maternal exposure were 0.96 (95% CI 0.65, 1.41) and 1.31 (95% CI 0.38, 4.47) respectively, based on data from 1,231 case and 11,392 control fathers and 1,329 case and 12,141 control mothers. Heterogeneity among the individual studies ranged from low to modest.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Null findings for paternal exposure for both ALL and AML are consistent with previous reports. Despite the large sample size, results for maternal exposure to paints in pregnancy were based on small numbers of exposed. Overall, we found no evidence that parental occupational exposure to paints increases the risk of leukemia in the offspring, but further data on home exposure are needed.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9100846</journal-id><journal-id journal-id-type="pubmed-jr-id">1173</journal-id><journal-id journal-id-type="nlm-ta">Cancer Causes Control</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Causes Control</journal-id><journal-title-group><journal-title>Cancer causes & control : CCC</journal-title></journal-title-group><issn pub-type="ppub">0957-5243</issn><issn pub-type="epub">1573-7225</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25088805</article-id><article-id pub-id-type="pmc">4845093</article-id><article-id pub-id-type="doi">10.1007/s10552-014-0441-z</article-id><article-id pub-id-type="manuscript">NIHMS618772</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Parental occupational paint exposure and risk of childhood leukemia in the offspring: Findings from the Childhood Leukemia International Consortium</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bailey</surname><given-names>Helen D</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Fritschi</surname><given-names>Lin</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Metayer</surname><given-names>Catherine</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Infante-Rivard</surname><given-names>Claire</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Magnani</surname><given-names>Corrado</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Petridou</surname><given-names>Eleni</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Roman</surname><given-names>Eve</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Spector</surname><given-names>Logan G</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Kaatsch</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Clavel</surname><given-names>Jacqueline</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Milne</surname><given-names>Elizabeth</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Dockerty</surname><given-names>John D</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Glass</surname><given-names>Deborah C</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Lightfoot</surname><given-names>Tracy</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Miligi</surname><given-names>Lucia</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Rudant</surname><given-names>Jérémie</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Baka</surname><given-names>Margarita</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Rondelli</surname><given-names>Roberto</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Amigou</surname><given-names>Alicia</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Simpson</surname><given-names>Jill</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>Alice</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Moschovi</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Schüz</surname><given-names>Joachim</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France</aff><aff id="A2"><label>2</label>Curtin University, School of Public Health, Perth, Australia</aff><aff id="A3"><label>3</label>University of California, Berkeley, School of Public Health, Berkeley, United States</aff><aff id="A4"><label>4</label>Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University, Canada</aff><aff id="A5"><label>5</label>Dipartimento di Medicina Traslazionale – Università del Piemonte Orientale, AOU Maggiore della Carità e CPO – Piemonte, Novara, Italy</aff><aff id="A6"><label>6</label>Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Medical School, Athens, Greece</aff><aff id="A7"><label>7</label>Department of Health Sciences, University of York, York, United Kingdom</aff><aff id="A8"><label>8</label>Division of Epidemiology Clinical Research, Department of Pediatrics and Masonic Cancer Center, University of Minnesota, Minneapolis, United States</aff><aff id="A9"><label>9</label>German Childhood Cancer Registry (GCCR) at the Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz, Germany</aff><aff id="A10"><label>10</label>Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud, Paris, France</aff><aff id="A11"><label>11</label>Telethon Institute for Child Health Research, University of Western Australia, Perth Australia</aff><aff id="A12"><label>12</label>Dean’s Department and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand</aff><aff id="A13"><label>13</label>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia</aff><aff id="A14"><label>14</label>ISPO-Cancer Prevention and Research Institute, Occupational and Environmental Epidemiology Unit, Florence, Italy</aff><aff id="A15"><label>15</label>Department of Pediatric Hematology-Oncology, “Pan.&Agl. Kyriakou” Children’s Hospital, Athens, Greece</aff><aff id="A16"><label>16</label>Paediatric Haematology -Oncology, Lalla Seràgnoli, Policlinico Sant’Orsola Malpighi Bologna Italy</aff><aff id="A17"><label>17</label>Hematology-Oncology Unit, First Department of Pediatrics, Athens University Medical School, “Aghia Sophia” General Children’s Hospital, Athens, Greece</aff><author-notes><corresp id="FN1">Address for correspondence: Helen Bailey, Section of Environment and Radiation, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon 69372 Cedex 08, France. Telephone: [+33] (0)4 72 73 8310. Fax: [+33] (0)4 72 73 8320 <email>baileyh@fellows.iarc.fr</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>5</day><month>8</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>05</day><month>8</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>26</day><month>4</month><year>2016</year></pub-date><volume>25</volume><issue>10</issue><fpage>1351</fpage><lpage>1367</lpage><pmc-comment>elocation-id from pubmed: 10.1007/s10552-014-0441-z</pmc-comment>
<abstract><sec id="S1"><title>Purpose</title><p id="P1">It has been suggested that parental occupational paint exposure around the time of conception or pregnancy increases the risk of childhood leukemia in the offspring.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We obtained individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium (CLIC). Occupational data were harmonized to a compatible format. Meta-analyses of study-specific odds ratios (ORs) were undertaken, as well as pooled analyses of individual data using unconditional logistic regression.</p></sec><sec id="S3"><title>Results</title><p id="P3">Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic leukaemia (ALL) was 0.93 (95% confidence interval (CI) 0.76, 1.14). Analysis of data from 8,156 ALL case mothers and 14,568 control mothers produced a pooled OR of 0.81 (95% CI 0.39, 1.68) for exposure during pregnancy. For acute myeloid leukaemia (AML), the pooled ORs for paternal and maternal exposure were 0.96 (95% CI 0.65, 1.41) and 1.31 (95% CI 0.38, 4.47) respectively, based on data from 1,231 case and 11,392 control fathers and 1,329 case and 12,141 control mothers. Heterogeneity among the individual studies ranged from low to modest.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Null findings for paternal exposure for both ALL and AML are consistent with previous reports. Despite the large sample size, results for maternal exposure to paints in pregnancy were based on small numbers of exposed. Overall, we found no evidence that parental occupational exposure to paints increases the risk of leukemia in the offspring, but further data on home exposure are needed.</p></sec></abstract><kwd-group><kwd>paint</kwd><kwd>parental occupation</kwd><kwd>leukemia</kwd><kwd>childhood</kwd><kwd>pooled analysis</kwd><kwd>meta-analysis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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