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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The role of calcium supplementation in healthy musculoskeletal ageing: An Experts consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF)</title><author><name sortKey="Harvey, Nicholas C" sort="Harvey, Nicholas C" uniqKey="Harvey N" first="Nicholas C" last="Harvey">Nicholas C. Harvey</name><affiliation><nlm:aff id="A1">MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Biver, Emmanuel" sort="Biver, Emmanuel" uniqKey="Biver E" first="Emmanuel" last="Biver">Emmanuel Biver</name><affiliation><nlm:aff id="A3">Service of Bone Diseases, University Hospitals Geneva, Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Kaufman, Jean Marc" sort="Kaufman, Jean Marc" uniqKey="Kaufman J" first="Jean-Marc" last="Kaufman">Jean-Marc Kaufman</name><affiliation><nlm:aff id="A4">Dept of Internal Medicine, section Endocrinology, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Bauer, Jurgen" sort="Bauer, Jurgen" uniqKey="Bauer J" first="Jürgen" last="Bauer">Jürgen Bauer</name><affiliation><nlm:aff id="A5">Department of Geriatric Medicine, Klinikum, Carl von Ossietzky University, Ammerländer Heerstrasse 114-118, 26129 Oldenburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Branco, Jaime" sort="Branco, Jaime" uniqKey="Branco J" first="Jaime" last="Branco">Jaime Branco</name><affiliation><nlm:aff id="A6">CEDOC - NOVA Medical School, UNL and Rheumatology Department, CHLO/Hospital Egas Moniz, Lisbon, Portugal</nlm:aff></affiliation></author><author><name sortKey="Brandi, Maria Luisa" sort="Brandi, Maria Luisa" uniqKey="Brandi M" first="Maria Luisa" last="Brandi">Maria Luisa Brandi</name><affiliation><nlm:aff id="A7">Head, Bone and Mineral Metabolic Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Bruyere, Olivier" sort="Bruyere, Olivier" uniqKey="Bruyere O" first="Olivier" last="Bruyère">Olivier Bruyère</name><affiliation><nlm:aff id="A8">Department of Public Health, Epidemiology and Health Economics, University of Liège, Belgium</nlm:aff></affiliation></author><author><name sortKey="Coxam, Veronique" sort="Coxam, Veronique" uniqKey="Coxam V" first="Veronique" last="Coxam">Veronique Coxam</name><affiliation><nlm:aff id="A9">INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermonth-Ferrand, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France</nlm:aff></affiliation></author><author><name sortKey="Cruz Jentoft, Alfonso" sort="Cruz Jentoft, Alfonso" uniqKey="Cruz Jentoft A" first="Alfonso" last="Cruz-Jentoft">Alfonso Cruz-Jentoft</name><affiliation><nlm:aff id="A11">Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (Irycis), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Czerwinski, Edward" sort="Czerwinski, Edward" uniqKey="Czerwinski E" first="Edward" last="Czerwinski">Edward Czerwinski</name><affiliation><nlm:aff id="A12">Department of Bone and Joint Diseases, Jagiellonian University, Faculty of Health Sciences, Krakow Medical Centre, Krakow, Poland</nlm:aff></affiliation></author><author><name sortKey="Dimai, Hans" sort="Dimai, Hans" uniqKey="Dimai H" first="Hans" last="Dimai">Hans Dimai</name><affiliation><nlm:aff id="A13">Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Fardellone, Patrice" sort="Fardellone, Patrice" uniqKey="Fardellone P" first="Patrice" last="Fardellone">Patrice Fardellone</name><affiliation><nlm:aff id="A14">CHU Amiens, Université Picardie - Jules Verne, INSERM U 1088, France</nlm:aff></affiliation></author><author><name sortKey="Landi, Francesco" sort="Landi, Francesco" uniqKey="Landi F" first="Francesco" last="Landi">Francesco Landi</name><affiliation><nlm:aff id="A15">Geriatric Department, Catholic University of Sacred Heart, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Reginster, Jean Yves" sort="Reginster, Jean Yves" uniqKey="Reginster J" first="Jean-Yves" last="Reginster">Jean-Yves Reginster</name><affiliation><nlm:aff id="A16">Director, Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium</nlm:aff></affiliation></author><author><name sortKey="Dawson Hughes, Bess" sort="Dawson Hughes, Bess" uniqKey="Dawson Hughes B" first="Bess" last="Dawson-Hughes">Bess Dawson-Hughes</name><affiliation><nlm:aff id="A17">Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston MA, US</nlm:aff></affiliation></author><author><name sortKey="Kanis, John A" sort="Kanis, John A" uniqKey="Kanis J" first="John A" last="Kanis">John A. Kanis</name><affiliation><nlm:aff id="A18">Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Institute for Health and Ageing, Catholic University of Australia, Melbourne</nlm:aff></affiliation></author><author><name sortKey="Rizzoli, Rene" sort="Rizzoli, Rene" uniqKey="Rizzoli R" first="Rene" last="Rizzoli">Rene Rizzoli</name><affiliation><nlm:aff id="A3">Service of Bone Diseases, University Hospitals Geneva, Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation><nlm:aff id="A1">MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Botnar Research Centre, University of Oxford, Oxford, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27761590</idno><idno type="pmc">5274536</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5274536</idno><idno type="RBID">PMC:5274536</idno><idno type="doi">10.1007/s00198-016-3773-6</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002070</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002070</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The role of calcium supplementation in healthy musculoskeletal ageing: An Experts consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF)</title><author><name sortKey="Harvey, Nicholas C" sort="Harvey, Nicholas C" uniqKey="Harvey N" first="Nicholas C" last="Harvey">Nicholas C. Harvey</name><affiliation><nlm:aff id="A1">MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Biver, Emmanuel" sort="Biver, Emmanuel" uniqKey="Biver E" first="Emmanuel" last="Biver">Emmanuel Biver</name><affiliation><nlm:aff id="A3">Service of Bone Diseases, University Hospitals Geneva, Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Kaufman, Jean Marc" sort="Kaufman, Jean Marc" uniqKey="Kaufman J" first="Jean-Marc" last="Kaufman">Jean-Marc Kaufman</name><affiliation><nlm:aff id="A4">Dept of Internal Medicine, section Endocrinology, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Bauer, Jurgen" sort="Bauer, Jurgen" uniqKey="Bauer J" first="Jürgen" last="Bauer">Jürgen Bauer</name><affiliation><nlm:aff id="A5">Department of Geriatric Medicine, Klinikum, Carl von Ossietzky University, Ammerländer Heerstrasse 114-118, 26129 Oldenburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Branco, Jaime" sort="Branco, Jaime" uniqKey="Branco J" first="Jaime" last="Branco">Jaime Branco</name><affiliation><nlm:aff id="A6">CEDOC - NOVA Medical School, UNL and Rheumatology Department, CHLO/Hospital Egas Moniz, Lisbon, Portugal</nlm:aff></affiliation></author><author><name sortKey="Brandi, Maria Luisa" sort="Brandi, Maria Luisa" uniqKey="Brandi M" first="Maria Luisa" last="Brandi">Maria Luisa Brandi</name><affiliation><nlm:aff id="A7">Head, Bone and Mineral Metabolic Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Bruyere, Olivier" sort="Bruyere, Olivier" uniqKey="Bruyere O" first="Olivier" last="Bruyère">Olivier Bruyère</name><affiliation><nlm:aff id="A8">Department of Public Health, Epidemiology and Health Economics, University of Liège, Belgium</nlm:aff></affiliation></author><author><name sortKey="Coxam, Veronique" sort="Coxam, Veronique" uniqKey="Coxam V" first="Veronique" last="Coxam">Veronique Coxam</name><affiliation><nlm:aff id="A9">INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermonth-Ferrand, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France</nlm:aff></affiliation></author><author><name sortKey="Cruz Jentoft, Alfonso" sort="Cruz Jentoft, Alfonso" uniqKey="Cruz Jentoft A" first="Alfonso" last="Cruz-Jentoft">Alfonso Cruz-Jentoft</name><affiliation><nlm:aff id="A11">Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (Irycis), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Czerwinski, Edward" sort="Czerwinski, Edward" uniqKey="Czerwinski E" first="Edward" last="Czerwinski">Edward Czerwinski</name><affiliation><nlm:aff id="A12">Department of Bone and Joint Diseases, Jagiellonian University, Faculty of Health Sciences, Krakow Medical Centre, Krakow, Poland</nlm:aff></affiliation></author><author><name sortKey="Dimai, Hans" sort="Dimai, Hans" uniqKey="Dimai H" first="Hans" last="Dimai">Hans Dimai</name><affiliation><nlm:aff id="A13">Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Fardellone, Patrice" sort="Fardellone, Patrice" uniqKey="Fardellone P" first="Patrice" last="Fardellone">Patrice Fardellone</name><affiliation><nlm:aff id="A14">CHU Amiens, Université Picardie - Jules Verne, INSERM U 1088, France</nlm:aff></affiliation></author><author><name sortKey="Landi, Francesco" sort="Landi, Francesco" uniqKey="Landi F" first="Francesco" last="Landi">Francesco Landi</name><affiliation><nlm:aff id="A15">Geriatric Department, Catholic University of Sacred Heart, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Reginster, Jean Yves" sort="Reginster, Jean Yves" uniqKey="Reginster J" first="Jean-Yves" last="Reginster">Jean-Yves Reginster</name><affiliation><nlm:aff id="A16">Director, Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium</nlm:aff></affiliation></author><author><name sortKey="Dawson Hughes, Bess" sort="Dawson Hughes, Bess" uniqKey="Dawson Hughes B" first="Bess" last="Dawson-Hughes">Bess Dawson-Hughes</name><affiliation><nlm:aff id="A17">Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston MA, US</nlm:aff></affiliation></author><author><name sortKey="Kanis, John A" sort="Kanis, John A" uniqKey="Kanis J" first="John A" last="Kanis">John A. Kanis</name><affiliation><nlm:aff id="A18">Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Institute for Health and Ageing, Catholic University of Australia, Melbourne</nlm:aff></affiliation></author><author><name sortKey="Rizzoli, Rene" sort="Rizzoli, Rene" uniqKey="Rizzoli R" first="Rene" last="Rizzoli">Rene Rizzoli</name><affiliation><nlm:aff id="A3">Service of Bone Diseases, University Hospitals Geneva, Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation><nlm:aff id="A1">MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Botnar Research Centre, University of Oxford, Oxford, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA</title><idno type="ISSN">0937-941X</idno><idno type="eISSN">1433-2965</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">The place of calcium supplementation, with or without concomitant vitamin D supplementation, has been much debated in terms of both efficacy and safety. There have been numerous trials and meta-analyses of supplementation for fracture reduction, and associations with risk of myocardial infarction have been suggested in recent years. In this report, the product of an expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF), we review the evidence for the value of calcium supplementation, with or without vitamin D supplementation, for healthy musculoskeletal ageing. We conclude that: 1) calcium and vitamin D supplementation leads to a modest reduction in fracture risk, although population-level intervention has not been shown to be an effective public health strategy; 2) supplementation with calcium alone for fracture reduction is not supported by the literature; 3) side effects of calcium supplementation include renal stones and gastrointestinal symptoms; 4) vitamin D supplementation, rather than calcium supplementation, may reduce falls risk; and 5) assertions of increased cardiovascular risk consequent on calcium supplementation are not convincingly supported by current evidence. In conclusion, we recommend, on the basis of the current evidence, that calcium supplementation, with concomitant vitamin D supplementation, is supported for patients at high risk of calcium and vitamin D insufficiency, and in those who are receiving treatment for osteoporosis.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9100105</journal-id><journal-id journal-id-type="pubmed-jr-id">2061</journal-id><journal-id journal-id-type="nlm-ta">Osteoporos Int</journal-id><journal-id journal-id-type="iso-abbrev">Osteoporos Int</journal-id><journal-title-group><journal-title>Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA</journal-title></journal-title-group><issn pub-type="ppub">0937-941X</issn><issn pub-type="epub">1433-2965</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27761590</article-id><article-id pub-id-type="pmc">5274536</article-id><article-id pub-id-type="doi">10.1007/s00198-016-3773-6</article-id><article-id pub-id-type="manuscript">EMS71121</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The role of calcium supplementation in healthy musculoskeletal ageing: An Experts consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Harvey</surname><given-names>Nicholas C</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Biver</surname><given-names>Emmanuel</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Kaufman</surname><given-names>Jean-Marc</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Bauer</surname><given-names>Jürgen</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Branco</surname><given-names>Jaime</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Brandi</surname><given-names>Maria Luisa</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Bruyère</surname><given-names>Olivier</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Coxam</surname><given-names>Veronique</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Cruz-Jentoft</surname><given-names>Alfonso</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Czerwinski</surname><given-names>Edward</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Dimai</surname><given-names>Hans</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Fardellone</surname><given-names>Patrice</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Landi</surname><given-names>Francesco</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Reginster</surname><given-names>Jean-Yves</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Dawson-Hughes</surname><given-names>Bess</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Kanis</surname><given-names>John A</given-names></name><xref ref-type="aff" rid="A18">18</xref><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Rizzoli</surname><given-names>Rene</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="author-notes" rid="FN2">+</xref></contrib><contrib contrib-type="author"><name><surname>Cooper</surname><given-names>Cyrus</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A20">20</xref><xref ref-type="author-notes" rid="FN2">+</xref></contrib></contrib-group><aff id="A1"><label>1</label>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK</aff><aff id="A2"><label>2</label>NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK</aff><aff id="A3"><label>3</label>Service of Bone Diseases, University Hospitals Geneva, Geneva, Switzerland</aff><aff id="A4"><label>4</label>Dept of Internal Medicine, section Endocrinology, Ghent University, Ghent, Belgium</aff><aff id="A5"><label>5</label>Department of Geriatric Medicine, Klinikum, Carl von Ossietzky University, Ammerländer Heerstrasse 114-118, 26129 Oldenburg, Germany</aff><aff id="A6"><label>6</label>CEDOC - NOVA Medical School, UNL and Rheumatology Department, CHLO/Hospital Egas Moniz, Lisbon, Portugal</aff><aff id="A7"><label>7</label>Head, Bone and Mineral Metabolic Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy</aff><aff id="A8"><label>8</label>Department of Public Health, Epidemiology and Health Economics, University of Liège, Belgium</aff><aff id="A9"><label>9</label>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermonth-Ferrand, France</aff><aff id="A10"><label>10</label>Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France</aff><aff id="A11"><label>11</label>Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (Irycis), Madrid, Spain</aff><aff id="A12"><label>12</label>Department of Bone and Joint Diseases, Jagiellonian University, Faculty of Health Sciences, Krakow Medical Centre, Krakow, Poland</aff><aff id="A13"><label>13</label>Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria</aff><aff id="A14"><label>14</label>CHU Amiens, Université Picardie - Jules Verne, INSERM U 1088, France</aff><aff id="A15"><label>15</label>Geriatric Department, Catholic University of Sacred Heart, Milan, Italy</aff><aff id="A16"><label>16</label>Director, Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium</aff><aff id="A17"><label>17</label>Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston MA, US</aff><aff id="A18"><label>18</label>Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK</aff><aff id="A19"><label>19</label>Institute for Health and Ageing, Catholic University of Australia, Melbourne</aff><aff id="A20"><label>20</label>Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Botnar Research Centre, University of Oxford, Oxford, UK</aff><author-notes><corresp id="CR1"><bold>Corresponding author:</bold> Professor Cyrus Cooper, Director and Professor of Rheumatology, MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom. Tel: +44 (0)23 8077 7624; Fax: +44 (0)23 8070 4021; <email>cc@mrc.soton.ac.uk</email></corresp><fn id="FN1"><label>*</label><p id="P1">NCH and EB are joint first author</p></fn><fn id="FN2"><label>+</label><p id="P2">RR and CC are joint senior author</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>17</day><month>1</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>20</day><month>10</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>8</month><year>2017</year></pub-date><volume>28</volume><issue>2</issue><fpage>447</fpage><lpage>462</lpage><pmc-comment>elocation-id from pubmed: 10.1007/s00198-016-3773-6</pmc-comment>
<abstract><p id="P3">The place of calcium supplementation, with or without concomitant vitamin D supplementation, has been much debated in terms of both efficacy and safety. There have been numerous trials and meta-analyses of supplementation for fracture reduction, and associations with risk of myocardial infarction have been suggested in recent years. In this report, the product of an expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF), we review the evidence for the value of calcium supplementation, with or without vitamin D supplementation, for healthy musculoskeletal ageing. We conclude that: 1) calcium and vitamin D supplementation leads to a modest reduction in fracture risk, although population-level intervention has not been shown to be an effective public health strategy; 2) supplementation with calcium alone for fracture reduction is not supported by the literature; 3) side effects of calcium supplementation include renal stones and gastrointestinal symptoms; 4) vitamin D supplementation, rather than calcium supplementation, may reduce falls risk; and 5) assertions of increased cardiovascular risk consequent on calcium supplementation are not convincingly supported by current evidence. In conclusion, we recommend, on the basis of the current evidence, that calcium supplementation, with concomitant vitamin D supplementation, is supported for patients at high risk of calcium and vitamin D insufficiency, and in those who are receiving treatment for osteoporosis.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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