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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Obesity Impairs the Action of the Neuroendocrine Ghrelin System</title><author><name sortKey="Zigman, Jeffrey M" sort="Zigman, Jeffrey M" uniqKey="Zigman J" first="Jeffrey M." last="Zigman">Jeffrey M. Zigman</name><affiliation><nlm:aff id="A1">Departments of Internal Medicine (Divisions of Hypothalamic Research and Endocrinology and Metabolism) and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, 75390-9077, USA</nlm:aff></affiliation></author><author><name sortKey="Bouret, Sebastien G" sort="Bouret, Sebastien G" uniqKey="Bouret S" first="Sebastien G." last="Bouret">Sebastien G. Bouret</name><affiliation><nlm:aff id="A2">The Saban Research Institute, Developmental Neuroscience Program, Children’s Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Inserm, Jean-Pierre Aubert Research Center, U1172, University Lille 2, Lille, 59045, France</nlm:aff></affiliation></author><author><name sortKey="Andrews, Zane B" sort="Andrews, Zane B" uniqKey="Andrews Z" first="Zane B." last="Andrews">Zane B. Andrews</name><affiliation><nlm:aff id="A4">Metabolic Disease and Obesity Theme, Biomedicine Discovery Institute, Department of Physiology, Monash University, Clayton, Victoria 3183, Australia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26542050</idno><idno type="pmc">4814209</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814209</idno><idno type="RBID">PMC:4814209</idno><idno type="doi">10.1016/j.tem.2015.09.010</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002062</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002062</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Obesity Impairs the Action of the Neuroendocrine Ghrelin System</title><author><name sortKey="Zigman, Jeffrey M" sort="Zigman, Jeffrey M" uniqKey="Zigman J" first="Jeffrey M." last="Zigman">Jeffrey M. Zigman</name><affiliation><nlm:aff id="A1">Departments of Internal Medicine (Divisions of Hypothalamic Research and Endocrinology and Metabolism) and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, 75390-9077, USA</nlm:aff></affiliation></author><author><name sortKey="Bouret, Sebastien G" sort="Bouret, Sebastien G" uniqKey="Bouret S" first="Sebastien G." last="Bouret">Sebastien G. Bouret</name><affiliation><nlm:aff id="A2">The Saban Research Institute, Developmental Neuroscience Program, Children’s Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Inserm, Jean-Pierre Aubert Research Center, U1172, University Lille 2, Lille, 59045, France</nlm:aff></affiliation></author><author><name sortKey="Andrews, Zane B" sort="Andrews, Zane B" uniqKey="Andrews Z" first="Zane B." last="Andrews">Zane B. Andrews</name><affiliation><nlm:aff id="A4">Metabolic Disease and Obesity Theme, Biomedicine Discovery Institute, Department of Physiology, Monash University, Clayton, Victoria 3183, Australia</nlm:aff></affiliation></author></analytic><series><title level="j">Trends in endocrinology and metabolism: TEM</title><idno type="ISSN">1043-2760</idno><idno type="eISSN">1879-3061</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Ghrelin is a metabolic hormone that promotes energy conservation by regulating appetite and energy expenditure. Although some studies suggest that antagonizing ghrelin function attenuates body weight gain and glucose intolerance on a high calorie diet, there is little information about the metabolic actions of ghrelin in the obese state. In this review, we discuss the novel concept of obesity-induced central ghrelin resistance in neural circuits regulating behavior, and impaired ghrelin secretion from the stomach. Interestingly, weight loss restores ghrelin secretion and function, and we hypothesize that ghrelin resistance is a mechanism designed to protect a higher body weight set-point established during times of food availability, to maximize energy reserves during a time of food scarcity.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9001516</journal-id><journal-id journal-id-type="pubmed-jr-id">21213</journal-id><journal-id journal-id-type="nlm-ta">Trends Endocrinol Metab</journal-id><journal-id journal-id-type="iso-abbrev">Trends Endocrinol. Metab.</journal-id><journal-title-group><journal-title>Trends in endocrinology and metabolism: TEM</journal-title></journal-title-group><issn pub-type="ppub">1043-2760</issn><issn pub-type="epub">1879-3061</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26542050</article-id><article-id pub-id-type="pmc">4814209</article-id><article-id pub-id-type="doi">10.1016/j.tem.2015.09.010</article-id><article-id pub-id-type="manuscript">NIHMS769029</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Obesity Impairs the Action of the Neuroendocrine Ghrelin System</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zigman</surname><given-names>Jeffrey M.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Bouret</surname><given-names>Sebastien G.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Andrews</surname><given-names>Zane B.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib></contrib-group><aff id="A1"><label>1</label>Departments of Internal Medicine (Divisions of Hypothalamic Research and Endocrinology and Metabolism) and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, 75390-9077, USA</aff><aff id="A2"><label>2</label>The Saban Research Institute, Developmental Neuroscience Program, Children’s Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA</aff><aff id="A3"><label>3</label>Inserm, Jean-Pierre Aubert Research Center, U1172, University Lille 2, Lille, 59045, France</aff><aff id="A4"><label>4</label>Metabolic Disease and Obesity Theme, Biomedicine Discovery Institute, Department of Physiology, Monash University, Clayton, Victoria 3183, Australia</aff><author-notes><corresp id="FN1"><label>*</label>Correspondence: <email>Jeffrey.Zigman@UTSouthwestern.edu</email> (J.M. Zigman)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>16</day><month>3</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>02</day><month>11</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>30</day><month>3</month><year>2016</year></pub-date><volume>27</volume><issue>1</issue><fpage>54</fpage><lpage>63</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.tem.2015.09.010</pmc-comment>
<abstract><p id="P1">Ghrelin is a metabolic hormone that promotes energy conservation by regulating appetite and energy expenditure. Although some studies suggest that antagonizing ghrelin function attenuates body weight gain and glucose intolerance on a high calorie diet, there is little information about the metabolic actions of ghrelin in the obese state. In this review, we discuss the novel concept of obesity-induced central ghrelin resistance in neural circuits regulating behavior, and impaired ghrelin secretion from the stomach. Interestingly, weight loss restores ghrelin secretion and function, and we hypothesize that ghrelin resistance is a mechanism designed to protect a higher body weight set-point established during times of food availability, to maximize energy reserves during a time of food scarcity.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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