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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide association study of body mass index in 23,000 individuals with and without asthma</title><author><name sortKey="Melen, Erik" sort="Melen, Erik" uniqKey="Melen E" first="Erik" last="Melén">Erik Melén</name><affiliation><nlm:aff id="A1">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Granell, Raquel" sort="Granell, Raquel" uniqKey="Granell R" first="Raquel" last="Granell">Raquel Granell</name><affiliation><nlm:aff id="A4">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation><nlm:aff id="A5">Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A7">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A8">National School of Public Health, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Strachan, David" sort="Strachan, David" uniqKey="Strachan D" first="David" last="Strachan">David Strachan</name><affiliation><nlm:aff id="A9">Division of Community Health Sciences, St George’s, University of London, UK</nlm:aff></affiliation></author><author><name sortKey="Gonzalez, Juan R" sort="Gonzalez, Juan R" uniqKey="Gonzalez J" first="Juan R." last="Gonzalez">Juan R. Gonzalez</name><affiliation><nlm:aff id="A5">Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A7">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Wjst, Matthias" sort="Wjst, Matthias" uniqKey="Wjst M" first="Matthias" last="Wjst">Matthias Wjst</name><affiliation><nlm:aff id="A10">Institut for Inhalation Biology, Helmholtz Zentrum München, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Jarvis, Debbie" sort="Jarvis, Debbie" uniqKey="Jarvis D" first="Debbie" last="Jarvis">Debbie Jarvis</name><affiliation><nlm:aff id="A11">Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Ege, Markus" sort="Ege, Markus" uniqKey="Ege M" first="Markus" last="Ege">Markus Ege</name><affiliation><nlm:aff id="A12">University Children’s Hospital Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Braun Fahrl Nder, Charlotte" sort="Braun Fahrl Nder, Charlotte" uniqKey="Braun Fahrl Nder C" first="Charlotte" last="Braun-Fahrl Nder">Charlotte Braun-Fahrl Nder</name><affiliation><nlm:aff id="A13">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Genuneit, Jon" sort="Genuneit, Jon" uniqKey="Genuneit J" first="Jon" last="Genuneit">Jon Genuneit</name><affiliation><nlm:aff id="A15">University of Ulm, Institute of Epidemiology and Medical Biometry, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Horak, Elisabeth" sort="Horak, Elisabeth" uniqKey="Horak E" first="Elisabeth" last="Horak">Elisabeth Horak</name><affiliation><nlm:aff id="A16">Department of Pediatrics and Adolescents, Division of Cardiology and Pulmonology, Innsbruck Medical University, Innsbruck, Austria</nlm:aff></affiliation></author><author><name sortKey="Bouzigon, Emmanuelle" sort="Bouzigon, Emmanuelle" uniqKey="Bouzigon E" first="Emmanuelle" last="Bouzigon">Emmanuelle Bouzigon</name><affiliation><nlm:aff id="A17">Inserm, U946, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Université Paris Diderot, Paris 7, Institut Universitaire d’Hématologie, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France</nlm:aff></affiliation></author><author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name><affiliation><nlm:aff id="A17">Inserm, U946, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Université Paris Diderot, Paris 7, Institut Universitaire d’Hématologie, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France</nlm:aff></affiliation></author><author><name sortKey="Kauffmann, Francine" sort="Kauffmann, Francine" uniqKey="Kauffmann F" first="Francine" last="Kauffmann">Francine Kauffmann</name><affiliation><nlm:aff id="A20">INSERM, CESP Centre for research in Epidemiology and Population Health, U1018, Respiratory and Environmental Epidemiology Team, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Univ Paris Sud 11, UMRS 1018, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Siroux, Valerie" sort="Siroux, Valerie" uniqKey="Siroux V" first="Valérie" last="Siroux">Valérie Siroux</name><affiliation><nlm:aff id="A22">Inserm, U823, Centre de Recherche Albert Bonniot, Grenoble, France</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Univ Joseph Fourier- Grenoble 1, France</nlm:aff></affiliation></author><author><name sortKey="Michel, Sven" sort="Michel, Sven" uniqKey="Michel S" first="Sven" last="Michel">Sven Michel</name><affiliation><nlm:aff id="A24">Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Von Berg, Andrea" sort="Von Berg, Andrea" uniqKey="Von Berg A" first="Andrea" last="Von Berg">Andrea Von Berg</name><affiliation><nlm:aff id="A25">Research Institute for the Prevention of Allergic Diseases, Children's Department, Marien-Hospital, Wesel, Germany</nlm:aff></affiliation></author><author><name sortKey="Heinzmann, Andrea" sort="Heinzmann, Andrea" uniqKey="Heinzmann A" first="Andrea" last="Heinzmann">Andrea Heinzmann</name><affiliation><nlm:aff id="A26">University Children's Hospital, Albert Ludwigs University, Freiburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kabesch, Michael" sort="Kabesch, Michael" uniqKey="Kabesch M" first="Michael" last="Kabesch">Michael Kabesch</name><affiliation><nlm:aff id="A24">Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M." last="Probst-Hensch">Nicole M. Probst-Hensch</name><affiliation><nlm:aff id="A13">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Curjuric, Ivan" sort="Curjuric, Ivan" uniqKey="Curjuric I" first="Ivan" last="Curjuric">Ivan Curjuric</name><affiliation><nlm:aff id="A13">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name><affiliation><nlm:aff id="A13">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Rochat, Thierry" sort="Rochat, Thierry" uniqKey="Rochat T" first="Thierry" last="Rochat">Thierry Rochat</name><affiliation><nlm:aff id="A27">Division of Pulmonary Medicine, University Hospitals of Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Henderson, John" sort="Henderson, John" uniqKey="Henderson J" first="John" last="Henderson">John Henderson</name><affiliation><nlm:aff id="A4">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Sterne, Jonathan A C" sort="Sterne, Jonathan A C" uniqKey="Sterne J" first="Jonathan A. C." last="Sterne">Jonathan A. C. Sterne</name><affiliation><nlm:aff id="A4">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A4">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Hui, Jennie" sort="Hui, Jennie" uniqKey="Hui J" first="Jennie" last="Hui">Jennie Hui</name><affiliation><nlm:aff id="A28">Molecular Genetics, PathWest Laboratory Medicine WA, Nedlands, Western Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Australia</nlm:aff></affiliation></author><author><name sortKey="James, Alan L" sort="James, Alan L" uniqKey="James A" first="Alan L." last="James">Alan L. James</name><affiliation><nlm:aff id="A29">Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Pulmonary Physiology/West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A31">School of Medicine and Pharmacology, University of Western Australia</nlm:aff></affiliation></author><author><name sortKey="Musk, A William" sort="Musk, A William" uniqKey="Musk A" first="A. William" last="Musk">A. William Musk</name><affiliation><nlm:aff id="A29">Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Schools of Population Health and Medicine and Pharmacology, University of Western Australia, Australia</nlm:aff></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J." last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A34">Ontario Institute for Cancer Research, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Samuel Lunenfeld Research Institute, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Becker, Allan" sort="Becker, Allan" uniqKey="Becker A" first="Allan" last="Becker">Allan Becker</name><affiliation><nlm:aff id="A36">Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada</nlm:aff></affiliation></author><author><name sortKey="Kozyrskyj, Anita L" sort="Kozyrskyj, Anita L" uniqKey="Kozyrskyj A" first="Anita L." last="Kozyrskyj">Anita L. Kozyrskyj</name><affiliation><nlm:aff id="A37">Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta and School of Public Health, University of Alberta, Edmonton, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Community Health Sciences, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada</nlm:aff></affiliation></author><author><name sortKey="Chan Young, Moira" sort="Chan Young, Moira" uniqKey="Chan Young M" first="Moira" last="Chan-Young">Moira Chan-Young</name><affiliation><nlm:aff id="A39">Occupational and Environmental Lung Disease Unit, University of British Colombia, Vancouver, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Park, Julie E" sort="Park, Julie E" uniqKey="Park J" first="Julie E." last="Park">Julie E. Park</name><affiliation><nlm:aff id="A40">James Hogg iCAPTURE Center, University of British Columbia, Vancouver, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Leung, Andy" sort="Leung, Andy" uniqKey="Leung A" first="Andy" last="Leung">Andy Leung</name><affiliation><nlm:aff id="A40">James Hogg iCAPTURE Center, University of British Columbia, Vancouver, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Daley, Denise" sort="Daley, Denise" uniqKey="Daley D" first="Denise" last="Daley">Denise Daley</name><affiliation><nlm:aff id="A40">James Hogg iCAPTURE Center, University of British Columbia, Vancouver, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Freidin, Maxim B" sort="Freidin, Maxim B" uniqKey="Freidin M" first="Maxim B." last="Freidin">Maxim B. Freidin</name><affiliation><nlm:aff id="A41">Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia</nlm:aff></affiliation></author><author><name sortKey="Deev, Ivan A" sort="Deev, Ivan A" uniqKey="Deev I" first="Ivan A." last="Deev">Ivan A. Deev</name><affiliation><nlm:aff id="A42">Siberian State Medical University, Tomsk, Russia</nlm:aff></affiliation></author><author><name sortKey="Ogorodova, Ludmila M" sort="Ogorodova, Ludmila M" uniqKey="Ogorodova L" first="Ludmila M." last="Ogorodova">Ludmila M. Ogorodova</name><affiliation><nlm:aff id="A41">Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia</nlm:aff></affiliation></author><author><name sortKey="Puzyrev, Valery P" sort="Puzyrev, Valery P" uniqKey="Puzyrev V" first="Valery P." last="Puzyrev">Valery P. Puzyrev</name><affiliation><nlm:aff id="A41">Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Siberian State Medical University, Tomsk, Russia</nlm:aff></affiliation></author><author><name sortKey="Celed N, Juan C" sort="Celed N, Juan C" uniqKey="Celed N J" first="Juan C." last="Celed N">Juan C. Celed N</name><affiliation><nlm:aff id="A43">Division of Pediatric Pulmonology, Allergy and Immunology, Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA</nlm:aff></affiliation></author><author><name sortKey="Brehm, John M" sort="Brehm, John M" uniqKey="Brehm J" first="John M." last="Brehm">John M. Brehm</name><affiliation><nlm:aff id="A43">Division of Pediatric Pulmonology, Allergy and Immunology, Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA</nlm:aff></affiliation></author><author><name sortKey="Cloutier, Michelle M" sort="Cloutier, Michelle M" uniqKey="Cloutier M" first="Michelle M." last="Cloutier">Michelle M. Cloutier</name><affiliation><nlm:aff id="A44">Department of Pediatrics, University of Connecticut Health Center, Farmington, CT</nlm:aff></affiliation></author><author><name sortKey="Canino, Glorisa" sort="Canino, Glorisa" uniqKey="Canino G" first="Glorisa" last="Canino">Glorisa Canino</name><affiliation><nlm:aff id="A45">Behavioral Sciences Research Institute, University of Puerto Rico, San Juan, PR</nlm:aff></affiliation></author><author><name sortKey="Acosta Perez, Edna" sort="Acosta Perez, Edna" uniqKey="Acosta Perez E" first="Edna" last="Acosta-Pérez">Edna Acosta-Pérez</name><affiliation><nlm:aff id="A45">Behavioral Sciences Research Institute, University of Puerto Rico, San Juan, PR</nlm:aff></affiliation></author><author><name sortKey="Soto Quiros, Manuel" sort="Soto Quiros, Manuel" uniqKey="Soto Quiros M" first="Manuel" last="Soto-Quiros">Manuel Soto-Quiros</name><affiliation><nlm:aff id="A46">Division of Pediatric Pulmonology, Hospital Nacional de Niños, San José, Costa Rica</nlm:aff></affiliation></author><author><name sortKey="Avila, Lydiana" sort="Avila, Lydiana" uniqKey="Avila L" first="Lydiana" last="Avila">Lydiana Avila</name><affiliation><nlm:aff id="A46">Division of Pediatric Pulmonology, Hospital Nacional de Niños, San José, Costa Rica</nlm:aff></affiliation></author><author><name sortKey="Bergstrom, Anna" sort="Bergstrom, Anna" uniqKey="Bergstrom A" first="Anna" last="Bergström">Anna Bergström</name><affiliation><nlm:aff id="A1">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Magnusson, Jessica" sort="Magnusson, Jessica" uniqKey="Magnusson J" first="Jessica" last="Magnusson">Jessica Magnusson</name><affiliation><nlm:aff id="A1">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Soderh Ll, Cilla" sort="Soderh Ll, Cilla" uniqKey="Soderh Ll C" first="Cilla" last="Söderh Ll">Cilla Söderh Ll</name><affiliation><nlm:aff id="A47">Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kull, Inger" sort="Kull, Inger" uniqKey="Kull I" first="Inger" last="Kull">Inger Kull</name><affiliation><nlm:aff id="A1">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Scholtens, Salome" sort="Scholtens, Salome" uniqKey="Scholtens S" first="Salome" last="Scholtens">Salome Scholtens</name><affiliation><nlm:aff id="A48">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Boezen, H Marike" sort="Boezen, H Marike" uniqKey="Boezen H" first="H. Marike" last="Boezen">H. Marike Boezen</name><affiliation><nlm:aff id="A48">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H." last="Koppelman">Gerard H. Koppelman</name><affiliation><nlm:aff id="A49">Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wijga, Alet H" sort="Wijga, Alet H" uniqKey="Wijga A" first="Alet H." last="Wijga">Alet H. Wijga</name><affiliation><nlm:aff id="A50">Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Marenholz, Ingo" sort="Marenholz, Ingo" uniqKey="Marenholz I" first="Ingo" last="Marenholz">Ingo Marenholz</name><affiliation><nlm:aff id="A51">Pediatric Pneumology and Immunology, Charité, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Max-Delbrück-Centrum (MDC) for Molecular Medicine, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Esparza Gordillo, Jorge" sort="Esparza Gordillo, Jorge" uniqKey="Esparza Gordillo J" first="Jorge" last="Esparza-Gordillo">Jorge Esparza-Gordillo</name><affiliation><nlm:aff id="A51">Pediatric Pneumology and Immunology, Charité, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Max-Delbrück-Centrum (MDC) for Molecular Medicine, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Lau, Susanne" sort="Lau, Susanne" uniqKey="Lau S" first="Susanne" last="Lau">Susanne Lau</name><affiliation><nlm:aff id="A51">Pediatric Pneumology and Immunology, Charité, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Lee, Young Ae" sort="Lee, Young Ae" uniqKey="Lee Y" first="Young-Ae" last="Lee">Young-Ae Lee</name><affiliation><nlm:aff id="A51">Pediatric Pneumology and Immunology, Charité, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Max-Delbrück-Centrum (MDC) for Molecular Medicine, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Standl, Marie" sort="Standl, Marie" uniqKey="Standl M" first="Marie" last="Standl">Marie Standl</name><affiliation><nlm:aff id="A53">Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Tiesler, Carla M T" sort="Tiesler, Carla M T" uniqKey="Tiesler C" first="Carla M. T." last="Tiesler">Carla M. T. Tiesler</name><affiliation><nlm:aff id="A53">Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Division of Metabolic Diseases and Nutritional Medicine, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Flexeder, Claudia" sort="Flexeder, Claudia" uniqKey="Flexeder C" first="Claudia" last="Flexeder">Claudia Flexeder</name><affiliation><nlm:aff id="A53">Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation><nlm:aff id="A53">Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Myers, Rachel A" sort="Myers, Rachel A" uniqKey="Myers R" first="Rachel A." last="Myers">Rachel A. Myers</name><affiliation><nlm:aff id="A55">Department of Human Genetics, University of Chicago, Chicago IL, USA</nlm:aff></affiliation></author><author><name sortKey="Ober, Carole" sort="Ober, Carole" uniqKey="Ober C" first="Carole" last="Ober">Carole Ober</name><affiliation><nlm:aff id="A55">Department of Human Genetics, University of Chicago, Chicago IL, USA</nlm:aff></affiliation></author><author><name sortKey="Nicolae, Dan L" sort="Nicolae, Dan L" uniqKey="Nicolae D" first="Dan L." last="Nicolae">Dan L. Nicolae</name><affiliation><nlm:aff id="A56">Departments of Human Genetics, Statistics, and Medicine, University of Chicago, Chicago, IL USA</nlm:aff></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation><nlm:aff id="A57">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Kumar, Ashish" sort="Kumar, Ashish" uniqKey="Kumar A" first="Ashish" last="Kumar">Ashish Kumar</name><affiliation><nlm:aff id="A13">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Moffatt, Miriam F" sort="Moffatt, Miriam F" uniqKey="Moffatt M" first="Miriam F." last="Moffatt">Miriam F. Moffatt</name><affiliation><nlm:aff id="A59">National Heart and Lung Institute (NHLI), Imperial College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Cookson, William O C M" sort="Cookson, William O C M" uniqKey="Cookson W" first="William O. C. M." last="Cookson">William O. C. M. Cookson</name><affiliation><nlm:aff id="A59">National Heart and Lung Institute (NHLI), Imperial College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Lasky Su, Jessica" sort="Lasky Su, Jessica" uniqKey="Lasky Su J" first="Jessica" last="Lasky-Su">Jessica Lasky-Su</name><affiliation><nlm:aff id="A3">Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23517042</idno><idno type="pmc">3608930</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608930</idno><idno type="RBID">PMC:3608930</idno><idno type="doi">10.1111/cea.12054</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002060</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002060</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association study of body mass index in 23,000 individuals with and without asthma</title><author><name sortKey="Melen, Erik" sort="Melen, Erik" uniqKey="Melen E" first="Erik" last="Melén">Erik Melén</name><affiliation><nlm:aff id="A1">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Granell, Raquel" sort="Granell, Raquel" uniqKey="Granell R" first="Raquel" last="Granell">Raquel Granell</name><affiliation><nlm:aff id="A4">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation><nlm:aff id="A5">Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A7">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A8">National School of Public Health, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Strachan, David" sort="Strachan, David" uniqKey="Strachan D" first="David" last="Strachan">David Strachan</name><affiliation><nlm:aff id="A9">Division of Community Health Sciences, St George’s, University of London, UK</nlm:aff></affiliation></author><author><name sortKey="Gonzalez, Juan R" sort="Gonzalez, Juan R" uniqKey="Gonzalez J" first="Juan R." last="Gonzalez">Juan R. Gonzalez</name><affiliation><nlm:aff id="A5">Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A7">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Wjst, Matthias" sort="Wjst, Matthias" uniqKey="Wjst M" first="Matthias" last="Wjst">Matthias Wjst</name><affiliation><nlm:aff id="A10">Institut for Inhalation Biology, Helmholtz Zentrum München, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Jarvis, Debbie" sort="Jarvis, Debbie" uniqKey="Jarvis D" first="Debbie" last="Jarvis">Debbie Jarvis</name><affiliation><nlm:aff id="A11">Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Ege, Markus" sort="Ege, Markus" uniqKey="Ege M" first="Markus" last="Ege">Markus Ege</name><affiliation><nlm:aff id="A12">University Children’s Hospital Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Braun Fahrl Nder, Charlotte" sort="Braun Fahrl Nder, Charlotte" uniqKey="Braun Fahrl Nder C" first="Charlotte" last="Braun-Fahrl Nder">Charlotte Braun-Fahrl Nder</name><affiliation><nlm:aff id="A13">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Genuneit, Jon" sort="Genuneit, Jon" uniqKey="Genuneit J" first="Jon" last="Genuneit">Jon Genuneit</name><affiliation><nlm:aff id="A15">University of Ulm, Institute of Epidemiology and Medical Biometry, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Horak, Elisabeth" sort="Horak, Elisabeth" uniqKey="Horak E" first="Elisabeth" last="Horak">Elisabeth Horak</name><affiliation><nlm:aff id="A16">Department of Pediatrics and Adolescents, Division of Cardiology and Pulmonology, Innsbruck Medical University, Innsbruck, Austria</nlm:aff></affiliation></author><author><name sortKey="Bouzigon, Emmanuelle" sort="Bouzigon, Emmanuelle" uniqKey="Bouzigon E" first="Emmanuelle" last="Bouzigon">Emmanuelle Bouzigon</name><affiliation><nlm:aff id="A17">Inserm, U946, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Université Paris Diderot, Paris 7, Institut Universitaire d’Hématologie, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France</nlm:aff></affiliation></author><author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name><affiliation><nlm:aff id="A17">Inserm, U946, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Université Paris Diderot, Paris 7, Institut Universitaire d’Hématologie, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France</nlm:aff></affiliation></author><author><name sortKey="Kauffmann, Francine" sort="Kauffmann, Francine" uniqKey="Kauffmann F" first="Francine" last="Kauffmann">Francine Kauffmann</name><affiliation><nlm:aff id="A20">INSERM, CESP Centre for research in Epidemiology and Population Health, U1018, Respiratory and Environmental Epidemiology Team, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Univ Paris Sud 11, UMRS 1018, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Siroux, Valerie" sort="Siroux, Valerie" uniqKey="Siroux V" first="Valérie" last="Siroux">Valérie Siroux</name><affiliation><nlm:aff id="A22">Inserm, U823, Centre de Recherche Albert Bonniot, Grenoble, France</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Univ Joseph Fourier- Grenoble 1, France</nlm:aff></affiliation></author><author><name sortKey="Michel, Sven" sort="Michel, Sven" uniqKey="Michel S" first="Sven" last="Michel">Sven Michel</name><affiliation><nlm:aff id="A24">Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Von Berg, Andrea" sort="Von Berg, Andrea" uniqKey="Von Berg A" first="Andrea" last="Von Berg">Andrea Von Berg</name><affiliation><nlm:aff id="A25">Research Institute for the Prevention of Allergic Diseases, Children's Department, Marien-Hospital, Wesel, Germany</nlm:aff></affiliation></author><author><name sortKey="Heinzmann, Andrea" sort="Heinzmann, Andrea" uniqKey="Heinzmann A" first="Andrea" last="Heinzmann">Andrea Heinzmann</name><affiliation><nlm:aff id="A26">University Children's Hospital, Albert Ludwigs University, Freiburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kabesch, Michael" sort="Kabesch, Michael" uniqKey="Kabesch M" first="Michael" last="Kabesch">Michael Kabesch</name><affiliation><nlm:aff id="A24">Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M." last="Probst-Hensch">Nicole M. Probst-Hensch</name><affiliation><nlm:aff id="A13">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Curjuric, Ivan" sort="Curjuric, Ivan" uniqKey="Curjuric I" first="Ivan" last="Curjuric">Ivan Curjuric</name><affiliation><nlm:aff id="A13">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name><affiliation><nlm:aff id="A13">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A14">University of Basel, Basel, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Rochat, Thierry" sort="Rochat, Thierry" uniqKey="Rochat T" first="Thierry" last="Rochat">Thierry Rochat</name><affiliation><nlm:aff id="A27">Division of Pulmonary Medicine, University Hospitals of Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Henderson, John" sort="Henderson, John" uniqKey="Henderson J" first="John" last="Henderson">John Henderson</name><affiliation><nlm:aff id="A4">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Sterne, Jonathan A C" sort="Sterne, Jonathan A C" uniqKey="Sterne J" first="Jonathan A. C." last="Sterne">Jonathan A. C. Sterne</name><affiliation><nlm:aff id="A4">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:aff id="A4">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Hui, Jennie" sort="Hui, Jennie" uniqKey="Hui J" first="Jennie" last="Hui">Jennie Hui</name><affiliation><nlm:aff id="A28">Molecular Genetics, PathWest Laboratory Medicine WA, Nedlands, Western Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Australia</nlm:aff></affiliation></author><author><name sortKey="James, Alan L" sort="James, Alan L" uniqKey="James A" first="Alan L." last="James">Alan L. James</name><affiliation><nlm:aff id="A29">Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Pulmonary Physiology/West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A31">School of Medicine and Pharmacology, University of Western Australia</nlm:aff></affiliation></author><author><name sortKey="Musk, A William" sort="Musk, A William" uniqKey="Musk A" first="A. William" last="Musk">A. William Musk</name><affiliation><nlm:aff id="A29">Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Schools of Population Health and Medicine and Pharmacology, University of Western Australia, Australia</nlm:aff></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J." last="Palmer">Lyle J. Palmer</name><affiliation><nlm:aff id="A34">Ontario Institute for Cancer Research, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Samuel Lunenfeld Research Institute, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Becker, Allan" sort="Becker, Allan" uniqKey="Becker A" first="Allan" last="Becker">Allan Becker</name><affiliation><nlm:aff id="A36">Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada</nlm:aff></affiliation></author><author><name sortKey="Kozyrskyj, Anita L" sort="Kozyrskyj, Anita L" uniqKey="Kozyrskyj A" first="Anita L." last="Kozyrskyj">Anita L. Kozyrskyj</name><affiliation><nlm:aff id="A37">Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta and School of Public Health, University of Alberta, Edmonton, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Community Health Sciences, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada</nlm:aff></affiliation></author><author><name sortKey="Chan Young, Moira" sort="Chan Young, Moira" uniqKey="Chan Young M" first="Moira" last="Chan-Young">Moira Chan-Young</name><affiliation><nlm:aff id="A39">Occupational and Environmental Lung Disease Unit, University of British Colombia, Vancouver, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Park, Julie E" sort="Park, Julie E" uniqKey="Park J" first="Julie E." last="Park">Julie E. Park</name><affiliation><nlm:aff id="A40">James Hogg iCAPTURE Center, University of British Columbia, Vancouver, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Leung, Andy" sort="Leung, Andy" uniqKey="Leung A" first="Andy" last="Leung">Andy Leung</name><affiliation><nlm:aff id="A40">James Hogg iCAPTURE Center, University of British Columbia, Vancouver, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Daley, Denise" sort="Daley, Denise" uniqKey="Daley D" first="Denise" last="Daley">Denise Daley</name><affiliation><nlm:aff id="A40">James Hogg iCAPTURE Center, University of British Columbia, Vancouver, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Freidin, Maxim B" sort="Freidin, Maxim B" uniqKey="Freidin M" first="Maxim B." last="Freidin">Maxim B. Freidin</name><affiliation><nlm:aff id="A41">Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia</nlm:aff></affiliation></author><author><name sortKey="Deev, Ivan A" sort="Deev, Ivan A" uniqKey="Deev I" first="Ivan A." last="Deev">Ivan A. Deev</name><affiliation><nlm:aff id="A42">Siberian State Medical University, Tomsk, Russia</nlm:aff></affiliation></author><author><name sortKey="Ogorodova, Ludmila M" sort="Ogorodova, Ludmila M" uniqKey="Ogorodova L" first="Ludmila M." last="Ogorodova">Ludmila M. Ogorodova</name><affiliation><nlm:aff id="A41">Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia</nlm:aff></affiliation></author><author><name sortKey="Puzyrev, Valery P" sort="Puzyrev, Valery P" uniqKey="Puzyrev V" first="Valery P." last="Puzyrev">Valery P. Puzyrev</name><affiliation><nlm:aff id="A41">Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Siberian State Medical University, Tomsk, Russia</nlm:aff></affiliation></author><author><name sortKey="Celed N, Juan C" sort="Celed N, Juan C" uniqKey="Celed N J" first="Juan C." last="Celed N">Juan C. Celed N</name><affiliation><nlm:aff id="A43">Division of Pediatric Pulmonology, Allergy and Immunology, Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA</nlm:aff></affiliation></author><author><name sortKey="Brehm, John M" sort="Brehm, John M" uniqKey="Brehm J" first="John M." last="Brehm">John M. Brehm</name><affiliation><nlm:aff id="A43">Division of Pediatric Pulmonology, Allergy and Immunology, Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA</nlm:aff></affiliation></author><author><name sortKey="Cloutier, Michelle M" sort="Cloutier, Michelle M" uniqKey="Cloutier M" first="Michelle M." last="Cloutier">Michelle M. Cloutier</name><affiliation><nlm:aff id="A44">Department of Pediatrics, University of Connecticut Health Center, Farmington, CT</nlm:aff></affiliation></author><author><name sortKey="Canino, Glorisa" sort="Canino, Glorisa" uniqKey="Canino G" first="Glorisa" last="Canino">Glorisa Canino</name><affiliation><nlm:aff id="A45">Behavioral Sciences Research Institute, University of Puerto Rico, San Juan, PR</nlm:aff></affiliation></author><author><name sortKey="Acosta Perez, Edna" sort="Acosta Perez, Edna" uniqKey="Acosta Perez E" first="Edna" last="Acosta-Pérez">Edna Acosta-Pérez</name><affiliation><nlm:aff id="A45">Behavioral Sciences Research Institute, University of Puerto Rico, San Juan, PR</nlm:aff></affiliation></author><author><name sortKey="Soto Quiros, Manuel" sort="Soto Quiros, Manuel" uniqKey="Soto Quiros M" first="Manuel" last="Soto-Quiros">Manuel Soto-Quiros</name><affiliation><nlm:aff id="A46">Division of Pediatric Pulmonology, Hospital Nacional de Niños, San José, Costa Rica</nlm:aff></affiliation></author><author><name sortKey="Avila, Lydiana" sort="Avila, Lydiana" uniqKey="Avila L" first="Lydiana" last="Avila">Lydiana Avila</name><affiliation><nlm:aff id="A46">Division of Pediatric Pulmonology, Hospital Nacional de Niños, San José, Costa Rica</nlm:aff></affiliation></author><author><name sortKey="Bergstrom, Anna" sort="Bergstrom, Anna" uniqKey="Bergstrom A" first="Anna" last="Bergström">Anna Bergström</name><affiliation><nlm:aff id="A1">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Magnusson, Jessica" sort="Magnusson, Jessica" uniqKey="Magnusson J" first="Jessica" last="Magnusson">Jessica Magnusson</name><affiliation><nlm:aff id="A1">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Soderh Ll, Cilla" sort="Soderh Ll, Cilla" uniqKey="Soderh Ll C" first="Cilla" last="Söderh Ll">Cilla Söderh Ll</name><affiliation><nlm:aff id="A47">Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kull, Inger" sort="Kull, Inger" uniqKey="Kull I" first="Inger" last="Kull">Inger Kull</name><affiliation><nlm:aff id="A1">Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Scholtens, Salome" sort="Scholtens, Salome" uniqKey="Scholtens S" first="Salome" last="Scholtens">Salome Scholtens</name><affiliation><nlm:aff id="A48">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Boezen, H Marike" sort="Boezen, H Marike" uniqKey="Boezen H" first="H. Marike" last="Boezen">H. Marike Boezen</name><affiliation><nlm:aff id="A48">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H." last="Koppelman">Gerard H. Koppelman</name><affiliation><nlm:aff id="A49">Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wijga, Alet H" sort="Wijga, Alet H" uniqKey="Wijga A" first="Alet H." last="Wijga">Alet H. Wijga</name><affiliation><nlm:aff id="A50">Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Marenholz, Ingo" sort="Marenholz, Ingo" uniqKey="Marenholz I" first="Ingo" last="Marenholz">Ingo Marenholz</name><affiliation><nlm:aff id="A51">Pediatric Pneumology and Immunology, Charité, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Max-Delbrück-Centrum (MDC) for Molecular Medicine, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Esparza Gordillo, Jorge" sort="Esparza Gordillo, Jorge" uniqKey="Esparza Gordillo J" first="Jorge" last="Esparza-Gordillo">Jorge Esparza-Gordillo</name><affiliation><nlm:aff id="A51">Pediatric Pneumology and Immunology, Charité, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Max-Delbrück-Centrum (MDC) for Molecular Medicine, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Lau, Susanne" sort="Lau, Susanne" uniqKey="Lau S" first="Susanne" last="Lau">Susanne Lau</name><affiliation><nlm:aff id="A51">Pediatric Pneumology and Immunology, Charité, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Lee, Young Ae" sort="Lee, Young Ae" uniqKey="Lee Y" first="Young-Ae" last="Lee">Young-Ae Lee</name><affiliation><nlm:aff id="A51">Pediatric Pneumology and Immunology, Charité, Berlin, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Max-Delbrück-Centrum (MDC) for Molecular Medicine, Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Standl, Marie" sort="Standl, Marie" uniqKey="Standl M" first="Marie" last="Standl">Marie Standl</name><affiliation><nlm:aff id="A53">Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Tiesler, Carla M T" sort="Tiesler, Carla M T" uniqKey="Tiesler C" first="Carla M. T." last="Tiesler">Carla M. T. Tiesler</name><affiliation><nlm:aff id="A53">Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Division of Metabolic Diseases and Nutritional Medicine, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Flexeder, Claudia" sort="Flexeder, Claudia" uniqKey="Flexeder C" first="Claudia" last="Flexeder">Claudia Flexeder</name><affiliation><nlm:aff id="A53">Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name><affiliation><nlm:aff id="A53">Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Myers, Rachel A" sort="Myers, Rachel A" uniqKey="Myers R" first="Rachel A." last="Myers">Rachel A. Myers</name><affiliation><nlm:aff id="A55">Department of Human Genetics, University of Chicago, Chicago IL, USA</nlm:aff></affiliation></author><author><name sortKey="Ober, Carole" sort="Ober, Carole" uniqKey="Ober C" first="Carole" last="Ober">Carole Ober</name><affiliation><nlm:aff id="A55">Department of Human Genetics, University of Chicago, Chicago IL, USA</nlm:aff></affiliation></author><author><name sortKey="Nicolae, Dan L" sort="Nicolae, Dan L" uniqKey="Nicolae D" first="Dan L." last="Nicolae">Dan L. Nicolae</name><affiliation><nlm:aff id="A56">Departments of Human Genetics, Statistics, and Medicine, University of Chicago, Chicago, IL USA</nlm:aff></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation><nlm:aff id="A57">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Kumar, Ashish" sort="Kumar, Ashish" uniqKey="Kumar A" first="Ashish" last="Kumar">Ashish Kumar</name><affiliation><nlm:aff id="A13">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Moffatt, Miriam F" sort="Moffatt, Miriam F" uniqKey="Moffatt M" first="Miriam F." last="Moffatt">Miriam F. Moffatt</name><affiliation><nlm:aff id="A59">National Heart and Lung Institute (NHLI), Imperial College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Cookson, William O C M" sort="Cookson, William O C M" uniqKey="Cookson W" first="William O. C. M." last="Cookson">William O. C. M. Cookson</name><affiliation><nlm:aff id="A59">National Heart and Lung Institute (NHLI), Imperial College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Lasky Su, Jessica" sort="Lasky Su, Jessica" uniqKey="Lasky Su J" first="Jessica" last="Lasky-Su">Jessica Lasky-Su</name><affiliation><nlm:aff id="A3">Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</nlm:aff></affiliation></author></analytic><series><title level="j">Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology</title><idno type="ISSN">0954-7894</idno><idno type="eISSN">1365-2222</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Both asthma and obesity are complex disorders that are influenced by environmental and genetic factors. Shared genetic factors between asthma and obesity have been proposed to partly explain epidemiological findings of co-morbidity between these conditions.</p></sec><sec id="S2"><title>Objective</title><p id="P2">To identify genetic variants that are associated with body mass index (BMI) in asthmatic children and adults, and to evaluate if there are differences between the genetics of BMI in asthmatics and healthy individuals.</p></sec><sec id="S3"><title>Methods</title><p id="P3">In total, 19 studies contributed with genome-wide analysis study (GWAS) data from more than 23,000 individuals with predominantly European descent, of whom 8,165 are asthmatics.</p></sec><sec id="S4"><title>Results</title><p id="P4">We report associations between several <italic>DENND1B</italic> variants (p=2.2×10<sup>−7</sup> for rs4915551) on chromosome 1q31 and BMI from a meta-analysis of GWAS data using 2,691 asthmatic children (screening data). The top <italic>DENND1B</italic> SNPs were next evaluated in seven independent replication data sets comprising 2,014 asthmatics, and rs4915551 was nominally replicated (p<0.05) in two of the seven studies and of borderline significance in one (p=0.059). However, strong evidence of effect heterogeneity was observed and overall, the association between rs4915551 and BMI was not significant in the total replication data set, p=0.71. Using a random effects model, BMI was overall estimated to increase by 0.30 kg/m<sup>2</sup> (p=0.01 for combined screening and replication data sets, N=4,705) per additional G allele of this <italic>DENND1B</italic> SNP. <italic>FTO</italic> was confirmed as an important gene for adult and childhood BMI regardless of asthma status.</p></sec><sec id="S5"><title>Conclusions and Clinical Relevance</title><p id="P5"><italic>DENND1B</italic> was recently identified as an asthma susceptibility gene in a GWAS on children, and here we find evidence that <italic>DENND1B</italic> variants may also be associated with BMI in asthmatic children. However, the association was overall not replicated in the independent data sets and the heterogeneous effect of <italic>DENND1B</italic> points to complex associations with the studied diseases that deserve further study.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8906443</journal-id><journal-id journal-id-type="pubmed-jr-id">2701</journal-id><journal-id journal-id-type="nlm-ta">Clin Exp Allergy</journal-id><journal-id journal-id-type="iso-abbrev">Clin. Exp. Allergy</journal-id><journal-title-group><journal-title>Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology</journal-title></journal-title-group><issn pub-type="ppub">0954-7894</issn><issn pub-type="epub">1365-2222</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23517042</article-id><article-id pub-id-type="pmc">3608930</article-id><article-id pub-id-type="doi">10.1111/cea.12054</article-id><article-id pub-id-type="manuscript">NIHMS420161</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Genome-wide association study of body mass index in 23,000 individuals with and without asthma</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Melén</surname><given-names>Erik</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref 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T.</given-names></name><xref ref-type="aff" rid="A53">53</xref><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Flexeder</surname><given-names>Claudia</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Heinrich</surname><given-names>Joachim</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Myers</surname><given-names>Rachel A.</given-names></name><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><name><surname>Ober</surname><given-names>Carole</given-names></name><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><name><surname>Nicolae</surname><given-names>Dan L.</given-names></name><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Farrall</surname><given-names>Martin</given-names></name><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Kumar</surname><given-names>Ashish</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A57">57</xref><xref ref-type="aff" rid="A58">58</xref></contrib><contrib contrib-type="author"><name><surname>Moffatt</surname><given-names>Miriam F.</given-names></name><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Cookson</surname><given-names>William O.C.M.</given-names></name><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Lasky-Su</surname><given-names>Jessica</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A2"><label>2</label>Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A3"><label>3</label>Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</aff><aff id="A4"><label>4</label>School of Social and Community Medicine, University of Bristol, UK</aff><aff id="A5"><label>5</label>Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</aff><aff id="A6"><label>6</label>Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona, Spain</aff><aff id="A7"><label>7</label>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</aff><aff id="A8"><label>8</label>National School of Public Health, Athens, Greece</aff><aff id="A9"><label>9</label>Division of Community Health Sciences, St George’s, University of London, UK</aff><aff id="A10"><label>10</label>Institut for Inhalation Biology, Helmholtz Zentrum München, Neuherberg, Germany</aff><aff id="A11"><label>11</label>Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College, London, UK</aff><aff id="A12"><label>12</label>University Children’s Hospital Munich, Munich, Germany</aff><aff id="A13"><label>13</label>Swiss Tropical and Public Health Institute, Basel, Switzerland</aff><aff id="A14"><label>14</label>University of Basel, Basel, Switzerland</aff><aff id="A15"><label>15</label>University of Ulm, Institute of Epidemiology and Medical Biometry, Ulm, Germany</aff><aff id="A16"><label>16</label>Department of Pediatrics and Adolescents, Division of Cardiology and Pulmonology, Innsbruck Medical University, Innsbruck, Austria</aff><aff id="A17"><label>17</label>Inserm, U946, Paris, France</aff><aff id="A18"><label>18</label>Université Paris Diderot, Paris 7, Institut Universitaire d’Hématologie, Paris, France</aff><aff id="A19"><label>19</label>Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France</aff><aff id="A20"><label>20</label>INSERM, CESP Centre for research in Epidemiology and Population Health, U1018, Respiratory and Environmental Epidemiology Team, Villejuif, France</aff><aff id="A21"><label>21</label>Univ Paris Sud 11, UMRS 1018, Villejuif, France</aff><aff id="A22"><label>22</label>Inserm, U823, Centre de Recherche Albert Bonniot, Grenoble, France</aff><aff id="A23"><label>23</label>Univ Joseph Fourier- Grenoble 1, France</aff><aff id="A24"><label>24</label>Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany</aff><aff id="A25"><label>25</label>Research Institute for the Prevention of Allergic Diseases, Children's Department, Marien-Hospital, Wesel, Germany</aff><aff id="A26"><label>26</label>University Children's Hospital, Albert Ludwigs University, Freiburg, Germany</aff><aff id="A27"><label>27</label>Division of Pulmonary Medicine, University Hospitals of Geneva, Switzerland</aff><aff id="A28"><label>28</label>Molecular Genetics, PathWest Laboratory Medicine WA, Nedlands, Western Australia</aff><aff id="A29"><label>29</label>Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Australia</aff><aff id="A30"><label>30</label>Department of Pulmonary Physiology/West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Australia</aff><aff id="A31"><label>31</label>School of Medicine and Pharmacology, University of Western Australia</aff><aff id="A32"><label>32</label>Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Australia</aff><aff id="A33"><label>33</label>Schools of Population Health and Medicine and Pharmacology, University of Western Australia, Australia</aff><aff id="A34"><label>34</label>Ontario Institute for Cancer Research, Toronto, Canada</aff><aff id="A35"><label>35</label>Samuel Lunenfeld Research Institute, Toronto, Canada</aff><aff id="A36"><label>36</label>Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada</aff><aff id="A37"><label>37</label>Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta and School of Public Health, University of Alberta, Edmonton, Canada</aff><aff id="A38"><label>38</label>Department of Community Health Sciences, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada</aff><aff id="A39"><label>39</label>Occupational and Environmental Lung Disease Unit, University of British Colombia, Vancouver, BC, Canada</aff><aff id="A40"><label>40</label>James Hogg iCAPTURE Center, University of British Columbia, Vancouver, BC, Canada</aff><aff id="A41"><label>41</label>Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia</aff><aff id="A42"><label>42</label>Siberian State Medical University, Tomsk, Russia</aff><aff id="A43"><label>43</label>Division of Pediatric Pulmonology, Allergy and Immunology, Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA</aff><aff id="A44"><label>44</label>Department of Pediatrics, University of Connecticut Health Center, Farmington, CT</aff><aff id="A45"><label>45</label>Behavioral Sciences Research Institute, University of Puerto Rico, San Juan, PR</aff><aff id="A46"><label>46</label>Division of Pediatric Pulmonology, Hospital Nacional de Niños, San José, Costa Rica</aff><aff id="A47"><label>47</label>Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A48"><label>48</label>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</aff><aff id="A49"><label>49</label>Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A50"><label>50</label>Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands</aff><aff id="A51"><label>51</label>Pediatric Pneumology and Immunology, Charité, Berlin, Germany</aff><aff id="A52"><label>52</label>Max-Delbrück-Centrum (MDC) for Molecular Medicine, Berlin, Germany</aff><aff id="A53"><label>53</label>Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany</aff><aff id="A54"><label>54</label>Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Division of Metabolic Diseases and Nutritional Medicine, Munich, Germany</aff><aff id="A55"><label>55</label>Department of Human Genetics, University of Chicago, Chicago IL, USA</aff><aff id="A56"><label>56</label>Departments of Human Genetics, Statistics, and Medicine, University of Chicago, Chicago, IL USA</aff><aff id="A57"><label>57</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</aff><aff id="A58"><label>58</label>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom</aff><aff id="A59"><label>59</label>National Heart and Lung Institute (NHLI), Imperial College, London, UK</aff><author-notes><corresp id="cor1">Address correspondence and request for reprints to: Erik Melén, MD, PhD, Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden, Phone: +468 524 87508; Fax: +468 304 571; <email>erik.melen@ki.se</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>24</day><month>11</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>4</month><year>2014</year></pub-date><volume>43</volume><issue>4</issue><fpage>463</fpage><lpage>474</lpage><pmc-comment>elocation-id from pubmed: 10.1111/cea.12054</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">Both asthma and obesity are complex disorders that are influenced by environmental and genetic factors. Shared genetic factors between asthma and obesity have been proposed to partly explain epidemiological findings of co-morbidity between these conditions.</p></sec><sec id="S2"><title>Objective</title><p id="P2">To identify genetic variants that are associated with body mass index (BMI) in asthmatic children and adults, and to evaluate if there are differences between the genetics of BMI in asthmatics and healthy individuals.</p></sec><sec id="S3"><title>Methods</title><p id="P3">In total, 19 studies contributed with genome-wide analysis study (GWAS) data from more than 23,000 individuals with predominantly European descent, of whom 8,165 are asthmatics.</p></sec><sec id="S4"><title>Results</title><p id="P4">We report associations between several <italic>DENND1B</italic> variants (p=2.2×10<sup>−7</sup> for rs4915551) on chromosome 1q31 and BMI from a meta-analysis of GWAS data using 2,691 asthmatic children (screening data). The top <italic>DENND1B</italic> SNPs were next evaluated in seven independent replication data sets comprising 2,014 asthmatics, and rs4915551 was nominally replicated (p<0.05) in two of the seven studies and of borderline significance in one (p=0.059). However, strong evidence of effect heterogeneity was observed and overall, the association between rs4915551 and BMI was not significant in the total replication data set, p=0.71. Using a random effects model, BMI was overall estimated to increase by 0.30 kg/m<sup>2</sup> (p=0.01 for combined screening and replication data sets, N=4,705) per additional G allele of this <italic>DENND1B</italic> SNP. <italic>FTO</italic> was confirmed as an important gene for adult and childhood BMI regardless of asthma status.</p></sec><sec id="S5"><title>Conclusions and Clinical Relevance</title><p id="P5"><italic>DENND1B</italic> was recently identified as an asthma susceptibility gene in a GWAS on children, and here we find evidence that <italic>DENND1B</italic> variants may also be associated with BMI in asthmatic children. However, the association was overall not replicated in the independent data sets and the heterogeneous effect of <italic>DENND1B</italic> points to complex associations with the studied diseases that deserve further study.</p></sec></abstract><kwd-group><kwd>Association</kwd><kwd>Asthma</kwd><kwd>BMI</kwd><kwd>Genetics</kwd><kwd>Genome-wide</kwd><kwd>Obesity</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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