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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Biomarkers of Oxidative Stress Study V: Ozone exposure of rats and its effect on lipids, proteins and DNA in plasma and urine</title><author><name sortKey="Kadiiska, Maria B" sort="Kadiiska, Maria B" uniqKey="Kadiiska M" first="Maria B." last="Kadiiska">Maria B. Kadiiska</name><affiliation><nlm:aff id="A1">National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Basu, Samar" sort="Basu, Samar" uniqKey="Basu S" first="Samar" last="Basu">Samar Basu</name><affiliation><nlm:aff id="A2">Faculty of Medicine, Uppsala University, Uppsala, Sweden and Biochemistry, Molecular Biology and Nutrition Department, University of Auvergne, Clermont-Ferrand, France</nlm:aff></affiliation></author><author><name sortKey="Brot, Nathan" sort="Brot, Nathan" uniqKey="Brot N" first="Nathan" last="Brot">Nathan Brot</name><affiliation><nlm:aff id="A3">Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Cooper, Christopher" sort="Cooper, Christopher" uniqKey="Cooper C" first="Christopher" last="Cooper">Christopher Cooper</name><affiliation><nlm:aff id="A4">School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK</nlm:aff></affiliation></author><author><name sortKey="Csallany, A Saari" sort="Csallany, A Saari" uniqKey="Csallany A" first="A. Saari" last="Csallany">A. Saari Csallany</name><affiliation><nlm:aff id="A5">Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Davies, Michael J" sort="Davies, Michael J" uniqKey="Davies M" first="Michael J." last="Davies">Michael J. Davies</name><affiliation><nlm:aff id="A6">The Heart Research Institute, University of Sydney, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="George, Magdalene M" sort="George, Magdalene M" uniqKey="George M" first="Magdalene M." last="George">Magdalene M. George</name><affiliation><nlm:aff id="A7">Rush University Medical Center, Chicago, IL USA</nlm:aff></affiliation></author><author><name sortKey="Murray, Dennis M" sort="Murray, Dennis M" uniqKey="Murray D" first="Dennis M." last="Murray">Dennis M. Murray</name><affiliation><nlm:aff id="A8">Northwest Life Science Specialties, LLC., Vancouver, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Roberts, L Jackson" sort="Roberts, L Jackson" uniqKey="Roberts L" first="L. Jackson" last="Roberts">L. Jackson Roberts</name><affiliation><nlm:aff id="A9">Dept. Pharmacology and Medicine, Vanderbilt University, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Shigenaga, Mark K" sort="Shigenaga, Mark K" uniqKey="Shigenaga M" first="Mark K." last="Shigenaga">Mark K. Shigenaga</name><affiliation><nlm:aff id="A10">Children's Hospital Oakland Research Institute, Oakland, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Sohal, Rajindar S" sort="Sohal, Rajindar S" uniqKey="Sohal R" first="Rajindar S." last="Sohal">Rajindar S. Sohal</name><affiliation><nlm:aff id="A11">University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Stocker, Roland" sort="Stocker, Roland" uniqKey="Stocker R" first="Roland" last="Stocker">Roland Stocker</name><affiliation><nlm:aff id="A12">Victor Chang Cardiac Research Institute, Darlinghurst, Australia</nlm:aff></affiliation></author><author><name sortKey="Van Thiel, David H" sort="Van Thiel, David H" uniqKey="Van Thiel D" first="David H." last="Van Thiel">David H. Van Thiel</name><affiliation><nlm:aff id="A7">Rush University Medical Center, Chicago, IL USA</nlm:aff></affiliation></author><author><name sortKey="Wiswedel, Ingrid" sort="Wiswedel, Ingrid" uniqKey="Wiswedel I" first="Ingrid" last="Wiswedel">Ingrid Wiswedel</name><affiliation><nlm:aff id="A13">Department of Pathobiochemistry, Medical Faculty, Otto-von-Guericke-University, Magdeburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hatch, Gary E" sort="Hatch, Gary E" uniqKey="Hatch G" first="Gary E." last="Hatch">Gary E. Hatch</name><affiliation><nlm:aff id="A14">United States Environmental Protection Agency, Research Triangle Park, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Mason, Ronald P" sort="Mason, Ronald P" uniqKey="Mason R" first="Ronald P." last="Mason">Ronald P. Mason</name><affiliation><nlm:aff id="A1">National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23608465</idno><idno type="pmc">3968235</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968235</idno><idno type="RBID">PMC:3968235</idno><idno type="doi">10.1016/j.freeradbiomed.2013.04.023</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002051</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002051</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Biomarkers of Oxidative Stress Study V: Ozone exposure of rats and its effect on lipids, proteins and DNA in plasma and urine</title><author><name sortKey="Kadiiska, Maria B" sort="Kadiiska, Maria B" uniqKey="Kadiiska M" first="Maria B." last="Kadiiska">Maria B. Kadiiska</name><affiliation><nlm:aff id="A1">National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Basu, Samar" sort="Basu, Samar" uniqKey="Basu S" first="Samar" last="Basu">Samar Basu</name><affiliation><nlm:aff id="A2">Faculty of Medicine, Uppsala University, Uppsala, Sweden and Biochemistry, Molecular Biology and Nutrition Department, University of Auvergne, Clermont-Ferrand, France</nlm:aff></affiliation></author><author><name sortKey="Brot, Nathan" sort="Brot, Nathan" uniqKey="Brot N" first="Nathan" last="Brot">Nathan Brot</name><affiliation><nlm:aff id="A3">Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Cooper, Christopher" sort="Cooper, Christopher" uniqKey="Cooper C" first="Christopher" last="Cooper">Christopher Cooper</name><affiliation><nlm:aff id="A4">School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK</nlm:aff></affiliation></author><author><name sortKey="Csallany, A Saari" sort="Csallany, A Saari" uniqKey="Csallany A" first="A. Saari" last="Csallany">A. Saari Csallany</name><affiliation><nlm:aff id="A5">Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Davies, Michael J" sort="Davies, Michael J" uniqKey="Davies M" first="Michael J." last="Davies">Michael J. Davies</name><affiliation><nlm:aff id="A6">The Heart Research Institute, University of Sydney, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="George, Magdalene M" sort="George, Magdalene M" uniqKey="George M" first="Magdalene M." last="George">Magdalene M. George</name><affiliation><nlm:aff id="A7">Rush University Medical Center, Chicago, IL USA</nlm:aff></affiliation></author><author><name sortKey="Murray, Dennis M" sort="Murray, Dennis M" uniqKey="Murray D" first="Dennis M." last="Murray">Dennis M. Murray</name><affiliation><nlm:aff id="A8">Northwest Life Science Specialties, LLC., Vancouver, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Roberts, L Jackson" sort="Roberts, L Jackson" uniqKey="Roberts L" first="L. Jackson" last="Roberts">L. Jackson Roberts</name><affiliation><nlm:aff id="A9">Dept. Pharmacology and Medicine, Vanderbilt University, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Shigenaga, Mark K" sort="Shigenaga, Mark K" uniqKey="Shigenaga M" first="Mark K." last="Shigenaga">Mark K. Shigenaga</name><affiliation><nlm:aff id="A10">Children's Hospital Oakland Research Institute, Oakland, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Sohal, Rajindar S" sort="Sohal, Rajindar S" uniqKey="Sohal R" first="Rajindar S." last="Sohal">Rajindar S. Sohal</name><affiliation><nlm:aff id="A11">University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Stocker, Roland" sort="Stocker, Roland" uniqKey="Stocker R" first="Roland" last="Stocker">Roland Stocker</name><affiliation><nlm:aff id="A12">Victor Chang Cardiac Research Institute, Darlinghurst, Australia</nlm:aff></affiliation></author><author><name sortKey="Van Thiel, David H" sort="Van Thiel, David H" uniqKey="Van Thiel D" first="David H." last="Van Thiel">David H. Van Thiel</name><affiliation><nlm:aff id="A7">Rush University Medical Center, Chicago, IL USA</nlm:aff></affiliation></author><author><name sortKey="Wiswedel, Ingrid" sort="Wiswedel, Ingrid" uniqKey="Wiswedel I" first="Ingrid" last="Wiswedel">Ingrid Wiswedel</name><affiliation><nlm:aff id="A13">Department of Pathobiochemistry, Medical Faculty, Otto-von-Guericke-University, Magdeburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hatch, Gary E" sort="Hatch, Gary E" uniqKey="Hatch G" first="Gary E." last="Hatch">Gary E. Hatch</name><affiliation><nlm:aff id="A14">United States Environmental Protection Agency, Research Triangle Park, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Mason, Ronald P" sort="Mason, Ronald P" uniqKey="Mason R" first="Ronald P." last="Mason">Ronald P. Mason</name><affiliation><nlm:aff id="A1">National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Free radical biology & medicine</title><idno type="ISSN">0891-5849</idno><idno type="eISSN">1873-4596</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Ozone exposure effect on free radical-catalyzed oxidation products of lipids, proteins and DNA in the plasma and urine of rats was studied as a continuation of the international Biomarker of Oxidative Stress Study (BOSS) sponsored by NIEHS/NIH. The goal was to identify a biomarker for ozone-induced oxidative stress and to assess whether inconsistent results often reported in the literature might be due to the limitations of the available methods for measuring the various types of oxidative products. The time and dose-dependent effects of ozone exposure on rat plasma lipid hydroperoxides, malondialdehyde, F<sub>2</sub>-isoprostanes, protein carbonyls, methionine oxidation, tyrosine- and phenylalanine oxidation products, as well as urinary malondialdehyde and F<sub>2</sub>-isoprostanes were investigated with various techniques. The criterion used to recognize a marker in the model of ozone exposure was that a significant effect could be identified and measured in a biological fluid seen at both doses at more than one time point. No statistically significant differences between the experimental and control groups at either ozone dose and time point studied could be identified in this study. Tissue samples were not included. Despite all the work accomplished in the BOSS study of ozone, no available product of oxidation in biological fluid has yet met the required criteria of being a biomarker. The current negative findings as a consequence of ozone exposure are of great importance, because they document that in complex systems, as the present in vivo experiment, the assays used may not provide meaningful data of ozone oxidation, especially in human studies.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8709159</journal-id><journal-id journal-id-type="pubmed-jr-id">3902</journal-id><journal-id journal-id-type="nlm-ta">Free Radic Biol Med</journal-id><journal-id journal-id-type="iso-abbrev">Free Radic. Biol. Med.</journal-id><journal-title-group><journal-title>Free radical biology & medicine</journal-title></journal-title-group><issn pub-type="ppub">0891-5849</issn><issn pub-type="epub">1873-4596</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23608465</article-id><article-id pub-id-type="pmc">3968235</article-id><article-id pub-id-type="doi">10.1016/j.freeradbiomed.2013.04.023</article-id><article-id pub-id-type="manuscript">NIHMS525937</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Biomarkers of Oxidative Stress Study V: Ozone exposure of rats and its effect on lipids, proteins and DNA in plasma and urine</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kadiiska</surname><given-names>Maria B.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Basu</surname><given-names>Samar</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Brot</surname><given-names>Nathan</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Cooper</surname><given-names>Christopher</given-names></name><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Csallany</surname><given-names>A. Saari</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Davies</surname><given-names>Michael J.</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>George</surname><given-names>Magdalene M.</given-names></name><xref ref-type="aff" rid="A7">g</xref></contrib><contrib contrib-type="author"><name><surname>Murray</surname><given-names>Dennis M.</given-names></name><xref ref-type="aff" rid="A8">h</xref></contrib><contrib contrib-type="author"><name><surname>Roberts</surname><given-names>L. Jackson</given-names><suffix>II</suffix></name><xref ref-type="aff" rid="A9">i</xref></contrib><contrib contrib-type="author"><name><surname>Shigenaga</surname><given-names>Mark K.</given-names></name><xref ref-type="aff" rid="A10">j</xref></contrib><contrib contrib-type="author"><name><surname>Sohal</surname><given-names>Rajindar S.</given-names></name><xref ref-type="aff" rid="A11">k</xref></contrib><contrib contrib-type="author"><name><surname>Stocker</surname><given-names>Roland</given-names></name><xref ref-type="aff" rid="A12">l</xref></contrib><contrib contrib-type="author"><name><surname>Van Thiel</surname><given-names>David H.</given-names></name><xref ref-type="aff" rid="A7">g</xref></contrib><contrib contrib-type="author"><name><surname>Wiswedel</surname><given-names>Ingrid</given-names></name><xref ref-type="aff" rid="A13">m</xref></contrib><contrib contrib-type="author"><name><surname>Hatch</surname><given-names>Gary E.</given-names></name><xref ref-type="aff" rid="A14">n</xref></contrib><contrib contrib-type="author"><name><surname>Mason</surname><given-names>Ronald P.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib></contrib-group><aff id="A1"><label>a</label>National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA</aff><aff id="A2"><label>b</label>Faculty of Medicine, Uppsala University, Uppsala, Sweden and Biochemistry, Molecular Biology and Nutrition Department, University of Auvergne, Clermont-Ferrand, France</aff><aff id="A3"><label>c</label>Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA</aff><aff id="A4"><label>d</label>School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK</aff><aff id="A5"><label>e</label>Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA</aff><aff id="A6"><label>f</label>The Heart Research Institute, University of Sydney, Sydney, Australia</aff><aff id="A7"><label>g</label>Rush University Medical Center, Chicago, IL USA</aff><aff id="A8"><label>h</label>Northwest Life Science Specialties, LLC., Vancouver, WA, USA</aff><aff id="A9"><label>i</label>Dept. Pharmacology and Medicine, Vanderbilt University, Nashville, TN, USA</aff><aff id="A10"><label>j</label>Children's Hospital Oakland Research Institute, Oakland, CA, USA</aff><aff id="A11"><label>k</label>University of Southern California, Los Angeles, CA, USA</aff><aff id="A12"><label>l</label>Victor Chang Cardiac Research Institute, Darlinghurst, Australia</aff><aff id="A13"><label>m</label>Department of Pathobiochemistry, Medical Faculty, Otto-von-Guericke-University, Magdeburg, Germany</aff><aff id="A14"><label>n</label>United States Environmental Protection Agency, Research Triangle Park, NC, USA</aff><author-notes><corresp id="FN1">Corresponding author: Maria B. Kadiiska, NIEHS/NIH, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709 USA, Phone: 919-541-0201; Fax: 919-541-1043; <email>Kadiiska@niehs.nih.gov</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>5</day><month>2</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>19</day><month>4</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>13</day><month>10</month><year>2014</year></pub-date><volume>0</volume><fpage>408</fpage><lpage>415</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.freeradbiomed.2013.04.023</pmc-comment>
<abstract><p id="P1">Ozone exposure effect on free radical-catalyzed oxidation products of lipids, proteins and DNA in the plasma and urine of rats was studied as a continuation of the international Biomarker of Oxidative Stress Study (BOSS) sponsored by NIEHS/NIH. The goal was to identify a biomarker for ozone-induced oxidative stress and to assess whether inconsistent results often reported in the literature might be due to the limitations of the available methods for measuring the various types of oxidative products. The time and dose-dependent effects of ozone exposure on rat plasma lipid hydroperoxides, malondialdehyde, F<sub>2</sub>-isoprostanes, protein carbonyls, methionine oxidation, tyrosine- and phenylalanine oxidation products, as well as urinary malondialdehyde and F<sub>2</sub>-isoprostanes were investigated with various techniques. The criterion used to recognize a marker in the model of ozone exposure was that a significant effect could be identified and measured in a biological fluid seen at both doses at more than one time point. No statistically significant differences between the experimental and control groups at either ozone dose and time point studied could be identified in this study. Tissue samples were not included. Despite all the work accomplished in the BOSS study of ozone, no available product of oxidation in biological fluid has yet met the required criteria of being a biomarker. The current negative findings as a consequence of ozone exposure are of great importance, because they document that in complex systems, as the present in vivo experiment, the assays used may not provide meaningful data of ozone oxidation, especially in human studies.</p></abstract><kwd-group><kwd>biomarkers</kwd><kwd>oxidative stress</kwd><kwd>ozone exposure</kwd><kwd>rats</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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