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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women<sup><xref ref-type="fn" rid="FN4">†</xref></sup></title><author><name sortKey="Compston, Juliet E" sort="Compston, Juliet E" uniqKey="Compston J" first="Juliet E." last="Compston">Juliet E. Compston</name><affiliation><nlm:aff id="A1">Cambridge Biomedical Campus, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wyman, A" sort="Wyman, A" uniqKey="Wyman A" first="A" last="Wyman">A. Wyman</name><affiliation><nlm:aff id="A2">Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Fitzgerald, Gordon" sort="Fitzgerald, Gordon" uniqKey="Fitzgerald G" first="Gordon" last="Fitzgerald">Gordon Fitzgerald</name><affiliation><nlm:aff id="A2">Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Adachi, Jonathan D" sort="Adachi, Jonathan D" uniqKey="Adachi J" first="Jonathan D." last="Adachi">Jonathan D. Adachi</name><affiliation><nlm:aff id="A3">St Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Chapurlat, Roland D" sort="Chapurlat, Roland D" uniqKey="Chapurlat R" first="Roland D." last="Chapurlat">Roland D. Chapurlat</name><affiliation><nlm:aff id="A4">Division of Rheumatology, INSERM U1033, Université de Lyon, Hôpital E Herriot, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation><nlm:aff id="A5">MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Diez Perez, Adolfo" sort="Diez Perez, Adolfo" uniqKey="Diez Perez A" first="Adolfo" last="Díez-Pérez">Adolfo Díez-Pérez</name><affiliation><nlm:aff id="A6">Hospital del Mar-IMIM-Autonomous University of Barcelona</nlm:aff></affiliation><affiliation><nlm:aff id="A7">RETICEF, Instituto Carlos III, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Gehlbach, Stephen H" sort="Gehlbach, Stephen H" uniqKey="Gehlbach S" first="Stephen H" last="Gehlbach">Stephen H. Gehlbach</name><affiliation><nlm:aff id="A2">Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L." last="Greenspan">Susan L. Greenspan</name><affiliation><nlm:aff id="A8">University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Hooven, Frederick H" sort="Hooven, Frederick H" uniqKey="Hooven F" first="Frederick H." last="Hooven">Frederick H. Hooven</name><affiliation><nlm:aff id="A9">UMASS Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Lacroix, Andrea Z" sort="Lacroix, Andrea Z" uniqKey="Lacroix A" first="Andrea Z." last="Lacroix">Andrea Z. Lacroix</name><affiliation><nlm:aff id="A10">Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="March, Lyn" sort="March, Lyn" uniqKey="March L" first="Lyn" last="March">Lyn March</name><affiliation><nlm:aff id="A11">University of Sydney Institute of Bone and Joint Research and Department of Rheumatology, Royal North Shore Hospital, Australia</nlm:aff></affiliation></author><author><name sortKey="Coen Netelenbos, J" sort="Coen Netelenbos, J" uniqKey="Coen Netelenbos J" first="J." last="Coen Netelenbos">J. Coen Netelenbos</name><affiliation><nlm:aff id="A12">Department of Endocrinology, VU University Medical Center, Amsterdam, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Nieves, Jeri W" sort="Nieves, Jeri W" uniqKey="Nieves J" first="Jeri W." last="Nieves">Jeri W. Nieves</name><affiliation><nlm:aff id="A13">Helen Hayes Hospital and Columbia University, West Haverstraw, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Pfeilschifter, Johannes" sort="Pfeilschifter, Johannes" uniqKey="Pfeilschifter J" first="Johannes" last="Pfeilschifter">Johannes Pfeilschifter</name><affiliation><nlm:aff id="A14">Department of Internal Medicine III, Alfried Krupp Krankenhaus, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Rossini, Maurizio" sort="Rossini, Maurizio" uniqKey="Rossini M" first="Maurizio" last="Rossini">Maurizio Rossini</name><affiliation><nlm:aff id="A15">Rheumatology Section, Department of Medicine, University of Verona, Italy</nlm:aff></affiliation></author><author><name sortKey="Roux, Christian" sort="Roux, Christian" uniqKey="Roux C" first="Christian" last="Roux">Christian Roux</name><affiliation><nlm:aff id="A16">Paris Descartes University, Cochin Hospital, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Saag, Kenneth G" sort="Saag, Kenneth G" uniqKey="Saag K" first="Kenneth G." last="Saag">Kenneth G. Saag</name><affiliation><nlm:aff id="A17">Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA</nlm:aff></affiliation></author><author><name sortKey="Siris, Ethel S" sort="Siris, Ethel S" uniqKey="Siris E" first="Ethel S." last="Siris">Ethel S. Siris</name><affiliation><nlm:aff id="A18">Columbia University Medical Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Silverman, Stuart" sort="Silverman, Stuart" uniqKey="Silverman S" first="Stuart" last="Silverman">Stuart Silverman</name><affiliation><nlm:aff id="A19">Department of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B." last="Watts">Nelson B. Watts</name><affiliation><nlm:aff id="A20">Mercy Health Osteoporosis and Bone Health Services, Cincinnati, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Anderson, Frederick A" sort="Anderson, Frederick A" uniqKey="Anderson F" first="Frederick A." last="Anderson">Frederick A. Anderson</name><affiliation><nlm:aff id="A1">Cambridge Biomedical Campus, Cambridge, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26861139</idno><idno type="pmc">4935593</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935593</idno><idno type="RBID">PMC:4935593</idno><idno type="doi">10.1002/jbmr.2810</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002040</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002040</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women<sup><xref ref-type="fn" rid="FN4">†</xref></sup></title><author><name sortKey="Compston, Juliet E" sort="Compston, Juliet E" uniqKey="Compston J" first="Juliet E." last="Compston">Juliet E. Compston</name><affiliation><nlm:aff id="A1">Cambridge Biomedical Campus, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wyman, A" sort="Wyman, A" uniqKey="Wyman A" first="A" last="Wyman">A. Wyman</name><affiliation><nlm:aff id="A2">Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Fitzgerald, Gordon" sort="Fitzgerald, Gordon" uniqKey="Fitzgerald G" first="Gordon" last="Fitzgerald">Gordon Fitzgerald</name><affiliation><nlm:aff id="A2">Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Adachi, Jonathan D" sort="Adachi, Jonathan D" uniqKey="Adachi J" first="Jonathan D." last="Adachi">Jonathan D. Adachi</name><affiliation><nlm:aff id="A3">St Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Chapurlat, Roland D" sort="Chapurlat, Roland D" uniqKey="Chapurlat R" first="Roland D." last="Chapurlat">Roland D. Chapurlat</name><affiliation><nlm:aff id="A4">Division of Rheumatology, INSERM U1033, Université de Lyon, Hôpital E Herriot, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation><nlm:aff id="A5">MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Diez Perez, Adolfo" sort="Diez Perez, Adolfo" uniqKey="Diez Perez A" first="Adolfo" last="Díez-Pérez">Adolfo Díez-Pérez</name><affiliation><nlm:aff id="A6">Hospital del Mar-IMIM-Autonomous University of Barcelona</nlm:aff></affiliation><affiliation><nlm:aff id="A7">RETICEF, Instituto Carlos III, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Gehlbach, Stephen H" sort="Gehlbach, Stephen H" uniqKey="Gehlbach S" first="Stephen H" last="Gehlbach">Stephen H. Gehlbach</name><affiliation><nlm:aff id="A2">Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L." last="Greenspan">Susan L. Greenspan</name><affiliation><nlm:aff id="A8">University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Hooven, Frederick H" sort="Hooven, Frederick H" uniqKey="Hooven F" first="Frederick H." last="Hooven">Frederick H. Hooven</name><affiliation><nlm:aff id="A9">UMASS Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Lacroix, Andrea Z" sort="Lacroix, Andrea Z" uniqKey="Lacroix A" first="Andrea Z." last="Lacroix">Andrea Z. Lacroix</name><affiliation><nlm:aff id="A10">Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="March, Lyn" sort="March, Lyn" uniqKey="March L" first="Lyn" last="March">Lyn March</name><affiliation><nlm:aff id="A11">University of Sydney Institute of Bone and Joint Research and Department of Rheumatology, Royal North Shore Hospital, Australia</nlm:aff></affiliation></author><author><name sortKey="Coen Netelenbos, J" sort="Coen Netelenbos, J" uniqKey="Coen Netelenbos J" first="J." last="Coen Netelenbos">J. Coen Netelenbos</name><affiliation><nlm:aff id="A12">Department of Endocrinology, VU University Medical Center, Amsterdam, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Nieves, Jeri W" sort="Nieves, Jeri W" uniqKey="Nieves J" first="Jeri W." last="Nieves">Jeri W. Nieves</name><affiliation><nlm:aff id="A13">Helen Hayes Hospital and Columbia University, West Haverstraw, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Pfeilschifter, Johannes" sort="Pfeilschifter, Johannes" uniqKey="Pfeilschifter J" first="Johannes" last="Pfeilschifter">Johannes Pfeilschifter</name><affiliation><nlm:aff id="A14">Department of Internal Medicine III, Alfried Krupp Krankenhaus, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Rossini, Maurizio" sort="Rossini, Maurizio" uniqKey="Rossini M" first="Maurizio" last="Rossini">Maurizio Rossini</name><affiliation><nlm:aff id="A15">Rheumatology Section, Department of Medicine, University of Verona, Italy</nlm:aff></affiliation></author><author><name sortKey="Roux, Christian" sort="Roux, Christian" uniqKey="Roux C" first="Christian" last="Roux">Christian Roux</name><affiliation><nlm:aff id="A16">Paris Descartes University, Cochin Hospital, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Saag, Kenneth G" sort="Saag, Kenneth G" uniqKey="Saag K" first="Kenneth G." last="Saag">Kenneth G. Saag</name><affiliation><nlm:aff id="A17">Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA</nlm:aff></affiliation></author><author><name sortKey="Siris, Ethel S" sort="Siris, Ethel S" uniqKey="Siris E" first="Ethel S." last="Siris">Ethel S. Siris</name><affiliation><nlm:aff id="A18">Columbia University Medical Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Silverman, Stuart" sort="Silverman, Stuart" uniqKey="Silverman S" first="Stuart" last="Silverman">Stuart Silverman</name><affiliation><nlm:aff id="A19">Department of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B." last="Watts">Nelson B. Watts</name><affiliation><nlm:aff id="A20">Mercy Health Osteoporosis and Bone Health Services, Cincinnati, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Anderson, Frederick A" sort="Anderson, Frederick A" uniqKey="Anderson F" first="Frederick A." last="Anderson">Frederick A. Anderson</name><affiliation><nlm:aff id="A1">Cambridge Biomedical Campus, Cambridge, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</title><idno type="ISSN">0884-0431</idno><idno type="eISSN">1523-4681</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Increased fracture risk has been associated with weight loss in postmenopausal women but the time course over which this occurs has not been established. The aim of this study was to examine the effects of unintentional weight loss of ≥10 lb (4.5 kg) in postmenopausal women on fracture risk at multiple sites up to 5 years following weight loss. Using data from the Global Longitudinal Study of Osteoporosis in Women (GLOW) we analyzed the relationships between self-reported unintentional weight loss of ≥10 lb at baseline, year 2, or year 3 and incident clinical fracture in the years following weight loss. Complete data were available in 40,179 women (mean age ± SD 68 ± 8.3 years). Five-year cumulative fracture rate was estimated using the Kaplan-Meier method, and adjusted hazard ratios for weight loss as a time-varying covariate were calculated from Cox multiple regression models. Unintentional weight loss at baseline was associated with a significantly increased risk of fracture of the clavicle, wrist, spine, rib, hip, and pelvis for up to 5 years following weight loss. Adjusted hazard ratios showed a significant association between unintentional weight loss and fracture of the hip, spine, and clavicle within 1 year of weight loss, and these associations were still present at 5 years. These findings demonstrate increased fracture risk at several sites after unintentional weight loss in postmenopausal women. This increase is seen as early as 1 year following weight loss, emphasizing the need for prompt fracture risk assessment and appropriate management to reduce fracture risk in this population.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610640</journal-id><journal-id journal-id-type="pubmed-jr-id">104</journal-id><journal-id journal-id-type="nlm-ta">J Bone Miner Res</journal-id><journal-id journal-id-type="iso-abbrev">J. Bone Miner. Res.</journal-id><journal-title-group><journal-title>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</journal-title></journal-title-group><issn pub-type="ppub">0884-0431</issn><issn pub-type="epub">1523-4681</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26861139</article-id><article-id pub-id-type="pmc">4935593</article-id><article-id pub-id-type="doi">10.1002/jbmr.2810</article-id><article-id pub-id-type="manuscript">NIHMS792313</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women<sup><xref ref-type="fn" rid="FN4">†</xref></sup></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Compston</surname><given-names>Juliet E.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Wyman</surname><given-names>A</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>FitzGerald</surname><given-names>Gordon</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Adachi</surname><given-names>Jonathan D.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Chapurlat</surname><given-names>Roland D.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Cooper</surname><given-names>Cyrus</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Díez-Pérez</surname><given-names>Adolfo</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Gehlbach</surname><given-names>Stephen H</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Greenspan</surname><given-names>Susan L.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Hooven</surname><given-names>Frederick H.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>LaCroix</surname><given-names>Andrea Z.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>March</surname><given-names>Lyn</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Coen Netelenbos</surname><given-names>J.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Nieves</surname><given-names>Jeri W.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Pfeilschifter</surname><given-names>Johannes</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Rossini</surname><given-names>Maurizio</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Roux</surname><given-names>Christian</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Saag</surname><given-names>Kenneth G.</given-names></name><degrees>MD, MSc</degrees><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Siris</surname><given-names>Ethel S.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Silverman</surname><given-names>Stuart</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Watts</surname><given-names>Nelson B.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Anderson</surname><given-names>Frederick A.</given-names><suffix>Jr</suffix></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Cambridge Biomedical Campus, Cambridge, UK</aff><aff id="A2"><label>2</label>Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</aff><aff id="A3"><label>3</label>St Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada</aff><aff id="A4"><label>4</label>Division of Rheumatology, INSERM U1033, Université de Lyon, Hôpital E Herriot, Lyon, France</aff><aff id="A5"><label>5</label>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK</aff><aff id="A6"><label>6</label>Hospital del Mar-IMIM-Autonomous University of Barcelona</aff><aff id="A7"><label>7</label>RETICEF, Instituto Carlos III, Madrid, Spain</aff><aff id="A8"><label>8</label>University of Pittsburgh, Pittsburgh, PA, USA</aff><aff id="A9"><label>9</label>UMASS Medical School, Worcester, MA, USA</aff><aff id="A10"><label>10</label>Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</aff><aff id="A11"><label>11</label>University of Sydney Institute of Bone and Joint Research and Department of Rheumatology, Royal North Shore Hospital, Australia</aff><aff id="A12"><label>12</label>Department of Endocrinology, VU University Medical Center, Amsterdam, Netherlands</aff><aff id="A13"><label>13</label>Helen Hayes Hospital and Columbia University, West Haverstraw, NY, USA</aff><aff id="A14"><label>14</label>Department of Internal Medicine III, Alfried Krupp Krankenhaus, Essen, Germany</aff><aff id="A15"><label>15</label>Rheumatology Section, Department of Medicine, University of Verona, Italy</aff><aff id="A16"><label>16</label>Paris Descartes University, Cochin Hospital, Paris, France</aff><aff id="A17"><label>17</label>Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA</aff><aff id="A18"><label>18</label>Columbia University Medical Center, New York, NY, USA</aff><aff id="A19"><label>19</label>Department of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USA</aff><aff id="A20"><label>20</label>Mercy Health Osteoporosis and Bone Health Services, Cincinnati, OH, USA</aff><author-notes><corresp id="FN1"><label>*</label><bold>Corresponding Author:</bold> Juliet E. Compston, Emeritus Professor of Bone Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0SL, UK, <email>jec1001@cam.ac.uk</email>, Tel: +44 122 333 6867; Fax: +44 1223 336846</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>8</day><month>6</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>07</day><month>7</month><year>2016</year></pub-date><volume>31</volume><issue>7</issue><fpage>1466</fpage><lpage>1472</lpage><pmc-comment>elocation-id from pubmed: 10.1002/jbmr.2810</pmc-comment>
<abstract><p id="P1">Increased fracture risk has been associated with weight loss in postmenopausal women but the time course over which this occurs has not been established. The aim of this study was to examine the effects of unintentional weight loss of ≥10 lb (4.5 kg) in postmenopausal women on fracture risk at multiple sites up to 5 years following weight loss. Using data from the Global Longitudinal Study of Osteoporosis in Women (GLOW) we analyzed the relationships between self-reported unintentional weight loss of ≥10 lb at baseline, year 2, or year 3 and incident clinical fracture in the years following weight loss. Complete data were available in 40,179 women (mean age ± SD 68 ± 8.3 years). Five-year cumulative fracture rate was estimated using the Kaplan-Meier method, and adjusted hazard ratios for weight loss as a time-varying covariate were calculated from Cox multiple regression models. Unintentional weight loss at baseline was associated with a significantly increased risk of fracture of the clavicle, wrist, spine, rib, hip, and pelvis for up to 5 years following weight loss. Adjusted hazard ratios showed a significant association between unintentional weight loss and fracture of the hip, spine, and clavicle within 1 year of weight loss, and these associations were still present at 5 years. These findings demonstrate increased fracture risk at several sites after unintentional weight loss in postmenopausal women. This increase is seen as early as 1 year following weight loss, emphasizing the need for prompt fracture risk assessment and appropriate management to reduce fracture risk in this population.</p></abstract><kwd-group><kwd>WEIGHT LOSS</kwd><kwd>FRACTURE</kwd><kwd>POSTMENOPAUSAL WOMEN</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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