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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Relationship of Weight, Height, and Body Mass Index with Fracture Risk at Different Sites in Postmenopausal Women: The Global Longitudinal study of Osteoporosis in Women (GLOW)</title><author><name sortKey="Compston, Juliet E" sort="Compston, Juliet E" uniqKey="Compston J" first="Juliet E" last="Compston">Juliet E. Compston</name><affiliation><nlm:aff id="A1">Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Flahive, Julie" sort="Flahive, Julie" uniqKey="Flahive J" first="Julie" last="Flahive">Julie Flahive</name><affiliation><nlm:aff id="A2">Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Hosmer, David W" sort="Hosmer, David W" uniqKey="Hosmer D" first="David W" last="Hosmer">David W. Hosmer</name><affiliation><nlm:aff id="A3">Biostatistics, University of Massachusetts, Amherst, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B" last="Watts">Nelson B. Watts</name><affiliation><nlm:aff id="A4">Mercy Health Osteoporosis and Bone Health Services, Cincinnati, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Siris, Ethel S" sort="Siris, Ethel S" uniqKey="Siris E" first="Ethel S" last="Siris">Ethel S. Siris</name><affiliation><nlm:aff id="A5">Department of Medicine, Columbia University Medical Center, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Silverman, Stuart" sort="Silverman, Stuart" uniqKey="Silverman S" first="Stuart" last="Silverman">Stuart Silverman</name><affiliation><nlm:aff id="A6">Department of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Saag, Kenneth G" sort="Saag, Kenneth G" uniqKey="Saag K" first="Kenneth G" last="Saag">Kenneth G. Saag</name><affiliation><nlm:aff id="A7">Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff></affiliation></author><author><name sortKey="Roux, Christian" sort="Roux, Christian" uniqKey="Roux C" first="Christian" last="Roux">Christian Roux</name><affiliation><nlm:aff id="A8">Paris Descartes University, Cochin Hospital, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Rossini, Maurizio" sort="Rossini, Maurizio" uniqKey="Rossini M" first="Maurizio" last="Rossini">Maurizio Rossini</name><affiliation><nlm:aff id="A9">Department of Rheumatology, University of Verona, Ospedale, Verona, Valeggio, Italy</nlm:aff></affiliation></author><author><name sortKey="Pfeilschifter, Johannes" sort="Pfeilschifter, Johannes" uniqKey="Pfeilschifter J" first="Johannes" last="Pfeilschifter">Johannes Pfeilschifter</name><affiliation><nlm:aff id="A10">Department of Internal Medicine III, Alfried Krupp Krankenhaus, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Nieves, Jeri W" sort="Nieves, Jeri W" uniqKey="Nieves J" first="Jeri W" last="Nieves">Jeri W. Nieves</name><affiliation><nlm:aff id="A11">Helen Hayes Hospital and Columbia University, West Haverstraw, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Netelenbos, J Coen" sort="Netelenbos, J Coen" uniqKey="Netelenbos J" first="J Coen" last="Netelenbos">J Coen Netelenbos</name><affiliation><nlm:aff id="A12">Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="March, Lyn" sort="March, Lyn" uniqKey="March L" first="Lyn" last="March">Lyn March</name><affiliation><nlm:aff id="A13">University of Sydney Institute of Bone and Joint Research and Department of Rheumatology, Royal North Shore Hospital, Australia</nlm:aff></affiliation></author><author><name sortKey="Lacroix, Andrea Z" sort="Lacroix, Andrea Z" uniqKey="Lacroix A" first="Andrea Z" last="Lacroix">Andrea Z. Lacroix</name><affiliation><nlm:aff id="A14">Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Hooven, Frederick H" sort="Hooven, Frederick H" uniqKey="Hooven F" first="Frederick H" last="Hooven">Frederick H. Hooven</name><affiliation><nlm:aff id="A2">Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L" last="Greenspan">Susan L. Greenspan</name><affiliation><nlm:aff id="A15">University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Gehlbach, Stephen H" sort="Gehlbach, Stephen H" uniqKey="Gehlbach S" first="Stephen H" last="Gehlbach">Stephen H. Gehlbach</name><affiliation><nlm:aff id="A2">Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Diez Perez, Adolfo" sort="Diez Perez, Adolfo" uniqKey="Diez Perez A" first="Adolfo" last="Díez-Pérez">Adolfo Díez-Pérez</name><affiliation><nlm:aff id="A16">Hospital del Mar-IMIM-Autonomous University of Barcelona, Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A17">RETICEF, ISCIII Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation><nlm:aff id="A18">MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Chapurlat, Roland D" sort="Chapurlat, Roland D" uniqKey="Chapurlat R" first="Roland D" last="Chapurlat">Roland D. Chapurlat</name><affiliation><nlm:aff id="A19">Division of Rheumatology, INSERM UMR 1033, Université de Lyon, Hospices Civils de Lyon, Hôpital E Herriot, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name><affiliation><nlm:aff id="A20">Universiteit Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Anderson, Frederick A" sort="Anderson, Frederick A" uniqKey="Anderson F" first="Frederick A" last="Anderson">Frederick A. Anderson</name><affiliation><nlm:aff id="A2">Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Adami, Silvano" sort="Adami, Silvano" uniqKey="Adami S" first="Silvano" last="Adami">Silvano Adami</name><affiliation><nlm:aff id="A9">Department of Rheumatology, University of Verona, Ospedale, Verona, Valeggio, Italy</nlm:aff></affiliation></author><author><name sortKey="Adachi, Jonathan D" sort="Adachi, Jonathan D" uniqKey="Adachi J" first="Jonathan D" last="Adachi">Jonathan D. Adachi</name><affiliation><nlm:aff id="A21">St Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23873741</idno><idno type="pmc">4878680</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878680</idno><idno type="RBID">PMC:4878680</idno><idno type="doi">10.1002/jbmr.2051</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002039</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002039</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Relationship of Weight, Height, and Body Mass Index with Fracture Risk at Different Sites in Postmenopausal Women: The Global Longitudinal study of Osteoporosis in Women (GLOW)</title><author><name sortKey="Compston, Juliet E" sort="Compston, Juliet E" uniqKey="Compston J" first="Juliet E" last="Compston">Juliet E. Compston</name><affiliation><nlm:aff id="A1">Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Flahive, Julie" sort="Flahive, Julie" uniqKey="Flahive J" first="Julie" last="Flahive">Julie Flahive</name><affiliation><nlm:aff id="A2">Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Hosmer, David W" sort="Hosmer, David W" uniqKey="Hosmer D" first="David W" last="Hosmer">David W. Hosmer</name><affiliation><nlm:aff id="A3">Biostatistics, University of Massachusetts, Amherst, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B" last="Watts">Nelson B. Watts</name><affiliation><nlm:aff id="A4">Mercy Health Osteoporosis and Bone Health Services, Cincinnati, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Siris, Ethel S" sort="Siris, Ethel S" uniqKey="Siris E" first="Ethel S" last="Siris">Ethel S. Siris</name><affiliation><nlm:aff id="A5">Department of Medicine, Columbia University Medical Center, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Silverman, Stuart" sort="Silverman, Stuart" uniqKey="Silverman S" first="Stuart" last="Silverman">Stuart Silverman</name><affiliation><nlm:aff id="A6">Department of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Saag, Kenneth G" sort="Saag, Kenneth G" uniqKey="Saag K" first="Kenneth G" last="Saag">Kenneth G. Saag</name><affiliation><nlm:aff id="A7">Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff></affiliation></author><author><name sortKey="Roux, Christian" sort="Roux, Christian" uniqKey="Roux C" first="Christian" last="Roux">Christian Roux</name><affiliation><nlm:aff id="A8">Paris Descartes University, Cochin Hospital, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Rossini, Maurizio" sort="Rossini, Maurizio" uniqKey="Rossini M" first="Maurizio" last="Rossini">Maurizio Rossini</name><affiliation><nlm:aff id="A9">Department of Rheumatology, University of Verona, Ospedale, Verona, Valeggio, Italy</nlm:aff></affiliation></author><author><name sortKey="Pfeilschifter, Johannes" sort="Pfeilschifter, Johannes" uniqKey="Pfeilschifter J" first="Johannes" last="Pfeilschifter">Johannes Pfeilschifter</name><affiliation><nlm:aff id="A10">Department of Internal Medicine III, Alfried Krupp Krankenhaus, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Nieves, Jeri W" sort="Nieves, Jeri W" uniqKey="Nieves J" first="Jeri W" last="Nieves">Jeri W. Nieves</name><affiliation><nlm:aff id="A11">Helen Hayes Hospital and Columbia University, West Haverstraw, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Netelenbos, J Coen" sort="Netelenbos, J Coen" uniqKey="Netelenbos J" first="J Coen" last="Netelenbos">J Coen Netelenbos</name><affiliation><nlm:aff id="A12">Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="March, Lyn" sort="March, Lyn" uniqKey="March L" first="Lyn" last="March">Lyn March</name><affiliation><nlm:aff id="A13">University of Sydney Institute of Bone and Joint Research and Department of Rheumatology, Royal North Shore Hospital, Australia</nlm:aff></affiliation></author><author><name sortKey="Lacroix, Andrea Z" sort="Lacroix, Andrea Z" uniqKey="Lacroix A" first="Andrea Z" last="Lacroix">Andrea Z. Lacroix</name><affiliation><nlm:aff id="A14">Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Hooven, Frederick H" sort="Hooven, Frederick H" uniqKey="Hooven F" first="Frederick H" last="Hooven">Frederick H. Hooven</name><affiliation><nlm:aff id="A2">Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L" last="Greenspan">Susan L. Greenspan</name><affiliation><nlm:aff id="A15">University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Gehlbach, Stephen H" sort="Gehlbach, Stephen H" uniqKey="Gehlbach S" first="Stephen H" last="Gehlbach">Stephen H. Gehlbach</name><affiliation><nlm:aff id="A2">Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Diez Perez, Adolfo" sort="Diez Perez, Adolfo" uniqKey="Diez Perez A" first="Adolfo" last="Díez-Pérez">Adolfo Díez-Pérez</name><affiliation><nlm:aff id="A16">Hospital del Mar-IMIM-Autonomous University of Barcelona, Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A17">RETICEF, ISCIII Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation><nlm:aff id="A18">MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Chapurlat, Roland D" sort="Chapurlat, Roland D" uniqKey="Chapurlat R" first="Roland D" last="Chapurlat">Roland D. Chapurlat</name><affiliation><nlm:aff id="A19">Division of Rheumatology, INSERM UMR 1033, Université de Lyon, Hospices Civils de Lyon, Hôpital E Herriot, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name><affiliation><nlm:aff id="A20">Universiteit Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Anderson, Frederick A" sort="Anderson, Frederick A" uniqKey="Anderson F" first="Frederick A" last="Anderson">Frederick A. Anderson</name><affiliation><nlm:aff id="A2">Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Adami, Silvano" sort="Adami, Silvano" uniqKey="Adami S" first="Silvano" last="Adami">Silvano Adami</name><affiliation><nlm:aff id="A9">Department of Rheumatology, University of Verona, Ospedale, Verona, Valeggio, Italy</nlm:aff></affiliation></author><author><name sortKey="Adachi, Jonathan D" sort="Adachi, Jonathan D" uniqKey="Adachi J" first="Jonathan D" last="Adachi">Jonathan D. Adachi</name><affiliation><nlm:aff id="A21">St Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</title><idno type="ISSN">0884-0431</idno><idno type="eISSN">1523-4681</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Low body mass index (BMI) is a well-established risk factor for fracture in postmenopausal women. Height and obesity have also been associated with increased fracture risk at some sites. We investigated the relationships of weight, BMI, and height with incident clinical fracture in <bold>a practice-based cohort of</bold> postmenopausal women participating in the Global Longitudinal study of Osteoporosis in Women (GLOW). Data were collected at baseline and 1, 2, and 3 years. For hip, spine, wrist, pelvis, rib, upper arm/shoulder, clavicle, ankle, lower leg, and upper leg fractures, we modeled the time to incident self-reported fracture over a 3-year period using the Cox proportional hazards model and fitted the best linear or non-linear models containing height, weight, and BMI. Of 52,939 women, 3628 (6.9%) reported an incident clinical fracture during the 3-year follow-up period. Linear BMI showed a significant inverse association with hip, clinical spine, and wrist fractures: adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) per increase of 5 kg/m<sup>2</sup> were 0.80 (0.71–0.90), 0.83 (0.76–0.92), and 0.88 (0.83–0.94), respectively (all <italic>p</italic> < 0.001). For ankle fractures, linear weight showed a significant positive association: adjusted HR per 5-kg increase 1.05 (1.02–1.07) (<italic>p</italic> < 0.001). For upper arm/shoulder and clavicle fractures, only linear height was significantly associated: adjusted HRs per 10-cm increase were 0.85 (0.75–0.97) (<italic>p</italic> = 0.02) and 0.73 (0.57–0.92) (<italic>p</italic> = 0.009), respectively. For pelvic and rib fractures, the best models were for non-linear BMI or weight (<italic>p</italic> = 0.05 and 0.03, respectively), with inverse associations at low BMI/body weight and positive associations at high values. These data demonstrate that the relationships between fracture and weight, BMI, and height are site-specific. The different associations may be mediated, at least in part, by effects on bone mineral density, bone structure and geometry, and patterns of falling.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610640</journal-id><journal-id journal-id-type="pubmed-jr-id">104</journal-id><journal-id journal-id-type="nlm-ta">J Bone Miner Res</journal-id><journal-id journal-id-type="iso-abbrev">J. Bone Miner. Res.</journal-id><journal-title-group><journal-title>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</journal-title></journal-title-group><issn pub-type="ppub">0884-0431</issn><issn pub-type="epub">1523-4681</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23873741</article-id><article-id pub-id-type="pmc">4878680</article-id><article-id pub-id-type="doi">10.1002/jbmr.2051</article-id><article-id pub-id-type="manuscript">NIHMS786625</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Relationship of Weight, Height, and Body Mass Index with Fracture Risk at Different Sites in Postmenopausal Women: The Global Longitudinal study of Osteoporosis in Women (GLOW)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Compston</surname><given-names>Juliet E</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Flahive</surname><given-names>Julie</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hosmer</surname><given-names>David W</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Watts</surname><given-names>Nelson B</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Siris</surname><given-names>Ethel S</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Silverman</surname><given-names>Stuart</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Saag</surname><given-names>Kenneth G</given-names></name><degrees>MD, MSc</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Roux</surname><given-names>Christian</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Rossini</surname><given-names>Maurizio</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Pfeilschifter</surname><given-names>Johannes</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Nieves</surname><given-names>Jeri W</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Netelenbos</surname><given-names>J Coen</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>March</surname><given-names>Lyn</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>LaCroix</surname><given-names>Andrea Z</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Hooven</surname><given-names>Frederick H</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Greenspan</surname><given-names>Susan L</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Gehlbach</surname><given-names>Stephen H</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Díez-Pérez</surname><given-names>Adolfo</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Cooper</surname><given-names>Cyrus</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Chapurlat</surname><given-names>Roland D</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Boonen</surname><given-names>Steven</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Anderson</surname><given-names>Frederick A</given-names><suffix>Jr</suffix></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Adami</surname><given-names>Silvano</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Adachi</surname><given-names>Jonathan D</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><collab>GLOW Investigators</collab></contrib></contrib-group><aff id="A1"><label>1</label>Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK</aff><aff id="A2"><label>2</label>Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</aff><aff id="A3"><label>3</label>Biostatistics, University of Massachusetts, Amherst, MA, USA</aff><aff id="A4"><label>4</label>Mercy Health Osteoporosis and Bone Health Services, Cincinnati, OH, USA</aff><aff id="A5"><label>5</label>Department of Medicine, Columbia University Medical Center, NY, USA</aff><aff id="A6"><label>6</label>Department of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA</aff><aff id="A7"><label>7</label>Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA</aff><aff id="A8"><label>8</label>Paris Descartes University, Cochin Hospital, Paris, France</aff><aff id="A9"><label>9</label>Department of Rheumatology, University of Verona, Ospedale, Verona, Valeggio, Italy</aff><aff id="A10"><label>10</label>Department of Internal Medicine III, Alfried Krupp Krankenhaus, Essen, Germany</aff><aff id="A11"><label>11</label>Helen Hayes Hospital and Columbia University, West Haverstraw, NY, USA</aff><aff id="A12"><label>12</label>Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands</aff><aff id="A13"><label>13</label>University of Sydney Institute of Bone and Joint Research and Department of Rheumatology, Royal North Shore Hospital, Australia</aff><aff id="A14"><label>14</label>Fred Hutchinson Cancer Research Center, Seattle, WA, USA</aff><aff id="A15"><label>15</label>University of Pittsburgh, Pittsburgh, PA, USA</aff><aff id="A16"><label>16</label>Hospital del Mar-IMIM-Autonomous University of Barcelona, Barcelona, Spain</aff><aff id="A17"><label>17</label>RETICEF, ISCIII Madrid, Spain</aff><aff id="A18"><label>18</label>MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK</aff><aff id="A19"><label>19</label>Division of Rheumatology, INSERM UMR 1033, Université de Lyon, Hospices Civils de Lyon, Hôpital E Herriot, Lyon, France</aff><aff id="A20"><label>20</label>Universiteit Leuven, Leuven, Belgium</aff><aff id="A21"><label>21</label>St Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada</aff><author-notes><corresp id="CR1">Address correspondence to: Professor J E Compston, Emeritus Professor of Bone Medicine, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Box 157, Cambridge CB2 0QQ, UK. <email>jec1001@cam.ac.uk</email>, Tel: +44 1223 336840. Fax: +44 1223 336846.</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>17</day><month>5</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>24</day><month>5</month><year>2016</year></pub-date><volume>29</volume><issue>2</issue><fpage>487</fpage><lpage>493</lpage><pmc-comment>elocation-id from pubmed: 10.1002/jbmr.2051</pmc-comment>
<abstract><p id="P1">Low body mass index (BMI) is a well-established risk factor for fracture in postmenopausal women. Height and obesity have also been associated with increased fracture risk at some sites. We investigated the relationships of weight, BMI, and height with incident clinical fracture in <bold>a practice-based cohort of</bold> postmenopausal women participating in the Global Longitudinal study of Osteoporosis in Women (GLOW). Data were collected at baseline and 1, 2, and 3 years. For hip, spine, wrist, pelvis, rib, upper arm/shoulder, clavicle, ankle, lower leg, and upper leg fractures, we modeled the time to incident self-reported fracture over a 3-year period using the Cox proportional hazards model and fitted the best linear or non-linear models containing height, weight, and BMI. Of 52,939 women, 3628 (6.9%) reported an incident clinical fracture during the 3-year follow-up period. Linear BMI showed a significant inverse association with hip, clinical spine, and wrist fractures: adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) per increase of 5 kg/m<sup>2</sup> were 0.80 (0.71–0.90), 0.83 (0.76–0.92), and 0.88 (0.83–0.94), respectively (all <italic>p</italic> < 0.001). For ankle fractures, linear weight showed a significant positive association: adjusted HR per 5-kg increase 1.05 (1.02–1.07) (<italic>p</italic> < 0.001). For upper arm/shoulder and clavicle fractures, only linear height was significantly associated: adjusted HRs per 10-cm increase were 0.85 (0.75–0.97) (<italic>p</italic> = 0.02) and 0.73 (0.57–0.92) (<italic>p</italic> = 0.009), respectively. For pelvic and rib fractures, the best models were for non-linear BMI or weight (<italic>p</italic> = 0.05 and 0.03, respectively), with inverse associations at low BMI/body weight and positive associations at high values. These data demonstrate that the relationships between fracture and weight, BMI, and height are site-specific. The different associations may be mediated, at least in part, by effects on bone mineral density, bone structure and geometry, and patterns of falling.</p></abstract><kwd-group><kwd>FRACTURES</kwd><kwd>OBESITY</kwd><kwd>POSTMENOPAUSAL WOMEN</kwd><kwd>BMI</kwd><kwd>OSTEOPOROSIS</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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