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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Regional differences in treatment for osteoporosis. The Global Longitudinal Study of Osteoporosis in Women (GLOW)</title><author><name sortKey="Diez Perez, Adolfo" sort="Diez Perez, Adolfo" uniqKey="Diez Perez A" first="Adolfo" last="Díez-Pérez">Adolfo Díez-Pérez</name><affiliation><nlm:aff id="A1"> Hospital del Mar-IMIM, Autonomous University of Barcelona and RETICEF, Instituto Carlos III, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Hooven, Frederick H" sort="Hooven, Frederick H" uniqKey="Hooven F" first="Frederick H." last="Hooven">Frederick H. Hooven</name><affiliation><nlm:aff id="A2"> Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Adachi, Jonathan D" sort="Adachi, Jonathan D" uniqKey="Adachi J" first="Jonathan D." last="Adachi">Jonathan D. Adachi</name><affiliation><nlm:aff id="A3"> St Joseph's Hospital, McMaster University, Hamilton, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Adami, Silvano" sort="Adami, Silvano" uniqKey="Adami S" first="Silvano" last="Adami">Silvano Adami</name><affiliation><nlm:aff id="A4"> Department of Rheumatology, University of Verona, Ospedale, Verona, Valeggio, Italy</nlm:aff></affiliation></author><author><name sortKey="Anderson, Frederick A" sort="Anderson, Frederick A" uniqKey="Anderson F" first="Frederick A." last="Anderson">Frederick A. Anderson</name><affiliation><nlm:aff id="A2"> Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name><affiliation><nlm:aff id="A5"> Leuven University Centre for Metabolic Bone Diseases, Division of Geriatric Medicine, Katholieke Universiteit Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Chapurlat, Roland" sort="Chapurlat, Roland" uniqKey="Chapurlat R" first="Roland" last="Chapurlat">Roland Chapurlat</name><affiliation><nlm:aff id="A6"> INSERM Research Unit 831, Université de Lyon, Department of Orthopedics and Rheumatology, Hôpital E Herriot, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Compston, Juliet E" sort="Compston, Juliet E" uniqKey="Compston J" first="Juliet E." last="Compston">Juliet E. Compston</name><affiliation><nlm:aff id="A7"> University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation><nlm:aff id="A8"> MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital and Norman Collisson Chair of Musculoskeletal Sciences, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Delmas, Pierre" sort="Delmas, Pierre" uniqKey="Delmas P" first="Pierre" last="Delmas">Pierre Delmas</name><affiliation><nlm:aff id="A9"> Hôpital Edouard Herriot, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L." last="Greenspan">Susan L. Greenspan</name><affiliation><nlm:aff id="A10"> University of Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Lacroix, Andrea Z" sort="Lacroix, Andrea Z" uniqKey="Lacroix A" first="Andrea Z." last="Lacroix">Andrea Z. Lacroix</name><affiliation><nlm:aff id="A11"> Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Lindsay, Robert" sort="Lindsay, Robert" uniqKey="Lindsay R" first="Robert" last="Lindsay">Robert Lindsay</name><affiliation><nlm:aff id="A12"> Regional Bone Center, Helen Hayes Hospital, West Haverstraw, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Netelenbos, J Coen" sort="Netelenbos, J Coen" uniqKey="Netelenbos J" first="J. Coen" last="Netelenbos">J. Coen Netelenbos</name><affiliation><nlm:aff id="A13"> Department of Endocrinology, VU University Medical Center, Amsterdam, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pfeilschifter, Johannes" sort="Pfeilschifter, Johannes" uniqKey="Pfeilschifter J" first="Johannes" last="Pfeilschifter">Johannes Pfeilschifter</name><affiliation><nlm:aff id="A14"> Alfried Krupp Krankenhaus, Department of Internal Medicine III, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Roux, Christian" sort="Roux, Christian" uniqKey="Roux C" first="Christian" last="Roux">Christian Roux</name><affiliation><nlm:aff id="A15"> Paris Descartes University, Cochin Hospital, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Saag, Kenneth G" sort="Saag, Kenneth G" uniqKey="Saag K" first="Kenneth G." last="Saag">Kenneth G. Saag</name><affiliation><nlm:aff id="A16"> University of Alabama-Birmingham, Division of Clinical Immunology and Rheumatology, Birmingham, AL, USA</nlm:aff></affiliation></author><author><name sortKey="Sambrook, Philip" sort="Sambrook, Philip" uniqKey="Sambrook P" first="Philip" last="Sambrook">Philip Sambrook</name><affiliation><nlm:aff id="A17"> University of Sydney-Royal North Shore Hospital, St. Leonards, Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Silverman, Stuart" sort="Silverman, Stuart" uniqKey="Silverman S" first="Stuart" last="Silverman">Stuart Silverman</name><affiliation><nlm:aff id="A18"> Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Siris, Ethel S" sort="Siris, Ethel S" uniqKey="Siris E" first="Ethel S." last="Siris">Ethel S. Siris</name><affiliation><nlm:aff id="A19"> Columbia University Medical Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B." last="Watts">Nelson B. Watts</name><affiliation><nlm:aff id="A20"> Bone Health and Osteoporosis Center, University of Cincinnati, Cincinnati, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Nika, Grigor" sort="Nika, Grigor" uniqKey="Nika G" first="Grigor" last="Nika">Grigor Nika</name><affiliation><nlm:aff id="A2"> Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Gehlbach, Stephen H" sort="Gehlbach, Stephen H" uniqKey="Gehlbach S" first="Stephen H." last="Gehlbach">Stephen H. Gehlbach</name><affiliation><nlm:aff id="A2"> Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21605715</idno><idno type="pmc">4897770</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897770</idno><idno type="RBID">PMC:4897770</idno><idno type="doi">10.1016/j.bone.2011.05.007</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002030</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002030</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Regional differences in treatment for osteoporosis. The Global Longitudinal Study of Osteoporosis in Women (GLOW)</title><author><name sortKey="Diez Perez, Adolfo" sort="Diez Perez, Adolfo" uniqKey="Diez Perez A" first="Adolfo" last="Díez-Pérez">Adolfo Díez-Pérez</name><affiliation><nlm:aff id="A1"> Hospital del Mar-IMIM, Autonomous University of Barcelona and RETICEF, Instituto Carlos III, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Hooven, Frederick H" sort="Hooven, Frederick H" uniqKey="Hooven F" first="Frederick H." last="Hooven">Frederick H. Hooven</name><affiliation><nlm:aff id="A2"> Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Adachi, Jonathan D" sort="Adachi, Jonathan D" uniqKey="Adachi J" first="Jonathan D." last="Adachi">Jonathan D. Adachi</name><affiliation><nlm:aff id="A3"> St Joseph's Hospital, McMaster University, Hamilton, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Adami, Silvano" sort="Adami, Silvano" uniqKey="Adami S" first="Silvano" last="Adami">Silvano Adami</name><affiliation><nlm:aff id="A4"> Department of Rheumatology, University of Verona, Ospedale, Verona, Valeggio, Italy</nlm:aff></affiliation></author><author><name sortKey="Anderson, Frederick A" sort="Anderson, Frederick A" uniqKey="Anderson F" first="Frederick A." last="Anderson">Frederick A. Anderson</name><affiliation><nlm:aff id="A2"> Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name><affiliation><nlm:aff id="A5"> Leuven University Centre for Metabolic Bone Diseases, Division of Geriatric Medicine, Katholieke Universiteit Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Chapurlat, Roland" sort="Chapurlat, Roland" uniqKey="Chapurlat R" first="Roland" last="Chapurlat">Roland Chapurlat</name><affiliation><nlm:aff id="A6"> INSERM Research Unit 831, Université de Lyon, Department of Orthopedics and Rheumatology, Hôpital E Herriot, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Compston, Juliet E" sort="Compston, Juliet E" uniqKey="Compston J" first="Juliet E." last="Compston">Juliet E. Compston</name><affiliation><nlm:aff id="A7"> University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation><nlm:aff id="A8"> MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital and Norman Collisson Chair of Musculoskeletal Sciences, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Delmas, Pierre" sort="Delmas, Pierre" uniqKey="Delmas P" first="Pierre" last="Delmas">Pierre Delmas</name><affiliation><nlm:aff id="A9"> Hôpital Edouard Herriot, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L." last="Greenspan">Susan L. Greenspan</name><affiliation><nlm:aff id="A10"> University of Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Lacroix, Andrea Z" sort="Lacroix, Andrea Z" uniqKey="Lacroix A" first="Andrea Z." last="Lacroix">Andrea Z. Lacroix</name><affiliation><nlm:aff id="A11"> Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Lindsay, Robert" sort="Lindsay, Robert" uniqKey="Lindsay R" first="Robert" last="Lindsay">Robert Lindsay</name><affiliation><nlm:aff id="A12"> Regional Bone Center, Helen Hayes Hospital, West Haverstraw, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Netelenbos, J Coen" sort="Netelenbos, J Coen" uniqKey="Netelenbos J" first="J. Coen" last="Netelenbos">J. Coen Netelenbos</name><affiliation><nlm:aff id="A13"> Department of Endocrinology, VU University Medical Center, Amsterdam, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pfeilschifter, Johannes" sort="Pfeilschifter, Johannes" uniqKey="Pfeilschifter J" first="Johannes" last="Pfeilschifter">Johannes Pfeilschifter</name><affiliation><nlm:aff id="A14"> Alfried Krupp Krankenhaus, Department of Internal Medicine III, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Roux, Christian" sort="Roux, Christian" uniqKey="Roux C" first="Christian" last="Roux">Christian Roux</name><affiliation><nlm:aff id="A15"> Paris Descartes University, Cochin Hospital, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Saag, Kenneth G" sort="Saag, Kenneth G" uniqKey="Saag K" first="Kenneth G." last="Saag">Kenneth G. Saag</name><affiliation><nlm:aff id="A16"> University of Alabama-Birmingham, Division of Clinical Immunology and Rheumatology, Birmingham, AL, USA</nlm:aff></affiliation></author><author><name sortKey="Sambrook, Philip" sort="Sambrook, Philip" uniqKey="Sambrook P" first="Philip" last="Sambrook">Philip Sambrook</name><affiliation><nlm:aff id="A17"> University of Sydney-Royal North Shore Hospital, St. Leonards, Sydney, NSW, Australia</nlm:aff></affiliation></author><author><name sortKey="Silverman, Stuart" sort="Silverman, Stuart" uniqKey="Silverman S" first="Stuart" last="Silverman">Stuart Silverman</name><affiliation><nlm:aff id="A18"> Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Siris, Ethel S" sort="Siris, Ethel S" uniqKey="Siris E" first="Ethel S." last="Siris">Ethel S. Siris</name><affiliation><nlm:aff id="A19"> Columbia University Medical Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B." last="Watts">Nelson B. Watts</name><affiliation><nlm:aff id="A20"> Bone Health and Osteoporosis Center, University of Cincinnati, Cincinnati, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Nika, Grigor" sort="Nika, Grigor" uniqKey="Nika G" first="Grigor" last="Nika">Grigor Nika</name><affiliation><nlm:aff id="A2"> Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Gehlbach, Stephen H" sort="Gehlbach, Stephen H" uniqKey="Gehlbach S" first="Stephen H." last="Gehlbach">Stephen H. Gehlbach</name><affiliation><nlm:aff id="A2"> Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Bone</title><idno type="ISSN">8756-3282</idno><idno type="eISSN">1873-2763</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">To determine if important geographic differences exist in treatment rates for osteoporosis and whether this variation can be explained by regional variation in risk factors.</p></sec><sec id="S2"><title>Methods</title><p id="P2">The Global Longitudinal Study of Osteoporosis in Women is an observational study of women ≥55 years sampled from primary care practices in 10 countries. Self-administered questionnaires were used to collect data on patient characteristics, risk factors for fracture, previous fractures, anti-osteoporosis medication, and health status.</p></sec><sec id="S3"><title>Results</title><p id="P3">Among 58,009 women, current anti-osteoporosis medication use was lowest in Northern Europe (16%) and highest in USA and Australia (32%). Between 48% (USA, Southern Europe) and 68% (Northern Europe) of women aged ≥65 years with a history of spine or hip fracture since age 45 were untreated. Among women with osteoporosis, the percentage of treated cases was lowest in Europe (45– 52% versus 62–65% elsewhere). Women with osteopenia and no other risk factors were treated with anti-osteoporosis medication most frequently in USA (31%) and Canada (31%), and least frequently in Southern Europe (12%), Northern Europe (13%), and Australia (16%). After adjusting for risk factors, US women were threefold as likely to be treated with anti-osteoporosis medication as Northern European women (odds ratio 2.8; 95% confidence interval 2.5–3.1) and 1.5 times as likely to be treated as Southern European women (1.5, 1.4–1.6). Up to half of women reporting previous hip or spine fracture did not receive treatment.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The likelihood of being treated for osteoporosis differed between regions, and cannot be explained by variation in risk factors. Many women at risk of fracture do not receive prophylaxis.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8504048</journal-id><journal-id journal-id-type="pubmed-jr-id">1710</journal-id><journal-id journal-id-type="nlm-ta">Bone</journal-id><journal-id journal-id-type="iso-abbrev">Bone</journal-id><journal-title-group><journal-title>Bone</journal-title></journal-title-group><issn pub-type="ppub">8756-3282</issn><issn pub-type="epub">1873-2763</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21605715</article-id><article-id pub-id-type="pmc">4897770</article-id><article-id pub-id-type="doi">10.1016/j.bone.2011.05.007</article-id><article-id pub-id-type="manuscript">NIHMS786574</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Regional differences in treatment for osteoporosis. The Global Longitudinal Study of Osteoporosis in Women (GLOW)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Díez-Pérez</surname><given-names>Adolfo</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib><contrib contrib-type="author"><name><surname>Hooven</surname><given-names>Frederick H.</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Adachi</surname><given-names>Jonathan D.</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Adami</surname><given-names>Silvano</given-names></name><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Anderson</surname><given-names>Frederick A.</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Boonen</surname><given-names>Steven</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Chapurlat</surname><given-names>Roland</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Compston</surname><given-names>Juliet E.</given-names></name><xref ref-type="aff" rid="A7">g</xref></contrib><contrib contrib-type="author"><name><surname>Cooper</surname><given-names>Cyrus</given-names></name><xref ref-type="aff" rid="A8">h</xref></contrib><contrib contrib-type="author"><name><surname>Delmas</surname><given-names>Pierre</given-names></name><xref ref-type="aff" rid="A9">i</xref></contrib><contrib contrib-type="author"><name><surname>Greenspan</surname><given-names>Susan L.</given-names></name><xref ref-type="aff" rid="A10">j</xref></contrib><contrib contrib-type="author"><name><surname>LaCroix</surname><given-names>Andrea Z.</given-names></name><xref ref-type="aff" rid="A11">k</xref></contrib><contrib contrib-type="author"><name><surname>Lindsay</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="A12">l</xref></contrib><contrib contrib-type="author"><name><surname>Netelenbos</surname><given-names>J. Coen</given-names></name><xref ref-type="aff" rid="A13">m</xref></contrib><contrib contrib-type="author"><name><surname>Pfeilschifter</surname><given-names>Johannes</given-names></name><xref ref-type="aff" rid="A14">n</xref></contrib><contrib contrib-type="author"><name><surname>Roux</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="A15">o</xref></contrib><contrib contrib-type="author"><name><surname>Saag</surname><given-names>Kenneth G.</given-names></name><xref ref-type="aff" rid="A16">p</xref></contrib><contrib contrib-type="author"><name><surname>Sambrook</surname><given-names>Philip</given-names></name><xref ref-type="aff" rid="A17">q</xref></contrib><contrib contrib-type="author"><name><surname>Silverman</surname><given-names>Stuart</given-names></name><xref ref-type="aff" rid="A18">r</xref></contrib><contrib contrib-type="author"><name><surname>Siris</surname><given-names>Ethel S.</given-names></name><xref ref-type="aff" rid="A19">s</xref></contrib><contrib contrib-type="author"><name><surname>Watts</surname><given-names>Nelson B.</given-names></name><xref ref-type="aff" rid="A20">t</xref></contrib><contrib contrib-type="author"><name><surname>Nika</surname><given-names>Grigor</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Gehlbach</surname><given-names>Stephen H.</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib></contrib-group><aff id="A1"><label>a</label> Hospital del Mar-IMIM, Autonomous University of Barcelona and RETICEF, Instituto Carlos III, Barcelona, Spain</aff><aff id="A2"><label>b</label> Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA</aff><aff id="A3"><label>c</label> St Joseph's Hospital, McMaster University, Hamilton, ON, Canada</aff><aff id="A4"><label>d</label> Department of Rheumatology, University of Verona, Ospedale, Verona, Valeggio, Italy</aff><aff id="A5"><label>e</label> Leuven University Centre for Metabolic Bone Diseases, Division of Geriatric Medicine, Katholieke Universiteit Leuven, Leuven, Belgium</aff><aff id="A6"><label>f</label> INSERM Research Unit 831, Université de Lyon, Department of Orthopedics and Rheumatology, Hôpital E Herriot, Lyon, France</aff><aff id="A7"><label>g</label> University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK</aff><aff id="A8"><label>h</label> MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital and Norman Collisson Chair of Musculoskeletal Sciences, University of Oxford, Oxford, UK</aff><aff id="A9"><label>i</label> Hôpital Edouard Herriot, Lyon, France</aff><aff id="A10"><label>j</label> University of Pittsburgh, PA, USA</aff><aff id="A11"><label>k</label> Fred Hutchinson Cancer Research Center, Seattle, WA, USA</aff><aff id="A12"><label>l</label> Regional Bone Center, Helen Hayes Hospital, West Haverstraw, NY, USA</aff><aff id="A13"><label>m</label> Department of Endocrinology, VU University Medical Center, Amsterdam, Netherlands</aff><aff id="A14"><label>n</label> Alfried Krupp Krankenhaus, Department of Internal Medicine III, Essen, Germany</aff><aff id="A15"><label>o</label> Paris Descartes University, Cochin Hospital, Paris, France</aff><aff id="A16"><label>p</label> University of Alabama-Birmingham, Division of Clinical Immunology and Rheumatology, Birmingham, AL, USA</aff><aff id="A17"><label>q</label> University of Sydney-Royal North Shore Hospital, St. Leonards, Sydney, NSW, Australia</aff><aff id="A18"><label>r</label> Cedars-Sinai Medical Center, Los Angeles, CA, USA</aff><aff id="A19"><label>s</label> Columbia University Medical Center, New York, NY, USA</aff><aff id="A20"><label>t</label> Bone Health and Osteoporosis Center, University of Cincinnati, Cincinnati, OH, USA</aff><author-notes><corresp id="CR1"><label>*</label><bold>Corresponding author.</bold> Hospital del Mar-IMIM-Autonomous University of Barcelona, Po Maritim, 25-29, Barcelona, 08003 Spain. Tel: <>. <email>Adiez@hospitaldelmar.cat</email> (A. Díez-Pérez).</corresp> </author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>5</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>14</day><month>5</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>08</day><month>6</month><year>2016</year></pub-date><volume>49</volume><issue>3</issue><fpage>493</fpage><lpage>498</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.bone.2011.05.007</pmc-comment>
<abstract><sec id="S1"><title>Purpose</title><p id="P1">To determine if important geographic differences exist in treatment rates for osteoporosis and whether this variation can be explained by regional variation in risk factors.</p></sec><sec id="S2"><title>Methods</title><p id="P2">The Global Longitudinal Study of Osteoporosis in Women is an observational study of women ≥55 years sampled from primary care practices in 10 countries. Self-administered questionnaires were used to collect data on patient characteristics, risk factors for fracture, previous fractures, anti-osteoporosis medication, and health status.</p></sec><sec id="S3"><title>Results</title><p id="P3">Among 58,009 women, current anti-osteoporosis medication use was lowest in Northern Europe (16%) and highest in USA and Australia (32%). Between 48% (USA, Southern Europe) and 68% (Northern Europe) of women aged ≥65 years with a history of spine or hip fracture since age 45 were untreated. Among women with osteoporosis, the percentage of treated cases was lowest in Europe (45– 52% versus 62–65% elsewhere). Women with osteopenia and no other risk factors were treated with anti-osteoporosis medication most frequently in USA (31%) and Canada (31%), and least frequently in Southern Europe (12%), Northern Europe (13%), and Australia (16%). After adjusting for risk factors, US women were threefold as likely to be treated with anti-osteoporosis medication as Northern European women (odds ratio 2.8; 95% confidence interval 2.5–3.1) and 1.5 times as likely to be treated as Southern European women (1.5, 1.4–1.6). Up to half of women reporting previous hip or spine fracture did not receive treatment.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The likelihood of being treated for osteoporosis differed between regions, and cannot be explained by variation in risk factors. Many women at risk of fracture do not receive prophylaxis.</p></sec></abstract><kwd-group><kwd>Fracture</kwd><kwd>Regional variation</kwd><kwd>Women</kwd><kwd>Risk factor</kwd><kwd>Preventive treatment</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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