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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of New Genetic Susceptibility Loci for Breast Cancer
Through Consideration of Gene-Environment Interactions</title><author><name sortKey="Schoeps, Anja" sort="Schoeps, Anja" uniqKey="Schoeps A" first="Anja" last="Schoeps">Anja Schoeps</name><affiliation><nlm:aff id="A1">Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Institute of Public Health, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A1">Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Seibold, Petra" sort="Seibold, Petra" uniqKey="Seibold P" first="Petra" last="Seibold">Petra Seibold</name><affiliation><nlm:aff id="A1">Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A3">Department of Oncology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A4">Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A5">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="A7">Department of Genetics and Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene" sort="Andrulis, Irene" uniqKey="Andrulis I" first="Irene" last="Andrulis">Irene Andrulis</name><affiliation><nlm:aff id="A8">Department of Molecular Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A9">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A10">German Cancer Consortium, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Behrens, Sabine" sort="Behrens, Sabine" uniqKey="Behrens S" first="Sabine" last="Behrens">Sabine Behrens</name><affiliation><nlm:aff id="A1">Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Orr, Nicholas" sort="Orr, Nicholas" uniqKey="Orr N" first="Nicholas" last="Orr">Nicholas Orr</name><affiliation><nlm:aff id="A11">Department of Breast Cancer Research, Institute of Cancer Research, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation><nlm:aff id="A6">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="A12">Department of Human Genetics, Genome Institute of Singapore, Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="A12">Department of Human Genetics, Genome Institute of Singapore, Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Cramp, Helen" sort="Cramp, Helen" uniqKey="Cramp H" first="Helen" last="Cramp">Helen Cramp</name><affiliation><nlm:aff id="A13">Department of Oncology, Institute for Cancer Studies, University of Sheffield, Sheffield, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Connley, Dan" sort="Connley, Dan" uniqKey="Connley D" first="Dan" last="Connley">Dan Connley</name><affiliation><nlm:aff id="A13">Department of Oncology, Institute for Cancer Studies, University of Sheffield, Sheffield, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A14">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="A14">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A15">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="A16">Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:aff id="A15">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia" sort="Knight, Julia" uniqKey="Knight J" first="Julia" last="Knight">Julia Knight</name><affiliation><nlm:aff id="A17">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Prosserman Centre for Health Research, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A18">Prosserman Centre for Health Research, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna M" sort="Mulligan, Anna M" uniqKey="Mulligan A" first="Anna M." last="Mulligan">Anna M. Mulligan</name><affiliation><nlm:aff id="A19">Laboratory Medicine Program, University Health Network, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="A20">Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Department of Molecular Medicine, Faculty of Medicine, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A22">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="A22">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet" sort="Olson, Janet" uniqKey="Olson J" first="Janet" last="Olson">Janet Olson</name><affiliation><nlm:aff id="A24">Department of Health Sciences Research, Mayo Clinic, Minnesota, United States of America</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="A24">Department of Health Sciences Research, Mayo Clinic, Minnesota, United States of America</nlm:aff></affiliation></author><author><name sortKey="Purrington, Kristen" sort="Purrington, Kristen" uniqKey="Purrington K" first="Kristen" last="Purrington">Kristen Purrington</name><affiliation><nlm:aff id="A24">Department of Health Sciences Research, Mayo Clinic, Minnesota, United States of America</nlm:aff></affiliation></author><author><name sortKey="Moisse, Matthieu" sort="Moisse, Matthieu" uniqKey="Moisse M" first="Matthieu" last="Moisse">Matthieu Moisse</name><affiliation><nlm:aff id="A25">Vesalius Research Center (VRC), VIB, Flanders, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Laboratory of Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name><affiliation><nlm:aff id="A27">Department of Multidisciplinary Breast Cancer, University Hospital Gasthuisberg, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name><affiliation><nlm:aff id="A27">Department of Multidisciplinary Breast Cancer, University Hospital Gasthuisberg, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda" sort="Spurdle, Amanda" uniqKey="Spurdle A" first="Amanda" last="Spurdle">Amanda Spurdle</name><affiliation><nlm:aff id="A28">Department of Molecular Cancer Epidemiology, Queensland Institute of Medical Research, Brisbane Australia</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A29">Pathology Department, University of Kuopio, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="A29">Pathology Department, University of Kuopio, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="A30">Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A31">Division of Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation><nlm:aff id="A32">Department of Internal Medicine, Evangelische Kliniken Bonn GmbH, Johanniter Krankenhaus, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Dieffenbach, Aida K" sort="Dieffenbach, Aida K" uniqKey="Dieffenbach A" first="Aida K." last="Dieffenbach">Aida K. Dieffenbach</name><affiliation><nlm:aff id="A9">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A10">German Cancer Consortium, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A9">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="A33">Saarland Cancer Registry, Saarbrücken, Germany</nlm:aff></affiliation></author><author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Núria" last="Malats">Núria Malats</name><affiliation><nlm:aff id="A4">Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Arias Perez, Josei" sort="Arias Perez, Josei" uniqKey="Arias Perez J" first="Joséi." last="Arias Perez">Joséi. Arias Perez</name><affiliation><nlm:aff id="A34">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><nlm:aff id="A35">Human Genetics Group, Spanish National Cancer Reserach Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="A36">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="A5">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Théresè" last="Truong">Théresè Truong</name><affiliation><nlm:aff id="A37">Unité Mixte de Recherche Scientifique (UMRS) 1018, University Paris-Sud, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A38">INSERM (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Cordina Duverger, Emilie" sort="Cordina Duverger, Emilie" uniqKey="Cordina Duverger E" first="Emilie" last="Cordina-Duverger">Emilie Cordina-Duverger</name><affiliation><nlm:aff id="A37">Unité Mixte de Recherche Scientifique (UMRS) 1018, University Paris-Sud, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A38">INSERM (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation><nlm:aff id="A37">Unité Mixte de Recherche Scientifique (UMRS) 1018, University Paris-Sud, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A38">INSERM (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Silva, Isabel Dos Santos" sort="Silva, Isabel Dos Santos" uniqKey="Silva I" first="Isabel Dos Santos" last="Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="A39">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A40">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="A40">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="H Berle, Lothar" sort="H Berle, Lothar" uniqKey="H Berle L" first="Lothar" last="H Berle">Lothar H Berle</name><affiliation><nlm:aff id="A41">Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A41">Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="A42">Institute of Human Genetics, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Braaf, Linde" sort="Braaf, Linde" uniqKey="Braaf L" first="Linde" last="Braaf">Linde Braaf</name><affiliation><nlm:aff id="A43">Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A44">Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Atsma, Femke" sort="Atsma, Femke" uniqKey="Atsma F" first="Femke" last="Atsma">Femke Atsma</name><affiliation><nlm:aff id="A45">Department of Donor Studies, Sanquin Nijmegen, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Den Broek, Alexandra J" sort="Van Den Broek, Alexandra J" uniqKey="Van Den Broek A" first="Alexandra J." last="Van Den Broek">Alexandra J. Van Den Broek</name><affiliation><nlm:aff id="A44">Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation><nlm:aff id="A46">Department of Analytic Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F." last="Schmidt">Daniel F. Schmidt</name><affiliation><nlm:aff id="A23">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A47">Department of Pathology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A13">Department of Oncology, Institute for Cancer Studies, University of Sheffield, Sheffield, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A20">Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Department of Molecular Medicine, Faculty of Medicine, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A22">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A25">Vesalius Research Center (VRC), VIB, Flanders, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Laboratory of Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A48">Department of Pathology and Forensic Medicine, Kuopio University Hospital, University of Kuopio, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A49">Dr. Margarete Fischer-Bosch Institute of Clinical Pharamcology, Stuttgart, Germany</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="A37">Unité Mixte de Recherche Scientifique (UMRS) 1018, University Paris-Sud, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A38">INSERM (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="A39">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A41">Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, United States</nlm:aff></affiliation></author><author><name sortKey="Hopper, John" sort="Hopper, John" uniqKey="Hopper J" first="John" last="Hopper">John Hopper</name><affiliation><nlm:aff id="A51">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A52">Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus" sort="Couch, Fergus" uniqKey="Couch F" first="Fergus" last="Couch">Fergus Couch</name><affiliation><nlm:aff id="A54">Department of Experimental Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A28">Department of Molecular Cancer Epidemiology, Queensland Institute of Medical Research, Brisbane Australia</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="A55">Department of Oncology and Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation><nlm:aff id="A56">Division of Genetics and Epidemiology, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A43">Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A44">Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A14">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A57">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24248812</idno><idno type="pmc">3995140</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995140</idno><idno type="RBID">PMC:3995140</idno><idno type="doi">10.1002/gepi.21771</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002026</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002026</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of New Genetic Susceptibility Loci for Breast Cancer
Through Consideration of Gene-Environment Interactions</title><author><name sortKey="Schoeps, Anja" sort="Schoeps, Anja" uniqKey="Schoeps A" first="Anja" last="Schoeps">Anja Schoeps</name><affiliation><nlm:aff id="A1">Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Institute of Public Health, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A1">Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Seibold, Petra" sort="Seibold, Petra" uniqKey="Seibold P" first="Petra" last="Seibold">Petra Seibold</name><affiliation><nlm:aff id="A1">Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A3">Department of Oncology, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A4">Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A5">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="A7">Department of Genetics and Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene" sort="Andrulis, Irene" uniqKey="Andrulis I" first="Irene" last="Andrulis">Irene Andrulis</name><affiliation><nlm:aff id="A8">Department of Molecular Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A9">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A10">German Cancer Consortium, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Behrens, Sabine" sort="Behrens, Sabine" uniqKey="Behrens S" first="Sabine" last="Behrens">Sabine Behrens</name><affiliation><nlm:aff id="A1">Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Orr, Nicholas" sort="Orr, Nicholas" uniqKey="Orr N" first="Nicholas" last="Orr">Nicholas Orr</name><affiliation><nlm:aff id="A11">Department of Breast Cancer Research, Institute of Cancer Research, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation><nlm:aff id="A6">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="A12">Department of Human Genetics, Genome Institute of Singapore, Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="A12">Department of Human Genetics, Genome Institute of Singapore, Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Cramp, Helen" sort="Cramp, Helen" uniqKey="Cramp H" first="Helen" last="Cramp">Helen Cramp</name><affiliation><nlm:aff id="A13">Department of Oncology, Institute for Cancer Studies, University of Sheffield, Sheffield, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Connley, Dan" sort="Connley, Dan" uniqKey="Connley D" first="Dan" last="Connley">Dan Connley</name><affiliation><nlm:aff id="A13">Department of Oncology, Institute for Cancer Studies, University of Sheffield, Sheffield, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A14">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><affiliation><nlm:aff id="A14">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A15">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</nlm:aff></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation><nlm:aff id="A16">Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:aff id="A15">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia" sort="Knight, Julia" uniqKey="Knight J" first="Julia" last="Knight">Julia Knight</name><affiliation><nlm:aff id="A17">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Prosserman Centre for Health Research, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A18">Prosserman Centre for Health Research, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna M" sort="Mulligan, Anna M" uniqKey="Mulligan A" first="Anna M." last="Mulligan">Anna M. Mulligan</name><affiliation><nlm:aff id="A19">Laboratory Medicine Program, University Health Network, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="A20">Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Department of Molecular Medicine, Faculty of Medicine, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A22">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="A22">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet" sort="Olson, Janet" uniqKey="Olson J" first="Janet" last="Olson">Janet Olson</name><affiliation><nlm:aff id="A24">Department of Health Sciences Research, Mayo Clinic, Minnesota, United States of America</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="A24">Department of Health Sciences Research, Mayo Clinic, Minnesota, United States of America</nlm:aff></affiliation></author><author><name sortKey="Purrington, Kristen" sort="Purrington, Kristen" uniqKey="Purrington K" first="Kristen" last="Purrington">Kristen Purrington</name><affiliation><nlm:aff id="A24">Department of Health Sciences Research, Mayo Clinic, Minnesota, United States of America</nlm:aff></affiliation></author><author><name sortKey="Moisse, Matthieu" sort="Moisse, Matthieu" uniqKey="Moisse M" first="Matthieu" last="Moisse">Matthieu Moisse</name><affiliation><nlm:aff id="A25">Vesalius Research Center (VRC), VIB, Flanders, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Laboratory of Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name><affiliation><nlm:aff id="A27">Department of Multidisciplinary Breast Cancer, University Hospital Gasthuisberg, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name><affiliation><nlm:aff id="A27">Department of Multidisciplinary Breast Cancer, University Hospital Gasthuisberg, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda" sort="Spurdle, Amanda" uniqKey="Spurdle A" first="Amanda" last="Spurdle">Amanda Spurdle</name><affiliation><nlm:aff id="A28">Department of Molecular Cancer Epidemiology, Queensland Institute of Medical Research, Brisbane Australia</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A29">Pathology Department, University of Kuopio, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="A29">Pathology Department, University of Kuopio, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="A30">Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A31">Division of Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><affiliation><nlm:aff id="A32">Department of Internal Medicine, Evangelische Kliniken Bonn GmbH, Johanniter Krankenhaus, Bonn, Germany</nlm:aff></affiliation></author><author><name sortKey="Dieffenbach, Aida K" sort="Dieffenbach, Aida K" uniqKey="Dieffenbach A" first="Aida K." last="Dieffenbach">Aida K. Dieffenbach</name><affiliation><nlm:aff id="A9">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A10">German Cancer Consortium, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A9">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><affiliation><nlm:aff id="A33">Saarland Cancer Registry, Saarbrücken, Germany</nlm:aff></affiliation></author><author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Núria" last="Malats">Núria Malats</name><affiliation><nlm:aff id="A4">Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Arias Perez, Josei" sort="Arias Perez, Josei" uniqKey="Arias Perez J" first="Joséi." last="Arias Perez">Joséi. Arias Perez</name><affiliation><nlm:aff id="A34">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><nlm:aff id="A35">Human Genetics Group, Spanish National Cancer Reserach Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="A36">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="A5">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Théresè" last="Truong">Théresè Truong</name><affiliation><nlm:aff id="A37">Unité Mixte de Recherche Scientifique (UMRS) 1018, University Paris-Sud, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A38">INSERM (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Cordina Duverger, Emilie" sort="Cordina Duverger, Emilie" uniqKey="Cordina Duverger E" first="Emilie" last="Cordina-Duverger">Emilie Cordina-Duverger</name><affiliation><nlm:aff id="A37">Unité Mixte de Recherche Scientifique (UMRS) 1018, University Paris-Sud, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A38">INSERM (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><affiliation><nlm:aff id="A37">Unité Mixte de Recherche Scientifique (UMRS) 1018, University Paris-Sud, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A38">INSERM (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Silva, Isabel Dos Santos" sort="Silva, Isabel Dos Santos" uniqKey="Silva I" first="Isabel Dos Santos" last="Silva">Isabel Dos Santos Silva</name><affiliation><nlm:aff id="A39">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A40">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="A40">Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="H Berle, Lothar" sort="H Berle, Lothar" uniqKey="H Berle L" first="Lothar" last="H Berle">Lothar H Berle</name><affiliation><nlm:aff id="A41">Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A41">Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="A42">Institute of Human Genetics, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Braaf, Linde" sort="Braaf, Linde" uniqKey="Braaf L" first="Linde" last="Braaf">Linde Braaf</name><affiliation><nlm:aff id="A43">Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A44">Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Atsma, Femke" sort="Atsma, Femke" uniqKey="Atsma F" first="Femke" last="Atsma">Femke Atsma</name><affiliation><nlm:aff id="A45">Department of Donor Studies, Sanquin Nijmegen, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Den Broek, Alexandra J" sort="Van Den Broek, Alexandra J" uniqKey="Van Den Broek A" first="Alexandra J." last="Van Den Broek">Alexandra J. Van Den Broek</name><affiliation><nlm:aff id="A44">Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation><nlm:aff id="A46">Department of Analytic Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F." last="Schmidt">Daniel F. Schmidt</name><affiliation><nlm:aff id="A23">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A47">Department of Pathology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A13">Department of Oncology, Institute for Cancer Studies, University of Sheffield, Sheffield, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A20">Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Department of Molecular Medicine, Faculty of Medicine, Quebec, Canada</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A22">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A25">Vesalius Research Center (VRC), VIB, Flanders, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Laboratory of Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A48">Department of Pathology and Forensic Medicine, Kuopio University Hospital, University of Kuopio, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A49">Dr. Margarete Fischer-Bosch Institute of Clinical Pharamcology, Stuttgart, Germany</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="A37">Unité Mixte de Recherche Scientifique (UMRS) 1018, University Paris-Sud, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A38">INSERM (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="A39">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A41">Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, United States</nlm:aff></affiliation></author><author><name sortKey="Hopper, John" sort="Hopper, John" uniqKey="Hopper J" first="John" last="Hopper">John Hopper</name><affiliation><nlm:aff id="A51">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A52">Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus" sort="Couch, Fergus" uniqKey="Couch F" first="Fergus" last="Couch">Fergus Couch</name><affiliation><nlm:aff id="A54">Department of Experimental Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A28">Department of Molecular Cancer Epidemiology, Queensland Institute of Medical Research, Brisbane Australia</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="A55">Department of Oncology and Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation><nlm:aff id="A56">Division of Genetics and Epidemiology, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A43">Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A44">Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A14">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A57">Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name></author></analytic><series><title level="j">Genetic epidemiology</title><idno type="ISSN">0741-0395</idno><idno type="eISSN">1098-2272</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Genes that alter disease risk only in combination with certain
environmental exposures may not be detected in genetic association analysis. By
using methods accounting for gene-environment (G × E) interaction, we
aimed to identify novel genetic loci associated with breast cancer risk. Up to
34,475 cases and 34,786 controls of European ancestry from up to 23 studies in
the Breast Cancer Association Consortium were included. Overall, 71,527 single
nucleotide polymorphisms (SNPs), enriched for association with breast cancer,
were tested for interaction with 10 environmental risk factors using three
recently proposed hybrid methods and a joint test of association and
interaction. Analyses were adjusted for age, study, population stratification,
and confounding factors as applicable. Three SNPs in two independent loci showed
statistically significant association: SNPs rs10483028 and rs2242714 in perfect
linkage disequilibrium on chromosome 21 and rs12197388 in ARID1B on chromosome
6. While rs12197388 was identified using the joint test with parity and with age
at menarche (<italic>P</italic>-values = 3 × 10<sup>−07</sup>),
the variants on chromosome 21 q22.12, which showed interaction with adult body
mass index (BMI) in 8,891 postmenopausal women, were identified by all methods
applied. SNP rs10483028 was associated with breast cancer in women with a BMI
below 25 kg/m<sup>2</sup> (OR = 1.26, 95% CI 1.15–1.38) but not in women
with a BMI of 30 kg/m<sup>2</sup> or higher (OR = 0.89, 95% CI 0.72–1.11,
<italic>P</italic> for interaction = 3.2 × 10<sup>−05</sup>).
Our findings confirm comparable power of the recent methods for detecting G
× E interaction and the utility of using G × E interaction
analyses to identify new susceptibility loci.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8411723</journal-id><journal-id journal-id-type="pubmed-jr-id">3864</journal-id><journal-id journal-id-type="nlm-ta">Genet Epidemiol</journal-id><journal-id journal-id-type="iso-abbrev">Genet. Epidemiol.</journal-id><journal-title-group><journal-title>Genetic epidemiology</journal-title></journal-title-group><issn pub-type="ppub">0741-0395</issn><issn pub-type="epub">1098-2272</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24248812</article-id><article-id pub-id-type="pmc">3995140</article-id><article-id pub-id-type="doi">10.1002/gepi.21771</article-id><article-id pub-id-type="manuscript">NIHMS567528</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Identification of New Genetic Susceptibility Loci for Breast Cancer
Through Consideration of Gene-Environment Interactions</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Schoeps</surname><given-names>Anja</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FN2">†</xref></contrib><contrib contrib-type="author"><name><surname>Rudolph</surname><given-names>Anja</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="author-notes" rid="FN2">†</xref></contrib><contrib contrib-type="author"><name><surname>Seibold</surname><given-names>Petra</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Milne</surname><given-names>Roger L.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Bojesen</surname><given-names>Stig E.</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Swerdlow</surname><given-names>Anthony</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Andrulis</surname><given-names>Irene</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Brenner</surname><given-names>Hermann</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Behrens</surname><given-names>Sabine</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Orr</surname><given-names>Nicholas</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Ashworth</surname><given-names>Alan</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Jingmei</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Cramp</surname><given-names>Helen</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Connley</surname><given-names>Dan</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Czene</surname><given-names>Kamila</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Darabi</surname><given-names>Hatef</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Chanock</surname><given-names>Stephen J.</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Lissowska</surname><given-names>Jolanta</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Figueroa</surname><given-names>Jonine D.</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Knight</surname><given-names>Julia</given-names></name><xref ref-type="aff" rid="A17">17</xref><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Glendon</surname><given-names>Gord</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Mulligan</surname><given-names>Anna M.</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Dumont</surname><given-names>Martine</given-names></name><xref ref-type="aff" rid="A20">20</xref><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Severi</surname><given-names>Gianluca</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Baglietto</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="A22">22</xref><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Olson</surname><given-names>Janet</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Vachon</surname><given-names>Celine</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Purrington</surname><given-names>Kristen</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Moisse</surname><given-names>Matthieu</given-names></name><xref ref-type="aff" rid="A25">25</xref><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Neven</surname><given-names>Patrick</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Wildiers</surname><given-names>Hans</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Spurdle</surname><given-names>Amanda</given-names></name><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Kosma</surname><given-names>Veli-Matti</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Kataja</surname><given-names>Vesa</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Hartikainen</surname><given-names>Jaana M.</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Ko</surname><given-names>Yon-Dschun</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Dieffenbach</surname><given-names>Aida K.</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Arndt</surname><given-names>Volker</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Stegmaier</surname><given-names>Christa</given-names></name><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Malats</surname><given-names>Núria</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Arias Perez</surname><given-names>JoséI.</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Benítez</surname><given-names>Javier</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Flyger</surname><given-names>Henrik</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Nordestgaard</surname><given-names>Børge G.</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Truong</surname><given-names>Théresè</given-names></name><xref ref-type="aff" rid="A37">37</xref><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Cordina-Duverger</surname><given-names>Emilie</given-names></name><xref ref-type="aff" rid="A37">37</xref><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Menegaux</surname><given-names>Florence</given-names></name><xref ref-type="aff" rid="A37">37</xref><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Silva</surname><given-names>Isabel dos Santos</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Fletcher</surname><given-names>Olivia</given-names></name><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Nichola</given-names></name><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Häberle</surname><given-names>Lothar</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Beckmann</surname><given-names>Matthias W.</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Ekici</surname><given-names>Arif B.</given-names></name><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Braaf</surname><given-names>Linde</given-names></name><xref ref-type="aff" rid="A43">43</xref><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Atsma</surname><given-names>Femke</given-names></name><xref ref-type="aff" rid="A45">45</xref></contrib><contrib contrib-type="author"><name><surname>van den Broek</surname><given-names>Alexandra J.</given-names></name><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Makalic</surname><given-names>Enes</given-names></name><xref ref-type="aff" rid="A46">46</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Daniel F.</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Southey</surname><given-names>Melissa C.</given-names></name><xref ref-type="aff" rid="A47">47</xref></contrib><contrib contrib-type="author"><name><surname>Cox</surname><given-names>Angela</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Simard</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="A20">20</xref><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham G.</given-names></name><xref ref-type="aff" rid="A22">22</xref><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Lambrechts</surname><given-names>Diether</given-names></name><xref ref-type="aff" rid="A25">25</xref><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Mannermaa</surname><given-names>Arto</given-names></name><xref ref-type="aff" rid="A48">48</xref></contrib><contrib contrib-type="author"><name><surname>Brauch</surname><given-names>Hiltrud</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Guénel</surname><given-names>Pascal</given-names></name><xref ref-type="aff" rid="A37">37</xref><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Peto</surname><given-names>Julian</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Fasching</surname><given-names>Peter A.</given-names></name><xref ref-type="aff" rid="A41">41</xref><xref ref-type="aff" rid="A50">50</xref></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John</given-names></name><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Flesch-Janys</surname><given-names>Dieter</given-names></name><xref ref-type="aff" rid="A52">52</xref><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus</given-names></name><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D. P.</given-names></name><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><name><surname>Garcia-Closas</surname><given-names>Montserrat</given-names></name><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Marjanka K.</given-names></name><xref ref-type="aff" rid="A43">43</xref><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><xref ref-type="corresp" rid="CR1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A2"><label>2</label>Institute of Public Health, University of Heidelberg, Heidelberg, Germany</aff><aff id="A3"><label>3</label>Department of Oncology, University of Cambridge, Cambridge, United Kingdom</aff><aff id="A4"><label>4</label>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</aff><aff id="A5"><label>5</label>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A6"><label>6</label>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A7"><label>7</label>Department of Genetics and Epidemiology, Institute of Cancer Research, Sutton, United Kingdom</aff><aff id="A8"><label>8</label>Department of Molecular Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</aff><aff id="A9"><label>9</label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A10"><label>10</label>German Cancer Consortium, Heidelberg, Germany</aff><aff id="A11"><label>11</label>Department of Breast Cancer Research, Institute of Cancer Research, London, United Kingdom</aff><aff id="A12"><label>12</label>Department of Human Genetics, Genome Institute of Singapore, Singapore, Singapore</aff><aff id="A13"><label>13</label>Department of Oncology, Institute for Cancer Studies, University of Sheffield, Sheffield, United Kingdom</aff><aff id="A14"><label>14</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A15"><label>15</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</aff><aff id="A16"><label>16</label>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</aff><aff id="A17"><label>17</label>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</aff><aff id="A18"><label>18</label>Prosserman Centre for Health Research, Toronto, Canada</aff><aff id="A19"><label>19</label>Laboratory Medicine Program, University Health Network, Toronto, Canada</aff><aff id="A20"><label>20</label>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec, Canada</aff><aff id="A21"><label>21</label>Department of Molecular Medicine, Faculty of Medicine, Quebec, Canada</aff><aff id="A22"><label>22</label>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</aff><aff id="A23"><label>23</label>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia</aff><aff id="A24"><label>24</label>Department of Health Sciences Research, Mayo Clinic, Minnesota, United States of America</aff><aff id="A25"><label>25</label>Vesalius Research Center (VRC), VIB, Flanders, Belgium</aff><aff id="A26"><label>26</label>Laboratory of Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</aff><aff id="A27"><label>27</label>Department of Multidisciplinary Breast Cancer, University Hospital Gasthuisberg, Leuven, Belgium</aff><aff id="A28"><label>28</label>Department of Molecular Cancer Epidemiology, Queensland Institute of Medical Research, Brisbane Australia</aff><aff id="A29"><label>29</label>Pathology Department, University of Kuopio, Kuopio, Finland</aff><aff id="A30"><label>30</label>Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland</aff><aff id="A31"><label>31</label>Division of Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A32"><label>32</label>Department of Internal Medicine, Evangelische Kliniken Bonn GmbH, Johanniter Krankenhaus, Bonn, Germany</aff><aff id="A33"><label>33</label>Saarland Cancer Registry, Saarbrücken, Germany</aff><aff id="A34"><label>34</label>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</aff><aff id="A35"><label>35</label>Human Genetics Group, Spanish National Cancer Reserach Centre (CNIO), Madrid, Spain</aff><aff id="A36"><label>36</label>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A37"><label>37</label>Unité Mixte de Recherche Scientifique (UMRS) 1018, University Paris-Sud, Villejuif, France</aff><aff id="A38"><label>38</label>INSERM (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France</aff><aff id="A39"><label>39</label>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom</aff><aff id="A40"><label>40</label>Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom</aff><aff id="A41"><label>41</label>Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</aff><aff id="A42"><label>42</label>Institute of Human Genetics, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</aff><aff id="A43"><label>43</label>Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands</aff><aff id="A44"><label>44</label>Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</aff><aff id="A45"><label>45</label>Department of Donor Studies, Sanquin Nijmegen, Nijmegen, The Netherlands</aff><aff id="A46"><label>46</label>Department of Analytic Epidemiology, University of Melbourne, Melbourne, Australia</aff><aff id="A47"><label>47</label>Department of Pathology, University of Melbourne, Melbourne, Australia</aff><aff id="A48"><label>48</label>Department of Pathology and Forensic Medicine, Kuopio University Hospital, University of Kuopio, Kuopio, Finland</aff><aff id="A49"><label>49</label>Dr. Margarete Fischer-Bosch Institute of Clinical Pharamcology, Stuttgart, Germany</aff><aff id="A50"><label>50</label>Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, United States</aff><aff id="A51"><label>51</label>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Victoria, Australia</aff><aff id="A52"><label>52</label>Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany</aff><aff id="A53"><label>53</label>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</aff><aff id="A54"><label>54</label>Department of Experimental Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</aff><aff id="A55"><label>55</label>Department of Oncology and Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</aff><aff id="A56"><label>56</label>Division of Genetics and Epidemiology, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom</aff><aff id="A57"><label>57</label>Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</aff><author-notes><corresp id="CR1"><label>*</label>Correspondence to: Jenny Chang-Claude, Department
of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer
Feld 581, 69120 Heidelberg, Germany.
<email>j.chang-claude@dkfz.de</email></corresp><fn fn-type="equal" id="FN2"><label>†</label><p id="P1">These authors contributed equally to this paper.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>27</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>18</day><month>11</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>22</day><month>4</month><year>2014</year></pub-date><volume>38</volume><issue>1</issue><fpage>84</fpage><lpage>93</lpage><pmc-comment>elocation-id from pubmed: 10.1002/gepi.21771</pmc-comment>
<permissions><copyright-statement>© 2013 Wiley Periodicals, Inc</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><p id="P2">Genes that alter disease risk only in combination with certain
environmental exposures may not be detected in genetic association analysis. By
using methods accounting for gene-environment (G × E) interaction, we
aimed to identify novel genetic loci associated with breast cancer risk. Up to
34,475 cases and 34,786 controls of European ancestry from up to 23 studies in
the Breast Cancer Association Consortium were included. Overall, 71,527 single
nucleotide polymorphisms (SNPs), enriched for association with breast cancer,
were tested for interaction with 10 environmental risk factors using three
recently proposed hybrid methods and a joint test of association and
interaction. Analyses were adjusted for age, study, population stratification,
and confounding factors as applicable. Three SNPs in two independent loci showed
statistically significant association: SNPs rs10483028 and rs2242714 in perfect
linkage disequilibrium on chromosome 21 and rs12197388 in ARID1B on chromosome
6. While rs12197388 was identified using the joint test with parity and with age
at menarche (<italic>P</italic>-values = 3 × 10<sup>−07</sup>),
the variants on chromosome 21 q22.12, which showed interaction with adult body
mass index (BMI) in 8,891 postmenopausal women, were identified by all methods
applied. SNP rs10483028 was associated with breast cancer in women with a BMI
below 25 kg/m<sup>2</sup> (OR = 1.26, 95% CI 1.15–1.38) but not in women
with a BMI of 30 kg/m<sup>2</sup> or higher (OR = 0.89, 95% CI 0.72–1.11,
<italic>P</italic> for interaction = 3.2 × 10<sup>−05</sup>).
Our findings confirm comparable power of the recent methods for detecting G
× E interaction and the utility of using G × E interaction
analyses to identify new susceptibility loci.</p></abstract><kwd-group><kwd>breast cancer risk</kwd><kwd>gene-environment interaction</kwd><kwd>polymorphisms</kwd><kwd>body mass index</kwd><kwd>case-control study</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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