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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects</title><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><affiliation><nlm:aff id="A1">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Spears, Melissa" sort="Spears, Melissa" uniqKey="Spears M" first="Melissa" last="Spears">Melissa Spears</name><affiliation><nlm:aff id="A1">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Boustred, Chris" sort="Boustred, Chris" uniqKey="Boustred C" first="Chris" last="Boustred">Chris Boustred</name><affiliation><nlm:aff id="A1">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="May, Margaret" sort="May, Margaret" uniqKey="May M" first="Margaret" last="May">Margaret May</name><affiliation><nlm:aff id="A1">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Anderson, Simon G" sort="Anderson, Simon G" uniqKey="Anderson S" first="Simon G" last="Anderson">Simon G. Anderson</name><affiliation><nlm:aff id="A2">Manchester Medical School, Manchester, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Benjamin, Emelia J" sort="Benjamin, Emelia J" uniqKey="Benjamin E" first="Emelia J." last="Benjamin">Emelia J. Benjamin</name><affiliation><nlm:aff id="A3">National Heart Lung and Blood Institute and Boston University’s Framingham Heart Study, Cardiology Section, Department of Medicine, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Boutouyrie, Pierre" sort="Boutouyrie, Pierre" uniqKey="Boutouyrie P" first="Pierre" last="Boutouyrie">Pierre Boutouyrie</name><affiliation><nlm:aff id="A4">INSERM U 970, Paris-Descartes University, Hopital Europeen Geroges Pompidou, Assistance Publique Hopitaux de Paris, France</nlm:aff></affiliation></author><author><name sortKey="Cameron, James" sort="Cameron, James" uniqKey="Cameron J" first="James" last="Cameron">James Cameron</name><affiliation><nlm:aff id="A5">Monash Cardiovascular Research Centre, MonashHEART and Monash University Department of Medicine (MMC), Melbourne, Australia, Australia</nlm:aff></affiliation></author><author><name sortKey="Chen, Chen Huan" sort="Chen, Chen Huan" uniqKey="Chen C" first="Chen-Huan" last="Chen">Chen-Huan Chen</name><affiliation><nlm:aff id="A6">School of Medicine, National Yang-Ming University, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Cruickshank, J Kennedy" sort="Cruickshank, J Kennedy" uniqKey="Cruickshank J" first="J Kennedy" last="Cruickshank">J Kennedy Cruickshank</name><affiliation><nlm:aff id="A7">King’s College & King’s Health Partners, St. Thomas’ & Guy’s Hospital, London</nlm:aff></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation><nlm:aff id="A8">Centre for Population Studies, National Heart, Lung and Blood Institute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Lakatta, Edward G" sort="Lakatta, Edward G" uniqKey="Lakatta E" first="Edward G." last="Lakatta">Edward G. Lakatta</name><affiliation><nlm:aff id="A9">Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Laurent, Stephane" sort="Laurent, Stephane" uniqKey="Laurent S" first="Stephane" last="Laurent">Stephane Laurent</name><affiliation><nlm:aff id="A4">INSERM U 970, Paris-Descartes University, Hopital Europeen Geroges Pompidou, Assistance Publique Hopitaux de Paris, France</nlm:aff></affiliation></author><author><name sortKey="Maldonado, Joao" sort="Maldonado, Joao" uniqKey="Maldonado J" first="João" last="Maldonado">João Maldonado</name><affiliation><nlm:aff id="A10">Instituto de Investigação e Formação Cardiovascular, Penacova, Portugal</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Gary F" sort="Mitchell, Gary F" uniqKey="Mitchell G" first="Gary F." last="Mitchell">Gary F. Mitchell</name><affiliation><nlm:aff id="A11">Cardiovascular Engineering, Inc, Norwood, Mass, USA</nlm:aff></affiliation></author><author><name sortKey="Najjar, Samer S" sort="Najjar, Samer S" uniqKey="Najjar S" first="Samer S" last="Najjar">Samer S. Najjar</name><affiliation><nlm:aff id="A9">Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">MedStar Heart Research Institute, Washington DC, USA</nlm:aff></affiliation></author><author><name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name><affiliation><nlm:aff id="A13">Center for Aging and Population Health, Pittsburgh, USA</nlm:aff></affiliation></author><author><name sortKey="Ohishi, Mitsuru" sort="Ohishi, Mitsuru" uniqKey="Ohishi M" first="Mitsuru" last="Ohishi">Mitsuru Ohishi</name><affiliation><nlm:aff id="A14">Department of Geriatric Medicine, Osaka University, Japan</nlm:aff></affiliation></author><author><name sortKey="Pannier, Bruno" sort="Pannier, Bruno" uniqKey="Pannier B" first="Bruno" last="Pannier">Bruno Pannier</name><affiliation><nlm:aff id="A15">Centre d’Investigations Preventives et Cliniques, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Pereira, Telmo" sort="Pereira, Telmo" uniqKey="Pereira T" first="Telmo" last="Pereira">Telmo Pereira</name><affiliation><nlm:aff id="A16">Escola Superior de Tecnologia da Saúde de Coimbra, Coimbra, Portugal</nlm:aff></affiliation></author><author><name sortKey="Vasan, Ramachandran S" sort="Vasan, Ramachandran S" uniqKey="Vasan R" first="Ramachandran S" last="Vasan">Ramachandran S. Vasan</name><affiliation><nlm:aff id="A17">National Heart Lung and Blood Institute and Boston University’s Framingham Heart Study, Department of Medicine, Boston University, Boston, USA</nlm:aff></affiliation></author><author><name sortKey="Shokawa, Tomoki" sort="Shokawa, Tomoki" uniqKey="Shokawa T" first="Tomoki" last="Shokawa">Tomoki Shokawa</name><affiliation><nlm:aff id="A18">Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan</nlm:aff></affiliation></author><author><name sortKey="Sutton Tyrell, Kim" sort="Sutton Tyrell, Kim" uniqKey="Sutton Tyrell K" first="Kim" last="Sutton-Tyrell">Kim Sutton-Tyrell</name><affiliation><nlm:aff id="A13">Center for Aging and Population Health, Pittsburgh, USA</nlm:aff></affiliation></author><author><name sortKey="Verbeke, Francis" sort="Verbeke, Francis" uniqKey="Verbeke F" first="Francis" last="Verbeke">Francis Verbeke</name><affiliation><nlm:aff id="A19">Dept. of Nephrology, Ghent University Hospital, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Wang, Kang Ling" sort="Wang, Kang Ling" uniqKey="Wang K" first="Kang-Ling" last="Wang">Kang-Ling Wang</name><affiliation><nlm:aff id="A6">School of Medicine, National Yang-Ming University, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Webb, David J" sort="Webb, David J" uniqKey="Webb D" first="David J" last="Webb">David J. Webb</name><affiliation><nlm:aff id="A20">University/BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Hansen, Tine Willum" sort="Hansen, Tine Willum" uniqKey="Hansen T" first="Tine Willum" last="Hansen">Tine Willum Hansen</name><affiliation><nlm:aff id="A21">Research Center for Prevention and Health, Glostrup Hospital, Glostrup and Steno Diabetes Center, Denmark</nlm:aff></affiliation></author><author><name sortKey="Zoungas, Sophia" sort="Zoungas, Sophia" uniqKey="Zoungas S" first="Sophia" last="Zoungas">Sophia Zoungas</name><affiliation><nlm:aff id="A22">School of Public Health and Preventive Medicine, Monash University, Australia</nlm:aff></affiliation></author><author><name sortKey="Mceniery, Carmel M" sort="Mceniery, Carmel M" uniqKey="Mceniery C" first="Carmel M" last="Mceniery">Carmel M. Mceniery</name><affiliation><nlm:aff id="A23">Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Cockcroft, John R" sort="Cockcroft, John R" uniqKey="Cockcroft J" first="John R" last="Cockcroft">John R. Cockcroft</name><affiliation><nlm:aff id="A24">Wales Heart Research Institute, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Wilkinson, Ian B" sort="Wilkinson, Ian B" uniqKey="Wilkinson I" first="Ian B" last="Wilkinson">Ian B. Wilkinson</name><affiliation><nlm:aff id="A23">Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24239664</idno><idno type="pmc">4401072</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401072</idno><idno type="RBID">PMC:4401072</idno><idno type="doi">10.1016/j.jacc.2013.09.063</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002019</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002019</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects</title><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><affiliation><nlm:aff id="A1">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Spears, Melissa" sort="Spears, Melissa" uniqKey="Spears M" first="Melissa" last="Spears">Melissa Spears</name><affiliation><nlm:aff id="A1">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Boustred, Chris" sort="Boustred, Chris" uniqKey="Boustred C" first="Chris" last="Boustred">Chris Boustred</name><affiliation><nlm:aff id="A1">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="May, Margaret" sort="May, Margaret" uniqKey="May M" first="Margaret" last="May">Margaret May</name><affiliation><nlm:aff id="A1">School of Social and Community Medicine, University of Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Anderson, Simon G" sort="Anderson, Simon G" uniqKey="Anderson S" first="Simon G" last="Anderson">Simon G. Anderson</name><affiliation><nlm:aff id="A2">Manchester Medical School, Manchester, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Benjamin, Emelia J" sort="Benjamin, Emelia J" uniqKey="Benjamin E" first="Emelia J." last="Benjamin">Emelia J. Benjamin</name><affiliation><nlm:aff id="A3">National Heart Lung and Blood Institute and Boston University’s Framingham Heart Study, Cardiology Section, Department of Medicine, Boston University School of Medicine, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Boutouyrie, Pierre" sort="Boutouyrie, Pierre" uniqKey="Boutouyrie P" first="Pierre" last="Boutouyrie">Pierre Boutouyrie</name><affiliation><nlm:aff id="A4">INSERM U 970, Paris-Descartes University, Hopital Europeen Geroges Pompidou, Assistance Publique Hopitaux de Paris, France</nlm:aff></affiliation></author><author><name sortKey="Cameron, James" sort="Cameron, James" uniqKey="Cameron J" first="James" last="Cameron">James Cameron</name><affiliation><nlm:aff id="A5">Monash Cardiovascular Research Centre, MonashHEART and Monash University Department of Medicine (MMC), Melbourne, Australia, Australia</nlm:aff></affiliation></author><author><name sortKey="Chen, Chen Huan" sort="Chen, Chen Huan" uniqKey="Chen C" first="Chen-Huan" last="Chen">Chen-Huan Chen</name><affiliation><nlm:aff id="A6">School of Medicine, National Yang-Ming University, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Cruickshank, J Kennedy" sort="Cruickshank, J Kennedy" uniqKey="Cruickshank J" first="J Kennedy" last="Cruickshank">J Kennedy Cruickshank</name><affiliation><nlm:aff id="A7">King’s College & King’s Health Partners, St. Thomas’ & Guy’s Hospital, London</nlm:aff></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation><nlm:aff id="A8">Centre for Population Studies, National Heart, Lung and Blood Institute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Lakatta, Edward G" sort="Lakatta, Edward G" uniqKey="Lakatta E" first="Edward G." last="Lakatta">Edward G. Lakatta</name><affiliation><nlm:aff id="A9">Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Laurent, Stephane" sort="Laurent, Stephane" uniqKey="Laurent S" first="Stephane" last="Laurent">Stephane Laurent</name><affiliation><nlm:aff id="A4">INSERM U 970, Paris-Descartes University, Hopital Europeen Geroges Pompidou, Assistance Publique Hopitaux de Paris, France</nlm:aff></affiliation></author><author><name sortKey="Maldonado, Joao" sort="Maldonado, Joao" uniqKey="Maldonado J" first="João" last="Maldonado">João Maldonado</name><affiliation><nlm:aff id="A10">Instituto de Investigação e Formação Cardiovascular, Penacova, Portugal</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Gary F" sort="Mitchell, Gary F" uniqKey="Mitchell G" first="Gary F." last="Mitchell">Gary F. Mitchell</name><affiliation><nlm:aff id="A11">Cardiovascular Engineering, Inc, Norwood, Mass, USA</nlm:aff></affiliation></author><author><name sortKey="Najjar, Samer S" sort="Najjar, Samer S" uniqKey="Najjar S" first="Samer S" last="Najjar">Samer S. Najjar</name><affiliation><nlm:aff id="A9">Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">MedStar Heart Research Institute, Washington DC, USA</nlm:aff></affiliation></author><author><name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name><affiliation><nlm:aff id="A13">Center for Aging and Population Health, Pittsburgh, USA</nlm:aff></affiliation></author><author><name sortKey="Ohishi, Mitsuru" sort="Ohishi, Mitsuru" uniqKey="Ohishi M" first="Mitsuru" last="Ohishi">Mitsuru Ohishi</name><affiliation><nlm:aff id="A14">Department of Geriatric Medicine, Osaka University, Japan</nlm:aff></affiliation></author><author><name sortKey="Pannier, Bruno" sort="Pannier, Bruno" uniqKey="Pannier B" first="Bruno" last="Pannier">Bruno Pannier</name><affiliation><nlm:aff id="A15">Centre d’Investigations Preventives et Cliniques, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Pereira, Telmo" sort="Pereira, Telmo" uniqKey="Pereira T" first="Telmo" last="Pereira">Telmo Pereira</name><affiliation><nlm:aff id="A16">Escola Superior de Tecnologia da Saúde de Coimbra, Coimbra, Portugal</nlm:aff></affiliation></author><author><name sortKey="Vasan, Ramachandran S" sort="Vasan, Ramachandran S" uniqKey="Vasan R" first="Ramachandran S" last="Vasan">Ramachandran S. Vasan</name><affiliation><nlm:aff id="A17">National Heart Lung and Blood Institute and Boston University’s Framingham Heart Study, Department of Medicine, Boston University, Boston, USA</nlm:aff></affiliation></author><author><name sortKey="Shokawa, Tomoki" sort="Shokawa, Tomoki" uniqKey="Shokawa T" first="Tomoki" last="Shokawa">Tomoki Shokawa</name><affiliation><nlm:aff id="A18">Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan</nlm:aff></affiliation></author><author><name sortKey="Sutton Tyrell, Kim" sort="Sutton Tyrell, Kim" uniqKey="Sutton Tyrell K" first="Kim" last="Sutton-Tyrell">Kim Sutton-Tyrell</name><affiliation><nlm:aff id="A13">Center for Aging and Population Health, Pittsburgh, USA</nlm:aff></affiliation></author><author><name sortKey="Verbeke, Francis" sort="Verbeke, Francis" uniqKey="Verbeke F" first="Francis" last="Verbeke">Francis Verbeke</name><affiliation><nlm:aff id="A19">Dept. of Nephrology, Ghent University Hospital, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Wang, Kang Ling" sort="Wang, Kang Ling" uniqKey="Wang K" first="Kang-Ling" last="Wang">Kang-Ling Wang</name><affiliation><nlm:aff id="A6">School of Medicine, National Yang-Ming University, Taipei, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Webb, David J" sort="Webb, David J" uniqKey="Webb D" first="David J" last="Webb">David J. Webb</name><affiliation><nlm:aff id="A20">University/BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Hansen, Tine Willum" sort="Hansen, Tine Willum" uniqKey="Hansen T" first="Tine Willum" last="Hansen">Tine Willum Hansen</name><affiliation><nlm:aff id="A21">Research Center for Prevention and Health, Glostrup Hospital, Glostrup and Steno Diabetes Center, Denmark</nlm:aff></affiliation></author><author><name sortKey="Zoungas, Sophia" sort="Zoungas, Sophia" uniqKey="Zoungas S" first="Sophia" last="Zoungas">Sophia Zoungas</name><affiliation><nlm:aff id="A22">School of Public Health and Preventive Medicine, Monash University, Australia</nlm:aff></affiliation></author><author><name sortKey="Mceniery, Carmel M" sort="Mceniery, Carmel M" uniqKey="Mceniery C" first="Carmel M" last="Mceniery">Carmel M. Mceniery</name><affiliation><nlm:aff id="A23">Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Cockcroft, John R" sort="Cockcroft, John R" uniqKey="Cockcroft J" first="John R" last="Cockcroft">John R. Cockcroft</name><affiliation><nlm:aff id="A24">Wales Heart Research Institute, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Wilkinson, Ian B" sort="Wilkinson, Ian B" uniqKey="Wilkinson I" first="Ian B" last="Wilkinson">Ian B. Wilkinson</name><affiliation><nlm:aff id="A23">Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of the American College of Cardiology</title><idno type="ISSN">0735-1097</idno><idno type="eISSN">1558-3597</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title><p id="P1">To determine whether aortic pulse wave velocity (aPWV) improves prediction of cardiovascular (CVD) events beyond conventional risk factors.</p></sec><sec id="S2"><title>Background</title><p id="P2">Several studies have shown that aPWV may be a useful risk factor for predicting CVD but have been underpowered to examine whether this is true for different sub-groups.</p></sec><sec id="S3"><title>Methods</title><p id="P3">We undertook a systematic review and obtained individual participant data from 16 studies. Study-specific associations of aPWV with cardiovascular outcomes were determined using Cox proportional hazard models and random effect models to estimate pooled effects.</p></sec><sec id="S4"><title>Results</title><p id="P4">Of 17,635 participants, 1,785 (10%) had a cardiovascular (CVD) event. The pooled age- and sex-adjusted hazard ratio [95% CI] per SD change in log<sub>e</sub> aPWV was 1.35 [1.22, 1.50, p<0.001] for coronary heart disease (CHD), 1.54 [1.34, 1.78, p<0.001] for stroke, and 1.45 [1.30, 1.61, p<0.001) for CVD. Associations stratified by sex, diabetes and hypertension were similar, but decreased with age (1.89, 1.77, 1.36 and 1.23 for ≤50, 51–60, 61–70 and >70 years respectively, p<sub>interaction</sub> <0.001). After adjusting for conventional risk factors, aPWV remained a predictor: CHD 1.23, [1.11, 1.35 p<0.001]; stroke 1.28, [1.16, 1.42 p<0.001]; cardiovascular events 1.30 [1.18, 1.43, p<0.001]. Reclassification indices showed the addition of aPWV improved risk prediction (13% for 10 year CVD risk for intermediate risk) for some sub-groups.</p></sec><sec id="S5"><title>Conclusions</title><p id="P5">Consideration of aPWV improves model fit and reclassifies risk for future cardiovascular events in models that include standard risk factors. aPWV may enable better identification of high-risk populations who may benefit from more aggressive cardiovascular risk factor management.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8301365</journal-id><journal-id journal-id-type="pubmed-jr-id">4429</journal-id><journal-id journal-id-type="nlm-ta">J Am Coll Cardiol</journal-id><journal-id journal-id-type="iso-abbrev">J. Am. Coll. Cardiol.</journal-id><journal-title-group><journal-title>Journal of the American College of Cardiology</journal-title></journal-title-group><issn pub-type="ppub">0735-1097</issn><issn pub-type="epub">1558-3597</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24239664</article-id><article-id pub-id-type="pmc">4401072</article-id><article-id pub-id-type="doi">10.1016/j.jacc.2013.09.063</article-id><article-id pub-id-type="manuscript">NIHMS675218</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ben-Shlomo</surname><given-names>Yoav</given-names></name><degrees>MBBS PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Spears</surname><given-names>Melissa</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Boustred</surname><given-names>Chris</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>May</surname><given-names>Margaret</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Anderson</surname><given-names>Simon G</given-names></name><degrees>PhD MBBCh MRCP</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Benjamin</surname><given-names>Emelia J.</given-names></name><degrees>MD ScM</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Boutouyrie</surname><given-names>Pierre</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Cameron</surname><given-names>James</given-names></name><degrees>MBBS MD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Chen-Huan</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Cruickshank</surname><given-names>J Kennedy</given-names></name><degrees>MB MD</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Hwang</surname><given-names>Shih-Jen</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Lakatta</surname><given-names>Edward G.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Laurent</surname><given-names>Stephane</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Maldonado</surname><given-names>João</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Mitchell</surname><given-names>Gary F.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Najjar</surname><given-names>Samer S</given-names></name><degrees>MD FACC</degrees><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Newman</surname><given-names>Anne B.</given-names></name><degrees>MD MPH</degrees><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Ohishi</surname><given-names>Mitsuru</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Pannier</surname><given-names>Bruno</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Pereira</surname><given-names>Telmo</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Vasan</surname><given-names>Ramachandran S</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Shokawa</surname><given-names>Tomoki</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Sutton-Tyrell</surname><given-names>Kim</given-names></name><degrees>DrPH</degrees><xref ref-type="aff" rid="A13">13</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Verbeke</surname><given-names>Francis</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Kang-Ling</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Webb</surname><given-names>David J</given-names></name><degrees>MD DSc FRSE</degrees><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Hansen</surname><given-names>Tine Willum</given-names></name><degrees>MD PhD</degrees><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Zoungas</surname><given-names>Sophia</given-names></name><degrees>MBBS PhD FRACP</degrees><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>McEniery</surname><given-names>Carmel M</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Cockcroft</surname><given-names>John R</given-names></name><degrees>BSc MB FRCP</degrees><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Wilkinson</surname><given-names>Ian B</given-names></name><degrees>MA DM FRCP</degrees><xref ref-type="aff" rid="A23">23</xref></contrib></contrib-group><aff id="A1"><label>1</label>School of Social and Community Medicine, University of Bristol, UK</aff><aff id="A2"><label>2</label>Manchester Medical School, Manchester, United Kingdom</aff><aff id="A3"><label>3</label>National Heart Lung and Blood Institute and Boston University’s Framingham Heart Study, Cardiology Section, Department of Medicine, Boston University School of Medicine, Boston, MA, USA</aff><aff id="A4"><label>4</label>INSERM U 970, Paris-Descartes University, Hopital Europeen Geroges Pompidou, Assistance Publique Hopitaux de Paris, France</aff><aff id="A5"><label>5</label>Monash Cardiovascular Research Centre, MonashHEART and Monash University Department of Medicine (MMC), Melbourne, Australia, Australia</aff><aff id="A6"><label>6</label>School of Medicine, National Yang-Ming University, Taipei, Taiwan</aff><aff id="A7"><label>7</label>King’s College & King’s Health Partners, St. Thomas’ & Guy’s Hospital, London</aff><aff id="A8"><label>8</label>Centre for Population Studies, National Heart, Lung and Blood Institute, Bethesda, USA</aff><aff id="A9"><label>9</label>Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA</aff><aff id="A10"><label>10</label>Instituto de Investigação e Formação Cardiovascular, Penacova, Portugal</aff><aff id="A11"><label>11</label>Cardiovascular Engineering, Inc, Norwood, Mass, USA</aff><aff id="A12"><label>12</label>MedStar Heart Research Institute, Washington DC, USA</aff><aff id="A13"><label>13</label>Center for Aging and Population Health, Pittsburgh, USA</aff><aff id="A14"><label>14</label>Department of Geriatric Medicine, Osaka University, Japan</aff><aff id="A15"><label>15</label>Centre d’Investigations Preventives et Cliniques, Paris, France</aff><aff id="A16"><label>16</label>Escola Superior de Tecnologia da Saúde de Coimbra, Coimbra, Portugal</aff><aff id="A17"><label>17</label>National Heart Lung and Blood Institute and Boston University’s Framingham Heart Study, Department of Medicine, Boston University, Boston, USA</aff><aff id="A18"><label>18</label>Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan</aff><aff id="A19"><label>19</label>Dept. of Nephrology, Ghent University Hospital, Ghent, Belgium</aff><aff id="A20"><label>20</label>University/BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK</aff><aff id="A21"><label>21</label>Research Center for Prevention and Health, Glostrup Hospital, Glostrup and Steno Diabetes Center, Denmark</aff><aff id="A22"><label>22</label>School of Public Health and Preventive Medicine, Monash University, Australia</aff><aff id="A23"><label>23</label>Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom</aff><aff id="A24"><label>24</label>Wales Heart Research Institute, Cardiff, UK</aff><author-notes><corresp id="FN1"><bold>Author for correspondence:</bold> Yoav Ben-Shlomo; School of Social and Community Medicine, 39 Whatley Road, Bristol BS8 2PS, tel +44117 928 7206; fax +441179287325</corresp><fn id="FN2"><label>*</label><p>Dr. Sutton-Tyrell sadly passed away before the revised version of the manuscript.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>27</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>13</day><month>11</month><year>2013</year></pub-date><pub-date pub-type="ppub"><day>25</day><month>2</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>17</day><month>4</month><year>2015</year></pub-date><volume>63</volume><issue>7</issue><fpage>636</fpage><lpage>646</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.jacc.2013.09.063</pmc-comment>
<abstract><sec id="S1"><title>Objectives</title><p id="P1">To determine whether aortic pulse wave velocity (aPWV) improves prediction of cardiovascular (CVD) events beyond conventional risk factors.</p></sec><sec id="S2"><title>Background</title><p id="P2">Several studies have shown that aPWV may be a useful risk factor for predicting CVD but have been underpowered to examine whether this is true for different sub-groups.</p></sec><sec id="S3"><title>Methods</title><p id="P3">We undertook a systematic review and obtained individual participant data from 16 studies. Study-specific associations of aPWV with cardiovascular outcomes were determined using Cox proportional hazard models and random effect models to estimate pooled effects.</p></sec><sec id="S4"><title>Results</title><p id="P4">Of 17,635 participants, 1,785 (10%) had a cardiovascular (CVD) event. The pooled age- and sex-adjusted hazard ratio [95% CI] per SD change in log<sub>e</sub> aPWV was 1.35 [1.22, 1.50, p<0.001] for coronary heart disease (CHD), 1.54 [1.34, 1.78, p<0.001] for stroke, and 1.45 [1.30, 1.61, p<0.001) for CVD. Associations stratified by sex, diabetes and hypertension were similar, but decreased with age (1.89, 1.77, 1.36 and 1.23 for ≤50, 51–60, 61–70 and >70 years respectively, p<sub>interaction</sub> <0.001). After adjusting for conventional risk factors, aPWV remained a predictor: CHD 1.23, [1.11, 1.35 p<0.001]; stroke 1.28, [1.16, 1.42 p<0.001]; cardiovascular events 1.30 [1.18, 1.43, p<0.001]. Reclassification indices showed the addition of aPWV improved risk prediction (13% for 10 year CVD risk for intermediate risk) for some sub-groups.</p></sec><sec id="S5"><title>Conclusions</title><p id="P5">Consideration of aPWV improves model fit and reclassifies risk for future cardiovascular events in models that include standard risk factors. aPWV may enable better identification of high-risk populations who may benefit from more aggressive cardiovascular risk factor management.</p></sec></abstract><kwd-group><kwd>pulse wave velocity</kwd><kwd>meta-analysis</kwd><kwd>cardiovascular disease</kwd><kwd>prognostic factor</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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