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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Erasing fear memories with extinction training</title><author><name sortKey="Quirk, Gregory J" sort="Quirk, Gregory J" uniqKey="Quirk G" first="Gregory J." last="Quirk">Gregory J. Quirk</name><affiliation><nlm:aff id="A1">Departments of Psychiatry and Anatomy & Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico</nlm:aff></affiliation></author><author><name sortKey="Pare, Denis" sort="Pare, Denis" uniqKey="Pare D" first="Denis" last="Paré">Denis Paré</name><affiliation><nlm:aff id="A2">Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102</nlm:aff></affiliation></author><author><name sortKey="Richardson, Rick" sort="Richardson, Rick" uniqKey="Richardson R" first="Rick" last="Richardson">Rick Richardson</name><affiliation><nlm:aff id="A3">School of Psychology, The University of New South Wales, Kensington, Sydney, New South Wales 2052, Australia</nlm:aff></affiliation></author><author><name sortKey="Herry, Cyril" sort="Herry, Cyril" uniqKey="Herry C" first="Cyril" last="Herry">Cyril Herry</name><affiliation><nlm:aff id="A4">INSERM U862, Neurocentre Magendie, Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="Monfils, Marie H" sort="Monfils, Marie H" uniqKey="Monfils M" first="Marie H." last="Monfils">Marie H. Monfils</name><affiliation><nlm:aff id="A5">Department of Psychology, University of Texas, Austin, TX 78712</nlm:aff></affiliation></author><author><name sortKey="Schiller, Daniela" sort="Schiller, Daniela" uniqKey="Schiller D" first="Daniela" last="Schiller">Daniela Schiller</name><affiliation><nlm:aff id="A6">Center for Neural Science, New York University, New York, NY 10003</nlm:aff></affiliation></author><author><name sortKey="Vicentic, Aleksandra" sort="Vicentic, Aleksandra" uniqKey="Vicentic A" first="Aleksandra" last="Vicentic">Aleksandra Vicentic</name><affiliation><nlm:aff id="A7">National Institute of Mental Health, Rockville, MD 20852</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21068303</idno><idno type="pmc">3380534</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380534</idno><idno type="RBID">PMC:3380534</idno><idno type="doi">10.1523/JNEUROSCI.4268-10.2010</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">002002</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002002</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Erasing fear memories with extinction training</title><author><name sortKey="Quirk, Gregory J" sort="Quirk, Gregory J" uniqKey="Quirk G" first="Gregory J." last="Quirk">Gregory J. Quirk</name><affiliation><nlm:aff id="A1">Departments of Psychiatry and Anatomy & Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico</nlm:aff></affiliation></author><author><name sortKey="Pare, Denis" sort="Pare, Denis" uniqKey="Pare D" first="Denis" last="Paré">Denis Paré</name><affiliation><nlm:aff id="A2">Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102</nlm:aff></affiliation></author><author><name sortKey="Richardson, Rick" sort="Richardson, Rick" uniqKey="Richardson R" first="Rick" last="Richardson">Rick Richardson</name><affiliation><nlm:aff id="A3">School of Psychology, The University of New South Wales, Kensington, Sydney, New South Wales 2052, Australia</nlm:aff></affiliation></author><author><name sortKey="Herry, Cyril" sort="Herry, Cyril" uniqKey="Herry C" first="Cyril" last="Herry">Cyril Herry</name><affiliation><nlm:aff id="A4">INSERM U862, Neurocentre Magendie, Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="Monfils, Marie H" sort="Monfils, Marie H" uniqKey="Monfils M" first="Marie H." last="Monfils">Marie H. Monfils</name><affiliation><nlm:aff id="A5">Department of Psychology, University of Texas, Austin, TX 78712</nlm:aff></affiliation></author><author><name sortKey="Schiller, Daniela" sort="Schiller, Daniela" uniqKey="Schiller D" first="Daniela" last="Schiller">Daniela Schiller</name><affiliation><nlm:aff id="A6">Center for Neural Science, New York University, New York, NY 10003</nlm:aff></affiliation></author><author><name sortKey="Vicentic, Aleksandra" sort="Vicentic, Aleksandra" uniqKey="Vicentic A" first="Aleksandra" last="Vicentic">Aleksandra Vicentic</name><affiliation><nlm:aff id="A7">National Institute of Mental Health, Rockville, MD 20852</nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Neuroscience</title><idno type="ISSN">0270-6474</idno><idno type="eISSN">1529-2401</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Decades of behavioral studies have confirmed that extinction does not erase classically-conditioned fear memories. For this reason, research efforts have focused on the mechanisms underlying the development of extinction-induced inhibition within fear circuits. However, recent studies in rodents have uncovered mechanisms that stabilize and destabilize fear memories, opening the possibility that extinction might be used to erase fear memories. This symposium focuses on several of these new developments, which involve the timing of extinction training. Extinction-induced erasure of fear occurs in very young rats, but is lost with the development of perineuronal nets in the amygdala that render fear memories impervious to extinction. Moreover, extinction administered during the reconsolidation phase, when fear memory is destabilized, updates the fear association as safe, thereby preventing the return of fear, in both rats and humans. The use of modified extinction protocols to eliminate fear memories complements existing pharmacological strategies for strengthening extinction.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8102140</journal-id><journal-id journal-id-type="pubmed-jr-id">5035</journal-id><journal-id journal-id-type="nlm-ta">J Neurosci</journal-id><journal-id journal-id-type="iso-abbrev">J. Neurosci.</journal-id><journal-title-group><journal-title>The Journal of Neuroscience</journal-title></journal-title-group><issn pub-type="ppub">0270-6474</issn><issn pub-type="epub">1529-2401</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21068303</article-id><article-id pub-id-type="pmc">3380534</article-id><article-id pub-id-type="doi">10.1523/JNEUROSCI.4268-10.2010</article-id><article-id pub-id-type="manuscript">NIHMS251201</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Erasing fear memories with extinction training</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Quirk</surname><given-names>Gregory J.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Paré</surname><given-names>Denis</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Richardson</surname><given-names>Rick</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Herry</surname><given-names>Cyril</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Monfils</surname><given-names>Marie H.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Schiller</surname><given-names>Daniela</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Vicentic</surname><given-names>Aleksandra</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib></contrib-group><aff id="A1"><label>1</label>Departments of Psychiatry and Anatomy & Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico</aff><aff id="A2"><label>2</label>Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102</aff><aff id="A3"><label>3</label>School of Psychology, The University of New South Wales, Kensington, Sydney, New South Wales 2052, Australia</aff><aff id="A4"><label>4</label>INSERM U862, Neurocentre Magendie, Bordeaux, France</aff><aff id="A5"><label>5</label>Department of Psychology, University of Texas, Austin, TX 78712</aff><aff id="A6"><label>6</label>Center for Neural Science, New York University, New York, NY 10003</aff><aff id="A7"><label>7</label>National Institute of Mental Health, Rockville, MD 20852</aff><author-notes><corresp id="FN1">Corresponding author: Gregory J. Quirk, PhD, Dept of Psychiatry, University of Puerto Rico, School of Medicine, PO Box 365067, San Juan, PR 00936-5067, Tel: (787)999-3058; Fax: (787)999-3057 <email>gjquirk@yahoo.com</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>6</month><year>2012</year></pub-date><pub-date pub-type="ppub"><day>10</day><month>11</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>21</day><month>6</month><year>2012</year></pub-date><volume>30</volume><issue>45</issue><fpage>14993</fpage><lpage>14997</lpage><abstract><p id="P1">Decades of behavioral studies have confirmed that extinction does not erase classically-conditioned fear memories. For this reason, research efforts have focused on the mechanisms underlying the development of extinction-induced inhibition within fear circuits. However, recent studies in rodents have uncovered mechanisms that stabilize and destabilize fear memories, opening the possibility that extinction might be used to erase fear memories. This symposium focuses on several of these new developments, which involve the timing of extinction training. Extinction-induced erasure of fear occurs in very young rats, but is lost with the development of perineuronal nets in the amygdala that render fear memories impervious to extinction. Moreover, extinction administered during the reconsolidation phase, when fear memory is destabilized, updates the fear association as safe, thereby preventing the return of fear, in both rats and humans. The use of modified extinction protocols to eliminate fear memories complements existing pharmacological strategies for strengthening extinction.</p></abstract><funding-group><award-group><funding-source country="United States">National Institute of Mental Health : NIMH</funding-source><award-id>R01 MH081975 || MH</award-id></award-group><award-group><funding-source country="United States">National Institute of Mental Health : NIMH</funding-source><award-id>R01 MH058883 || MH</award-id></award-group><award-group><funding-source country="United States">National Institute of Mental Health : NIMH</funding-source><award-id>P50 MH086400 || MH</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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