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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association of Alzheimer disease GWAS loci with MRI-markers of brain aging</title><author><name sortKey="Chauhan, Ganesh" sort="Chauhan, Ganesh" uniqKey="Chauhan G" first="Ganesh" last="Chauhan">Ganesh Chauhan</name><affiliation><nlm:aff id="A1">INSERM U740 (Paris 7 University) and U708 (Bordeaux University), France</nlm:aff></affiliation></author><author><name sortKey="Adams, Hieab H H" sort="Adams, Hieab H H" uniqKey="Adams H" first="Hieab H. H." last="Adams">Hieab H. H. Adams</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name><affiliation><nlm:aff id="A4">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Weinstein, Galit" sort="Weinstein, Galit" uniqKey="Weinstein G" first="Galit" last="Weinstein">Galit Weinstein</name><affiliation><nlm:aff id="A5">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">The Framingham Heart Study, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><affiliation><nlm:aff id="A7">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Toglhofer, Anna Maria" sort="Toglhofer, Anna Maria" uniqKey="Toglhofer A" first="Anna Maria" last="Töglhofer">Anna Maria Töglhofer</name><affiliation><nlm:aff id="A9">Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation><nlm:aff id="A10">Icelandic Heart Association, Kopavogur Capital Region, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Department of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Van Der Lee, Sven" sort="Van Der Lee, Sven" uniqKey="Van Der Lee S" first="Sven" last="Van Der Lee">Sven Van Der Lee</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gottesman, Rebecca F" sort="Gottesman, Rebecca F" uniqKey="Gottesman R" first="Rebecca F" last="Gottesman">Rebecca F. Gottesman</name><affiliation><nlm:aff id="A12">Department of Neurology, Johns Hopkins School of Medicine, Baltimore, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA</nlm:aff></affiliation></author><author><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name><affiliation><nlm:aff id="A14">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia</nlm:aff></affiliation></author><author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><affiliation><nlm:aff id="A6">The Framingham Heart Study, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation><nlm:aff id="A6">The Framingham Heart Study, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><affiliation><nlm:aff id="A3">Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L" last="Lopez">Oscar L. Lopez</name><affiliation><nlm:aff id="A16">Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T" last="Becker">James T. Becker</name><affiliation><nlm:aff id="A16">Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Phan, Thanh G" sort="Phan, Thanh G" uniqKey="Phan T" first="Thanh G" last="Phan">Thanh G. Phan</name><affiliation><nlm:aff id="A19">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J" last="Beare">Richard J. Beare</name><affiliation><nlm:aff id="A19">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Developmental Imaging Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Parkville, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name><affiliation><nlm:aff id="A7">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Fleischman, Debra" sort="Fleischman, Debra" uniqKey="Fleischman D" first="Debra" last="Fleischman">Debra Fleischman</name><affiliation><nlm:aff id="A7">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W." last="Vernooij">Meike W. Vernooij</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name><affiliation><nlm:aff id="A22">CNRS-CEA UMR5296, Université Bordeaux Segalen, Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation><nlm:aff id="A9">Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name><affiliation><nlm:aff id="A19">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia</nlm:aff></affiliation></author><author><name sortKey="Knopman, Dave S" sort="Knopman, Dave S" uniqKey="Knopman D" first="Dave S" last="Knopman">Dave S. Knopman</name><affiliation><nlm:aff id="A23">Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R" last="Jack">Clifford R. Jack</name><affiliation><nlm:aff id="A24">Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation><nlm:aff id="A25">Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A26">INSERM, U744, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Université Lille 2, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Decarli, Charlie" sort="Decarli, Charlie" uniqKey="Decarli C" first="Charlie" last="Decarli">Charlie Decarli</name><affiliation><nlm:aff id="A28">Department of Neurology, University of California at Davis, Davis, California, USA</nlm:aff></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation><nlm:aff id="A29">Department of Neuroepidemiology, INSERM U708, Bordeaux, France</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Université Victor Segalen Bordeaux 2, France</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Netherlands Consortium for Healthy Aging, Leiden, Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Center for Medical Systems Biology, Leiden, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A" last="Bennett">David A. Bennett</name><affiliation><nlm:aff id="A7">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation><nlm:aff id="A33">Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Longstreth, William T" sort="Longstreth, William T" uniqKey="Longstreth W" first="William T" last="Longstreth">William T. Longstreth</name><affiliation><nlm:aff id="A34">Departments of Neurology and Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name><affiliation><nlm:aff id="A35">Department of Medicine-Geriatrics/Gerontology, University of Mississippi Medical Center, Jackson, Mississippi, USA</nlm:aff></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation><nlm:aff id="A36">The Human Genetics Center and Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, USA</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A37">Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation><nlm:aff id="A5">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">The Framingham Heart Study, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Netherlands Consortium for Healthy Aging, Leiden, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><affiliation><nlm:aff id="A1">INSERM U740 (Paris 7 University) and U708 (Bordeaux University), France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Neurology, Lariboisière Hospital, Paris 7 University, DHU Neurovasc Paris Sorbonne, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">University of Versailles Saint-Quentin-en-Yvelines, France</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25670335</idno><idno type="pmc">4391343</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391343</idno><idno type="RBID">PMC:4391343</idno><idno type="doi">10.1016/j.neurobiolaging.2014.12.028</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001F97</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F97</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association of Alzheimer disease GWAS loci with MRI-markers of brain aging</title><author><name sortKey="Chauhan, Ganesh" sort="Chauhan, Ganesh" uniqKey="Chauhan G" first="Ganesh" last="Chauhan">Ganesh Chauhan</name><affiliation><nlm:aff id="A1">INSERM U740 (Paris 7 University) and U708 (Bordeaux University), France</nlm:aff></affiliation></author><author><name sortKey="Adams, Hieab H H" sort="Adams, Hieab H H" uniqKey="Adams H" first="Hieab H. H." last="Adams">Hieab H. H. Adams</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name><affiliation><nlm:aff id="A4">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Weinstein, Galit" sort="Weinstein, Galit" uniqKey="Weinstein G" first="Galit" last="Weinstein">Galit Weinstein</name><affiliation><nlm:aff id="A5">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">The Framingham Heart Study, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><affiliation><nlm:aff id="A7">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Toglhofer, Anna Maria" sort="Toglhofer, Anna Maria" uniqKey="Toglhofer A" first="Anna Maria" last="Töglhofer">Anna Maria Töglhofer</name><affiliation><nlm:aff id="A9">Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation><nlm:aff id="A10">Icelandic Heart Association, Kopavogur Capital Region, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Department of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Van Der Lee, Sven" sort="Van Der Lee, Sven" uniqKey="Van Der Lee S" first="Sven" last="Van Der Lee">Sven Van Der Lee</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gottesman, Rebecca F" sort="Gottesman, Rebecca F" uniqKey="Gottesman R" first="Rebecca F" last="Gottesman">Rebecca F. Gottesman</name><affiliation><nlm:aff id="A12">Department of Neurology, Johns Hopkins School of Medicine, Baltimore, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA</nlm:aff></affiliation></author><author><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name><affiliation><nlm:aff id="A14">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia</nlm:aff></affiliation></author><author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><affiliation><nlm:aff id="A6">The Framingham Heart Study, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation><nlm:aff id="A6">The Framingham Heart Study, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><affiliation><nlm:aff id="A3">Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L" last="Lopez">Oscar L. Lopez</name><affiliation><nlm:aff id="A16">Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T" last="Becker">James T. Becker</name><affiliation><nlm:aff id="A16">Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Phan, Thanh G" sort="Phan, Thanh G" uniqKey="Phan T" first="Thanh G" last="Phan">Thanh G. Phan</name><affiliation><nlm:aff id="A19">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J" last="Beare">Richard J. Beare</name><affiliation><nlm:aff id="A19">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Developmental Imaging Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Parkville, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name><affiliation><nlm:aff id="A7">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Fleischman, Debra" sort="Fleischman, Debra" uniqKey="Fleischman D" first="Debra" last="Fleischman">Debra Fleischman</name><affiliation><nlm:aff id="A7">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W." last="Vernooij">Meike W. Vernooij</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name><affiliation><nlm:aff id="A22">CNRS-CEA UMR5296, Université Bordeaux Segalen, Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation><nlm:aff id="A9">Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name><affiliation><nlm:aff id="A19">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia</nlm:aff></affiliation></author><author><name sortKey="Knopman, Dave S" sort="Knopman, Dave S" uniqKey="Knopman D" first="Dave S" last="Knopman">Dave S. Knopman</name><affiliation><nlm:aff id="A23">Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R" last="Jack">Clifford R. Jack</name><affiliation><nlm:aff id="A24">Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation><nlm:aff id="A25">Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A26">INSERM, U744, Lille, France</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Université Lille 2, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Decarli, Charlie" sort="Decarli, Charlie" uniqKey="Decarli C" first="Charlie" last="Decarli">Charlie Decarli</name><affiliation><nlm:aff id="A28">Department of Neurology, University of California at Davis, Davis, California, USA</nlm:aff></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation><nlm:aff id="A29">Department of Neuroepidemiology, INSERM U708, Bordeaux, France</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Université Victor Segalen Bordeaux 2, France</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Netherlands Consortium for Healthy Aging, Leiden, Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Center for Medical Systems Biology, Leiden, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A" last="Bennett">David A. Bennett</name><affiliation><nlm:aff id="A7">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation><nlm:aff id="A33">Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Longstreth, William T" sort="Longstreth, William T" uniqKey="Longstreth W" first="William T" last="Longstreth">William T. Longstreth</name><affiliation><nlm:aff id="A34">Departments of Neurology and Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name><affiliation><nlm:aff id="A35">Department of Medicine-Geriatrics/Gerontology, University of Mississippi Medical Center, Jackson, Mississippi, USA</nlm:aff></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation><nlm:aff id="A36">The Human Genetics Center and Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, USA</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A37">Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation><nlm:aff id="A5">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">The Framingham Heart Study, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Netherlands Consortium for Healthy Aging, Leiden, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><affiliation><nlm:aff id="A1">INSERM U740 (Paris 7 University) and U708 (Bordeaux University), France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Neurology, Lariboisière Hospital, Paris 7 University, DHU Neurovasc Paris Sorbonne, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">University of Versailles Saint-Quentin-en-Yvelines, France</nlm:aff></affiliation></author></analytic><series><title level="j">Neurobiology of aging</title><idno type="ISSN">0197-4580</idno><idno type="eISSN">1558-1497</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Whether novel risk variants of Alzheimer’s disease (AD) identified through genome-wide association studies (GWAS) also influence MRI-based intermediate phenotypes of AD in the general population is unclear. We studied association of 24 AD risk loci with intracranial volume (ICV), total brain volume (TBV), hippocampal volume (HV), white matter hyperintensity (WMH) burden, and brain infarcts in a meta-analysis of genetic association studies from large population-based samples (N=8,175–11,550). In single-SNP based tests, AD risk allele of <italic>APOE</italic> (rs2075650) was associated with smaller HV (p=0.0054) and <italic>CD33</italic> (rs3865444) with smaller ICV (p=0.0058) In gene-based tests, there was associations of <italic>HLA-DRB1</italic> with TBV (p=0.0006) and <italic>BIN1</italic> with HV (p=0.00089). A weighted AD genetic risk score was associated with smaller HV (beta±SE=−0.047±0.013, p=0.00041), even after excluding the <italic>APOE</italic> locus (p=0.029). However, only association of AD genetic risk score with HV, including <italic>APOE</italic>, was significant after multiple testing correction (including number of independent phenotypes tested). These results suggest that novel AD genetic risk variants may contribute to structural brain aging in non-demented older community persons.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8100437</journal-id><journal-id journal-id-type="pubmed-jr-id">6047</journal-id><journal-id journal-id-type="nlm-ta">Neurobiol Aging</journal-id><journal-id journal-id-type="iso-abbrev">Neurobiol. Aging</journal-id><journal-title-group><journal-title>Neurobiology of aging</journal-title></journal-title-group><issn pub-type="ppub">0197-4580</issn><issn pub-type="epub">1558-1497</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25670335</article-id><article-id pub-id-type="pmc">4391343</article-id><article-id pub-id-type="doi">10.1016/j.neurobiolaging.2014.12.028</article-id><article-id pub-id-type="manuscript">NIHMS662441</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Association of Alzheimer disease GWAS loci with MRI-markers of brain aging</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chauhan</surname><given-names>Ganesh</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Adams</surname><given-names>Hieab H.H.</given-names></name><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A3">c</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Bis</surname><given-names>Joshua C</given-names></name><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Weinstein</surname><given-names>Galit</given-names></name><xref ref-type="aff" rid="A5">e</xref><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>Lei</given-names></name><xref ref-type="aff" rid="A7">g</xref><xref ref-type="aff" rid="A8">h</xref></contrib><contrib contrib-type="author"><name><surname>Töglhofer</surname><given-names>Anna Maria</given-names></name><xref ref-type="aff" rid="A9">i</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Albert Vernon</given-names></name><xref ref-type="aff" rid="A10">j</xref><xref ref-type="aff" rid="A11">k</xref></contrib><contrib contrib-type="author"><name><surname>van der Lee</surname><given-names>Sven</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Gottesman</surname><given-names>Rebecca F</given-names></name><xref ref-type="aff" rid="A12">l</xref><xref ref-type="aff" rid="A13">m</xref></contrib><contrib contrib-type="author"><name><surname>Thomson</surname><given-names>Russell</given-names></name><xref ref-type="aff" rid="A14">n</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Jing</given-names></name><xref ref-type="aff" rid="A6">f</xref><xref ref-type="aff" rid="A15">o</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Qiong</given-names></name><xref ref-type="aff" rid="A6">f</xref><xref ref-type="aff" rid="A15">o</xref></contrib><contrib contrib-type="author"><name><surname>Niessen</surname><given-names>Wiro J.</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Lopez</surname><given-names>Oscar L</given-names></name><xref ref-type="aff" rid="A16">p</xref><xref ref-type="aff" rid="A17">q</xref></contrib><contrib contrib-type="author"><name><surname>Becker</surname><given-names>James T</given-names></name><xref ref-type="aff" rid="A16">p</xref><xref ref-type="aff" rid="A17">q</xref><xref ref-type="aff" rid="A18">r</xref></contrib><contrib contrib-type="author"><name><surname>Phan</surname><given-names>Thanh G</given-names></name><xref ref-type="aff" rid="A19">s</xref></contrib><contrib contrib-type="author"><name><surname>Beare</surname><given-names>Richard J</given-names></name><xref ref-type="aff" rid="A19">s</xref><xref ref-type="aff" rid="A20">t</xref></contrib><contrib contrib-type="author"><name><surname>Arfanakis</surname><given-names>Konstantinos</given-names></name><xref ref-type="aff" rid="A7">g</xref><xref ref-type="aff" rid="A21">u</xref></contrib><contrib contrib-type="author"><name><surname>Fleischman</surname><given-names>Debra</given-names></name><xref ref-type="aff" rid="A7">g</xref></contrib><contrib contrib-type="author"><name><surname>Vernooij</surname><given-names>Meike W.</given-names></name><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Mazoyer</surname><given-names>Bernard</given-names></name><xref ref-type="aff" rid="A22">v</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Helena</given-names></name><xref ref-type="aff" rid="A9">i</xref></contrib><contrib contrib-type="author"><name><surname>Srikanth</surname><given-names>Velandai</given-names></name><xref ref-type="aff" rid="A19">s</xref><xref ref-type="aff" rid="A14">n</xref></contrib><contrib contrib-type="author"><name><surname>Knopman</surname><given-names>Dave S</given-names></name><xref ref-type="aff" rid="A23">w</xref></contrib><contrib contrib-type="author"><name><surname>Jack</surname><given-names>Clifford R</given-names><suffix>Jr</suffix></name><xref ref-type="aff" rid="A24">x</xref></contrib><contrib contrib-type="author"><name><surname>Amouyel</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="A25">y</xref><xref ref-type="aff" rid="A26">z</xref><xref ref-type="aff" rid="A27">aa</xref></contrib><contrib contrib-type="author"><name><surname>Hofman</surname><given-names>Albert</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>DeCarli</surname><given-names>Charlie</given-names></name><xref ref-type="aff" rid="A28">ab</xref></contrib><contrib contrib-type="author"><name><surname>Tzourio</surname><given-names>Christophe</given-names></name><xref ref-type="aff" rid="A29">ac</xref><xref ref-type="aff" rid="A30">ad</xref></contrib><contrib contrib-type="author"><name><surname>van Duijn</surname><given-names>Cornelia M</given-names></name><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A31">ae</xref><xref ref-type="aff" rid="A32">af</xref></contrib><contrib contrib-type="author"><name><surname>Bennett</surname><given-names>David A</given-names></name><xref ref-type="aff" rid="A7">g</xref><xref ref-type="aff" rid="A8">h</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Reinhold</given-names></name><xref ref-type="aff" rid="A33">ag</xref></contrib><contrib contrib-type="author"><name><surname>Longstreth</surname><given-names>William T</given-names><suffix>Jr</suffix></name><xref ref-type="aff" rid="A34">ah</xref></contrib><contrib contrib-type="author"><name><surname>Mosley</surname><given-names>Thomas H</given-names></name><xref ref-type="aff" rid="A35">ai</xref></contrib><contrib contrib-type="author"><name><surname>Fornage</surname><given-names>Myriam</given-names></name><xref ref-type="aff" rid="A36">aj</xref></contrib><contrib contrib-type="author"><name><surname>Launer</surname><given-names>Lenore J</given-names></name><xref ref-type="aff" rid="A37">ak</xref></contrib><contrib contrib-type="author"><name><surname>Seshadri</surname><given-names>Sudha</given-names></name><xref ref-type="aff" rid="A5">e</xref><xref ref-type="aff" rid="A6">f</xref><xref rid="FN3" ref-type="author-notes">§</xref></contrib><contrib contrib-type="author"><name><surname>Ikram</surname><given-names>M Arfan</given-names></name><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A3">c</xref><xref ref-type="aff" rid="A31">ae</xref><xref rid="FN3" ref-type="author-notes">§</xref></contrib><contrib contrib-type="author"><name><surname>Debette</surname><given-names>Stephanie</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A5">e</xref><xref ref-type="aff" rid="A38">al</xref><xref ref-type="aff" rid="A39">am</xref><xref rid="FN3" ref-type="author-notes">§</xref></contrib></contrib-group><aff id="A1"><label>a</label>INSERM U740 (Paris 7 University) and U708 (Bordeaux University), France</aff><aff id="A2"><label>b</label>Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</aff><aff id="A3"><label>c</label>Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands</aff><aff id="A4"><label>d</label>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA</aff><aff id="A5"><label>e</label>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA</aff><aff id="A6"><label>f</label>The Framingham Heart Study, Boston, Massachusetts, USA</aff><aff id="A7"><label>g</label>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</aff><aff id="A8"><label>h</label>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</aff><aff id="A9"><label>i</label>Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Austria</aff><aff id="A10"><label>j</label>Icelandic Heart Association, Kopavogur Capital Region, Iceland</aff><aff id="A11"><label>k</label>Department of Medicine, University of Iceland, Reykjavik, Iceland</aff><aff id="A12"><label>l</label>Department of Neurology, Johns Hopkins School of Medicine, Baltimore, USA</aff><aff id="A13"><label>m</label>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA</aff><aff id="A14"><label>n</label>Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia</aff><aff id="A15"><label>o</label>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA</aff><aff id="A16"><label>p</label>Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</aff><aff id="A17"><label>q</label>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</aff><aff id="A18"><label>r</label>Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</aff><aff id="A19"><label>s</label>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Victoria, Australia</aff><aff id="A20"><label>t</label>Developmental Imaging Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Parkville, Victoria, Australia</aff><aff id="A21"><label>u</label>Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA</aff><aff id="A22"><label>v</label>CNRS-CEA UMR5296, Université Bordeaux Segalen, Bordeaux, France</aff><aff id="A23"><label>w</label>Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA</aff><aff id="A24"><label>x</label>Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, USA</aff><aff id="A25"><label>y</label>Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France</aff><aff id="A26"><label>z</label>INSERM, U744, Lille, France</aff><aff id="A27"><label>aa</label>Université Lille 2, Lille, France</aff><aff id="A28"><label>ab</label>Department of Neurology, University of California at Davis, Davis, California, USA</aff><aff id="A29"><label>ac</label>Department of Neuroepidemiology, INSERM U708, Bordeaux, France</aff><aff id="A30"><label>ad</label>Université Victor Segalen Bordeaux 2, France</aff><aff id="A31"><label>ae</label>Netherlands Consortium for Healthy Aging, Leiden, Netherlands</aff><aff id="A32"><label>af</label>Center for Medical Systems Biology, Leiden, Netherlands</aff><aff id="A33"><label>ag</label>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria</aff><aff id="A34"><label>ah</label>Departments of Neurology and Epidemiology, University of Washington, Seattle, Washington, USA</aff><aff id="A35"><label>ai</label>Department of Medicine-Geriatrics/Gerontology, University of Mississippi Medical Center, Jackson, Mississippi, USA</aff><aff id="A36"><label>aj</label>The Human Genetics Center and Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, USA</aff><aff id="A37"><label>ak</label>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA</aff><aff id="A38"><label>al</label>Department of Neurology, Lariboisière Hospital, Paris 7 University, DHU Neurovasc Paris Sorbonne, Paris, France</aff><aff id="A39"><label>am</label>University of Versailles Saint-Quentin-en-Yvelines, France</aff><author-notes><corresp id="FN1">Corresponding Author: Dr. Stéphanie Debette, MD, PhD, INSERM U740; 10 Avenue de Verdun; 75010 PARIS, Tel: +33 (0)6 84 07 72 53; Fax: +33 (0)1 57 27 85 94, <email>stephanie.debette@lrb.aphp.fr</email>; <email>sdebette@bu.edu</email></corresp><fn id="FN2" fn-type="equal"><label>*</label><p>These authors contributed equally to the manuscript</p></fn><fn id="FN3"><label>§</label><p>These authors jointly directed this work</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>06</day><month>1</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>4</month><year>2016</year></pub-date><volume>36</volume><issue>4</issue><fpage>1765.e7</fpage><lpage>1765.e16</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.neurobiolaging.2014.12.028</pmc-comment>
<permissions><copyright-statement>© 2015 Published by Elsevier Inc.</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><p id="P2">Whether novel risk variants of Alzheimer’s disease (AD) identified through genome-wide association studies (GWAS) also influence MRI-based intermediate phenotypes of AD in the general population is unclear. We studied association of 24 AD risk loci with intracranial volume (ICV), total brain volume (TBV), hippocampal volume (HV), white matter hyperintensity (WMH) burden, and brain infarcts in a meta-analysis of genetic association studies from large population-based samples (N=8,175–11,550). In single-SNP based tests, AD risk allele of <italic>APOE</italic> (rs2075650) was associated with smaller HV (p=0.0054) and <italic>CD33</italic> (rs3865444) with smaller ICV (p=0.0058) In gene-based tests, there was associations of <italic>HLA-DRB1</italic> with TBV (p=0.0006) and <italic>BIN1</italic> with HV (p=0.00089). A weighted AD genetic risk score was associated with smaller HV (beta±SE=−0.047±0.013, p=0.00041), even after excluding the <italic>APOE</italic> locus (p=0.029). However, only association of AD genetic risk score with HV, including <italic>APOE</italic>, was significant after multiple testing correction (including number of independent phenotypes tested). These results suggest that novel AD genetic risk variants may contribute to structural brain aging in non-demented older community persons.</p></abstract><kwd-group><kwd>Alzheimer</kwd><kwd>MRI-markers</kwd><kwd>genetic risk score</kwd><kwd>GWAS</kwd><kwd>hippocampal volume</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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