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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A large-scale genetic association study to evaluate the contribution of <italic>Omi/HtrA2</italic> (PARK13) to Parkinson’s disease</title><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation><nlm:aff id="A1">Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation><nlm:aff id="A1">Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Riess, Olaf" sort="Riess, Olaf" uniqKey="Riess O" first="Olaf" last="Riess">Olaf Riess</name><affiliation><nlm:aff id="A2">Medical Genetics, University of Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation><nlm:aff id="A1">Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation><nlm:aff id="A3">Laboratory of Neurogenetics, Insititute Born-Bunge, University of Antwerp, Antwerpen, Belgium</nlm:aff></affiliation></author><author><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name><affiliation><nlm:aff id="A3">Laboratory of Neurogenetics, Insititute Born-Bunge, University of Antwerp, Antwerpen, Belgium</nlm:aff></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation><nlm:aff id="A4">Department of Neurology, University of Trondheim, Norway</nlm:aff></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation><nlm:aff id="A5">Institute of Neurological Sciences, National Research Council, Cosenza, Italy</nlm:aff></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation><nlm:aff id="A6">Department of Neurology, Catholic University, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation><nlm:aff id="A7">Université Pierre et Marie Curie-Paris, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">INSERM, U975, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Cnrs, UMR 7225, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Djarmati, Ana" sort="Djarmati, Ana" uniqKey="Djarmati A" first="Ana" last="Djarmati">Ana Djarmati</name><affiliation><nlm:aff id="A11">Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation><nlm:aff id="A12">INSERM, Unit 708, F-75013, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A13">UPMC Univ Paris 06, U708, Neuroepidemiology, F-75005, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Farrer, Matthew" sort="Farrer, Matthew" uniqKey="Farrer M" first="Matthew" last="Farrer">Matthew Farrer</name><affiliation><nlm:aff id="A14">Department of Genetics, Mayo Clinic, Jacksonville, USA</nlm:aff></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation><nlm:aff id="A15">Department of Neuroscience, Section of Neurology, University of Milano-Bicocca San Gerardo Hospital, Monza, Italy</nlm:aff></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation><nlm:aff id="A16">The Dublin Neurological Institute at the Mater Misericordiae University Hospital, Clinical Investigator at the Conway Institute, University College Dublin, Ireland</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</nlm:aff></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation><nlm:aff id="A18">Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation><nlm:aff id="A20">Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation><nlm:aff id="A21">Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff></affiliation></author><author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation><nlm:aff id="A22">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation><nlm:aff id="A11">Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation><nlm:aff id="A32">INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245,1, rue du professeur Calmette, Lille cedex, France</nlm:aff></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation><nlm:aff id="A7">Université Pierre et Marie Curie-Paris, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">INSERM, U975, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Cnrs, UMR 7225, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Lin, Juei Jueng" sort="Lin, Juei Jueng" uniqKey="Lin J" first="Juei-Jueng" last="Lin">Juei-Jueng Lin</name><affiliation><nlm:aff id="A23">Department of Neurology, Chushang Show-Chwan Hospital, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation><nlm:aff id="A16">The Dublin Neurological Institute at the Mater Misericordiae University Hospital, Clinical Investigator at the Conway Institute, University College Dublin, Ireland</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</nlm:aff></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation><nlm:aff id="A24">Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A25">University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital, Australia</nlm:aff></affiliation></author><author><name sortKey="De Nigris, Francesa" sort="De Nigris, Francesa" uniqKey="De Nigris F" first="Francesa" last="De Nigris">Francesa De Nigris</name><affiliation><nlm:aff id="A6">Department of Neurology, Catholic University, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation><nlm:aff id="A22">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff></affiliation></author><author><name sortKey="Prigione, Alessandro" sort="Prigione, Alessandro" uniqKey="Prigione A" first="Alessandro" last="Prigione">Alessandro Prigione</name><affiliation><nlm:aff id="A15">Department of Neuroscience, Section of Neurology, University of Milano-Bicocca San Gerardo Hospital, Monza, Italy</nlm:aff></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><nlm:aff id="A26">Institute of Neurology, University Magna Graecia, Catanzaro, Italy</nlm:aff></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation><nlm:aff id="A14">Department of Genetics, Mayo Clinic, Jacksonville, USA</nlm:aff></affiliation></author><author><name sortKey="Satake, Wataru" sort="Satake, Wataru" uniqKey="Satake W" first="Wataru" last="Satake">Wataru Satake</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation><nlm:aff id="A24">Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A25">University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital, Australia</nlm:aff></affiliation></author><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng King" last="Tan">Eng King Tan</name><affiliation><nlm:aff id="A28">Department of Neurology, Singapore General Hospital, National Neuroscience Institute and Duke-NUS Graduate Medical School, Singapore</nlm:aff></affiliation></author><author><name sortKey="Toda, Tatsushi" sort="Toda, Tatsushi" uniqKey="Toda T" first="Tatsushi" last="Toda">Tatsushi Toda</name><affiliation><nlm:aff id="A27">Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Japan</nlm:aff></affiliation></author><author><name sortKey="Tomiyama, Hiroyuki" sort="Tomiyama, Hiroyuki" uniqKey="Tomiyama H" first="Hiroyuki" last="Tomiyama">Hiroyuki Tomiyama</name><affiliation><nlm:aff id="A20">Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation><nlm:aff id="A29">Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Wszolek, Zbigniew" sort="Wszolek, Zbigniew" uniqKey="Wszolek Z" first="Zbigniew" last="Wszolek">Zbigniew Wszolek</name><affiliation><nlm:aff id="A30">Department of Neurology, Mayo Clinic Jacksonville, USA</nlm:aff></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation><nlm:aff id="A18">Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation><nlm:aff id="A31">Department of Neurology, Mayo Clinic, Rochester, MN, United States</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20036034</idno><idno type="pmc">4724437</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724437</idno><idno type="RBID">PMC:4724437</idno><idno type="doi">10.1016/j.neurobiolaging.2009.11.021</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">001F95</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F95</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A large-scale genetic association study to evaluate the contribution of <italic>Omi/HtrA2</italic> (PARK13) to Parkinson’s disease</title><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation><nlm:aff id="A1">Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation><nlm:aff id="A1">Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Riess, Olaf" sort="Riess, Olaf" uniqKey="Riess O" first="Olaf" last="Riess">Olaf Riess</name><affiliation><nlm:aff id="A2">Medical Genetics, University of Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation><nlm:aff id="A1">Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation><nlm:aff id="A3">Laboratory of Neurogenetics, Insititute Born-Bunge, University of Antwerp, Antwerpen, Belgium</nlm:aff></affiliation></author><author><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name><affiliation><nlm:aff id="A3">Laboratory of Neurogenetics, Insititute Born-Bunge, University of Antwerp, Antwerpen, Belgium</nlm:aff></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation><nlm:aff id="A4">Department of Neurology, University of Trondheim, Norway</nlm:aff></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation><nlm:aff id="A5">Institute of Neurological Sciences, National Research Council, Cosenza, Italy</nlm:aff></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation><nlm:aff id="A6">Department of Neurology, Catholic University, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation><nlm:aff id="A7">Université Pierre et Marie Curie-Paris, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">INSERM, U975, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Cnrs, UMR 7225, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Djarmati, Ana" sort="Djarmati, Ana" uniqKey="Djarmati A" first="Ana" last="Djarmati">Ana Djarmati</name><affiliation><nlm:aff id="A11">Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation><nlm:aff id="A12">INSERM, Unit 708, F-75013, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A13">UPMC Univ Paris 06, U708, Neuroepidemiology, F-75005, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Farrer, Matthew" sort="Farrer, Matthew" uniqKey="Farrer M" first="Matthew" last="Farrer">Matthew Farrer</name><affiliation><nlm:aff id="A14">Department of Genetics, Mayo Clinic, Jacksonville, USA</nlm:aff></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation><nlm:aff id="A15">Department of Neuroscience, Section of Neurology, University of Milano-Bicocca San Gerardo Hospital, Monza, Italy</nlm:aff></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation><nlm:aff id="A16">The Dublin Neurological Institute at the Mater Misericordiae University Hospital, Clinical Investigator at the Conway Institute, University College Dublin, Ireland</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</nlm:aff></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation><nlm:aff id="A18">Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation><nlm:aff id="A20">Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation><nlm:aff id="A21">Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff></affiliation></author><author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation><nlm:aff id="A22">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation><nlm:aff id="A11">Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation><nlm:aff id="A32">INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245,1, rue du professeur Calmette, Lille cedex, France</nlm:aff></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation><nlm:aff id="A7">Université Pierre et Marie Curie-Paris, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">INSERM, U975, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Cnrs, UMR 7225, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A10">AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Lin, Juei Jueng" sort="Lin, Juei Jueng" uniqKey="Lin J" first="Juei-Jueng" last="Lin">Juei-Jueng Lin</name><affiliation><nlm:aff id="A23">Department of Neurology, Chushang Show-Chwan Hospital, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation><nlm:aff id="A16">The Dublin Neurological Institute at the Mater Misericordiae University Hospital, Clinical Investigator at the Conway Institute, University College Dublin, Ireland</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</nlm:aff></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation><nlm:aff id="A24">Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A25">University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital, Australia</nlm:aff></affiliation></author><author><name sortKey="De Nigris, Francesa" sort="De Nigris, Francesa" uniqKey="De Nigris F" first="Francesa" last="De Nigris">Francesa De Nigris</name><affiliation><nlm:aff id="A6">Department of Neurology, Catholic University, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation><nlm:aff id="A22">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff></affiliation></author><author><name sortKey="Prigione, Alessandro" sort="Prigione, Alessandro" uniqKey="Prigione A" first="Alessandro" last="Prigione">Alessandro Prigione</name><affiliation><nlm:aff id="A15">Department of Neuroscience, Section of Neurology, University of Milano-Bicocca San Gerardo Hospital, Monza, Italy</nlm:aff></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><nlm:aff id="A26">Institute of Neurology, University Magna Graecia, Catanzaro, Italy</nlm:aff></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation><nlm:aff id="A14">Department of Genetics, Mayo Clinic, Jacksonville, USA</nlm:aff></affiliation></author><author><name sortKey="Satake, Wataru" sort="Satake, Wataru" uniqKey="Satake W" first="Wataru" last="Satake">Wataru Satake</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation><nlm:aff id="A24">Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A25">University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital, Australia</nlm:aff></affiliation></author><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng King" last="Tan">Eng King Tan</name><affiliation><nlm:aff id="A28">Department of Neurology, Singapore General Hospital, National Neuroscience Institute and Duke-NUS Graduate Medical School, Singapore</nlm:aff></affiliation></author><author><name sortKey="Toda, Tatsushi" sort="Toda, Tatsushi" uniqKey="Toda T" first="Tatsushi" last="Toda">Tatsushi Toda</name><affiliation><nlm:aff id="A27">Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Japan</nlm:aff></affiliation></author><author><name sortKey="Tomiyama, Hiroyuki" sort="Tomiyama, Hiroyuki" uniqKey="Tomiyama H" first="Hiroyuki" last="Tomiyama">Hiroyuki Tomiyama</name><affiliation><nlm:aff id="A20">Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation><nlm:aff id="A29">Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Wszolek, Zbigniew" sort="Wszolek, Zbigniew" uniqKey="Wszolek Z" first="Zbigniew" last="Wszolek">Zbigniew Wszolek</name><affiliation><nlm:aff id="A30">Department of Neurology, Mayo Clinic Jacksonville, USA</nlm:aff></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation><nlm:aff id="A18">Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation><nlm:aff id="A31">Department of Neurology, Mayo Clinic, Rochester, MN, United States</nlm:aff></affiliation></author></analytic><series><title level="j">Neurobiology of aging</title><idno type="ISSN">0197-4580</idno><idno type="eISSN">1558-1497</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">High-profile studies have provided conflicting results regarding the involvement of the <italic>Omi/HtrA2</italic> gene in Parkinson’s disease (PD) susceptibility. Therefore, we performed a large-scale analysis of the association of common <italic>Omi/HtrA2</italic> variants in the Genetic Epidemiology of Parkinson’s disease (GEO-PD) consortium.</p><p id="P2">GEO-PD sites provided clinical and genetic data including affection status, gender, ethnicity, age at study, age at examination (all subjects); age at onset and family history of PD (patients). Genotyping was performed for the five most informative SNPs spanning the <italic>Omi/HtrA2</italic> gene in approximately 2–3 kb intervals (rs10779958, rs2231250, rs72470544, rs1183739, rs2241028). Fixed as well as random effect models were used to provide summary risk estimates of <italic>Omi/HtrA2</italic> variants.</p><p id="P3">The 20 GEO-PD sites provided data for 6378 cases and 8880 controls. No overall significant associations for the five <italic>Omi/HtrA2</italic> SNPs and PD were observed using either fixed effect or random effect models. The summary odds ratios ranged between 0.98 and 1.08 and the estimates of between-study heterogeneity were not large (non-significant <italic>Q</italic> statistics for all 5 SNPs; <italic>I</italic><sup>2</sup> estimates 0–28%). Trends for association were seen for participants of Scandinavian descent for rs2241028 (OR 1.41, <italic>p</italic> = 0.04) and for rs1183739 for age at examination (cut-off 65 years; OR 1.17, <italic>p</italic> = 0.02), but these would not be significant after adjusting for multiple comparisons and their Bayes factors were only modest.</p><p id="P4">This largest association study performed to define the role of any gene in the pathogenesis of Parkinson’s disease revealed no overall strong association of <italic>Omi/HtrA2</italic> variants with PD in populations worldwide.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8100437</journal-id><journal-id journal-id-type="pubmed-jr-id">6047</journal-id><journal-id journal-id-type="nlm-ta">Neurobiol Aging</journal-id><journal-id journal-id-type="iso-abbrev">Neurobiol. Aging</journal-id><journal-title-group><journal-title>Neurobiology of aging</journal-title></journal-title-group><issn pub-type="ppub">0197-4580</issn><issn pub-type="epub">1558-1497</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20036034</article-id><article-id pub-id-type="pmc">4724437</article-id><article-id pub-id-type="doi">10.1016/j.neurobiolaging.2009.11.021</article-id><article-id pub-id-type="manuscript">NIHMS751642</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A large-scale genetic association study to evaluate the contribution of <italic>Omi/HtrA2</italic> (PARK13) to Parkinson’s disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Krüger</surname><given-names>Rejko</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref rid="FN1" ref-type="author-notes">*</xref><xref rid="FN2" ref-type="author-notes">1</xref></contrib><contrib contrib-type="author"><name><surname>Sharma</surname><given-names>Manu</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref rid="FN2" ref-type="author-notes">1</xref></contrib><contrib contrib-type="author"><name><surname>Riess</surname><given-names>Olaf</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Gasser</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Van Broeckhoven</surname><given-names>Christine</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Theuns</surname><given-names>Jessie</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Aasly</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Annesi</surname><given-names>Grazia</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Bentivoglio</surname><given-names>Anna Rita</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Brice</surname><given-names>Alexis</given-names></name><xref ref-type="aff" rid="A7">g</xref><xref ref-type="aff" rid="A8">h</xref><xref ref-type="aff" rid="A9">i</xref><xref ref-type="aff" rid="A10">j</xref></contrib><contrib contrib-type="author"><name><surname>Djarmati</surname><given-names>Ana</given-names></name><xref ref-type="aff" rid="A11">k</xref></contrib><contrib contrib-type="author"><name><surname>Elbaz</surname><given-names>Alexis</given-names></name><xref ref-type="aff" rid="A12">l</xref><xref ref-type="aff" rid="A13">m</xref></contrib><contrib contrib-type="author"><name><surname>Farrer</surname><given-names>Matthew</given-names></name><xref ref-type="aff" rid="A14">n</xref></contrib><contrib contrib-type="author"><name><surname>Ferrarese</surname><given-names>Carlo</given-names></name><xref ref-type="aff" rid="A15">o</xref></contrib><contrib contrib-type="author"><name><surname>Gibson</surname><given-names>J. Mark</given-names></name><xref ref-type="aff" rid="A16">p</xref><xref ref-type="aff" rid="A17">q</xref></contrib><contrib contrib-type="author"><name><surname>Hadjigeorgiou</surname><given-names>Georgios M.</given-names></name><xref ref-type="aff" rid="A18">r</xref><xref ref-type="aff" rid="A19">s</xref></contrib><contrib contrib-type="author"><name><surname>Hattori</surname><given-names>Nobutaka</given-names></name><xref ref-type="aff" rid="A20">t</xref></contrib><contrib contrib-type="author"><name><surname>Ioannidis</surname><given-names>John P.A.</given-names></name><xref ref-type="aff" rid="A21">u</xref></contrib><contrib contrib-type="author"><name><surname>Jasinska-Myga</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="A22">v</xref></contrib><contrib contrib-type="author"><name><surname>Klein</surname><given-names>Christine</given-names></name><xref ref-type="aff" rid="A11">k</xref></contrib><contrib contrib-type="author"><name><surname>Lambert</surname><given-names>Jean-Charles</given-names></name><xref ref-type="aff" rid="A32">F</xref></contrib><contrib contrib-type="author"><name><surname>Lesage</surname><given-names>Suzanne</given-names></name><xref ref-type="aff" rid="A7">g</xref><xref ref-type="aff" rid="A8">h</xref><xref ref-type="aff" rid="A9">i</xref><xref ref-type="aff" rid="A10">j</xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Juei-Jueng</given-names></name><xref ref-type="aff" rid="A23">w</xref></contrib><contrib contrib-type="author"><name><surname>Lynch</surname><given-names>Timothy</given-names></name><xref ref-type="aff" rid="A16">p</xref><xref ref-type="aff" rid="A17">q</xref></contrib><contrib contrib-type="author"><name><surname>Mellick</surname><given-names>George D.</given-names></name><xref ref-type="aff" rid="A24">x</xref><xref ref-type="aff" rid="A25">y</xref></contrib><contrib contrib-type="author"><name><surname>de Nigris</surname><given-names>Francesa</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Opala</surname><given-names>Grzegorz</given-names></name><xref ref-type="aff" rid="A22">v</xref></contrib><contrib contrib-type="author"><name><surname>Prigione</surname><given-names>Alessandro</given-names></name><xref ref-type="aff" rid="A15">o</xref></contrib><contrib contrib-type="author"><name><surname>Quattrone</surname><given-names>Aldo</given-names></name><xref ref-type="aff" rid="A26">z</xref></contrib><contrib contrib-type="author"><name><surname>Ross</surname><given-names>Owen A.</given-names></name><xref ref-type="aff" rid="A14">n</xref></contrib><contrib contrib-type="author"><name><surname>Satake</surname><given-names>Wataru</given-names></name><xref ref-type="aff" rid="A1">A</xref></contrib><contrib contrib-type="author"><name><surname>Silburn</surname><given-names>Peter A.</given-names></name><xref ref-type="aff" rid="A24">x</xref><xref ref-type="aff" rid="A25">y</xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Eng King</given-names></name><xref ref-type="aff" rid="A28">B</xref></contrib><contrib contrib-type="author"><name><surname>Toda</surname><given-names>Tatsushi</given-names></name><xref ref-type="aff" rid="A27">A</xref></contrib><contrib contrib-type="author"><name><surname>Tomiyama</surname><given-names>Hiroyuki</given-names></name><xref ref-type="aff" rid="A20">t</xref><xref ref-type="aff" rid="A21">u</xref></contrib><contrib contrib-type="author"><name><surname>Wirdefeldt</surname><given-names>Karin</given-names></name><xref ref-type="aff" rid="A29">C</xref></contrib><contrib contrib-type="author"><name><surname>Wszolek</surname><given-names>Zbigniew</given-names></name><xref ref-type="aff" rid="A30">D</xref></contrib><contrib contrib-type="author"><name><surname>Xiromerisiou</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="A18">r</xref><xref ref-type="aff" rid="A19">s</xref></contrib><contrib contrib-type="author"><name><surname>Maraganore</surname><given-names>Demetrius M.</given-names></name><xref ref-type="aff" rid="A31">E</xref></contrib><on-behalf-of>for the Genetic Epidemiology of Parkinson’s disease consortium</on-behalf-of></contrib-group><aff id="A1"><label>a</label>Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany</aff><aff id="A2"><label>b</label>Medical Genetics, University of Tübingen, Germany</aff><aff id="A3"><label>c</label>Laboratory of Neurogenetics, Insititute Born-Bunge, University of Antwerp, Antwerpen, Belgium</aff><aff id="A4"><label>d</label>Department of Neurology, University of Trondheim, Norway</aff><aff id="A5"><label>e</label>Institute of Neurological Sciences, National Research Council, Cosenza, Italy</aff><aff id="A6"><label>f</label>Department of Neurology, Catholic University, Rome, Italy</aff><aff id="A7"><label>g</label>Université Pierre et Marie Curie-Paris, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France</aff><aff id="A8"><label>h</label>INSERM, U975, Paris, France</aff><aff id="A9"><label>i</label>Cnrs, UMR 7225, Paris, France</aff><aff id="A10"><label>j</label>AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris, France</aff><aff id="A11"><label>k</label>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Germany</aff><aff id="A12"><label>l</label>INSERM, Unit 708, F-75013, Paris, France</aff><aff id="A13"><label>m</label>UPMC Univ Paris 06, U708, Neuroepidemiology, F-75005, Paris, France</aff><aff id="A14"><label>n</label>Department of Genetics, Mayo Clinic, Jacksonville, USA</aff><aff id="A15"><label>o</label>Department of Neuroscience, Section of Neurology, University of Milano-Bicocca San Gerardo Hospital, Monza, Italy</aff><aff id="A16"><label>p</label>The Dublin Neurological Institute at the Mater Misericordiae University Hospital, Clinical Investigator at the Conway Institute, University College Dublin, Ireland</aff><aff id="A17"><label>q</label>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</aff><aff id="A18"><label>r</label>Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa, Greece</aff><aff id="A19"><label>s</label>Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</aff><aff id="A20"><label>t</label>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan</aff><aff id="A21"><label>u</label>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</aff><aff id="A22"><label>v</label>Department of Neurology, Medical University of Silesia, Katowice, Poland</aff><aff id="A23"><label>w</label>Department of Neurology, Chushang Show-Chwan Hospital, Taiwan</aff><aff id="A24"><label>x</label>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD, Australia</aff><aff id="A25"><label>y</label>University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital, Australia</aff><aff id="A26"><label>z</label>Institute of Neurology, University Magna Graecia, Catanzaro, Italy</aff><aff id="A27"><label>A</label>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Japan</aff><aff id="A28"><label>B</label>Department of Neurology, Singapore General Hospital, National Neuroscience Institute and Duke-NUS Graduate Medical School, Singapore</aff><aff id="A29"><label>C</label>Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A30"><label>D</label>Department of Neurology, Mayo Clinic Jacksonville, USA</aff><aff id="A31"><label>E</label>Department of Neurology, Mayo Clinic, Rochester, MN, United States</aff><aff id="A32"><label>F</label>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245,1, rue du professeur Calmette, Lille cedex, France</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author at: Laboratory of Functional Neurogenomics, Center of Neurology and Hertie-Institute of Clinical Brain Research, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany. Tel.: +49 7071 2982340; fax: +49 7071 295260. <email>rejko.krueger@uni-tuebingen.de</email> (R. Krüger)</corresp><fn id="FN2" fn-type="equal"><label>1</label><p>These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>16</day><month>1</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>24</day><month>12</month><year>2009</year></pub-date><pub-date pub-type="ppub"><month>3</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>24</day><month>1</month><year>2016</year></pub-date><volume>32</volume><issue>3</issue><fpage>548.e9</fpage><lpage>548.18</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.neurobiolaging.2009.11.021</pmc-comment>
<abstract><p id="P1">High-profile studies have provided conflicting results regarding the involvement of the <italic>Omi/HtrA2</italic> gene in Parkinson’s disease (PD) susceptibility. Therefore, we performed a large-scale analysis of the association of common <italic>Omi/HtrA2</italic> variants in the Genetic Epidemiology of Parkinson’s disease (GEO-PD) consortium.</p><p id="P2">GEO-PD sites provided clinical and genetic data including affection status, gender, ethnicity, age at study, age at examination (all subjects); age at onset and family history of PD (patients). Genotyping was performed for the five most informative SNPs spanning the <italic>Omi/HtrA2</italic> gene in approximately 2–3 kb intervals (rs10779958, rs2231250, rs72470544, rs1183739, rs2241028). Fixed as well as random effect models were used to provide summary risk estimates of <italic>Omi/HtrA2</italic> variants.</p><p id="P3">The 20 GEO-PD sites provided data for 6378 cases and 8880 controls. No overall significant associations for the five <italic>Omi/HtrA2</italic> SNPs and PD were observed using either fixed effect or random effect models. The summary odds ratios ranged between 0.98 and 1.08 and the estimates of between-study heterogeneity were not large (non-significant <italic>Q</italic> statistics for all 5 SNPs; <italic>I</italic><sup>2</sup> estimates 0–28%). Trends for association were seen for participants of Scandinavian descent for rs2241028 (OR 1.41, <italic>p</italic> = 0.04) and for rs1183739 for age at examination (cut-off 65 years; OR 1.17, <italic>p</italic> = 0.02), but these would not be significant after adjusting for multiple comparisons and their Bayes factors were only modest.</p><p id="P4">This largest association study performed to define the role of any gene in the pathogenesis of Parkinson’s disease revealed no overall strong association of <italic>Omi/HtrA2</italic> variants with PD in populations worldwide.</p></abstract><kwd-group><kwd>Omi</kwd><kwd>HtrA2</kwd><kwd>Genetics</kwd><kwd>Parkinson’s disease</kwd><kwd>PARK13</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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