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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical MRSA isolates from skin and soft tissue infections show increased <italic>in vitro</italic> production of phenol soluble modulins</title><author><name sortKey="Berlon, Nicholas R" sort="Berlon, Nicholas R" uniqKey="Berlon N" first="Nicholas R." last="Berlon">Nicholas R. Berlon</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Qi, Robert" sort="Qi, Robert" uniqKey="Qi R" first="Robert" last="Qi">Robert Qi</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Sharma Kuinkel, Batu K" sort="Sharma Kuinkel, Batu K" uniqKey="Sharma Kuinkel B" first="Batu K." last="Sharma-Kuinkel">Batu K. Sharma-Kuinkel</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Joo, Hwang Soo" sort="Joo, Hwang Soo" uniqKey="Joo H" first="Hwang-Soo" last="Joo">Hwang-Soo Joo</name><affiliation><nlm:aff id="A2">National Institutes of Health, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Park, Lawrence P" sort="Park, Lawrence P" uniqKey="Park L" first="Lawrence P." last="Park">Lawrence P. Park</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="George, Dennis" sort="George, Dennis" uniqKey="George D" first="Dennis" last="George">Dennis George</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Thaden, Joshua T" sort="Thaden, Joshua T" uniqKey="Thaden J" first="Joshua T." last="Thaden">Joshua T. Thaden</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Messina, Julia A" sort="Messina, Julia A" uniqKey="Messina J" first="Julia A." last="Messina">Julia A. Messina</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Maskarinec, Stacey A" sort="Maskarinec, Stacey A" uniqKey="Maskarinec S" first="Stacey A." last="Maskarinec">Stacey A. Maskarinec</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Mueller Premru, Manica" sort="Mueller Premru, Manica" uniqKey="Mueller Premru M" first="Manica" last="Mueller-Premru">Manica Mueller-Premru</name><affiliation><nlm:aff id="A3">University of Ljubljana, Ljubljana, Slovenia</nlm:aff></affiliation></author><author><name sortKey="Athan, Eugene" sort="Athan, Eugene" uniqKey="Athan E" first="Eugene" last="Athan">Eugene Athan</name><affiliation><nlm:aff id="A4">Barwon Health, Deakin University, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Tattevin, Pierre" sort="Tattevin, Pierre" uniqKey="Tattevin P" first="Pierre" last="Tattevin">Pierre Tattevin</name><affiliation><nlm:aff id="A5">Pontchaillou University, Pontchaillou, France</nlm:aff></affiliation></author><author><name sortKey="Pericas, Juan M" sort="Pericas, Juan M" uniqKey="Pericas J" first="Juan M." last="Pericas">Juan M. Pericas</name><affiliation><nlm:aff id="A6">Hospital Clinic – IDIBAPS. Univ. Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Woods, Christopher W" sort="Woods, Christopher W" uniqKey="Woods C" first="Christopher W." last="Woods">Christopher W. Woods</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Otto, Michael" sort="Otto, Michael" uniqKey="Otto M" first="Michael" last="Otto">Michael Otto</name><affiliation><nlm:aff id="A2">National Institutes of Health, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Fowler, Vance G" sort="Fowler, Vance G" uniqKey="Fowler V" first="Vance G." last="Fowler">Vance G. Fowler</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26079275</idno><idno type="pmc">4816458</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816458</idno><idno type="RBID">PMC:4816458</idno><idno type="doi">10.1016/j.jinf.2015.06.005</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001F86</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F86</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical MRSA isolates from skin and soft tissue infections show increased <italic>in vitro</italic> production of phenol soluble modulins</title><author><name sortKey="Berlon, Nicholas R" sort="Berlon, Nicholas R" uniqKey="Berlon N" first="Nicholas R." last="Berlon">Nicholas R. Berlon</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Qi, Robert" sort="Qi, Robert" uniqKey="Qi R" first="Robert" last="Qi">Robert Qi</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Sharma Kuinkel, Batu K" sort="Sharma Kuinkel, Batu K" uniqKey="Sharma Kuinkel B" first="Batu K." last="Sharma-Kuinkel">Batu K. Sharma-Kuinkel</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Joo, Hwang Soo" sort="Joo, Hwang Soo" uniqKey="Joo H" first="Hwang-Soo" last="Joo">Hwang-Soo Joo</name><affiliation><nlm:aff id="A2">National Institutes of Health, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Park, Lawrence P" sort="Park, Lawrence P" uniqKey="Park L" first="Lawrence P." last="Park">Lawrence P. Park</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="George, Dennis" sort="George, Dennis" uniqKey="George D" first="Dennis" last="George">Dennis George</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Thaden, Joshua T" sort="Thaden, Joshua T" uniqKey="Thaden J" first="Joshua T." last="Thaden">Joshua T. Thaden</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Messina, Julia A" sort="Messina, Julia A" uniqKey="Messina J" first="Julia A." last="Messina">Julia A. Messina</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Maskarinec, Stacey A" sort="Maskarinec, Stacey A" uniqKey="Maskarinec S" first="Stacey A." last="Maskarinec">Stacey A. Maskarinec</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Mueller Premru, Manica" sort="Mueller Premru, Manica" uniqKey="Mueller Premru M" first="Manica" last="Mueller-Premru">Manica Mueller-Premru</name><affiliation><nlm:aff id="A3">University of Ljubljana, Ljubljana, Slovenia</nlm:aff></affiliation></author><author><name sortKey="Athan, Eugene" sort="Athan, Eugene" uniqKey="Athan E" first="Eugene" last="Athan">Eugene Athan</name><affiliation><nlm:aff id="A4">Barwon Health, Deakin University, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Tattevin, Pierre" sort="Tattevin, Pierre" uniqKey="Tattevin P" first="Pierre" last="Tattevin">Pierre Tattevin</name><affiliation><nlm:aff id="A5">Pontchaillou University, Pontchaillou, France</nlm:aff></affiliation></author><author><name sortKey="Pericas, Juan M" sort="Pericas, Juan M" uniqKey="Pericas J" first="Juan M." last="Pericas">Juan M. Pericas</name><affiliation><nlm:aff id="A6">Hospital Clinic – IDIBAPS. Univ. Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Woods, Christopher W" sort="Woods, Christopher W" uniqKey="Woods C" first="Christopher W." last="Woods">Christopher W. Woods</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Otto, Michael" sort="Otto, Michael" uniqKey="Otto M" first="Michael" last="Otto">Michael Otto</name><affiliation><nlm:aff id="A2">National Institutes of Health, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Fowler, Vance G" sort="Fowler, Vance G" uniqKey="Fowler V" first="Vance G." last="Fowler">Vance G. Fowler</name><affiliation><nlm:aff id="A1">Duke U Med Center, NC, USA</nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of infection</title><idno type="ISSN">0163-4453</idno><idno type="eISSN">1532-2742</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><sec id="S1"><title>Background</title><p id="P1">Phenol-soluble modulins (PSMs) are amphipathic, pro-inflammatory proteins secreted by most <italic>Staphylococcus aureus</italic> isolates. This study tested the hypothesis that <italic>in vitro</italic> PSM production levels are associated with specific clinical phenotypes.</p></sec><sec id="S2"><title>Methods</title><p id="P2">177 methicillin-resistant <italic>S. aureus</italic> (MRSA) isolates from infective endocarditis (IE), skin and soft tissue infection (SSTI), and hospital-acquired/ventilator-associated pneumonia (HAP) were matched by geographic origin, then genotyped using <italic>spa</italic>-typing. <italic>In vitro</italic> PSM production was measured by high performance liquid chromatography/mass spectrometry. Statistical analysis was performed using Chi-squared or Kruskal–Wallis tests as appropriate.</p></sec><sec id="S3"><title>Results</title><p id="P3"><italic>Spa</italic> type 1 was significantly more common in SSTI isolates (62.7% SSTI; 1.7% IE; 16.9% HAP; p < 0.0001) while HAP and IE isolates were more commonly <italic>spa</italic> type 2 (0% SSTI; 37.3% IE; 40.7% HAP; p < 0.0001). USA300 isolates produced the highest levels of PSMs <italic>in vitro</italic>. SSTI isolates produced significantly higher quantities of PSMα1-4, PSMβ1, and δ-toxin than other isolates (p < 0.001). These findings persisted when USA300 isolates were excluded from analysis.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7908424</journal-id><journal-id journal-id-type="pubmed-jr-id">4825</journal-id><journal-id journal-id-type="nlm-ta">J Infect</journal-id><journal-id journal-id-type="iso-abbrev">J. Infect.</journal-id><journal-title-group><journal-title>The Journal of infection</journal-title></journal-title-group><issn pub-type="ppub">0163-4453</issn><issn pub-type="epub">1532-2742</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26079275</article-id><article-id pub-id-type="pmc">4816458</article-id><article-id pub-id-type="doi">10.1016/j.jinf.2015.06.005</article-id><article-id pub-id-type="manuscript">NIHMS767691</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Clinical MRSA isolates from skin and soft tissue infections show increased <italic>in vitro</italic> production of phenol soluble modulins</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Berlon</surname><given-names>Nicholas R.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Qi</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Sharma-Kuinkel</surname><given-names>Batu K.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Joo</surname><given-names>Hwang-Soo</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Lawrence P.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>George</surname><given-names>Dennis</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Thaden</surname><given-names>Joshua T.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Messina</surname><given-names>Julia A.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Maskarinec</surname><given-names>Stacey A.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Mueller-Premru</surname><given-names>Manica</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Athan</surname><given-names>Eugene</given-names></name><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Tattevin</surname><given-names>Pierre</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Pericas</surname><given-names>Juan M.</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Woods</surname><given-names>Christopher W.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Otto</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Fowler</surname><given-names>Vance G.</given-names><suffix>Jr.</suffix></name><xref ref-type="aff" rid="A1">a</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>a</label>Duke U Med Center, NC, USA</aff><aff id="A2"><label>b</label>National Institutes of Health, MD, USA</aff><aff id="A3"><label>c</label>University of Ljubljana, Ljubljana, Slovenia</aff><aff id="A4"><label>d</label>Barwon Health, Deakin University, VIC, Australia</aff><aff id="A5"><label>e</label>Pontchaillou University, Pontchaillou, France</aff><aff id="A6"><label>f</label>Hospital Clinic – IDIBAPS. Univ. Barcelona, Spain</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author. Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Box 102359, Durham, NC 27710, USA. Tel.: +1 (919) 613 5678; fax: +1 (919) 684 8902. <email>fowle003@mc.duke.edu</email> (V.G. Fowler)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>15</day><month>3</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>14</day><month>6</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>31</day><month>3</month><year>2016</year></pub-date><volume>71</volume><issue>4</issue><fpage>447</fpage><lpage>457</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.jinf.2015.06.005</pmc-comment>
<abstract><title>Summary</title><sec id="S1"><title>Background</title><p id="P1">Phenol-soluble modulins (PSMs) are amphipathic, pro-inflammatory proteins secreted by most <italic>Staphylococcus aureus</italic> isolates. This study tested the hypothesis that <italic>in vitro</italic> PSM production levels are associated with specific clinical phenotypes.</p></sec><sec id="S2"><title>Methods</title><p id="P2">177 methicillin-resistant <italic>S. aureus</italic> (MRSA) isolates from infective endocarditis (IE), skin and soft tissue infection (SSTI), and hospital-acquired/ventilator-associated pneumonia (HAP) were matched by geographic origin, then genotyped using <italic>spa</italic>-typing. <italic>In vitro</italic> PSM production was measured by high performance liquid chromatography/mass spectrometry. Statistical analysis was performed using Chi-squared or Kruskal–Wallis tests as appropriate.</p></sec><sec id="S3"><title>Results</title><p id="P3"><italic>Spa</italic> type 1 was significantly more common in SSTI isolates (62.7% SSTI; 1.7% IE; 16.9% HAP; p < 0.0001) while HAP and IE isolates were more commonly <italic>spa</italic> type 2 (0% SSTI; 37.3% IE; 40.7% HAP; p < 0.0001). USA300 isolates produced the highest levels of PSMs <italic>in vitro</italic>. SSTI isolates produced significantly higher quantities of PSMα1-4, PSMβ1, and δ-toxin than other isolates (p < 0.001). These findings persisted when USA300 isolates were excluded from analysis.</p></sec></abstract><kwd-group><kwd>Phenol soluble modulin</kwd><kwd>MRSA</kwd><kwd>Skin and soft tissue infection</kwd><kwd>Pneumonia</kwd><kwd>Endocarditis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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