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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Phyllodes tumours of the breast: a consensus review</title><author><name sortKey="Tan, Benjamin Y" sort="Tan, Benjamin Y" uniqKey="Tan B" first="Benjamin Y" last="Tan">Benjamin Y. Tan</name></author><author><name sortKey="Acs, Geza" sort="Acs, Geza" uniqKey="Acs G" first="Geza" last="Acs">Geza Acs</name><affiliation><nlm:aff id="A2">Women’s Pathology Consultants, Ruffolo Hooper & Associates, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Apple, Sophia K" sort="Apple, Sophia K" uniqKey="Apple S" first="Sophia K" last="Apple">Sophia K. Apple</name><affiliation><nlm:aff id="A3">Department of Pathology, UCLA Medical Center, Santa Monica, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Badve, Sunil" sort="Badve, Sunil" uniqKey="Badve S" first="Sunil" last="Badve">Sunil Badve</name><affiliation><nlm:aff id="A4">Departments of Pathology and Internal Medicine, Clarian Pathology Laboratory of Indiana University, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Bleiweiss, Ira J" sort="Bleiweiss, Ira J" uniqKey="Bleiweiss I" first="Ira J" last="Bleiweiss">Ira J. Bleiweiss</name><affiliation><nlm:aff id="A5">Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Brogi, Edi" sort="Brogi, Edi" uniqKey="Brogi E" first="Edi" last="Brogi">Edi Brogi</name><affiliation><nlm:aff id="A6">Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Calvo, Jose P" sort="Calvo, Jose P" uniqKey="Calvo J" first="José P" last="Calvo">José P. Calvo</name><affiliation><nlm:aff id="A7">Servicio de Anatomía Patológica, Hospital Universitario Ramón y Cajal, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Dabbs, David J" sort="Dabbs, David J" uniqKey="Dabbs D" first="David J" last="Dabbs">David J. Dabbs</name><affiliation><nlm:aff id="A8">University of Pittsburgh Medical Center, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Ellis, Ian O" sort="Ellis, Ian O" uniqKey="Ellis I" first="Ian O" last="Ellis">Ian O. Ellis</name><affiliation><nlm:aff id="A9">Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK</nlm:aff></affiliation></author><author><name sortKey="Eusebi, Vincenzo" sort="Eusebi, Vincenzo" uniqKey="Eusebi V" first="Vincenzo" last="Eusebi">Vincenzo Eusebi</name><affiliation><nlm:aff id="A10">Sezione Anatomia e Istologia Patologica, ‘M. Malpighi’ Università di Bologna, Bologna, Italy</nlm:aff></affiliation></author><author><name sortKey="Farshid, Gelareh" sort="Farshid, Gelareh" uniqKey="Farshid G" first="Gelareh" last="Farshid">Gelareh Farshid</name><affiliation><nlm:aff id="A11">BreastScreen SA, Discipline of Medicine, Adelaide University and Directorate of Surgical Pathology, SA Pathology, Adelaide, South Australia</nlm:aff></affiliation></author><author><name sortKey="Fox, Stephen B" sort="Fox, Stephen B" uniqKey="Fox S" first="Stephen B" last="Fox">Stephen B. Fox</name><affiliation><nlm:aff id="A12">Pathology Department, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Vic., Australia</nlm:aff></affiliation></author><author><name sortKey="Ichihara, Shu" sort="Ichihara, Shu" uniqKey="Ichihara S" first="Shu" last="Ichihara">Shu Ichihara</name><affiliation><nlm:aff id="A13">Department of Pathology, Nagoya Medical Center, Nagoya, Japan</nlm:aff></affiliation></author><author><name sortKey="Lakhani, Sunil R" sort="Lakhani, Sunil R" uniqKey="Lakhani S" first="Sunil R" last="Lakhani">Sunil R. Lakhani</name><affiliation><nlm:aff id="A14">School of Medicine and Pathology Queensland, The Royal Brisbane & Women’s Hospital, University of Queensland Centre for Clinical Research, Brisbane, Qld, Australia</nlm:aff></affiliation></author><author><name sortKey="Rakha, Emad A" sort="Rakha, Emad A" uniqKey="Rakha E" first="Emad A" last="Rakha">Emad A. Rakha</name><affiliation><nlm:aff id="A9">Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK</nlm:aff></affiliation></author><author><name sortKey="Reis Filho, Jorge S" sort="Reis Filho, Jorge S" uniqKey="Reis Filho J" first="Jorge S" last="Reis-Filho">Jorge S. Reis-Filho</name><affiliation><nlm:aff id="A6">Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Richardson, Andrea L" sort="Richardson, Andrea L" uniqKey="Richardson A" first="Andrea L" last="Richardson">Andrea L. Richardson</name><affiliation><nlm:aff id="A15">Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Sahin, Aysegul" sort="Sahin, Aysegul" uniqKey="Sahin A" first="Aysegul" last="Sahin">Aysegul Sahin</name><affiliation><nlm:aff id="A16">Department of Pathology, Division of Pathology/Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Schmitt, Fernando C" sort="Schmitt, Fernando C" uniqKey="Schmitt F" first="Fernando C" last="Schmitt">Fernando C. Schmitt</name><affiliation><nlm:aff id="A17">Laboratoire national de santé, Luxembourg city, Luxembourg</nlm:aff></affiliation></author><author><name sortKey="Schnitt, Stuart J" sort="Schnitt, Stuart J" uniqKey="Schnitt S" first="Stuart J" last="Schnitt">Stuart J. Schnitt</name><affiliation><nlm:aff id="A18">Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Siziopikou, Kalliopi P" sort="Siziopikou, Kalliopi P" uniqKey="Siziopikou K" first="Kalliopi P" last="Siziopikou">Kalliopi P. Siziopikou</name><affiliation><nlm:aff id="A19">Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Soares, Fernando A" sort="Soares, Fernando A" uniqKey="Soares F" first="Fernando A" last="Soares">Fernando A. Soares</name><affiliation><nlm:aff id="A20">Department of Anatomic Pathology, A. C. Camargo Cancer Centre, São Paulo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Tse, Gary M" sort="Tse, Gary M" uniqKey="Tse G" first="Gary M" last="Tse">Gary M. Tse</name><affiliation><nlm:aff id="A21">Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Vincent Salomon, Anne" sort="Vincent Salomon, Anne" uniqKey="Vincent Salomon A" first="Anne" last="Vincent-Salomon">Anne Vincent-Salomon</name><affiliation><nlm:aff id="A22">Pôle Pathologie-Génétique-Immunologie, Institut Curie, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Tan, Puay Hoon" sort="Tan, Puay Hoon" uniqKey="Tan P" first="Puay Hoon" last="Tan">Puay Hoon Tan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26768026</idno><idno type="pmc">5027876</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027876</idno><idno type="RBID">PMC:5027876</idno><idno type="doi">10.1111/his.12876</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001F74</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F74</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Phyllodes tumours of the breast: a consensus review</title><author><name sortKey="Tan, Benjamin Y" sort="Tan, Benjamin Y" uniqKey="Tan B" first="Benjamin Y" last="Tan">Benjamin Y. Tan</name></author><author><name sortKey="Acs, Geza" sort="Acs, Geza" uniqKey="Acs G" first="Geza" last="Acs">Geza Acs</name><affiliation><nlm:aff id="A2">Women’s Pathology Consultants, Ruffolo Hooper & Associates, Tampa, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Apple, Sophia K" sort="Apple, Sophia K" uniqKey="Apple S" first="Sophia K" last="Apple">Sophia K. Apple</name><affiliation><nlm:aff id="A3">Department of Pathology, UCLA Medical Center, Santa Monica, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Badve, Sunil" sort="Badve, Sunil" uniqKey="Badve S" first="Sunil" last="Badve">Sunil Badve</name><affiliation><nlm:aff id="A4">Departments of Pathology and Internal Medicine, Clarian Pathology Laboratory of Indiana University, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Bleiweiss, Ira J" sort="Bleiweiss, Ira J" uniqKey="Bleiweiss I" first="Ira J" last="Bleiweiss">Ira J. Bleiweiss</name><affiliation><nlm:aff id="A5">Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Brogi, Edi" sort="Brogi, Edi" uniqKey="Brogi E" first="Edi" last="Brogi">Edi Brogi</name><affiliation><nlm:aff id="A6">Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Calvo, Jose P" sort="Calvo, Jose P" uniqKey="Calvo J" first="José P" last="Calvo">José P. Calvo</name><affiliation><nlm:aff id="A7">Servicio de Anatomía Patológica, Hospital Universitario Ramón y Cajal, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Dabbs, David J" sort="Dabbs, David J" uniqKey="Dabbs D" first="David J" last="Dabbs">David J. Dabbs</name><affiliation><nlm:aff id="A8">University of Pittsburgh Medical Center, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Ellis, Ian O" sort="Ellis, Ian O" uniqKey="Ellis I" first="Ian O" last="Ellis">Ian O. Ellis</name><affiliation><nlm:aff id="A9">Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK</nlm:aff></affiliation></author><author><name sortKey="Eusebi, Vincenzo" sort="Eusebi, Vincenzo" uniqKey="Eusebi V" first="Vincenzo" last="Eusebi">Vincenzo Eusebi</name><affiliation><nlm:aff id="A10">Sezione Anatomia e Istologia Patologica, ‘M. Malpighi’ Università di Bologna, Bologna, Italy</nlm:aff></affiliation></author><author><name sortKey="Farshid, Gelareh" sort="Farshid, Gelareh" uniqKey="Farshid G" first="Gelareh" last="Farshid">Gelareh Farshid</name><affiliation><nlm:aff id="A11">BreastScreen SA, Discipline of Medicine, Adelaide University and Directorate of Surgical Pathology, SA Pathology, Adelaide, South Australia</nlm:aff></affiliation></author><author><name sortKey="Fox, Stephen B" sort="Fox, Stephen B" uniqKey="Fox S" first="Stephen B" last="Fox">Stephen B. Fox</name><affiliation><nlm:aff id="A12">Pathology Department, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Vic., Australia</nlm:aff></affiliation></author><author><name sortKey="Ichihara, Shu" sort="Ichihara, Shu" uniqKey="Ichihara S" first="Shu" last="Ichihara">Shu Ichihara</name><affiliation><nlm:aff id="A13">Department of Pathology, Nagoya Medical Center, Nagoya, Japan</nlm:aff></affiliation></author><author><name sortKey="Lakhani, Sunil R" sort="Lakhani, Sunil R" uniqKey="Lakhani S" first="Sunil R" last="Lakhani">Sunil R. Lakhani</name><affiliation><nlm:aff id="A14">School of Medicine and Pathology Queensland, The Royal Brisbane & Women’s Hospital, University of Queensland Centre for Clinical Research, Brisbane, Qld, Australia</nlm:aff></affiliation></author><author><name sortKey="Rakha, Emad A" sort="Rakha, Emad A" uniqKey="Rakha E" first="Emad A" last="Rakha">Emad A. Rakha</name><affiliation><nlm:aff id="A9">Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK</nlm:aff></affiliation></author><author><name sortKey="Reis Filho, Jorge S" sort="Reis Filho, Jorge S" uniqKey="Reis Filho J" first="Jorge S" last="Reis-Filho">Jorge S. Reis-Filho</name><affiliation><nlm:aff id="A6">Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Richardson, Andrea L" sort="Richardson, Andrea L" uniqKey="Richardson A" first="Andrea L" last="Richardson">Andrea L. Richardson</name><affiliation><nlm:aff id="A15">Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Sahin, Aysegul" sort="Sahin, Aysegul" uniqKey="Sahin A" first="Aysegul" last="Sahin">Aysegul Sahin</name><affiliation><nlm:aff id="A16">Department of Pathology, Division of Pathology/Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Schmitt, Fernando C" sort="Schmitt, Fernando C" uniqKey="Schmitt F" first="Fernando C" last="Schmitt">Fernando C. Schmitt</name><affiliation><nlm:aff id="A17">Laboratoire national de santé, Luxembourg city, Luxembourg</nlm:aff></affiliation></author><author><name sortKey="Schnitt, Stuart J" sort="Schnitt, Stuart J" uniqKey="Schnitt S" first="Stuart J" last="Schnitt">Stuart J. Schnitt</name><affiliation><nlm:aff id="A18">Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Siziopikou, Kalliopi P" sort="Siziopikou, Kalliopi P" uniqKey="Siziopikou K" first="Kalliopi P" last="Siziopikou">Kalliopi P. Siziopikou</name><affiliation><nlm:aff id="A19">Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Soares, Fernando A" sort="Soares, Fernando A" uniqKey="Soares F" first="Fernando A" last="Soares">Fernando A. Soares</name><affiliation><nlm:aff id="A20">Department of Anatomic Pathology, A. C. Camargo Cancer Centre, São Paulo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Tse, Gary M" sort="Tse, Gary M" uniqKey="Tse G" first="Gary M" last="Tse">Gary M. Tse</name><affiliation><nlm:aff id="A21">Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Vincent Salomon, Anne" sort="Vincent Salomon, Anne" uniqKey="Vincent Salomon A" first="Anne" last="Vincent-Salomon">Anne Vincent-Salomon</name><affiliation><nlm:aff id="A22">Pôle Pathologie-Génétique-Immunologie, Institut Curie, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Tan, Puay Hoon" sort="Tan, Puay Hoon" uniqKey="Tan P" first="Puay Hoon" last="Tan">Puay Hoon Tan</name></author></analytic><series><title level="j">Histopathology</title><idno type="ISSN">0309-0167</idno><idno type="eISSN">1365-2559</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Phyllodes tumours constitute an uncommon but complex group of mammary fibroepithelial lesions. Accurate and reproducible grading of these tumours has long been challenging, owing to the need to assess multiple stratified histological parameters, which may be weighted differently by individual pathologists. Distinction of benign phyllodes tumours from cellular fibroadenomas is fraught with difficulty, due to overlapping microscopic features. Similarly, separation of the malignant phyllodes tumour from spindle cell metaplastic carcinoma and primary breast sarcoma can be problematic. Phyllodes tumours are treated by surgical excision. However, there is no consensus on the definition of an appropriate surgical margin to ensure completeness of excision and reduction of recurrence risk. Interpretive subjectivity, overlapping histological diagnostic criteria, suboptimal correlation between histological classification and clinical behaviour and the lack of robust molecular predictors of outcome make further investigation of the pathogenesis of these fascinating tumours a matter of active research. This review consolidates the current understanding of their pathobiology and clinical behaviour, and includes proposals for a rational approach to the classification and management of phyllodes tumours.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7704136</journal-id><journal-id journal-id-type="pubmed-jr-id">4076</journal-id><journal-id journal-id-type="nlm-ta">Histopathology</journal-id><journal-id journal-id-type="iso-abbrev">Histopathology</journal-id><journal-title-group><journal-title>Histopathology</journal-title></journal-title-group><issn pub-type="ppub">0309-0167</issn><issn pub-type="epub">1365-2559</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26768026</article-id><article-id pub-id-type="pmc">5027876</article-id><article-id pub-id-type="doi">10.1111/his.12876</article-id><article-id pub-id-type="manuscript">NIHMS804413</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Phyllodes tumours of the breast: a consensus review</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Benjamin Y</given-names></name></contrib><contrib contrib-type="author"><name><surname>Acs</surname><given-names>Geza</given-names></name><xref ref-type="aff" rid="A2">1</xref></contrib><contrib contrib-type="author"><name><surname>Apple</surname><given-names>Sophia K</given-names></name><xref ref-type="aff" rid="A3">2</xref></contrib><contrib contrib-type="author"><name><surname>Badve</surname><given-names>Sunil</given-names></name><xref ref-type="aff" rid="A4">3</xref></contrib><contrib contrib-type="author"><name><surname>Bleiweiss</surname><given-names>Ira J</given-names></name><xref ref-type="aff" rid="A5">4</xref></contrib><contrib contrib-type="author"><name><surname>Brogi</surname><given-names>Edi</given-names></name><xref ref-type="aff" rid="A6">5</xref></contrib><contrib contrib-type="author"><name><surname>Calvo</surname><given-names>José P</given-names></name><xref ref-type="aff" rid="A7">6</xref></contrib><contrib contrib-type="author"><name><surname>Dabbs</surname><given-names>David J</given-names></name><xref ref-type="aff" rid="A8">7</xref></contrib><contrib contrib-type="author"><name><surname>Ellis</surname><given-names>Ian O</given-names></name><xref ref-type="aff" rid="A9">8</xref></contrib><contrib contrib-type="author"><name><surname>Eusebi</surname><given-names>Vincenzo</given-names></name><xref ref-type="aff" rid="A10">9</xref></contrib><contrib contrib-type="author"><name><surname>Farshid</surname><given-names>Gelareh</given-names></name><xref ref-type="aff" rid="A11">10</xref></contrib><contrib contrib-type="author"><name><surname>Fox</surname><given-names>Stephen B</given-names></name><xref ref-type="aff" rid="A12">11</xref></contrib><contrib contrib-type="author"><name><surname>Ichihara</surname><given-names>Shu</given-names></name><xref ref-type="aff" rid="A13">12</xref></contrib><contrib contrib-type="author"><name><surname>Lakhani</surname><given-names>Sunil R</given-names></name><xref ref-type="aff" rid="A14">13</xref></contrib><contrib contrib-type="author"><name><surname>Rakha</surname><given-names>Emad A</given-names></name><xref ref-type="aff" rid="A9">8</xref></contrib><contrib contrib-type="author"><name><surname>Reis-Filho</surname><given-names>Jorge S</given-names></name><xref ref-type="aff" rid="A6">5</xref></contrib><contrib contrib-type="author"><name><surname>Richardson</surname><given-names>Andrea L</given-names></name><xref ref-type="aff" rid="A15">14</xref></contrib><contrib contrib-type="author"><name><surname>Sahin</surname><given-names>Aysegul</given-names></name><xref ref-type="aff" rid="A16">15</xref></contrib><contrib contrib-type="author"><name><surname>Schmitt</surname><given-names>Fernando C</given-names></name><xref ref-type="aff" rid="A17">16</xref></contrib><contrib contrib-type="author"><name><surname>Schnitt</surname><given-names>Stuart J</given-names></name><xref ref-type="aff" rid="A18">17</xref></contrib><contrib contrib-type="author"><name><surname>Siziopikou</surname><given-names>Kalliopi P</given-names></name><xref ref-type="aff" rid="A19">18</xref></contrib><contrib contrib-type="author"><name><surname>Soares</surname><given-names>Fernando A</given-names></name><xref ref-type="aff" rid="A20">19</xref></contrib><contrib contrib-type="author"><name><surname>Tse</surname><given-names>Gary M</given-names></name><xref ref-type="aff" rid="A21">20</xref></contrib><contrib contrib-type="author"><name><surname>Vincent-Salomon</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="A22">21</xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Puay Hoon</given-names></name></contrib></contrib-group><aff id="A1">Department of Pathology, Singapore General Hospital, Singapore</aff><aff id="A2"><label>1</label>Women’s Pathology Consultants, Ruffolo Hooper & Associates, Tampa, FL, USA</aff><aff id="A3"><label>2</label>Department of Pathology, UCLA Medical Center, Santa Monica, CA, USA</aff><aff id="A4"><label>3</label>Departments of Pathology and Internal Medicine, Clarian Pathology Laboratory of Indiana University, Indianapolis, IN, USA</aff><aff id="A5"><label>4</label>Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA</aff><aff id="A6"><label>5</label>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA</aff><aff id="A7"><label>6</label>Servicio de Anatomía Patológica, Hospital Universitario Ramón y Cajal, Madrid, Spain</aff><aff id="A8"><label>7</label>University of Pittsburgh Medical Center, Pittsburgh, PA, USA</aff><aff id="A9"><label>8</label>Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK</aff><aff id="A10"><label>9</label>Sezione Anatomia e Istologia Patologica, ‘M. Malpighi’ Università di Bologna, Bologna, Italy</aff><aff id="A11"><label>10</label>BreastScreen SA, Discipline of Medicine, Adelaide University and Directorate of Surgical Pathology, SA Pathology, Adelaide, South Australia</aff><aff id="A12"><label>11</label>Pathology Department, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Vic., Australia</aff><aff id="A13"><label>12</label>Department of Pathology, Nagoya Medical Center, Nagoya, Japan</aff><aff id="A14"><label>13</label>School of Medicine and Pathology Queensland, The Royal Brisbane & Women’s Hospital, University of Queensland Centre for Clinical Research, Brisbane, Qld, Australia</aff><aff id="A15"><label>14</label>Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</aff><aff id="A16"><label>15</label>Department of Pathology, Division of Pathology/Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA</aff><aff id="A17"><label>16</label>Laboratoire national de santé, Luxembourg city, Luxembourg</aff><aff id="A18"><label>17</label>Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA</aff><aff id="A19"><label>18</label>Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, USA</aff><aff id="A20"><label>19</label>Department of Anatomic Pathology, A. C. Camargo Cancer Centre, São Paulo, Brazil</aff><aff id="A21"><label>20</label>Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong</aff><aff id="A22"><label>21</label>Pôle Pathologie-Génétique-Immunologie, Institut Curie, Paris, France</aff><author-notes><corresp id="FN1">Address for correspondence: Dr Puay Hoon Tan, Department of Pathology, Singapore General Hospital, Diagnostics Tower, Level 7, Academia, 20 College Road 169856, Singapore. <email>tan.puay.hoon@sgh.com.sg</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>5</day><month>8</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>19</day><month>9</month><year>2016</year></pub-date><volume>68</volume><issue>1</issue><fpage>5</fpage><lpage>21</lpage><pmc-comment>elocation-id from pubmed: 10.1111/his.12876</pmc-comment>
<abstract><p id="P1">Phyllodes tumours constitute an uncommon but complex group of mammary fibroepithelial lesions. Accurate and reproducible grading of these tumours has long been challenging, owing to the need to assess multiple stratified histological parameters, which may be weighted differently by individual pathologists. Distinction of benign phyllodes tumours from cellular fibroadenomas is fraught with difficulty, due to overlapping microscopic features. Similarly, separation of the malignant phyllodes tumour from spindle cell metaplastic carcinoma and primary breast sarcoma can be problematic. Phyllodes tumours are treated by surgical excision. However, there is no consensus on the definition of an appropriate surgical margin to ensure completeness of excision and reduction of recurrence risk. Interpretive subjectivity, overlapping histological diagnostic criteria, suboptimal correlation between histological classification and clinical behaviour and the lack of robust molecular predictors of outcome make further investigation of the pathogenesis of these fascinating tumours a matter of active research. This review consolidates the current understanding of their pathobiology and clinical behaviour, and includes proposals for a rational approach to the classification and management of phyllodes tumours.</p></abstract><kwd-group><kwd>classification</kwd><kwd>fibroadenoma</kwd><kwd>malignant</kwd><kwd>metastasis</kwd><kwd>phyllodes</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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