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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Optomechanical Response of Human and Monkey Lenses in a Lens Stretcher</title><author><name sortKey="Manns, Fabrice" sort="Manns, Fabrice" uniqKey="Manns F" first="Fabrice" last="Manns">Fabrice Manns</name><affiliation><nlm:aff id="A1">Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida</nlm:aff></affiliation></author><author><name sortKey="Parel, Jean Marie" sort="Parel, Jean Marie" uniqKey="Parel J" first="Jean-Marie" last="Parel">Jean-Marie Parel</name><affiliation><nlm:aff id="A1">Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida</nlm:aff></affiliation></author><author><name sortKey="Denham, David" sort="Denham, David" uniqKey="Denham D" first="David" last="Denham">David Denham</name><affiliation><nlm:aff id="A1">Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida</nlm:aff></affiliation></author><author><name sortKey="Billotte, Christian" sort="Billotte, Christian" uniqKey="Billotte C" first="Christian" last="Billotte">Christian Billotte</name><affiliation><nlm:aff id="A3">Service d’Ophtalmologie, Centre Hospitalier Universitaire de Caen, France</nlm:aff></affiliation></author><author><name sortKey="Ziebarth, Noel" sort="Ziebarth, Noel" uniqKey="Ziebarth N" first="Noel" last="Ziebarth">Noel Ziebarth</name><affiliation><nlm:aff id="A1">Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida</nlm:aff></affiliation></author><author><name sortKey="Borja, David" sort="Borja, David" uniqKey="Borja D" first="David" last="Borja">David Borja</name><affiliation><nlm:aff id="A1">Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida</nlm:aff></affiliation></author><author><name sortKey="Fernandez, Viviana" sort="Fernandez, Viviana" uniqKey="Fernandez V" first="Viviana" last="Fernandez">Viviana Fernandez</name><affiliation><nlm:aff id="A1">Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</nlm:aff></affiliation></author><author><name sortKey="Aly, Mohammed" sort="Aly, Mohammed" uniqKey="Aly M" first="Mohammed" last="Aly">Mohammed Aly</name><affiliation><nlm:aff id="A1">Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</nlm:aff></affiliation></author><author><name sortKey="Arrieta, Esdras" sort="Arrieta, Esdras" uniqKey="Arrieta E" first="Esdras" last="Arrieta">Esdras Arrieta</name><affiliation><nlm:aff id="A1">Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</nlm:aff></affiliation></author><author><name sortKey="Ho, Arthur" sort="Ho, Arthur" uniqKey="Ho A" first="Arthur" last="Ho">Arthur Ho</name><affiliation><nlm:aff id="A4">Vision Cooperative Research Centre, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Institute for Eye Research, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">School of Optometry and Vision Sciences, University of New South Wales, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Holden, Brien" sort="Holden, Brien" uniqKey="Holden B" first="Brien" last="Holden">Brien Holden</name><affiliation><nlm:aff id="A4">Vision Cooperative Research Centre, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Institute for Eye Research, Sydney, Australia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17591897</idno><idno type="pmc">3429371</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429371</idno><idno type="RBID">PMC:3429371</idno><idno type="doi">10.1167/iovs.06-1376</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">001F71</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F71</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Optomechanical Response of Human and Monkey Lenses in a Lens Stretcher</title><author><name sortKey="Manns, Fabrice" sort="Manns, Fabrice" uniqKey="Manns F" first="Fabrice" last="Manns">Fabrice Manns</name><affiliation><nlm:aff id="A1">Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida</nlm:aff></affiliation></author><author><name sortKey="Parel, Jean Marie" sort="Parel, Jean Marie" uniqKey="Parel J" first="Jean-Marie" last="Parel">Jean-Marie Parel</name><affiliation><nlm:aff id="A1">Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida</nlm:aff></affiliation></author><author><name sortKey="Denham, David" sort="Denham, David" uniqKey="Denham D" first="David" last="Denham">David Denham</name><affiliation><nlm:aff id="A1">Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida</nlm:aff></affiliation></author><author><name sortKey="Billotte, Christian" sort="Billotte, Christian" uniqKey="Billotte C" first="Christian" last="Billotte">Christian Billotte</name><affiliation><nlm:aff id="A3">Service d’Ophtalmologie, Centre Hospitalier Universitaire de Caen, France</nlm:aff></affiliation></author><author><name sortKey="Ziebarth, Noel" sort="Ziebarth, Noel" uniqKey="Ziebarth N" first="Noel" last="Ziebarth">Noel Ziebarth</name><affiliation><nlm:aff id="A1">Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida</nlm:aff></affiliation></author><author><name sortKey="Borja, David" sort="Borja, David" uniqKey="Borja D" first="David" last="Borja">David Borja</name><affiliation><nlm:aff id="A1">Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida</nlm:aff></affiliation></author><author><name sortKey="Fernandez, Viviana" sort="Fernandez, Viviana" uniqKey="Fernandez V" first="Viviana" last="Fernandez">Viviana Fernandez</name><affiliation><nlm:aff id="A1">Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</nlm:aff></affiliation></author><author><name sortKey="Aly, Mohammed" sort="Aly, Mohammed" uniqKey="Aly M" first="Mohammed" last="Aly">Mohammed Aly</name><affiliation><nlm:aff id="A1">Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</nlm:aff></affiliation></author><author><name sortKey="Arrieta, Esdras" sort="Arrieta, Esdras" uniqKey="Arrieta E" first="Esdras" last="Arrieta">Esdras Arrieta</name><affiliation><nlm:aff id="A1">Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</nlm:aff></affiliation></author><author><name sortKey="Ho, Arthur" sort="Ho, Arthur" uniqKey="Ho A" first="Arthur" last="Ho">Arthur Ho</name><affiliation><nlm:aff id="A4">Vision Cooperative Research Centre, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Institute for Eye Research, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">School of Optometry and Vision Sciences, University of New South Wales, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Holden, Brien" sort="Holden, Brien" uniqKey="Holden B" first="Brien" last="Holden">Brien Holden</name><affiliation><nlm:aff id="A4">Vision Cooperative Research Centre, Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Institute for Eye Research, Sydney, Australia</nlm:aff></affiliation></author></analytic><series><title level="j">Investigative ophthalmology & visual science</title><idno type="ISSN">0146-0404</idno><idno type="eISSN">1552-5783</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">To quantify the forces necessary to change the shape and optical power of human and monkey lenses.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Cynomolgus monkey (<italic>n</italic> = 48; age: 3.8–11 years), rhesus monkey (<italic>n</italic> = 35; age: 0.7–17 years) and human (<italic>n</italic> = 20, age 8–70 years) eyes obtained postmortem, including the lens, capsule, zonules, ciliary body, and sclera were mounted in an optomechanical lens-stretching system. Starting at zero load, the lenses were symmetrically stretched in a stepwise fashion in 0.25- or 0.5-mm steps. The load, lens diameter, inner ciliary body diameter, and lens power were measured at each step and the diameter- and power-load responses were quantified.</p></sec><sec id="S3"><title>Results</title><p id="P3">The diameter- and power-load responses were found to be linear in the physiologically relevant range of stretching. The average change in cynomolgus, rhesus, and human lens diameter, respectively, was 0.094, 0.109, and 0.069 mm/g in young lenses, and 0.069, 0.067, and 0.036, mm/g in older lenses. For the same lenses, the average change in lens power was −3.73, −2.83, and −1.22 D/g in young lenses and −2.46, − 2.16, and −0.49 D/g in older lenses.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The force necessary to change the lens diameter and lens power increases with age in human and monkey lenses. The results agree with the Helmholtz theory of accommodation and with presbyopia theories that predict that the force required to disaccommodate the lens increases with age.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7703701</journal-id><journal-id journal-id-type="pubmed-jr-id">4371</journal-id><journal-id journal-id-type="nlm-ta">Invest Ophthalmol Vis Sci</journal-id><journal-id journal-id-type="iso-abbrev">Invest. Ophthalmol. Vis. Sci.</journal-id><journal-title-group><journal-title>Investigative ophthalmology & visual science</journal-title></journal-title-group><issn pub-type="ppub">0146-0404</issn><issn pub-type="epub">1552-5783</issn></journal-meta><article-meta><article-id pub-id-type="pmid">17591897</article-id><article-id pub-id-type="pmc">3429371</article-id><article-id pub-id-type="doi">10.1167/iovs.06-1376</article-id><article-id pub-id-type="manuscript">NIHMS396538</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Optomechanical Response of Human and Monkey Lenses in a Lens Stretcher</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Manns</surname><given-names>Fabrice</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Parel</surname><given-names>Jean-Marie</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Denham</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Billotte</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Ziebarth</surname><given-names>Noel</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Borja</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Fernandez</surname><given-names>Viviana</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Aly</surname><given-names>Mohammed</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Arrieta</surname><given-names>Esdras</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ho</surname><given-names>Arthur</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Holden</surname><given-names>Brien</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib></contrib-group><aff id="A1"><label>1</label>Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida</aff><aff id="A2"><label>2</label>Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida</aff><aff id="A3"><label>3</label>Service d’Ophtalmologie, Centre Hospitalier Universitaire de Caen, France</aff><aff id="A4"><label>4</label>Vision Cooperative Research Centre, Sydney, Australia</aff><aff id="A5"><label>5</label>Institute for Eye Research, Sydney, Australia</aff><aff id="A6"><label>6</label>School of Optometry and Vision Sciences, University of New South Wales, Sydney, Australia</aff><author-notes><corresp id="FN1">Corresponding author: Fabrice Manns, Bascom Palmer Eye Institute, 1638 NW 10 Avenue, Miami, FL 33136; <email>fmanns@miami.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>9</day><month>8</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2007</year></pub-date><pub-date pub-type="pmc-release"><day>28</day><month>8</month><year>2012</year></pub-date><volume>48</volume><issue>7</issue><fpage>3260</fpage><lpage>3268</lpage><permissions><copyright-statement>Copyright © Association for Research in Vision and Ophthalmology</copyright-statement></permissions><abstract><sec id="S1"><title>Purpose</title><p id="P1">To quantify the forces necessary to change the shape and optical power of human and monkey lenses.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Cynomolgus monkey (<italic>n</italic> = 48; age: 3.8–11 years), rhesus monkey (<italic>n</italic> = 35; age: 0.7–17 years) and human (<italic>n</italic> = 20, age 8–70 years) eyes obtained postmortem, including the lens, capsule, zonules, ciliary body, and sclera were mounted in an optomechanical lens-stretching system. Starting at zero load, the lenses were symmetrically stretched in a stepwise fashion in 0.25- or 0.5-mm steps. The load, lens diameter, inner ciliary body diameter, and lens power were measured at each step and the diameter- and power-load responses were quantified.</p></sec><sec id="S3"><title>Results</title><p id="P3">The diameter- and power-load responses were found to be linear in the physiologically relevant range of stretching. The average change in cynomolgus, rhesus, and human lens diameter, respectively, was 0.094, 0.109, and 0.069 mm/g in young lenses, and 0.069, 0.067, and 0.036, mm/g in older lenses. For the same lenses, the average change in lens power was −3.73, −2.83, and −1.22 D/g in young lenses and −2.46, − 2.16, and −0.49 D/g in older lenses.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The force necessary to change the lens diameter and lens power increases with age in human and monkey lenses. The results agree with the Helmholtz theory of accommodation and with presbyopia theories that predict that the force required to disaccommodate the lens increases with age.</p></sec></abstract><funding-group><award-group><funding-source country="United States">National Eye Institute : NEI</funding-source><award-id>R01 EY014225 || EY</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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