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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A genome-wide association study for colorectal cancer identifies a risk locus in 14q23.1</title><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><affiliation><nlm:aff id="A1">Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada</nlm:aff></affiliation></author><author><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Loo, Lenora W M" sort="Loo, Lenora W M" uniqKey="Loo L" first="Lenora W. M." last="Loo">Lenora W. M. Loo</name><affiliation><nlm:aff id="A3">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</nlm:aff></affiliation></author><author><name sortKey="Zaidi, Syed H E" sort="Zaidi, Syed H E" uniqKey="Zaidi S" first="Syed H. E." last="Zaidi">Syed H. E. Zaidi</name><affiliation><nlm:aff id="A1">Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada</nlm:aff></affiliation></author><author><name sortKey="Wang, Hansong" sort="Wang, Hansong" uniqKey="Wang H" first="Hansong" last="Wang">Hansong Wang</name><affiliation><nlm:aff id="A3">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</nlm:aff></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation><nlm:aff id="A4">Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name><affiliation><nlm:aff id="A5">Service de Génétique Médicale, CHU Nantes, Nantes, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">EA 4273, Faculté de médecine, Université de Nantes, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A7">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A8">German Cancer Consortium (DKTK), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Campbell, Peter T" sort="Campbell, Peter T" uniqKey="Campbell P" first="Peter T." last="Campbell">Peter T. Campbell</name><affiliation><nlm:aff id="A10">American Cancer Society, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><affiliation><nlm:aff id="A11">Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A13">Division of Cancer Epidemiology, Unit of Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Du, Mengmeng" sort="Du, Mengmeng" uniqKey="Du M" first="Mengmeng" last="Du">Mengmeng Du</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Edlund, Christopher K" sort="Edlund, Christopher K" uniqKey="Edlund C" first="Christopher K." last="Edlund">Christopher K. Edlund</name><affiliation><nlm:aff id="A14">USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation><nlm:aff id="A15">Samuel Lunenfeld Research Institute, Toronto, ON M5S 1X5, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Division of General Surgery, Toronto General Hospital, Toronto, ON M5G 2C4, Canada</nlm:aff></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W." last="Haile">Robert W. Haile</name><affiliation><nlm:aff id="A17">Department of Medicine, Division of Oncology, Stanford University, California, USA</nlm:aff></affiliation></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A." last="Harrison">Tabitha A. Harrison</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation><nlm:aff id="A7">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A18">Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Hou, Lifang" sort="Hou, Lifang" uniqKey="Hou L" first="Lifang" last="Hou">Lifang Hou</name><affiliation><nlm:aff id="A19"> Department of Preventive Medicine and the Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Illinois</nlm:aff></affiliation></author><author><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Department of Biostatistics, University of Washington, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J." last="Jacobs">Eric J. Jacobs</name><affiliation><nlm:aff id="A10">American Cancer Society, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A." last="Jenkins">Mark A. Jenkins</name><affiliation><nlm:aff id="A18">Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Jeon, Jihyoun" sort="Jeon, Jihyoun" uniqKey="Jeon J" first="Jihyoun" last="Jeon">Jihyoun Jeon</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name><affiliation><nlm:aff id="A5">Service de Génétique Médicale, CHU Nantes, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation><nlm:aff id="A21">Case Comprehensive Cancer Center and Swetland Center for Environmental Health, Case Western Reserve University, Cleveland, Ohio</nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><affiliation><nlm:aff id="A22">Department of Health Sciences Research, Mayo Clinic, Scottsdale, Arizona</nlm:aff></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D." last="Potter">John D. Potter</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Centre for Public Health Research, Massey University, Wellington, New Zealand</nlm:aff></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><nlm:aff id="A25">Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Clalit Health Services National Cancer Control Center, Haifa, Israel</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A13">Division of Cancer Epidemiology, Unit of Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><affiliation><nlm:aff id="A28">Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation><nlm:aff id="A14">USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation><nlm:aff id="A29">Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A18">Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><affiliation><nlm:aff id="A32">Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA</nlm:aff></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Woods, Michael O" sort="Woods, Michael O" uniqKey="Woods M" first="Michael O." last="Woods">Michael O. Woods</name><affiliation><nlm:aff id="A33">Discipline of Genetics, Memorial University of Newfoundland, St. John's, NF A1B 3V6, Canada</nlm:aff></affiliation></author><author><name sortKey="Cotterchio, Michelle" sort="Cotterchio, Michelle" uniqKey="Cotterchio M" first="Michelle" last="Cotterchio">Michelle Cotterchio</name><affiliation><nlm:aff id="A34">Cancer Care Ontario, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Marchand, Loic Le" sort="Marchand, Loic Le" uniqKey="Marchand L" first="Loic Le" last="Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="A3">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</nlm:aff></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation><nlm:aff id="A14">USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Gruber, Steven B" sort="Gruber, Steven B" uniqKey="Gruber S" first="Steven B." last="Gruber">Steven B. Gruber</name><affiliation><nlm:aff id="A14">USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A35">USC Norris Comprehensive Cancer Center, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation><affiliation><nlm:aff id="A36">School of Public Health, University of Washington, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><affiliation><nlm:aff id="A1">Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Department of Medical Biophysics, University of Toronto, Toronto, ON M5S 1A1, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26404086</idno><idno type="pmc">4687971</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687971</idno><idno type="RBID">PMC:4687971</idno><idno type="doi">10.1007/s00439-015-1598-6</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001F69</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F69</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A genome-wide association study for colorectal cancer identifies a risk locus in 14q23.1</title><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><affiliation><nlm:aff id="A1">Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada</nlm:aff></affiliation></author><author><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Loo, Lenora W M" sort="Loo, Lenora W M" uniqKey="Loo L" first="Lenora W. M." last="Loo">Lenora W. M. Loo</name><affiliation><nlm:aff id="A3">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</nlm:aff></affiliation></author><author><name sortKey="Zaidi, Syed H E" sort="Zaidi, Syed H E" uniqKey="Zaidi S" first="Syed H. E." last="Zaidi">Syed H. E. Zaidi</name><affiliation><nlm:aff id="A1">Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada</nlm:aff></affiliation></author><author><name sortKey="Wang, Hansong" sort="Wang, Hansong" uniqKey="Wang H" first="Hansong" last="Wang">Hansong Wang</name><affiliation><nlm:aff id="A3">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</nlm:aff></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation><nlm:aff id="A4">Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name><affiliation><nlm:aff id="A5">Service de Génétique Médicale, CHU Nantes, Nantes, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">EA 4273, Faculté de médecine, Université de Nantes, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A7">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A8">German Cancer Consortium (DKTK), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Campbell, Peter T" sort="Campbell, Peter T" uniqKey="Campbell P" first="Peter T." last="Campbell">Peter T. Campbell</name><affiliation><nlm:aff id="A10">American Cancer Society, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><affiliation><nlm:aff id="A11">Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A13">Division of Cancer Epidemiology, Unit of Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Du, Mengmeng" sort="Du, Mengmeng" uniqKey="Du M" first="Mengmeng" last="Du">Mengmeng Du</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Edlund, Christopher K" sort="Edlund, Christopher K" uniqKey="Edlund C" first="Christopher K." last="Edlund">Christopher K. Edlund</name><affiliation><nlm:aff id="A14">USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation><nlm:aff id="A15">Samuel Lunenfeld Research Institute, Toronto, ON M5S 1X5, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Division of General Surgery, Toronto General Hospital, Toronto, ON M5G 2C4, Canada</nlm:aff></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W." last="Haile">Robert W. Haile</name><affiliation><nlm:aff id="A17">Department of Medicine, Division of Oncology, Stanford University, California, USA</nlm:aff></affiliation></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A." last="Harrison">Tabitha A. Harrison</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation><nlm:aff id="A7">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A18">Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Hou, Lifang" sort="Hou, Lifang" uniqKey="Hou L" first="Lifang" last="Hou">Lifang Hou</name><affiliation><nlm:aff id="A19"> Department of Preventive Medicine and the Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Illinois</nlm:aff></affiliation></author><author><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Department of Biostatistics, University of Washington, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J." last="Jacobs">Eric J. Jacobs</name><affiliation><nlm:aff id="A10">American Cancer Society, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A." last="Jenkins">Mark A. Jenkins</name><affiliation><nlm:aff id="A18">Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Jeon, Jihyoun" sort="Jeon, Jihyoun" uniqKey="Jeon J" first="Jihyoun" last="Jeon">Jihyoun Jeon</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name><affiliation><nlm:aff id="A5">Service de Génétique Médicale, CHU Nantes, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation><nlm:aff id="A21">Case Comprehensive Cancer Center and Swetland Center for Environmental Health, Case Western Reserve University, Cleveland, Ohio</nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><affiliation><nlm:aff id="A22">Department of Health Sciences Research, Mayo Clinic, Scottsdale, Arizona</nlm:aff></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D." last="Potter">John D. Potter</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Centre for Public Health Research, Massey University, Wellington, New Zealand</nlm:aff></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><nlm:aff id="A25">Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Clalit Health Services National Cancer Control Center, Haifa, Israel</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A13">Division of Cancer Epidemiology, Unit of Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><affiliation><nlm:aff id="A28">Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation><nlm:aff id="A14">USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation><nlm:aff id="A29">Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A18">Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><affiliation><nlm:aff id="A32">Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA</nlm:aff></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Woods, Michael O" sort="Woods, Michael O" uniqKey="Woods M" first="Michael O." last="Woods">Michael O. Woods</name><affiliation><nlm:aff id="A33">Discipline of Genetics, Memorial University of Newfoundland, St. John's, NF A1B 3V6, Canada</nlm:aff></affiliation></author><author><name sortKey="Cotterchio, Michelle" sort="Cotterchio, Michelle" uniqKey="Cotterchio M" first="Michelle" last="Cotterchio">Michelle Cotterchio</name><affiliation><nlm:aff id="A34">Cancer Care Ontario, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Marchand, Loic Le" sort="Marchand, Loic Le" uniqKey="Marchand L" first="Loic Le" last="Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="A3">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</nlm:aff></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation><nlm:aff id="A14">USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Gruber, Steven B" sort="Gruber, Steven B" uniqKey="Gruber S" first="Steven B." last="Gruber">Steven B. Gruber</name><affiliation><nlm:aff id="A14">USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A35">USC Norris Comprehensive Cancer Center, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation><nlm:aff id="A2">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation><affiliation><nlm:aff id="A36">School of Public Health, University of Washington, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><affiliation><nlm:aff id="A1">Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Department of Medical Biophysics, University of Toronto, Toronto, ON M5S 1A1, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada</nlm:aff></affiliation></author></analytic><series><title level="j">Human genetics</title><idno type="ISSN">0340-6717</idno><idno type="eISSN">1432-1203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P44">Over 50 loci associated with colorectal cancer (CRC) have been uncovered by genome-wide association studies (GWAS). Identifying additional loci has the potential to help elucidate aspects of the underlying biological processes leading to better understanding of the pathogenesis of the disease. We re-evaluated a GWAS by excluding controls that have family history of CRC or personal history of CR polyps, as we hypothesized that their inclusion reduces power to detect associations. This is supported empirically and through simulations. Two-phase GWAS analysis was performed in a total of 16,517 cases and 14,487 controls. We identified rs17094983, a SNP associated with risk of CRC (<italic>p</italic>=2.5×10<sup>−10</sup>; odds ratio estimated by re-including all controls (OR)=0.87, 95% confidence interval (CI): 0.83–0.91; minor allele frequency (MAF)=13%). Results were replicated in samples of African descent (1,894 cases and 4,703 controls; <italic>p</italic>=0.01; OR=0.86, 95% CI: 0.77–0.97; MAF=16%). Gene expression data in 195 colon adenocarcinomas and 59 normal colon tissues from two different studies revealed that this locus has genotypes that are associated with RTN1 (Reticulon 1) expression (<italic>p</italic>=0.001), a protein-coding gene involved in survival and proliferation of cancer cells that is highly expressed in normal colon tissues but has significantly reduced expression in tumor cells (<italic>p</italic>=1.3×10<sup>−8</sup>).</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7613873</journal-id><journal-id journal-id-type="pubmed-jr-id">4137</journal-id><journal-id journal-id-type="nlm-ta">Hum Genet</journal-id><journal-id journal-id-type="iso-abbrev">Hum. Genet.</journal-id><journal-title-group><journal-title>Human genetics</journal-title></journal-title-group><issn pub-type="ppub">0340-6717</issn><issn pub-type="epub">1432-1203</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26404086</article-id><article-id pub-id-type="pmc">4687971</article-id><article-id pub-id-type="doi">10.1007/s00439-015-1598-6</article-id><article-id pub-id-type="manuscript">NIHMS744271</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A genome-wide association study for colorectal cancer identifies a risk locus in 14q23.1</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Lemire</surname><given-names>Mathieu</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Qu</surname><given-names>Conghui</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Loo</surname><given-names>Lenora W.M.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Zaidi</surname><given-names>Syed H.E.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Hansong</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Berndt</surname><given-names>Sonja I.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Bézieau</surname><given-names>Stéphane</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Brenner</surname><given-names>Hermann</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Campbell</surname><given-names>Peter T.</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Andrew T.</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Du</surname><given-names>Mengmeng</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Edlund</surname><given-names>Christopher K.</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Gallinger</surname><given-names>Steven</given-names></name><xref ref-type="aff" rid="A15">15</xref><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Haile</surname><given-names>Robert W.</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Harrison</surname><given-names>Tabitha A.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hoffmeister</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L.</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Hou</surname><given-names>Lifang</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Hsu</surname><given-names>Li</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Jacobs</surname><given-names>Eric J.</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Jenkins</surname><given-names>Mark A.</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Jeon</surname><given-names>Jihyoun</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Küry</surname><given-names>Sébastien</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Li</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Lindor</surname><given-names>Noralane M.</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Newcomb</surname><given-names>Polly A.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Potter</surname><given-names>John D.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A23">23</xref><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Rennert</surname><given-names>Gad</given-names></name><xref ref-type="aff" rid="A25">25</xref><xref ref-type="aff" rid="A26">26</xref><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Rudolph</surname><given-names>Anja</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Schoen</surname><given-names>Robert E.</given-names></name><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Schumacher</surname><given-names>Fredrick R.</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Seminara</surname><given-names>Daniela</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Severi</surname><given-names>Gianluca</given-names></name><xref ref-type="aff" rid="A18">18</xref><xref ref-type="aff" rid="A30">30</xref><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Slattery</surname><given-names>Martha L.</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>White</surname><given-names>Emily</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Woods</surname><given-names>Michael O.</given-names></name><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Cotterchio</surname><given-names>Michelle</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Marchand</surname><given-names>Loic Le</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Casey</surname><given-names>Graham</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Gruber</surname><given-names>Steven B.</given-names></name><xref ref-type="aff" rid="A14">14</xref><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Peters</surname><given-names>Ulrike</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Hudson</surname><given-names>Thomas J.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A37">37</xref><xref ref-type="aff" rid="A38">38</xref></contrib></contrib-group><aff id="A1"><label>1</label>Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada</aff><aff id="A2"><label>2</label>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington</aff><aff id="A3"><label>3</label>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii</aff><aff id="A4"><label>4</label>Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA</aff><aff id="A5"><label>5</label>Service de Génétique Médicale, CHU Nantes, Nantes, France</aff><aff id="A6"><label>6</label>EA 4273, Faculté de médecine, Université de Nantes, Nantes, France</aff><aff id="A7"><label>7</label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A8"><label>8</label>German Cancer Consortium (DKTK), Heidelberg, Germany</aff><aff id="A9"><label>9</label>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A10"><label>10</label>American Cancer Society, Atlanta, GA, USA</aff><aff id="A11"><label>11</label>Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA</aff><aff id="A12"><label>12</label>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA</aff><aff id="A13"><label>13</label>Division of Cancer Epidemiology, Unit of Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A14"><label>14</label>USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</aff><aff id="A15"><label>15</label>Samuel Lunenfeld Research Institute, Toronto, ON M5S 1X5, Canada</aff><aff id="A16"><label>16</label>Division of General Surgery, Toronto General Hospital, Toronto, ON M5G 2C4, Canada</aff><aff id="A17"><label>17</label>Department of Medicine, Division of Oncology, Stanford University, California, USA</aff><aff id="A18"><label>18</label>Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia</aff><aff id="A19"><label>19</label> Department of Preventive Medicine and the Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Illinois</aff><aff id="A20"><label>20</label>Department of Biostatistics, University of Washington, Seattle, Washington</aff><aff id="A21"><label>21</label>Case Comprehensive Cancer Center and Swetland Center for Environmental Health, Case Western Reserve University, Cleveland, Ohio</aff><aff id="A22"><label>22</label>Department of Health Sciences Research, Mayo Clinic, Scottsdale, Arizona</aff><aff id="A23"><label>23</label>Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington</aff><aff id="A24"><label>24</label>Centre for Public Health Research, Massey University, Wellington, New Zealand</aff><aff id="A25"><label>25</label>Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel</aff><aff id="A26"><label>26</label>Clalit Health Services National Cancer Control Center, Haifa, Israel</aff><aff id="A27"><label>27</label>Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel</aff><aff id="A28"><label>28</label>Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA</aff><aff id="A29"><label>29</label>Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA</aff><aff id="A30"><label>30</label>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</aff><aff id="A31"><label>31</label>Human Genetics Foundation (HuGeF), Torino, Italy</aff><aff id="A32"><label>32</label>Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA</aff><aff id="A33"><label>33</label>Discipline of Genetics, Memorial University of Newfoundland, St. John's, NF A1B 3V6, Canada</aff><aff id="A34"><label>34</label>Cancer Care Ontario, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A35"><label>35</label>USC Norris Comprehensive Cancer Center, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</aff><aff id="A36"><label>36</label>School of Public Health, University of Washington, Seattle, Washington</aff><aff id="A37"><label>37</label>Department of Medical Biophysics, University of Toronto, Toronto, ON M5S 1A1, Canada</aff><aff id="A38"><label>38</label>Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada</aff><author-notes><fn id="FN1"><p id="P1"><bold>E-mail addresses of authors:</bold> Mathieu Lemire <email>mathieu.lemire@oicr.on.ca</email></p><p id="P2">Conghui Qu <email>cqu@fredhutch.org</email></p><p id="P3">Lenora W.M. Loo <email>lloo@cc.hawaii.edu</email></p><p id="P4">Syed H. E. Zaidi <email>hassan.zaidi@oicr.on.ca</email></p><p id="P5">Hansong Wang <email>hwang@cc.hawaii.edu</email></p><p id="P6">Sonja I. Berndt <email>berndts@mail.nih.gov</email></p><p id="P7">Stéphane Bézieau <email>stephane.bezieau@univ-nantes.fr</email></p><p id="P8">Hermann Brenner <email>h.brenner@dkfz.de</email></p><p id="P9">Peter T. Campbell <email>Peter.Campbell@cancer.org</email></p><p id="P10">Andrew T. Chan <email>achan@mgh.harvard.edu</email></p><p id="P11">Jenny Chang-Claude <email>j.chang-claude@dkfz.de</email></p><p id="P12">Mengmeng Du <email>mdu@fredhutch.org</email></p><p id="P13">Christopher K. Edlund <email>cedlund@usc.edu</email></p><p id="P14">Steven Gallinger <email>Steven.Gallinger@uhn.on.ca</email></p><p id="P15">Robert W. Haile <email>rhaile@stanford.edu</email></p><p id="P16">Tabitha A. Harrison <email>tharriso@fredhutch.org</email></p><p id="P17">Michael Hoffmeister <email>m.hoffmeister@dkfz.de</email></p><p id="P18">John L. Hopper <email>j.hopper@unimelb.edu.au</email></p><p id="P19">Lifang Hou <email>l-hou@northwestern.edu</email></p><p id="P20">Li Hsu <email>lih@fredhutch.org</email></p><p id="P21">Eric J. Jacobs <email>Eric.Jacobs@cancer.org</email></p><p id="P22">Mark A. Jenkins <email>m.jenkins@unimelb.edu.au</email></p><p id="P23">Jihyoun Jeon <email>jhjeon@fredhutch.org</email></p><p id="P24">Sébastien Küry <email>sebastien.kury@chu-nantes.fr</email></p><p id="P25">Li Li <email>lxl62@cwru.edu</email></p><p id="P26">Noralane M. Lindor <email>nlindor@mayo.edu</email></p><p id="P27">Polly A. Newcomb <email>pnewcomb@fredhutch.org</email></p><p id="P28">John D. Potter <email>jpotter@fredhutch.org</email></p><p id="P29">Gad Rennert <email>rennert@tx.technion.ac.il</email></p><p id="P30">Anja Rudolph <email>a.rudolph@dkfz.de</email></p><p id="P31">Robert E. Schoen <email>rschoen@pitt.edu</email></p><p id="P32">Fredrick R. Schumacher <email>fschumac@usc.edu</email></p><p id="P33">Daniela Seminara <email>seminard@mail.nih.gov</email></p><p id="P34">Gianluca Severi <email>Gianluca.Severi@cancervic.org.au</email></p><p id="P35">Martha L. Slattery <email>marty.slattery@hsc.utah.edu</email></p><p id="P36">Emily White <email>ewhite@fredhutch.org</email></p><p id="P37">Michael O. Woods <email>mwoods@mun.ca</email></p><p id="P38">Michelle Cotterchio <email>michelle.cotterchio@cancercare.on.ca</email></p><p id="P39">Loic Le Marchand <email>loic@cc.hawaii.edu</email></p><p id="P40">Graham Casey <email>gcasey@usc.edu</email></p><p id="P41">Steven B. Gruber <email>sgruber@usc.edu</email></p><p id="P42">Ulrike Peters <email>upeters@fredhutch.org</email></p><p id="P43">Thomas J. Hudson <email>tom.hudson@oicr.on.ca</email></p></fn><corresp id="CR1"><bold>Correspondence</bold>: Mathieu Lemire, Ontario Insitute for Cancer Research, MaRS Centre, 661 University Avenue, Suite 510, Toronto, Ontario, Canada M5G 0A3, <email>mathieu.lemire@oicr.on.ca</email>, Tel: 416-673-8539, Fax: 416-673-6664</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>13</day><month>12</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>24</day><month>9</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>11</month><year>2016</year></pub-date><volume>134</volume><issue>0</issue><fpage>1249</fpage><lpage>1262</lpage><pmc-comment>elocation-id from pubmed: 10.1007/s00439-015-1598-6</pmc-comment>
<abstract><p id="P44">Over 50 loci associated with colorectal cancer (CRC) have been uncovered by genome-wide association studies (GWAS). Identifying additional loci has the potential to help elucidate aspects of the underlying biological processes leading to better understanding of the pathogenesis of the disease. We re-evaluated a GWAS by excluding controls that have family history of CRC or personal history of CR polyps, as we hypothesized that their inclusion reduces power to detect associations. This is supported empirically and through simulations. Two-phase GWAS analysis was performed in a total of 16,517 cases and 14,487 controls. We identified rs17094983, a SNP associated with risk of CRC (<italic>p</italic>=2.5×10<sup>−10</sup>; odds ratio estimated by re-including all controls (OR)=0.87, 95% confidence interval (CI): 0.83–0.91; minor allele frequency (MAF)=13%). Results were replicated in samples of African descent (1,894 cases and 4,703 controls; <italic>p</italic>=0.01; OR=0.86, 95% CI: 0.77–0.97; MAF=16%). Gene expression data in 195 colon adenocarcinomas and 59 normal colon tissues from two different studies revealed that this locus has genotypes that are associated with RTN1 (Reticulon 1) expression (<italic>p</italic>=0.001), a protein-coding gene involved in survival and proliferation of cancer cells that is highly expressed in normal colon tissues but has significantly reduced expression in tumor cells (<italic>p</italic>=1.3×10<sup>−8</sup>).</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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