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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide Association Study of Glioma and Meta-Analysis</title>
<author><name sortKey="Rajaraman, Preetha" sort="Rajaraman, Preetha" uniqKey="Rajaraman P" first="Preetha" last="Rajaraman">Preetha Rajaraman</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Melin, Beatrice S" sort="Melin, Beatrice S" uniqKey="Melin B" first="Beatrice S." last="Melin">Beatrice S. Melin</name>
<affiliation><nlm:aff id="A2">Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Core Genotyping Facility, National Cancer Institute, SAIC-Frederick, Inc., Gaithersburg, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mckean Cowdin, Roberta" sort="Mckean Cowdin, Roberta" uniqKey="Mckean Cowdin R" first="Roberta" last="Mckean-Cowdin">Roberta Mckean-Cowdin</name>
<affiliation><nlm:aff id="A4">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Michaud, Dominique" sort="Michaud, Dominique" uniqKey="Michaud D" first="Dominique" last="Michaud">Dominique Michaud</name>
<affiliation><nlm:aff id="A5">Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, RI, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A6">School of Public Health, Imperial College London, London, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Sophia S" sort="Wang, Sophia S" uniqKey="Wang S" first="Sophia S." last="Wang">Sophia S. Wang</name>
<affiliation><nlm:aff id="A7">Division of Cancer Etiology, Department of Population Sciences, City of Hope and the Beckman Research Institute, Duarte, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bondy, Melissa" sort="Bondy, Melissa" uniqKey="Bondy M" first="Melissa" last="Bondy">Melissa Bondy</name>
<affiliation><nlm:aff id="A8">Baylor College of Medicine, TX, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Houlston, Richard" sort="Houlston, Richard" uniqKey="Houlston R" first="Richard" last="Houlston">Richard Houlston</name>
<affiliation><nlm:aff id="A9">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jenkins, Robert B" sort="Jenkins, Robert B" uniqKey="Jenkins R" first="Robert B." last="Jenkins">Robert B. Jenkins</name>
<affiliation><nlm:aff id="A10">Mayo Clinic, MN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wrensch, Margaret" sort="Wrensch, Margaret" uniqKey="Wrensch M" first="Margaret" last="Wrensch">Margaret Wrensch</name>
<affiliation><nlm:aff id="A11">University of California San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yeager, Meredith" sort="Yeager, Meredith" uniqKey="Yeager M" first="Meredith" last="Yeager">Meredith Yeager</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Core Genotyping Facility, National Cancer Institute, SAIC-Frederick, Inc., Gaithersburg, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ahlbom, Anders" sort="Ahlbom, Anders" uniqKey="Ahlbom A" first="Anders" last="Ahlbom">Anders Ahlbom</name>
<affiliation><nlm:aff id="A12">Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andersson, Ulrika" sort="Andersson, Ulrika" uniqKey="Andersson U" first="Ulrika" last="Andersson">Ulrika Andersson</name>
<affiliation><nlm:aff id="A2">Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Freeman, Laura E Beane" sort="Freeman, Laura E Beane" uniqKey="Freeman L" first="Laura E. Beane" last="Freeman">Laura E. Beane Freeman</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Buring, Julie E" sort="Buring, Julie E" uniqKey="Buring J" first="Julie E." last="Buring">Julie E. Buring</name>
<affiliation><nlm:aff id="A13">Division of Preventive Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Butler, Mary Ann" sort="Butler, Mary Ann" uniqKey="Butler M" first="Mary Ann" last="Butler">Mary Ann Butler</name>
<affiliation><nlm:aff id="A14">National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Braganza, Melissa" sort="Braganza, Melissa" uniqKey="Braganza M" first="Melissa" last="Braganza">Melissa Braganza</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Carreon, Tania" sort="Carreon, Tania" uniqKey="Carreon T" first="Tania" last="Carreon">Tania Carreon</name>
<affiliation><nlm:aff id="A14">National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Feychting, Maria" sort="Feychting, Maria" uniqKey="Feychting M" first="Maria" last="Feychting">Maria Feychting</name>
<affiliation><nlm:aff id="A12">Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fleming, Sarah J" sort="Fleming, Sarah J" uniqKey="Fleming S" first="Sarah J." last="Fleming">Sarah J. Fleming</name>
<affiliation><nlm:aff id="A15">Division of Biostatistics, University of Leeds, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name>
<affiliation><nlm:aff id="A16">Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J. Michael" last="Gaziano">J. Michael Gaziano</name>
<affiliation><nlm:aff id="A13">Division of Preventive Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A17">Massachusetts Veteran’s Epidemiology, Research and Information Center, Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation><nlm:aff id="A18">Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A19">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hallmans, Goran" sort="Hallmans, Goran" uniqKey="Hallmans G" first="Goran" last="Hallmans">Goran Hallmans</name>
<affiliation><nlm:aff id="A20">Department of Public Health and Clinical Medicine/Nutritional Research, Umeå University, Umeå, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Henriksson, Roger" sort="Henriksson, Roger" uniqKey="Henriksson R" first="Roger" last="Henriksson">Roger Henriksson</name>
<affiliation><nlm:aff id="A2">Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hoffman Bolton, Judith" sort="Hoffman Bolton, Judith" uniqKey="Hoffman Bolton J" first="Judith" last="Hoffman-Bolton">Judith Hoffman-Bolton</name>
<affiliation><nlm:aff id="A21">Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Inskip, Peter D" sort="Inskip, Peter D" uniqKey="Inskip P" first="Peter D." last="Inskip">Peter D. Inskip</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Johansen, Christoffer" sort="Johansen, Christoffer" uniqKey="Johansen C" first="Christoffer" last="Johansen">Christoffer Johansen</name>
<affiliation><nlm:aff id="A22">The Danish Cancer Society Research Center, Unit of Survivorship, Copenhagen, Denmark</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kitahara, Cari M" sort="Kitahara, Cari M" uniqKey="Kitahara C" first="Cari M." last="Kitahara">Cari M. Kitahara</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<affiliation><nlm:aff id="A23">Centre National de Genotypage, IG/CEA, Evry Cedex, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A24">Foundation Jean Dauset-CEPH, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liu, Chenwei" sort="Liu, Chenwei" uniqKey="Liu C" first="Chenwei" last="Liu">Chenwei Liu</name>
<affiliation><nlm:aff id="A3">Core Genotyping Facility, National Cancer Institute, SAIC-Frederick, Inc., Gaithersburg, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
<affiliation><nlm:aff id="A25">University of Hawaii, Cancer Research Center</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Linet, Martha S" sort="Linet, Martha S" uniqKey="Linet M" first="Martha S." last="Linet">Martha S. Linet</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lonn, Stefan" sort="Lonn, Stefan" uniqKey="Lonn S" first="Stefan" last="Lonn">Stefan Lonn</name>
<affiliation><nlm:aff id="A12">Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A26">Medical Department, AstraZeneca Nordic, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name>
<affiliation><nlm:aff id="A27">Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A28">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Purdue, Mark P" sort="Purdue, Mark P" uniqKey="Purdue M" first="Mark P." last="Purdue">Mark P. Purdue</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ruder, Avima M" sort="Ruder, Avima M" uniqKey="Ruder A" first="Avima M." last="Ruder">Avima M. Ruder</name>
<affiliation><nlm:aff id="A14">National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sanson, Marc" sort="Sanson, Marc" uniqKey="Sanson M" first="Marc" last="Sanson">Marc Sanson</name>
<affiliation><nlm:aff id="A29">Service de Neurologie Mazarin, GH Pitié-Salpêtrière, APHP, and UMR 975 INSERM-UPMC, CRICM, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sesso, Howard D" sort="Sesso, Howard D" uniqKey="Sesso H" first="Howard D." last="Sesso">Howard D. Sesso</name>
<affiliation><nlm:aff id="A13">Division of Preventive Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation><nlm:aff id="A17">Massachusetts Veteran’s Epidemiology, Research and Information Center, Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Boston, MA, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A18">Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name>
<affiliation><nlm:aff id="A30">Vanderbilt University Medical Center, Nashville, TN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Simon, Matthias" sort="Simon, Matthias" uniqKey="Simon M" first="Matthias" last="Simon">Matthias Simon</name>
<affiliation><nlm:aff id="A31">Neurochirurgische Universitatsklinik, Bonn, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name>
<affiliation><nlm:aff id="A32">Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A33">Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L." last="Stevens">Victoria L. Stevens</name>
<affiliation><nlm:aff id="A16">Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Visvanathan, Kala" sort="Visvanathan, Kala" uniqKey="Visvanathan K" first="Kala" last="Visvanathan">Kala Visvanathan</name>
<affiliation><nlm:aff id="A21">Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A34">Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name>
<affiliation><nlm:aff id="A27">Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A28">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wolk, Alicja" sort="Wolk, Alicja" uniqKey="Wolk A" first="Alicja" last="Wolk">Alicja Wolk</name>
<affiliation><nlm:aff id="A35">Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zeleniuch Jacquotte, Anne" sort="Zeleniuch Jacquotte, Anne" uniqKey="Zeleniuch Jacquotte A" first="Anne" last="Zeleniuch-Jacquotte">Anne Zeleniuch-Jacquotte</name>
<affiliation><nlm:aff id="A36">Division of Epidemiology, Department of Environmental Medicine, NYU School of Medicine, New York, NY, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name>
<affiliation><nlm:aff id="A30">Vanderbilt University Medical Center, Nashville, TN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Decker, Paul" sort="Decker, Paul" uniqKey="Decker P" first="Paul" last="Decker">Paul Decker</name>
<affiliation><nlm:aff id="A10">Mayo Clinic, MN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Enciso Mora, Victor" sort="Enciso Mora, Victor" uniqKey="Enciso Mora V" first="Victor" last="Enciso-Mora">Victor Enciso-Mora</name>
<affiliation><nlm:aff id="A9">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fridley, Brooke" sort="Fridley, Brooke" uniqKey="Fridley B" first="Brooke" last="Fridley">Brooke Fridley</name>
<affiliation><nlm:aff id="A10">Mayo Clinic, MN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name>
<affiliation><nlm:aff id="A37">Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kosel, Matt" sort="Kosel, Matt" uniqKey="Kosel M" first="Matt" last="Kosel">Matt Kosel</name>
<affiliation><nlm:aff id="A10">Mayo Clinic, MN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lachance, Dan" sort="Lachance, Dan" uniqKey="Lachance D" first="Dan" last="Lachance">Dan Lachance</name>
<affiliation><nlm:aff id="A10">Mayo Clinic, MN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lau, Ching" sort="Lau, Ching" uniqKey="Lau C" first="Ching" last="Lau">Ching Lau</name>
<affiliation><nlm:aff id="A8">Baylor College of Medicine, TX, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rice, Terri" sort="Rice, Terri" uniqKey="Rice T" first="Terri" last="Rice">Terri Rice</name>
<affiliation><nlm:aff id="A11">University of California San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name>
<affiliation><nlm:aff id="A9">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A38">Division of Breast Cancer Research, Institute of Cancer Research , London, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wiemels, Joe" sort="Wiemels, Joe" uniqKey="Wiemels J" first="Joe" last="Wiemels">Joe Wiemels</name>
<affiliation><nlm:aff id="A11">University of California San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wiencke, John" sort="Wiencke, John" uniqKey="Wiencke J" first="John" last="Wiencke">John Wiencke</name>
<affiliation><nlm:aff id="A11">University of California San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shete, Sanjay" sort="Shete, Sanjay" uniqKey="Shete S" first="Sanjay" last="Shete">Sanjay Shete</name>
<affiliation><nlm:aff id="A39">Department of Biostatistics, MD Anderson Cancer Center, TX, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Xiang, Yong Bing" sort="Xiang, Yong Bing" uniqKey="Xiang Y" first="Yong-Bing" last="Xiang">Yong-Bing Xiang</name>
<affiliation><nlm:aff id="A37">Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Xiao, Yuanyuan" sort="Xiao, Yuanyuan" uniqKey="Xiao Y" first="Yuanyuan" last="Xiao">Yuanyuan Xiao</name>
<affiliation><nlm:aff id="A11">University of California San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hoover, Robert" sort="Hoover, Robert" uniqKey="Hoover R" first="Robert" last="Hoover">Robert Hoover</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fraumeni, Joseph F" sort="Fraumeni, Joseph F" uniqKey="Fraumeni J" first="Joseph F." last="Fraumeni">Joseph F. Fraumeni</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Core Genotyping Facility, National Cancer Institute, SAIC-Frederick, Inc., Gaithersburg, MD, USA</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22886559</idno>
<idno type="pmc">3761216</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761216</idno>
<idno type="RBID">PMC:3761216</idno>
<idno type="doi">10.1007/s00439-012-1212-0</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">001F66</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F66</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide Association Study of Glioma and Meta-Analysis</title>
<author><name sortKey="Rajaraman, Preetha" sort="Rajaraman, Preetha" uniqKey="Rajaraman P" first="Preetha" last="Rajaraman">Preetha Rajaraman</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Melin, Beatrice S" sort="Melin, Beatrice S" uniqKey="Melin B" first="Beatrice S." last="Melin">Beatrice S. Melin</name>
<affiliation><nlm:aff id="A2">Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Core Genotyping Facility, National Cancer Institute, SAIC-Frederick, Inc., Gaithersburg, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mckean Cowdin, Roberta" sort="Mckean Cowdin, Roberta" uniqKey="Mckean Cowdin R" first="Roberta" last="Mckean-Cowdin">Roberta Mckean-Cowdin</name>
<affiliation><nlm:aff id="A4">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Michaud, Dominique" sort="Michaud, Dominique" uniqKey="Michaud D" first="Dominique" last="Michaud">Dominique Michaud</name>
<affiliation><nlm:aff id="A5">Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, RI, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A6">School of Public Health, Imperial College London, London, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Sophia S" sort="Wang, Sophia S" uniqKey="Wang S" first="Sophia S." last="Wang">Sophia S. Wang</name>
<affiliation><nlm:aff id="A7">Division of Cancer Etiology, Department of Population Sciences, City of Hope and the Beckman Research Institute, Duarte, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bondy, Melissa" sort="Bondy, Melissa" uniqKey="Bondy M" first="Melissa" last="Bondy">Melissa Bondy</name>
<affiliation><nlm:aff id="A8">Baylor College of Medicine, TX, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Houlston, Richard" sort="Houlston, Richard" uniqKey="Houlston R" first="Richard" last="Houlston">Richard Houlston</name>
<affiliation><nlm:aff id="A9">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jenkins, Robert B" sort="Jenkins, Robert B" uniqKey="Jenkins R" first="Robert B." last="Jenkins">Robert B. Jenkins</name>
<affiliation><nlm:aff id="A10">Mayo Clinic, MN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wrensch, Margaret" sort="Wrensch, Margaret" uniqKey="Wrensch M" first="Margaret" last="Wrensch">Margaret Wrensch</name>
<affiliation><nlm:aff id="A11">University of California San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yeager, Meredith" sort="Yeager, Meredith" uniqKey="Yeager M" first="Meredith" last="Yeager">Meredith Yeager</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Core Genotyping Facility, National Cancer Institute, SAIC-Frederick, Inc., Gaithersburg, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ahlbom, Anders" sort="Ahlbom, Anders" uniqKey="Ahlbom A" first="Anders" last="Ahlbom">Anders Ahlbom</name>
<affiliation><nlm:aff id="A12">Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andersson, Ulrika" sort="Andersson, Ulrika" uniqKey="Andersson U" first="Ulrika" last="Andersson">Ulrika Andersson</name>
<affiliation><nlm:aff id="A2">Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Freeman, Laura E Beane" sort="Freeman, Laura E Beane" uniqKey="Freeman L" first="Laura E. Beane" last="Freeman">Laura E. Beane Freeman</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Buring, Julie E" sort="Buring, Julie E" uniqKey="Buring J" first="Julie E." last="Buring">Julie E. Buring</name>
<affiliation><nlm:aff id="A13">Division of Preventive Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Butler, Mary Ann" sort="Butler, Mary Ann" uniqKey="Butler M" first="Mary Ann" last="Butler">Mary Ann Butler</name>
<affiliation><nlm:aff id="A14">National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Braganza, Melissa" sort="Braganza, Melissa" uniqKey="Braganza M" first="Melissa" last="Braganza">Melissa Braganza</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Carreon, Tania" sort="Carreon, Tania" uniqKey="Carreon T" first="Tania" last="Carreon">Tania Carreon</name>
<affiliation><nlm:aff id="A14">National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Feychting, Maria" sort="Feychting, Maria" uniqKey="Feychting M" first="Maria" last="Feychting">Maria Feychting</name>
<affiliation><nlm:aff id="A12">Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fleming, Sarah J" sort="Fleming, Sarah J" uniqKey="Fleming S" first="Sarah J." last="Fleming">Sarah J. Fleming</name>
<affiliation><nlm:aff id="A15">Division of Biostatistics, University of Leeds, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name>
<affiliation><nlm:aff id="A16">Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J. Michael" last="Gaziano">J. Michael Gaziano</name>
<affiliation><nlm:aff id="A13">Division of Preventive Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A17">Massachusetts Veteran’s Epidemiology, Research and Information Center, Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation><nlm:aff id="A18">Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A19">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hallmans, Goran" sort="Hallmans, Goran" uniqKey="Hallmans G" first="Goran" last="Hallmans">Goran Hallmans</name>
<affiliation><nlm:aff id="A20">Department of Public Health and Clinical Medicine/Nutritional Research, Umeå University, Umeå, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Henriksson, Roger" sort="Henriksson, Roger" uniqKey="Henriksson R" first="Roger" last="Henriksson">Roger Henriksson</name>
<affiliation><nlm:aff id="A2">Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hoffman Bolton, Judith" sort="Hoffman Bolton, Judith" uniqKey="Hoffman Bolton J" first="Judith" last="Hoffman-Bolton">Judith Hoffman-Bolton</name>
<affiliation><nlm:aff id="A21">Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Inskip, Peter D" sort="Inskip, Peter D" uniqKey="Inskip P" first="Peter D." last="Inskip">Peter D. Inskip</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Johansen, Christoffer" sort="Johansen, Christoffer" uniqKey="Johansen C" first="Christoffer" last="Johansen">Christoffer Johansen</name>
<affiliation><nlm:aff id="A22">The Danish Cancer Society Research Center, Unit of Survivorship, Copenhagen, Denmark</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kitahara, Cari M" sort="Kitahara, Cari M" uniqKey="Kitahara C" first="Cari M." last="Kitahara">Cari M. Kitahara</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<affiliation><nlm:aff id="A23">Centre National de Genotypage, IG/CEA, Evry Cedex, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A24">Foundation Jean Dauset-CEPH, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liu, Chenwei" sort="Liu, Chenwei" uniqKey="Liu C" first="Chenwei" last="Liu">Chenwei Liu</name>
<affiliation><nlm:aff id="A3">Core Genotyping Facility, National Cancer Institute, SAIC-Frederick, Inc., Gaithersburg, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
<affiliation><nlm:aff id="A25">University of Hawaii, Cancer Research Center</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Linet, Martha S" sort="Linet, Martha S" uniqKey="Linet M" first="Martha S." last="Linet">Martha S. Linet</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lonn, Stefan" sort="Lonn, Stefan" uniqKey="Lonn S" first="Stefan" last="Lonn">Stefan Lonn</name>
<affiliation><nlm:aff id="A12">Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A26">Medical Department, AstraZeneca Nordic, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name>
<affiliation><nlm:aff id="A27">Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A28">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Purdue, Mark P" sort="Purdue, Mark P" uniqKey="Purdue M" first="Mark P." last="Purdue">Mark P. Purdue</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ruder, Avima M" sort="Ruder, Avima M" uniqKey="Ruder A" first="Avima M." last="Ruder">Avima M. Ruder</name>
<affiliation><nlm:aff id="A14">National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sanson, Marc" sort="Sanson, Marc" uniqKey="Sanson M" first="Marc" last="Sanson">Marc Sanson</name>
<affiliation><nlm:aff id="A29">Service de Neurologie Mazarin, GH Pitié-Salpêtrière, APHP, and UMR 975 INSERM-UPMC, CRICM, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sesso, Howard D" sort="Sesso, Howard D" uniqKey="Sesso H" first="Howard D." last="Sesso">Howard D. Sesso</name>
<affiliation><nlm:aff id="A13">Division of Preventive Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation><nlm:aff id="A17">Massachusetts Veteran’s Epidemiology, Research and Information Center, Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Boston, MA, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A18">Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name>
<affiliation><nlm:aff id="A30">Vanderbilt University Medical Center, Nashville, TN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Simon, Matthias" sort="Simon, Matthias" uniqKey="Simon M" first="Matthias" last="Simon">Matthias Simon</name>
<affiliation><nlm:aff id="A31">Neurochirurgische Universitatsklinik, Bonn, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name>
<affiliation><nlm:aff id="A32">Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A33">Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L." last="Stevens">Victoria L. Stevens</name>
<affiliation><nlm:aff id="A16">Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Visvanathan, Kala" sort="Visvanathan, Kala" uniqKey="Visvanathan K" first="Kala" last="Visvanathan">Kala Visvanathan</name>
<affiliation><nlm:aff id="A21">Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A34">Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name>
<affiliation><nlm:aff id="A27">Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A28">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wolk, Alicja" sort="Wolk, Alicja" uniqKey="Wolk A" first="Alicja" last="Wolk">Alicja Wolk</name>
<affiliation><nlm:aff id="A35">Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zeleniuch Jacquotte, Anne" sort="Zeleniuch Jacquotte, Anne" uniqKey="Zeleniuch Jacquotte A" first="Anne" last="Zeleniuch-Jacquotte">Anne Zeleniuch-Jacquotte</name>
<affiliation><nlm:aff id="A36">Division of Epidemiology, Department of Environmental Medicine, NYU School of Medicine, New York, NY, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name>
<affiliation><nlm:aff id="A30">Vanderbilt University Medical Center, Nashville, TN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Decker, Paul" sort="Decker, Paul" uniqKey="Decker P" first="Paul" last="Decker">Paul Decker</name>
<affiliation><nlm:aff id="A10">Mayo Clinic, MN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Enciso Mora, Victor" sort="Enciso Mora, Victor" uniqKey="Enciso Mora V" first="Victor" last="Enciso-Mora">Victor Enciso-Mora</name>
<affiliation><nlm:aff id="A9">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fridley, Brooke" sort="Fridley, Brooke" uniqKey="Fridley B" first="Brooke" last="Fridley">Brooke Fridley</name>
<affiliation><nlm:aff id="A10">Mayo Clinic, MN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gao, Yu Tang" sort="Gao, Yu Tang" uniqKey="Gao Y" first="Yu-Tang" last="Gao">Yu-Tang Gao</name>
<affiliation><nlm:aff id="A37">Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kosel, Matt" sort="Kosel, Matt" uniqKey="Kosel M" first="Matt" last="Kosel">Matt Kosel</name>
<affiliation><nlm:aff id="A10">Mayo Clinic, MN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lachance, Dan" sort="Lachance, Dan" uniqKey="Lachance D" first="Dan" last="Lachance">Dan Lachance</name>
<affiliation><nlm:aff id="A10">Mayo Clinic, MN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lau, Ching" sort="Lau, Ching" uniqKey="Lau C" first="Ching" last="Lau">Ching Lau</name>
<affiliation><nlm:aff id="A8">Baylor College of Medicine, TX, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rice, Terri" sort="Rice, Terri" uniqKey="Rice T" first="Terri" last="Rice">Terri Rice</name>
<affiliation><nlm:aff id="A11">University of California San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name>
<affiliation><nlm:aff id="A9">Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A38">Division of Breast Cancer Research, Institute of Cancer Research , London, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wiemels, Joe" sort="Wiemels, Joe" uniqKey="Wiemels J" first="Joe" last="Wiemels">Joe Wiemels</name>
<affiliation><nlm:aff id="A11">University of California San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wiencke, John" sort="Wiencke, John" uniqKey="Wiencke J" first="John" last="Wiencke">John Wiencke</name>
<affiliation><nlm:aff id="A11">University of California San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shete, Sanjay" sort="Shete, Sanjay" uniqKey="Shete S" first="Sanjay" last="Shete">Sanjay Shete</name>
<affiliation><nlm:aff id="A39">Department of Biostatistics, MD Anderson Cancer Center, TX, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Xiang, Yong Bing" sort="Xiang, Yong Bing" uniqKey="Xiang Y" first="Yong-Bing" last="Xiang">Yong-Bing Xiang</name>
<affiliation><nlm:aff id="A37">Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Xiao, Yuanyuan" sort="Xiao, Yuanyuan" uniqKey="Xiao Y" first="Yuanyuan" last="Xiao">Yuanyuan Xiao</name>
<affiliation><nlm:aff id="A11">University of California San Francisco, CA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hoover, Robert" sort="Hoover, Robert" uniqKey="Hoover R" first="Robert" last="Hoover">Robert Hoover</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fraumeni, Joseph F" sort="Fraumeni, Joseph F" uniqKey="Fraumeni J" first="Joseph F." last="Fraumeni">Joseph F. Fraumeni</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Core Genotyping Facility, National Cancer Institute, SAIC-Frederick, Inc., Gaithersburg, MD, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Human genetics</title>
<idno type="ISSN">0340-6717</idno>
<idno type="eISSN">1432-1203</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><p id="P3">Gliomas account for approximately 80% of all primary malignant brain tumors, and despite improvements in clinical care over the last 20 years remain among the most lethal tumors, underscoring the need for gaining new insights that could translate into clinical advances. Recent genome-wide association studies (GWAS) have identified seven new susceptibility regions. We conducted a new independent GWAS of glioma using 1,856 cases and 4,955 controls (from 14 cohort studies, 3 casecontrol studies, and 1 population-based case only study) and found evidence of strong replication for three of the seven previously reported associations at 20q13.33 (<italic>RTEL</italic>
), 5p15.33 (<italic>TERT</italic>
), and 9p21.3 (<italic>CDKN2BAS</italic>
), and consistent association signals for the remaining four at 7p11.2 (<italic>EGFR</italic>
both loci), 8q24.21 (<italic>CCDC26</italic>
) and 11q23.3 (<italic>PHLDB1</italic>
). The direction and magnitude of the signal were consistent for samples from cohort and case-control studies, but the strength of the association was more pronounced for loci rs6010620 (20q,13.33; <italic>RTEL</italic>
) and rs2736100 (5p15.33, <italic>TERT</italic>
) in cohort studies despite the smaller number of cases in this group, likely due to relatively more higher grade tumors being captured in the cohort studies. We further examined the 85 most promising single nucleotide polymorphism (SNP) markers identified in our study in three replication sets (5,015 cases and 11,601 controls), but no new markers reached genome-wide significance. Our findings suggest that larger studies focusing on novel approaches as well as specific tumor subtypes or subgroups will be required to identify additional common susceptibility loci for glioma risk.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7613873</journal-id>
<journal-id journal-id-type="pubmed-jr-id">4137</journal-id>
<journal-id journal-id-type="nlm-ta">Hum Genet</journal-id>
<journal-id journal-id-type="iso-abbrev">Hum. Genet.</journal-id>
<journal-title-group><journal-title>Human genetics</journal-title>
</journal-title-group>
<issn pub-type="ppub">0340-6717</issn>
<issn pub-type="epub">1432-1203</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22886559</article-id>
<article-id pub-id-type="pmc">3761216</article-id>
<article-id pub-id-type="doi">10.1007/s00439-012-1212-0</article-id>
<article-id pub-id-type="manuscript">NIHMS473795</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Genome-wide Association Study of Glioma and Meta-Analysis</article-title>
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</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</aff>
<aff id="A2"><label>2</label>
Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden</aff>
<aff id="A3"><label>3</label>
Core Genotyping Facility, National Cancer Institute, SAIC-Frederick, Inc., Gaithersburg, MD, USA</aff>
<aff id="A4"><label>4</label>
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</aff>
<aff id="A5"><label>5</label>
Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, RI, USA</aff>
<aff id="A6"><label>6</label>
School of Public Health, Imperial College London, London, UK</aff>
<aff id="A7"><label>7</label>
Division of Cancer Etiology, Department of Population Sciences, City of Hope and the Beckman Research Institute, Duarte, CA, USA</aff>
<aff id="A8"><label>8</label>
Baylor College of Medicine, TX, USA</aff>
<aff id="A9"><label>9</label>
Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK</aff>
<aff id="A10"><label>10</label>
Mayo Clinic, MN, USA</aff>
<aff id="A11"><label>11</label>
University of California San Francisco, CA, USA</aff>
<aff id="A12"><label>12</label>
Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</aff>
<aff id="A13"><label>13</label>
Division of Preventive Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA USA</aff>
<aff id="A14"><label>14</label>
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA</aff>
<aff id="A15"><label>15</label>
Division of Biostatistics, University of Leeds, UK</aff>
<aff id="A16"><label>16</label>
Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA</aff>
<aff id="A17"><label>17</label>
Massachusetts Veteran’s Epidemiology, Research and Information Center, Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Boston, MA, USA</aff>
<aff id="A18"><label>18</label>
Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Australia</aff>
<aff id="A19"><label>19</label>
Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia</aff>
<aff id="A20"><label>20</label>
Department of Public Health and Clinical Medicine/Nutritional Research, Umeå University, Umeå, Sweden</aff>
<aff id="A21"><label>21</label>
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA</aff>
<aff id="A22"><label>22</label>
The Danish Cancer Society Research Center, Unit of Survivorship, Copenhagen, Denmark</aff>
<aff id="A23"><label>23</label>
Centre National de Genotypage, IG/CEA, Evry Cedex, France</aff>
<aff id="A24"><label>24</label>
Foundation Jean Dauset-CEPH, Paris, France</aff>
<aff id="A25"><label>25</label>
University of Hawaii, Cancer Research Center</aff>
<aff id="A26"><label>26</label>
Medical Department, AstraZeneca Nordic, Sweden</aff>
<aff id="A27"><label>27</label>
Fred Hutchinson Cancer Research Center, Seattle, WA, USA</aff>
<aff id="A28"><label>28</label>
Department of Epidemiology, University of Washington, Seattle, WA, USA</aff>
<aff id="A29"><label>29</label>
Service de Neurologie Mazarin, GH Pitié-Salpêtrière, APHP, and UMR 975 INSERM-UPMC, CRICM, Paris, France</aff>
<aff id="A30"><label>30</label>
Vanderbilt University Medical Center, Nashville, TN, USA</aff>
<aff id="A31"><label>31</label>
Neurochirurgische Universitatsklinik, Bonn, Germany</aff>
<aff id="A32"><label>32</label>
Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA</aff>
<aff id="A33"><label>33</label>
Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA, USA</aff>
<aff id="A34"><label>34</label>
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA</aff>
<aff id="A35"><label>35</label>
Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</aff>
<aff id="A36"><label>36</label>
Division of Epidemiology, Department of Environmental Medicine, NYU School of Medicine, New York, NY, USA</aff>
<aff id="A37"><label>37</label>
Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China</aff>
<aff id="A38"><label>38</label>
Division of Breast Cancer Research, Institute of Cancer Research , London, UK</aff>
<aff id="A39"><label>39</label>
Department of Biostatistics, MD Anderson Cancer Center, TX, USA</aff>
<author-notes><corresp id="CR1"><bold>Address for Correspondence</bold>
: Preetha Rajaraman REB, National Cancer Institute, NIH, DHHS 6120 Executive Blvd, EPS Room 7058 Bethesda, MD 20892-7238 Tel: (301) 654-1088 <email>rajarama@mail.nih.gov</email>
</corresp>
<fn fn-type="equal" id="FN1"><label>*</label>
<p id="P1">These authors contributed equally to this work</p>
</fn>
<fn id="FN2"><label>**</label>
<p id="P2">The authors jointly directed this work</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>30</day>
<month>7</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>11</day>
<month>8</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="ppub"><month>12</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>04</day>
<month>9</month>
<year>2013</year>
</pub-date>
<volume>131</volume>
<issue>12</issue>
<fpage>1877</fpage>
<lpage>1888</lpage>
<abstract><p id="P3">Gliomas account for approximately 80% of all primary malignant brain tumors, and despite improvements in clinical care over the last 20 years remain among the most lethal tumors, underscoring the need for gaining new insights that could translate into clinical advances. Recent genome-wide association studies (GWAS) have identified seven new susceptibility regions. We conducted a new independent GWAS of glioma using 1,856 cases and 4,955 controls (from 14 cohort studies, 3 casecontrol studies, and 1 population-based case only study) and found evidence of strong replication for three of the seven previously reported associations at 20q13.33 (<italic>RTEL</italic>
), 5p15.33 (<italic>TERT</italic>
), and 9p21.3 (<italic>CDKN2BAS</italic>
), and consistent association signals for the remaining four at 7p11.2 (<italic>EGFR</italic>
both loci), 8q24.21 (<italic>CCDC26</italic>
) and 11q23.3 (<italic>PHLDB1</italic>
). The direction and magnitude of the signal were consistent for samples from cohort and case-control studies, but the strength of the association was more pronounced for loci rs6010620 (20q,13.33; <italic>RTEL</italic>
) and rs2736100 (5p15.33, <italic>TERT</italic>
) in cohort studies despite the smaller number of cases in this group, likely due to relatively more higher grade tumors being captured in the cohort studies. We further examined the 85 most promising single nucleotide polymorphism (SNP) markers identified in our study in three replication sets (5,015 cases and 11,601 controls), but no new markers reached genome-wide significance. Our findings suggest that larger studies focusing on novel approaches as well as specific tumor subtypes or subgroups will be required to identify additional common susceptibility loci for glioma risk.</p>
</abstract>
<funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
<award-id>R01 CA114205 || CA</award-id>
</award-group>
<award-group><funding-source country="United States">Division of Cancer Epidemiology and Genetics : NCI</funding-source>
<award-id>Z01 CP010132-12 || CP</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>
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