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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG)</title><author><name sortKey="Jin, Guangfu" sort="Jin, Guangfu" uniqKey="Jin G" first="Guangfu" last="Jin">Guangfu Jin</name></author><author><name sortKey="Lu, Lingyi" sort="Lu, Lingyi" uniqKey="Lu L" first="Lingyi" last="Lu">Lingyi Lu</name></author><author><name sortKey="Cooney, Kathleen A" sort="Cooney, Kathleen A" uniqKey="Cooney K" first="Kathleen A." last="Cooney">Kathleen A. Cooney</name></author><author><name sortKey="Ray, Anna M" sort="Ray, Anna M" uniqKey="Ray A" first="Anna M." last="Ray">Anna M. Ray</name></author><author><name sortKey="Zuhlke, Kimberly A" sort="Zuhlke, Kimberly A" uniqKey="Zuhlke K" first="Kimberly A." last="Zuhlke">Kimberly A. Zuhlke</name></author><author><name sortKey="Lange, Ethan M" sort="Lange, Ethan M" uniqKey="Lange E" first="Ethan M." last="Lange">Ethan M. Lange</name></author><author><name sortKey="Cannon Albright, Lisa A" sort="Cannon Albright, Lisa A" uniqKey="Cannon Albright L" first="Lisa A." last="Cannon-Albright">Lisa A. Cannon-Albright</name></author><author><name sortKey="Camp, Nicola J" sort="Camp, Nicola J" uniqKey="Camp N" first="Nicola J." last="Camp">Nicola J. Camp</name></author><author><name sortKey="Teerlink, Craig C" sort="Teerlink, Craig C" uniqKey="Teerlink C" first="Craig C." last="Teerlink">Craig C. Teerlink</name></author><author><name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M." last="Fitzgerald">Liesel M. Fitzgerald</name></author><author><name sortKey="Stanford, Janet L" sort="Stanford, Janet L" uniqKey="Stanford J" first="Janet L." last="Stanford">Janet L. Stanford</name></author><author><name sortKey="Wiley, Kathleen E" sort="Wiley, Kathleen E" uniqKey="Wiley K" first="Kathleen E." last="Wiley">Kathleen E. Wiley</name></author><author><name sortKey="Isaacs, Sarah D" sort="Isaacs, Sarah D" uniqKey="Isaacs S" first="Sarah D." last="Isaacs">Sarah D. Isaacs</name></author><author><name sortKey="Walsh, Patrick C" sort="Walsh, Patrick C" uniqKey="Walsh P" first="Patrick C." last="Walsh">Patrick C. Walsh</name></author><author><name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D." last="Foulkes">William D. Foulkes</name></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name></author><author><name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name></author><author><name sortKey="Easton, Doug" sort="Easton, Doug" uniqKey="Easton D" first="Doug" last="Easton">Doug Easton</name></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name></author><author><name sortKey="Guy, Michelle" sort="Guy, Michelle" uniqKey="Guy M" first="Michelle" last="Guy">Michelle Guy</name></author><author><name sortKey="Rinckleb, Antje" sort="Rinckleb, Antje" uniqKey="Rinckleb A" first="Antje" last="Rinckleb">Antje Rinckleb</name></author><author><name sortKey="Maier, Christiane" sort="Maier, Christiane" uniqKey="Maier C" first="Christiane" last="Maier">Christiane Maier</name></author><author><name sortKey="Vogel, Walther" sort="Vogel, Walther" uniqKey="Vogel W" first="Walther" last="Vogel">Walther Vogel</name></author><author><name sortKey="Cancel Tassin, Geraldine" sort="Cancel Tassin, Geraldine" uniqKey="Cancel Tassin G" first="Geraldine" last="Cancel-Tassin">Geraldine Cancel-Tassin</name></author><author><name sortKey="Egrot, Christophe" sort="Egrot, Christophe" uniqKey="Egrot C" first="Christophe" last="Egrot">Christophe Egrot</name></author><author><name sortKey="Cussenot, Olivier" sort="Cussenot, Olivier" uniqKey="Cussenot O" first="Olivier" last="Cussenot">Olivier Cussenot</name></author><author><name sortKey="Thibodeau, Stephen N" sort="Thibodeau, Stephen N" uniqKey="Thibodeau S" first="Stephen N." last="Thibodeau">Stephen N. Thibodeau</name></author><author><name sortKey="Mcdonnell, Shannon K" sort="Mcdonnell, Shannon K" uniqKey="Mcdonnell S" first="Shannon K." last="Mcdonnell">Shannon K. Mcdonnell</name></author><author><name sortKey="Schaid, Daniel J" sort="Schaid, Daniel J" uniqKey="Schaid D" first="Daniel J." last="Schaid">Daniel J. Schaid</name></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name></author><author><name sortKey="Emanuelsson, Monica" sort="Emanuelsson, Monica" uniqKey="Emanuelsson M" first="Monica" last="Emanuelsson">Monica Emanuelsson</name></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name></author><author><name sortKey="Oakley Girvan, Ingrid" sort="Oakley Girvan, Ingrid" uniqKey="Oakley Girvan I" first="Ingrid" last="Oakley-Girvan">Ingrid Oakley-Girvan</name></author><author><name sortKey="Hsieh, Chih Lin" sort="Hsieh, Chih Lin" uniqKey="Hsieh C" first="Chih-Lin" last="Hsieh">Chih-Lin Hsieh</name></author><author><name sortKey="Wahlfors, Tiina" sort="Wahlfors, Tiina" uniqKey="Wahlfors T" first="Tiina" last="Wahlfors">Tiina Wahlfors</name></author><author><name sortKey="Tammela, Teuvo" sort="Tammela, Teuvo" uniqKey="Tammela T" first="Teuvo" last="Tammela">Teuvo Tammela</name></author><author><name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name></author><author><name sortKey="Catalona, William J" sort="Catalona, William J" uniqKey="Catalona W" first="William J." last="Catalona">William J. Catalona</name></author><author><name sortKey="Zheng, S Lilly" sort="Zheng, S Lilly" uniqKey="Zheng S" first="S. Lilly" last="Zheng">S. Lilly Zheng</name></author><author><name sortKey="Ostrander, Elaine A" sort="Ostrander, Elaine A" uniqKey="Ostrander E" first="Elaine A." last="Ostrander">Elaine A. Ostrander</name></author><author><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name></author><author><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22198737</idno><idno type="pmc">3535428</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535428</idno><idno type="RBID">PMC:3535428</idno><idno type="doi">10.1007/s00439-011-1136-0</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001F65</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F65</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG)</title><author><name sortKey="Jin, Guangfu" sort="Jin, Guangfu" uniqKey="Jin G" first="Guangfu" last="Jin">Guangfu Jin</name></author><author><name sortKey="Lu, Lingyi" sort="Lu, Lingyi" uniqKey="Lu L" first="Lingyi" last="Lu">Lingyi Lu</name></author><author><name sortKey="Cooney, Kathleen A" sort="Cooney, Kathleen A" uniqKey="Cooney K" first="Kathleen A." last="Cooney">Kathleen A. Cooney</name></author><author><name sortKey="Ray, Anna M" sort="Ray, Anna M" uniqKey="Ray A" first="Anna M." last="Ray">Anna M. Ray</name></author><author><name sortKey="Zuhlke, Kimberly A" sort="Zuhlke, Kimberly A" uniqKey="Zuhlke K" first="Kimberly A." last="Zuhlke">Kimberly A. Zuhlke</name></author><author><name sortKey="Lange, Ethan M" sort="Lange, Ethan M" uniqKey="Lange E" first="Ethan M." last="Lange">Ethan M. Lange</name></author><author><name sortKey="Cannon Albright, Lisa A" sort="Cannon Albright, Lisa A" uniqKey="Cannon Albright L" first="Lisa A." last="Cannon-Albright">Lisa A. Cannon-Albright</name></author><author><name sortKey="Camp, Nicola J" sort="Camp, Nicola J" uniqKey="Camp N" first="Nicola J." last="Camp">Nicola J. Camp</name></author><author><name sortKey="Teerlink, Craig C" sort="Teerlink, Craig C" uniqKey="Teerlink C" first="Craig C." last="Teerlink">Craig C. Teerlink</name></author><author><name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M." last="Fitzgerald">Liesel M. Fitzgerald</name></author><author><name sortKey="Stanford, Janet L" sort="Stanford, Janet L" uniqKey="Stanford J" first="Janet L." last="Stanford">Janet L. Stanford</name></author><author><name sortKey="Wiley, Kathleen E" sort="Wiley, Kathleen E" uniqKey="Wiley K" first="Kathleen E." last="Wiley">Kathleen E. Wiley</name></author><author><name sortKey="Isaacs, Sarah D" sort="Isaacs, Sarah D" uniqKey="Isaacs S" first="Sarah D." last="Isaacs">Sarah D. Isaacs</name></author><author><name sortKey="Walsh, Patrick C" sort="Walsh, Patrick C" uniqKey="Walsh P" first="Patrick C." last="Walsh">Patrick C. Walsh</name></author><author><name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D." last="Foulkes">William D. Foulkes</name></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name></author><author><name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name></author><author><name sortKey="Easton, Doug" sort="Easton, Doug" uniqKey="Easton D" first="Doug" last="Easton">Doug Easton</name></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name></author><author><name sortKey="Guy, Michelle" sort="Guy, Michelle" uniqKey="Guy M" first="Michelle" last="Guy">Michelle Guy</name></author><author><name sortKey="Rinckleb, Antje" sort="Rinckleb, Antje" uniqKey="Rinckleb A" first="Antje" last="Rinckleb">Antje Rinckleb</name></author><author><name sortKey="Maier, Christiane" sort="Maier, Christiane" uniqKey="Maier C" first="Christiane" last="Maier">Christiane Maier</name></author><author><name sortKey="Vogel, Walther" sort="Vogel, Walther" uniqKey="Vogel W" first="Walther" last="Vogel">Walther Vogel</name></author><author><name sortKey="Cancel Tassin, Geraldine" sort="Cancel Tassin, Geraldine" uniqKey="Cancel Tassin G" first="Geraldine" last="Cancel-Tassin">Geraldine Cancel-Tassin</name></author><author><name sortKey="Egrot, Christophe" sort="Egrot, Christophe" uniqKey="Egrot C" first="Christophe" last="Egrot">Christophe Egrot</name></author><author><name sortKey="Cussenot, Olivier" sort="Cussenot, Olivier" uniqKey="Cussenot O" first="Olivier" last="Cussenot">Olivier Cussenot</name></author><author><name sortKey="Thibodeau, Stephen N" sort="Thibodeau, Stephen N" uniqKey="Thibodeau S" first="Stephen N." last="Thibodeau">Stephen N. Thibodeau</name></author><author><name sortKey="Mcdonnell, Shannon K" sort="Mcdonnell, Shannon K" uniqKey="Mcdonnell S" first="Shannon K." last="Mcdonnell">Shannon K. Mcdonnell</name></author><author><name sortKey="Schaid, Daniel J" sort="Schaid, Daniel J" uniqKey="Schaid D" first="Daniel J." last="Schaid">Daniel J. Schaid</name></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name></author><author><name sortKey="Emanuelsson, Monica" sort="Emanuelsson, Monica" uniqKey="Emanuelsson M" first="Monica" last="Emanuelsson">Monica Emanuelsson</name></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name></author><author><name sortKey="Oakley Girvan, Ingrid" sort="Oakley Girvan, Ingrid" uniqKey="Oakley Girvan I" first="Ingrid" last="Oakley-Girvan">Ingrid Oakley-Girvan</name></author><author><name sortKey="Hsieh, Chih Lin" sort="Hsieh, Chih Lin" uniqKey="Hsieh C" first="Chih-Lin" last="Hsieh">Chih-Lin Hsieh</name></author><author><name sortKey="Wahlfors, Tiina" sort="Wahlfors, Tiina" uniqKey="Wahlfors T" first="Tiina" last="Wahlfors">Tiina Wahlfors</name></author><author><name sortKey="Tammela, Teuvo" sort="Tammela, Teuvo" uniqKey="Tammela T" first="Teuvo" last="Tammela">Teuvo Tammela</name></author><author><name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name></author><author><name sortKey="Catalona, William J" sort="Catalona, William J" uniqKey="Catalona W" first="William J." last="Catalona">William J. Catalona</name></author><author><name sortKey="Zheng, S Lilly" sort="Zheng, S Lilly" uniqKey="Zheng S" first="S. Lilly" last="Zheng">S. Lilly Zheng</name></author><author><name sortKey="Ostrander, Elaine A" sort="Ostrander, Elaine A" uniqKey="Ostrander E" first="Elaine A." last="Ostrander">Elaine A. Ostrander</name></author><author><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name></author><author><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name></author></analytic><series><title level="j">Human genetics</title><idno type="ISSN">0340-6717</idno><idno type="eISSN">1432-1203</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Multiple prostate cancer (PCa) risk-related loci have been discovered by genome-wide association studies (GWAS) based on case–control designs. However, GWAS findings may be confounded by population stratification if cases and controls are inadvertently drawn from different genetic backgrounds. In addition, since these loci were identified in cases with predominantly sporadic disease, little is known about their relationships with hereditary prostate cancer (HPC). The association between seventeen reported PCa susceptibility loci was evaluated with a family-based association test using 1,979 hereditary PCa families of European descent collected by members of the International Consortium for Prostate Cancer Genetics, with a total of 5,730 affected men. The risk alleles for 8 of the 17 loci were significantly over-transmitted from parents to affected offspring, including SNPs residing in 8q24 (regions 1, 2 and 3), 10q11, 11q13, 17q12 (region 1), 17q24 and Xp11. In subgroup analyses, three loci, at 8q24 (regions 1 and 2) plus 17q12, were significantly over-transmitted in hereditary PCa families with five or more affected members, while loci at 3p12, 8q24 (region 2), 11q13, 17q12 (region 1), 17q24 and Xp11 were significantly over-transmitted in HPC families with an average age of diagnosis at 65 years or less. Our results indicate that at least a subset of PCa risk-related loci identified by case–control GWAS are also associated with disease risk in HPC families.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7613873</journal-id><journal-id journal-id-type="pubmed-jr-id">4137</journal-id><journal-id journal-id-type="nlm-ta">Hum Genet</journal-id><journal-id journal-id-type="iso-abbrev">Hum. Genet.</journal-id><journal-title-group><journal-title>Human genetics</journal-title></journal-title-group><issn pub-type="ppub">0340-6717</issn><issn pub-type="epub">1432-1203</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22198737</article-id><article-id pub-id-type="pmc">3535428</article-id><article-id pub-id-type="doi">10.1007/s00439-011-1136-0</article-id><article-id pub-id-type="manuscript">NIHMS403275</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Jin</surname><given-names>Guangfu</given-names></name><aff id="A1">Data Coordinating Center for the ICPCG and Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem NC 27157, USA</aff></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>Lingyi</given-names></name><aff id="A2">Data Coordinating Center for the ICPCG and Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem NC 27157, USA</aff></contrib><contrib contrib-type="author"><name><surname>Cooney</surname><given-names>Kathleen A.</given-names></name><aff id="A3">Departments of Internal Medicine and Urology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA. University of Michigan ICPCG Group, Ann Arbor, USA</aff></contrib><contrib contrib-type="author"><name><surname>Ray</surname><given-names>Anna M.</given-names></name><aff id="A4">Departments of Internal Medicine and Urology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA. University of Michigan ICPCG Group, Ann Arbor, USA</aff></contrib><contrib contrib-type="author"><name><surname>Zuhlke</surname><given-names>Kimberly A.</given-names></name><aff id="A5">Departments of Internal Medicine and Urology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA. University of Michigan ICPCG Group, Ann Arbor, USA</aff></contrib><contrib contrib-type="author"><name><surname>Lange</surname><given-names>Ethan M.</given-names></name><aff id="A6">Departments of Genetics and Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA</aff></contrib><contrib contrib-type="author"><name><surname>Cannon-Albright</surname><given-names>Lisa A.</given-names></name><aff id="A7">University of Utah ICPCG Group, Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108, USA. George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT 84148, USA. University of Michigan ICPCG Group, Ann Arbor, USA</aff></contrib><contrib contrib-type="author"><name><surname>Camp</surname><given-names>Nicola J.</given-names></name><aff id="A8">University of Utah ICPCG Group, Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108, USA</aff></contrib><contrib contrib-type="author"><name><surname>Teerlink</surname><given-names>Craig C.</given-names></name><aff id="A9">University of Utah ICPCG Group, Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108, USA</aff></contrib><contrib contrib-type="author"><name><surname>FitzGerald</surname><given-names>Liesel M.</given-names></name><aff id="A10">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, WA 98195, USA</aff></contrib><contrib contrib-type="author"><name><surname>Stanford</surname><given-names>Janet L.</given-names></name><aff id="A11">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, WA 98195, USA</aff></contrib><contrib contrib-type="author"><name><surname>Wiley</surname><given-names>Kathleen E.</given-names></name><aff id="A12">Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA</aff></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Isaacs</surname><given-names>Sarah D.</given-names></name><aff id="A13">Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA</aff><email>wisaacs@jhmi.edu</email></contrib><contrib contrib-type="author"><name><surname>Walsh</surname><given-names>Patrick C.</given-names></name><aff id="A14">Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA</aff></contrib><contrib contrib-type="author"><name><surname>Foulkes</surname><given-names>William D.</given-names></name><aff id="A15">Program in Cancer Genetics, McGill University, Montreal, QC H3T 1E2, Canada</aff></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham G.</given-names></name><aff id="A16">Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, VIC 3053, Australia. Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, VIC 3010, Australia</aff></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L.</given-names></name><aff id="A17">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, VIC 3010, Australia</aff></contrib><contrib contrib-type="author"><name><surname>Severi</surname><given-names>Gianluca</given-names></name><aff id="A18">Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, VIC 3053, Australia. Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, VIC 3010, Australia</aff></contrib><contrib contrib-type="author"><name><surname>Eeles</surname><given-names>Ros</given-names></name><aff id="A19">The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK</aff></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Doug</given-names></name><aff id="A20">Departments of Public Health and Primary Care and Oncology, University of Cambridge, Cambridge CB1 8RN, UK</aff></contrib><contrib contrib-type="author"><name><surname>Kote-Jarai</surname><given-names>Zsofia</given-names></name><aff id="A21">The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK</aff></contrib><contrib contrib-type="author"><name><surname>Guy</surname><given-names>Michelle</given-names></name><aff id="A22">The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK</aff></contrib><contrib contrib-type="author"><name><surname>Rinckleb</surname><given-names>Antje</given-names></name><aff id="A23">Department of Urology, University of Ulm, Ulm, Germany. Institute for Human Genetics, University of Ulm, Ulm, Germany</aff></contrib><contrib contrib-type="author"><name><surname>Maier</surname><given-names>Christiane</given-names></name><aff id="A24">Department of Urology, University of Ulm, Ulm, Germany. Institute for Human Genetics, University of Ulm, Ulm, Germany</aff></contrib><contrib contrib-type="author"><name><surname>Vogel</surname><given-names>Walther</given-names></name><aff id="A25">Institute for Human Genetics, University of Ulm, Ulm, Germany</aff></contrib><contrib contrib-type="author"><name><surname>Cancel-Tassin</surname><given-names>Geraldine</given-names></name><aff id="A26">CeRePP ICPCG Group, Hopital Tenon, Assistance Publique-Hopitaux de Paris, 75020 Paris, France</aff></contrib><contrib contrib-type="author"><name><surname>Egrot</surname><given-names>Christophe</given-names></name><aff id="A27">CeRePP ICPCG Group, Hopital Tenon, Assistance Publique-Hopitaux de Paris, 75020 Paris, France</aff></contrib><contrib contrib-type="author"><name><surname>Cussenot</surname><given-names>Olivier</given-names></name><aff id="A28">CeRePP ICPCG Group, Hopital Tenon, Assistance Publique-Hopitaux de Paris, 75020 Paris, France</aff></contrib><contrib contrib-type="author"><name><surname>Thibodeau</surname><given-names>Stephen N.</given-names></name><aff id="A29">Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</aff></contrib><contrib contrib-type="author"><name><surname>McDonnell</surname><given-names>Shannon K.</given-names></name><aff id="A30">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</aff></contrib><contrib contrib-type="author"><name><surname>Schaid</surname><given-names>Daniel J.</given-names></name><aff id="A31">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</aff></contrib><contrib contrib-type="author"><name><surname>Wiklund</surname><given-names>Fredrik</given-names></name><aff id="A32">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff></contrib><contrib contrib-type="author"><name><surname>Grönberg</surname><given-names>Henrik</given-names></name><aff id="A33">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff></contrib><contrib contrib-type="author"><name><surname>Emanuelsson</surname><given-names>Monica</given-names></name><aff id="A34">Oncologic Centre, Umeå University, 90187 Umeå, Sweden</aff></contrib><contrib contrib-type="author"><name><surname>Whittemore</surname><given-names>Alice S.</given-names></name><aff id="A35">Department of Health Research and Policy, Stanford School of Medicine, Stanford, CA 94305, USA</aff></contrib><contrib contrib-type="author"><name><surname>Oakley-Girvan</surname><given-names>Ingrid</given-names></name><aff id="A36">Cancer Prevention Institute of California, 2201 Walnut Ave Suite 300, Fremont, CA 94538, USA. Department of Health Research and Policy, Stanford Cancer Institute, Stanford School of Medicine, Stanford, CA 94305, USA</aff></contrib><contrib contrib-type="author"><name><surname>Hsieh</surname><given-names>Chih-Lin</given-names></name><aff id="A37">Department of Urology, University of Southern California, Los Angeles, CA 90089, USA. Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA 90089, USA</aff></contrib><contrib contrib-type="author"><name><surname>Wahlfors</surname><given-names>Tiina</given-names></name><aff id="A38">Institute of Biomedical Technology, University of Tampere, BioMediTech, Tampere, Finland. Centre for Laboratory Medicine, Tampere University Hospital, 33520 Tampere, Finland</aff></contrib><contrib contrib-type="author"><name><surname>Tammela</surname><given-names>Teuvo</given-names></name><aff id="A39">Department of Urology, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland</aff></contrib><contrib contrib-type="author"><name><surname>Schleutker</surname><given-names>Johanna</given-names></name><aff id="A40">Department of Medical Biochemistry and Genetics, University of Turku, 20014 Turku, Finland</aff></contrib><contrib contrib-type="author"><name><surname>Catalona</surname><given-names>William J.</given-names></name><aff id="A41">Northwestern University ICPCG Group, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA</aff></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>S. Lilly</given-names></name><aff id="A42">Data Coordinating Center for the ICPCG and Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem NC 27157, USA</aff></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Ostrander</surname><given-names>Elaine A.</given-names></name><aff id="A43">Cancer Genetics Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD 20892, USA</aff><email>eostrand@mail.nih.gov</email></contrib><contrib contrib-type="author"><name><surname>Isaacs</surname><given-names>William B.</given-names></name><aff id="A44">Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA</aff></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Xu</surname><given-names>Jianfeng</given-names></name><aff id="A45">Data Coordinating Center for the ICPCG and Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem NC 27157, USA</aff><email>jxu@wakehealth.edu</email></contrib><contrib contrib-type="author"><collab>International Consortium for Prostate Cancer Genetics</collab></contrib></contrib-group><author-notes><fn id="FN1" fn-type="equal"><p>G. Jin and L. Lu contributed equally to this work.</p></fn><fn id="FN2"><p>K.A. Cooney, A.M. Ray, K.A. Zuhlke and E.M. Lange are the members of the University of Michigan ICPCG Group.</p><p>L.M. FitzGerald and J.L. Stanford are the members of the FHCRC/NHGRI ICPCG Group.</p><p>W.D. Foulkes, G.G. Giles, J.L. Hopper, G. Severi, R. Eeles, D. Easton, Z. Kote-Jarai, and M. Guy are the members of the ACTANE Consortium ICPCG Group.</p><p>A. Rinckleb, C. Maier and W. Vogel are the members of the University of Ulm ICPCG Group.</p><p>S.N. Thibodeau, S.K. McDonnell and D.J. Schaid are the members of the Mayo Clinic ICPCG Group.</p><p>F. Wiklund, H. Grönberg and M. Emanuelsson are the members of the University of Umeå ICPCG Group.</p><p>A.S. Whittemore, I. Oakley-Girvan and C.-L. Hsieh are the members of the BC/CA/HI ICPCG Group.</p><p>T. Wahlfors, T. Tammela and J. Schleutker are the members of the University of Tampere ICPCG Group.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>27</day><month>8</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>25</day><month>12</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>03</day><month>1</month><year>2013</year></pub-date><volume>131</volume><issue>7</issue><fpage>1095</fpage><lpage>1103</lpage><permissions><copyright-statement>© Springer-Verlag 2011</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><p id="P1">Multiple prostate cancer (PCa) risk-related loci have been discovered by genome-wide association studies (GWAS) based on case–control designs. However, GWAS findings may be confounded by population stratification if cases and controls are inadvertently drawn from different genetic backgrounds. In addition, since these loci were identified in cases with predominantly sporadic disease, little is known about their relationships with hereditary prostate cancer (HPC). The association between seventeen reported PCa susceptibility loci was evaluated with a family-based association test using 1,979 hereditary PCa families of European descent collected by members of the International Consortium for Prostate Cancer Genetics, with a total of 5,730 affected men. The risk alleles for 8 of the 17 loci were significantly over-transmitted from parents to affected offspring, including SNPs residing in 8q24 (regions 1, 2 and 3), 10q11, 11q13, 17q12 (region 1), 17q24 and Xp11. In subgroup analyses, three loci, at 8q24 (regions 1 and 2) plus 17q12, were significantly over-transmitted in hereditary PCa families with five or more affected members, while loci at 3p12, 8q24 (region 2), 11q13, 17q12 (region 1), 17q24 and Xp11 were significantly over-transmitted in HPC families with an average age of diagnosis at 65 years or less. Our results indicate that at least a subset of PCa risk-related loci identified by case–control GWAS are also associated with disease risk in HPC families.</p></abstract><funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U01 CA089600 || CA</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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