Echocardiographic Findings Predict In-Hospital and One-Year Mortality in Left-Sided Native Valve Staphylococcus aureus Endocarditis: An Analysis from The International Collaboration on Endocarditis-Prospective Echo Cohort Study
Identifieur interne : 001E55 ( Pmc/Corpus ); précédent : 001E54; suivant : 001E56Echocardiographic Findings Predict In-Hospital and One-Year Mortality in Left-Sided Native Valve Staphylococcus aureus Endocarditis: An Analysis from The International Collaboration on Endocarditis-Prospective Echo Cohort Study
Auteurs : Trine K. Lauridsen ; Lawrence Park ; Steven Y. C. Tong ; Christine Selton-Suty ; Gail Peterson ; Enrico Cecchi ; Luis Afonso ; Gilbert Habib ; Carlos Paré ; Syahidah Tamin ; Stuart Dickerman ; Arnold S. Bayer ; Magnus C. Johansson ; Vivian H. Chu ; Zainab Samad ; Niels E. Bruun ; Vance G. Fowler ; Anna Lisa CrowleySource :
- Circulation. Cardiovascular imaging [ 1941-9651 ] ; 2015.
Abstract
Consecutive patients with LNVIE, enrolled between January 2000 and September 2006, in the International Collaboration on Endocarditis were identified. Subjects without
Url:
DOI: 10.1161/CIRCIMAGING.114.003397
PubMed: 26162783
PubMed Central: 4503384
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Echocardiographic Findings Predict In-Hospital and One-Year Mortality in Left-Sided Native Valve <italic>Staphylococcus aureus</italic> Endocarditis: An Analysis from The International Collaboration on Endocarditis-Prospective Echo Cohort Study</title><author><name sortKey="Lauridsen, Trine K" sort="Lauridsen, Trine K" uniqKey="Lauridsen T" first="Trine K." last="Lauridsen">Trine K. Lauridsen</name><affiliation><nlm:aff id="A1">Department of Medicine, Duke University, Durham, NC</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Cardiology, Gentofte University, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Park, Lawrence" sort="Park, Lawrence" uniqKey="Park L" first="Lawrence" last="Park">Lawrence Park</name><affiliation><nlm:aff id="A1">Department of Medicine, Duke University, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Tong, Steven Y C" sort="Tong, Steven Y C" uniqKey="Tong S" first="Steven Y. C." last="Tong">Steven Y. C. Tong</name><affiliation><nlm:aff id="A3">Charles Darwin University, Darwin, Northern Territory, Australia</nlm:aff></affiliation></author><author><name sortKey="Selton Suty, Christine" sort="Selton Suty, Christine" uniqKey="Selton Suty C" first="Christine" last="Selton-Suty">Christine Selton-Suty</name><affiliation><nlm:aff id="A4">Cardiology Service, CHU Nancy-Brabois, Nancy, France</nlm:aff></affiliation></author><author><name sortKey="Peterson, Gail" sort="Peterson, Gail" uniqKey="Peterson G" first="Gail" last="Peterson">Gail Peterson</name><affiliation><nlm:aff id="A5">Department of Medicine, UT-Southwestern Medical Center, Dallas, TX</nlm:aff></affiliation></author><author><name sortKey="Cecchi, Enrico" sort="Cecchi, Enrico" uniqKey="Cecchi E" first="Enrico" last="Cecchi">Enrico Cecchi</name><affiliation><nlm:aff id="A6">Department of Cardiology, Maria Vittoria Hospital, Torino, Italy</nlm:aff></affiliation></author><author><name sortKey="Afonso, Luis" sort="Afonso, Luis" uniqKey="Afonso L" first="Luis" last="Afonso">Luis Afonso</name><affiliation><nlm:aff id="A7">Department of Medicine, Wayne State University, Detroit, MI</nlm:aff></affiliation></author><author><name sortKey="Habib, Gilbert" sort="Habib, Gilbert" uniqKey="Habib G" first="Gilbert" last="Habib">Gilbert Habib</name><affiliation><nlm:aff id="A8">Faculté de Médecine de Marseille, Marseille, France</nlm:aff></affiliation></author><author><name sortKey="Pare, Carlos" sort="Pare, Carlos" uniqKey="Pare C" first="Carlos" last="Paré">Carlos Paré</name><affiliation><nlm:aff id="A9">Department of Cardiology, University of Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Tamin, Syahidah" sort="Tamin, Syahidah" uniqKey="Tamin S" first="Syahidah" last="Tamin">Syahidah Tamin</name><affiliation><nlm:aff id="A10">Department of Cardiology, Institut Jantung Negara, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Dickerman, Stuart" sort="Dickerman, Stuart" uniqKey="Dickerman S" first="Stuart" last="Dickerman">Stuart Dickerman</name><affiliation><nlm:aff id="A11">Department of Medicine, NYU, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Bayer, Arnold S" sort="Bayer, Arnold S" uniqKey="Bayer A" first="Arnold S." last="Bayer">Arnold S. Bayer</name><affiliation><nlm:aff id="A12">Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, UCLA, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Johansson, Magnus C" sort="Johansson, Magnus C" uniqKey="Johansson M" first="Magnus C." last="Johansson">Magnus C. Johansson</name><affiliation><nlm:aff id="A13">Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Chu, Vivian H" sort="Chu, Vivian H" uniqKey="Chu V" first="Vivian H." last="Chu">Vivian H. Chu</name><affiliation><nlm:aff id="A1">Department of Medicine, Duke University, Durham, NC</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Duke Clinical Research Institute, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Samad, Zainab" sort="Samad, Zainab" uniqKey="Samad Z" first="Zainab" last="Samad">Zainab Samad</name><affiliation><nlm:aff id="A1">Department of Medicine, Duke University, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Bruun, Niels E" sort="Bruun, Niels E" uniqKey="Bruun N" first="Niels E." last="Bruun">Niels E. Bruun</name><affiliation><nlm:aff id="A2">Department of Cardiology, Gentofte University, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Aalborg University, Aalborg, Denmark</nlm:aff></affiliation></author><author><name sortKey="Fowler, Vance G" sort="Fowler, Vance G" uniqKey="Fowler V" first="Vance G." last="Fowler">Vance G. Fowler</name><affiliation><nlm:aff id="A1">Department of Medicine, Duke University, Durham, NC</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Duke Clinical Research Institute, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Crowley, Anna Lisa" sort="Crowley, Anna Lisa" uniqKey="Crowley A" first="Anna Lisa" last="Crowley">Anna Lisa Crowley</name><affiliation><nlm:aff id="A1">Department of Medicine, Duke University, Durham, NC</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Duke Clinical Research Institute, Durham, NC</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26162783</idno><idno type="pmc">4503384</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503384</idno><idno type="RBID">PMC:4503384</idno><idno type="doi">10.1161/CIRCIMAGING.114.003397</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001E55</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E55</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Echocardiographic Findings Predict In-Hospital and One-Year Mortality in Left-Sided Native Valve <italic>Staphylococcus aureus</italic> Endocarditis: An Analysis from The International Collaboration on Endocarditis-Prospective Echo Cohort Study</title><author><name sortKey="Lauridsen, Trine K" sort="Lauridsen, Trine K" uniqKey="Lauridsen T" first="Trine K." last="Lauridsen">Trine K. Lauridsen</name><affiliation><nlm:aff id="A1">Department of Medicine, Duke University, Durham, NC</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Cardiology, Gentofte University, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Park, Lawrence" sort="Park, Lawrence" uniqKey="Park L" first="Lawrence" last="Park">Lawrence Park</name><affiliation><nlm:aff id="A1">Department of Medicine, Duke University, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Tong, Steven Y C" sort="Tong, Steven Y C" uniqKey="Tong S" first="Steven Y. C." last="Tong">Steven Y. C. Tong</name><affiliation><nlm:aff id="A3">Charles Darwin University, Darwin, Northern Territory, Australia</nlm:aff></affiliation></author><author><name sortKey="Selton Suty, Christine" sort="Selton Suty, Christine" uniqKey="Selton Suty C" first="Christine" last="Selton-Suty">Christine Selton-Suty</name><affiliation><nlm:aff id="A4">Cardiology Service, CHU Nancy-Brabois, Nancy, France</nlm:aff></affiliation></author><author><name sortKey="Peterson, Gail" sort="Peterson, Gail" uniqKey="Peterson G" first="Gail" last="Peterson">Gail Peterson</name><affiliation><nlm:aff id="A5">Department of Medicine, UT-Southwestern Medical Center, Dallas, TX</nlm:aff></affiliation></author><author><name sortKey="Cecchi, Enrico" sort="Cecchi, Enrico" uniqKey="Cecchi E" first="Enrico" last="Cecchi">Enrico Cecchi</name><affiliation><nlm:aff id="A6">Department of Cardiology, Maria Vittoria Hospital, Torino, Italy</nlm:aff></affiliation></author><author><name sortKey="Afonso, Luis" sort="Afonso, Luis" uniqKey="Afonso L" first="Luis" last="Afonso">Luis Afonso</name><affiliation><nlm:aff id="A7">Department of Medicine, Wayne State University, Detroit, MI</nlm:aff></affiliation></author><author><name sortKey="Habib, Gilbert" sort="Habib, Gilbert" uniqKey="Habib G" first="Gilbert" last="Habib">Gilbert Habib</name><affiliation><nlm:aff id="A8">Faculté de Médecine de Marseille, Marseille, France</nlm:aff></affiliation></author><author><name sortKey="Pare, Carlos" sort="Pare, Carlos" uniqKey="Pare C" first="Carlos" last="Paré">Carlos Paré</name><affiliation><nlm:aff id="A9">Department of Cardiology, University of Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Tamin, Syahidah" sort="Tamin, Syahidah" uniqKey="Tamin S" first="Syahidah" last="Tamin">Syahidah Tamin</name><affiliation><nlm:aff id="A10">Department of Cardiology, Institut Jantung Negara, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Dickerman, Stuart" sort="Dickerman, Stuart" uniqKey="Dickerman S" first="Stuart" last="Dickerman">Stuart Dickerman</name><affiliation><nlm:aff id="A11">Department of Medicine, NYU, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Bayer, Arnold S" sort="Bayer, Arnold S" uniqKey="Bayer A" first="Arnold S." last="Bayer">Arnold S. Bayer</name><affiliation><nlm:aff id="A12">Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, UCLA, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Johansson, Magnus C" sort="Johansson, Magnus C" uniqKey="Johansson M" first="Magnus C." last="Johansson">Magnus C. Johansson</name><affiliation><nlm:aff id="A13">Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden</nlm:aff></affiliation></author><author><name sortKey="Chu, Vivian H" sort="Chu, Vivian H" uniqKey="Chu V" first="Vivian H." last="Chu">Vivian H. Chu</name><affiliation><nlm:aff id="A1">Department of Medicine, Duke University, Durham, NC</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Duke Clinical Research Institute, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Samad, Zainab" sort="Samad, Zainab" uniqKey="Samad Z" first="Zainab" last="Samad">Zainab Samad</name><affiliation><nlm:aff id="A1">Department of Medicine, Duke University, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Bruun, Niels E" sort="Bruun, Niels E" uniqKey="Bruun N" first="Niels E." last="Bruun">Niels E. Bruun</name><affiliation><nlm:aff id="A2">Department of Cardiology, Gentofte University, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Aalborg University, Aalborg, Denmark</nlm:aff></affiliation></author><author><name sortKey="Fowler, Vance G" sort="Fowler, Vance G" uniqKey="Fowler V" first="Vance G." last="Fowler">Vance G. Fowler</name><affiliation><nlm:aff id="A1">Department of Medicine, Duke University, Durham, NC</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Duke Clinical Research Institute, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Crowley, Anna Lisa" sort="Crowley, Anna Lisa" uniqKey="Crowley A" first="Anna Lisa" last="Crowley">Anna Lisa Crowley</name><affiliation><nlm:aff id="A1">Department of Medicine, Duke University, Durham, NC</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Duke Clinical Research Institute, Durham, NC</nlm:aff></affiliation></author></analytic><series><title level="j">Circulation. Cardiovascular imaging</title><idno type="ISSN">1941-9651</idno><idno type="eISSN">1942-0080</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1"><italic>Staphylococcus (S.) aureus</italic> left-sided native valve infective endocarditis (LNVIE) has higher complication and mortality rates compared with endocarditis from other pathogens. Whether echocardiographic variables can predict prognosis in <italic>S. aureus</italic> LNVIE is unknown.</p></sec><sec id="S2"><title>Methods and Results</title><p id="P2">Consecutive patients with LNVIE, enrolled between January 2000 and September 2006, in the International Collaboration on Endocarditis were identified. Subjects without <italic>S. aureus</italic> IE were matched to those with <italic>S. aureus</italic> IE by the propensity of having <italic>S. aureus</italic>. Survival differences were determined using log-rank significance tests. Independent echocardiographic predictors of mortality were identified using Cox-proportional hazards models that included inverse probability of treatment weighting and surgery as a time-dependent covariate. Of 727 subjects with LNVIE and 1-year follow-up, 202 had <italic>S. aureus</italic> IE. One-year survival rates were significantly lower for patients with <italic>S. aureus</italic> IE overall (57% <italic>S. aureus</italic> IE vs. 80% non-<italic>S. aureus</italic> IE, p<0.001) and in the propensity-matched cohort (59% <italic>S. aureus</italic> IE vs. 68% non-<italic>S. aureus</italic> IE, p<0.05). Intracardiac abscess (HR 2.93; 95%CI 1.52–5.40, p<0.001) and left ventricular ejection fraction (LVEF)<40% (OR 3.01; 95%CI 1.35–6.04, p=0.004) were the only independent echocardiographic predictors of in-hospital mortality in <italic>S. aureus</italic> LNVIE. Valve perforation (HR 2.16; 95% CI 1.21–3.68, p=0.006) and intracardiac abscess (HR 2.25; 95%CI 1.26–3.78, p=0.004) were the only independent predictors of one-year mortality.</p></sec><sec id="S3"><title>Conclusions</title><p id="P3"><italic>S. aureus</italic> is an independent predictor of one-year mortality in subjects with LNVIE. In <italic>S. aureus</italic> LNVIE, intracardiac abscess and LVEF<40% independently predicted in-hospital mortality and intracardiac abscess and perforation independently predicted one-year mortality.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101479935</journal-id><journal-id journal-id-type="pubmed-jr-id">36052</journal-id><journal-id journal-id-type="nlm-ta">Circ Cardiovasc Imaging</journal-id><journal-id journal-id-type="iso-abbrev">Circ Cardiovasc Imaging</journal-id><journal-title-group><journal-title>Circulation. Cardiovascular imaging</journal-title></journal-title-group><issn pub-type="ppub">1941-9651</issn><issn pub-type="epub">1942-0080</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26162783</article-id><article-id pub-id-type="pmc">4503384</article-id><article-id pub-id-type="doi">10.1161/CIRCIMAGING.114.003397</article-id><article-id pub-id-type="manuscript">NIHMS702117</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Echocardiographic Findings Predict In-Hospital and One-Year Mortality in Left-Sided Native Valve <italic>Staphylococcus aureus</italic> Endocarditis: An Analysis from The International Collaboration on Endocarditis-Prospective Echo Cohort Study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lauridsen</surname><given-names>Trine K.</given-names></name><degrees> MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Lawrence</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tong</surname><given-names>Steven Y.C.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Selton-Suty</surname><given-names>Christine</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Peterson</surname><given-names>Gail</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Cecchi</surname><given-names>Enrico</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Afonso</surname><given-names>Luis</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Habib</surname><given-names>Gilbert</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Paré</surname><given-names>Carlos</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Tamin</surname><given-names>Syahidah</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Dickerman</surname><given-names>Stuart</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Bayer</surname><given-names>Arnold S.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Johansson</surname><given-names>Magnus C.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Chu</surname><given-names>Vivian H.</given-names></name><degrees>MD, MHS</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Samad</surname><given-names>Zainab</given-names></name><degrees>MD, MHS</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bruun</surname><given-names>Niels E.</given-names></name><degrees>MD, DMSc</degrees><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Fowler</surname><given-names>Vance G.</given-names><suffix>Jr</suffix></name><degrees>MD, MHS</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Crowley</surname><given-names>Anna Lisa</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A14">14</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Medicine, Duke University, Durham, NC</aff><aff id="A2"><label>2</label>Department of Cardiology, Gentofte University, Copenhagen, Denmark</aff><aff id="A3"><label>3</label>Charles Darwin University, Darwin, Northern Territory, Australia</aff><aff id="A4"><label>4</label>Cardiology Service, CHU Nancy-Brabois, Nancy, France</aff><aff id="A5"><label>5</label>Department of Medicine, UT-Southwestern Medical Center, Dallas, TX</aff><aff id="A6"><label>6</label>Department of Cardiology, Maria Vittoria Hospital, Torino, Italy</aff><aff id="A7"><label>7</label>Department of Medicine, Wayne State University, Detroit, MI</aff><aff id="A8"><label>8</label>Faculté de Médecine de Marseille, Marseille, France</aff><aff id="A9"><label>9</label>Department of Cardiology, University of Barcelona, Spain</aff><aff id="A10"><label>10</label>Department of Cardiology, Institut Jantung Negara, Kuala Lumpur, Malaysia</aff><aff id="A11"><label>11</label>Department of Medicine, NYU, New York, NY</aff><aff id="A12"><label>12</label>Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, UCLA, Los Angeles, CA</aff><aff id="A13"><label>13</label>Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden</aff><aff id="A14"><label>14</label>Duke Clinical Research Institute, Durham, NC</aff><aff id="A15"><label>15</label>Aalborg University, Aalborg, Denmark</aff><author-notes><corresp id="cor1"><bold>Correspondence to</bold>. Anna Lisa Crowley MD, Box 2805 DUMC, Durham NC 27705, Phone: (919) 668-2796, Fax: (919) 668-3575, <email>annalisa.crowley@duke.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>25</day><month>6</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>7</month><year>2016</year></pub-date><volume>8</volume><issue>7</issue><elocation-id>10.1161/CIRCIMAGING.114.003397 e003397</elocation-id><abstract><sec id="S1"><title>Background</title><p id="P1"><italic>Staphylococcus (S.) aureus</italic> left-sided native valve infective endocarditis (LNVIE) has higher complication and mortality rates compared with endocarditis from other pathogens. Whether echocardiographic variables can predict prognosis in <italic>S. aureus</italic> LNVIE is unknown.</p></sec><sec id="S2"><title>Methods and Results</title><p id="P2">Consecutive patients with LNVIE, enrolled between January 2000 and September 2006, in the International Collaboration on Endocarditis were identified. Subjects without <italic>S. aureus</italic> IE were matched to those with <italic>S. aureus</italic> IE by the propensity of having <italic>S. aureus</italic>. Survival differences were determined using log-rank significance tests. Independent echocardiographic predictors of mortality were identified using Cox-proportional hazards models that included inverse probability of treatment weighting and surgery as a time-dependent covariate. Of 727 subjects with LNVIE and 1-year follow-up, 202 had <italic>S. aureus</italic> IE. One-year survival rates were significantly lower for patients with <italic>S. aureus</italic> IE overall (57% <italic>S. aureus</italic> IE vs. 80% non-<italic>S. aureus</italic> IE, p<0.001) and in the propensity-matched cohort (59% <italic>S. aureus</italic> IE vs. 68% non-<italic>S. aureus</italic> IE, p<0.05). Intracardiac abscess (HR 2.93; 95%CI 1.52–5.40, p<0.001) and left ventricular ejection fraction (LVEF)<40% (OR 3.01; 95%CI 1.35–6.04, p=0.004) were the only independent echocardiographic predictors of in-hospital mortality in <italic>S. aureus</italic> LNVIE. Valve perforation (HR 2.16; 95% CI 1.21–3.68, p=0.006) and intracardiac abscess (HR 2.25; 95%CI 1.26–3.78, p=0.004) were the only independent predictors of one-year mortality.</p></sec><sec id="S3"><title>Conclusions</title><p id="P3"><italic>S. aureus</italic> is an independent predictor of one-year mortality in subjects with LNVIE. In <italic>S. aureus</italic> LNVIE, intracardiac abscess and LVEF<40% independently predicted in-hospital mortality and intracardiac abscess and perforation independently predicted one-year mortality.</p></sec></abstract><kwd-group><kwd>endocarditis</kwd><kwd>echocardiography</kwd><kwd>valve</kwd><kwd>risk factor</kwd><kwd>survival analysis</kwd><kwd>infective endocarditis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |