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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Unified Nomenclature and Amino Acid Numbering for Human PTEN</title><author><name sortKey="Pulido, Rafael" sort="Pulido, Rafael" uniqKey="Pulido R" first="Rafael" last="Pulido">Rafael Pulido</name><affiliation><nlm:aff id="A1">Ikerbasque, Basque Foundation for Science, Bilbao, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A2">BioCruces Health Research Institute, Barakaldo, Spain</nlm:aff></affiliation></author><author><name sortKey="Baker, Suzanne J" sort="Baker, Suzanne J" uniqKey="Baker S" first="Suzanne J." last="Baker">Suzanne J. Baker</name><affiliation><nlm:aff id="A3">Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, USA</nlm:aff></affiliation></author><author><name sortKey="Barata, Joao T" sort="Barata, Joao T" uniqKey="Barata J" first="Joao T." last="Barata">Joao T. Barata</name><affiliation><nlm:aff id="A4">Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal</nlm:aff></affiliation></author><author><name sortKey="Carracedo, Arkaitz" sort="Carracedo, Arkaitz" uniqKey="Carracedo A" first="Arkaitz" last="Carracedo">Arkaitz Carracedo</name><affiliation><nlm:aff id="A1">Ikerbasque, Basque Foundation for Science, Bilbao, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A5">CIC bioGUNE, Bizkaia Technology Park, Derio, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao, Spain</nlm:aff></affiliation></author><author><name sortKey="Cid, Victor J" sort="Cid, Victor J" uniqKey="Cid V" first="Victor J." last="Cid">Victor J. Cid</name><affiliation><nlm:aff id="A6">Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRY-CIS), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Chin Sang, Ian D" sort="Chin Sang, Ian D" uniqKey="Chin Sang I" first="Ian D." last="Chin-Sang">Ian D. Chin-Sang</name><affiliation><nlm:aff id="A7">Department of Biology, Queen’s University, Kingston, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Dave, Vrushank" sort="Dave, Vrushank" uniqKey="Dave V" first="Vrushank" last="Davé">Vrushank Davé</name><affiliation><nlm:aff id="A8">Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA</nlm:aff></affiliation></author><author><name sortKey="Den Hertog, Jeroen" sort="Den Hertog, Jeroen" uniqKey="Den Hertog J" first="Jeroen" last="Den Hertog">Jeroen Den Hertog</name><affiliation><nlm:aff id="A9">Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands, and Institute of Biology, Leiden, Leiden, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Devreotes, Peter" sort="Devreotes, Peter" uniqKey="Devreotes P" first="Peter" last="Devreotes">Peter Devreotes</name><affiliation><nlm:aff id="A10">Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA</nlm:aff></affiliation></author><author><name sortKey="Eickholt, Britta J" sort="Eickholt, Britta J" uniqKey="Eickholt B" first="Britta J." last="Eickholt">Britta J. Eickholt</name><affiliation><nlm:aff id="A11">Charité—Universitätsmedizin Berlin, Institute of Biochemistry and Cluster of Excellence NeuroCure, Berlin, German</nlm:aff></affiliation></author><author><name sortKey="Eng, Charis" sort="Eng, Charis" uniqKey="Eng C" first="Charis" last="Eng">Charis Eng</name><affiliation><nlm:aff id="A12">Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Genetics and Genome Sciences and CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA</nlm:aff></affiliation></author><author><name sortKey="Furnari, Frank B" sort="Furnari, Frank B" uniqKey="Furnari F" first="Frank B." last="Furnari">Frank B. Furnari</name><affiliation><nlm:aff id="A13">Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Georgescu, Maria Magdalena" sort="Georgescu, Maria Magdalena" uniqKey="Georgescu M" first="Maria-Magdalena" last="Georgescu">Maria-Magdalena Georgescu</name><affiliation><nlm:aff id="A14">The University of Texas South-western Medical Center, Dallas, TX 75235, USA</nlm:aff></affiliation></author><author><name sortKey="Gericke, Arne" sort="Gericke, Arne" uniqKey="Gericke A" first="Arne" last="Gericke">Arne Gericke</name><affiliation><nlm:aff id="A15">Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609, USA</nlm:aff></affiliation></author><author><name sortKey="Hopkins, Benjamin" sort="Hopkins, Benjamin" uniqKey="Hopkins B" first="Benjamin" last="Hopkins">Benjamin Hopkins</name><affiliation><nlm:aff id="A16">Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff></affiliation></author><author><name sortKey="Jiang, Xeujun" sort="Jiang, Xeujun" uniqKey="Jiang X" first="Xeujun" last="Jiang">Xeujun Jiang</name><affiliation><nlm:aff id="A17">Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</nlm:aff></affiliation></author><author><name sortKey="Lee, Seung Rock" sort="Lee, Seung Rock" uniqKey="Lee S" first="Seung-Rock" last="Lee">Seung-Rock Lee</name><affiliation><nlm:aff id="A18">Department of Biomedical Sciences, Center for Creative Biomedical Scientists, Department of Biochemistry, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Losche, Mathias" sort="Losche, Mathias" uniqKey="Losche M" first="Mathias" last="Lösche">Mathias Lösche</name><affiliation><nlm:aff id="A19">Physics Department and Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh. PA 15213, USA; Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA</nlm:aff></affiliation></author><author><name sortKey="Malaney, Prerna" sort="Malaney, Prerna" uniqKey="Malaney P" first="Prerna" last="Malaney">Prerna Malaney</name><affiliation><nlm:aff id="A8">Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA</nlm:aff></affiliation></author><author><name sortKey="Matias Guiu, Xavier" sort="Matias Guiu, Xavier" uniqKey="Matias Guiu X" first="Xavier" last="Matias-Guiu">Xavier Matias-Guiu</name><affiliation><nlm:aff id="A20">Department of Pathology and Molecular Genetics/Oncologic Pathology Group, Hospital Universitari Arnau de Vilanova, Lleida, Spain; Biomedical Research Institute of Lleida (IRBLleida), Universitat de Lleida, Lleida, Spain</nlm:aff></affiliation></author><author><name sortKey="Molina, Maria" sort="Molina, Maria" uniqKey="Molina M" first="María" last="Molina">María Molina</name><affiliation><nlm:aff id="A6">Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRY-CIS), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Pandolfi, Pier Paolo" sort="Pandolfi, Pier Paolo" uniqKey="Pandolfi P" first="Pier Paolo" last="Pandolfi">Pier Paolo Pandolfi</name><affiliation><nlm:aff id="A21">Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Parsons, Ramon" sort="Parsons, Ramon" uniqKey="Parsons R" first="Ramon" last="Parsons">Ramon Parsons</name><affiliation><nlm:aff id="A16">Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff></affiliation></author><author><name sortKey="Pinton, Paolo" sort="Pinton, Paolo" uniqKey="Pinton P" first="Paolo" last="Pinton">Paolo Pinton</name><affiliation><nlm:aff id="A22">Department of Morphology, Surgery and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy</nlm:aff></affiliation></author><author><name sortKey="Rivas, Carmen" sort="Rivas, Carmen" uniqKey="Rivas C" first="Carmen" last="Rivas">Carmen Rivas</name><affiliation><nlm:aff id="A23">Departamento de Biología Molecular y Celular, Centro Nacional de Biotecnología-CSIC, Madrid, Spain; Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, CIMUS, Universidade de Santiago de Compostela (USC), Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain</nlm:aff></affiliation></author><author><name sortKey="Rocha, Rafael M" sort="Rocha, Rafael M" uniqKey="Rocha R" first="Rafael M." last="Rocha">Rafael M. Rocha</name><affiliation><nlm:aff id="A24">Research Center, Antonio Prudente Foundation, Hospital A.C. Camargo; Department of Anatomic Pathology, Hospital A.C. Camargo, São Paulo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Manuel S" sort="Rodriguez, Manuel S" uniqKey="Rodriguez M" first="Manuel S." last="Rodríguez">Manuel S. Rodríguez</name><affiliation><nlm:aff id="A25">Ubiquitylation and Cancer Molecular Biology, Inbiomed, San Sebastián, Spain</nlm:aff></affiliation></author><author><name sortKey="Ross, Alonzo H" sort="Ross, Alonzo H" uniqKey="Ross A" first="Alonzo H." last="Ross">Alonzo H. Ross</name><affiliation><nlm:aff id="A26">Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA</nlm:aff></affiliation></author><author><name sortKey="Serrano, Manuel" sort="Serrano, Manuel" uniqKey="Serrano M" first="Manuel" last="Serrano">Manuel Serrano</name><affiliation><nlm:aff id="A27">Spanish National Cancer Research Center (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Stambolic, Vuk" sort="Stambolic, Vuk" uniqKey="Stambolic V" first="Vuk" last="Stambolic">Vuk Stambolic</name><affiliation><nlm:aff id="A28">Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Stiles, Bangyan" sort="Stiles, Bangyan" uniqKey="Stiles B" first="Bangyan" last="Stiles">Bangyan Stiles</name><affiliation><nlm:aff id="A29">Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Suzuki, Akira" sort="Suzuki, Akira" uniqKey="Suzuki A" first="Akira" last="Suzuki">Akira Suzuki</name><affiliation><nlm:aff id="A30">Global Centers of Excellence Program, Akita University Graduate School of Medicine, Akita, Japan</nlm:aff></affiliation></author><author><name sortKey="Tan, Seong Seng" sort="Tan, Seong Seng" uniqKey="Tan S" first="Seong-Seng" last="Tan">Seong-Seng Tan</name><affiliation><nlm:aff id="A31">Brain Development and Regeneration Division, Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Tonks, Nicholas K" sort="Tonks, Nicholas K" uniqKey="Tonks N" first="Nicholas K." last="Tonks">Nicholas K. Tonks</name><affiliation><nlm:aff id="A32">Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA</nlm:aff></affiliation></author><author><name sortKey="Trotman, Lloyd C" sort="Trotman, Lloyd C" uniqKey="Trotman L" first="Lloyd C." last="Trotman">Lloyd C. Trotman</name><affiliation><nlm:aff id="A32">Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA</nlm:aff></affiliation></author><author><name sortKey="Wolff, Nicolas" sort="Wolff, Nicolas" uniqKey="Wolff N" first="Nicolas" last="Wolff">Nicolas Wolff</name><affiliation><nlm:aff id="A33">Institut Pasteur, Unité de Résonance Magnétique Nucléaire des Biomolécules, Département de Biologie Structurale et Chimie, CNRS, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Woscholski, Rudiger" sort="Woscholski, Rudiger" uniqKey="Woscholski R" first="Rudiger" last="Woscholski">Rudiger Woscholski</name><affiliation><nlm:aff id="A34">Department of Chemistry and Institute of Chemical Biology, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Wu, Hong" sort="Wu, Hong" uniqKey="Wu H" first="Hong" last="Wu">Hong Wu</name><affiliation><nlm:aff id="A35">Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA; School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Leslie, Nicholas R" sort="Leslie, Nicholas R" uniqKey="Leslie N" first="Nicholas R." last="Leslie">Nicholas R. Leslie</name><affiliation><nlm:aff id="A36">Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24985344</idno><idno type="pmc">4367864</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367864</idno><idno type="RBID">PMC:4367864</idno><idno type="doi">10.1126/scisignal.2005560</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001E52</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Unified Nomenclature and Amino Acid Numbering for Human PTEN</title><author><name sortKey="Pulido, Rafael" sort="Pulido, Rafael" uniqKey="Pulido R" first="Rafael" last="Pulido">Rafael Pulido</name><affiliation><nlm:aff id="A1">Ikerbasque, Basque Foundation for Science, Bilbao, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A2">BioCruces Health Research Institute, Barakaldo, Spain</nlm:aff></affiliation></author><author><name sortKey="Baker, Suzanne J" sort="Baker, Suzanne J" uniqKey="Baker S" first="Suzanne J." last="Baker">Suzanne J. Baker</name><affiliation><nlm:aff id="A3">Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, USA</nlm:aff></affiliation></author><author><name sortKey="Barata, Joao T" sort="Barata, Joao T" uniqKey="Barata J" first="Joao T." last="Barata">Joao T. Barata</name><affiliation><nlm:aff id="A4">Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal</nlm:aff></affiliation></author><author><name sortKey="Carracedo, Arkaitz" sort="Carracedo, Arkaitz" uniqKey="Carracedo A" first="Arkaitz" last="Carracedo">Arkaitz Carracedo</name><affiliation><nlm:aff id="A1">Ikerbasque, Basque Foundation for Science, Bilbao, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A5">CIC bioGUNE, Bizkaia Technology Park, Derio, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao, Spain</nlm:aff></affiliation></author><author><name sortKey="Cid, Victor J" sort="Cid, Victor J" uniqKey="Cid V" first="Victor J." last="Cid">Victor J. Cid</name><affiliation><nlm:aff id="A6">Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRY-CIS), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Chin Sang, Ian D" sort="Chin Sang, Ian D" uniqKey="Chin Sang I" first="Ian D." last="Chin-Sang">Ian D. Chin-Sang</name><affiliation><nlm:aff id="A7">Department of Biology, Queen’s University, Kingston, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Dave, Vrushank" sort="Dave, Vrushank" uniqKey="Dave V" first="Vrushank" last="Davé">Vrushank Davé</name><affiliation><nlm:aff id="A8">Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA</nlm:aff></affiliation></author><author><name sortKey="Den Hertog, Jeroen" sort="Den Hertog, Jeroen" uniqKey="Den Hertog J" first="Jeroen" last="Den Hertog">Jeroen Den Hertog</name><affiliation><nlm:aff id="A9">Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands, and Institute of Biology, Leiden, Leiden, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Devreotes, Peter" sort="Devreotes, Peter" uniqKey="Devreotes P" first="Peter" last="Devreotes">Peter Devreotes</name><affiliation><nlm:aff id="A10">Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA</nlm:aff></affiliation></author><author><name sortKey="Eickholt, Britta J" sort="Eickholt, Britta J" uniqKey="Eickholt B" first="Britta J." last="Eickholt">Britta J. Eickholt</name><affiliation><nlm:aff id="A11">Charité—Universitätsmedizin Berlin, Institute of Biochemistry and Cluster of Excellence NeuroCure, Berlin, German</nlm:aff></affiliation></author><author><name sortKey="Eng, Charis" sort="Eng, Charis" uniqKey="Eng C" first="Charis" last="Eng">Charis Eng</name><affiliation><nlm:aff id="A12">Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Genetics and Genome Sciences and CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA</nlm:aff></affiliation></author><author><name sortKey="Furnari, Frank B" sort="Furnari, Frank B" uniqKey="Furnari F" first="Frank B." last="Furnari">Frank B. Furnari</name><affiliation><nlm:aff id="A13">Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Georgescu, Maria Magdalena" sort="Georgescu, Maria Magdalena" uniqKey="Georgescu M" first="Maria-Magdalena" last="Georgescu">Maria-Magdalena Georgescu</name><affiliation><nlm:aff id="A14">The University of Texas South-western Medical Center, Dallas, TX 75235, USA</nlm:aff></affiliation></author><author><name sortKey="Gericke, Arne" sort="Gericke, Arne" uniqKey="Gericke A" first="Arne" last="Gericke">Arne Gericke</name><affiliation><nlm:aff id="A15">Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609, USA</nlm:aff></affiliation></author><author><name sortKey="Hopkins, Benjamin" sort="Hopkins, Benjamin" uniqKey="Hopkins B" first="Benjamin" last="Hopkins">Benjamin Hopkins</name><affiliation><nlm:aff id="A16">Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff></affiliation></author><author><name sortKey="Jiang, Xeujun" sort="Jiang, Xeujun" uniqKey="Jiang X" first="Xeujun" last="Jiang">Xeujun Jiang</name><affiliation><nlm:aff id="A17">Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</nlm:aff></affiliation></author><author><name sortKey="Lee, Seung Rock" sort="Lee, Seung Rock" uniqKey="Lee S" first="Seung-Rock" last="Lee">Seung-Rock Lee</name><affiliation><nlm:aff id="A18">Department of Biomedical Sciences, Center for Creative Biomedical Scientists, Department of Biochemistry, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Losche, Mathias" sort="Losche, Mathias" uniqKey="Losche M" first="Mathias" last="Lösche">Mathias Lösche</name><affiliation><nlm:aff id="A19">Physics Department and Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh. PA 15213, USA; Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA</nlm:aff></affiliation></author><author><name sortKey="Malaney, Prerna" sort="Malaney, Prerna" uniqKey="Malaney P" first="Prerna" last="Malaney">Prerna Malaney</name><affiliation><nlm:aff id="A8">Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA</nlm:aff></affiliation></author><author><name sortKey="Matias Guiu, Xavier" sort="Matias Guiu, Xavier" uniqKey="Matias Guiu X" first="Xavier" last="Matias-Guiu">Xavier Matias-Guiu</name><affiliation><nlm:aff id="A20">Department of Pathology and Molecular Genetics/Oncologic Pathology Group, Hospital Universitari Arnau de Vilanova, Lleida, Spain; Biomedical Research Institute of Lleida (IRBLleida), Universitat de Lleida, Lleida, Spain</nlm:aff></affiliation></author><author><name sortKey="Molina, Maria" sort="Molina, Maria" uniqKey="Molina M" first="María" last="Molina">María Molina</name><affiliation><nlm:aff id="A6">Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRY-CIS), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Pandolfi, Pier Paolo" sort="Pandolfi, Pier Paolo" uniqKey="Pandolfi P" first="Pier Paolo" last="Pandolfi">Pier Paolo Pandolfi</name><affiliation><nlm:aff id="A21">Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Harvard Medical School, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Parsons, Ramon" sort="Parsons, Ramon" uniqKey="Parsons R" first="Ramon" last="Parsons">Ramon Parsons</name><affiliation><nlm:aff id="A16">Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff></affiliation></author><author><name sortKey="Pinton, Paolo" sort="Pinton, Paolo" uniqKey="Pinton P" first="Paolo" last="Pinton">Paolo Pinton</name><affiliation><nlm:aff id="A22">Department of Morphology, Surgery and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy</nlm:aff></affiliation></author><author><name sortKey="Rivas, Carmen" sort="Rivas, Carmen" uniqKey="Rivas C" first="Carmen" last="Rivas">Carmen Rivas</name><affiliation><nlm:aff id="A23">Departamento de Biología Molecular y Celular, Centro Nacional de Biotecnología-CSIC, Madrid, Spain; Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, CIMUS, Universidade de Santiago de Compostela (USC), Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain</nlm:aff></affiliation></author><author><name sortKey="Rocha, Rafael M" sort="Rocha, Rafael M" uniqKey="Rocha R" first="Rafael M." last="Rocha">Rafael M. Rocha</name><affiliation><nlm:aff id="A24">Research Center, Antonio Prudente Foundation, Hospital A.C. Camargo; Department of Anatomic Pathology, Hospital A.C. Camargo, São Paulo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Manuel S" sort="Rodriguez, Manuel S" uniqKey="Rodriguez M" first="Manuel S." last="Rodríguez">Manuel S. Rodríguez</name><affiliation><nlm:aff id="A25">Ubiquitylation and Cancer Molecular Biology, Inbiomed, San Sebastián, Spain</nlm:aff></affiliation></author><author><name sortKey="Ross, Alonzo H" sort="Ross, Alonzo H" uniqKey="Ross A" first="Alonzo H." last="Ross">Alonzo H. Ross</name><affiliation><nlm:aff id="A26">Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA</nlm:aff></affiliation></author><author><name sortKey="Serrano, Manuel" sort="Serrano, Manuel" uniqKey="Serrano M" first="Manuel" last="Serrano">Manuel Serrano</name><affiliation><nlm:aff id="A27">Spanish National Cancer Research Center (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Stambolic, Vuk" sort="Stambolic, Vuk" uniqKey="Stambolic V" first="Vuk" last="Stambolic">Vuk Stambolic</name><affiliation><nlm:aff id="A28">Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Stiles, Bangyan" sort="Stiles, Bangyan" uniqKey="Stiles B" first="Bangyan" last="Stiles">Bangyan Stiles</name><affiliation><nlm:aff id="A29">Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA</nlm:aff></affiliation></author><author><name sortKey="Suzuki, Akira" sort="Suzuki, Akira" uniqKey="Suzuki A" first="Akira" last="Suzuki">Akira Suzuki</name><affiliation><nlm:aff id="A30">Global Centers of Excellence Program, Akita University Graduate School of Medicine, Akita, Japan</nlm:aff></affiliation></author><author><name sortKey="Tan, Seong Seng" sort="Tan, Seong Seng" uniqKey="Tan S" first="Seong-Seng" last="Tan">Seong-Seng Tan</name><affiliation><nlm:aff id="A31">Brain Development and Regeneration Division, Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Tonks, Nicholas K" sort="Tonks, Nicholas K" uniqKey="Tonks N" first="Nicholas K." last="Tonks">Nicholas K. Tonks</name><affiliation><nlm:aff id="A32">Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA</nlm:aff></affiliation></author><author><name sortKey="Trotman, Lloyd C" sort="Trotman, Lloyd C" uniqKey="Trotman L" first="Lloyd C." last="Trotman">Lloyd C. Trotman</name><affiliation><nlm:aff id="A32">Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA</nlm:aff></affiliation></author><author><name sortKey="Wolff, Nicolas" sort="Wolff, Nicolas" uniqKey="Wolff N" first="Nicolas" last="Wolff">Nicolas Wolff</name><affiliation><nlm:aff id="A33">Institut Pasteur, Unité de Résonance Magnétique Nucléaire des Biomolécules, Département de Biologie Structurale et Chimie, CNRS, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Woscholski, Rudiger" sort="Woscholski, Rudiger" uniqKey="Woscholski R" first="Rudiger" last="Woscholski">Rudiger Woscholski</name><affiliation><nlm:aff id="A34">Department of Chemistry and Institute of Chemical Biology, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Wu, Hong" sort="Wu, Hong" uniqKey="Wu H" first="Hong" last="Wu">Hong Wu</name><affiliation><nlm:aff id="A35">Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA; School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Leslie, Nicholas R" sort="Leslie, Nicholas R" uniqKey="Leslie N" first="Nicholas R." last="Leslie">Nicholas R. Leslie</name><affiliation><nlm:aff id="A36">Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Science signaling</title><idno type="eISSN">1937-9145</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P<sub>3</sub>] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101465400</journal-id><journal-id journal-id-type="pubmed-jr-id">34171</journal-id><journal-id journal-id-type="nlm-ta">Sci Signal</journal-id><journal-id journal-id-type="iso-abbrev">Sci Signal</journal-id><journal-title-group><journal-title>Science signaling</journal-title></journal-title-group><issn pub-type="epub">1937-9145</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24985344</article-id><article-id pub-id-type="pmc">4367864</article-id><article-id pub-id-type="doi">10.1126/scisignal.2005560</article-id><article-id pub-id-type="manuscript">NIHMS671399</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A Unified Nomenclature and Amino Acid Numbering for Human PTEN</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Pulido</surname><given-names>Rafael</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Baker</surname><given-names>Suzanne J.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Barata</surname><given-names>Joao T.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Carracedo</surname><given-names>Arkaitz</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Cid</surname><given-names>Victor J.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Chin-Sang</surname><given-names>Ian D.</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Davé</surname><given-names>Vrushank</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>den Hertog</surname><given-names>Jeroen</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Devreotes</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Eickholt</surname><given-names>Britta J.</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Eng</surname><given-names>Charis</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Furnari</surname><given-names>Frank B.</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Georgescu</surname><given-names>Maria-Magdalena</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Gericke</surname><given-names>Arne</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Hopkins</surname><given-names>Benjamin</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Jiang</surname><given-names>Xeujun</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Seung-Rock</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Lösche</surname><given-names>Mathias</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Malaney</surname><given-names>Prerna</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Matias-Guiu</surname><given-names>Xavier</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Molina</surname><given-names>María</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Pandolfi</surname><given-names>Pier Paolo</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Parsons</surname><given-names>Ramon</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Pinton</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Rivas</surname><given-names>Carmen</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Rocha</surname><given-names>Rafael M.</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Rodríguez</surname><given-names>Manuel S.</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Ross</surname><given-names>Alonzo H.</given-names></name><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Serrano</surname><given-names>Manuel</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Stambolic</surname><given-names>Vuk</given-names></name><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Stiles</surname><given-names>Bangyan</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Suzuki</surname><given-names>Akira</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Seong-Seng</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Tonks</surname><given-names>Nicholas K.</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Trotman</surname><given-names>Lloyd C.</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Wolff</surname><given-names>Nicolas</given-names></name><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Woscholski</surname><given-names>Rudiger</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Hong</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Leslie</surname><given-names>Nicholas R.</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib></contrib-group><aff id="A1"><label>1</label>Ikerbasque, Basque Foundation for Science, Bilbao, Spain</aff><aff id="A2"><label>2</label>BioCruces Health Research Institute, Barakaldo, Spain</aff><aff id="A3"><label>3</label>Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, USA</aff><aff id="A4"><label>4</label>Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal</aff><aff id="A5"><label>5</label>CIC bioGUNE, Bizkaia Technology Park, Derio, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao, Spain</aff><aff id="A6"><label>6</label>Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRY-CIS), Madrid, Spain</aff><aff id="A7"><label>7</label>Department of Biology, Queen’s University, Kingston, Ontario, Canada</aff><aff id="A8"><label>8</label>Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA</aff><aff id="A9"><label>9</label>Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands, and Institute of Biology, Leiden, Leiden, Netherlands</aff><aff id="A10"><label>10</label>Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA</aff><aff id="A11"><label>11</label>Charité—Universitätsmedizin Berlin, Institute of Biochemistry and Cluster of Excellence NeuroCure, Berlin, German</aff><aff id="A12"><label>12</label>Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Genetics and Genome Sciences and CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA</aff><aff id="A13"><label>13</label>Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA</aff><aff id="A14"><label>14</label>The University of Texas South-western Medical Center, Dallas, TX 75235, USA</aff><aff id="A15"><label>15</label>Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609, USA</aff><aff id="A16"><label>16</label>Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</aff><aff id="A17"><label>17</label>Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</aff><aff id="A18"><label>18</label>Department of Biomedical Sciences, Center for Creative Biomedical Scientists, Department of Biochemistry, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, Republic of Korea</aff><aff id="A19"><label>19</label>Physics Department and Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh. PA 15213, USA; Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA</aff><aff id="A20"><label>20</label>Department of Pathology and Molecular Genetics/Oncologic Pathology Group, Hospital Universitari Arnau de Vilanova, Lleida, Spain; Biomedical Research Institute of Lleida (IRBLleida), Universitat de Lleida, Lleida, Spain</aff><aff id="A21"><label>21</label>Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Harvard Medical School, Boston, MA 02115, USA</aff><aff id="A22"><label>22</label>Department of Morphology, Surgery and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy</aff><aff id="A23"><label>23</label>Departamento de Biología Molecular y Celular, Centro Nacional de Biotecnología-CSIC, Madrid, Spain; Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, CIMUS, Universidade de Santiago de Compostela (USC), Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain</aff><aff id="A24"><label>24</label>Research Center, Antonio Prudente Foundation, Hospital A.C. Camargo; Department of Anatomic Pathology, Hospital A.C. Camargo, São Paulo, Brazil</aff><aff id="A25"><label>25</label>Ubiquitylation and Cancer Molecular Biology, Inbiomed, San Sebastián, Spain</aff><aff id="A26"><label>26</label>Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA</aff><aff id="A27"><label>27</label>Spanish National Cancer Research Center (CNIO), Madrid, Spain</aff><aff id="A28"><label>28</label>Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada</aff><aff id="A29"><label>29</label>Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA</aff><aff id="A30"><label>30</label>Global Centers of Excellence Program, Akita University Graduate School of Medicine, Akita, Japan</aff><aff id="A31"><label>31</label>Brain Development and Regeneration Division, Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria, Australia</aff><aff id="A32"><label>32</label>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA</aff><aff id="A33"><label>33</label>Institut Pasteur, Unité de Résonance Magnétique Nucléaire des Biomolécules, Département de Biologie Structurale et Chimie, CNRS, Paris, France</aff><aff id="A34"><label>34</label>Department of Chemistry and Institute of Chemical Biology, Imperial College London, London, UK</aff><aff id="A35"><label>35</label>Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA; School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China</aff><aff id="A36"><label>36</label>Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh, UK</aff><author-notes><corresp id="cor1"><label>*</label>Corresponding author. <email>rpulidomurillo@gmail.com</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>01</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="collection"><day>1</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>20</day><month>3</month><year>2015</year></pub-date><volume>7</volume><issue>332</issue><fpage>pe15</fpage><lpage>pe15</lpage><pmc-comment>elocation-id from pubmed: 10.1126/scisignal.2005560</pmc-comment>
<permissions><copyright-statement>Copyright 2014 by the American Association for the Advancement of Science; all rights reserved.</copyright-statement><copyright-year>2014</copyright-year><license license-type="permissions-link"><license-p><bold>Permissions</bold> Obtain information about reproducing this article: <ext-link ext-link-type="uri" xlink:href="http://www.sciencemag.org/about/permissions.dtl">http://www.sciencemag.org/about/permissions.dtl</ext-link></license-p></license></permissions><abstract><p id="P1">The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P<sub>3</sub>] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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