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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The CSF-1 receptor fashions the intestinal stem cell niche<sup><xref ref-type="fn" rid="FN1">✩</xref></sup></title><author><name sortKey="Akcora, Dilara" sort="Akcora, Dilara" uniqKey="Akcora D" first="Dilara" last="Akcora">Dilara Akcora</name><affiliation><nlm:aff id="A1">Peter MacCallum Cancer Centre and the Sir Peter MacCallum Oncology Department and the Pathology Department, University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Huynh, Duy" sort="Huynh, Duy" uniqKey="Huynh D" first="Duy" last="Huynh">Duy Huynh</name><affiliation><nlm:aff id="A1">Peter MacCallum Cancer Centre and the Sir Peter MacCallum Oncology Department and the Pathology Department, University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Lightowler, Sally" sort="Lightowler, Sally" uniqKey="Lightowler S" first="Sally" last="Lightowler">Sally Lightowler</name><affiliation><nlm:aff id="A1">Peter MacCallum Cancer Centre and the Sir Peter MacCallum Oncology Department and the Pathology Department, University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Germann, Markus" sort="Germann, Markus" uniqKey="Germann M" first="Markus" last="Germann">Markus Germann</name><affiliation><nlm:aff id="A1">Peter MacCallum Cancer Centre and the Sir Peter MacCallum Oncology Department and the Pathology Department, University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Robine, Sylvie" sort="Robine, Sylvie" uniqKey="Robine S" first="Sylvie" last="Robine">Sylvie Robine</name><affiliation><nlm:aff id="A2">Centre National de la Recherche Scientifique, Institut Curie, 75248 Paris, Cedex 05, France</nlm:aff></affiliation></author><author><name sortKey="De May, Jan R" sort="De May, Jan R" uniqKey="De May J" first="Jan R." last="De May">Jan R. De May</name><affiliation><nlm:aff id="A3">CNRS, UMR 7213, Laboratoire de Biophotonique et Pharmacologie, F-67401 Illkirch, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Université de Strasbourg, F-67081, France</nlm:aff></affiliation></author><author><name sortKey="Pollard, Jeffrey W" sort="Pollard, Jeffrey W" uniqKey="Pollard J" first="Jeffrey W." last="Pollard">Jeffrey W. Pollard</name><affiliation><nlm:aff id="A5">Albert Einstein College of Medicine, Bronx, NY 10461, USA</nlm:aff></affiliation></author><author><name sortKey="Stanley, E Richard" sort="Stanley, E Richard" uniqKey="Stanley E" first="E. Richard" last="Stanley">E. Richard Stanley</name><affiliation><nlm:aff id="A5">Albert Einstein College of Medicine, Bronx, NY 10461, USA</nlm:aff></affiliation></author><author><name sortKey="Malaterre, Jordane" sort="Malaterre, Jordane" uniqKey="Malaterre J" first="Jordane" last="Malaterre">Jordane Malaterre</name><affiliation><nlm:aff id="A1">Peter MacCallum Cancer Centre and the Sir Peter MacCallum Oncology Department and the Pathology Department, University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Ramsay, Robert G" sort="Ramsay, Robert G" uniqKey="Ramsay R" first="Robert G." last="Ramsay">Robert G. Ramsay</name><affiliation><nlm:aff id="A1">Peter MacCallum Cancer Centre and the Sir Peter MacCallum Oncology Department and the Pathology Department, University of Melbourne, Australia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23314290</idno><idno type="pmc">4096353</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096353</idno><idno type="RBID">PMC:4096353</idno><idno type="doi">10.1016/j.scr.2012.12.001</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001E49</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E49</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The CSF-1 receptor fashions the intestinal stem cell niche<sup><xref ref-type="fn" rid="FN1">✩</xref></sup></title><author><name sortKey="Akcora, Dilara" sort="Akcora, Dilara" uniqKey="Akcora D" first="Dilara" last="Akcora">Dilara Akcora</name><affiliation><nlm:aff id="A1">Peter MacCallum Cancer Centre and the Sir Peter MacCallum Oncology Department and the Pathology Department, University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Huynh, Duy" sort="Huynh, Duy" uniqKey="Huynh D" first="Duy" last="Huynh">Duy Huynh</name><affiliation><nlm:aff id="A1">Peter MacCallum Cancer Centre and the Sir Peter MacCallum Oncology Department and the Pathology Department, University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Lightowler, Sally" sort="Lightowler, Sally" uniqKey="Lightowler S" first="Sally" last="Lightowler">Sally Lightowler</name><affiliation><nlm:aff id="A1">Peter MacCallum Cancer Centre and the Sir Peter MacCallum Oncology Department and the Pathology Department, University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Germann, Markus" sort="Germann, Markus" uniqKey="Germann M" first="Markus" last="Germann">Markus Germann</name><affiliation><nlm:aff id="A1">Peter MacCallum Cancer Centre and the Sir Peter MacCallum Oncology Department and the Pathology Department, University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Robine, Sylvie" sort="Robine, Sylvie" uniqKey="Robine S" first="Sylvie" last="Robine">Sylvie Robine</name><affiliation><nlm:aff id="A2">Centre National de la Recherche Scientifique, Institut Curie, 75248 Paris, Cedex 05, France</nlm:aff></affiliation></author><author><name sortKey="De May, Jan R" sort="De May, Jan R" uniqKey="De May J" first="Jan R." last="De May">Jan R. De May</name><affiliation><nlm:aff id="A3">CNRS, UMR 7213, Laboratoire de Biophotonique et Pharmacologie, F-67401 Illkirch, France</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Université de Strasbourg, F-67081, France</nlm:aff></affiliation></author><author><name sortKey="Pollard, Jeffrey W" sort="Pollard, Jeffrey W" uniqKey="Pollard J" first="Jeffrey W." last="Pollard">Jeffrey W. Pollard</name><affiliation><nlm:aff id="A5">Albert Einstein College of Medicine, Bronx, NY 10461, USA</nlm:aff></affiliation></author><author><name sortKey="Stanley, E Richard" sort="Stanley, E Richard" uniqKey="Stanley E" first="E. Richard" last="Stanley">E. Richard Stanley</name><affiliation><nlm:aff id="A5">Albert Einstein College of Medicine, Bronx, NY 10461, USA</nlm:aff></affiliation></author><author><name sortKey="Malaterre, Jordane" sort="Malaterre, Jordane" uniqKey="Malaterre J" first="Jordane" last="Malaterre">Jordane Malaterre</name><affiliation><nlm:aff id="A1">Peter MacCallum Cancer Centre and the Sir Peter MacCallum Oncology Department and the Pathology Department, University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Ramsay, Robert G" sort="Ramsay, Robert G" uniqKey="Ramsay R" first="Robert G." last="Ramsay">Robert G. Ramsay</name><affiliation><nlm:aff id="A1">Peter MacCallum Cancer Centre and the Sir Peter MacCallum Oncology Department and the Pathology Department, University of Melbourne, Australia</nlm:aff></affiliation></author></analytic><series><title level="j">Stem cell research</title><idno type="ISSN">1873-5061</idno><idno type="eISSN">1876-7753</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Gastrointestinal (GI) homeostasis requires the action of multiple pathways. There is some controversy regarding whether small intestine (SI) Paneth cells (PCs) play a central role in orchestrating crypt architecture and their relationship with Lgr5+ve stem cells. Nevertheless, we previously showed that germline CSF-1 receptor (<italic>Csf1r</italic>) knock out (KO) or <italic>Csf1</italic> mutation is associated with an absence of mature PC, reduced crypt proliferation and lowered stem cell gene, <italic>Lgr5</italic> expression. Here we show the additional loss of CD24, <italic>Bmi1</italic> and <italic>Olfm4</italic> expression in the KO crypts and a high resolution 3D localization of CSF-1R mainly to PC. The induction of GI-specific <italic>Csf1r</italic> deletion in young adult mice also led to PC loss over a period of weeks, in accord with the anticipated long life span of PC, changed distribution of proliferating cells and this was with a commensurate loss of <italic>Lgr5</italic> and other stem cell marker gene expression. By culturing SI organoids, we further show that the <italic>Csf1r</italic><sup>−/−</sup> defect in PC production is intrinsic to epithelial cells as well as definitively affecting stem cell activity. These results show that CSF-1R directly supports PC maturation and that in turn PCs fashion the intestinal stem cell niche.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101316957</journal-id><journal-id journal-id-type="pubmed-jr-id">35616</journal-id><journal-id journal-id-type="nlm-ta">Stem Cell Res</journal-id><journal-id journal-id-type="iso-abbrev">Stem Cell Res</journal-id><journal-title-group><journal-title>Stem cell research</journal-title></journal-title-group><issn pub-type="ppub">1873-5061</issn><issn pub-type="epub">1876-7753</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23314290</article-id><article-id pub-id-type="pmc">4096353</article-id><article-id pub-id-type="doi">10.1016/j.scr.2012.12.001</article-id><article-id pub-id-type="manuscript">NIHMS580161</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The CSF-1 receptor fashions the intestinal stem cell niche<sup><xref ref-type="fn" rid="FN1">✩</xref></sup></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Akcora</surname><given-names>Dilara</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Huynh</surname><given-names>Duy</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Lightowler</surname><given-names>Sally</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Germann</surname><given-names>Markus</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Robine</surname><given-names>Sylvie</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>de May</surname><given-names>Jan R.</given-names></name><xref ref-type="aff" rid="A3">c</xref><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Pollard</surname><given-names>Jeffrey W.</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Stanley</surname><given-names>E. Richard</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Malaterre</surname><given-names>Jordane</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Ramsay</surname><given-names>Robert G.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="A1"><label>a</label>Peter MacCallum Cancer Centre and the Sir Peter MacCallum Oncology Department and the Pathology Department, University of Melbourne, Australia</aff><aff id="A2"><label>b</label>Centre National de la Recherche Scientifique, Institut Curie, 75248 Paris, Cedex 05, France</aff><aff id="A3"><label>c</label>CNRS, UMR 7213, Laboratoire de Biophotonique et Pharmacologie, F-67401 Illkirch, France</aff><aff id="A4"><label>d</label>Université de Strasbourg, F-67081, France</aff><aff id="A5"><label>e</label>Albert Einstein College of Medicine, Bronx, NY 10461, USA</aff><author-notes><corresp id="cor1"><label>*</label>Corresponding author at: Differentiation and Transcription laboratory, Peter MacCallum Cancer Centre, East Melbourne, 3002 Victoria, Australia. Fax: +61 3 965 1411. <email>rob.ramsay@petermac.org</email> (R.G. Ramsay)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>12</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>09</day><month>12</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>3</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>14</day><month>7</month><year>2014</year></pub-date><volume>10</volume><issue>2</issue><fpage>203</fpage><lpage>212</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.scr.2012.12.001</pmc-comment>
<permissions><copyright-statement>© 2012 Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><p id="P1">Gastrointestinal (GI) homeostasis requires the action of multiple pathways. There is some controversy regarding whether small intestine (SI) Paneth cells (PCs) play a central role in orchestrating crypt architecture and their relationship with Lgr5+ve stem cells. Nevertheless, we previously showed that germline CSF-1 receptor (<italic>Csf1r</italic>) knock out (KO) or <italic>Csf1</italic> mutation is associated with an absence of mature PC, reduced crypt proliferation and lowered stem cell gene, <italic>Lgr5</italic> expression. Here we show the additional loss of CD24, <italic>Bmi1</italic> and <italic>Olfm4</italic> expression in the KO crypts and a high resolution 3D localization of CSF-1R mainly to PC. The induction of GI-specific <italic>Csf1r</italic> deletion in young adult mice also led to PC loss over a period of weeks, in accord with the anticipated long life span of PC, changed distribution of proliferating cells and this was with a commensurate loss of <italic>Lgr5</italic> and other stem cell marker gene expression. By culturing SI organoids, we further show that the <italic>Csf1r</italic><sup>−/−</sup> defect in PC production is intrinsic to epithelial cells as well as definitively affecting stem cell activity. These results show that CSF-1R directly supports PC maturation and that in turn PCs fashion the intestinal stem cell niche.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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