Staphylococcus aureus targets the Duffy antigen receptor for chemokines (DARC) to lyse erythrocytes
Identifieur interne : 001E48 ( Pmc/Corpus ); précédent : 001E47; suivant : 001E49Staphylococcus aureus targets the Duffy antigen receptor for chemokines (DARC) to lyse erythrocytes
Auteurs : András N. Spaan ; Tamara Reyes-Robles ; Cédric Badiou ; Sylvie Cochet ; Kristina M. Boguslawski ; Pauline Yoong ; Christopher J. Day ; Carla J. C. De Haas ; Kok P. M. Van Kessel ; François Vandenesch ; Michael P. Jennings ; Caroline Le Van Kim ; Yves Colin ; Jos A. G. Van Strijp ; Thomas Henry ; Victor J. TorresSource :
- Cell host & microbe [ 1931-3128 ] ; 2015.
Abstract
In order for
Url:
DOI: 10.1016/j.chom.2015.08.001
PubMed: 26320997
PubMed Central: 4578157
Links to Exploration step
PMC:4578157Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>Staphylococcus aureus</italic> targets the Duffy antigen receptor for chemokines (DARC) to lyse erythrocytes</title><author><name sortKey="Spaan, Andras N" sort="Spaan, Andras N" uniqKey="Spaan A" first="András N." last="Spaan">András N. Spaan</name><affiliation><nlm:aff id="A1">CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Reyes Robles, Tamara" sort="Reyes Robles, Tamara" uniqKey="Reyes Robles T" first="Tamara" last="Reyes-Robles">Tamara Reyes-Robles</name><affiliation><nlm:aff id="A4">Department of Microbiology, New York University School of Medicine, 10016 New York, USA</nlm:aff></affiliation></author><author><name sortKey="Badiou, Cedric" sort="Badiou, Cedric" uniqKey="Badiou C" first="Cédric" last="Badiou">Cédric Badiou</name><affiliation><nlm:aff id="A1">CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Cochet, Sylvie" sort="Cochet, Sylvie" uniqKey="Cochet S" first="Sylvie" last="Cochet">Sylvie Cochet</name><affiliation><nlm:aff id="A5">Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Boguslawski, Kristina M" sort="Boguslawski, Kristina M" uniqKey="Boguslawski K" first="Kristina M." last="Boguslawski">Kristina M. Boguslawski</name><affiliation><nlm:aff id="A4">Department of Microbiology, New York University School of Medicine, 10016 New York, USA</nlm:aff></affiliation></author><author><name sortKey="Yoong, Pauline" sort="Yoong, Pauline" uniqKey="Yoong P" first="Pauline" last="Yoong">Pauline Yoong</name><affiliation><nlm:aff id="A4">Department of Microbiology, New York University School of Medicine, 10016 New York, USA</nlm:aff></affiliation></author><author><name sortKey="Day, Christopher J" sort="Day, Christopher J" uniqKey="Day C" first="Christopher J." last="Day">Christopher J. Day</name><affiliation><nlm:aff id="A7">Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia</nlm:aff></affiliation></author><author><name sortKey="De Haas, Carla J C" sort="De Haas, Carla J C" uniqKey="De Haas C" first="Carla J. C." last="De Haas">Carla J. C. De Haas</name><affiliation><nlm:aff id="A3">Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Kessel, Kok P M" sort="Van Kessel, Kok P M" uniqKey="Van Kessel K" first="Kok P. M." last="Van Kessel">Kok P. M. Van Kessel</name><affiliation><nlm:aff id="A3">Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vandenesch, Francois" sort="Vandenesch, Francois" uniqKey="Vandenesch F" first="François" last="Vandenesch">François Vandenesch</name><affiliation><nlm:aff id="A1">CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Hospices Civils de Lyon, 69007 Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Jennings, Michael P" sort="Jennings, Michael P" uniqKey="Jennings M" first="Michael P." last="Jennings">Michael P. Jennings</name><affiliation><nlm:aff id="A7">Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia</nlm:aff></affiliation></author><author><name sortKey="Le Van Kim, Caroline" sort="Le Van Kim, Caroline" uniqKey="Le Van Kim C" first="Caroline" last="Le Van Kim">Caroline Le Van Kim</name><affiliation><nlm:aff id="A5">Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Colin, Yves" sort="Colin, Yves" uniqKey="Colin Y" first="Yves" last="Colin">Yves Colin</name><affiliation><nlm:aff id="A5">Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Van Strijp, Jos A G" sort="Van Strijp, Jos A G" uniqKey="Van Strijp J" first="Jos A. G." last="Van Strijp">Jos A. G. Van Strijp</name><affiliation><nlm:aff id="A3">Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Henry, Thomas" sort="Henry, Thomas" uniqKey="Henry T" first="Thomas" last="Henry">Thomas Henry</name><affiliation><nlm:aff id="A1">CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Torres, Victor J" sort="Torres, Victor J" uniqKey="Torres V" first="Victor J." last="Torres">Victor J. Torres</name><affiliation><nlm:aff id="A4">Department of Microbiology, New York University School of Medicine, 10016 New York, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26320997</idno><idno type="pmc">4578157</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578157</idno><idno type="RBID">PMC:4578157</idno><idno type="doi">10.1016/j.chom.2015.08.001</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001E48</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E48</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Staphylococcus aureus</italic> targets the Duffy antigen receptor for chemokines (DARC) to lyse erythrocytes</title><author><name sortKey="Spaan, Andras N" sort="Spaan, Andras N" uniqKey="Spaan A" first="András N." last="Spaan">András N. Spaan</name><affiliation><nlm:aff id="A1">CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Reyes Robles, Tamara" sort="Reyes Robles, Tamara" uniqKey="Reyes Robles T" first="Tamara" last="Reyes-Robles">Tamara Reyes-Robles</name><affiliation><nlm:aff id="A4">Department of Microbiology, New York University School of Medicine, 10016 New York, USA</nlm:aff></affiliation></author><author><name sortKey="Badiou, Cedric" sort="Badiou, Cedric" uniqKey="Badiou C" first="Cédric" last="Badiou">Cédric Badiou</name><affiliation><nlm:aff id="A1">CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Cochet, Sylvie" sort="Cochet, Sylvie" uniqKey="Cochet S" first="Sylvie" last="Cochet">Sylvie Cochet</name><affiliation><nlm:aff id="A5">Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Boguslawski, Kristina M" sort="Boguslawski, Kristina M" uniqKey="Boguslawski K" first="Kristina M." last="Boguslawski">Kristina M. Boguslawski</name><affiliation><nlm:aff id="A4">Department of Microbiology, New York University School of Medicine, 10016 New York, USA</nlm:aff></affiliation></author><author><name sortKey="Yoong, Pauline" sort="Yoong, Pauline" uniqKey="Yoong P" first="Pauline" last="Yoong">Pauline Yoong</name><affiliation><nlm:aff id="A4">Department of Microbiology, New York University School of Medicine, 10016 New York, USA</nlm:aff></affiliation></author><author><name sortKey="Day, Christopher J" sort="Day, Christopher J" uniqKey="Day C" first="Christopher J." last="Day">Christopher J. Day</name><affiliation><nlm:aff id="A7">Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia</nlm:aff></affiliation></author><author><name sortKey="De Haas, Carla J C" sort="De Haas, Carla J C" uniqKey="De Haas C" first="Carla J. C." last="De Haas">Carla J. C. De Haas</name><affiliation><nlm:aff id="A3">Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Kessel, Kok P M" sort="Van Kessel, Kok P M" uniqKey="Van Kessel K" first="Kok P. M." last="Van Kessel">Kok P. M. Van Kessel</name><affiliation><nlm:aff id="A3">Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vandenesch, Francois" sort="Vandenesch, Francois" uniqKey="Vandenesch F" first="François" last="Vandenesch">François Vandenesch</name><affiliation><nlm:aff id="A1">CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Hospices Civils de Lyon, 69007 Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Jennings, Michael P" sort="Jennings, Michael P" uniqKey="Jennings M" first="Michael P." last="Jennings">Michael P. Jennings</name><affiliation><nlm:aff id="A7">Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia</nlm:aff></affiliation></author><author><name sortKey="Le Van Kim, Caroline" sort="Le Van Kim, Caroline" uniqKey="Le Van Kim C" first="Caroline" last="Le Van Kim">Caroline Le Van Kim</name><affiliation><nlm:aff id="A5">Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Colin, Yves" sort="Colin, Yves" uniqKey="Colin Y" first="Yves" last="Colin">Yves Colin</name><affiliation><nlm:aff id="A5">Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Van Strijp, Jos A G" sort="Van Strijp, Jos A G" uniqKey="Van Strijp J" first="Jos A. G." last="Van Strijp">Jos A. G. Van Strijp</name><affiliation><nlm:aff id="A3">Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Henry, Thomas" sort="Henry, Thomas" uniqKey="Henry T" first="Thomas" last="Henry">Thomas Henry</name><affiliation><nlm:aff id="A1">CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Torres, Victor J" sort="Torres, Victor J" uniqKey="Torres V" first="Victor J." last="Torres">Victor J. Torres</name><affiliation><nlm:aff id="A4">Department of Microbiology, New York University School of Medicine, 10016 New York, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Cell host & microbe</title><idno type="ISSN">1931-3128</idno><idno type="eISSN">1934-6069</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><p id="P3">In order for <italic>Staphylococcus aureus</italic> to thrive inside the mammalian host, the bacterium has to overcome iron scarcity. <italic>S. aureus</italic> is thought to produce toxins that lyse erythrocytes, releasing hemoglobin, the most abundant iron source in mammals. Here we identify the Duffy antigen receptor for chemokines (DARC) as the receptor for the <italic>S. aureus</italic> hemolytic leukocidins LukED and HlgAB. By assessing human erythrocytes with <italic>DARC</italic> polymorphisms, we determined that HlgAB and LukED-mediated lysis directly relates to DARC expression. DARC is required for <italic>S. aureus</italic>-mediated lysis of human erythrocytes and DARC overexpression is sufficient to render cells susceptible to toxin-mediated lysis. HlgA and LukE bind directly to DARC through different regions, and by targeting DARC, HlgAB and LukED support <italic>S. aureus</italic> growth in a hemoglobin acquisition-dependent manner. These findings elucidate how <italic>S. aureus</italic> targets and lyses erythrocytes to release one of the scarcest nutrients within the mammalian host.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101302316</journal-id><journal-id journal-id-type="pubmed-jr-id">33345</journal-id><journal-id journal-id-type="nlm-ta">Cell Host Microbe</journal-id><journal-id journal-id-type="iso-abbrev">Cell Host Microbe</journal-id><journal-title-group><journal-title>Cell host & microbe</journal-title></journal-title-group><issn pub-type="ppub">1931-3128</issn><issn pub-type="epub">1934-6069</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26320997</article-id><article-id pub-id-type="pmc">4578157</article-id><article-id pub-id-type="doi">10.1016/j.chom.2015.08.001</article-id><article-id pub-id-type="manuscript">NIHMS713749</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title><italic>Staphylococcus aureus</italic> targets the Duffy antigen receptor for chemokines (DARC) to lyse erythrocytes</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Spaan</surname><given-names>András N.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Reyes-Robles</surname><given-names>Tamara</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Badiou</surname><given-names>Cédric</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Cochet</surname><given-names>Sylvie</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Boguslawski</surname><given-names>Kristina M.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Yoong</surname><given-names>Pauline</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Day</surname><given-names>Christopher J.</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>de Haas</surname><given-names>Carla J.C.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>van Kessel</surname><given-names>Kok P.M.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Vandenesch</surname><given-names>François</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Jennings</surname><given-names>Michael P.</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Le Van Kim</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Colin</surname><given-names>Yves</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>van Strijp</surname><given-names>Jos A.G.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Henry</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref rid="FN3" ref-type="author-notes">**</xref></contrib><contrib contrib-type="author"><name><surname>Torres</surname><given-names>Victor J.</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref rid="FN3" ref-type="author-notes">**</xref></contrib></contrib-group><aff id="A1"><label>1</label>CIRI, Inserm U1111, CNRS UMR 5308, Lyon, France</aff><aff id="A2"><label>2</label>Université Claude Bernard Lyon-1, Ecole Normale Supérieure, 69007 Lyon, France</aff><aff id="A3"><label>3</label>Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands</aff><aff id="A4"><label>4</label>Department of Microbiology, New York University School of Medicine, 10016 New York, USA</aff><aff id="A5"><label>5</label>Inserm U1134, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR_S1134, Paris, France</aff><aff id="A6"><label>6</label>Institut National de la Transfusion Sanguine, F-75739 Paris, France ; Laboratoire d’Excellence GR-Ex, 75238 Paris, France</aff><aff id="A7"><label>7</label>Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia</aff><aff id="A8"><label>8</label>Hospices Civils de Lyon, 69007 Lyon, France</aff><author-notes><corresp id="FN1">Correspondence: <email>thomas.henry@inserm.fr</email> or <email>victor.torres@nyumc.org</email></corresp><fn id="FN2" fn-type="equal"><label>*</label><p>These authors contributed equally to this work</p></fn><fn id="FN3"><label>**</label><p>Co senior authors</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>5</day><month>9</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>27</day><month>8</month><year>2015</year></pub-date><pub-date pub-type="ppub"><day>9</day><month>9</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>09</day><month>9</month><year>2016</year></pub-date><volume>18</volume><issue>3</issue><fpage>363</fpage><lpage>370</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.chom.2015.08.001</pmc-comment>
<abstract id="Abs1"><title>SUMMARY</title><p id="P3">In order for <italic>Staphylococcus aureus</italic> to thrive inside the mammalian host, the bacterium has to overcome iron scarcity. <italic>S. aureus</italic> is thought to produce toxins that lyse erythrocytes, releasing hemoglobin, the most abundant iron source in mammals. Here we identify the Duffy antigen receptor for chemokines (DARC) as the receptor for the <italic>S. aureus</italic> hemolytic leukocidins LukED and HlgAB. By assessing human erythrocytes with <italic>DARC</italic> polymorphisms, we determined that HlgAB and LukED-mediated lysis directly relates to DARC expression. DARC is required for <italic>S. aureus</italic>-mediated lysis of human erythrocytes and DARC overexpression is sufficient to render cells susceptible to toxin-mediated lysis. HlgA and LukE bind directly to DARC through different regions, and by targeting DARC, HlgAB and LukED support <italic>S. aureus</italic> growth in a hemoglobin acquisition-dependent manner. These findings elucidate how <italic>S. aureus</italic> targets and lyses erythrocytes to release one of the scarcest nutrients within the mammalian host.</p></abstract><abstract abstract-type="graphical" id="Abs2"><title>Graphical Abstract</title><p id="P4"><graphic xlink:href="nihms713749u1.jpg" position="anchor" orientation="portrait"></graphic></p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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