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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Stroke: Working toward a Prioritized World Agenda</title><author><name sortKey="Hachinski, Vladimir" sort="Hachinski, Vladimir" uniqKey="Hachinski V" first="Vladimir" last="Hachinski">Vladimir Hachinski</name><affiliation><nlm:aff id="A1">Department of Clinical Neurological Sciences, London Health Sciences Center, University of Western Ontario</nlm:aff></affiliation></author><author><name sortKey="Donnan, Geoffrey A" sort="Donnan, Geoffrey A" uniqKey="Donnan G" first="Geoffrey A." last="Donnan">Geoffrey A. Donnan</name><affiliation><nlm:aff id="A5">Florey Neurosciences Institutes, Carlton South Victoria</nlm:aff></affiliation></author><author><name sortKey="Gorelick, Philip B" sort="Gorelick, Philip B" uniqKey="Gorelick P" first="Philip B." last="Gorelick">Philip B. Gorelick</name><affiliation><nlm:aff id="A8">University of Illinois at Chicago, Chicago, Ill.</nlm:aff></affiliation></author><author><name sortKey="Hacke, Werner" sort="Hacke, Werner" uniqKey="Hacke W" first="Werner" last="Hacke">Werner Hacke</name><affiliation><nlm:aff id="A30">University of Heidelberg, Heidelberg</nlm:aff></affiliation></author><author><name sortKey="Cramer, Steven C" sort="Cramer, Steven C" uniqKey="Cramer S" first="Steven C." last="Cramer">Steven C. Cramer</name><affiliation><nlm:aff id="A10">University of California – Irvine, Orange, Calif.</nlm:aff></affiliation></author><author><name sortKey="Kaste, Markku" sort="Kaste, Markku" uniqKey="Kaste M" first="Markku" last="Kaste">Markku Kaste</name><affiliation><nlm:aff id="A33">Helsinki University Central Hospital, University of Helsinki</nlm:aff></affiliation></author><author><name sortKey="Fisher, Marc" sort="Fisher, Marc" uniqKey="Fisher M" first="Marc" last="Fisher">Marc Fisher</name><affiliation><nlm:aff id="A14">University of Massachusetts Medical School, Worcester, Mass.</nlm:aff></affiliation></author><author><name sortKey="Brainin, Michael" sort="Brainin, Michael" uniqKey="Brainin M" first="Michael" last="Brainin">Michael Brainin</name><affiliation><nlm:aff id="A36">University Donau-Universität Krems, Krems, Austria</nlm:aff></affiliation></author><author><name sortKey="Buchan, Alastair M" sort="Buchan, Alastair M" uniqKey="Buchan A" first="Alastair M." last="Buchan">Alastair M. Buchan</name><affiliation><nlm:aff id="A37">University of Oxford</nlm:aff></affiliation></author><author><name sortKey="Lo, Eng H" sort="Lo, Eng H" uniqKey="Lo E" first="Eng H." last="Lo">Eng H. Lo</name><affiliation><nlm:aff id="A15">Massachusetts General Hospital, Charlestown, Mass.</nlm:aff></affiliation></author><author><name sortKey="Skolnick, Brett E" sort="Skolnick, Brett E" uniqKey="Skolnick B" first="Brett E." last="Skolnick">Brett E. Skolnick</name><affiliation><nlm:aff id="A17">Novo Nordisk, Princeton, N.J.</nlm:aff></affiliation></author><author><name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L." last="Furie">Karen L. Furie</name><affiliation><nlm:aff id="A15">Massachusetts General Hospital, Charlestown, Mass.</nlm:aff></affiliation></author><author><name sortKey="Hankey, Graeme J" sort="Hankey, Graeme J" uniqKey="Hankey G" first="Graeme J." last="Hankey">Graeme J. Hankey</name><affiliation><nlm:aff id="A7">Royal Perth Hospital, Perth, W.A., Australia</nlm:aff></affiliation></author><author><name sortKey="Kivipelto, Miia" sort="Kivipelto, Miia" uniqKey="Kivipelto M" first="Miia" last="Kivipelto">Miia Kivipelto</name><affiliation><nlm:aff id="A41">Karolinska Institute, Stockholm</nlm:aff></affiliation></author><author><name sortKey="Morris, John" sort="Morris, John" uniqKey="Morris J" first="John" last="Morris">John Morris</name><affiliation><nlm:aff id="A18">Washington University School of Medicine, St. Louis, Mo.</nlm:aff></affiliation></author><author><name sortKey="Rothwell, Peter M" sort="Rothwell, Peter M" uniqKey="Rothwell P" first="Peter M." last="Rothwell">Peter M. Rothwell</name><affiliation><nlm:aff id="A38">John Radcliffe Hospital, Oxford</nlm:aff></affiliation></author><author><name sortKey="Sacco, Ralph L" sort="Sacco, Ralph L" uniqKey="Sacco R" first="Ralph L." last="Sacco">Ralph L. Sacco</name><affiliation><nlm:aff id="A19">President-elect, AHA, University of Miami, Miami, Fla.</nlm:aff></affiliation></author><author><name sortKey="Smith, Sidney C" sort="Smith, Sidney C" uniqKey="Smith S" first="Sidney C." last="Smith">Sidney C. Smith</name><affiliation><nlm:aff id="A21">Center for Cardiovascular Science and Medicine, University of North Carolina, Chapel Hill, N.C.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">President-elect, World Heart Federation, Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wang, Yulun" sort="Wang, Yulun" uniqKey="Wang Y" first="Yulun" last="Wang">Yulun Wang</name><affiliation><nlm:aff id="A12">InTouch Health, Goleta, Calif.</nlm:aff></affiliation></author><author><name sortKey="Bryer, Alan" sort="Bryer, Alan" uniqKey="Bryer A" first="Alan" last="Bryer">Alan Bryer</name><affiliation><nlm:aff id="A44">Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Ford, Gary A" sort="Ford, Gary A" uniqKey="Ford G" first="Gary A." last="Ford">Gary A. Ford</name><affiliation><nlm:aff id="A39">Newcastle University, Newcastle upon Tyne</nlm:aff></affiliation></author><author><name sortKey="Iadecola, Costantino" sort="Iadecola, Costantino" uniqKey="Iadecola C" first="Costantino" last="Iadecola">Costantino Iadecola</name><affiliation><nlm:aff id="A25">Weill Cornell Medical College, New York, N.Y.</nlm:aff></affiliation></author><author><name sortKey="Martins, Sheila C O" sort="Martins, Sheila C O" uniqKey="Martins S" first="Sheila C. O." last="Martins">Sheila C. O. Martins</name><affiliation><nlm:aff id="A45">Hospital De Clinicas, Porto Alegre, Brazil</nlm:aff></affiliation></author><author><name sortKey="Saver, Jeff" sort="Saver, Jeff" uniqKey="Saver J" first="Jeff" last="Saver">Jeff Saver</name><affiliation><nlm:aff id="A13">University of California at Los Angeles Stroke Center, Los Angeles, Calif.</nlm:aff></affiliation></author><author><name sortKey="Skvortsova, Veronika" sort="Skvortsova, Veronika" uniqKey="Skvortsova V" first="Veronika" last="Skvortsova">Veronika Skvortsova</name><affiliation><nlm:aff id="A46">Russian State Research Stroke Institute, Moscow, Russian Federation</nlm:aff></affiliation></author><author><name sortKey="Bayley, Mark" sort="Bayley, Mark" uniqKey="Bayley M" first="Mark" last="Bayley">Mark Bayley</name><affiliation><nlm:aff id="A3">Toronto Rehabilitation Institute, Toronto, Ont.</nlm:aff></affiliation></author><author><name sortKey="Bednar, Martin M" sort="Bednar, Martin M" uniqKey="Bednar M" first="Martin M." last="Bednar">Martin M. Bednar</name><affiliation><nlm:aff id="A26">Neuroscience Research Unit, Pfizer Inc., Groton, Conn.</nlm:aff></affiliation></author><author><name sortKey="Duncan, Pamela" sort="Duncan, Pamela" uniqKey="Duncan P" first="Pamela" last="Duncan">Pamela Duncan</name><affiliation><nlm:aff id="A22">Duke University, Durham, N.C.</nlm:aff></affiliation></author><author><name sortKey="Enney, Lori" sort="Enney, Lori" uniqKey="Enney L" first="Lori" last="Enney">Lori Enney</name><affiliation><nlm:aff id="A23">GlaxoSmithKline, Durham, N.C.</nlm:aff></affiliation></author><author><name sortKey="Finklestein, Seth" sort="Finklestein, Seth" uniqKey="Finklestein S" first="Seth" last="Finklestein">Seth Finklestein</name><affiliation><nlm:aff id="A16">Biotrofix, Inc., Waltham, Mass.</nlm:aff></affiliation></author><author><name sortKey="Jones, Theresa A" sort="Jones, Theresa A" uniqKey="Jones T" first="Theresa A." last="Jones">Theresa A. Jones</name><affiliation><nlm:aff id="A27">University of Texas at Austin, Austin, Tex.</nlm:aff></affiliation></author><author><name sortKey="Kalra, Lalit" sort="Kalra, Lalit" uniqKey="Kalra L" first="Lalit" last="Kalra">Lalit Kalra</name><affiliation><nlm:aff id="A40">Kings College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kleim, Jeff" sort="Kleim, Jeff" uniqKey="Kleim J" first="Jeff" last="Kleim">Jeff Kleim</name><affiliation><nlm:aff id="A20">University of Florida, Gainesville, Fla.</nlm:aff></affiliation></author><author><name sortKey="Nitkin, Ralph" sort="Nitkin, Ralph" uniqKey="Nitkin R" first="Ralph" last="Nitkin">Ralph Nitkin</name><affiliation><nlm:aff id="A28">National Center for Medical Rehabilitation, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Md.</nlm:aff></affiliation></author><author><name sortKey="Teasell, Robert" sort="Teasell, Robert" uniqKey="Teasell R" first="Robert" last="Teasell">Robert Teasell</name><affiliation><nlm:aff id="A2">St. Joseph’s Healthcare London, London, Ont.</nlm:aff></affiliation></author><author><name sortKey="Weiller, Cornelius" sort="Weiller, Cornelius" uniqKey="Weiller C" first="Cornelius" last="Weiller">Cornelius Weiller</name><affiliation><nlm:aff id="A31">University of Freiburg, Freiburg</nlm:aff></affiliation></author><author><name sortKey="Desai, Bhupat" sort="Desai, Bhupat" uniqKey="Desai B" first="Bhupat" last="Desai">Bhupat Desai</name><affiliation><nlm:aff id="A11">Pomona Valley Hospital Medical Center, Pomona, Calif.</nlm:aff></affiliation></author><author><name sortKey="Goldberg, Mark P" sort="Goldberg, Mark P" uniqKey="Goldberg M" first="Mark P." last="Goldberg">Mark P. Goldberg</name><affiliation><nlm:aff id="A18">Washington University School of Medicine, St. Louis, Mo.</nlm:aff></affiliation></author><author><name sortKey="Heiss, Wolf Dieter" sort="Heiss, Wolf Dieter" uniqKey="Heiss W" first="Wolf-Dieter" last="Heiss">Wolf-Dieter Heiss</name><affiliation><nlm:aff id="A32">Max Planck Institute for Neurological Research, Köln, Germany</nlm:aff></affiliation></author><author><name sortKey="Saarelma, Osmo" sort="Saarelma, Osmo" uniqKey="Saarelma O" first="Osmo" last="Saarelma">Osmo Saarelma</name><affiliation><nlm:aff id="A34">Terveystalo Medical Center</nlm:aff></affiliation></author><author><name sortKey="Schwamm, Lee H" sort="Schwamm, Lee H" uniqKey="Schwamm L" first="Lee H." last="Schwamm">Lee H. Schwamm</name><affiliation><nlm:aff id="A15">Massachusetts General Hospital, Charlestown, Mass.</nlm:aff></affiliation></author><author><name sortKey="Shinohara, Yukito" sort="Shinohara, Yukito" uniqKey="Shinohara Y" first="Yukito" last="Shinohara">Yukito Shinohara</name><affiliation><nlm:aff id="A47">Tachikawa Hospital, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Trivedi, Bhargava" sort="Trivedi, Bhargava" uniqKey="Trivedi B" first="Bhargava" last="Trivedi">Bhargava Trivedi</name><affiliation><nlm:aff id="A9">Southern Illinois Healthcare, Carbondale, Ill.</nlm:aff></affiliation></author><author><name sortKey="Wahlgren, Nils" sort="Wahlgren, Nils" uniqKey="Wahlgren N" first="Nils" last="Wahlgren">Nils Wahlgren</name><affiliation><nlm:aff id="A41">Karolinska Institute, Stockholm</nlm:aff></affiliation></author><author><name sortKey="Wong, Lawrence K" sort="Wong, Lawrence K" uniqKey="Wong L" first="Lawrence K." last="Wong">Lawrence K. Wong</name><affiliation><nlm:aff id="A48">Chinese University of Hong Kong, Sha Tin, Hong Kong, China</nlm:aff></affiliation></author><author><name sortKey="Hakim, Antoine" sort="Hakim, Antoine" uniqKey="Hakim A" first="Antoine" last="Hakim">Antoine Hakim</name><affiliation><nlm:aff id="A4">The Canadian Stroke Network, The University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Ont., Canada</nlm:aff></affiliation></author><author><name sortKey="Norrving, Bo" sort="Norrving, Bo" uniqKey="Norrving B" first="Bo" last="Norrving">Bo Norrving</name><affiliation><nlm:aff id="A42">Lund University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Prudhomme, Stephen" sort="Prudhomme, Stephen" uniqKey="Prudhomme S" first="Stephen" last="Prudhomme">Stephen Prudhomme</name><affiliation><nlm:aff id="A29">American Heart Association, Dallas, Tex., USA</nlm:aff></affiliation></author><author><name sortKey="Bornstein, Natan M" sort="Bornstein, Natan M" uniqKey="Bornstein N" first="Natan M." last="Bornstein">Natan M. Bornstein</name><affiliation><nlm:aff id="A49">Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel</nlm:aff></affiliation></author><author><name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M." last="Davis">Stephen M. Davis</name><affiliation><nlm:aff id="A6">Director of Neurology, Royal Melbourne Hospital and University of Melbourne, Melbourne, Vic.</nlm:aff></affiliation></author><author><name sortKey="Goldstein, Larry B" sort="Goldstein, Larry B" uniqKey="Goldstein L" first="Larry B." last="Goldstein">Larry B. Goldstein</name><affiliation><nlm:aff id="A24">Duke University and Durham VA Medical Center, Durham, N.C.</nlm:aff></affiliation></author><author><name sortKey="Leys, Didier" sort="Leys, Didier" uniqKey="Leys D" first="Didier" last="Leys">Didier Leys</name><affiliation><nlm:aff id="A50">University Lille Nord de France, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation><nlm:aff id="A35">University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20636706</idno><idno type="pmc">3712839</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712839</idno><idno type="RBID">PMC:3712839</idno><idno type="doi">10.1111/j.1747-4949.2010.00442.x</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001E41</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Stroke: Working toward a Prioritized World Agenda</title><author><name sortKey="Hachinski, Vladimir" sort="Hachinski, Vladimir" uniqKey="Hachinski V" first="Vladimir" last="Hachinski">Vladimir Hachinski</name><affiliation><nlm:aff id="A1">Department of Clinical Neurological Sciences, London Health Sciences Center, University of Western Ontario</nlm:aff></affiliation></author><author><name sortKey="Donnan, Geoffrey A" sort="Donnan, Geoffrey A" uniqKey="Donnan G" first="Geoffrey A." last="Donnan">Geoffrey A. Donnan</name><affiliation><nlm:aff id="A5">Florey Neurosciences Institutes, Carlton South Victoria</nlm:aff></affiliation></author><author><name sortKey="Gorelick, Philip B" sort="Gorelick, Philip B" uniqKey="Gorelick P" first="Philip B." last="Gorelick">Philip B. Gorelick</name><affiliation><nlm:aff id="A8">University of Illinois at Chicago, Chicago, Ill.</nlm:aff></affiliation></author><author><name sortKey="Hacke, Werner" sort="Hacke, Werner" uniqKey="Hacke W" first="Werner" last="Hacke">Werner Hacke</name><affiliation><nlm:aff id="A30">University of Heidelberg, Heidelberg</nlm:aff></affiliation></author><author><name sortKey="Cramer, Steven C" sort="Cramer, Steven C" uniqKey="Cramer S" first="Steven C." last="Cramer">Steven C. Cramer</name><affiliation><nlm:aff id="A10">University of California – Irvine, Orange, Calif.</nlm:aff></affiliation></author><author><name sortKey="Kaste, Markku" sort="Kaste, Markku" uniqKey="Kaste M" first="Markku" last="Kaste">Markku Kaste</name><affiliation><nlm:aff id="A33">Helsinki University Central Hospital, University of Helsinki</nlm:aff></affiliation></author><author><name sortKey="Fisher, Marc" sort="Fisher, Marc" uniqKey="Fisher M" first="Marc" last="Fisher">Marc Fisher</name><affiliation><nlm:aff id="A14">University of Massachusetts Medical School, Worcester, Mass.</nlm:aff></affiliation></author><author><name sortKey="Brainin, Michael" sort="Brainin, Michael" uniqKey="Brainin M" first="Michael" last="Brainin">Michael Brainin</name><affiliation><nlm:aff id="A36">University Donau-Universität Krems, Krems, Austria</nlm:aff></affiliation></author><author><name sortKey="Buchan, Alastair M" sort="Buchan, Alastair M" uniqKey="Buchan A" first="Alastair M." last="Buchan">Alastair M. Buchan</name><affiliation><nlm:aff id="A37">University of Oxford</nlm:aff></affiliation></author><author><name sortKey="Lo, Eng H" sort="Lo, Eng H" uniqKey="Lo E" first="Eng H." last="Lo">Eng H. Lo</name><affiliation><nlm:aff id="A15">Massachusetts General Hospital, Charlestown, Mass.</nlm:aff></affiliation></author><author><name sortKey="Skolnick, Brett E" sort="Skolnick, Brett E" uniqKey="Skolnick B" first="Brett E." last="Skolnick">Brett E. Skolnick</name><affiliation><nlm:aff id="A17">Novo Nordisk, Princeton, N.J.</nlm:aff></affiliation></author><author><name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L." last="Furie">Karen L. Furie</name><affiliation><nlm:aff id="A15">Massachusetts General Hospital, Charlestown, Mass.</nlm:aff></affiliation></author><author><name sortKey="Hankey, Graeme J" sort="Hankey, Graeme J" uniqKey="Hankey G" first="Graeme J." last="Hankey">Graeme J. Hankey</name><affiliation><nlm:aff id="A7">Royal Perth Hospital, Perth, W.A., Australia</nlm:aff></affiliation></author><author><name sortKey="Kivipelto, Miia" sort="Kivipelto, Miia" uniqKey="Kivipelto M" first="Miia" last="Kivipelto">Miia Kivipelto</name><affiliation><nlm:aff id="A41">Karolinska Institute, Stockholm</nlm:aff></affiliation></author><author><name sortKey="Morris, John" sort="Morris, John" uniqKey="Morris J" first="John" last="Morris">John Morris</name><affiliation><nlm:aff id="A18">Washington University School of Medicine, St. Louis, Mo.</nlm:aff></affiliation></author><author><name sortKey="Rothwell, Peter M" sort="Rothwell, Peter M" uniqKey="Rothwell P" first="Peter M." last="Rothwell">Peter M. Rothwell</name><affiliation><nlm:aff id="A38">John Radcliffe Hospital, Oxford</nlm:aff></affiliation></author><author><name sortKey="Sacco, Ralph L" sort="Sacco, Ralph L" uniqKey="Sacco R" first="Ralph L." last="Sacco">Ralph L. Sacco</name><affiliation><nlm:aff id="A19">President-elect, AHA, University of Miami, Miami, Fla.</nlm:aff></affiliation></author><author><name sortKey="Smith, Sidney C" sort="Smith, Sidney C" uniqKey="Smith S" first="Sidney C." last="Smith">Sidney C. Smith</name><affiliation><nlm:aff id="A21">Center for Cardiovascular Science and Medicine, University of North Carolina, Chapel Hill, N.C.</nlm:aff></affiliation><affiliation><nlm:aff id="A43">President-elect, World Heart Federation, Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wang, Yulun" sort="Wang, Yulun" uniqKey="Wang Y" first="Yulun" last="Wang">Yulun Wang</name><affiliation><nlm:aff id="A12">InTouch Health, Goleta, Calif.</nlm:aff></affiliation></author><author><name sortKey="Bryer, Alan" sort="Bryer, Alan" uniqKey="Bryer A" first="Alan" last="Bryer">Alan Bryer</name><affiliation><nlm:aff id="A44">Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Ford, Gary A" sort="Ford, Gary A" uniqKey="Ford G" first="Gary A." last="Ford">Gary A. Ford</name><affiliation><nlm:aff id="A39">Newcastle University, Newcastle upon Tyne</nlm:aff></affiliation></author><author><name sortKey="Iadecola, Costantino" sort="Iadecola, Costantino" uniqKey="Iadecola C" first="Costantino" last="Iadecola">Costantino Iadecola</name><affiliation><nlm:aff id="A25">Weill Cornell Medical College, New York, N.Y.</nlm:aff></affiliation></author><author><name sortKey="Martins, Sheila C O" sort="Martins, Sheila C O" uniqKey="Martins S" first="Sheila C. O." last="Martins">Sheila C. O. Martins</name><affiliation><nlm:aff id="A45">Hospital De Clinicas, Porto Alegre, Brazil</nlm:aff></affiliation></author><author><name sortKey="Saver, Jeff" sort="Saver, Jeff" uniqKey="Saver J" first="Jeff" last="Saver">Jeff Saver</name><affiliation><nlm:aff id="A13">University of California at Los Angeles Stroke Center, Los Angeles, Calif.</nlm:aff></affiliation></author><author><name sortKey="Skvortsova, Veronika" sort="Skvortsova, Veronika" uniqKey="Skvortsova V" first="Veronika" last="Skvortsova">Veronika Skvortsova</name><affiliation><nlm:aff id="A46">Russian State Research Stroke Institute, Moscow, Russian Federation</nlm:aff></affiliation></author><author><name sortKey="Bayley, Mark" sort="Bayley, Mark" uniqKey="Bayley M" first="Mark" last="Bayley">Mark Bayley</name><affiliation><nlm:aff id="A3">Toronto Rehabilitation Institute, Toronto, Ont.</nlm:aff></affiliation></author><author><name sortKey="Bednar, Martin M" sort="Bednar, Martin M" uniqKey="Bednar M" first="Martin M." last="Bednar">Martin M. Bednar</name><affiliation><nlm:aff id="A26">Neuroscience Research Unit, Pfizer Inc., Groton, Conn.</nlm:aff></affiliation></author><author><name sortKey="Duncan, Pamela" sort="Duncan, Pamela" uniqKey="Duncan P" first="Pamela" last="Duncan">Pamela Duncan</name><affiliation><nlm:aff id="A22">Duke University, Durham, N.C.</nlm:aff></affiliation></author><author><name sortKey="Enney, Lori" sort="Enney, Lori" uniqKey="Enney L" first="Lori" last="Enney">Lori Enney</name><affiliation><nlm:aff id="A23">GlaxoSmithKline, Durham, N.C.</nlm:aff></affiliation></author><author><name sortKey="Finklestein, Seth" sort="Finklestein, Seth" uniqKey="Finklestein S" first="Seth" last="Finklestein">Seth Finklestein</name><affiliation><nlm:aff id="A16">Biotrofix, Inc., Waltham, Mass.</nlm:aff></affiliation></author><author><name sortKey="Jones, Theresa A" sort="Jones, Theresa A" uniqKey="Jones T" first="Theresa A." last="Jones">Theresa A. Jones</name><affiliation><nlm:aff id="A27">University of Texas at Austin, Austin, Tex.</nlm:aff></affiliation></author><author><name sortKey="Kalra, Lalit" sort="Kalra, Lalit" uniqKey="Kalra L" first="Lalit" last="Kalra">Lalit Kalra</name><affiliation><nlm:aff id="A40">Kings College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kleim, Jeff" sort="Kleim, Jeff" uniqKey="Kleim J" first="Jeff" last="Kleim">Jeff Kleim</name><affiliation><nlm:aff id="A20">University of Florida, Gainesville, Fla.</nlm:aff></affiliation></author><author><name sortKey="Nitkin, Ralph" sort="Nitkin, Ralph" uniqKey="Nitkin R" first="Ralph" last="Nitkin">Ralph Nitkin</name><affiliation><nlm:aff id="A28">National Center for Medical Rehabilitation, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Md.</nlm:aff></affiliation></author><author><name sortKey="Teasell, Robert" sort="Teasell, Robert" uniqKey="Teasell R" first="Robert" last="Teasell">Robert Teasell</name><affiliation><nlm:aff id="A2">St. Joseph’s Healthcare London, London, Ont.</nlm:aff></affiliation></author><author><name sortKey="Weiller, Cornelius" sort="Weiller, Cornelius" uniqKey="Weiller C" first="Cornelius" last="Weiller">Cornelius Weiller</name><affiliation><nlm:aff id="A31">University of Freiburg, Freiburg</nlm:aff></affiliation></author><author><name sortKey="Desai, Bhupat" sort="Desai, Bhupat" uniqKey="Desai B" first="Bhupat" last="Desai">Bhupat Desai</name><affiliation><nlm:aff id="A11">Pomona Valley Hospital Medical Center, Pomona, Calif.</nlm:aff></affiliation></author><author><name sortKey="Goldberg, Mark P" sort="Goldberg, Mark P" uniqKey="Goldberg M" first="Mark P." last="Goldberg">Mark P. Goldberg</name><affiliation><nlm:aff id="A18">Washington University School of Medicine, St. Louis, Mo.</nlm:aff></affiliation></author><author><name sortKey="Heiss, Wolf Dieter" sort="Heiss, Wolf Dieter" uniqKey="Heiss W" first="Wolf-Dieter" last="Heiss">Wolf-Dieter Heiss</name><affiliation><nlm:aff id="A32">Max Planck Institute for Neurological Research, Köln, Germany</nlm:aff></affiliation></author><author><name sortKey="Saarelma, Osmo" sort="Saarelma, Osmo" uniqKey="Saarelma O" first="Osmo" last="Saarelma">Osmo Saarelma</name><affiliation><nlm:aff id="A34">Terveystalo Medical Center</nlm:aff></affiliation></author><author><name sortKey="Schwamm, Lee H" sort="Schwamm, Lee H" uniqKey="Schwamm L" first="Lee H." last="Schwamm">Lee H. Schwamm</name><affiliation><nlm:aff id="A15">Massachusetts General Hospital, Charlestown, Mass.</nlm:aff></affiliation></author><author><name sortKey="Shinohara, Yukito" sort="Shinohara, Yukito" uniqKey="Shinohara Y" first="Yukito" last="Shinohara">Yukito Shinohara</name><affiliation><nlm:aff id="A47">Tachikawa Hospital, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Trivedi, Bhargava" sort="Trivedi, Bhargava" uniqKey="Trivedi B" first="Bhargava" last="Trivedi">Bhargava Trivedi</name><affiliation><nlm:aff id="A9">Southern Illinois Healthcare, Carbondale, Ill.</nlm:aff></affiliation></author><author><name sortKey="Wahlgren, Nils" sort="Wahlgren, Nils" uniqKey="Wahlgren N" first="Nils" last="Wahlgren">Nils Wahlgren</name><affiliation><nlm:aff id="A41">Karolinska Institute, Stockholm</nlm:aff></affiliation></author><author><name sortKey="Wong, Lawrence K" sort="Wong, Lawrence K" uniqKey="Wong L" first="Lawrence K." last="Wong">Lawrence K. Wong</name><affiliation><nlm:aff id="A48">Chinese University of Hong Kong, Sha Tin, Hong Kong, China</nlm:aff></affiliation></author><author><name sortKey="Hakim, Antoine" sort="Hakim, Antoine" uniqKey="Hakim A" first="Antoine" last="Hakim">Antoine Hakim</name><affiliation><nlm:aff id="A4">The Canadian Stroke Network, The University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Ont., Canada</nlm:aff></affiliation></author><author><name sortKey="Norrving, Bo" sort="Norrving, Bo" uniqKey="Norrving B" first="Bo" last="Norrving">Bo Norrving</name><affiliation><nlm:aff id="A42">Lund University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Prudhomme, Stephen" sort="Prudhomme, Stephen" uniqKey="Prudhomme S" first="Stephen" last="Prudhomme">Stephen Prudhomme</name><affiliation><nlm:aff id="A29">American Heart Association, Dallas, Tex., USA</nlm:aff></affiliation></author><author><name sortKey="Bornstein, Natan M" sort="Bornstein, Natan M" uniqKey="Bornstein N" first="Natan M." last="Bornstein">Natan M. Bornstein</name><affiliation><nlm:aff id="A49">Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel</nlm:aff></affiliation></author><author><name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M." last="Davis">Stephen M. Davis</name><affiliation><nlm:aff id="A6">Director of Neurology, Royal Melbourne Hospital and University of Melbourne, Melbourne, Vic.</nlm:aff></affiliation></author><author><name sortKey="Goldstein, Larry B" sort="Goldstein, Larry B" uniqKey="Goldstein L" first="Larry B." last="Goldstein">Larry B. Goldstein</name><affiliation><nlm:aff id="A24">Duke University and Durham VA Medical Center, Durham, N.C.</nlm:aff></affiliation></author><author><name sortKey="Leys, Didier" sort="Leys, Didier" uniqKey="Leys D" first="Didier" last="Leys">Didier Leys</name><affiliation><nlm:aff id="A50">University Lille Nord de France, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation><nlm:aff id="A35">University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author></analytic><series><title level="j">International journal of stroke : official journal of the International Stroke Society</title><idno type="ISSN">1747-4930</idno><idno type="eISSN">1747-4949</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background and Purpose</title><p id="P13">The aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke.</p></sec><sec id="S2"><title>Methods</title><p id="P14">Preliminary work was performed by 7 working groups of stroke leaders followed by a synergium (a forum for working synergistically together) with approximately 100 additional participants. The resulting draft document had further input from contributors outside the synergium.</p></sec><sec id="S3"><title>Results</title><p id="P15">Recommendations of the Synergium are: <italic>Basic Science, Drug Development and Technology:</italic> There is a need to develop: (1) New systems of working together to break down the prevalent ‘silo’ mentality; (2) New models of vertically integrated basic, clinical, and epidemiological disciplines; and (3) Efficient methods of identifying other relevant areas of science. <italic>Stroke Prevention:</italic> (1) Establish a global chronic disease prevention initiative with stroke as a major focus. (2) Recognize not only abrupt clinical stroke, but subtle subclinical stroke, the commonest type of cerebrovascular disease, leading to impairments of executive function. (3) Develop, implement and evaluate a population approach for stroke prevention. (4) Develop public health communication strategies using traditional and novel (e.g., social media/marketing) techniques. <italic>Acute Stroke Management:</italic> Continue the establishment of stroke centers, stroke units, regional systems of emergency stroke care and telestroke networks. <italic>Brain Recovery and Rehabilitation:</italic> (1) Translate best neuroscience, including animal and human studies, into poststroke recovery research and clinical care. (2) Standardize poststroke rehabilitation based on best evidence. (3) Develop consensus on, then implementation of, standardized clinical and surrogate assessments. (4) Carry out rigorous clinical research to advance stroke recovery. <italic>Into the 21st Century: Web, Technology and Communications:</italic> (1) Work toward global unrestricted access to stroke-related information. (2) Build centralized electronic archives and registries. <italic>Foster Cooperation Among Stakeholders</italic> (large stroke organizations, nongovernmental organizations, governments, patient organizations and industry) to enhance stroke care. <italic>Educate and energize professionals, patients, the public and policy makers</italic> by using a ‘Brain Health’ concept that enables promotion of preventive measures.</p></sec><sec id="S4"><title>Conclusions</title><p id="P16">To accelerate progress in stroke, we must reach beyond the current status scientifically, conceptually, and pragmatically. Advances can be made not only by doing, but ceasing to do. Significant savings in time, money, and effort could result from discontinuing practices driven by unsubstantiated opinion, unproven approaches, and financial gain. Systematic integration of knowledge into programs coupled with careful evaluation can speed the pace of progress</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101274068</journal-id><journal-id journal-id-type="pubmed-jr-id">34603</journal-id><journal-id journal-id-type="nlm-ta">Int J Stroke</journal-id><journal-id journal-id-type="iso-abbrev">Int J Stroke</journal-id><journal-title-group><journal-title>International journal of stroke : official journal of the International Stroke Society</journal-title></journal-title-group><issn pub-type="ppub">1747-4930</issn><issn pub-type="epub">1747-4949</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20636706</article-id><article-id pub-id-type="pmc">3712839</article-id><article-id pub-id-type="doi">10.1111/j.1747-4949.2010.00442.x</article-id><article-id pub-id-type="manuscript">NIHMS484423</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Stroke: Working toward a Prioritized World 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rid="FN7">e</xref></contrib><contrib contrib-type="author"><name><surname>Trivedi</surname><given-names>Bhargava</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref ref-type="author-notes" rid="FN7">e</xref></contrib><contrib contrib-type="author"><name><surname>Wahlgren</surname><given-names>Nils</given-names></name><xref ref-type="aff" rid="A41">41</xref><xref ref-type="author-notes" rid="FN7">e</xref></contrib><contrib contrib-type="author"><name><surname>Wong</surname><given-names>Lawrence K.</given-names></name><xref ref-type="aff" rid="A48">48</xref><xref ref-type="author-notes" rid="FN7">e</xref></contrib><contrib contrib-type="author"><name><surname>Hakim</surname><given-names>Antoine</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="author-notes" rid="FN8">f</xref></contrib><contrib contrib-type="author"><name><surname>Norrving</surname><given-names>Bo</given-names></name><xref ref-type="aff" rid="A42">42</xref><xref ref-type="author-notes" rid="FN8">f</xref></contrib><contrib contrib-type="author"><name><surname>Prudhomme</surname><given-names>Stephen</given-names></name><xref ref-type="aff" rid="A29">29</xref><xref ref-type="author-notes" rid="FN8">f</xref></contrib><contrib contrib-type="author"><name><surname>Bornstein</surname><given-names>Natan M.</given-names></name><xref ref-type="aff" rid="A49">49</xref><xref ref-type="author-notes" rid="FN9">g</xref></contrib><contrib contrib-type="author"><name><surname>Davis</surname><given-names>Stephen M.</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="author-notes" rid="FN9">g</xref></contrib><contrib contrib-type="author"><name><surname>Goldstein</surname><given-names>Larry B.</given-names></name><xref ref-type="aff" rid="A24">24</xref><xref ref-type="author-notes" rid="FN9">g</xref></contrib><contrib contrib-type="author"><name><surname>Leys</surname><given-names>Didier</given-names></name><xref ref-type="aff" rid="A50">50</xref><xref ref-type="author-notes" rid="FN9">g</xref></contrib><contrib contrib-type="author"><name><surname>Tuomilehto</surname><given-names>Jaakko</given-names></name><xref ref-type="aff" rid="A35">35</xref><xref ref-type="author-notes" rid="FN9">g</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Clinical Neurological Sciences, London Health Sciences Center, University of Western Ontario</aff><aff id="A2"><label>2</label>St. Joseph’s Healthcare London, London, Ont.</aff><aff id="A3"><label>3</label>Toronto Rehabilitation Institute, Toronto, Ont.</aff><aff id="A4"><label>4</label>The Canadian Stroke Network, The University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Ont., Canada</aff><aff id="A5"><label>5</label>Florey Neurosciences Institutes, Carlton South Victoria</aff><aff id="A6"><label>6</label>Director of Neurology, Royal Melbourne Hospital and University of Melbourne, Melbourne, Vic.</aff><aff id="A7"><label>7</label>Royal Perth Hospital, Perth, W.A., Australia</aff><aff id="A8"><label>8</label>University of Illinois at Chicago, Chicago, Ill.</aff><aff id="A9"><label>9</label>Southern Illinois Healthcare, Carbondale, Ill.</aff><aff id="A10"><label>10</label>University of California – Irvine, Orange, Calif.</aff><aff id="A11"><label>11</label>Pomona Valley Hospital Medical Center, Pomona, Calif.</aff><aff id="A12"><label>12</label>InTouch Health, Goleta, Calif.</aff><aff id="A13"><label>13</label>University of California at Los Angeles Stroke Center, Los Angeles, Calif.</aff><aff id="A14"><label>14</label>University of Massachusetts Medical School, Worcester, Mass.</aff><aff id="A15"><label>15</label>Massachusetts General Hospital, Charlestown, Mass.</aff><aff id="A16"><label>16</label>Biotrofix, Inc., Waltham, Mass.</aff><aff id="A17"><label>17</label>Novo Nordisk, Princeton, N.J.</aff><aff id="A18"><label>18</label>Washington University School of Medicine, St. Louis, Mo.</aff><aff id="A19"><label>19</label>President-elect, AHA, University of Miami, Miami, Fla.</aff><aff id="A20"><label>20</label>University of Florida, Gainesville, Fla.</aff><aff id="A21"><label>21</label>Center for Cardiovascular Science and Medicine, University of North Carolina, Chapel Hill, N.C.</aff><aff id="A22"><label>22</label>Duke University, Durham, N.C.</aff><aff id="A23"><label>23</label>GlaxoSmithKline, Durham, N.C.</aff><aff id="A24"><label>24</label>Duke University and Durham VA Medical Center, Durham, N.C.</aff><aff id="A25"><label>25</label>Weill Cornell Medical College, New York, N.Y.</aff><aff id="A26"><label>26</label>Neuroscience Research Unit, Pfizer Inc., Groton, Conn.</aff><aff id="A27"><label>27</label>University of Texas at Austin, Austin, Tex.</aff><aff id="A28"><label>28</label>National Center for Medical Rehabilitation, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Md.</aff><aff id="A29"><label>29</label>American Heart Association, Dallas, Tex., USA</aff><aff id="A30"><label>30</label>University of Heidelberg, Heidelberg</aff><aff id="A31"><label>31</label>University of Freiburg, Freiburg</aff><aff id="A32"><label>32</label>Max Planck Institute for Neurological Research, Köln, Germany</aff><aff id="A33"><label>33</label>Helsinki University Central Hospital, University of Helsinki</aff><aff id="A34"><label>34</label>Terveystalo Medical Center</aff><aff id="A35"><label>35</label>University of Helsinki, Helsinki, Finland</aff><aff id="A36"><label>36</label>University Donau-Universität Krems, Krems, Austria</aff><aff id="A37"><label>37</label>University of Oxford</aff><aff id="A38"><label>38</label>John Radcliffe Hospital, Oxford</aff><aff id="A39"><label>39</label>Newcastle University, Newcastle upon Tyne</aff><aff id="A40"><label>40</label>Kings College London, London, UK</aff><aff id="A41"><label>41</label>Karolinska Institute, Stockholm</aff><aff id="A42"><label>42</label>Lund University Hospital, Lund, Sweden</aff><aff id="A43"><label>43</label>President-elect, World Heart Federation, Geneva, Switzerland</aff><aff id="A44"><label>44</label>Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa</aff><aff id="A45"><label>45</label>Hospital De Clinicas, Porto Alegre, Brazil</aff><aff id="A46"><label>46</label>Russian State Research Stroke Institute, Moscow, Russian Federation</aff><aff id="A47"><label>47</label>Tachikawa Hospital, Tokyo, Japan</aff><aff id="A48"><label>48</label>Chinese University of Hong Kong, Sha Tin, Hong Kong, China</aff><aff id="A49"><label>49</label>Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel</aff><aff id="A50"><label>50</label>University Lille Nord de France, Lille, France</aff><author-notes><fn id="FN1"><p id="P1">Vladimir Hachinski, MD, FRCPC, DSc, University of Western Ontario, University Hospital, 339 Windermere Road, London, Ont. N6A 5A5 (Canada), <email>Vladimir.Hachinski@lhsc.on.ca</email></p></fn><fn id="FN2"><p id="P2">Working Groups:</p></fn><fn id="FN3"><label>a</label><p id="P3">Basic Science, Drug Development, and Technology</p></fn><fn id="FN4"><label>b</label><p id="P4">Stroke Prevention: Broadening the Approach and Intensifying the Efforts</p></fn><fn id="FN5"><label>c</label><p id="P5">Acute Stroke Management: Applying and Expanding What We Know</p></fn><fn id="FN6"><label>d</label><p id="P6">Brain Recovery and Rehabilitation: Harnessing the Regenerative Powers of the Brain and the Individual</p></fn><fn id="FN7"><label>e</label><p id="P7">Into the 21st Century: The Web, Technology, and Communications: New Tools for Progress</p></fn><fn id="FN8"><label>f</label><p id="P8">Fostering Cooperation Among Stakeholders to Enhance Stroke Care</p></fn><fn id="FN9"><label>g</label><p id="P9">Educating and Energizing Professionals, Patients, the Public, and Policymakers</p></fn><fn id="FN10"><label>h</label><p id="P10">The coordinator of each group.</p></fn><fn id="FN11" fn-type="equal"><p id="P11">The work of the coordinators is deemed to have been equal.</p></fn><fn id="FN12"><p id="P12">The other authors are listed according to the sequence of their groups and alphabetically, and their work is also deemed to be equal to each other’s.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>6</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>16</day><month>7</month><year>2013</year></pub-date><volume>5</volume><issue>4</issue><fpage>238</fpage><lpage>256</lpage><permissions><copyright-statement>© 2010 American Heart Association. Inc.</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><sec id="S1"><title>Background and Purpose</title><p id="P13">The aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke.</p></sec><sec id="S2"><title>Methods</title><p id="P14">Preliminary work was performed by 7 working groups of stroke leaders followed by a synergium (a forum for working synergistically together) with approximately 100 additional participants. The resulting draft document had further input from contributors outside the synergium.</p></sec><sec id="S3"><title>Results</title><p id="P15">Recommendations of the Synergium are: <italic>Basic Science, Drug Development and Technology:</italic> There is a need to develop: (1) New systems of working together to break down the prevalent ‘silo’ mentality; (2) New models of vertically integrated basic, clinical, and epidemiological disciplines; and (3) Efficient methods of identifying other relevant areas of science. <italic>Stroke Prevention:</italic> (1) Establish a global chronic disease prevention initiative with stroke as a major focus. (2) Recognize not only abrupt clinical stroke, but subtle subclinical stroke, the commonest type of cerebrovascular disease, leading to impairments of executive function. (3) Develop, implement and evaluate a population approach for stroke prevention. (4) Develop public health communication strategies using traditional and novel (e.g., social media/marketing) techniques. <italic>Acute Stroke Management:</italic> Continue the establishment of stroke centers, stroke units, regional systems of emergency stroke care and telestroke networks. <italic>Brain Recovery and Rehabilitation:</italic> (1) Translate best neuroscience, including animal and human studies, into poststroke recovery research and clinical care. (2) Standardize poststroke rehabilitation based on best evidence. (3) Develop consensus on, then implementation of, standardized clinical and surrogate assessments. (4) Carry out rigorous clinical research to advance stroke recovery. <italic>Into the 21st Century: Web, Technology and Communications:</italic> (1) Work toward global unrestricted access to stroke-related information. (2) Build centralized electronic archives and registries. <italic>Foster Cooperation Among Stakeholders</italic> (large stroke organizations, nongovernmental organizations, governments, patient organizations and industry) to enhance stroke care. <italic>Educate and energize professionals, patients, the public and policy makers</italic> by using a ‘Brain Health’ concept that enables promotion of preventive measures.</p></sec><sec id="S4"><title>Conclusions</title><p id="P16">To accelerate progress in stroke, we must reach beyond the current status scientifically, conceptually, and pragmatically. Advances can be made not only by doing, but ceasing to do. Significant savings in time, money, and effort could result from discontinuing practices driven by unsubstantiated opinion, unproven approaches, and financial gain. Systematic integration of knowledge into programs coupled with careful evaluation can speed the pace of progress</p></sec></abstract><kwd-group><kwd>Prevention</kwd><kwd>Rehabilitation</kwd><kwd>Stroke</kwd><kwd>Translational</kwd><kwd>Treatment</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source><award-id>RC2 NS069335 || NS</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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