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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Short-term training alters the control of mitochondrial respiration rate before maximal oxidative ATP synthesis</title><author><name sortKey="Layec, Gwenael" sort="Layec, Gwenael" uniqKey="Layec G" first="Gwenael" last="Layec">Gwenael Layec</name><affiliation><nlm:aff id="A1">Department of Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Geriatric Research, Education, and Clinical Center, George E. Whalen VA Medical Center, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Haseler, Luke J" sort="Haseler, Luke J" uniqKey="Haseler L" first="Luke J." last="Haseler">Luke J. Haseler</name><affiliation><nlm:aff id="A3">Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Queensland Australia</nlm:aff></affiliation></author><author><name sortKey="Hoff, Jan" sort="Hoff, Jan" uniqKey="Hoff J" first="Jan" last="Hoff">Jan Hoff</name><affiliation><nlm:aff id="A4">Department of Medicine, Norwegian University of Science and Technology, Trondheim, Norway</nlm:aff></affiliation></author><author><name sortKey="Hart, Corey R" sort="Hart, Corey R" uniqKey="Hart C" first="Corey R." last="Hart">Corey R. Hart</name><affiliation><nlm:aff id="A1">Department of Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Geriatric Research, Education, and Clinical Center, George E. Whalen VA Medical Center, Salt Lake City, Utah, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Exercise and Sport Science, University of Utah, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Liu, Xin" sort="Liu, Xin" uniqKey="Liu X" first="Xin" last="Liu">Xin Liu</name><affiliation><nlm:aff id="A6">Department of Radiology and Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Le Fur, Yann" sort="Le Fur, Yann" uniqKey="Le Fur Y" first="Yann" last="Le Fur">Yann Le Fur</name><affiliation><nlm:aff id="A7">Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 7339, Faculté de Médecine de Marseille, Marseille, France</nlm:aff></affiliation></author><author><name sortKey="Jeong, Eun Kee" sort="Jeong, Eun Kee" uniqKey="Jeong E" first="Eun-Kee" last="Jeong">Eun-Kee Jeong</name><affiliation><nlm:aff id="A6">Department of Radiology and Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Richardson, Russell S" sort="Richardson, Russell S" uniqKey="Richardson R" first="Russell S." last="Richardson">Russell S. Richardson</name><affiliation><nlm:aff id="A1">Department of Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Geriatric Research, Education, and Clinical Center, George E. Whalen VA Medical Center, Salt Lake City, Utah, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Exercise and Sport Science, University of Utah, Salt Lake City, Utah, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23582030</idno><idno type="pmc">3725772</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725772</idno><idno type="RBID">PMC:3725772</idno><idno type="doi">10.1111/apha.12103</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001E40</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E40</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Short-term training alters the control of mitochondrial respiration rate before maximal oxidative ATP synthesis</title><author><name sortKey="Layec, Gwenael" sort="Layec, Gwenael" uniqKey="Layec G" first="Gwenael" last="Layec">Gwenael Layec</name><affiliation><nlm:aff id="A1">Department of Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Geriatric Research, Education, and Clinical Center, George E. Whalen VA Medical Center, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Haseler, Luke J" sort="Haseler, Luke J" uniqKey="Haseler L" first="Luke J." last="Haseler">Luke J. Haseler</name><affiliation><nlm:aff id="A3">Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Queensland Australia</nlm:aff></affiliation></author><author><name sortKey="Hoff, Jan" sort="Hoff, Jan" uniqKey="Hoff J" first="Jan" last="Hoff">Jan Hoff</name><affiliation><nlm:aff id="A4">Department of Medicine, Norwegian University of Science and Technology, Trondheim, Norway</nlm:aff></affiliation></author><author><name sortKey="Hart, Corey R" sort="Hart, Corey R" uniqKey="Hart C" first="Corey R." last="Hart">Corey R. Hart</name><affiliation><nlm:aff id="A1">Department of Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Geriatric Research, Education, and Clinical Center, George E. Whalen VA Medical Center, Salt Lake City, Utah, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Exercise and Sport Science, University of Utah, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Liu, Xin" sort="Liu, Xin" uniqKey="Liu X" first="Xin" last="Liu">Xin Liu</name><affiliation><nlm:aff id="A6">Department of Radiology and Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Le Fur, Yann" sort="Le Fur, Yann" uniqKey="Le Fur Y" first="Yann" last="Le Fur">Yann Le Fur</name><affiliation><nlm:aff id="A7">Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 7339, Faculté de Médecine de Marseille, Marseille, France</nlm:aff></affiliation></author><author><name sortKey="Jeong, Eun Kee" sort="Jeong, Eun Kee" uniqKey="Jeong E" first="Eun-Kee" last="Jeong">Eun-Kee Jeong</name><affiliation><nlm:aff id="A6">Department of Radiology and Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Richardson, Russell S" sort="Richardson, Russell S" uniqKey="Richardson R" first="Russell S." last="Richardson">Russell S. Richardson</name><affiliation><nlm:aff id="A1">Department of Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Geriatric Research, Education, and Clinical Center, George E. Whalen VA Medical Center, Salt Lake City, Utah, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Exercise and Sport Science, University of Utah, Salt Lake City, Utah, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Acta physiologica (Oxford, England)</title><idno type="ISSN">1748-1708</idno><idno type="eISSN">1748-1716</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S990"><title>Aim</title><p id="P1">Short-term exercise training may induce metabolic and performance adaptations before any changes in mitochondrial enzyme potential. However, there has not been a study that has directly assessed changes in mitochondrial oxidative capacity or metabolic control as a consequence of such training <italic>in vivo</italic>. Therefore, we used <sup>31</sup>P-magnetic resonance spectroscopy (<sup>31</sup>P-MRS) to examine the effect of short-term plantar flexion exercise training on phosphocreatine (PCr) recovery kinetics and the control of respiration rate.</p></sec><sec id="S991"><title>Method</title><p id="P990">To this aim, we investigated 12 healthy men, experienced with this exercise modality (TRA), and 7 time-control subjects (TC).</p></sec><sec id="S992"><title>Results</title><p id="P991">After 5 days of training, maximum work rate during incremental plantar flexion exercise was significantly improved (<italic>P</italic> < 0.01). During the recovery period, the maximal rate of oxidative ATP synthesis (PRE: 28 ± 13 mM.min<sup>−1</sup>; POST: 26 ± 15 mM.min<sup>−1</sup>) and the PCr recovery time constant (PRE: 31 ± 19 s; POST: 29 ± 16) were not significantly altered. In contrast, the Hill coefficient (<italic>n<sub>H</sub></italic>) describing the cooperativity between respiration rate and ADP was significantly increased in TRA (PRE:<italic>n<sub>H</sub></italic> = 2.7 ± 1.4; POST: <italic>n<sub>H</sub></italic> = 3.4 ± 1.9, <italic>P</italic> < 0.05). Meanwhile, there were no systematic variations in any of these variables in TC.</p></sec><sec id="S993"><title>Conclusion</title><p id="P992">This study reveals that 5 days of training induces rapid adaptation in the allosteric control of respiration rate by ADP before any substantial improvement in muscle oxidative capacity occurs.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101262545</journal-id><journal-id journal-id-type="pubmed-jr-id">32806</journal-id><journal-id journal-id-type="nlm-ta">Acta Physiol (Oxf)</journal-id><journal-id journal-id-type="iso-abbrev">Acta Physiol (Oxf)</journal-id><journal-title-group><journal-title>Acta physiologica (Oxford, England)</journal-title></journal-title-group><issn pub-type="ppub">1748-1708</issn><issn pub-type="epub">1748-1716</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23582030</article-id><article-id pub-id-type="pmc">3725772</article-id><article-id pub-id-type="doi">10.1111/apha.12103</article-id><article-id pub-id-type="manuscript">NIHMS467820</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Short-term training alters the control of mitochondrial respiration rate before maximal oxidative ATP synthesis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Layec</surname><given-names>Gwenael</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Haseler</surname><given-names>Luke J.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Hoff</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Hart</surname><given-names>Corey R.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Xin</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Le Fur</surname><given-names>Yann</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Jeong</surname><given-names>Eun-Kee</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Richardson</surname><given-names>Russell S.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A5">5</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA</aff><aff id="A2"><label>2</label>Geriatric Research, Education, and Clinical Center, George E. Whalen VA Medical Center, Salt Lake City, Utah, USA</aff><aff id="A3"><label>3</label>Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Queensland Australia</aff><aff id="A4"><label>4</label>Department of Medicine, Norwegian University of Science and Technology, Trondheim, Norway</aff><aff id="A5"><label>5</label>Exercise and Sport Science, University of Utah, Salt Lake City, Utah, USA</aff><aff id="A6"><label>6</label>Department of Radiology and Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, Utah, USA</aff><aff id="A7"><label>7</label>Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 7339, Faculté de Médecine de Marseille, Marseille, France</aff><author-notes><corresp id="FN1"><bold>Corresponding author:</bold> G. Layec, VA Medical Center, Bldg 2, 500 Foothill Dr., Salt Lake City, Utah 84148, USA, <email>gwenael.layec@utah.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>24</day><month>6</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>02</day><month>5</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>8</month><year>2014</year></pub-date><volume>208</volume><issue>4</issue><fpage>376</fpage><lpage>386</lpage><abstract><sec id="S990"><title>Aim</title><p id="P1">Short-term exercise training may induce metabolic and performance adaptations before any changes in mitochondrial enzyme potential. However, there has not been a study that has directly assessed changes in mitochondrial oxidative capacity or metabolic control as a consequence of such training <italic>in vivo</italic>. Therefore, we used <sup>31</sup>P-magnetic resonance spectroscopy (<sup>31</sup>P-MRS) to examine the effect of short-term plantar flexion exercise training on phosphocreatine (PCr) recovery kinetics and the control of respiration rate.</p></sec><sec id="S991"><title>Method</title><p id="P990">To this aim, we investigated 12 healthy men, experienced with this exercise modality (TRA), and 7 time-control subjects (TC).</p></sec><sec id="S992"><title>Results</title><p id="P991">After 5 days of training, maximum work rate during incremental plantar flexion exercise was significantly improved (<italic>P</italic> < 0.01). During the recovery period, the maximal rate of oxidative ATP synthesis (PRE: 28 ± 13 mM.min<sup>−1</sup>; POST: 26 ± 15 mM.min<sup>−1</sup>) and the PCr recovery time constant (PRE: 31 ± 19 s; POST: 29 ± 16) were not significantly altered. In contrast, the Hill coefficient (<italic>n<sub>H</sub></italic>) describing the cooperativity between respiration rate and ADP was significantly increased in TRA (PRE:<italic>n<sub>H</sub></italic> = 2.7 ± 1.4; POST: <italic>n<sub>H</sub></italic> = 3.4 ± 1.9, <italic>P</italic> < 0.05). Meanwhile, there were no systematic variations in any of these variables in TC.</p></sec><sec id="S993"><title>Conclusion</title><p id="P992">This study reveals that 5 days of training induces rapid adaptation in the allosteric control of respiration rate by ADP before any substantial improvement in muscle oxidative capacity occurs.</p></sec></abstract><kwd-group><kwd>skeletal muscle energetics</kwd><kwd>mitochondrial function</kwd><kwd>exercise training</kwd><kwd>metabolic control</kwd><kwd>31P-MRS</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>P01 HL091830 || HL</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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