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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An early inflammatory gene profile in visceral adipose tissue in children</title><author><name sortKey="Tam, Charmaine S" sort="Tam, Charmaine S" uniqKey="Tam C" first="Charmaine S" last="Tam">Charmaine S. Tam</name><affiliation><nlm:aff id="A1">Institute of Endocrinology and Diabetes, The Children’s Hospital at Westmead, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Discipline of Paediatrics and Child Health, The Children’s Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A4">INSERM, U872 (Eq.7), Nutriomique, Paris, France; Université Pierre et Marie Curie- Paris 6, Centre de Recherche des Cordeliers, UMRS 872, 75006, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Heilbronn, Leonie K" sort="Heilbronn, Leonie K" uniqKey="Heilbronn L" first="Leonie K" last="Heilbronn">Leonie K. Heilbronn</name><affiliation><nlm:aff id="A3">Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Australia</nlm:aff></affiliation></author><author><name sortKey="Henegar, Corneliu" sort="Henegar, Corneliu" uniqKey="Henegar C" first="Corneliu" last="Henegar">Corneliu Henegar</name><affiliation><nlm:aff id="A4">INSERM, U872 (Eq.7), Nutriomique, Paris, France; Université Pierre et Marie Curie- Paris 6, Centre de Recherche des Cordeliers, UMRS 872, 75006, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Assistance Publique-Hôpitaux de Paris, Pitie-Salpêtrière Hospital, Nutrition and Endocrinology Department, 75013, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Wong, Melanie" sort="Wong, Melanie" uniqKey="Wong M" first="Melanie" last="Wong">Melanie Wong</name><affiliation><nlm:aff id="A2">Discipline of Paediatrics and Child Health, The Children’s Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</nlm:aff></affiliation></author><author><name sortKey="Cowell, Christopher T" sort="Cowell, Christopher T" uniqKey="Cowell C" first="Christopher T" last="Cowell">Christopher T. Cowell</name><affiliation><nlm:aff id="A1">Institute of Endocrinology and Diabetes, The Children’s Hospital at Westmead, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Discipline of Paediatrics and Child Health, The Children’s Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</nlm:aff></affiliation></author><author><name sortKey="Cowley, Mark J" sort="Cowley, Mark J" uniqKey="Cowley M" first="Mark J" last="Cowley">Mark J. Cowley</name><affiliation><nlm:aff id="A6">Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Australia</nlm:aff></affiliation></author><author><name sortKey="Kaplan, Warren" sort="Kaplan, Warren" uniqKey="Kaplan W" first="Warren" last="Kaplan">Warren Kaplan</name><affiliation><nlm:aff id="A6">Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Australia</nlm:aff></affiliation></author><author><name sortKey="Clement, Karine" sort="Clement, Karine" uniqKey="Clement K" first="Karine" last="Clément">Karine Clément</name><affiliation><nlm:aff id="A4">INSERM, U872 (Eq.7), Nutriomique, Paris, France; Université Pierre et Marie Curie- Paris 6, Centre de Recherche des Cordeliers, UMRS 872, 75006, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Assistance Publique-Hôpitaux de Paris, Pitie-Salpêtrière Hospital, Nutrition and Endocrinology Department, 75013, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Baur, Louise A" sort="Baur, Louise A" uniqKey="Baur L" first="Louise A" last="Baur">Louise A. Baur</name><affiliation><nlm:aff id="A2">Discipline of Paediatrics and Child Health, The Children’s Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21609243</idno><idno type="pmc">4829917</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829917</idno><idno type="RBID">PMC:4829917</idno><idno type="doi">10.3109/17477166.2011.575152</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001E38</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E38</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">An early inflammatory gene profile in visceral adipose tissue in children</title><author><name sortKey="Tam, Charmaine S" sort="Tam, Charmaine S" uniqKey="Tam C" first="Charmaine S" last="Tam">Charmaine S. Tam</name><affiliation><nlm:aff id="A1">Institute of Endocrinology and Diabetes, The Children’s Hospital at Westmead, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Discipline of Paediatrics and Child Health, The Children’s Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A4">INSERM, U872 (Eq.7), Nutriomique, Paris, France; Université Pierre et Marie Curie- Paris 6, Centre de Recherche des Cordeliers, UMRS 872, 75006, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Heilbronn, Leonie K" sort="Heilbronn, Leonie K" uniqKey="Heilbronn L" first="Leonie K" last="Heilbronn">Leonie K. Heilbronn</name><affiliation><nlm:aff id="A3">Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Australia</nlm:aff></affiliation></author><author><name sortKey="Henegar, Corneliu" sort="Henegar, Corneliu" uniqKey="Henegar C" first="Corneliu" last="Henegar">Corneliu Henegar</name><affiliation><nlm:aff id="A4">INSERM, U872 (Eq.7), Nutriomique, Paris, France; Université Pierre et Marie Curie- Paris 6, Centre de Recherche des Cordeliers, UMRS 872, 75006, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Assistance Publique-Hôpitaux de Paris, Pitie-Salpêtrière Hospital, Nutrition and Endocrinology Department, 75013, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Wong, Melanie" sort="Wong, Melanie" uniqKey="Wong M" first="Melanie" last="Wong">Melanie Wong</name><affiliation><nlm:aff id="A2">Discipline of Paediatrics and Child Health, The Children’s Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</nlm:aff></affiliation></author><author><name sortKey="Cowell, Christopher T" sort="Cowell, Christopher T" uniqKey="Cowell C" first="Christopher T" last="Cowell">Christopher T. Cowell</name><affiliation><nlm:aff id="A1">Institute of Endocrinology and Diabetes, The Children’s Hospital at Westmead, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Discipline of Paediatrics and Child Health, The Children’s Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</nlm:aff></affiliation></author><author><name sortKey="Cowley, Mark J" sort="Cowley, Mark J" uniqKey="Cowley M" first="Mark J" last="Cowley">Mark J. Cowley</name><affiliation><nlm:aff id="A6">Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Australia</nlm:aff></affiliation></author><author><name sortKey="Kaplan, Warren" sort="Kaplan, Warren" uniqKey="Kaplan W" first="Warren" last="Kaplan">Warren Kaplan</name><affiliation><nlm:aff id="A6">Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Australia</nlm:aff></affiliation></author><author><name sortKey="Clement, Karine" sort="Clement, Karine" uniqKey="Clement K" first="Karine" last="Clément">Karine Clément</name><affiliation><nlm:aff id="A4">INSERM, U872 (Eq.7), Nutriomique, Paris, France; Université Pierre et Marie Curie- Paris 6, Centre de Recherche des Cordeliers, UMRS 872, 75006, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Assistance Publique-Hôpitaux de Paris, Pitie-Salpêtrière Hospital, Nutrition and Endocrinology Department, 75013, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Baur, Louise A" sort="Baur, Louise A" uniqKey="Baur L" first="Louise A" last="Baur">Louise A. Baur</name><affiliation><nlm:aff id="A2">Discipline of Paediatrics and Child Health, The Children’s Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</nlm:aff></affiliation></author></analytic><series><title level="j">International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity</title><idno type="ISSN">1747-7166</idno><idno type="eISSN">1747-7174</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The aim of this study was to characterise expression profiles of visceral and subcutaneous adipose tissue in children. Adipose tissue samples were collected from children having elective surgery (n=71,54 boys, 6.0±4.3 years). Affymetrix microarrays (n=20) were performed to characterize the functional profile and identify genes of interest in adipose tissue. Visceral adipose tissue had an overrepresentation of Gene Ontology themes related to immune and inflammatory responses and subcutaneous adipose tissue had an overrepresentation of themes related to adipocyte growth and development. Likewise, qPCR performed in the whole cohort showed a 30-fold increase in haptoglobin (P=0.005), 7-fold increase in IL-10 (P<0.001), 8-fold decrease in VEGF (P=0.01) and a 28-fold decrease in TBOX15 (P<0.001) in visceral compared to subcutaneous adipose tissue. The inflammatory pattern in visceral adipose tissue may represent an early stage of the adverse effects of this depot, and combined with chronic obesity, may contribute to increased metabolic and cardiovascular risk.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101256330</journal-id><journal-id journal-id-type="pubmed-jr-id">33508</journal-id><journal-id journal-id-type="nlm-ta">Int J Pediatr Obes</journal-id><journal-id journal-id-type="iso-abbrev">Int J Pediatr Obes</journal-id><journal-title-group><journal-title>International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity</journal-title></journal-title-group><issn pub-type="ppub">1747-7166</issn><issn pub-type="epub">1747-7174</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21609243</article-id><article-id pub-id-type="pmc">4829917</article-id><article-id pub-id-type="doi">10.3109/17477166.2011.575152</article-id><article-id pub-id-type="manuscript">NIHMS775540</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>An early inflammatory gene profile in visceral adipose tissue in children</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tam</surname><given-names>Charmaine S</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Heilbronn</surname><given-names>Leonie K</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Henegar</surname><given-names>Corneliu</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Wong</surname><given-names>Melanie</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Cowell</surname><given-names>Christopher T</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Cowley</surname><given-names>Mark J</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Kaplan</surname><given-names>Warren</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Clément</surname><given-names>Karine</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Baur</surname><given-names>Louise A</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Institute of Endocrinology and Diabetes, The Children’s Hospital at Westmead, Australia</aff><aff id="A2"><label>2</label>Discipline of Paediatrics and Child Health, The Children’s Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</aff><aff id="A3"><label>3</label>Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Australia</aff><aff id="A4"><label>4</label>INSERM, U872 (Eq.7), Nutriomique, Paris, France; Université Pierre et Marie Curie- Paris 6, Centre de Recherche des Cordeliers, UMRS 872, 75006, Paris, France</aff><aff id="A5"><label>5</label>Assistance Publique-Hôpitaux de Paris, Pitie-Salpêtrière Hospital, Nutrition and Endocrinology Department, 75013, Paris, France</aff><aff id="A6"><label>6</label>Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Australia</aff><author-notes><corresp id="FN1">Corresponding Author and Reprint Requests to: Charmaine Tam, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, Phone: 225-763-2778, Fax: 225-763-3030, <email>charmaine.tam@pbrc.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>8</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>24</day><month>5</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>13</day><month>4</month><year>2016</year></pub-date><volume>6</volume><issue>2-2</issue><fpage>e360</fpage><lpage>e363</lpage><pmc-comment>elocation-id from pubmed: 10.3109/17477166.2011.575152</pmc-comment>
<abstract><p id="P1">The aim of this study was to characterise expression profiles of visceral and subcutaneous adipose tissue in children. Adipose tissue samples were collected from children having elective surgery (n=71,54 boys, 6.0±4.3 years). Affymetrix microarrays (n=20) were performed to characterize the functional profile and identify genes of interest in adipose tissue. Visceral adipose tissue had an overrepresentation of Gene Ontology themes related to immune and inflammatory responses and subcutaneous adipose tissue had an overrepresentation of themes related to adipocyte growth and development. Likewise, qPCR performed in the whole cohort showed a 30-fold increase in haptoglobin (P=0.005), 7-fold increase in IL-10 (P<0.001), 8-fold decrease in VEGF (P=0.01) and a 28-fold decrease in TBOX15 (P<0.001) in visceral compared to subcutaneous adipose tissue. The inflammatory pattern in visceral adipose tissue may represent an early stage of the adverse effects of this depot, and combined with chronic obesity, may contribute to increased metabolic and cardiovascular risk.</p></abstract><kwd-group><kwd>inflammation</kwd><kwd>visceral</kwd><kwd>adipose tissue</kwd><kwd>children</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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