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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Queensland study of Melanoma: Environmental and Genetic Associations (Q-MEGA). Study design, baseline characteristics, and repeatability of phenotype and sun exposure measures</title>
<author><name sortKey="Baxter, Amanda J" sort="Baxter, Amanda J" uniqKey="Baxter A" first="Amanda J." last="Baxter">Amanda J. Baxter</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hughes, Maria Celia" sort="Hughes, Maria Celia" uniqKey="Hughes M" first="Maria Celia" last="Hughes">Maria Celia Hughes</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kvaskoff, Marina" sort="Kvaskoff, Marina" uniqKey="Kvaskoff M" first="Marina" last="Kvaskoff">Marina Kvaskoff</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Inserm, (Institut National de la Santé et de la Recherche Médicale), ERI 20, EA 4045, and Institut Gustave Roussy, Villejuif, F-94805 France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Siskind, Victor" sort="Siskind, Victor" uniqKey="Siskind V" first="Victor" last="Siskind">Victor Siskind</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shekar, Sri" sort="Shekar, Sri" uniqKey="Shekar S" first="Sri" last="Shekar">Sri Shekar</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aitken, Joanne F" sort="Aitken, Joanne F" uniqKey="Aitken J" first="Joanne F." last="Aitken">Joanne F. Aitken</name>
<affiliation><nlm:aff id="A3">Viertel Centre for Research in Cancer Control, The Cancer Council Queensland, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Green, Adele C" sort="Green, Adele C" uniqKey="Green A" first="Adele C." last="Green">Adele C. Green</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Duffy, David L" sort="Duffy, David L" uniqKey="Duffy D" first="David L." last="Duffy">David L. Duffy</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18361720</idno>
<idno type="pmc">3677021</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677021</idno>
<idno type="RBID">PMC:3677021</idno>
<idno type="doi">10.1375/twin.11.2.183</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">001E35</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Queensland study of Melanoma: Environmental and Genetic Associations (Q-MEGA). Study design, baseline characteristics, and repeatability of phenotype and sun exposure measures</title>
<author><name sortKey="Baxter, Amanda J" sort="Baxter, Amanda J" uniqKey="Baxter A" first="Amanda J." last="Baxter">Amanda J. Baxter</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hughes, Maria Celia" sort="Hughes, Maria Celia" uniqKey="Hughes M" first="Maria Celia" last="Hughes">Maria Celia Hughes</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kvaskoff, Marina" sort="Kvaskoff, Marina" uniqKey="Kvaskoff M" first="Marina" last="Kvaskoff">Marina Kvaskoff</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Inserm, (Institut National de la Santé et de la Recherche Médicale), ERI 20, EA 4045, and Institut Gustave Roussy, Villejuif, F-94805 France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Siskind, Victor" sort="Siskind, Victor" uniqKey="Siskind V" first="Victor" last="Siskind">Victor Siskind</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shekar, Sri" sort="Shekar, Sri" uniqKey="Shekar S" first="Sri" last="Shekar">Sri Shekar</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aitken, Joanne F" sort="Aitken, Joanne F" uniqKey="Aitken J" first="Joanne F." last="Aitken">Joanne F. Aitken</name>
<affiliation><nlm:aff id="A3">Viertel Centre for Research in Cancer Control, The Cancer Council Queensland, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Green, Adele C" sort="Green, Adele C" uniqKey="Green A" first="Adele C." last="Green">Adele C. Green</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Duffy, David L" sort="Duffy, David L" uniqKey="Duffy D" first="David L." last="Duffy">David L. Duffy</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name>
<affiliation><nlm:aff id="A1">Queensland Institute of Medical Research, Brisbane, QLD, Australia</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Twin research and human genetics : the official journal of the International Society for Twin Studies</title>
<idno type="ISSN">1832-4274</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
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<front><div type="abstract" xml:lang="en"><p id="P1">Cutaneous malignant melanoma (CMM) is a major health issue in Queensland, Australia which has the world’s highest incidence. Recent molecular and epidemiologic studies suggest that CMM arises through multiple etiological pathways involving gene-environment interactions. Understanding the potential mechanisms leading to CMM requires larger studies than those previously conducted. This article describes the design and baseline characteristics of Q-MEGA, the Queensland study of Melanoma: Environmental and Genetic Associations, which followed-up four population-based samples of CMM patients in Queensland, including children, adolescents, men aged over 50, and a large sample of adult cases and their families, including twins. Q-MEGA aims to investigate the roles of genetic and environmental factors, and their interaction, in the etiology of melanoma. 3,471 participants took part in the follow-up study and were administered a computer-assisted telephone interview in 2002–2005. Updated data on environmental and phenotypic risk factors, and 2,777 blood samples were collected from interviewed participants as well as a subset of relatives. This study provides a large and well-described population-based sample of CMM cases with follow-up data. Characteristics of the cases and repeatability of sun exposure and phenotype measures between the baseline and the follow-up surveys, from six to 17 years later, are also described.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101244624</journal-id>
<journal-id journal-id-type="pubmed-jr-id">32375</journal-id>
<journal-id journal-id-type="nlm-ta">Twin Res Hum Genet</journal-id>
<journal-id journal-id-type="iso-abbrev">Twin Res Hum Genet</journal-id>
<journal-title-group><journal-title>Twin research and human genetics : the official journal of the International Society for Twin Studies</journal-title>
</journal-title-group>
<issn pub-type="ppub">1832-4274</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">18361720</article-id>
<article-id pub-id-type="pmc">3677021</article-id>
<article-id pub-id-type="doi">10.1375/twin.11.2.183</article-id>
<article-id pub-id-type="manuscript">NIHMS468849</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>The Queensland study of Melanoma: Environmental and Genetic Associations (Q-MEGA). Study design, baseline characteristics, and repeatability of phenotype and sun exposure measures</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Baxter</surname>
<given-names>Amanda J.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN2" ref-type="author-notes">+</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hughes</surname>
<given-names>Maria Celia</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN2" ref-type="author-notes">+</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kvaskoff</surname>
<given-names>Marina</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref rid="FN2" ref-type="author-notes">+</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Siskind</surname>
<given-names>Victor</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN2" ref-type="author-notes">+</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shekar</surname>
<given-names>Sri</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aitken</surname>
<given-names>Joanne F.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Green</surname>
<given-names>Adele C.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Duffy</surname>
<given-names>David L.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hayward</surname>
<given-names>Nicholas K.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Martin</surname>
<given-names>Nicholas G.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Whiteman</surname>
<given-names>David C.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Queensland Institute of Medical Research, Brisbane, QLD, Australia</aff>
<aff id="A2"><label>2</label>
Inserm, (Institut National de la Santé et de la Recherche Médicale), ERI 20, EA 4045, and Institut Gustave Roussy, Villejuif, F-94805 France</aff>
<aff id="A3"><label>3</label>
Viertel Centre for Research in Cancer Control, The Cancer Council Queensland, Brisbane, QLD, Australia</aff>
<author-notes><corresp id="FN1">Address for correspondence: Dr David Whiteman, Queensland Institute of Medical Research, Cancer and Population Studies Group, CBCRC/B Floor, PO Royal Brisbane Hospital, Queensland 4029, Australia. <email>David.Whiteman@qimr.edu.au</email>
</corresp>
<fn id="FN2" fn-type="equal"><label>+</label>
<p>These authors contributed equally to this paper and were listed in alphabetical order</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>6</day>
<month>5</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><month>4</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>09</day>
<month>6</month>
<year>2013</year>
</pub-date>
<volume>11</volume>
<issue>2</issue>
<fpage>183</fpage>
<lpage>196</lpage>
<abstract><p id="P1">Cutaneous malignant melanoma (CMM) is a major health issue in Queensland, Australia which has the world’s highest incidence. Recent molecular and epidemiologic studies suggest that CMM arises through multiple etiological pathways involving gene-environment interactions. Understanding the potential mechanisms leading to CMM requires larger studies than those previously conducted. This article describes the design and baseline characteristics of Q-MEGA, the Queensland study of Melanoma: Environmental and Genetic Associations, which followed-up four population-based samples of CMM patients in Queensland, including children, adolescents, men aged over 50, and a large sample of adult cases and their families, including twins. Q-MEGA aims to investigate the roles of genetic and environmental factors, and their interaction, in the etiology of melanoma. 3,471 participants took part in the follow-up study and were administered a computer-assisted telephone interview in 2002–2005. Updated data on environmental and phenotypic risk factors, and 2,777 blood samples were collected from interviewed participants as well as a subset of relatives. This study provides a large and well-described population-based sample of CMM cases with follow-up data. Characteristics of the cases and repeatability of sun exposure and phenotype measures between the baseline and the follow-up surveys, from six to 17 years later, are also described.</p>
</abstract>
<funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
<award-id>R01 CA088363 || CA</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>
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