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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Non-Replication of Association for Six Polymorphisms From Meta-Analysis of Genome-Wide Association Studies of Parkinson’s Disease: Large-Scale Collaborative Study</title><author><name sortKey="Evangelou, Evangelos" sort="Evangelou, Evangelos" uniqKey="Evangelou E" first="Evangelos" last="Evangelou">Evangelos Evangelou</name><affiliation><nlm:aff id="A1">Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Institute of Microbiology, University Hospital and University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation><nlm:aff id="A3">Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation><nlm:aff id="A4">Institute of Neurological Sciences, National Research Council, Mangone, Italy</nlm:aff></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation><nlm:aff id="A5">Section of Neurology, Department of Neuroscience, University of Milano-Bicocca San Gerardo Hospital, Monza, Italy</nlm:aff></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation><nlm:aff id="A6">INSERM, UMR_S679, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation><nlm:aff id="A7">INSERM, Unit 708, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">UPMC Univ Paris 06, U708, Neuroepidemiology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation><nlm:aff id="A5">Section of Neurology, Department of Neuroscience, University of Milano-Bicocca San Gerardo Hospital, Monza, Italy</nlm:aff></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation><nlm:aff id="A9">Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff></affiliation></author><author><name sortKey="Krueger, Rejko" sort="Krueger, Rejko" uniqKey="Krueger R" first="Rejko" last="Krueger">Rejko Krueger</name><affiliation><nlm:aff id="A11">Department of Neurology, Hertie Institute for Clinical Brain Research, University Hospital Tuebingen, Tuebingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation><nlm:aff id="A12">INSERM, U744, Institut Pasteur de Lille, Université de Lille 2, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation><nlm:aff id="A6">INSERM, UMR_S679, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Markopoulou, Katerina" sort="Markopoulou, Katerina" uniqKey="Markopoulou K" first="Katerina" last="Markopoulou">Katerina Markopoulou</name><affiliation><nlm:aff id="A9">Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa, Greece</nlm:aff></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation><nlm:aff id="A13">Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD, Australia</nlm:aff></affiliation></author><author><name sortKey="Meeus, Bram" sort="Meeus, Bram" uniqKey="Meeus B" first="Bram" last="Meeus">Bram Meeus</name><affiliation><nlm:aff id="A14">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Laboratory of Neurogenetics, Institute Born-Bunge, Antwerpen, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A16">University of Antwerp, Antwerpen, Belgium</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L." last="Pedersen">Nancy L. Pedersen</name><affiliation><nlm:aff id="A17">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><nlm:aff id="A18">Institute of Neurology, University Magna Graecia, Catanzaro, Italy</nlm:aff></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation><nlm:aff id="A14">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Laboratory of Neurogenetics, Institute Born-Bunge, Antwerpen, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A16">University of Antwerp, Antwerpen, Belgium</nlm:aff></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation><nlm:aff id="A11">Department of Neurology, Hertie Institute for Clinical Brain Research, University Hospital Tuebingen, Tuebingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation><nlm:aff id="A13">Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD, Australia</nlm:aff></affiliation></author><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name><affiliation><nlm:aff id="A19">Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Duke-NUS Graduate Medical School, Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation><nlm:aff id="A17">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation><nlm:aff id="A1">Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19475631</idno><idno type="pmc">4699803</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699803</idno><idno type="RBID">PMC:4699803</idno><idno type="doi">10.1002/ajmg.b.30980</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001E32</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E32</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Non-Replication of Association for Six Polymorphisms From Meta-Analysis of Genome-Wide Association Studies of Parkinson’s Disease: Large-Scale Collaborative Study</title><author><name sortKey="Evangelou, Evangelos" sort="Evangelou, Evangelos" uniqKey="Evangelou E" first="Evangelos" last="Evangelou">Evangelos Evangelou</name><affiliation><nlm:aff id="A1">Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Institute of Microbiology, University Hospital and University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation><nlm:aff id="A3">Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation><nlm:aff id="A4">Institute of Neurological Sciences, National Research Council, Mangone, Italy</nlm:aff></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation><nlm:aff id="A5">Section of Neurology, Department of Neuroscience, University of Milano-Bicocca San Gerardo Hospital, Monza, Italy</nlm:aff></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation><nlm:aff id="A6">INSERM, UMR_S679, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation><nlm:aff id="A7">INSERM, Unit 708, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A8">UPMC Univ Paris 06, U708, Neuroepidemiology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation><nlm:aff id="A5">Section of Neurology, Department of Neuroscience, University of Milano-Bicocca San Gerardo Hospital, Monza, Italy</nlm:aff></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation><nlm:aff id="A9">Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff></affiliation></author><author><name sortKey="Krueger, Rejko" sort="Krueger, Rejko" uniqKey="Krueger R" first="Rejko" last="Krueger">Rejko Krueger</name><affiliation><nlm:aff id="A11">Department of Neurology, Hertie Institute for Clinical Brain Research, University Hospital Tuebingen, Tuebingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation><nlm:aff id="A12">INSERM, U744, Institut Pasteur de Lille, Université de Lille 2, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation><nlm:aff id="A6">INSERM, UMR_S679, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Markopoulou, Katerina" sort="Markopoulou, Katerina" uniqKey="Markopoulou K" first="Katerina" last="Markopoulou">Katerina Markopoulou</name><affiliation><nlm:aff id="A9">Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa, Greece</nlm:aff></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation><nlm:aff id="A13">Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD, Australia</nlm:aff></affiliation></author><author><name sortKey="Meeus, Bram" sort="Meeus, Bram" uniqKey="Meeus B" first="Bram" last="Meeus">Bram Meeus</name><affiliation><nlm:aff id="A14">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Laboratory of Neurogenetics, Institute Born-Bunge, Antwerpen, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A16">University of Antwerp, Antwerpen, Belgium</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L." last="Pedersen">Nancy L. Pedersen</name><affiliation><nlm:aff id="A17">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><nlm:aff id="A18">Institute of Neurology, University Magna Graecia, Catanzaro, Italy</nlm:aff></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation><nlm:aff id="A14">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Laboratory of Neurogenetics, Institute Born-Bunge, Antwerpen, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A16">University of Antwerp, Antwerpen, Belgium</nlm:aff></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation><nlm:aff id="A11">Department of Neurology, Hertie Institute for Clinical Brain Research, University Hospital Tuebingen, Tuebingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation><nlm:aff id="A13">Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD, Australia</nlm:aff></affiliation></author><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name><affiliation><nlm:aff id="A19">Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Duke-NUS Graduate Medical School, Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation><nlm:aff id="A17">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation><nlm:aff id="A1">Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A21">Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts</nlm:aff></affiliation></author></analytic><series><title level="j">American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics</title><idno type="ISSN">1552-4841</idno><idno type="eISSN">1552-485X</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Early genome-wide association (GWA) studies on Parkinson’s disease (PD) have not been able to yield conclusive, replicable signals of association, perhaps due to limited sample size. We aimed to investigate whether association signals derived from the meta-analysis of the first two GWA investigations might be replicable in different populations. We examined six single-nucleotide polymorphisms (SNPs) (rs1000291, rs1865997, rs2241743, rs2282048, rs2313982, and rs3018626) that had reached nominal significance with at least two of three different strategies proposed in a previous analysis of the original GWA studies. Investigators from the “Genetic Epidemiology of Parkinson’s Disease” (GEOPD) consortium were invited to join in this study. Ten teams contributed replication data from 3,458 PD cases and 3,719 controls. The data from the two previously published GWAs (599 PD cases, 592 controls and 443 sibling pairs) were considered as well. All data were synthesized using both fixed and random effects models. The summary allelic odds ratios were ranging from 0.97 to 1.09 by random effects, when all data were included. The summary estimates of the replication data sets (excluding the original GWA data) were very close to 1.00 (range 0.98–1.09) and none of the effects were nominally statistically significant. The replication data sets had significantly different results than the GWA data. Our data do not support evidence that any of these six SNPs reflect susceptibility markers for PD. Much stronger signals of statistical significance in GWA platforms are needed to have substantial chances of replication. Specifically in PD genetics, this would require much larger GWA studies and perhaps novel analytical techniques.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101235742</journal-id><journal-id journal-id-type="pubmed-jr-id">32212</journal-id><journal-id journal-id-type="nlm-ta">Am J Med Genet B Neuropsychiatr Genet</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Med. Genet. B Neuropsychiatr. Genet.</journal-id><journal-title-group><journal-title>American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics</journal-title></journal-title-group><issn pub-type="ppub">1552-4841</issn><issn pub-type="epub">1552-485X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19475631</article-id><article-id pub-id-type="pmc">4699803</article-id><article-id pub-id-type="doi">10.1002/ajmg.b.30980</article-id><article-id pub-id-type="manuscript">NIHMS746471</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Non-Replication of Association for Six Polymorphisms From Meta-Analysis of Genome-Wide Association Studies of Parkinson’s Disease: Large-Scale Collaborative Study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Evangelou</surname><given-names>Evangelos</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Maraganore</surname><given-names>Demetrius M.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Annesi</surname><given-names>Grazia</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Brighina</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Brice</surname><given-names>Alexis</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Elbaz</surname><given-names>Alexis</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Ferrarese</surname><given-names>Carlo</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Hadjigeorgiou</surname><given-names>Georgios M.</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Krueger</surname><given-names>Rejko</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Lambert</surname><given-names>Jean-Charles</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Lesage</surname><given-names>Suzanne</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Markopoulou</surname><given-names>Katerina</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Mellick</surname><given-names>George D.</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Meeus</surname><given-names>Bram</given-names></name><xref ref-type="aff" rid="A14">14</xref><xref ref-type="aff" rid="A15">15</xref><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Pedersen</surname><given-names>Nancy L.</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Quattrone</surname><given-names>Aldo</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Van Broeckhoven</surname><given-names>Christine</given-names></name><xref ref-type="aff" rid="A14">14</xref><xref ref-type="aff" rid="A15">15</xref><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Sharma</surname><given-names>Manu</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Silburn</surname><given-names>Peter A.</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Eng-King</given-names></name><xref ref-type="aff" rid="A19">19</xref><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Wirdefeldt</surname><given-names>Karin</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Ioannidis</surname><given-names>John P.A.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A21">21</xref><xref ref-type="aff" rid="A22">22</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><on-behalf-of>for the Genetic Epidemiology of Parkinson’s Disease (GEOPD) Consortium</on-behalf-of></contrib-group><aff id="A1"><label>1</label>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</aff><aff id="A2"><label>2</label>Institute of Microbiology, University Hospital and University of Lausanne, Lausanne, Switzerland</aff><aff id="A3"><label>3</label>Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota</aff><aff id="A4"><label>4</label>Institute of Neurological Sciences, National Research Council, Mangone, Italy</aff><aff id="A5"><label>5</label>Section of Neurology, Department of Neuroscience, University of Milano-Bicocca San Gerardo Hospital, Monza, Italy</aff><aff id="A6"><label>6</label>INSERM, UMR_S679, Paris, France</aff><aff id="A7"><label>7</label>INSERM, Unit 708, Paris, France</aff><aff id="A8"><label>8</label>UPMC Univ Paris 06, U708, Neuroepidemiology, Paris, France</aff><aff id="A9"><label>9</label>Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa, Greece</aff><aff id="A10"><label>10</label>Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</aff><aff id="A11"><label>11</label>Department of Neurology, Hertie Institute for Clinical Brain Research, University Hospital Tuebingen, Tuebingen, Germany</aff><aff id="A12"><label>12</label>INSERM, U744, Institut Pasteur de Lille, Université de Lille 2, Lille, France</aff><aff id="A13"><label>13</label>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD, Australia</aff><aff id="A14"><label>14</label>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium</aff><aff id="A15"><label>15</label>Laboratory of Neurogenetics, Institute Born-Bunge, Antwerpen, Belgium</aff><aff id="A16"><label>16</label>University of Antwerp, Antwerpen, Belgium</aff><aff id="A17"><label>17</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A18"><label>18</label>Institute of Neurology, University Magna Graecia, Catanzaro, Italy</aff><aff id="A19"><label>19</label>Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore</aff><aff id="A20"><label>20</label>Duke-NUS Graduate Medical School, Singapore, Singapore</aff><aff id="A21"><label>21</label>Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece</aff><aff id="A22"><label>22</label>Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts</aff><author-notes><corresp id="FN1"><label>*</label>Correspondence to: John P.A. Ioannidis, Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece. <email>jioannid@cc.uoi.gr</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>23</day><month>12</month><year>2015</year></pub-date><pub-date pub-type="ppub"><day>5</day><month>1</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>04</day><month>1</month><year>2016</year></pub-date><volume>0</volume><issue>1</issue><fpage>220</fpage><lpage>228</lpage><pmc-comment>elocation-id from pubmed: 10.1002/ajmg.b.30980</pmc-comment>
<abstract><p id="P1">Early genome-wide association (GWA) studies on Parkinson’s disease (PD) have not been able to yield conclusive, replicable signals of association, perhaps due to limited sample size. We aimed to investigate whether association signals derived from the meta-analysis of the first two GWA investigations might be replicable in different populations. We examined six single-nucleotide polymorphisms (SNPs) (rs1000291, rs1865997, rs2241743, rs2282048, rs2313982, and rs3018626) that had reached nominal significance with at least two of three different strategies proposed in a previous analysis of the original GWA studies. Investigators from the “Genetic Epidemiology of Parkinson’s Disease” (GEOPD) consortium were invited to join in this study. Ten teams contributed replication data from 3,458 PD cases and 3,719 controls. The data from the two previously published GWAs (599 PD cases, 592 controls and 443 sibling pairs) were considered as well. All data were synthesized using both fixed and random effects models. The summary allelic odds ratios were ranging from 0.97 to 1.09 by random effects, when all data were included. The summary estimates of the replication data sets (excluding the original GWA data) were very close to 1.00 (range 0.98–1.09) and none of the effects were nominally statistically significant. The replication data sets had significantly different results than the GWA data. Our data do not support evidence that any of these six SNPs reflect susceptibility markers for PD. Much stronger signals of statistical significance in GWA platforms are needed to have substantial chances of replication. Specifically in PD genetics, this would require much larger GWA studies and perhaps novel analytical techniques.</p></abstract><kwd-group><kwd>Parkinson’s disease</kwd><kwd>meta-analysis</kwd><kwd>genome-wide association</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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