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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer’s disease research</title><author><name sortKey="O Ryant, Sid E" sort="O Ryant, Sid E" uniqKey="O Ryant S" first="Sid E." last="O Ryant">Sid E. O Ryant</name><affiliation><nlm:aff id="A1">Institute for Aging & Alzheimer’s Disease Research and Department of Internal Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Gupta, Veer" sort="Gupta, Veer" uniqKey="Gupta V" first="Veer" last="Gupta">Veer Gupta</name><affiliation><nlm:aff id="A2">Centre of Excellence for Alzheimer’s Disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia</nlm:aff></affiliation></author><author><name sortKey="Henriksen, Kim" sort="Henriksen, Kim" uniqKey="Henriksen K" first="Kim" last="Henriksen">Kim Henriksen</name><affiliation><nlm:aff id="A3">Nordic Bioscience Biomarkers and Research, Neurodegenerative Diseases, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Edwards, Melissa" sort="Edwards, Melissa" uniqKey="Edwards M" first="Melissa" last="Edwards">Melissa Edwards</name><affiliation><nlm:aff id="A4">Department of Psychology, University of North Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Jeromin, Andreas" sort="Jeromin, Andreas" uniqKey="Jeromin A" first="Andreas" last="Jeromin">Andreas Jeromin</name><affiliation><nlm:aff id="A5">Atlantic Biomarkers, LLC, Gainesville, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Lista, Simone" sort="Lista, Simone" uniqKey="Lista S" first="Simone" last="Lista">Simone Lista</name><affiliation><nlm:aff id="A6">AXA Research Fund & UPMC Chair</nlm:aff></affiliation></author><author><name sortKey="Bazenet, Chantal" sort="Bazenet, Chantal" uniqKey="Bazenet C" first="Chantal" last="Bazenet">Chantal Bazenet</name><affiliation><nlm:aff id="A7">King’s College London, Department of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London, UK</nlm:aff></affiliation></author><author><name sortKey="Soares, Holly" sort="Soares, Holly" uniqKey="Soares H" first="Holly" last="Soares">Holly Soares</name><affiliation><nlm:aff id="A8">Bristol-Myers Squibb, Wallingford, CT, USA</nlm:aff></affiliation></author><author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><affiliation><nlm:aff id="A7">King’s College London, Department of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London, UK</nlm:aff></affiliation></author><author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><affiliation><nlm:aff id="A6">AXA Research Fund & UPMC Chair</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d’Alzheimer & Institut du Cerveau et de la Moelle épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpétrière, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Montine, Thomas" sort="Montine, Thomas" uniqKey="Montine T" first="Thomas" last="Montine">Thomas Montine</name><affiliation><nlm:aff id="A10">Department of Pathology, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Blennow, Kaj" sort="Blennow, Kaj" uniqKey="Blennow K" first="Kaj" last="Blennow">Kaj Blennow</name><affiliation><nlm:aff id="A11">Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, Molndal, Sweden</nlm:aff></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation><nlm:aff id="A12">Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Carrillo, Maria" sort="Carrillo, Maria" uniqKey="Carrillo M" first="Maria" last="Carrillo">Maria Carrillo</name><affiliation><nlm:aff id="A13">Alzheimer’s Association, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Graff Radford, Neill" sort="Graff Radford, Neill" uniqKey="Graff Radford N" first="Neill" last="Graff-Radford">Neill Graff-Radford</name><affiliation><nlm:aff id="A14">Department of Neurology, Mayo Clinic Jacksonville, Jacksonville, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Laske, Christoph" sort="Laske, Christoph" uniqKey="Laske C" first="Christoph" last="Laske">Christoph Laske</name><affiliation><nlm:aff id="A15">Section for Dementia Research, Hertie-Institute of Clinical Brain Research, University of Tübingen, Tübingen, Germany & German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Breteler, Monique" sort="Breteler, Monique" uniqKey="Breteler M" first="Monique" last="Breteler">Monique Breteler</name><affiliation><nlm:aff id="A16">Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany & German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Shaw, Leslie" sort="Shaw, Leslie" uniqKey="Shaw L" first="Leslie" last="Shaw">Leslie Shaw</name><affiliation><nlm:aff id="A17">Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q." last="Trojanowski">John Q. Trojanowski</name><affiliation><nlm:aff id="A17">Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Schupf, Nicole" sort="Schupf, Nicole" uniqKey="Schupf N" first="Nicole" last="Schupf">Nicole Schupf</name><affiliation><nlm:aff id="A18">Department of Epidemiology, Joseph P Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Rissman, Robert A" sort="Rissman, Robert A" uniqKey="Rissman R" first="Robert A." last="Rissman">Robert A. Rissman</name><affiliation><nlm:aff id="A19">Alzheimer’s Disease Cooperative Study, Department of Neurosciences, UCSD School of Medicine, La Jolla, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Fagan, Anne M" sort="Fagan, Anne M" uniqKey="Fagan A" first="Anne M." last="Fagan">Anne M. Fagan</name><affiliation><nlm:aff id="A20">Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff></affiliation></author><author><name sortKey="Oberoi, Pankaj" sort="Oberoi, Pankaj" uniqKey="Oberoi P" first="Pankaj" last="Oberoi">Pankaj Oberoi</name><affiliation><nlm:aff id="A21">Meso Scale Discovery, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Umek, Robert" sort="Umek, Robert" uniqKey="Umek R" first="Robert" last="Umek">Robert Umek</name><affiliation><nlm:aff id="A21">Meso Scale Discovery, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Weiner, Michael W" sort="Weiner, Michael W" uniqKey="Weiner M" first="Michael W." last="Weiner">Michael W. Weiner</name><affiliation><nlm:aff id="A22">Department of Medicine, Radiology and Psychiatry, University of California, San Francisco, San Francisco, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Grammas, Paula" sort="Grammas, Paula" uniqKey="Grammas P" first="Paula" last="Grammas">Paula Grammas</name><affiliation><nlm:aff id="A23">Texas Tech University Health Science Center, Garrison Institute on Aging, Lubbock, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Posner, Holly" sort="Posner, Holly" uniqKey="Posner H" first="Holly" last="Posner">Holly Posner</name><affiliation><nlm:aff id="A24">Pfizer Inc., New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Martins, Ralph" sort="Martins, Ralph" uniqKey="Martins R" first="Ralph" last="Martins">Ralph Martins</name><affiliation><nlm:aff id="A2">Centre of Excellence for Alzheimer’s Disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25282381</idno><idno type="pmc">4414664</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414664</idno><idno type="RBID">PMC:4414664</idno><idno type="doi">10.1016/j.jalz.2014.08.099</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001E25</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E25</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer’s disease research</title><author><name sortKey="O Ryant, Sid E" sort="O Ryant, Sid E" uniqKey="O Ryant S" first="Sid E." last="O Ryant">Sid E. O Ryant</name><affiliation><nlm:aff id="A1">Institute for Aging & Alzheimer’s Disease Research and Department of Internal Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Gupta, Veer" sort="Gupta, Veer" uniqKey="Gupta V" first="Veer" last="Gupta">Veer Gupta</name><affiliation><nlm:aff id="A2">Centre of Excellence for Alzheimer’s Disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia</nlm:aff></affiliation></author><author><name sortKey="Henriksen, Kim" sort="Henriksen, Kim" uniqKey="Henriksen K" first="Kim" last="Henriksen">Kim Henriksen</name><affiliation><nlm:aff id="A3">Nordic Bioscience Biomarkers and Research, Neurodegenerative Diseases, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Edwards, Melissa" sort="Edwards, Melissa" uniqKey="Edwards M" first="Melissa" last="Edwards">Melissa Edwards</name><affiliation><nlm:aff id="A4">Department of Psychology, University of North Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Jeromin, Andreas" sort="Jeromin, Andreas" uniqKey="Jeromin A" first="Andreas" last="Jeromin">Andreas Jeromin</name><affiliation><nlm:aff id="A5">Atlantic Biomarkers, LLC, Gainesville, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Lista, Simone" sort="Lista, Simone" uniqKey="Lista S" first="Simone" last="Lista">Simone Lista</name><affiliation><nlm:aff id="A6">AXA Research Fund & UPMC Chair</nlm:aff></affiliation></author><author><name sortKey="Bazenet, Chantal" sort="Bazenet, Chantal" uniqKey="Bazenet C" first="Chantal" last="Bazenet">Chantal Bazenet</name><affiliation><nlm:aff id="A7">King’s College London, Department of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London, UK</nlm:aff></affiliation></author><author><name sortKey="Soares, Holly" sort="Soares, Holly" uniqKey="Soares H" first="Holly" last="Soares">Holly Soares</name><affiliation><nlm:aff id="A8">Bristol-Myers Squibb, Wallingford, CT, USA</nlm:aff></affiliation></author><author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><affiliation><nlm:aff id="A7">King’s College London, Department of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London, UK</nlm:aff></affiliation></author><author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><affiliation><nlm:aff id="A6">AXA Research Fund & UPMC Chair</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d’Alzheimer & Institut du Cerveau et de la Moelle épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpétrière, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Montine, Thomas" sort="Montine, Thomas" uniqKey="Montine T" first="Thomas" last="Montine">Thomas Montine</name><affiliation><nlm:aff id="A10">Department of Pathology, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Blennow, Kaj" sort="Blennow, Kaj" uniqKey="Blennow K" first="Kaj" last="Blennow">Kaj Blennow</name><affiliation><nlm:aff id="A11">Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, Molndal, Sweden</nlm:aff></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation><nlm:aff id="A12">Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Carrillo, Maria" sort="Carrillo, Maria" uniqKey="Carrillo M" first="Maria" last="Carrillo">Maria Carrillo</name><affiliation><nlm:aff id="A13">Alzheimer’s Association, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Graff Radford, Neill" sort="Graff Radford, Neill" uniqKey="Graff Radford N" first="Neill" last="Graff-Radford">Neill Graff-Radford</name><affiliation><nlm:aff id="A14">Department of Neurology, Mayo Clinic Jacksonville, Jacksonville, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Laske, Christoph" sort="Laske, Christoph" uniqKey="Laske C" first="Christoph" last="Laske">Christoph Laske</name><affiliation><nlm:aff id="A15">Section for Dementia Research, Hertie-Institute of Clinical Brain Research, University of Tübingen, Tübingen, Germany & German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Breteler, Monique" sort="Breteler, Monique" uniqKey="Breteler M" first="Monique" last="Breteler">Monique Breteler</name><affiliation><nlm:aff id="A16">Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany & German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Shaw, Leslie" sort="Shaw, Leslie" uniqKey="Shaw L" first="Leslie" last="Shaw">Leslie Shaw</name><affiliation><nlm:aff id="A17">Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q." last="Trojanowski">John Q. Trojanowski</name><affiliation><nlm:aff id="A17">Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA, USA</nlm:aff></affiliation></author><author><name sortKey="Schupf, Nicole" sort="Schupf, Nicole" uniqKey="Schupf N" first="Nicole" last="Schupf">Nicole Schupf</name><affiliation><nlm:aff id="A18">Department of Epidemiology, Joseph P Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Rissman, Robert A" sort="Rissman, Robert A" uniqKey="Rissman R" first="Robert A." last="Rissman">Robert A. Rissman</name><affiliation><nlm:aff id="A19">Alzheimer’s Disease Cooperative Study, Department of Neurosciences, UCSD School of Medicine, La Jolla, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Fagan, Anne M" sort="Fagan, Anne M" uniqKey="Fagan A" first="Anne M." last="Fagan">Anne M. Fagan</name><affiliation><nlm:aff id="A20">Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff></affiliation></author><author><name sortKey="Oberoi, Pankaj" sort="Oberoi, Pankaj" uniqKey="Oberoi P" first="Pankaj" last="Oberoi">Pankaj Oberoi</name><affiliation><nlm:aff id="A21">Meso Scale Discovery, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Umek, Robert" sort="Umek, Robert" uniqKey="Umek R" first="Robert" last="Umek">Robert Umek</name><affiliation><nlm:aff id="A21">Meso Scale Discovery, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Weiner, Michael W" sort="Weiner, Michael W" uniqKey="Weiner M" first="Michael W." last="Weiner">Michael W. Weiner</name><affiliation><nlm:aff id="A22">Department of Medicine, Radiology and Psychiatry, University of California, San Francisco, San Francisco, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Grammas, Paula" sort="Grammas, Paula" uniqKey="Grammas P" first="Paula" last="Grammas">Paula Grammas</name><affiliation><nlm:aff id="A23">Texas Tech University Health Science Center, Garrison Institute on Aging, Lubbock, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Posner, Holly" sort="Posner, Holly" uniqKey="Posner H" first="Holly" last="Posner">Holly Posner</name><affiliation><nlm:aff id="A24">Pfizer Inc., New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Martins, Ralph" sort="Martins, Ralph" uniqKey="Martins R" first="Ralph" last="Martins">Ralph Martins</name><affiliation><nlm:aff id="A2">Centre of Excellence for Alzheimer’s Disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia</nlm:aff></affiliation></author></analytic><series><title level="j">Alzheimer's & dementia : the journal of the Alzheimer's Association</title><idno type="ISSN">1552-5260</idno><idno type="eISSN">1552-5279</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The lack of readily available biomarkers is a significant hindrance towards progressing to effective therapeutic and preventative strategies for Alzheimer’s disease (AD). Blood-based biomarkers have potential to overcome access and cost barriers and greatly facilitate advanced neuroimaging and cerebrospinal fluid biomarker approaches. Despite the fact that preanalytical processing is the largest source of variability in laboratory testing, there are no currently available standardized preanalytical guidelines. The current international working group provides the initial starting point for such guidelines for standardized operating procedures (SOPs). It is anticipated that these guidelines will be updated as additional research findings become available. The statement provides (1) a synopsis of selected preanalytical methods utilized in many international AD cohort studies, (2) initial draft guidelines/SOPs for preanalytical methods, and (3) a list of required methodological information and protocols to be made available for publications in the field in order to foster cross-validation across cohorts and laboratories.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101231978</journal-id><journal-id journal-id-type="pubmed-jr-id">33173</journal-id><journal-id journal-id-type="nlm-ta">Alzheimers Dement</journal-id><journal-id journal-id-type="iso-abbrev">Alzheimers Dement</journal-id><journal-title-group><journal-title>Alzheimer's & dementia : the journal of the Alzheimer's Association</journal-title></journal-title-group><issn pub-type="ppub">1552-5260</issn><issn pub-type="epub">1552-5279</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25282381</article-id><article-id pub-id-type="pmc">4414664</article-id><article-id pub-id-type="doi">10.1016/j.jalz.2014.08.099</article-id><article-id pub-id-type="manuscript">NIHMS631858</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer’s disease research</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>O’Bryant</surname><given-names>Sid E.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Gupta</surname><given-names>Veer</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Henriksen</surname><given-names>Kim</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Edwards</surname><given-names>Melissa</given-names></name><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Jeromin</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Lista</surname><given-names>Simone</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Bazenet</surname><given-names>Chantal</given-names></name><xref ref-type="aff" rid="A7">g</xref></contrib><contrib contrib-type="author"><name><surname>Soares</surname><given-names>Holly</given-names></name><xref ref-type="aff" rid="A8">h</xref></contrib><contrib contrib-type="author"><name><surname>Lovestone</surname><given-names>Simon</given-names></name><xref ref-type="aff" rid="A7">g</xref></contrib><contrib contrib-type="author"><name><surname>Hampel</surname><given-names>Harald</given-names></name><xref ref-type="aff" rid="A6">f</xref><xref ref-type="aff" rid="A9">i</xref></contrib><contrib contrib-type="author"><name><surname>Montine</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="A10">j</xref></contrib><contrib contrib-type="author"><name><surname>Blennow</surname><given-names>Kaj</given-names></name><xref ref-type="aff" rid="A11">k</xref></contrib><contrib contrib-type="author"><name><surname>Foroud</surname><given-names>Tatiana</given-names></name><xref ref-type="aff" rid="A12">l</xref></contrib><contrib contrib-type="author"><name><surname>Carrillo</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="A13">m</xref></contrib><contrib contrib-type="author"><name><surname>Graff-Radford</surname><given-names>Neill</given-names></name><xref ref-type="aff" rid="A14">n</xref></contrib><contrib contrib-type="author"><name><surname>Laske</surname><given-names>Christoph</given-names></name><xref ref-type="aff" rid="A15">o</xref></contrib><contrib contrib-type="author"><name><surname>Breteler</surname><given-names>Monique</given-names></name><xref ref-type="aff" rid="A16">p</xref></contrib><contrib contrib-type="author"><name><surname>Shaw</surname><given-names>Leslie</given-names></name><xref ref-type="aff" rid="A17">q</xref></contrib><contrib contrib-type="author"><name><surname>Trojanowski</surname><given-names>John Q.</given-names></name><xref ref-type="aff" rid="A17">q</xref></contrib><contrib contrib-type="author"><name><surname>Schupf</surname><given-names>Nicole</given-names></name><xref ref-type="aff" rid="A18">r</xref></contrib><contrib contrib-type="author"><name><surname>Rissman</surname><given-names>Robert A.</given-names></name><xref ref-type="aff" rid="A19">s</xref></contrib><contrib contrib-type="author"><name><surname>Fagan</surname><given-names>Anne M.</given-names></name><xref ref-type="aff" rid="A20">t</xref></contrib><contrib contrib-type="author"><name><surname>Oberoi</surname><given-names>Pankaj</given-names></name><xref ref-type="aff" rid="A21">u</xref></contrib><contrib contrib-type="author"><name><surname>Umek</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="A21">u</xref></contrib><contrib contrib-type="author"><name><surname>Weiner</surname><given-names>Michael W.</given-names></name><xref ref-type="aff" rid="A22">v</xref></contrib><contrib contrib-type="author"><name><surname>Grammas</surname><given-names>Paula</given-names></name><xref ref-type="aff" rid="A23">w</xref></contrib><contrib contrib-type="author"><name><surname>Posner</surname><given-names>Holly</given-names></name><xref ref-type="aff" rid="A24">x</xref></contrib><contrib contrib-type="author"><name><surname>Martins</surname><given-names>Ralph</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><collab>for the for the STAR-B and BBBIG working groups<xref ref-type="app" rid="APP1">†</xref></collab></contrib></contrib-group><aff id="A1"><label>a</label>Institute for Aging & Alzheimer’s Disease Research and Department of Internal Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA</aff><aff id="A2"><label>b</label>Centre of Excellence for Alzheimer’s Disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia</aff><aff id="A3"><label>c</label>Nordic Bioscience Biomarkers and Research, Neurodegenerative Diseases, Herlev, Denmark</aff><aff id="A4"><label>d</label>Department of Psychology, University of North Texas, USA</aff><aff id="A5"><label>e</label>Atlantic Biomarkers, LLC, Gainesville, FL, USA</aff><aff id="A6"><label>f</label>AXA Research Fund & UPMC Chair</aff><aff id="A7"><label>g</label>King’s College London, Department of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London, UK</aff><aff id="A8"><label>h</label>Bristol-Myers Squibb, Wallingford, CT, USA</aff><aff id="A9"><label>i</label>Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d’Alzheimer & Institut du Cerveau et de la Moelle épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpétrière, Paris, France</aff><aff id="A10"><label>j</label>Department of Pathology, University of Washington, Seattle, WA, USA</aff><aff id="A11"><label>k</label>Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, Molndal, Sweden</aff><aff id="A12"><label>l</label>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA</aff><aff id="A13"><label>m</label>Alzheimer’s Association, Chicago, IL, USA</aff><aff id="A14"><label>n</label>Department of Neurology, Mayo Clinic Jacksonville, Jacksonville, FL, USA</aff><aff id="A15"><label>o</label>Section for Dementia Research, Hertie-Institute of Clinical Brain Research, University of Tübingen, Tübingen, Germany & German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</aff><aff id="A16"><label>p</label>Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany & German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</aff><aff id="A17"><label>q</label>Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA, USA</aff><aff id="A18"><label>r</label>Department of Epidemiology, Joseph P Mailman School of Public Health, Columbia University, New York, NY, USA</aff><aff id="A19"><label>s</label>Alzheimer’s Disease Cooperative Study, Department of Neurosciences, UCSD School of Medicine, La Jolla, CA, USA</aff><aff id="A20"><label>t</label>Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA</aff><aff id="A21"><label>u</label>Meso Scale Discovery, Rockville, MD, USA</aff><aff id="A22"><label>v</label>Department of Medicine, Radiology and Psychiatry, University of California, San Francisco, San Francisco, CA, USA</aff><aff id="A23"><label>w</label>Texas Tech University Health Science Center, Garrison Institute on Aging, Lubbock, TX, USA</aff><aff id="A24"><label>x</label>Pfizer Inc., New York, NY, USA</aff><pub-date pub-type="nihms-submitted"><day>21</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>1</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2016</year></pub-date><volume>11</volume><issue>5</issue><fpage>549</fpage><lpage>560</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.jalz.2014.08.099</pmc-comment>
<permissions><copyright-statement>© 2014 The Authors. Published by The Alzheimer’s Association</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p id="P1">The lack of readily available biomarkers is a significant hindrance towards progressing to effective therapeutic and preventative strategies for Alzheimer’s disease (AD). Blood-based biomarkers have potential to overcome access and cost barriers and greatly facilitate advanced neuroimaging and cerebrospinal fluid biomarker approaches. Despite the fact that preanalytical processing is the largest source of variability in laboratory testing, there are no currently available standardized preanalytical guidelines. The current international working group provides the initial starting point for such guidelines for standardized operating procedures (SOPs). It is anticipated that these guidelines will be updated as additional research findings become available. The statement provides (1) a synopsis of selected preanalytical methods utilized in many international AD cohort studies, (2) initial draft guidelines/SOPs for preanalytical methods, and (3) a list of required methodological information and protocols to be made available for publications in the field in order to foster cross-validation across cohorts and laboratories.</p></abstract><kwd-group><kwd>Biomarkers</kwd><kwd>blood</kwd><kwd>serum</kwd><kwd>plasma</kwd><kwd>Alzheimer’s disease</kwd><kwd>dementia</kwd><kwd>diagnosis</kwd><kwd>treatment</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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