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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type 2 diabetes: a prospective cohort study from ADVANCE</title><author><name sortKey="Czernichow, Sebastien" sort="Czernichow, Sebastien" uniqKey="Czernichow S" first="Sébastien" last="Czernichow">Sébastien Czernichow</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Public Health, Avicenne Hospital; University of Paris 13, France</nlm:aff></affiliation></author><author><name sortKey="Kengne, Andre Pascal" sort="Kengne, Andre Pascal" uniqKey="Kengne A" first="Andre-Pascal" last="Kengne">Andre-Pascal Kengne</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Huxley, Rachel R" sort="Huxley, Rachel R" uniqKey="Huxley R" first="Rachel R." last="Huxley">Rachel R. Huxley</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Batty, G David" sort="Batty, G David" uniqKey="Batty G" first="G David" last="Batty">G David Batty</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Medical Research Council Social & Public Health Sciences Unit, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="De Galan, Bastiaan" sort="De Galan, Bastiaan" uniqKey="De Galan B" first="Bastiaan" last="De Galan">Bastiaan De Galan</name><affiliation><nlm:aff id="A4">Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Grobbee, Diederick" sort="Grobbee, Diederick" uniqKey="Grobbee D" first="Diederick" last="Grobbee">Diederick Grobbee</name><affiliation><nlm:aff id="A5">Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pillai, Avinesh" sort="Pillai, Avinesh" uniqKey="Pillai A" first="Avinesh" last="Pillai">Avinesh Pillai</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Zoungas, Sophia" sort="Zoungas, Sophia" uniqKey="Zoungas S" first="Sophia" last="Zoungas">Sophia Zoungas</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Monash University, Melbourne, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Marre, Michel" sort="Marre, Michel" uniqKey="Marre M" first="Michel" last="Marre">Michel Marre</name><affiliation><nlm:aff id="A7">Endocrinologie, Diabétologie & Nutrition, Hôpital Bichat-Claude Bernard, France</nlm:aff></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Neal, Bruce" sort="Neal, Bruce" uniqKey="Neal B" first="Bruce" last="Neal">Bruce Neal</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20628304</idno><idno type="pmc">4170784</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170784</idno><idno type="RBID">PMC:4170784</idno><idno type="doi">10.1097/HJR.0b013e32833c1aa3</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001E21</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E21</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type 2 diabetes: a prospective cohort study from ADVANCE</title><author><name sortKey="Czernichow, Sebastien" sort="Czernichow, Sebastien" uniqKey="Czernichow S" first="Sébastien" last="Czernichow">Sébastien Czernichow</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Public Health, Avicenne Hospital; University of Paris 13, France</nlm:aff></affiliation></author><author><name sortKey="Kengne, Andre Pascal" sort="Kengne, Andre Pascal" uniqKey="Kengne A" first="Andre-Pascal" last="Kengne">Andre-Pascal Kengne</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Huxley, Rachel R" sort="Huxley, Rachel R" uniqKey="Huxley R" first="Rachel R." last="Huxley">Rachel R. Huxley</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Batty, G David" sort="Batty, G David" uniqKey="Batty G" first="G David" last="Batty">G David Batty</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Medical Research Council Social & Public Health Sciences Unit, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="De Galan, Bastiaan" sort="De Galan, Bastiaan" uniqKey="De Galan B" first="Bastiaan" last="De Galan">Bastiaan De Galan</name><affiliation><nlm:aff id="A4">Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Grobbee, Diederick" sort="Grobbee, Diederick" uniqKey="Grobbee D" first="Diederick" last="Grobbee">Diederick Grobbee</name><affiliation><nlm:aff id="A5">Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pillai, Avinesh" sort="Pillai, Avinesh" uniqKey="Pillai A" first="Avinesh" last="Pillai">Avinesh Pillai</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Zoungas, Sophia" sort="Zoungas, Sophia" uniqKey="Zoungas S" first="Sophia" last="Zoungas">Sophia Zoungas</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Monash University, Melbourne, VIC, Australia</nlm:aff></affiliation></author><author><name sortKey="Marre, Michel" sort="Marre, Michel" uniqKey="Marre M" first="Michel" last="Marre">Michel Marre</name><affiliation><nlm:aff id="A7">Endocrinologie, Diabétologie & Nutrition, Hôpital Bichat-Claude Bernard, France</nlm:aff></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Neal, Bruce" sort="Neal, Bruce" uniqKey="Neal B" first="Bruce" last="Neal">Bruce Neal</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><affiliation><nlm:aff id="A1">The George Institute for International Health; The University of Sydney, Australia</nlm:aff></affiliation></author></analytic><series><title level="j">European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology</title><idno type="ISSN">1741-8267</idno><idno type="eISSN">1741-8275</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Aims</title><p id="P1">The aim of this study was to compare the strength of associations and discrimination capability of body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) with cardiovascular disease risk in individuals with type-2-diabetes.</p></sec><sec id="S2"><title>Methods and results</title><p id="P2">11,140 men and women were followed for a mean of 4.8 years. Cox proportional hazard models were used to compute the hazard ratios (HR) and 95% confidence intervals (95% CI) for one standard deviation (SD) increase in baseline BMI (SD: 5 kg/m<sup>2</sup>), WC (SD: 13 cm) and WHR (SD: 0.08) with cardiovascular disease risk. After adjustment, HR (95% CI) for WC were 1.10 (1.03-1.18) for cardiovascular events, 1.13 (1.03-1.24) for coronary events, and 1.08 (0.98-1.19) for cardiovascular deaths. Estimates for WHR were 1.12 (1.05-1.19), 1.17 (1.08-1.28) and 1.19 (1.09-1.31). BMI was not related to any of these outcomes. While the receiver operating characteristic curve could not differentiate between anthropometric variables (p-values ≥ 0.24), the relative integrated discrimination improvement statistic showed an enhancement in the discrimination capabilities of models using WHR for cardiovascular outcomes, except for cerebrovascular events.</p></sec><sec id="S3"><title>Conclusion</title><p id="P3">Strengths of associations and discrimination statistics suggested that WHR was the best predictor of cardiovascular events and mortality in patients with type-2-diabetes and BMI the worst.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101192000</journal-id><journal-id journal-id-type="pubmed-jr-id">31730</journal-id><journal-id journal-id-type="nlm-ta">Eur J Cardiovasc Prev Rehabil</journal-id><journal-id journal-id-type="iso-abbrev">Eur J Cardiovasc Prev Rehabil</journal-id><journal-title-group><journal-title>European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology</journal-title></journal-title-group><issn pub-type="ppub">1741-8267</issn><issn pub-type="epub">1741-8275</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20628304</article-id><article-id pub-id-type="pmc">4170784</article-id><article-id pub-id-type="doi">10.1097/HJR.0b013e32833c1aa3</article-id><article-id pub-id-type="manuscript">EMS60287</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type 2 diabetes: a prospective cohort study from ADVANCE</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Czernichow</surname><given-names>Sébastien</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Kengne</surname><given-names>Andre-Pascal</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Huxley</surname><given-names>Rachel R.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Batty</surname><given-names>G David</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>de Galan</surname><given-names>Bastiaan</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Grobbee</surname><given-names>Diederick</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Pillai</surname><given-names>Avinesh</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zoungas</surname><given-names>Sophia</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Marre</surname><given-names>Michel</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Woodward</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Neal</surname><given-names>Bruce</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chalmers</surname><given-names>John</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><on-behalf-of>on behalf of the ADVANCE Collaborative Group</on-behalf-of></contrib-group><aff id="A1"><label>1</label>The George Institute for International Health; The University of Sydney, Australia</aff><aff id="A2"><label>2</label>Department of Public Health, Avicenne Hospital; University of Paris 13, France</aff><aff id="A3"><label>3</label>Medical Research Council Social & Public Health Sciences Unit, Glasgow, UK</aff><aff id="A4"><label>4</label>Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands</aff><aff id="A5"><label>5</label>Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands</aff><aff id="A6"><label>6</label>Monash University, Melbourne, VIC, Australia</aff><aff id="A7"><label>7</label>Endocrinologie, Diabétologie & Nutrition, Hôpital Bichat-Claude Bernard, France</aff><author-notes><corresp id="CR1">Address for reprint and correspondence: A/Prof. Sébastien Czernichow Unité de Recherche en Epidémiologie Nutritionnelle. Faculté de médecine SMBH. 74, rue Marcel Cachin, 93017 Bobigny, France Tel: +33 1 48 38 89 53, Fax: +33 1 48 38 89 31 <email>czernichow@uren.smbh.univ-paris13.fr</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>4</day><month>9</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>22</day><month>9</month><year>2014</year></pub-date><volume>18</volume><issue>2</issue><fpage>312</fpage><lpage>319</lpage><pmc-comment>elocation-id from pubmed: 10.1097/HJR.0b013e32833c1aa3</pmc-comment>
<abstract><sec id="S1"><title>Aims</title><p id="P1">The aim of this study was to compare the strength of associations and discrimination capability of body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) with cardiovascular disease risk in individuals with type-2-diabetes.</p></sec><sec id="S2"><title>Methods and results</title><p id="P2">11,140 men and women were followed for a mean of 4.8 years. Cox proportional hazard models were used to compute the hazard ratios (HR) and 95% confidence intervals (95% CI) for one standard deviation (SD) increase in baseline BMI (SD: 5 kg/m<sup>2</sup>), WC (SD: 13 cm) and WHR (SD: 0.08) with cardiovascular disease risk. After adjustment, HR (95% CI) for WC were 1.10 (1.03-1.18) for cardiovascular events, 1.13 (1.03-1.24) for coronary events, and 1.08 (0.98-1.19) for cardiovascular deaths. Estimates for WHR were 1.12 (1.05-1.19), 1.17 (1.08-1.28) and 1.19 (1.09-1.31). BMI was not related to any of these outcomes. While the receiver operating characteristic curve could not differentiate between anthropometric variables (p-values ≥ 0.24), the relative integrated discrimination improvement statistic showed an enhancement in the discrimination capabilities of models using WHR for cardiovascular outcomes, except for cerebrovascular events.</p></sec><sec id="S3"><title>Conclusion</title><p id="P3">Strengths of associations and discrimination statistics suggested that WHR was the best predictor of cardiovascular events and mortality in patients with type-2-diabetes and BMI the worst.</p></sec></abstract><kwd-group><kwd>body mass index</kwd><kwd>waist circumference</kwd><kwd>waist-to-hip ratio</kwd><kwd>type 2 diabetes</kwd><kwd>cardiovascular disease</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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