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<title xml:lang="en">Prevalence of Esophageal Atresia among 18 International Birth Defects Surveillance Programs</title>
<author>
<name sortKey="Nassar, Natasha" sort="Nassar, Natasha" uniqKey="Nassar N" first="Natasha" last="Nassar">Natasha Nassar</name>
<affiliation>
<nlm:aff id="A1">Population Perinatal Health Research, Kolling Institute of Medical Research, University of Sydney, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Leoncini, Emanuele" sort="Leoncini, Emanuele" uniqKey="Leoncini E" first="Emanuele" last="Leoncini">Emanuele Leoncini</name>
<affiliation>
<nlm:aff id="A2">Center of the International Clearinghouse for Birth Defects Surveillance and Research, Rome, Italy</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Amar, Emmanuelle" sort="Amar, Emmanuelle" uniqKey="Amar E" first="Emmanuelle" last="Amar">Emmanuelle Amar</name>
<affiliation>
<nlm:aff id="A3">Rhone-Alps Registry of Birth Defects REMERA, Lyon, France</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Arteaga Vazquez, Jazmin" sort="Arteaga Vazquez, Jazmin" uniqKey="Arteaga Vazquez J" first="Jazmín" last="Arteaga-Vázquez">Jazmín Arteaga-Vázquez</name>
<affiliation>
<nlm:aff id="A4">Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Departamento de Genética, Registro y Vigilancia Epidemiológica de Malformaciones Congénitas, Mexico City, Mexico</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bakker, Marian K" sort="Bakker, Marian K" uniqKey="Bakker M" first="Marian K." last="Bakker">Marian K. Bakker</name>
<affiliation>
<nlm:aff id="A5">EUROCAT Northern Netherlands, Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bower, Carol" sort="Bower, Carol" uniqKey="Bower C" first="Carol" last="Bower">Carol Bower</name>
<affiliation>
<nlm:aff id="A6">Western Australian Register of Developmental Anomalies, Perth, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Canfield, Mark A" sort="Canfield, Mark A" uniqKey="Canfield M" first="Mark A." last="Canfield">Mark A. Canfield</name>
<affiliation>
<nlm:aff id="A7">Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Castilla, Eduardo E" sort="Castilla, Eduardo E" uniqKey="Castilla E" first="Eduardo E." last="Castilla">Eduardo E. Castilla</name>
<affiliation>
<nlm:aff id="A8">Instituto Nacional de Genética Médica Populacional, Rio de Janeiro, Brazil</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A9">Estudio Colaborativo Latino Americano de Malformaciones Congenitas at Centro de Educación Médica e Investigación Clínica, Buenos Aires, Argentina</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A10">Estudio Colaborativo Latino Americano de Malformaciones Congenitas at Laboratório de Epidemiologia de Malformações Congênitas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cocchi, Guido" sort="Cocchi, Guido" uniqKey="Cocchi G" first="Guido" last="Cocchi">Guido Cocchi</name>
<affiliation>
<nlm:aff id="A11">Indagine Malformazioni congenite Emilia Romagna Registry, Department of Pediatrics, Bologna University, Bologna, Italy</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Correa, Adolfo" sort="Correa, Adolfo" uniqKey="Correa A" first="Adolfo" last="Correa">Adolfo Correa</name>
<affiliation>
<nlm:aff id="A12">Metropolitan Atlanta Congenital Defects Program, Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A13">Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Csaky Szunyogh, Melinda" sort="Csaky Szunyogh, Melinda" uniqKey="Csaky Szunyogh M" first="Melinda" last="Csáky-Szunyogh">Melinda Csáky-Szunyogh</name>
<affiliation>
<nlm:aff id="A14">Department of Hungarian Congenital Abnormality Registry and Surveillance, National Center for Healthcare Audit and Inspection, Budapest, Hungary</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Feldkamp, Marcia L" sort="Feldkamp, Marcia L" uniqKey="Feldkamp M" first="Marcia L." last="Feldkamp">Marcia L. Feldkamp</name>
<affiliation>
<nlm:aff id="A15">Division of Medical Genetics, University of Utah Health Sciences Center, Salt Lake City, Utah</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A16">Utah Birth Defect Network, Utah Department of Health, Salt Lake City, Utah</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Khoshnood, Babak" sort="Khoshnood, Babak" uniqKey="Khoshnood B" first="Babak" last="Khoshnood">Babak Khoshnood</name>
<affiliation>
<nlm:aff id="A17">Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche S953, Epidemiological Research on Perinatal Health and Women’s and Children’s Health, Hôpital Cochin and UPMC University, Paris, France</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Landau, Danielle" sort="Landau, Danielle" uniqKey="Landau D" first="Danielle" last="Landau">Danielle Landau</name>
<affiliation>
<nlm:aff id="A18">Department of Neonatology, Soroka University Medical Center, Beer-Sheba, Israel</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lelong, Nathalie" sort="Lelong, Nathalie" uniqKey="Lelong N" first="Nathalie" last="Lelong">Nathalie Lelong</name>
<affiliation>
<nlm:aff id="A17">Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche S953, Epidemiological Research on Perinatal Health and Women’s and Children’s Health, Hôpital Cochin and UPMC University, Paris, France</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="L Pez Camelo, Jorge S" sort="L Pez Camelo, Jorge S" uniqKey="L Pez Camelo J" first="Jorge S." last="L Pez-Camelo">Jorge S. L Pez-Camelo</name>
<affiliation>
<nlm:aff id="A8">Instituto Nacional de Genética Médica Populacional, Rio de Janeiro, Brazil</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A9">Estudio Colaborativo Latino Americano de Malformaciones Congenitas at Centro de Educación Médica e Investigación Clínica, Buenos Aires, Argentina</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lowry, R Brian" sort="Lowry, R Brian" uniqKey="Lowry R" first="R. Brian" last="Lowry">R. Brian Lowry</name>
<affiliation>
<nlm:aff id="A19">Alberta Congenital Anomalies Surveillance System, Alberta Health and Wellness, Calgary, Canada</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mcdonnell, Robert" sort="Mcdonnell, Robert" uniqKey="Mcdonnell R" first="Robert" last="Mcdonnell">Robert Mcdonnell</name>
<affiliation>
<nlm:aff id="A20">Dublin EUROCAT Registry, Health Service Executive, Dublin, Ireland</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Merlob, Paul" sort="Merlob, Paul" uniqKey="Merlob P" first="Paul" last="Merlob">Paul Merlob</name>
<affiliation>
<nlm:aff id="A21">Department of Neonatology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Metneki, Julia" sort="Metneki, Julia" uniqKey="Metneki J" first="Julia" last="Métneki">Julia Métneki</name>
<affiliation>
<nlm:aff id="A14">Department of Hungarian Congenital Abnormality Registry and Surveillance, National Center for Healthcare Audit and Inspection, Budapest, Hungary</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Morgan, Margery" sort="Morgan, Margery" uniqKey="Morgan M" first="Margery" last="Morgan">Margery Morgan</name>
<affiliation>
<nlm:aff id="A22">Congenital Anomaly Register for Wales, Singleton Hospital, Swansea, Wales, United Kingdom</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mutchinick, Osvaldo M" sort="Mutchinick, Osvaldo M" uniqKey="Mutchinick O" first="Osvaldo M." last="Mutchinick">Osvaldo M. Mutchinick</name>
<affiliation>
<nlm:aff id="A4">Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Departamento de Genética, Registro y Vigilancia Epidemiológica de Malformaciones Congénitas, Mexico City, Mexico</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Palmer, Miland N" sort="Palmer, Miland N" uniqKey="Palmer M" first="Miland N." last="Palmer">Miland N. Palmer</name>
<affiliation>
<nlm:aff id="A16">Utah Birth Defect Network, Utah Department of Health, Salt Lake City, Utah</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Rissmann, Anke" sort="Rissmann, Anke" uniqKey="Rissmann A" first="Anke" last="Rissmann">Anke Rissmann</name>
<affiliation>
<nlm:aff id="A23">Malformation Monitoring Centre Saxony-Anhalt, Otto-von-Guericke University Magdeburg, Germany</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Siffel, Csaba" sort="Siffel, Csaba" uniqKey="Siffel C" first="Csaba" last="Siffel">Csaba Siffel</name>
<affiliation>
<nlm:aff id="A12">Metropolitan Atlanta Congenital Defects Program, Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sipek, Antonin" sort="Sipek, Antonin" uniqKey="Sipek A" first="Antonin" last="Sìpek">Antonin Sìpek</name>
<affiliation>
<nlm:aff id="A24">National Registry of Congenital Anomalies of the Czech Republic, Department of Medical Genetics, Thomayer University Hospital, Prague, Czech Republic</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Szabova, Elena" sort="Szabova, Elena" uniqKey="Szabova E" first="Elena" last="Szabova">Elena Szabova</name>
<affiliation>
<nlm:aff id="A25">Slovak Teratologic Information Centre, Slovak Medical University, Bratislava, Slovak Republic</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Tucker, David" sort="Tucker, David" uniqKey="Tucker D" first="David" last="Tucker">David Tucker</name>
<affiliation>
<nlm:aff id="A22">Congenital Anomaly Register for Wales, Singleton Hospital, Swansea, Wales, United Kingdom</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mastroiacovo, Pierpaolo" sort="Mastroiacovo, Pierpaolo" uniqKey="Mastroiacovo P" first="Pierpaolo" last="Mastroiacovo">Pierpaolo Mastroiacovo</name>
<affiliation>
<nlm:aff id="A2">Center of the International Clearinghouse for Birth Defects Surveillance and Research, Rome, Italy</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">22945024</idno>
<idno type="pmc">4467200</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467200</idno>
<idno type="RBID">PMC:4467200</idno>
<idno type="doi">10.1002/bdra.23067</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">001E14</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E14</idno>
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<analytic>
<title xml:lang="en" level="a" type="main">Prevalence of Esophageal Atresia among 18 International Birth Defects Surveillance Programs</title>
<author>
<name sortKey="Nassar, Natasha" sort="Nassar, Natasha" uniqKey="Nassar N" first="Natasha" last="Nassar">Natasha Nassar</name>
<affiliation>
<nlm:aff id="A1">Population Perinatal Health Research, Kolling Institute of Medical Research, University of Sydney, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Leoncini, Emanuele" sort="Leoncini, Emanuele" uniqKey="Leoncini E" first="Emanuele" last="Leoncini">Emanuele Leoncini</name>
<affiliation>
<nlm:aff id="A2">Center of the International Clearinghouse for Birth Defects Surveillance and Research, Rome, Italy</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Amar, Emmanuelle" sort="Amar, Emmanuelle" uniqKey="Amar E" first="Emmanuelle" last="Amar">Emmanuelle Amar</name>
<affiliation>
<nlm:aff id="A3">Rhone-Alps Registry of Birth Defects REMERA, Lyon, France</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Arteaga Vazquez, Jazmin" sort="Arteaga Vazquez, Jazmin" uniqKey="Arteaga Vazquez J" first="Jazmín" last="Arteaga-Vázquez">Jazmín Arteaga-Vázquez</name>
<affiliation>
<nlm:aff id="A4">Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Departamento de Genética, Registro y Vigilancia Epidemiológica de Malformaciones Congénitas, Mexico City, Mexico</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bakker, Marian K" sort="Bakker, Marian K" uniqKey="Bakker M" first="Marian K." last="Bakker">Marian K. Bakker</name>
<affiliation>
<nlm:aff id="A5">EUROCAT Northern Netherlands, Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bower, Carol" sort="Bower, Carol" uniqKey="Bower C" first="Carol" last="Bower">Carol Bower</name>
<affiliation>
<nlm:aff id="A6">Western Australian Register of Developmental Anomalies, Perth, Australia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Canfield, Mark A" sort="Canfield, Mark A" uniqKey="Canfield M" first="Mark A." last="Canfield">Mark A. Canfield</name>
<affiliation>
<nlm:aff id="A7">Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Castilla, Eduardo E" sort="Castilla, Eduardo E" uniqKey="Castilla E" first="Eduardo E." last="Castilla">Eduardo E. Castilla</name>
<affiliation>
<nlm:aff id="A8">Instituto Nacional de Genética Médica Populacional, Rio de Janeiro, Brazil</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A9">Estudio Colaborativo Latino Americano de Malformaciones Congenitas at Centro de Educación Médica e Investigación Clínica, Buenos Aires, Argentina</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A10">Estudio Colaborativo Latino Americano de Malformaciones Congenitas at Laboratório de Epidemiologia de Malformações Congênitas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cocchi, Guido" sort="Cocchi, Guido" uniqKey="Cocchi G" first="Guido" last="Cocchi">Guido Cocchi</name>
<affiliation>
<nlm:aff id="A11">Indagine Malformazioni congenite Emilia Romagna Registry, Department of Pediatrics, Bologna University, Bologna, Italy</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Correa, Adolfo" sort="Correa, Adolfo" uniqKey="Correa A" first="Adolfo" last="Correa">Adolfo Correa</name>
<affiliation>
<nlm:aff id="A12">Metropolitan Atlanta Congenital Defects Program, Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A13">Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Csaky Szunyogh, Melinda" sort="Csaky Szunyogh, Melinda" uniqKey="Csaky Szunyogh M" first="Melinda" last="Csáky-Szunyogh">Melinda Csáky-Szunyogh</name>
<affiliation>
<nlm:aff id="A14">Department of Hungarian Congenital Abnormality Registry and Surveillance, National Center for Healthcare Audit and Inspection, Budapest, Hungary</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Feldkamp, Marcia L" sort="Feldkamp, Marcia L" uniqKey="Feldkamp M" first="Marcia L." last="Feldkamp">Marcia L. Feldkamp</name>
<affiliation>
<nlm:aff id="A15">Division of Medical Genetics, University of Utah Health Sciences Center, Salt Lake City, Utah</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A16">Utah Birth Defect Network, Utah Department of Health, Salt Lake City, Utah</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Khoshnood, Babak" sort="Khoshnood, Babak" uniqKey="Khoshnood B" first="Babak" last="Khoshnood">Babak Khoshnood</name>
<affiliation>
<nlm:aff id="A17">Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche S953, Epidemiological Research on Perinatal Health and Women’s and Children’s Health, Hôpital Cochin and UPMC University, Paris, France</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Landau, Danielle" sort="Landau, Danielle" uniqKey="Landau D" first="Danielle" last="Landau">Danielle Landau</name>
<affiliation>
<nlm:aff id="A18">Department of Neonatology, Soroka University Medical Center, Beer-Sheba, Israel</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lelong, Nathalie" sort="Lelong, Nathalie" uniqKey="Lelong N" first="Nathalie" last="Lelong">Nathalie Lelong</name>
<affiliation>
<nlm:aff id="A17">Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche S953, Epidemiological Research on Perinatal Health and Women’s and Children’s Health, Hôpital Cochin and UPMC University, Paris, France</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="L Pez Camelo, Jorge S" sort="L Pez Camelo, Jorge S" uniqKey="L Pez Camelo J" first="Jorge S." last="L Pez-Camelo">Jorge S. L Pez-Camelo</name>
<affiliation>
<nlm:aff id="A8">Instituto Nacional de Genética Médica Populacional, Rio de Janeiro, Brazil</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A9">Estudio Colaborativo Latino Americano de Malformaciones Congenitas at Centro de Educación Médica e Investigación Clínica, Buenos Aires, Argentina</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lowry, R Brian" sort="Lowry, R Brian" uniqKey="Lowry R" first="R. Brian" last="Lowry">R. Brian Lowry</name>
<affiliation>
<nlm:aff id="A19">Alberta Congenital Anomalies Surveillance System, Alberta Health and Wellness, Calgary, Canada</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mcdonnell, Robert" sort="Mcdonnell, Robert" uniqKey="Mcdonnell R" first="Robert" last="Mcdonnell">Robert Mcdonnell</name>
<affiliation>
<nlm:aff id="A20">Dublin EUROCAT Registry, Health Service Executive, Dublin, Ireland</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Merlob, Paul" sort="Merlob, Paul" uniqKey="Merlob P" first="Paul" last="Merlob">Paul Merlob</name>
<affiliation>
<nlm:aff id="A21">Department of Neonatology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Metneki, Julia" sort="Metneki, Julia" uniqKey="Metneki J" first="Julia" last="Métneki">Julia Métneki</name>
<affiliation>
<nlm:aff id="A14">Department of Hungarian Congenital Abnormality Registry and Surveillance, National Center for Healthcare Audit and Inspection, Budapest, Hungary</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Morgan, Margery" sort="Morgan, Margery" uniqKey="Morgan M" first="Margery" last="Morgan">Margery Morgan</name>
<affiliation>
<nlm:aff id="A22">Congenital Anomaly Register for Wales, Singleton Hospital, Swansea, Wales, United Kingdom</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mutchinick, Osvaldo M" sort="Mutchinick, Osvaldo M" uniqKey="Mutchinick O" first="Osvaldo M." last="Mutchinick">Osvaldo M. Mutchinick</name>
<affiliation>
<nlm:aff id="A4">Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Departamento de Genética, Registro y Vigilancia Epidemiológica de Malformaciones Congénitas, Mexico City, Mexico</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Palmer, Miland N" sort="Palmer, Miland N" uniqKey="Palmer M" first="Miland N." last="Palmer">Miland N. Palmer</name>
<affiliation>
<nlm:aff id="A16">Utah Birth Defect Network, Utah Department of Health, Salt Lake City, Utah</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Rissmann, Anke" sort="Rissmann, Anke" uniqKey="Rissmann A" first="Anke" last="Rissmann">Anke Rissmann</name>
<affiliation>
<nlm:aff id="A23">Malformation Monitoring Centre Saxony-Anhalt, Otto-von-Guericke University Magdeburg, Germany</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Siffel, Csaba" sort="Siffel, Csaba" uniqKey="Siffel C" first="Csaba" last="Siffel">Csaba Siffel</name>
<affiliation>
<nlm:aff id="A12">Metropolitan Atlanta Congenital Defects Program, Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sipek, Antonin" sort="Sipek, Antonin" uniqKey="Sipek A" first="Antonin" last="Sìpek">Antonin Sìpek</name>
<affiliation>
<nlm:aff id="A24">National Registry of Congenital Anomalies of the Czech Republic, Department of Medical Genetics, Thomayer University Hospital, Prague, Czech Republic</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Szabova, Elena" sort="Szabova, Elena" uniqKey="Szabova E" first="Elena" last="Szabova">Elena Szabova</name>
<affiliation>
<nlm:aff id="A25">Slovak Teratologic Information Centre, Slovak Medical University, Bratislava, Slovak Republic</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Tucker, David" sort="Tucker, David" uniqKey="Tucker D" first="David" last="Tucker">David Tucker</name>
<affiliation>
<nlm:aff id="A22">Congenital Anomaly Register for Wales, Singleton Hospital, Swansea, Wales, United Kingdom</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mastroiacovo, Pierpaolo" sort="Mastroiacovo, Pierpaolo" uniqKey="Mastroiacovo P" first="Pierpaolo" last="Mastroiacovo">Pierpaolo Mastroiacovo</name>
<affiliation>
<nlm:aff id="A2">Center of the International Clearinghouse for Birth Defects Surveillance and Research, Rome, Italy</nlm:aff>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Birth defects research. Part A, Clinical and molecular teratology</title>
<idno type="ISSN">1542-0752</idno>
<idno type="eISSN">1542-0760</idno>
<imprint>
<date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<sec id="S1">
<title>BACKGROUND</title>
<p id="P1">The prevalence of esophageal atresia (EA) has been shown to vary across different geographical settings. Investigation of geographical differences may provide an insight into the underlying etiology of EA.</p>
</sec>
<sec id="S2">
<title>METHODS</title>
<p id="P2">The study population comprised infants diagnosed with EA during 1998 to 2007 from 18 of the 46 birth defects surveillance programs, members of the International Clearinghouse for Birth Defects Surveillance and Research. Total prevalence per 10,000 births for EA was defined as the total number of cases in live births, stillbirths, and elective termination of pregnancy for fetal anomaly (ETOPFA) divided by the total number of all births in the population.</p>
</sec>
<sec id="S3">
<title>RESULTS</title>
<p id="P3">Among the participating programs, a total of 2943 cases of EA were diagnosed with an average prevalence of 2.44 (95% confidence interval [CI], 2.35–2.53) per 10,000 births, ranging between 1.77 and 3.68 per 10,000 births. Of all infants diagnosed with EA, 2761 (93.8%) were live births, 82 (2.8%) stillbirths, 89 (3.0%) ETOPFA, and 11 (0.4%) had unknown outcomes. The majority of cases (2020, 68.6%), had a reported EA with fistula, 749 (25.5%) were without fistula, and 174 (5.9%) were registered with an unspecified code.</p>
</sec>
<sec id="S4">
<title>CONCLUSIONS</title>
<p id="P4">On average, EA affected 1 in 4099 births (95% CI, 1 in 3954–4251 births) with prevalence varying across different geographical settings, but relatively consistent over time and comparable between surveillance programs. Findings suggest that differences in the prevalence observed among programs are likely to be attributable to variability in population ethnic compositions or issues in reporting or registration procedures of EA, rather than a real risk occurrence difference.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-journal-id">101155107</journal-id>
<journal-id journal-id-type="pubmed-jr-id">30290</journal-id>
<journal-id journal-id-type="nlm-ta">Birth Defects Res A Clin Mol Teratol</journal-id>
<journal-id journal-id-type="iso-abbrev">Birth Defects Res. Part A Clin. Mol. Teratol.</journal-id>
<journal-title-group>
<journal-title>Birth defects research. Part A, Clinical and molecular teratology</journal-title>
</journal-title-group>
<issn pub-type="ppub">1542-0752</issn>
<issn pub-type="epub">1542-0760</issn>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">22945024</article-id>
<article-id pub-id-type="pmc">4467200</article-id>
<article-id pub-id-type="doi">10.1002/bdra.23067</article-id>
<article-id pub-id-type="manuscript">HHSPA698092</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Prevalence of Esophageal Atresia among 18 International Birth Defects Surveillance Programs</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Nassar</surname>
<given-names>Natasha</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Leoncini</surname>
<given-names>Emanuele</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Amar</surname>
<given-names>Emmanuelle</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Arteaga-Vázquez</surname>
<given-names>Jazmín</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bakker</surname>
<given-names>Marian K.</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bower</surname>
<given-names>Carol</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Canfield</surname>
<given-names>Mark A.</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Castilla</surname>
<given-names>Eduardo E.</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A9">9</xref>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Cocchi</surname>
<given-names>Guido</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Correa</surname>
<given-names>Adolfo</given-names>
</name>
<xref ref-type="aff" rid="A12">12</xref>
<xref ref-type="aff" rid="A13">13</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Csáky-Szunyogh</surname>
<given-names>Melinda</given-names>
</name>
<xref ref-type="aff" rid="A14">14</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Feldkamp</surname>
<given-names>Marcia L.</given-names>
</name>
<xref ref-type="aff" rid="A15">15</xref>
<xref ref-type="aff" rid="A16">16</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Khoshnood</surname>
<given-names>Babak</given-names>
</name>
<xref ref-type="aff" rid="A17">17</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Landau</surname>
<given-names>Danielle</given-names>
</name>
<xref ref-type="aff" rid="A18">18</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lelong</surname>
<given-names>Nathalie</given-names>
</name>
<xref ref-type="aff" rid="A17">17</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>López-Camelo</surname>
<given-names>Jorge S.</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lowry</surname>
<given-names>R. Brian</given-names>
</name>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>McDonnell</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="A20">20</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Merlob</surname>
<given-names>Paul</given-names>
</name>
<xref ref-type="aff" rid="A21">21</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Métneki</surname>
<given-names>Julia</given-names>
</name>
<xref ref-type="aff" rid="A14">14</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Morgan</surname>
<given-names>Margery</given-names>
</name>
<xref ref-type="aff" rid="A22">22</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mutchinick</surname>
<given-names>Osvaldo M.</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Palmer</surname>
<given-names>Miland N.</given-names>
</name>
<xref ref-type="aff" rid="A16">16</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Rissmann</surname>
<given-names>Anke</given-names>
</name>
<xref ref-type="aff" rid="A23">23</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Siffel</surname>
<given-names>Csaba</given-names>
</name>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sìpek</surname>
<given-names>Antonin</given-names>
</name>
<xref ref-type="aff" rid="A24">24</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Szabova</surname>
<given-names>Elena</given-names>
</name>
<xref ref-type="aff" rid="A25">25</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Tucker</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="A22">22</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mastroiacovo</surname>
<given-names>Pierpaolo</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
</contrib-group>
<aff id="A1">
<label>1</label>
Population Perinatal Health Research, Kolling Institute of Medical Research, University of Sydney, Australia</aff>
<aff id="A2">
<label>2</label>
Center of the International Clearinghouse for Birth Defects Surveillance and Research, Rome, Italy</aff>
<aff id="A3">
<label>3</label>
Rhone-Alps Registry of Birth Defects REMERA, Lyon, France</aff>
<aff id="A4">
<label>4</label>
Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Departamento de Genética, Registro y Vigilancia Epidemiológica de Malformaciones Congénitas, Mexico City, Mexico</aff>
<aff id="A5">
<label>5</label>
EUROCAT Northern Netherlands, Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands</aff>
<aff id="A6">
<label>6</label>
Western Australian Register of Developmental Anomalies, Perth, Australia</aff>
<aff id="A7">
<label>7</label>
Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas</aff>
<aff id="A8">
<label>8</label>
Instituto Nacional de Genética Médica Populacional, Rio de Janeiro, Brazil</aff>
<aff id="A9">
<label>9</label>
Estudio Colaborativo Latino Americano de Malformaciones Congenitas at Centro de Educación Médica e Investigación Clínica, Buenos Aires, Argentina</aff>
<aff id="A10">
<label>10</label>
Estudio Colaborativo Latino Americano de Malformaciones Congenitas at Laboratório de Epidemiologia de Malformações Congênitas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil</aff>
<aff id="A11">
<label>11</label>
Indagine Malformazioni congenite Emilia Romagna Registry, Department of Pediatrics, Bologna University, Bologna, Italy</aff>
<aff id="A12">
<label>12</label>
Metropolitan Atlanta Congenital Defects Program, Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia</aff>
<aff id="A13">
<label>13</label>
Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi</aff>
<aff id="A14">
<label>14</label>
Department of Hungarian Congenital Abnormality Registry and Surveillance, National Center for Healthcare Audit and Inspection, Budapest, Hungary</aff>
<aff id="A15">
<label>15</label>
Division of Medical Genetics, University of Utah Health Sciences Center, Salt Lake City, Utah</aff>
<aff id="A16">
<label>16</label>
Utah Birth Defect Network, Utah Department of Health, Salt Lake City, Utah</aff>
<aff id="A17">
<label>17</label>
Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche S953, Epidemiological Research on Perinatal Health and Women’s and Children’s Health, Hôpital Cochin and UPMC University, Paris, France</aff>
<aff id="A18">
<label>18</label>
Department of Neonatology, Soroka University Medical Center, Beer-Sheba, Israel</aff>
<aff id="A19">
<label>19</label>
Alberta Congenital Anomalies Surveillance System, Alberta Health and Wellness, Calgary, Canada</aff>
<aff id="A20">
<label>20</label>
Dublin EUROCAT Registry, Health Service Executive, Dublin, Ireland</aff>
<aff id="A21">
<label>21</label>
Department of Neonatology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel</aff>
<aff id="A22">
<label>22</label>
Congenital Anomaly Register for Wales, Singleton Hospital, Swansea, Wales, United Kingdom</aff>
<aff id="A23">
<label>23</label>
Malformation Monitoring Centre Saxony-Anhalt, Otto-von-Guericke University Magdeburg, Germany</aff>
<aff id="A24">
<label>24</label>
National Registry of Congenital Anomalies of the Czech Republic, Department of Medical Genetics, Thomayer University Hospital, Prague, Czech Republic</aff>
<aff id="A25">
<label>25</label>
Slovak Teratologic Information Centre, Slovak Medical University, Bratislava, Slovak Republic</aff>
<pub-date pub-type="nihms-submitted">
<day>9</day>
<month>6</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub">
<day>03</day>
<month>9</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="ppub">
<month>11</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>15</day>
<month>6</month>
<year>2015</year>
</pub-date>
<volume>94</volume>
<issue>11</issue>
<fpage>893</fpage>
<lpage>899</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/bdra.23067</pmc-comment>
<permissions>
<copyright-statement>© 2012 Wiley Periodicals, Inc.</copyright-statement>
<copyright-year>2012</copyright-year>
</permissions>
<abstract>
<sec id="S1">
<title>BACKGROUND</title>
<p id="P1">The prevalence of esophageal atresia (EA) has been shown to vary across different geographical settings. Investigation of geographical differences may provide an insight into the underlying etiology of EA.</p>
</sec>
<sec id="S2">
<title>METHODS</title>
<p id="P2">The study population comprised infants diagnosed with EA during 1998 to 2007 from 18 of the 46 birth defects surveillance programs, members of the International Clearinghouse for Birth Defects Surveillance and Research. Total prevalence per 10,000 births for EA was defined as the total number of cases in live births, stillbirths, and elective termination of pregnancy for fetal anomaly (ETOPFA) divided by the total number of all births in the population.</p>
</sec>
<sec id="S3">
<title>RESULTS</title>
<p id="P3">Among the participating programs, a total of 2943 cases of EA were diagnosed with an average prevalence of 2.44 (95% confidence interval [CI], 2.35–2.53) per 10,000 births, ranging between 1.77 and 3.68 per 10,000 births. Of all infants diagnosed with EA, 2761 (93.8%) were live births, 82 (2.8%) stillbirths, 89 (3.0%) ETOPFA, and 11 (0.4%) had unknown outcomes. The majority of cases (2020, 68.6%), had a reported EA with fistula, 749 (25.5%) were without fistula, and 174 (5.9%) were registered with an unspecified code.</p>
</sec>
<sec id="S4">
<title>CONCLUSIONS</title>
<p id="P4">On average, EA affected 1 in 4099 births (95% CI, 1 in 3954–4251 births) with prevalence varying across different geographical settings, but relatively consistent over time and comparable between surveillance programs. Findings suggest that differences in the prevalence observed among programs are likely to be attributable to variability in population ethnic compositions or issues in reporting or registration procedures of EA, rather than a real risk occurrence difference.</p>
</sec>
</abstract>
<kwd-group>
<kwd>esophageal atresia</kwd>
<kwd>congenital anomalies</kwd>
<kwd>prevalence</kwd>
<kwd>epidemiology</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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