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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anti-apoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3<sup>+</sup> regulatory T cells</title><author><name sortKey="Pierson, Wim" sort="Pierson, Wim" uniqKey="Pierson W" first="Wim" last="Pierson">Wim Pierson</name><affiliation><nlm:aff id="A1">Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Cauwe, Benedicte" sort="Cauwe, Benedicte" uniqKey="Cauwe B" first="Bénédicte" last="Cauwe">Bénédicte Cauwe</name><affiliation><nlm:aff id="A1">Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Policheni, Antonia" sort="Policheni, Antonia" uniqKey="Policheni A" first="Antonia" last="Policheni">Antonia Policheni</name><affiliation><nlm:aff id="A3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Medical Biology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Schlenner, Susan M" sort="Schlenner, Susan M" uniqKey="Schlenner S" first="Susan M." last="Schlenner">Susan M. Schlenner</name><affiliation><nlm:aff id="A1">Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Franckaert, Dean" sort="Franckaert, Dean" uniqKey="Franckaert D" first="Dean" last="Franckaert">Dean Franckaert</name><affiliation><nlm:aff id="A1">Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Berges, Julien" sort="Berges, Julien" uniqKey="Berges J" first="Julien" last="Berges">Julien Berges</name><affiliation><nlm:aff id="A5">Unité de Biologie des Populations Lymphocytaires, Department of Immunology, Institut Pasteur, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Centre national de la recherché scientifique, URA 1961, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Humblet Baron, Stephanie" sort="Humblet Baron, Stephanie" uniqKey="Humblet Baron S" first="Stephanie" last="Humblet-Baron">Stephanie Humblet-Baron</name><affiliation><nlm:aff id="A1">Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Schonefeldt, Susann" sort="Schonefeldt, Susann" uniqKey="Schonefeldt S" first="Susann" last="Schonefeldt">Susann Schonefeldt</name><affiliation><nlm:aff id="A1">Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Herold, Marco J" sort="Herold, Marco J" uniqKey="Herold M" first="Marco J." last="Herold">Marco J. Herold</name><affiliation><nlm:aff id="A3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Medical Biology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Hildeman, David" sort="Hildeman, David" uniqKey="Hildeman D" first="David" last="Hildeman">David Hildeman</name><affiliation><nlm:aff id="A7">Division of Immunobiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Children’s Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff></affiliation></author><author><name sortKey="Strasser, Andreas" sort="Strasser, Andreas" uniqKey="Strasser A" first="Andreas" last="Strasser">Andreas Strasser</name><affiliation><nlm:aff id="A3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Medical Biology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Bouillet, Philippe" sort="Bouillet, Philippe" uniqKey="Bouillet P" first="Philippe" last="Bouillet">Philippe Bouillet</name><affiliation><nlm:aff id="A3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Medical Biology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Lu, Li Fan" sort="Lu, Li Fan" uniqKey="Lu L" first="Li-Fan" last="Lu">Li-Fan Lu</name><affiliation><nlm:aff id="A9">Section of Molecular Biology, Division of Biological Sciences, University of California–San Diego, La Jolla, California, USA</nlm:aff></affiliation></author><author><name sortKey="Matthys, Patrick" sort="Matthys, Patrick" uniqKey="Matthys P" first="Patrick" last="Matthys">Patrick Matthys</name><affiliation><nlm:aff id="A10">Laboratory of Immunobiology, Rega Institute, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Freitas, Antonio A" sort="Freitas, Antonio A" uniqKey="Freitas A" first="Antonio A." last="Freitas">Antonio A. Freitas</name><affiliation><nlm:aff id="A5">Unité de Biologie des Populations Lymphocytaires, Department of Immunology, Institut Pasteur, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Centre national de la recherché scientifique, URA 1961, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Luther, Rita J" sort="Luther, Rita J" uniqKey="Luther R" first="Rita J." last="Luther">Rita J. Luther</name><affiliation><nlm:aff id="A11">Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA</nlm:aff></affiliation></author><author><name sortKey="Weaver, Casey T" sort="Weaver, Casey T" uniqKey="Weaver C" first="Casey T." last="Weaver">Casey T. Weaver</name><affiliation><nlm:aff id="A11">Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA</nlm:aff></affiliation></author><author><name sortKey="Dooley, James" sort="Dooley, James" uniqKey="Dooley J" first="James" last="Dooley">James Dooley</name><affiliation><nlm:aff id="A1">Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Gray, Daniel H D" sort="Gray, Daniel H D" uniqKey="Gray D" first="Daniel H. D." last="Gray">Daniel H. D. Gray</name><affiliation><nlm:aff id="A3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Medical Biology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Liston, Adrian" sort="Liston, Adrian" uniqKey="Liston A" first="Adrian" last="Liston">Adrian Liston</name><affiliation><nlm:aff id="A1">Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23852275</idno><idno type="pmc">4128388</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128388</idno><idno type="RBID">PMC:4128388</idno><idno type="doi">10.1038/ni.2649</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001D75</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D75</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Anti-apoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3<sup>+</sup> regulatory T cells</title><author><name sortKey="Pierson, Wim" sort="Pierson, Wim" uniqKey="Pierson W" first="Wim" last="Pierson">Wim Pierson</name><affiliation><nlm:aff id="A1">Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Cauwe, Benedicte" sort="Cauwe, Benedicte" uniqKey="Cauwe B" first="Bénédicte" last="Cauwe">Bénédicte Cauwe</name><affiliation><nlm:aff id="A1">Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Policheni, Antonia" sort="Policheni, Antonia" uniqKey="Policheni A" first="Antonia" last="Policheni">Antonia Policheni</name><affiliation><nlm:aff id="A3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Medical Biology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Schlenner, Susan M" sort="Schlenner, Susan M" uniqKey="Schlenner S" first="Susan M." last="Schlenner">Susan M. Schlenner</name><affiliation><nlm:aff id="A1">Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Franckaert, Dean" sort="Franckaert, Dean" uniqKey="Franckaert D" first="Dean" last="Franckaert">Dean Franckaert</name><affiliation><nlm:aff id="A1">Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Berges, Julien" sort="Berges, Julien" uniqKey="Berges J" first="Julien" last="Berges">Julien Berges</name><affiliation><nlm:aff id="A5">Unité de Biologie des Populations Lymphocytaires, Department of Immunology, Institut Pasteur, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Centre national de la recherché scientifique, URA 1961, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Humblet Baron, Stephanie" sort="Humblet Baron, Stephanie" uniqKey="Humblet Baron S" first="Stephanie" last="Humblet-Baron">Stephanie Humblet-Baron</name><affiliation><nlm:aff id="A1">Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Schonefeldt, Susann" sort="Schonefeldt, Susann" uniqKey="Schonefeldt S" first="Susann" last="Schonefeldt">Susann Schonefeldt</name><affiliation><nlm:aff id="A1">Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Herold, Marco J" sort="Herold, Marco J" uniqKey="Herold M" first="Marco J." last="Herold">Marco J. Herold</name><affiliation><nlm:aff id="A3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Medical Biology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Hildeman, David" sort="Hildeman, David" uniqKey="Hildeman D" first="David" last="Hildeman">David Hildeman</name><affiliation><nlm:aff id="A7">Division of Immunobiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Children’s Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff></affiliation></author><author><name sortKey="Strasser, Andreas" sort="Strasser, Andreas" uniqKey="Strasser A" first="Andreas" last="Strasser">Andreas Strasser</name><affiliation><nlm:aff id="A3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Medical Biology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Bouillet, Philippe" sort="Bouillet, Philippe" uniqKey="Bouillet P" first="Philippe" last="Bouillet">Philippe Bouillet</name><affiliation><nlm:aff id="A3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Medical Biology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Lu, Li Fan" sort="Lu, Li Fan" uniqKey="Lu L" first="Li-Fan" last="Lu">Li-Fan Lu</name><affiliation><nlm:aff id="A9">Section of Molecular Biology, Division of Biological Sciences, University of California–San Diego, La Jolla, California, USA</nlm:aff></affiliation></author><author><name sortKey="Matthys, Patrick" sort="Matthys, Patrick" uniqKey="Matthys P" first="Patrick" last="Matthys">Patrick Matthys</name><affiliation><nlm:aff id="A10">Laboratory of Immunobiology, Rega Institute, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Freitas, Antonio A" sort="Freitas, Antonio A" uniqKey="Freitas A" first="Antonio A." last="Freitas">Antonio A. Freitas</name><affiliation><nlm:aff id="A5">Unité de Biologie des Populations Lymphocytaires, Department of Immunology, Institut Pasteur, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Centre national de la recherché scientifique, URA 1961, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Luther, Rita J" sort="Luther, Rita J" uniqKey="Luther R" first="Rita J." last="Luther">Rita J. Luther</name><affiliation><nlm:aff id="A11">Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA</nlm:aff></affiliation></author><author><name sortKey="Weaver, Casey T" sort="Weaver, Casey T" uniqKey="Weaver C" first="Casey T." last="Weaver">Casey T. Weaver</name><affiliation><nlm:aff id="A11">Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA</nlm:aff></affiliation></author><author><name sortKey="Dooley, James" sort="Dooley, James" uniqKey="Dooley J" first="James" last="Dooley">James Dooley</name><affiliation><nlm:aff id="A1">Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Gray, Daniel H D" sort="Gray, Daniel H D" uniqKey="Gray D" first="Daniel H. D." last="Gray">Daniel H. D. Gray</name><affiliation><nlm:aff id="A3">The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Medical Biology, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Liston, Adrian" sort="Liston, Adrian" uniqKey="Liston A" first="Adrian" last="Liston">Adrian Liston</name><affiliation><nlm:aff id="A1">Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author></analytic><series><title level="j">Nature immunology</title><idno type="ISSN">1529-2908</idno><idno type="eISSN">1529-2916</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Foxp3<sup>+</sup> regulatory T (T<sub>reg</sub>) cells are a crucial immunosuppressive population of CD4<sup>+</sup> T cells, yet the homeostatic processes and survival programs that maintain the T<sub>reg</sub> cell pool are poorly understood. Here we report that peripheral T<sub>reg</sub> cells markedly alter their proliferative and apoptotic rates to rapidly restore numerical deficit through an interleukin 2–dependent and costimulation-dependent process. By contrast, excess T<sub>reg</sub> cells are removed by attrition, dependent on the Bim-initiated Bak- and Bax-dependent intrinsic apoptotic pathway. The antiapoptotic proteins Bcl-x<sub>L</sub> and Bcl-2 were dispensable for survival of T<sub>reg</sub> cells, whereas Mcl-1 was critical for survival of T<sub>reg</sub> cells, and the loss of this antiapoptotic protein caused fatal autoimmunity. Together, these data define the active processes by which T<sub>reg</sub> cells maintain homeostasis via critical survival pathways.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100941354</journal-id><journal-id journal-id-type="pubmed-jr-id">21750</journal-id><journal-id journal-id-type="nlm-ta">Nat Immunol</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Immunol.</journal-id><journal-title-group><journal-title>Nature immunology</journal-title></journal-title-group><issn pub-type="ppub">1529-2908</issn><issn pub-type="epub">1529-2916</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23852275</article-id><article-id pub-id-type="pmc">4128388</article-id><article-id pub-id-type="doi">10.1038/ni.2649</article-id><article-id pub-id-type="manuscript">NIHMS608202</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Anti-apoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3<sup>+</sup> regulatory T cells</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Pierson</surname><given-names>Wim</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Cauwe</surname><given-names>Bénédicte</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Policheni</surname><given-names>Antonia</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Schlenner</surname><given-names>Susan M.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Franckaert</surname><given-names>Dean</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Berges</surname><given-names>Julien</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Humblet-Baron</surname><given-names>Stephanie</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Schonefeldt</surname><given-names>Susann</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Herold</surname><given-names>Marco J.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Hildeman</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Strasser</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Bouillet</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>Li-Fan</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Matthys</surname><given-names>Patrick</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Freitas</surname><given-names>Antonio A.</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Luther</surname><given-names>Rita J.</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Weaver</surname><given-names>Casey T.</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Dooley</surname><given-names>James</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Gray</surname><given-names>Daniel H. D.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Liston</surname><given-names>Adrian</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Autoimmune Genetics Laboratory, VIB, Leuven, Belgium</aff><aff id="A2"><label>2</label>Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium</aff><aff id="A3"><label>3</label>The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia</aff><aff id="A4"><label>4</label>Department of Medical Biology, University of Melbourne, Melbourne, Australia</aff><aff id="A5"><label>5</label>Unité de Biologie des Populations Lymphocytaires, Department of Immunology, Institut Pasteur, Paris, France</aff><aff id="A6"><label>6</label>Centre national de la recherché scientifique, URA 1961, Paris, France</aff><aff id="A7"><label>7</label>Division of Immunobiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA</aff><aff id="A8"><label>8</label>Children’s Hospital Medical Center, Cincinnati, Ohio, USA</aff><aff id="A9"><label>9</label>Section of Molecular Biology, Division of Biological Sciences, University of California–San Diego, La Jolla, California, USA</aff><aff id="A10"><label>10</label>Laboratory of Immunobiology, Rega Institute, University of Leuven, Leuven, Belgium</aff><aff id="A11"><label>11</label>Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA</aff><author-notes><corresp id="FN1">Correspondence should be addressed to A.L. (<email>adrian.liston@vib.be</email>) or D.H.D.G. (<email>dgray@wehi.edu.au</email>)</corresp><fn id="FN2" fn-type="equal"><label>*</label><p>These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>25</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>14</day><month>7</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>11</day><month>8</month><year>2014</year></pub-date><volume>14</volume><issue>9</issue><fpage>959</fpage><lpage>965</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ni.2649</pmc-comment>
<abstract><p id="P1">Foxp3<sup>+</sup> regulatory T (T<sub>reg</sub>) cells are a crucial immunosuppressive population of CD4<sup>+</sup> T cells, yet the homeostatic processes and survival programs that maintain the T<sub>reg</sub> cell pool are poorly understood. Here we report that peripheral T<sub>reg</sub> cells markedly alter their proliferative and apoptotic rates to rapidly restore numerical deficit through an interleukin 2–dependent and costimulation-dependent process. By contrast, excess T<sub>reg</sub> cells are removed by attrition, dependent on the Bim-initiated Bak- and Bax-dependent intrinsic apoptotic pathway. The antiapoptotic proteins Bcl-x<sub>L</sub> and Bcl-2 were dispensable for survival of T<sub>reg</sub> cells, whereas Mcl-1 was critical for survival of T<sub>reg</sub> cells, and the loss of this antiapoptotic protein caused fatal autoimmunity. Together, these data define the active processes by which T<sub>reg</sub> cells maintain homeostasis via critical survival pathways.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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| This area was generated with Dilib version V0.6.33. |  |