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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Is the adiposity-associated <italic>FTO</italic> gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults</title><author><name sortKey="Zimmermann, E" sort="Zimmermann, E" uniqKey="Zimmermann E" first="E." last="Zimmermann">E. Zimmermann</name><affiliation><nlm:aff id="A1">Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey=" Ngquist, L H" sort=" Ngquist, L H" uniqKey=" Ngquist L" first="L. H." last=" Ngquist">L. H. Ngquist</name><affiliation><nlm:aff id="A1">Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Mirza, S S" sort="Mirza, S S" uniqKey="Mirza S" first="S. S." last="Mirza">S. S. Mirza</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Zhao, J H" sort="Zhao, J H" uniqKey="Zhao J" first="J. H." last="Zhao">J. H. Zhao</name><affiliation><nlm:aff id="A3">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chasman, D I" sort="Chasman, D I" uniqKey="Chasman D" first="D. I." last="Chasman">D. I. Chasman</name><affiliation><nlm:aff id="A4">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Fischer, K" sort="Fischer, K" uniqKey="Fischer K" first="K." last="Fischer">K. Fischer</name><affiliation><nlm:aff id="A6">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Qi, Q" sort="Qi, Q" uniqKey="Qi Q" first="Q." last="Qi">Q. Qi</name><affiliation><nlm:aff id="A7">Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, A V" sort="Smith, A V" uniqKey="Smith A" first="A. V." last="Smith">A. V. Smith</name><affiliation><nlm:aff id="A8">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A9">University of Icelandic, Reykajvik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Thinggaard, M" sort="Thinggaard, M" uniqKey="Thinggaard M" first="M." last="Thinggaard">M. Thinggaard</name><affiliation><nlm:aff id="A10">The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Jarczok, M N" sort="Jarczok, M N" uniqKey="Jarczok M" first="M. N." last="Jarczok">M. N. Jarczok</name><affiliation><nlm:aff id="A11">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Nalls, M A" sort="Nalls, M A" uniqKey="Nalls M" first="M. A." last="Nalls">M. A. Nalls</name><affiliation><nlm:aff id="A12">Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Trompet, S" sort="Trompet, S" uniqKey="Trompet S" first="S." last="Trompet">S. Trompet</name><affiliation><nlm:aff id="A13">Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Timpson, N J" sort="Timpson, N J" uniqKey="Timpson N" first="N. J." last="Timpson">N. J. Timpson</name><affiliation><nlm:aff id="A15">MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Schmidt, B" sort="Schmidt, B" uniqKey="Schmidt B" first="B." last="Schmidt">B. Schmidt</name><affiliation><nlm:aff id="A16">Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Jackson, A U" sort="Jackson, A U" uniqKey="Jackson A" first="A. U." last="Jackson">A. U. Jackson</name><affiliation><nlm:aff id="A17">Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Lyytik Inen, L P" sort="Lyytik Inen, L P" uniqKey="Lyytik Inen L" first="L. P." last="Lyytik Inen">L. P. Lyytik Inen</name><affiliation><nlm:aff id="A18">Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A19">School of Medicine, University of Tampere, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Verweij, N" sort="Verweij, N" uniqKey="Verweij N" first="N." last="Verweij">N. Verweij</name><affiliation><nlm:aff id="A20">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mueller Nurasyid, M" sort="Mueller Nurasyid, M" uniqKey="Mueller Nurasyid M" first="M." last="Mueller-Nurasyid">M. Mueller-Nurasyid</name><affiliation><nlm:aff id="A21">Department of Medicine I, Ludwig-Maximilians-University, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Institute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK), Partner site Munich Heart Alliance, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Vikstrom, M" sort="Vikstrom, M" uniqKey="Vikstrom M" first="M." last="Vikström">M. Vikström</name><affiliation><nlm:aff id="A25">Karolinska Institutet, Institute of Environmental Medicine, Unit of Cardiovascular Epidemiology, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Marques Vidal, P" sort="Marques Vidal, P" uniqKey="Marques Vidal P" first="P." last="Marques-Vidal">P. Marques-Vidal</name><affiliation><nlm:aff id="A26">Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wong, A" sort="Wong, A" uniqKey="Wong A" first="A." last="Wong">A. Wong</name><affiliation><nlm:aff id="A27">MRC Unit for Lifelong Health and Ageing, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Meidtner, K" sort="Meidtner, K" uniqKey="Meidtner K" first="K." last="Meidtner">K. Meidtner</name><affiliation><nlm:aff id="A28">Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany</nlm:aff></affiliation></author><author><name sortKey="Middelberg, R P" sort="Middelberg, R P" uniqKey="Middelberg R" first="R. P." last="Middelberg">R. P. Middelberg</name><affiliation><nlm:aff id="A30">QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Strawbridge, R J" sort="Strawbridge, R J" uniqKey="Strawbridge R" first="R. J." last="Strawbridge">R. J. Strawbridge</name><affiliation><nlm:aff id="A31">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Christiansen, L" sort="Christiansen, L" uniqKey="Christiansen L" first="L." last="Christiansen">L. Christiansen</name><affiliation><nlm:aff id="A10">The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Kyvik, K O" sort="Kyvik, K O" uniqKey="Kyvik K" first="K. O." last="Kyvik">K. O. Kyvik</name><affiliation><nlm:aff id="A32">Institute of Regional Health Services Research and Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hamsten, A" sort="Hamsten, A" uniqKey="Hamsten A" first="A." last="Hamsten">A. Hamsten</name><affiliation><nlm:aff id="A31">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="J Skel Inen, T" sort="J Skel Inen, T" uniqKey="J Skel Inen T" first="T." last="J Skel Inen">T. J Skel Inen</name><affiliation><nlm:aff id="A33">Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Tj Nneland, A" sort="Tj Nneland, A" uniqKey="Tj Nneland A" first="A." last="Tj Nneland">A. Tj Nneland</name><affiliation><nlm:aff id="A34">Danish Cancer Society Research Centre, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Eriksson, J G" sort="Eriksson, J G" uniqKey="Eriksson J" first="J. G." last="Eriksson">J. G. Eriksson</name><affiliation><nlm:aff id="A35">Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Department of General Practice and Primary Health Care, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Folkhälsan Research Centre, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Whitfield, J B" sort="Whitfield, J B" uniqKey="Whitfield J" first="J. B." last="Whitfield">J. B. Whitfield</name><affiliation><nlm:aff id="A30">QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Boeing, H" sort="Boeing, H" uniqKey="Boeing H" first="H." last="Boeing">H. Boeing</name><affiliation><nlm:aff id="A29">Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany</nlm:aff></affiliation></author><author><name sortKey="Hardy, R" sort="Hardy, R" uniqKey="Hardy R" first="R." last="Hardy">R. Hardy</name><affiliation><nlm:aff id="A27">MRC Unit for Lifelong Health and Ageing, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, P" sort="Vollenweider, P" uniqKey="Vollenweider P" first="P." last="Vollenweider">P. Vollenweider</name><affiliation><nlm:aff id="A26">Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Leander, K" sort="Leander, K" uniqKey="Leander K" first="K." last="Leander">K. Leander</name><affiliation><nlm:aff id="A25">Karolinska Institutet, Institute of Environmental Medicine, Unit of Cardiovascular Epidemiology, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Peters, A" sort="Peters, A" uniqKey="Peters A" first="A." last="Peters">A. Peters</name><affiliation><nlm:aff id="A24">Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK), Partner site Munich Heart Alliance, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Van Der Harst, P" sort="Van Der Harst, P" uniqKey="Van Der Harst P" first="P." last="Van Der Harst">P. Van Der Harst</name><affiliation><nlm:aff id="A20">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Department of Genetic, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Durrer Center for Cardiogenetic Research, ICIN-Neterlands Heart Institute, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kumari, M" sort="Kumari, M" uniqKey="Kumari M" first="M." last="Kumari">M. Kumari</name><affiliation><nlm:aff id="A42">Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A43">ISER, University of Essex, Colchester, UK</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, T" sort="Lehtim Ki, T" uniqKey="Lehtim Ki T" first="T." last="Lehtim Ki">T. Lehtim Ki</name><affiliation><nlm:aff id="A18">Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A19">School of Medicine, University of Tampere, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Meirhaeghe, A" sort="Meirhaeghe, A" uniqKey="Meirhaeghe A" first="A." last="Meirhaeghe">A. Meirhaeghe</name><affiliation><nlm:aff id="A44">Inserm, U744, Institut Pasteur de Lille, University Lille Nord de France, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, J" sort="Tuomilehto, J" uniqKey="Tuomilehto J" first="J." last="Tuomilehto">J. Tuomilehto</name><affiliation><nlm:aff id="A45">Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A46">Centre for Vascular Prevention, Danube-University Krems, Krems, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Jockel, K H" sort="Jockel, K H" uniqKey="Jockel K" first="K.-H." last="Jöckel">K.-H. Jöckel</name><affiliation><nlm:aff id="A16">Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ben Shlomo, Y" sort="Ben Shlomo, Y" uniqKey="Ben Shlomo Y" first="Y." last="Ben-Shlomo">Y. Ben-Shlomo</name><affiliation><nlm:aff id="A49">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Sattar, N" sort="Sattar, N" uniqKey="Sattar N" first="N." last="Sattar">N. Sattar</name><affiliation><nlm:aff id="A50">BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Baumeister, S E" sort="Baumeister, S E" uniqKey="Baumeister S" first="S. E." last="Baumeister">S. E. Baumeister</name><affiliation><nlm:aff id="A51">Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Smith, G Davey" sort="Smith, G Davey" uniqKey="Smith G" first="G. Davey" last="Smith">G. Davey Smith</name><affiliation><nlm:aff id="A15">MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Casas, J P" sort="Casas, J P" uniqKey="Casas J" first="J. P." last="Casas">J. P. Casas</name><affiliation><nlm:aff id="A52">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Institute of Cardiovascular Science, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Houston, D K" sort="Houston, D K" uniqKey="Houston D" first="D. K." last="Houston">D. K. Houston</name><affiliation><nlm:aff id="A54">Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="M Rz, W" sort="M Rz, W" uniqKey="M Rz W" first="W." last="M Rz">W. M Rz</name><affiliation><nlm:aff id="A55">Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Synlab Academy, Synlab Services GmbH, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Christensen, K" sort="Christensen, K" uniqKey="Christensen K" first="K." last="Christensen">K. Christensen</name><affiliation><nlm:aff id="A10">The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Gudnason, V" sort="Gudnason, V" uniqKey="Gudnason V" first="V." last="Gudnason">V. Gudnason</name><affiliation><nlm:aff id="A8">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A9">University of Icelandic, Reykajvik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Hu, F B" sort="Hu, F B" uniqKey="Hu F" first="F. B." last="Hu">F. B. Hu</name><affiliation><nlm:aff id="A60">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Metspalu, A" sort="Metspalu, A" uniqKey="Metspalu A" first="A." last="Metspalu">A. Metspalu</name><affiliation><nlm:aff id="A6">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Ridker, P M" sort="Ridker, P M" uniqKey="Ridker P" first="P. M." last="Ridker">P. M. Ridker</name><affiliation><nlm:aff id="A4">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Wareham, N J" sort="Wareham, N J" uniqKey="Wareham N" first="N. J." last="Wareham">N. J. Wareham</name><affiliation><nlm:aff id="A3">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Loos, R J F" sort="Loos, R J F" uniqKey="Loos R" first="R. J. F." last="Loos">R. J. F. Loos</name><affiliation><nlm:aff id="A3">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A62">The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Tiemeier, H" sort="Tiemeier, H" uniqKey="Tiemeier H" first="H." last="Tiemeier">H. Tiemeier</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Department of Child and Adolescent Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sonestedt, E" sort="Sonestedt, E" uniqKey="Sonestedt E" first="E." last="Sonestedt">E. Sonestedt</name><affiliation><nlm:aff id="A65">Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="S Rensen, T I A" sort="S Rensen, T I A" uniqKey="S Rensen T" first="T. I. A." last="S Rensen">T. I. A. S Rensen</name><affiliation><nlm:aff id="A1">Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A15">MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Novo Nordisk Foundation Centre for Basic Metabolic Research, Section on Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25752329</idno><idno type="pmc">4564522</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564522</idno><idno type="RBID">PMC:4564522</idno><idno type="doi">10.1111/obr.12263</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001D72</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Is the adiposity-associated <italic>FTO</italic> gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults</title><author><name sortKey="Zimmermann, E" sort="Zimmermann, E" uniqKey="Zimmermann E" first="E." last="Zimmermann">E. Zimmermann</name><affiliation><nlm:aff id="A1">Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey=" Ngquist, L H" sort=" Ngquist, L H" uniqKey=" Ngquist L" first="L. H." last=" Ngquist">L. H. Ngquist</name><affiliation><nlm:aff id="A1">Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Mirza, S S" sort="Mirza, S S" uniqKey="Mirza S" first="S. S." last="Mirza">S. S. Mirza</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Zhao, J H" sort="Zhao, J H" uniqKey="Zhao J" first="J. H." last="Zhao">J. H. Zhao</name><affiliation><nlm:aff id="A3">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chasman, D I" sort="Chasman, D I" uniqKey="Chasman D" first="D. I." last="Chasman">D. I. Chasman</name><affiliation><nlm:aff id="A4">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Fischer, K" sort="Fischer, K" uniqKey="Fischer K" first="K." last="Fischer">K. Fischer</name><affiliation><nlm:aff id="A6">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Qi, Q" sort="Qi, Q" uniqKey="Qi Q" first="Q." last="Qi">Q. Qi</name><affiliation><nlm:aff id="A7">Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, A V" sort="Smith, A V" uniqKey="Smith A" first="A. V." last="Smith">A. V. Smith</name><affiliation><nlm:aff id="A8">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A9">University of Icelandic, Reykajvik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Thinggaard, M" sort="Thinggaard, M" uniqKey="Thinggaard M" first="M." last="Thinggaard">M. Thinggaard</name><affiliation><nlm:aff id="A10">The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Jarczok, M N" sort="Jarczok, M N" uniqKey="Jarczok M" first="M. N." last="Jarczok">M. N. Jarczok</name><affiliation><nlm:aff id="A11">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Nalls, M A" sort="Nalls, M A" uniqKey="Nalls M" first="M. A." last="Nalls">M. A. Nalls</name><affiliation><nlm:aff id="A12">Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Trompet, S" sort="Trompet, S" uniqKey="Trompet S" first="S." last="Trompet">S. Trompet</name><affiliation><nlm:aff id="A13">Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Timpson, N J" sort="Timpson, N J" uniqKey="Timpson N" first="N. J." last="Timpson">N. J. Timpson</name><affiliation><nlm:aff id="A15">MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Schmidt, B" sort="Schmidt, B" uniqKey="Schmidt B" first="B." last="Schmidt">B. Schmidt</name><affiliation><nlm:aff id="A16">Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Jackson, A U" sort="Jackson, A U" uniqKey="Jackson A" first="A. U." last="Jackson">A. U. Jackson</name><affiliation><nlm:aff id="A17">Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Lyytik Inen, L P" sort="Lyytik Inen, L P" uniqKey="Lyytik Inen L" first="L. P." last="Lyytik Inen">L. P. Lyytik Inen</name><affiliation><nlm:aff id="A18">Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A19">School of Medicine, University of Tampere, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Verweij, N" sort="Verweij, N" uniqKey="Verweij N" first="N." last="Verweij">N. Verweij</name><affiliation><nlm:aff id="A20">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mueller Nurasyid, M" sort="Mueller Nurasyid, M" uniqKey="Mueller Nurasyid M" first="M." last="Mueller-Nurasyid">M. Mueller-Nurasyid</name><affiliation><nlm:aff id="A21">Department of Medicine I, Ludwig-Maximilians-University, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Institute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK), Partner site Munich Heart Alliance, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Vikstrom, M" sort="Vikstrom, M" uniqKey="Vikstrom M" first="M." last="Vikström">M. Vikström</name><affiliation><nlm:aff id="A25">Karolinska Institutet, Institute of Environmental Medicine, Unit of Cardiovascular Epidemiology, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Marques Vidal, P" sort="Marques Vidal, P" uniqKey="Marques Vidal P" first="P." last="Marques-Vidal">P. Marques-Vidal</name><affiliation><nlm:aff id="A26">Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wong, A" sort="Wong, A" uniqKey="Wong A" first="A." last="Wong">A. Wong</name><affiliation><nlm:aff id="A27">MRC Unit for Lifelong Health and Ageing, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Meidtner, K" sort="Meidtner, K" uniqKey="Meidtner K" first="K." last="Meidtner">K. Meidtner</name><affiliation><nlm:aff id="A28">Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany</nlm:aff></affiliation></author><author><name sortKey="Middelberg, R P" sort="Middelberg, R P" uniqKey="Middelberg R" first="R. P." last="Middelberg">R. P. Middelberg</name><affiliation><nlm:aff id="A30">QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Strawbridge, R J" sort="Strawbridge, R J" uniqKey="Strawbridge R" first="R. J." last="Strawbridge">R. J. Strawbridge</name><affiliation><nlm:aff id="A31">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Christiansen, L" sort="Christiansen, L" uniqKey="Christiansen L" first="L." last="Christiansen">L. Christiansen</name><affiliation><nlm:aff id="A10">The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Kyvik, K O" sort="Kyvik, K O" uniqKey="Kyvik K" first="K. O." last="Kyvik">K. O. Kyvik</name><affiliation><nlm:aff id="A32">Institute of Regional Health Services Research and Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Hamsten, A" sort="Hamsten, A" uniqKey="Hamsten A" first="A." last="Hamsten">A. Hamsten</name><affiliation><nlm:aff id="A31">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="J Skel Inen, T" sort="J Skel Inen, T" uniqKey="J Skel Inen T" first="T." last="J Skel Inen">T. J Skel Inen</name><affiliation><nlm:aff id="A33">Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Tj Nneland, A" sort="Tj Nneland, A" uniqKey="Tj Nneland A" first="A." last="Tj Nneland">A. Tj Nneland</name><affiliation><nlm:aff id="A34">Danish Cancer Society Research Centre, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Eriksson, J G" sort="Eriksson, J G" uniqKey="Eriksson J" first="J. G." last="Eriksson">J. G. Eriksson</name><affiliation><nlm:aff id="A35">Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Department of General Practice and Primary Health Care, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Folkhälsan Research Centre, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Whitfield, J B" sort="Whitfield, J B" uniqKey="Whitfield J" first="J. B." last="Whitfield">J. B. Whitfield</name><affiliation><nlm:aff id="A30">QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Boeing, H" sort="Boeing, H" uniqKey="Boeing H" first="H." last="Boeing">H. Boeing</name><affiliation><nlm:aff id="A29">Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany</nlm:aff></affiliation></author><author><name sortKey="Hardy, R" sort="Hardy, R" uniqKey="Hardy R" first="R." last="Hardy">R. Hardy</name><affiliation><nlm:aff id="A27">MRC Unit for Lifelong Health and Ageing, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, P" sort="Vollenweider, P" uniqKey="Vollenweider P" first="P." last="Vollenweider">P. Vollenweider</name><affiliation><nlm:aff id="A26">Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Leander, K" sort="Leander, K" uniqKey="Leander K" first="K." last="Leander">K. Leander</name><affiliation><nlm:aff id="A25">Karolinska Institutet, Institute of Environmental Medicine, Unit of Cardiovascular Epidemiology, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Peters, A" sort="Peters, A" uniqKey="Peters A" first="A." last="Peters">A. Peters</name><affiliation><nlm:aff id="A24">Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK), Partner site Munich Heart Alliance, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Van Der Harst, P" sort="Van Der Harst, P" uniqKey="Van Der Harst P" first="P." last="Van Der Harst">P. Van Der Harst</name><affiliation><nlm:aff id="A20">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Department of Genetic, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Durrer Center for Cardiogenetic Research, ICIN-Neterlands Heart Institute, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kumari, M" sort="Kumari, M" uniqKey="Kumari M" first="M." last="Kumari">M. Kumari</name><affiliation><nlm:aff id="A42">Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A43">ISER, University of Essex, Colchester, UK</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, T" sort="Lehtim Ki, T" uniqKey="Lehtim Ki T" first="T." last="Lehtim Ki">T. Lehtim Ki</name><affiliation><nlm:aff id="A18">Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A19">School of Medicine, University of Tampere, Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Meirhaeghe, A" sort="Meirhaeghe, A" uniqKey="Meirhaeghe A" first="A." last="Meirhaeghe">A. Meirhaeghe</name><affiliation><nlm:aff id="A44">Inserm, U744, Institut Pasteur de Lille, University Lille Nord de France, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Tuomilehto, J" sort="Tuomilehto, J" uniqKey="Tuomilehto J" first="J." last="Tuomilehto">J. Tuomilehto</name><affiliation><nlm:aff id="A45">Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A46">Centre for Vascular Prevention, Danube-University Krems, Krems, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Jockel, K H" sort="Jockel, K H" uniqKey="Jockel K" first="K.-H." last="Jöckel">K.-H. Jöckel</name><affiliation><nlm:aff id="A16">Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany</nlm:aff></affiliation></author><author><name sortKey="Ben Shlomo, Y" sort="Ben Shlomo, Y" uniqKey="Ben Shlomo Y" first="Y." last="Ben-Shlomo">Y. Ben-Shlomo</name><affiliation><nlm:aff id="A49">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Sattar, N" sort="Sattar, N" uniqKey="Sattar N" first="N." last="Sattar">N. Sattar</name><affiliation><nlm:aff id="A50">BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Baumeister, S E" sort="Baumeister, S E" uniqKey="Baumeister S" first="S. E." last="Baumeister">S. E. Baumeister</name><affiliation><nlm:aff id="A51">Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Smith, G Davey" sort="Smith, G Davey" uniqKey="Smith G" first="G. Davey" last="Smith">G. Davey Smith</name><affiliation><nlm:aff id="A15">MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Casas, J P" sort="Casas, J P" uniqKey="Casas J" first="J. P." last="Casas">J. P. Casas</name><affiliation><nlm:aff id="A52">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Institute of Cardiovascular Science, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Houston, D K" sort="Houston, D K" uniqKey="Houston D" first="D. K." last="Houston">D. K. Houston</name><affiliation><nlm:aff id="A54">Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="M Rz, W" sort="M Rz, W" uniqKey="M Rz W" first="W." last="M Rz">W. M Rz</name><affiliation><nlm:aff id="A55">Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Synlab Academy, Synlab Services GmbH, Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Christensen, K" sort="Christensen, K" uniqKey="Christensen K" first="K." last="Christensen">K. Christensen</name><affiliation><nlm:aff id="A10">The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark</nlm:aff></affiliation></author><author><name sortKey="Gudnason, V" sort="Gudnason, V" uniqKey="Gudnason V" first="V." last="Gudnason">V. Gudnason</name><affiliation><nlm:aff id="A8">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A9">University of Icelandic, Reykajvik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Hu, F B" sort="Hu, F B" uniqKey="Hu F" first="F. B." last="Hu">F. B. Hu</name><affiliation><nlm:aff id="A60">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Metspalu, A" sort="Metspalu, A" uniqKey="Metspalu A" first="A." last="Metspalu">A. Metspalu</name><affiliation><nlm:aff id="A6">Estonian Genome Center, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Ridker, P M" sort="Ridker, P M" uniqKey="Ridker P" first="P. M." last="Ridker">P. M. Ridker</name><affiliation><nlm:aff id="A4">Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Wareham, N J" sort="Wareham, N J" uniqKey="Wareham N" first="N. J." last="Wareham">N. J. Wareham</name><affiliation><nlm:aff id="A3">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Loos, R J F" sort="Loos, R J F" uniqKey="Loos R" first="R. J. F." last="Loos">R. J. F. Loos</name><affiliation><nlm:aff id="A3">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A62">The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Tiemeier, H" sort="Tiemeier, H" uniqKey="Tiemeier H" first="H." last="Tiemeier">H. Tiemeier</name><affiliation><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Department of Child and Adolescent Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sonestedt, E" sort="Sonestedt, E" uniqKey="Sonestedt E" first="E." last="Sonestedt">E. Sonestedt</name><affiliation><nlm:aff id="A65">Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="S Rensen, T I A" sort="S Rensen, T I A" uniqKey="S Rensen T" first="T. I. A." last="S Rensen">T. I. A. S Rensen</name><affiliation><nlm:aff id="A1">Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A15">MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Novo Nordisk Foundation Centre for Basic Metabolic Research, Section on Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark</nlm:aff></affiliation></author></analytic><series><title level="j">Obesity reviews : an official journal of the International Association for the Study of Obesity</title><idno type="ISSN">1467-7881</idno><idno type="eISSN">1467-789X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p id="P3">Previously, a single nucleotide polymorphism (SNP), rs9939609, in the <italic>FTO</italic> gene showed a much stronger association with all-cause mortality than expected from its association with body mass index (BMI), body fat mass index (FMI) and waist circumference (WC). This finding implies that the SNP has strong pleiotropic effects on adiposity and adiposity-independent pathological pathways that leads to increased mortality. To investigate this further, we conducted a meta-analysis of similar data from 34 longitudinal studies including 169,551 adult Caucasians among whom 27,100 died during follow-up. Linear regression showed that the minor allele of the <italic>FTO</italic> SNP was associated with greater BMI (<italic>n</italic> = 169,551; 0.32 kg m<sup>−2</sup>; 95% CI 0.28–0.32, <italic>P</italic> < 1 × 10<sup>−32</sup>), WC (<italic>n</italic> = 152,631; 0.76 cm; 0.68–0.84, <italic>P</italic> < 1 × 10<sup>−32</sup>) and FMI (<italic>n</italic> = 48,192; 0.17 kg m<sup>−2</sup>; 0.13–0.22, <italic>P</italic> = 1.0 × 10<sup>−13</sup>). Cox proportional hazard regression analyses for mortality showed that the hazards ratio (HR) for the minor allele of the <italic>FTO</italic> SNPs was 1.02 (1.00–1.04, <italic>P</italic> = 0.097), but the apparent excess risk was eliminated after adjustment for BMI and WC (HR: 1.00; 0.98–1.03, <italic>P</italic> = 0.662) and for FMI (HR: 1.00; 0.96–1.04, <italic>P</italic> = 0.932). In conclusion, this study does not support that the <italic>FTO</italic> SNP is associated with all-cause mortality independently of the adiposity phenotypes.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100897395</journal-id><journal-id journal-id-type="pubmed-jr-id">29765</journal-id><journal-id journal-id-type="nlm-ta">Obes Rev</journal-id><journal-id journal-id-type="iso-abbrev">Obes Rev</journal-id><journal-title-group><journal-title>Obesity reviews : an official journal of the International Association for the Study of Obesity</journal-title></journal-title-group><issn pub-type="ppub">1467-7881</issn><issn pub-type="epub">1467-789X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25752329</article-id><article-id pub-id-type="pmc">4564522</article-id><article-id pub-id-type="doi">10.1111/obr.12263</article-id><article-id pub-id-type="manuscript">NIHMS710887</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Is the adiposity-associated <italic>FTO</italic> gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Zimmermann</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Ängquist</surname><given-names>L. H.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mirza</surname><given-names>S. S.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>J. H.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Chasman</surname><given-names>D. I.</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Fischer</surname><given-names>K.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Qi</surname><given-names>Q.</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>A. V.</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Thinggaard</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Jarczok</surname><given-names>M. N.</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Nalls</surname><given-names>M. A.</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Trompet</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Timpson</surname><given-names>N. J.</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>B.</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Jackson</surname><given-names>A. U.</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Lyytikäinen</surname><given-names>L. P.</given-names></name><xref ref-type="aff" rid="A18">18</xref><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Verweij</surname><given-names>N.</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Mueller-Nurasyid</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="A21">21</xref><xref ref-type="aff" rid="A22">22</xref><xref ref-type="aff" rid="A23">23</xref><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Vikström</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Marques-Vidal</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Wong</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Meidtner</surname><given-names>K.</given-names></name><xref ref-type="aff" rid="A28">28</xref><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Middelberg</surname><given-names>R. P.</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Strawbridge</surname><given-names>R. J.</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Christiansen</surname><given-names>L.</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><collab>The FTO-Mortality Collaborating Group</collab></contrib><contrib contrib-type="author"><name><surname>Kyvik</surname><given-names>K. O.</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Hamsten</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Jääskeläinen</surname><given-names>T.</given-names></name><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Tjønneland</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Eriksson</surname><given-names>J. G.</given-names></name><xref ref-type="aff" rid="A35">35</xref><xref ref-type="aff" rid="A36">36</xref><xref ref-type="aff" rid="A37">37</xref><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Whitfield</surname><given-names>J. B.</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Boeing</surname><given-names>H.</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Hardy</surname><given-names>R.</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Vollenweider</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Leander</surname><given-names>K.</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Peters</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="A24">24</xref><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>van der Harst</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="A20">20</xref><xref ref-type="aff" rid="A40">40</xref><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Kumari</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="A42">42</xref><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Lehtimäki</surname><given-names>T.</given-names></name><xref ref-type="aff" rid="A18">18</xref><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Meirhaeghe</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Tuomilehto</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="A45">45</xref><xref ref-type="aff" rid="A46">46</xref><xref ref-type="aff" rid="A47">47</xref><xref ref-type="aff" rid="A48">48</xref></contrib><contrib contrib-type="author"><name><surname>Jöckel</surname><given-names>K.-H.</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Ben-Shlomo</surname><given-names>Y.</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Sattar</surname><given-names>N.</given-names></name><xref ref-type="aff" rid="A50">50</xref></contrib><contrib contrib-type="author"><name><surname>Baumeister</surname><given-names>S. E.</given-names></name><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>G. Davey</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Casas</surname><given-names>J. P.</given-names></name><xref ref-type="aff" rid="A52">52</xref><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Houston</surname><given-names>D. K.</given-names></name><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>März</surname><given-names>W.</given-names></name><xref ref-type="aff" rid="A55">55</xref><xref ref-type="aff" rid="A56">56</xref><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Christensen</surname><given-names>K.</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A58">58</xref><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Gudnason</surname><given-names>V.</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Hu</surname><given-names>F. B.</given-names></name><xref ref-type="aff" rid="A60">60</xref><xref ref-type="aff" rid="A61">61</xref></contrib><contrib contrib-type="author"><name><surname>Metspalu</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Ridker</surname><given-names>P. M.</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Wareham</surname><given-names>N. J.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Loos</surname><given-names>R. J. F.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A62">62</xref></contrib><contrib contrib-type="author"><name><surname>Tiemeier</surname><given-names>H.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A63">63</xref><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Sonestedt</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="A65">65</xref></contrib><contrib contrib-type="author"><name><surname>Sørensen</surname><given-names>T. I. A.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A15">15</xref><xref ref-type="aff" rid="A66">66</xref></contrib><xref ref-type="author-notes" rid="FN1">†</xref></contrib-group><aff id="A1"><label>1</label>Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark</aff><aff id="A2"><label>2</label>Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands</aff><aff id="A3"><label>3</label>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK</aff><aff id="A4"><label>4</label>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA</aff><aff id="A5"><label>5</label>Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A6"><label>6</label>Estonian Genome Center, University of Tartu, Tartu, Estonia</aff><aff id="A7"><label>7</label>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, USA</aff><aff id="A8"><label>8</label>Icelandic Heart Association, Kopavogur, Iceland</aff><aff id="A9"><label>9</label>University of Icelandic, Reykajvik, Iceland</aff><aff id="A10"><label>10</label>The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark</aff><aff id="A11"><label>11</label>Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany</aff><aff id="A12"><label>12</label>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA</aff><aff id="A13"><label>13</label>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A14"><label>14</label>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A15"><label>15</label>MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK</aff><aff id="A16"><label>16</label>Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany</aff><aff id="A17"><label>17</label>Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA</aff><aff id="A18"><label>18</label>Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland</aff><aff id="A19"><label>19</label>School of Medicine, University of Tampere, Tampere, Finland</aff><aff id="A20"><label>20</label>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A21"><label>21</label>Department of Medicine I, Ludwig-Maximilians-University, Munich, Germany</aff><aff id="A22"><label>22</label>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</aff><aff id="A23"><label>23</label>Institute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A24"><label>24</label>Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK), Partner site Munich Heart Alliance, Munich, Germany</aff><aff id="A25"><label>25</label>Karolinska Institutet, Institute of Environmental Medicine, Unit of Cardiovascular Epidemiology, Stockholm, Sweden</aff><aff id="A26"><label>26</label>Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland</aff><aff id="A27"><label>27</label>MRC Unit for Lifelong Health and Ageing, University College London, London, UK</aff><aff id="A28"><label>28</label>Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany</aff><aff id="A29"><label>29</label>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany</aff><aff id="A30"><label>30</label>QIMR Berghofer Medical Research Institute, Brisbane, Australia</aff><aff id="A31"><label>31</label>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A32"><label>32</label>Institute of Regional Health Services Research and Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark</aff><aff id="A33"><label>33</label>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland</aff><aff id="A34"><label>34</label>Danish Cancer Society Research Centre, Copenhagen, Denmark</aff><aff id="A35"><label>35</label>Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A36"><label>36</label>Department of General Practice and Primary Health Care, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland</aff><aff id="A37"><label>37</label>Folkhälsan Research Centre, Helsinki, Finland</aff><aff id="A38"><label>38</label>Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A39"><label>39</label>Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A40"><label>40</label>Department of Genetic, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A41"><label>41</label>Durrer Center for Cardiogenetic Research, ICIN-Neterlands Heart Institute, Utrecht, The Netherlands</aff><aff id="A42"><label>42</label>Department of Epidemiology and Public Health, University College London, London, UK</aff><aff id="A43"><label>43</label>ISER, University of Essex, Colchester, UK</aff><aff id="A44"><label>44</label>Inserm, U744, Institut Pasteur de Lille, University Lille Nord de France, Lille, France</aff><aff id="A45"><label>45</label>Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A46"><label>46</label>Centre for Vascular Prevention, Danube-University Krems, Krems, Austria</aff><aff id="A47"><label>47</label>Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), Madrid, Spain</aff><aff id="A48"><label>48</label>Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia</aff><aff id="A49"><label>49</label>School of Social and Community Medicine, University of Bristol, Bristol, UK</aff><aff id="A50"><label>50</label>BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK</aff><aff id="A51"><label>51</label>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</aff><aff id="A52"><label>52</label>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</aff><aff id="A53"><label>53</label>Institute of Cardiovascular Science, University College London, London, UK</aff><aff id="A54"><label>54</label>Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA</aff><aff id="A55"><label>55</label>Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany</aff><aff id="A56"><label>56</label>Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria</aff><aff id="A57"><label>57</label>Synlab Academy, Synlab Services GmbH, Mannheim, Germany</aff><aff id="A58"><label>58</label>Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</aff><aff id="A59"><label>59</label>Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark</aff><aff id="A60"><label>60</label>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A61"><label>61</label>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A62"><label>62</label>The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA</aff><aff id="A63"><label>63</label>Department of Child and Adolescent Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands</aff><aff id="A64"><label>64</label>Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands</aff><aff id="A65"><label>65</label>Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden</aff><aff id="A66"><label>66</label>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section on Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark</aff><author-notes><fn id="FN1"><label>†</label><p id="P1">The FTO-Mortality Collaborating Group, contributing cohort data, includes the following:</p><p id="P2">M. Orho-Melander<sup>1</sup>, C. Zillikens<sup>2</sup>, A. Ikram<sup>3,4,5</sup>, A. Hofman<sup>3</sup>, J. Luan<sup>6</sup>, K. T. Khaw<sup>7</sup>, L. M. Rose<sup>8</sup>, K. Läll<sup>9</sup>, R. Mägi<sup>9</sup>, L. Qi<sup>10</sup>, Q. Sun<sup>10</sup>, T. B. Harris<sup>11,15</sup>, L. J. Launer<sup>11</sup>, G. Eiriksdottir<sup>12</sup>, M. E. Kleber<sup>13</sup>, G. Delgado<sup>13</sup>, Y. Liu<sup>14</sup>, M. Garcia<sup>15</sup>, A. Teumer<sup>16</sup>, H. Grabe<sup>17</sup>, G. Homuth<sup>18</sup>, J. W. Jukema<sup>19,20,21</sup>, I. Ford<sup>22</sup>, A. J. M. de Craen<sup>23</sup>, J. Gallacher<sup>24</sup>, J. Yarnell<sup>25</sup>, A. A. Mahabadi<sup>26</sup>, M. M. Nöthen<sup>27</sup>, R. Erbel<sup>26</sup>, H. M. Stringham<sup>28</sup>, M. Boehnke<sup>28</sup>, P. Amouyel<sup>29</sup>, J. Ferrières<sup>30,31,32</sup>, D. Arveiler<sup>33</sup>, M. Kähönen<sup>34,35</sup>, K. Nikus<sup>36</sup>, T. Nieminen<sup>37,38,39</sup>, A. Sanchez<sup>40</sup>, M. Kivimaki<sup>40</sup>, J. V. van Vliet-Ostaptchouk<sup>41,42</sup>, R. Hampel<sup>43</sup>, B. Thorand<sup>43</sup>, U. De Faire<sup>44</sup>, F. Nyberg<sup>45,46</sup>, D. Kuh<sup>47</sup>, N. G. Martin<sup>48</sup>, G. W. Montgomery<sup>48</sup>, A. C. Heath<sup>49</sup>, P. A. F. Madden<sup>49</sup>, C. Osmond<sup>50</sup>, N. Pulizzi<sup>51</sup>, N. Roswall<sup>52</sup>, J. Halkjær<sup>52</sup>, K. Overvad<sup>53,54</sup>, M. Uusitupa<sup>55,56</sup>, L. Kinnunen<sup>57</sup>, J. Lindström<sup>57</sup>, J. Saramies<sup>58</sup>, S. Keinänen-Kiukaanniemi<sup>59</sup>, H. Uusitalo<sup>60</sup>, E. Hussi<sup>58</sup>, D. Baldassarre<sup>61,62</sup>, F. Veglia<sup>62</sup>, S. Humphries<sup>63</sup>, E. Tremoli<sup>61,62</sup> and B. Heitmann<sup>64</sup><sup>1</sup>Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden; <sup>2</sup>Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands; <sup>3</sup>Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands; <sup>4</sup>Department of Neurology, Erasmus Medical Centre, Rotterdam, The Netherlands; <sup>5</sup>Department of Radiology, Erasmus Medical Centre, Rotterdam, The Netherlands; <sup>6</sup>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK; <sup>7</sup>MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; <sup>8</sup>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; <sup>9</sup>Estonian Genome Center, University of Tartu, Tartu, Estonia; <sup>10</sup>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA; <sup>11</sup>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA; <sup>12</sup>Icelandic Heart Association, Kopavogur, Iceland; <sup>13</sup>Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany; <sup>14</sup>Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, North Carolina, USA; <sup>15</sup>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA; <sup>16</sup>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; <sup>17</sup>Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany; <sup>18</sup>Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-MoritzArndt-University Greifswald, Greifswald, Germany; <sup>19</sup>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; <sup>20</sup>Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands; <sup>21</sup>Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands; <sup>22</sup>Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK; <sup>23</sup>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands; <sup>24</sup>Institute of Primary Care and Public Health, Cardiff University School of Medicine, Cardiff, UK; <sup>25</sup>Epidemiology Research Group, Queen's University Belfast, Belfast, UK; <sup>26</sup>West-German Heart Center Essen, Department of Cardiology, University of Duisburg-Essen, Essen, Germany; <sup>27</sup>Institute of Human Genetics, University of Bonn, Bonn, Germany; <sup>28</sup>Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA; <sup>29</sup>Inserm, U744, Institut Pasteur de Lille, University Lille Nord de France, UDSL, Lille, France; <sup>30</sup>Hôpital Rangueil, Toulouse, France; <sup>31</sup>INSERM U1027, Toulouse, France; <sup>32</sup>Université Paul Sabatier Toulouse, Toulouse, France; <sup>33</sup>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France; <sup>34</sup>Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland; <sup>35</sup>School of Medicine, University of Tampere, Tampere, Finland; <sup>36</sup>Heart Hospital Co., Department of Cardio-Thoracic Surgery, Tampere University Hospital, Tampere, Finland; <sup>37</sup>Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland; <sup>38</sup>Department of Internal Medicine, Päijät-Häme Central Hospital, Lahti, Finland; <sup>39</sup>Department of Clinical Pharmacology, University of Tampere, Tampere, Finland; <sup>40</sup>Department of Epidemiology and Public Health, University College London, London, UK; <sup>41</sup>Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; <sup>42</sup>Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; <sup>43</sup>Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany; <sup>44</sup>Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; <sup>45</sup>Occupational and Environmental Medicine, Department of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; <sup>46</sup>AstraZeneca R&D, Mölndal, Sweden; <sup>47</sup>MRC Unit for Lifelong Health and Ageing, University College London, London, UK; <sup>48</sup>QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; <sup>49</sup>Department of Psychiatry, Washington University, St Louis, Missouri, USA; <sup>50</sup>MRC Epidemiology Resource Centre, Southampton General Hospital, University of Southampton, Southampton, UK; <sup>51</sup>Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy; <sup>52</sup>Danish Cancer Society Research Centre, Copenhagen, Denmark; <sup>53</sup>Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark; <sup>54</sup>Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark; <sup>55</sup>Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; <sup>56</sup>Research Unit, Kuopio University Hospital, Kuopio, Finland; <sup>57</sup>Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; <sup>58</sup>South Karelia Central Hospital, Lappeenranta, Finland; <sup>59</sup>Faculty of Medicine, Institute of Health Sciences, Oulu University, Oulu, Finland; <sup>60</sup>Department of Ophthalmology, Tampere University, Tampere, Finland; <sup>61</sup>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy; <sup>62</sup>Centro Cardiologico Monzino, IRCCS, Milan, Italy; <sup>63</sup>Centre for Cardiovascular Genetics, University College London, London, UK; <sup>64</sup>Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark</p></fn><corresp id="CR1">Address for correspondence: Dr E Zimmermann, Institute of Preventive Medicine, Frederiksberg Hospital, Nordre Fasanvej 57, Hovedvejen, Indgang 5, stuen, 2000 Frederiksberg, Denmark. <email>esther.zimmermann@regionh.dk</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>28</day><month>8</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>05</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>4</month><year>2016</year></pub-date><volume>16</volume><issue>4</issue><fpage>327</fpage><lpage>340</lpage><pmc-comment>elocation-id from pubmed: 10.1111/obr.12263</pmc-comment>
<abstract><title>Summary</title><p id="P3">Previously, a single nucleotide polymorphism (SNP), rs9939609, in the <italic>FTO</italic> gene showed a much stronger association with all-cause mortality than expected from its association with body mass index (BMI), body fat mass index (FMI) and waist circumference (WC). This finding implies that the SNP has strong pleiotropic effects on adiposity and adiposity-independent pathological pathways that leads to increased mortality. To investigate this further, we conducted a meta-analysis of similar data from 34 longitudinal studies including 169,551 adult Caucasians among whom 27,100 died during follow-up. Linear regression showed that the minor allele of the <italic>FTO</italic> SNP was associated with greater BMI (<italic>n</italic> = 169,551; 0.32 kg m<sup>−2</sup>; 95% CI 0.28–0.32, <italic>P</italic> < 1 × 10<sup>−32</sup>), WC (<italic>n</italic> = 152,631; 0.76 cm; 0.68–0.84, <italic>P</italic> < 1 × 10<sup>−32</sup>) and FMI (<italic>n</italic> = 48,192; 0.17 kg m<sup>−2</sup>; 0.13–0.22, <italic>P</italic> = 1.0 × 10<sup>−13</sup>). Cox proportional hazard regression analyses for mortality showed that the hazards ratio (HR) for the minor allele of the <italic>FTO</italic> SNPs was 1.02 (1.00–1.04, <italic>P</italic> = 0.097), but the apparent excess risk was eliminated after adjustment for BMI and WC (HR: 1.00; 0.98–1.03, <italic>P</italic> = 0.662) and for FMI (HR: 1.00; 0.96–1.04, <italic>P</italic> = 0.932). In conclusion, this study does not support that the <italic>FTO</italic> SNP is associated with all-cause mortality independently of the adiposity phenotypes.</p></abstract><kwd-group><kwd><italic>FTO</italic></kwd><kwd>meta-analysis</kwd><kwd>mortality</kwd><kwd>obesity</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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