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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Determinants of weight evolution among HIV-positive patients initiating antiretroviral treatment in low resource settings</title><author><name sortKey="Huis In Veld, D" sort="Huis In Veld, D" uniqKey="Huis In Veld D" first="D." last="Huis In Veld">D. Huis In Veld</name><affiliation><nlm:aff id="A1">Department of Epidemiology and Social Medicine, University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Clinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Fonds Wetenschappelijk Onderzoek-Vlaanderen. Aspirant Mandate holder. FWO, Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Balestre, E" sort="Balestre, E" uniqKey="Balestre E" first="E." last="Balestre">E. Balestre</name><affiliation><nlm:aff id="A4">Université Bordeaux, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, F-33000 Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="Buyze, J" sort="Buyze, J" uniqKey="Buyze J" first="J" last="Buyze">J. Buyze</name><affiliation><nlm:aff id="A2">Clinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium</nlm:aff></affiliation></author><author><name sortKey="Menten, J" sort="Menten, J" uniqKey="Menten J" first="J." last="Menten">J. Menten</name><affiliation><nlm:aff id="A2">Clinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium</nlm:aff></affiliation></author><author><name sortKey="Jaquet, A" sort="Jaquet, A" uniqKey="Jaquet A" first="A." last="Jaquet">A. Jaquet</name><affiliation><nlm:aff id="A4">Université Bordeaux, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, F-33000 Bordeaux, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">ISPED, Centre INSERM U 897-Epidemiologie-Biostatistique, University of Bordeaux, Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="Cooper, D A" sort="Cooper, D A" uniqKey="Cooper D" first="D. A." last="Cooper">D. A. Cooper</name><affiliation><nlm:aff id="A6">Kirby Institute University of New South Wales and Centre for Applied Medical Research, St Vincent’s Hospital, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Dabis, F" sort="Dabis, F" uniqKey="Dabis F" first="F." last="Dabis">F. Dabis</name><affiliation><nlm:aff id="A4">Université Bordeaux, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, F-33000 Bordeaux, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">ISPED, Centre INSERM U 897-Epidemiologie-Biostatistique, University of Bordeaux, Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="Yiannoutsos, C T" sort="Yiannoutsos, C T" uniqKey="Yiannoutsos C" first="C. T." last="Yiannoutsos">C. T. Yiannoutsos</name><affiliation><nlm:aff id="A7">Department of Biostatistics, Indiana University School of Public Health, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Diero, L" sort="Diero, L" uniqKey="Diero L" first="L." last="Diero">L. Diero</name><affiliation><nlm:aff id="A8">Department of Medicine, Moi University/Ampath Eldoret Kenya</nlm:aff></affiliation></author><author><name sortKey="Mutevedzi, P" sort="Mutevedzi, P" uniqKey="Mutevedzi P" first="P." last="Mutevedzi">P. Mutevedzi</name><affiliation><nlm:aff id="A9">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Infection and Population Health, University College London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Fox, M P" sort="Fox, M P" uniqKey="Fox M" first="M. P." last="Fox">M. P. Fox</name><affiliation><nlm:aff id="A11">Centre for Global Health & Development, Boston University, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand</nlm:aff></affiliation></author><author><name sortKey="Messou, E" sort="Messou, E" uniqKey="Messou E" first="E." last="Messou">E. Messou</name><affiliation><nlm:aff id="A13">Centre de prise en charge de recherche et de formation (CePReF), Hôpital Yopougon Attié, Abidjan, Côte d'Ivoire</nlm:aff></affiliation></author><author><name sortKey="Hoffmann, C J" sort="Hoffmann, C J" uniqKey="Hoffmann C" first="C. J." last="Hoffmann">C. J. Hoffmann</name><affiliation><nlm:aff id="A14">The Aurum Institute, Johannesburg, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="A15">John Hopkins University, Baltimore, USA</nlm:aff></affiliation></author><author><name sortKey="Prozesky, H W" sort="Prozesky, H W" uniqKey="Prozesky H" first="H. W." last="Prozesky">H. W. Prozesky</name><affiliation><nlm:aff id="A16">Division of Infectious Diseases, Department of Medicine, University of Stellenbosch and Tygerberg Academic Hospital, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Egger, M" sort="Egger, M" uniqKey="Egger M" first="M." last="Egger">M. Egger</name><affiliation><nlm:aff id="A17">Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Hemingway Foday, J J" sort="Hemingway Foday, J J" uniqKey="Hemingway Foday J" first="J. J." last="Hemingway-Foday">J. J. Hemingway-Foday</name><affiliation><nlm:aff id="A19">RTI International, Research Triangle Park, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Colebunders, R" sort="Colebunders, R" uniqKey="Colebunders R" first="R." last="Colebunders">R. Colebunders</name><affiliation><nlm:aff id="A1">Department of Epidemiology and Social Medicine, University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Clinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26375465</idno><idno type="pmc">4576726</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576726</idno><idno type="RBID">PMC:4576726</idno><idno type="doi">10.1097/QAI.0000000000000691</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001D67</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D67</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Determinants of weight evolution among HIV-positive patients initiating antiretroviral treatment in low resource settings</title><author><name sortKey="Huis In Veld, D" sort="Huis In Veld, D" uniqKey="Huis In Veld D" first="D." last="Huis In Veld">D. Huis In Veld</name><affiliation><nlm:aff id="A1">Department of Epidemiology and Social Medicine, University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Clinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Fonds Wetenschappelijk Onderzoek-Vlaanderen. Aspirant Mandate holder. FWO, Brussels, Belgium</nlm:aff></affiliation></author><author><name sortKey="Balestre, E" sort="Balestre, E" uniqKey="Balestre E" first="E." last="Balestre">E. Balestre</name><affiliation><nlm:aff id="A4">Université Bordeaux, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, F-33000 Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="Buyze, J" sort="Buyze, J" uniqKey="Buyze J" first="J" last="Buyze">J. Buyze</name><affiliation><nlm:aff id="A2">Clinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium</nlm:aff></affiliation></author><author><name sortKey="Menten, J" sort="Menten, J" uniqKey="Menten J" first="J." last="Menten">J. Menten</name><affiliation><nlm:aff id="A2">Clinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium</nlm:aff></affiliation></author><author><name sortKey="Jaquet, A" sort="Jaquet, A" uniqKey="Jaquet A" first="A." last="Jaquet">A. Jaquet</name><affiliation><nlm:aff id="A4">Université Bordeaux, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, F-33000 Bordeaux, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">ISPED, Centre INSERM U 897-Epidemiologie-Biostatistique, University of Bordeaux, Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="Cooper, D A" sort="Cooper, D A" uniqKey="Cooper D" first="D. A." last="Cooper">D. A. Cooper</name><affiliation><nlm:aff id="A6">Kirby Institute University of New South Wales and Centre for Applied Medical Research, St Vincent’s Hospital, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Dabis, F" sort="Dabis, F" uniqKey="Dabis F" first="F." last="Dabis">F. Dabis</name><affiliation><nlm:aff id="A4">Université Bordeaux, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, F-33000 Bordeaux, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5">ISPED, Centre INSERM U 897-Epidemiologie-Biostatistique, University of Bordeaux, Bordeaux, France</nlm:aff></affiliation></author><author><name sortKey="Yiannoutsos, C T" sort="Yiannoutsos, C T" uniqKey="Yiannoutsos C" first="C. T." last="Yiannoutsos">C. T. Yiannoutsos</name><affiliation><nlm:aff id="A7">Department of Biostatistics, Indiana University School of Public Health, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Diero, L" sort="Diero, L" uniqKey="Diero L" first="L." last="Diero">L. Diero</name><affiliation><nlm:aff id="A8">Department of Medicine, Moi University/Ampath Eldoret Kenya</nlm:aff></affiliation></author><author><name sortKey="Mutevedzi, P" sort="Mutevedzi, P" uniqKey="Mutevedzi P" first="P." last="Mutevedzi">P. Mutevedzi</name><affiliation><nlm:aff id="A9">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Infection and Population Health, University College London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Fox, M P" sort="Fox, M P" uniqKey="Fox M" first="M. P." last="Fox">M. P. Fox</name><affiliation><nlm:aff id="A11">Centre for Global Health & Development, Boston University, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand</nlm:aff></affiliation></author><author><name sortKey="Messou, E" sort="Messou, E" uniqKey="Messou E" first="E." last="Messou">E. Messou</name><affiliation><nlm:aff id="A13">Centre de prise en charge de recherche et de formation (CePReF), Hôpital Yopougon Attié, Abidjan, Côte d'Ivoire</nlm:aff></affiliation></author><author><name sortKey="Hoffmann, C J" sort="Hoffmann, C J" uniqKey="Hoffmann C" first="C. J." last="Hoffmann">C. J. Hoffmann</name><affiliation><nlm:aff id="A14">The Aurum Institute, Johannesburg, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="A15">John Hopkins University, Baltimore, USA</nlm:aff></affiliation></author><author><name sortKey="Prozesky, H W" sort="Prozesky, H W" uniqKey="Prozesky H" first="H. W." last="Prozesky">H. W. Prozesky</name><affiliation><nlm:aff id="A16">Division of Infectious Diseases, Department of Medicine, University of Stellenbosch and Tygerberg Academic Hospital, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Egger, M" sort="Egger, M" uniqKey="Egger M" first="M." last="Egger">M. Egger</name><affiliation><nlm:aff id="A17">Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Hemingway Foday, J J" sort="Hemingway Foday, J J" uniqKey="Hemingway Foday J" first="J. J." last="Hemingway-Foday">J. J. Hemingway-Foday</name><affiliation><nlm:aff id="A19">RTI International, Research Triangle Park, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Colebunders, R" sort="Colebunders, R" uniqKey="Colebunders R" first="R." last="Colebunders">R. Colebunders</name><affiliation><nlm:aff id="A1">Department of Epidemiology and Social Medicine, University of Antwerp, Antwerp, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Clinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of acquired immune deficiency syndromes (1999)</title><idno type="ISSN">1525-4135</idno><idno type="eISSN">1944-7884</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">In resource limited settings clinical parameters, including body weight changes, are used to monitor clinical response. Therefore we studied body weight changes in patients on antiretroviral treatment (ART) in different regions of the world.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Data were extracted from the “International Epidemiologic Databases to Evaluate AIDS”, a network of ART programmes that prospectively collects routine clinical data. Adults on ART from the Southern-, East-, West- and Central African and the Asia-Pacific regions were selected from the database if baseline data on body weight, gender, ART regimen and CD4 count were available. Body weight change over the first two years and the probability of body weight loss in the second year were modelled using linear mixed models and logistic regression respectively.</p></sec><sec id="S3"><title>Results</title><p id="P3">Data from 205,571 patients were analysed. Mean adjusted body weight change in the first 12 months was higher in patients started on tenofovir and/or efavirenz; in patients from Central, West and East Africa, in men, and in patients with a poorer clinical status. In the second year of ART it was greater in patients initiated on tenofovir and/or nevirapine, and for patients not on stavudine, in women, in Southern Africa and in patients with a better clinical status at initiation. Stavudine in the initial regimen was associated with a lower mean adjusted body weight change and with weight loss in the second treatment year.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Different ART regimens have different effects on body weight change. Body weight loss after one year of treatment in patients on stavudine might be associated with lipoatrophy.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100892005</journal-id><journal-id journal-id-type="pubmed-jr-id">21821</journal-id><journal-id journal-id-type="nlm-ta">J Acquir Immune Defic Syndr</journal-id><journal-id journal-id-type="iso-abbrev">J. Acquir. Immune Defic. Syndr.</journal-id><journal-title-group><journal-title>Journal of acquired immune deficiency syndromes (1999)</journal-title></journal-title-group><issn pub-type="ppub">1525-4135</issn><issn pub-type="epub">1944-7884</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26375465</article-id><article-id pub-id-type="pmc">4576726</article-id><article-id pub-id-type="doi">10.1097/QAI.0000000000000691</article-id><article-id pub-id-type="manuscript">NIHMS688552</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Determinants of weight evolution among HIV-positive patients initiating antiretroviral treatment in low resource settings</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Huis in ‘t Veld</surname><given-names>D.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Balestre</surname><given-names>E.</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Buyze</surname><given-names>J</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Menten</surname><given-names>J.</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Jaquet</surname><given-names>A.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Cooper</surname><given-names>D.A.</given-names></name><degrees>MD, DSc</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Dabis</surname><given-names>F.</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Yiannoutsos</surname><given-names>C. T.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Diero</surname><given-names>L.</given-names></name><degrees>MBChB, MMed</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Mutevedzi</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Fox</surname><given-names>M.P.</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Messou</surname><given-names>E.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Hoffmann</surname><given-names>C.J.</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="A14">14</xref><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Prozesky</surname><given-names>H.W.</given-names></name><degrees>MBChB, MMed</degrees><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Egger</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="A17">17</xref><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Hemingway-Foday</surname><given-names>J.J.</given-names></name><degrees>MPH, MSW</degrees><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Colebunders</surname><given-names>R.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><collab>for the International Epidemiologic Databases to Evaluate AIDS (IeDEA)</collab></contrib></contrib-group><aff id="A1"><label>1</label>Department of Epidemiology and Social Medicine, University of Antwerp, Antwerp, Belgium</aff><aff id="A2"><label>2</label>Clinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium</aff><aff id="A3"><label>3</label>Fonds Wetenschappelijk Onderzoek-Vlaanderen. Aspirant Mandate holder. FWO, Brussels, Belgium</aff><aff id="A4"><label>4</label>Université Bordeaux, ISPED, Centre INSERM U897-Epidémiologie-Biostatistique, F-33000 Bordeaux, France</aff><aff id="A5"><label>5</label>ISPED, Centre INSERM U 897-Epidemiologie-Biostatistique, University of Bordeaux, Bordeaux, France</aff><aff id="A6"><label>6</label>Kirby Institute University of New South Wales and Centre for Applied Medical Research, St Vincent’s Hospital, Sydney, Australia</aff><aff id="A7"><label>7</label>Department of Biostatistics, Indiana University School of Public Health, Indianapolis, IN, USA</aff><aff id="A8"><label>8</label>Department of Medicine, Moi University/Ampath Eldoret Kenya</aff><aff id="A9"><label>9</label>Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa</aff><aff id="A10"><label>10</label>Department of Infection and Population Health, University College London, London, United Kingdom</aff><aff id="A11"><label>11</label>Centre for Global Health & Development, Boston University, Boston, MA, USA</aff><aff id="A12"><label>12</label>Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand</aff><aff id="A13"><label>13</label>Centre de prise en charge de recherche et de formation (CePReF), Hôpital Yopougon Attié, Abidjan, Côte d'Ivoire</aff><aff id="A14"><label>14</label>The Aurum Institute, Johannesburg, South Africa</aff><aff id="A15"><label>15</label>John Hopkins University, Baltimore, USA</aff><aff id="A16"><label>16</label>Division of Infectious Diseases, Department of Medicine, University of Stellenbosch and Tygerberg Academic Hospital, Cape Town, South Africa</aff><aff id="A17"><label>17</label>Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland</aff><aff id="A18"><label>18</label>Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, South Africa</aff><aff id="A19"><label>19</label>RTI International, Research Triangle Park, NC, USA</aff><author-notes><corresp id="cor1">Correspondence: Name: D. Huis in ‘t Veld, Address: Bergstraat 77, 6811 LD, Arnhem, The Netherlands, Telephone number: +31633236892, <email>dianahitv@hotmail.com</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>13</day><month>5</month><year>2015</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>10</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2016</year></pub-date><volume>70</volume><issue>2</issue><fpage>146</fpage><lpage>154</lpage><pmc-comment>elocation-id from pubmed: 10.1097/QAI.0000000000000691</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">In resource limited settings clinical parameters, including body weight changes, are used to monitor clinical response. Therefore we studied body weight changes in patients on antiretroviral treatment (ART) in different regions of the world.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Data were extracted from the “International Epidemiologic Databases to Evaluate AIDS”, a network of ART programmes that prospectively collects routine clinical data. Adults on ART from the Southern-, East-, West- and Central African and the Asia-Pacific regions were selected from the database if baseline data on body weight, gender, ART regimen and CD4 count were available. Body weight change over the first two years and the probability of body weight loss in the second year were modelled using linear mixed models and logistic regression respectively.</p></sec><sec id="S3"><title>Results</title><p id="P3">Data from 205,571 patients were analysed. Mean adjusted body weight change in the first 12 months was higher in patients started on tenofovir and/or efavirenz; in patients from Central, West and East Africa, in men, and in patients with a poorer clinical status. In the second year of ART it was greater in patients initiated on tenofovir and/or nevirapine, and for patients not on stavudine, in women, in Southern Africa and in patients with a better clinical status at initiation. Stavudine in the initial regimen was associated with a lower mean adjusted body weight change and with weight loss in the second treatment year.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Different ART regimens have different effects on body weight change. Body weight loss after one year of treatment in patients on stavudine might be associated with lipoatrophy.</p></sec></abstract><kwd-group><kwd>HIV</kwd><kwd>bodyweight</kwd><kwd>determinants</kwd><kwd>ART</kwd><kwd>low-resource</kwd><kwd>settings</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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