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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome</title><author><name sortKey="Harris, Valerie M" sort="Harris, Valerie M" uniqKey="Harris V" first="Valerie M." last="Harris">Valerie M. Harris</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Sharma, Rohan" sort="Sharma, Rohan" uniqKey="Sharma R" first="Rohan" last="Sharma">Rohan Sharma</name><affiliation><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Cavett, Joshua" sort="Cavett, Joshua" uniqKey="Cavett J" first="Joshua" last="Cavett">Joshua Cavett</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Kurien, Biji T" sort="Kurien, Biji T" uniqKey="Kurien B" first="Biji T." last="Kurien">Biji T. Kurien</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Liu, Ke" sort="Liu, Ke" uniqKey="Liu K" first="Ke" last="Liu">Ke Liu</name><affiliation><nlm:aff id="A5">Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff></affiliation></author><author><name sortKey="Koelsch, Kristi A" sort="Koelsch, Kristi A" uniqKey="Koelsch K" first="Kristi A." last="Koelsch">Kristi A. Koelsch</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Rasmussen, Astrid" sort="Rasmussen, Astrid" uniqKey="Rasmussen A" first="Astrid" last="Rasmussen">Astrid Rasmussen</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Radfar, Lida" sort="Radfar, Lida" uniqKey="Radfar L" first="Lida" last="Radfar">Lida Radfar</name><affiliation><nlm:aff id="A7">Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA</nlm:aff></affiliation></author><author><name sortKey="Lewis, David" sort="Lewis, David" uniqKey="Lewis D" first="David" last="Lewis">David Lewis</name><affiliation><nlm:aff id="A7">Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA</nlm:aff></affiliation></author><author><name sortKey="Stone, Donald U" sort="Stone, Donald U" uniqKey="Stone D" first="Donald U." last="Stone">Donald U. Stone</name><affiliation><nlm:aff id="A8">Dean McGee Eye Institute and Department of Ophthalmology, University of Oklahoma College of Medicine, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Kaufman, C Erick" sort="Kaufman, C Erick" uniqKey="Kaufman C" first="C. Erick" last="Kaufman">C. Erick Kaufman</name><affiliation><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Shibo" sort="Li, Shibo" uniqKey="Li S" first="Shibo" last="Li">Shibo Li</name><affiliation><nlm:aff id="A9">Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA</nlm:aff></affiliation></author><author><name sortKey="Segal, Barbara" sort="Segal, Barbara" uniqKey="Segal B" first="Barbara" last="Segal">Barbara Segal</name><affiliation><nlm:aff id="A10">Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Wallace, Daniel J" sort="Wallace, Daniel J" uniqKey="Wallace D" first="Daniel J" last="Wallace">Daniel J. Wallace</name><affiliation><nlm:aff id="A11">Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H." last="Weisman">Michael H. Weisman</name><affiliation><nlm:aff id="A11">Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Venuturupalli, Swamy" sort="Venuturupalli, Swamy" uniqKey="Venuturupalli S" first="Swamy" last="Venuturupalli">Swamy Venuturupalli</name><affiliation><nlm:aff id="A11">Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Kelly, Jennifer A" sort="Kelly, Jennifer A" uniqKey="Kelly J" first="Jennifer A." last="Kelly">Jennifer A. Kelly</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Alarcon Riquelme, Marta E" sort="Alarcon Riquelme, Marta E" uniqKey="Alarcon Riquelme M" first="Marta E." last="Alarcon-Riquelme">Marta E. Alarcon-Riquelme</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Center Pfizer, University of Granada, Andalusian Government for Genomics and Oncological Research, PTS Granada, 18016, Spain</nlm:aff></affiliation></author><author><name sortKey="Pons Estel, Bernardo" sort="Pons Estel, Bernardo" uniqKey="Pons Estel B" first="Bernardo" last="Pons-Estel">Bernardo Pons-Estel</name><affiliation><nlm:aff id="A13">Sanatorio Parque, Rosario, Argentina</nlm:aff></affiliation></author><author><name sortKey="Jonsson, Roland" sort="Jonsson, Roland" uniqKey="Jonsson R" first="Roland" last="Jonsson">Roland Jonsson</name><affiliation><nlm:aff id="A15">Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Rheumatology, Haukeland University Hospital, Bergen 5021, Norway</nlm:aff></affiliation></author><author><name sortKey="Lu, Xianglan" sort="Lu, Xianglan" uniqKey="Lu X" first="Xianglan" last="Lu">Xianglan Lu</name><affiliation><nlm:aff id="A9">Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA</nlm:aff></affiliation></author><author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name><affiliation><nlm:aff id="A17">Strasbourg University, Strasbourg, France</nlm:aff></affiliation></author><author><name sortKey="Anaya, Juan Manuel" sort="Anaya, Juan Manuel" uniqKey="Anaya J" first="Juan-Manuel" last="Anaya">Juan-Manuel Anaya</name><affiliation><nlm:aff id="A18">Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia</nlm:aff></affiliation></author><author><name sortKey="Cunninghame Graham, Deborah S" sort="Cunninghame Graham, Deborah S" uniqKey="Cunninghame Graham D" first="Deborah S." last="Cunninghame-Graham">Deborah S. Cunninghame-Graham</name><affiliation><nlm:aff id="A19">Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Huang, Andrew J W" sort="Huang, Andrew J W" uniqKey="Huang A" first="Andrew J. W." last="Huang">Andrew J. W. Huang</name><affiliation><nlm:aff id="A14">Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Brennan, Michael T" sort="Brennan, Michael T" uniqKey="Brennan M" first="Michael T." last="Brennan">Michael T. Brennan</name><affiliation><nlm:aff id="A20">Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA</nlm:aff></affiliation></author><author><name sortKey="Hughes, Pamela" sort="Hughes, Pamela" uniqKey="Hughes P" first="Pamela" last="Hughes">Pamela Hughes</name><affiliation><nlm:aff id="A14">Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Alevizos, Ilias" sort="Alevizos, Ilias" uniqKey="Alevizos I" first="Ilias" last="Alevizos">Ilias Alevizos</name><affiliation><nlm:aff id="A21">Molecular Physiology & Therapeutic Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Miceli Richard, Corinne" sort="Miceli Richard, Corinne" uniqKey="Miceli Richard C" first="Corinne" last="Miceli-Richard">Corinne Miceli-Richard</name><affiliation><nlm:aff id="A22">Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France</nlm:aff></affiliation></author><author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name><affiliation><nlm:aff id="A23">Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario</nlm:aff></affiliation></author><author><name sortKey="Bykerk, Vivian P" sort="Bykerk, Vivian P" uniqKey="Bykerk V" first="Vivian P." last="Bykerk">Vivian P. Bykerk</name><affiliation><nlm:aff id="A24">Hospital for Special Surgery, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Hirschfield, Gideon" sort="Hirschfield, Gideon" uniqKey="Hirschfield G" first="Gideon" last="Hirschfield">Gideon Hirschfield</name><affiliation><nlm:aff id="A25">NIHR Biomedical Research Unit, University of Birmingham, Birmingham, UK</nlm:aff></affiliation></author><author><name sortKey="Xie, Gang" sort="Xie, Gang" uniqKey="Xie G" first="Gang" last="Xie">Gang Xie</name><affiliation><nlm:aff id="A26">Samuel Lunenfeld and Toronto General Research Institutes, Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Toronto Ontario</nlm:aff></affiliation></author><author><name sortKey="Ng, Wan Fai" sort="Ng, Wan Fai" uniqKey="Ng W" first="Wan-Fai" last="Ng">Wan-Fai Ng</name><affiliation><nlm:aff id="A27">Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Nordmark, Gunnel" sort="Nordmark, Gunnel" uniqKey="Nordmark G" first="Gunnel" last="Nordmark">Gunnel Nordmark</name><affiliation><nlm:aff id="A28">Section of Rheumatology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Bucher, Sara Magnusson" sort="Bucher, Sara Magnusson" uniqKey="Bucher S" first="Sara Magnusson" last="Bucher">Sara Magnusson Bucher</name><affiliation><nlm:aff id="A29">Department of Rheumatology, Örebro University Hospital, Örebro, Sweden</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name><affiliation><nlm:aff id="A30">Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</nlm:aff></affiliation></author><author><name sortKey="Omdal, Roald" sort="Omdal, Roald" uniqKey="Omdal R" first="Roald" last="Omdal">Roald Omdal</name><affiliation><nlm:aff id="A31">Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway</nlm:aff></affiliation></author><author><name sortKey="Rhodus, Nelson L" sort="Rhodus, Nelson L" uniqKey="Rhodus N" first="Nelson L." last="Rhodus">Nelson L. Rhodus</name><affiliation><nlm:aff id="A32">Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, USA</nlm:aff></affiliation></author><author><name sortKey="Rischmueller, Maureen" sort="Rischmueller, Maureen" uniqKey="Rischmueller M" first="Maureen" last="Rischmueller">Maureen Rischmueller</name><affiliation><nlm:aff id="A33">Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Discipline of Medicine, University of Adelaide, Adelaide, SA 5000, Australia</nlm:aff></affiliation></author><author><name sortKey="Rohrer, Michael" sort="Rohrer, Michael" uniqKey="Rohrer M" first="Michael" last="Rohrer">Michael Rohrer</name><affiliation><nlm:aff id="A14">Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Wahren Herlenius, Marie" sort="Wahren Herlenius, Marie" uniqKey="Wahren Herlenius M" first="Marie" last="Wahren-Herlenius">Marie Wahren-Herlenius</name><affiliation><nlm:aff id="A35">Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Witte, Torsten" sort="Witte, Torsten" uniqKey="Witte T" first="Torsten" last="Witte">Torsten Witte</name><affiliation><nlm:aff id="A36">Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation><nlm:aff id="A22">Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France</nlm:aff></affiliation></author><author><name sortKey="Lessard, Christopher J" sort="Lessard, Christopher J" uniqKey="Lessard C" first="Christopher J." last="Lessard">Christopher J. Lessard</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Harley, John B" sort="Harley, John B" uniqKey="Harley J" first="John B" last="Harley">John B. Harley</name><affiliation><nlm:aff id="A5">Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Medical Service, Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA</nlm:aff></affiliation></author><author><name sortKey="Sivils, Kathy L" sort="Sivils, Kathy L" uniqKey="Sivils K" first="Kathy L" last="Sivils">Kathy L. Sivils</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Scofield, R Hal" sort="Scofield, R Hal" uniqKey="Scofield R" first="R. Hal" last="Scofield">R. Hal Scofield</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27109640</idno><idno type="pmc">4940221</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940221</idno><idno type="RBID">PMC:4940221</idno><idno type="doi">10.1016/j.clim.2016.04.002</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001D61</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D61</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome</title><author><name sortKey="Harris, Valerie M" sort="Harris, Valerie M" uniqKey="Harris V" first="Valerie M." last="Harris">Valerie M. Harris</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Sharma, Rohan" sort="Sharma, Rohan" uniqKey="Sharma R" first="Rohan" last="Sharma">Rohan Sharma</name><affiliation><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Cavett, Joshua" sort="Cavett, Joshua" uniqKey="Cavett J" first="Joshua" last="Cavett">Joshua Cavett</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Kurien, Biji T" sort="Kurien, Biji T" uniqKey="Kurien B" first="Biji T." last="Kurien">Biji T. Kurien</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Liu, Ke" sort="Liu, Ke" uniqKey="Liu K" first="Ke" last="Liu">Ke Liu</name><affiliation><nlm:aff id="A5">Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff></affiliation></author><author><name sortKey="Koelsch, Kristi A" sort="Koelsch, Kristi A" uniqKey="Koelsch K" first="Kristi A." last="Koelsch">Kristi A. Koelsch</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Rasmussen, Astrid" sort="Rasmussen, Astrid" uniqKey="Rasmussen A" first="Astrid" last="Rasmussen">Astrid Rasmussen</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Radfar, Lida" sort="Radfar, Lida" uniqKey="Radfar L" first="Lida" last="Radfar">Lida Radfar</name><affiliation><nlm:aff id="A7">Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA</nlm:aff></affiliation></author><author><name sortKey="Lewis, David" sort="Lewis, David" uniqKey="Lewis D" first="David" last="Lewis">David Lewis</name><affiliation><nlm:aff id="A7">Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA</nlm:aff></affiliation></author><author><name sortKey="Stone, Donald U" sort="Stone, Donald U" uniqKey="Stone D" first="Donald U." last="Stone">Donald U. Stone</name><affiliation><nlm:aff id="A8">Dean McGee Eye Institute and Department of Ophthalmology, University of Oklahoma College of Medicine, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Kaufman, C Erick" sort="Kaufman, C Erick" uniqKey="Kaufman C" first="C. Erick" last="Kaufman">C. Erick Kaufman</name><affiliation><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Shibo" sort="Li, Shibo" uniqKey="Li S" first="Shibo" last="Li">Shibo Li</name><affiliation><nlm:aff id="A9">Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA</nlm:aff></affiliation></author><author><name sortKey="Segal, Barbara" sort="Segal, Barbara" uniqKey="Segal B" first="Barbara" last="Segal">Barbara Segal</name><affiliation><nlm:aff id="A10">Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Wallace, Daniel J" sort="Wallace, Daniel J" uniqKey="Wallace D" first="Daniel J" last="Wallace">Daniel J. Wallace</name><affiliation><nlm:aff id="A11">Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H." last="Weisman">Michael H. Weisman</name><affiliation><nlm:aff id="A11">Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Venuturupalli, Swamy" sort="Venuturupalli, Swamy" uniqKey="Venuturupalli S" first="Swamy" last="Venuturupalli">Swamy Venuturupalli</name><affiliation><nlm:aff id="A11">Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff></affiliation></author><author><name sortKey="Kelly, Jennifer A" sort="Kelly, Jennifer A" uniqKey="Kelly J" first="Jennifer A." last="Kelly">Jennifer A. Kelly</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Alarcon Riquelme, Marta E" sort="Alarcon Riquelme, Marta E" uniqKey="Alarcon Riquelme M" first="Marta E." last="Alarcon-Riquelme">Marta E. Alarcon-Riquelme</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Center Pfizer, University of Granada, Andalusian Government for Genomics and Oncological Research, PTS Granada, 18016, Spain</nlm:aff></affiliation></author><author><name sortKey="Pons Estel, Bernardo" sort="Pons Estel, Bernardo" uniqKey="Pons Estel B" first="Bernardo" last="Pons-Estel">Bernardo Pons-Estel</name><affiliation><nlm:aff id="A13">Sanatorio Parque, Rosario, Argentina</nlm:aff></affiliation></author><author><name sortKey="Jonsson, Roland" sort="Jonsson, Roland" uniqKey="Jonsson R" first="Roland" last="Jonsson">Roland Jonsson</name><affiliation><nlm:aff id="A15">Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Rheumatology, Haukeland University Hospital, Bergen 5021, Norway</nlm:aff></affiliation></author><author><name sortKey="Lu, Xianglan" sort="Lu, Xianglan" uniqKey="Lu X" first="Xianglan" last="Lu">Xianglan Lu</name><affiliation><nlm:aff id="A9">Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA</nlm:aff></affiliation></author><author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name><affiliation><nlm:aff id="A17">Strasbourg University, Strasbourg, France</nlm:aff></affiliation></author><author><name sortKey="Anaya, Juan Manuel" sort="Anaya, Juan Manuel" uniqKey="Anaya J" first="Juan-Manuel" last="Anaya">Juan-Manuel Anaya</name><affiliation><nlm:aff id="A18">Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia</nlm:aff></affiliation></author><author><name sortKey="Cunninghame Graham, Deborah S" sort="Cunninghame Graham, Deborah S" uniqKey="Cunninghame Graham D" first="Deborah S." last="Cunninghame-Graham">Deborah S. Cunninghame-Graham</name><affiliation><nlm:aff id="A19">Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Huang, Andrew J W" sort="Huang, Andrew J W" uniqKey="Huang A" first="Andrew J. W." last="Huang">Andrew J. W. Huang</name><affiliation><nlm:aff id="A14">Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Brennan, Michael T" sort="Brennan, Michael T" uniqKey="Brennan M" first="Michael T." last="Brennan">Michael T. Brennan</name><affiliation><nlm:aff id="A20">Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA</nlm:aff></affiliation></author><author><name sortKey="Hughes, Pamela" sort="Hughes, Pamela" uniqKey="Hughes P" first="Pamela" last="Hughes">Pamela Hughes</name><affiliation><nlm:aff id="A14">Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Alevizos, Ilias" sort="Alevizos, Ilias" uniqKey="Alevizos I" first="Ilias" last="Alevizos">Ilias Alevizos</name><affiliation><nlm:aff id="A21">Molecular Physiology & Therapeutic Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Miceli Richard, Corinne" sort="Miceli Richard, Corinne" uniqKey="Miceli Richard C" first="Corinne" last="Miceli-Richard">Corinne Miceli-Richard</name><affiliation><nlm:aff id="A22">Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France</nlm:aff></affiliation></author><author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C." last="Keystone">Edward C. Keystone</name><affiliation><nlm:aff id="A23">Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario</nlm:aff></affiliation></author><author><name sortKey="Bykerk, Vivian P" sort="Bykerk, Vivian P" uniqKey="Bykerk V" first="Vivian P." last="Bykerk">Vivian P. Bykerk</name><affiliation><nlm:aff id="A24">Hospital for Special Surgery, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Hirschfield, Gideon" sort="Hirschfield, Gideon" uniqKey="Hirschfield G" first="Gideon" last="Hirschfield">Gideon Hirschfield</name><affiliation><nlm:aff id="A25">NIHR Biomedical Research Unit, University of Birmingham, Birmingham, UK</nlm:aff></affiliation></author><author><name sortKey="Xie, Gang" sort="Xie, Gang" uniqKey="Xie G" first="Gang" last="Xie">Gang Xie</name><affiliation><nlm:aff id="A26">Samuel Lunenfeld and Toronto General Research Institutes, Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Toronto Ontario</nlm:aff></affiliation></author><author><name sortKey="Ng, Wan Fai" sort="Ng, Wan Fai" uniqKey="Ng W" first="Wan-Fai" last="Ng">Wan-Fai Ng</name><affiliation><nlm:aff id="A27">Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Nordmark, Gunnel" sort="Nordmark, Gunnel" uniqKey="Nordmark G" first="Gunnel" last="Nordmark">Gunnel Nordmark</name><affiliation><nlm:aff id="A28">Section of Rheumatology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Bucher, Sara Magnusson" sort="Bucher, Sara Magnusson" uniqKey="Bucher S" first="Sara Magnusson" last="Bucher">Sara Magnusson Bucher</name><affiliation><nlm:aff id="A29">Department of Rheumatology, Örebro University Hospital, Örebro, Sweden</nlm:aff></affiliation></author><author><name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name><affiliation><nlm:aff id="A30">Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</nlm:aff></affiliation></author><author><name sortKey="Omdal, Roald" sort="Omdal, Roald" uniqKey="Omdal R" first="Roald" last="Omdal">Roald Omdal</name><affiliation><nlm:aff id="A31">Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway</nlm:aff></affiliation></author><author><name sortKey="Rhodus, Nelson L" sort="Rhodus, Nelson L" uniqKey="Rhodus N" first="Nelson L." last="Rhodus">Nelson L. Rhodus</name><affiliation><nlm:aff id="A32">Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, USA</nlm:aff></affiliation></author><author><name sortKey="Rischmueller, Maureen" sort="Rischmueller, Maureen" uniqKey="Rischmueller M" first="Maureen" last="Rischmueller">Maureen Rischmueller</name><affiliation><nlm:aff id="A33">Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Discipline of Medicine, University of Adelaide, Adelaide, SA 5000, Australia</nlm:aff></affiliation></author><author><name sortKey="Rohrer, Michael" sort="Rohrer, Michael" uniqKey="Rohrer M" first="Michael" last="Rohrer">Michael Rohrer</name><affiliation><nlm:aff id="A14">Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Wahren Herlenius, Marie" sort="Wahren Herlenius, Marie" uniqKey="Wahren Herlenius M" first="Marie" last="Wahren-Herlenius">Marie Wahren-Herlenius</name><affiliation><nlm:aff id="A35">Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Witte, Torsten" sort="Witte, Torsten" uniqKey="Witte T" first="Torsten" last="Witte">Torsten Witte</name><affiliation><nlm:aff id="A36">Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation><nlm:aff id="A22">Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France</nlm:aff></affiliation></author><author><name sortKey="Lessard, Christopher J" sort="Lessard, Christopher J" uniqKey="Lessard C" first="Christopher J." last="Lessard">Christopher J. Lessard</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Harley, John B" sort="Harley, John B" uniqKey="Harley J" first="John B" last="Harley">John B. Harley</name><affiliation><nlm:aff id="A5">Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Medical Service, Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA</nlm:aff></affiliation></author><author><name sortKey="Sivils, Kathy L" sort="Sivils, Kathy L" uniqKey="Sivils K" first="Kathy L" last="Sivils">Kathy L. Sivils</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Scofield, R Hal" sort="Scofield, R Hal" uniqKey="Scofield R" first="R. Hal" last="Scofield">R. Hal Scofield</name><affiliation><nlm:aff id="A1">Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Clinical immunology (Orlando, Fla.)</title><idno type="ISSN">1521-6616</idno><idno type="eISSN">1521-7035</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Primary Sjögren's syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelter's syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47,XXY, p=0.0012 by Fisher's exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fisher's exact test p=NS). These results are consistent with the hypothesis that the number of X chromosomes is critical for the female bias of pSS, a property that may be shared with SLE but not RA.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100883537</journal-id><journal-id journal-id-type="pubmed-jr-id">21167</journal-id><journal-id journal-id-type="nlm-ta">Clin Immunol</journal-id><journal-id journal-id-type="iso-abbrev">Clin. Immunol.</journal-id><journal-title-group><journal-title>Clinical immunology (Orlando, Fla.)</journal-title></journal-title-group><issn pub-type="ppub">1521-6616</issn><issn pub-type="epub">1521-7035</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27109640</article-id><article-id pub-id-type="pmc">4940221</article-id><article-id pub-id-type="doi">10.1016/j.clim.2016.04.002</article-id><article-id pub-id-type="manuscript">NIHMS785176</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Harris</surname><given-names>Valerie M.</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Sharma</surname><given-names>Rohan</given-names></name><degrees>MBBS</degrees><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Cavett</surname><given-names>Joshua</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Kurien</surname><given-names>Biji T.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Ke</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Koelsch</surname><given-names>Kristi A.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Rasmussen</surname><given-names>Astrid</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Radfar</surname><given-names>Lida</given-names></name><degrees>DDS</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Lewis</surname><given-names>David</given-names></name><degrees>DDS</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Stone</surname><given-names>Donald U.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Kaufman</surname><given-names>C. Erick</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Shibo</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Segal</surname><given-names>Barbara</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Wallace</surname><given-names>Daniel J</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Weisman</surname><given-names>Michael H.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Venuturupalli</surname><given-names>Swamy</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Kelly</surname><given-names>Jennifer A.</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Alarcon-Riquelme</surname><given-names>Marta E.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Pons-Estel</surname><given-names>Bernardo</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Jonsson</surname><given-names>Roland</given-names></name><degrees>DMD, PhD</degrees><xref ref-type="aff" rid="A15">15</xref><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>Xianglan</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Gottenberg</surname><given-names>Jacques-Eric</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A17">18</xref></contrib><contrib contrib-type="author"><name><surname>Anaya</surname><given-names>Juan-Manuel</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A18">19</xref></contrib><contrib contrib-type="author"><name><surname>Cunninghame-Graham</surname><given-names>Deborah S.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A19">20</xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Andrew J. W.</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Brennan</surname><given-names>Michael T.</given-names></name><degrees>DDS, MHS</degrees><xref ref-type="aff" rid="A20">21</xref></contrib><contrib contrib-type="author"><name><surname>Hughes</surname><given-names>Pamela</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Alevizos</surname><given-names>Ilias</given-names></name><degrees>DMD, MMSc</degrees><xref ref-type="aff" rid="A21">22</xref></contrib><contrib contrib-type="author"><name><surname>Miceli-Richard</surname><given-names>Corinne</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A22">23</xref></contrib><contrib contrib-type="author"><name><surname>Keystone</surname><given-names>Edward C.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A23">24</xref></contrib><contrib contrib-type="author"><name><surname>Bykerk</surname><given-names>Vivian P.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A24">25</xref></contrib><contrib contrib-type="author"><name><surname>Hirschfield</surname><given-names>Gideon</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A25">26</xref></contrib><contrib contrib-type="author"><name><surname>Xie</surname><given-names>Gang</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A26">27</xref></contrib><contrib contrib-type="author"><name><surname>Ng</surname><given-names>Wan-Fai</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A27">28</xref></contrib><contrib contrib-type="author"><name><surname>Nordmark</surname><given-names>Gunnel</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A28">29</xref></contrib><contrib contrib-type="author"><name><surname>Bucher</surname><given-names>Sara Magnusson</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A29">30</xref></contrib><contrib contrib-type="author"><name><surname>Eriksson</surname><given-names>Per</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A30">31</xref></contrib><contrib contrib-type="author"><name><surname>Omdal</surname><given-names>Roald</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A31">32</xref></contrib><contrib contrib-type="author"><name><surname>Rhodus</surname><given-names>Nelson L.</given-names></name><degrees>MPH, DDS</degrees><xref ref-type="aff" rid="A32">33</xref></contrib><contrib contrib-type="author"><name><surname>Rischmueller</surname><given-names>Maureen</given-names></name><degrees>MBBS</degrees><xref ref-type="aff" rid="A33">34</xref><xref ref-type="aff" rid="A34">35</xref></contrib><contrib contrib-type="author"><name><surname>Rohrer</surname><given-names>Michael</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Wahren-Herlenius</surname><given-names>Marie</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A35">36</xref></contrib><contrib contrib-type="author"><name><surname>Witte</surname><given-names>Torsten</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A36">37</xref></contrib><contrib contrib-type="author"><name><surname>Mariette</surname><given-names>Xavier</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A22">23</xref></contrib><contrib contrib-type="author"><name><surname>Lessard</surname><given-names>Christopher J.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Harley</surname><given-names>John B</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A37">38</xref></contrib><contrib contrib-type="author"><name><surname>Sivils</surname><given-names>Kathy L</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Scofield</surname><given-names>R. Hal</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib></contrib-group><aff id="A1"><label>1</label>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA</aff><aff id="A2"><label>2</label>Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</aff><aff id="A3"><label>3</label>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA</aff><aff id="A4"><label>4</label>Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA</aff><aff id="A5"><label>5</label>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</aff><aff id="A6"><label>6</label>College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA</aff><aff id="A7"><label>7</label>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA</aff><aff id="A8"><label>8</label>Dean McGee Eye Institute and Department of Ophthalmology, University of Oklahoma College of Medicine, Oklahoma City, OK, USA</aff><aff id="A9"><label>9</label>Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA</aff><aff id="A10"><label>10</label>Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA</aff><aff id="A11"><label>11</label>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</aff><aff id="A12"><label>12</label>Center Pfizer, University of Granada, Andalusian Government for Genomics and Oncological Research, PTS Granada, 18016, Spain</aff><aff id="A13"><label>13</label>Sanatorio Parque, Rosario, Argentina</aff><aff id="A14"><label>14</label>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA</aff><aff id="A15"><label>15</label>Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021, Norway</aff><aff id="A16"><label>16</label>Department of Rheumatology, Haukeland University Hospital, Bergen 5021, Norway</aff><aff id="A17"><label>18</label>Strasbourg University, Strasbourg, France</aff><aff id="A18"><label>19</label>Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia</aff><aff id="A19"><label>20</label>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, UK</aff><aff id="A20"><label>21</label>Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA</aff><aff id="A21"><label>22</label>Molecular Physiology & Therapeutic Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA</aff><aff id="A22"><label>23</label>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France</aff><aff id="A23"><label>24</label>Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario</aff><aff id="A24"><label>25</label>Hospital for Special Surgery, New York, USA</aff><aff id="A25"><label>26</label>NIHR Biomedical Research Unit, University of Birmingham, Birmingham, UK</aff><aff id="A26"><label>27</label>Samuel Lunenfeld and Toronto General Research Institutes, Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Toronto Ontario</aff><aff id="A27"><label>28</label>Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom</aff><aff id="A28"><label>29</label>Section of Rheumatology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden</aff><aff id="A29"><label>30</label>Department of Rheumatology, Örebro University Hospital, Örebro, Sweden</aff><aff id="A30"><label>31</label>Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</aff><aff id="A31"><label>32</label>Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway</aff><aff id="A32"><label>33</label>Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, USA</aff><aff id="A33"><label>34</label>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia</aff><aff id="A34"><label>35</label>Discipline of Medicine, University of Adelaide, Adelaide, SA 5000, Australia</aff><aff id="A35"><label>36</label>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A36"><label>37</label>Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany</aff><aff id="A37"><label>38</label>Medical Service, Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA</aff><author-notes><corresp id="FN1">Correspondence to: Hal Scofield, MD, 825 NE 13<sup>th</sup> Street, Oklahoma City, OK USA 73104, <email>hal-scofield@omrf.ouhsc.edu</email>, Phone +1 405 271 7774, Fax +1 405 271 4110</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>18</day><month>5</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>22</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>7</month><year>2017</year></pub-date><volume>168</volume><fpage>25</fpage><lpage>29</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.clim.2016.04.002</pmc-comment>
<abstract><p id="P1">Primary Sjögren's syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelter's syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47,XXY, p=0.0012 by Fisher's exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fisher's exact test p=NS). These results are consistent with the hypothesis that the number of X chromosomes is critical for the female bias of pSS, a property that may be shared with SLE but not RA.</p></abstract><kwd-group><kwd>Sjögren's syndrome</kwd><kwd>X chromosome</kwd><kwd>Klinefelter's syndrome</kwd><kwd>sex bias</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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