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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">High Deformability of <italic>Plasmodium vivax</italic>–Infected Red Blood Cells under Microfluidic Conditions</title><author><name sortKey="Handayani, Sarwo" sort="Handayani, Sarwo" uniqKey="Handayani S" first="Sarwo" last="Handayani">Sarwo Handayani</name><affiliation><nlm:aff id="A1">National Institute of Health Research and Development, Ministry of Health, Jakarta</nlm:aff></affiliation></author><author><name sortKey="Chiu, Daniel T" sort="Chiu, Daniel T" uniqKey="Chiu D" first="Daniel T." last="Chiu">Daniel T. Chiu</name><affiliation><nlm:aff id="A9">Department of Chemistry, University of Washington, Seattle</nlm:aff></affiliation></author><author><name sortKey="Tjitra, Emiliana" sort="Tjitra, Emiliana" uniqKey="Tjitra E" first="Emiliana" last="Tjitra">Emiliana Tjitra</name><affiliation><nlm:aff id="A1">National Institute of Health Research and Development, Ministry of Health, Jakarta</nlm:aff></affiliation></author><author><name sortKey="Kuo, Jason S" sort="Kuo, Jason S" uniqKey="Kuo J" first="Jason S." last="Kuo">Jason S. Kuo</name><affiliation><nlm:aff id="A9">Department of Chemistry, University of Washington, Seattle</nlm:aff></affiliation></author><author><name sortKey="Lampah, Daniel" sort="Lampah, Daniel" uniqKey="Lampah D" first="Daniel" last="Lampah">Daniel Lampah</name><affiliation><nlm:aff id="A1">National Institute of Health Research and Development, Ministry of Health, Jakarta</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Menzies School of Health Research–National Institute of Health Research and Development Research Program and District Ministry of Health, Timika, Papua, Indonesia</nlm:aff></affiliation></author><author><name sortKey="Kenangalem, Enny" sort="Kenangalem, Enny" uniqKey="Kenangalem E" first="Enny" last="Kenangalem">Enny Kenangalem</name><affiliation><nlm:aff id="A1">National Institute of Health Research and Development, Ministry of Health, Jakarta</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Menzies School of Health Research–National Institute of Health Research and Development Research Program and District Ministry of Health, Timika, Papua, Indonesia</nlm:aff></affiliation></author><author><name sortKey="Renia, Laurent" sort="Renia, Laurent" uniqKey="Renia L" first="Laurent" last="Renia">Laurent Renia</name><affiliation><nlm:aff id="A3">Laboratory of Malaria Immunobiology, Singapore Immunology Network, Biopolis, Agency for Science Technology and Research (A*STAR)</nlm:aff></affiliation></author><author><name sortKey="Snounou, Georges" sort="Snounou, Georges" uniqKey="Snounou G" first="Georges" last="Snounou">Georges Snounou</name><affiliation><nlm:aff id="A4">Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Faculty of Medicine, National University of Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A5">INSERM Unité 511, Département de Parasitologie, Hôpital Pitié-Salpêtrière</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Université Pierre et Marie Curie, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Price, Ric N" sort="Price, Ric N" uniqKey="Price R" first="Ric N." last="Price">Ric N. Price</name><affiliation><nlm:aff id="A7">Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Oxford, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A8">International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia</nlm:aff></affiliation></author><author><name sortKey="Anstey, Nicholas M" sort="Anstey, Nicholas M" uniqKey="Anstey N" first="Nicholas M." last="Anstey">Nicholas M. Anstey</name><affiliation><nlm:aff id="A8">International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia</nlm:aff></affiliation></author><author><name sortKey="Russell, Bruce" sort="Russell, Bruce" uniqKey="Russell B" first="Bruce" last="Russell">Bruce Russell</name><affiliation><nlm:aff id="A3">Laboratory of Malaria Immunobiology, Singapore Immunology Network, Biopolis, Agency for Science Technology and Research (A*STAR)</nlm:aff></affiliation><affiliation><nlm:aff id="A8">International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19090777</idno><idno type="pmc">4337984</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337984</idno><idno type="RBID">PMC:4337984</idno><idno type="doi">10.1086/596048</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">001D51</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D51</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">High Deformability of <italic>Plasmodium vivax</italic>–Infected Red Blood Cells under Microfluidic Conditions</title><author><name sortKey="Handayani, Sarwo" sort="Handayani, Sarwo" uniqKey="Handayani S" first="Sarwo" last="Handayani">Sarwo Handayani</name><affiliation><nlm:aff id="A1">National Institute of Health Research and Development, Ministry of Health, Jakarta</nlm:aff></affiliation></author><author><name sortKey="Chiu, Daniel T" sort="Chiu, Daniel T" uniqKey="Chiu D" first="Daniel T." last="Chiu">Daniel T. Chiu</name><affiliation><nlm:aff id="A9">Department of Chemistry, University of Washington, Seattle</nlm:aff></affiliation></author><author><name sortKey="Tjitra, Emiliana" sort="Tjitra, Emiliana" uniqKey="Tjitra E" first="Emiliana" last="Tjitra">Emiliana Tjitra</name><affiliation><nlm:aff id="A1">National Institute of Health Research and Development, Ministry of Health, Jakarta</nlm:aff></affiliation></author><author><name sortKey="Kuo, Jason S" sort="Kuo, Jason S" uniqKey="Kuo J" first="Jason S." last="Kuo">Jason S. Kuo</name><affiliation><nlm:aff id="A9">Department of Chemistry, University of Washington, Seattle</nlm:aff></affiliation></author><author><name sortKey="Lampah, Daniel" sort="Lampah, Daniel" uniqKey="Lampah D" first="Daniel" last="Lampah">Daniel Lampah</name><affiliation><nlm:aff id="A1">National Institute of Health Research and Development, Ministry of Health, Jakarta</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Menzies School of Health Research–National Institute of Health Research and Development Research Program and District Ministry of Health, Timika, Papua, Indonesia</nlm:aff></affiliation></author><author><name sortKey="Kenangalem, Enny" sort="Kenangalem, Enny" uniqKey="Kenangalem E" first="Enny" last="Kenangalem">Enny Kenangalem</name><affiliation><nlm:aff id="A1">National Institute of Health Research and Development, Ministry of Health, Jakarta</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Menzies School of Health Research–National Institute of Health Research and Development Research Program and District Ministry of Health, Timika, Papua, Indonesia</nlm:aff></affiliation></author><author><name sortKey="Renia, Laurent" sort="Renia, Laurent" uniqKey="Renia L" first="Laurent" last="Renia">Laurent Renia</name><affiliation><nlm:aff id="A3">Laboratory of Malaria Immunobiology, Singapore Immunology Network, Biopolis, Agency for Science Technology and Research (A*STAR)</nlm:aff></affiliation></author><author><name sortKey="Snounou, Georges" sort="Snounou, Georges" uniqKey="Snounou G" first="Georges" last="Snounou">Georges Snounou</name><affiliation><nlm:aff id="A4">Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Faculty of Medicine, National University of Singapore, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A5">INSERM Unité 511, Département de Parasitologie, Hôpital Pitié-Salpêtrière</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Université Pierre et Marie Curie, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Price, Ric N" sort="Price, Ric N" uniqKey="Price R" first="Ric N." last="Price">Ric N. Price</name><affiliation><nlm:aff id="A7">Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Oxford, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A8">International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia</nlm:aff></affiliation></author><author><name sortKey="Anstey, Nicholas M" sort="Anstey, Nicholas M" uniqKey="Anstey N" first="Nicholas M." last="Anstey">Nicholas M. Anstey</name><affiliation><nlm:aff id="A8">International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia</nlm:aff></affiliation></author><author><name sortKey="Russell, Bruce" sort="Russell, Bruce" uniqKey="Russell B" first="Bruce" last="Russell">Bruce Russell</name><affiliation><nlm:aff id="A3">Laboratory of Malaria Immunobiology, Singapore Immunology Network, Biopolis, Agency for Science Technology and Research (A*STAR)</nlm:aff></affiliation><affiliation><nlm:aff id="A8">International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia</nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Maturation of <italic>Plasmodium falciparum</italic> decreases the deformability of infected red blood cells (RBCs), increasing their clearance as they attempt to pass through endothelial slits of the splenic sinus. Previous studies of <italic>Plasmodium vivax</italic>–infected RBCs led to opposite conclusions with respect to cellular deformability. To resolve this controversy, <italic>P. vivax</italic>–infected RBCs were passed through a 2-<italic>μ</italic>m microfluidic channel. In contrast to <italic>P. falciparum</italic>–infected RBCs, mature <italic>P. vivax</italic>–infected RBCs readily became deformed through 2-<italic>μ</italic>m constrictions. After this extreme deformation, 67% of <italic>P.vivax</italic>–infected RBCs, recovered a normal appearance; however, 15% of uninfected RBCs were destroyed. Results suggest mechanisms for both avoidance of splenic clearance and anemia in vivax malaria.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0413675</journal-id><journal-id journal-id-type="pubmed-jr-id">4830</journal-id><journal-id journal-id-type="nlm-ta">J Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">J. Infect. Dis.</journal-id><journal-title-group><journal-title>The Journal of infectious diseases</journal-title></journal-title-group><issn pub-type="ppub">0022-1899</issn><issn pub-type="epub">1537-6613</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19090777</article-id><article-id pub-id-type="pmc">4337984</article-id><article-id pub-id-type="doi">10.1086/596048</article-id><article-id pub-id-type="manuscript">EMS62035</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>High Deformability of <italic>Plasmodium vivax</italic>–Infected Red Blood Cells under Microfluidic Conditions</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Handayani</surname><given-names>Sarwo</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chiu</surname><given-names>Daniel T.</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Tjitra</surname><given-names>Emiliana</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kuo</surname><given-names>Jason S.</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Lampah</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Kenangalem</surname><given-names>Enny</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Renia</surname><given-names>Laurent</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Snounou</surname><given-names>Georges</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Price</surname><given-names>Ric N.</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Anstey</surname><given-names>Nicholas M.</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Russell</surname><given-names>Bruce</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A8">8</xref></contrib></contrib-group><aff id="A1"><label>1</label>National Institute of Health Research and Development, Ministry of Health, Jakarta</aff><aff id="A2"><label>2</label>Menzies School of Health Research–National Institute of Health Research and Development Research Program and District Ministry of Health, Timika, Papua, Indonesia</aff><aff id="A3"><label>3</label>Laboratory of Malaria Immunobiology, Singapore Immunology Network, Biopolis, Agency for Science Technology and Research (A*STAR)</aff><aff id="A4"><label>4</label>Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Faculty of Medicine, National University of Singapore, Singapore</aff><aff id="A5"><label>5</label>INSERM Unité 511, Département de Parasitologie, Hôpital Pitié-Salpêtrière</aff><aff id="A6"><label>6</label>Université Pierre et Marie Curie, Paris, France</aff><aff id="A7"><label>7</label>Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Oxford, United Kingdom</aff><aff id="A8"><label>8</label>International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia</aff><aff id="A9"><label>9</label>Department of Chemistry, University of Washington, Seattle</aff><author-notes><corresp id="CR1">Reprints or correspondence: Dr. Bruce Russell, Laboratory of Malaria Immunology, Singapore Immunology Network, 8A Biomedical Grove, #03-06 Immunos, Singapore 138648 (<email>bruce_russell@immunol.a-star.edu.au</email>)</corresp><fn id="FN2"><p id="P1">B.R. conceived and designed the experiments. S.H. and B.R. performed the experiments. S.H. and B.R. analyzed the data. D.T.C., E.T., J.S.K., D.L., E.K., G.S., L.R., R.N.P., and N.M.A. contributed reagents, materials, and analysis tools. G.S., S.H., D.T.C., E.T., J.S.K., L.R., R.N.P., N.M.A., and B.R. wrote the article.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>29</day><month>1</month><year>2015</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>2</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>23</day><month>2</month><year>2015</year></pub-date><volume>199</volume><issue>3</issue><fpage>445</fpage><lpage>450</lpage><pmc-comment>elocation-id from pubmed: 10.1086/596048</pmc-comment>
<permissions><copyright-statement>© 2008 by the Infectious Diseases Society of America. All rights reserved.</copyright-statement><copyright-year>2008</copyright-year></permissions><abstract><p id="P2">Maturation of <italic>Plasmodium falciparum</italic> decreases the deformability of infected red blood cells (RBCs), increasing their clearance as they attempt to pass through endothelial slits of the splenic sinus. Previous studies of <italic>Plasmodium vivax</italic>–infected RBCs led to opposite conclusions with respect to cellular deformability. To resolve this controversy, <italic>P. vivax</italic>–infected RBCs were passed through a 2-<italic>μ</italic>m microfluidic channel. In contrast to <italic>P. falciparum</italic>–infected RBCs, mature <italic>P. vivax</italic>–infected RBCs readily became deformed through 2-<italic>μ</italic>m constrictions. After this extreme deformation, 67% of <italic>P.vivax</italic>–infected RBCs, recovered a normal appearance; however, 15% of uninfected RBCs were destroyed. Results suggest mechanisms for both avoidance of splenic clearance and anemia in vivax malaria.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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