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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Aryl hydrocarbon receptor control of a disease tolerance defense pathway</title><author><name sortKey="Bessede, Alban" sort="Bessede, Alban" uniqKey="Bessede A" first="Alban" last="Bessede">Alban Bessede</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A2">University of Bordeaux, IMS Laboratory, Pessac, France</nlm:aff></affiliation></author><author><name sortKey="Gargaro, Marco" sort="Gargaro, Marco" uniqKey="Gargaro M" first="Marco" last="Gargaro">Marco Gargaro</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Pallotta, Maria T" sort="Pallotta, Maria T" uniqKey="Pallotta M" first="Maria T" last="Pallotta">Maria T. Pallotta</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Matino, Davide" sort="Matino, Davide" uniqKey="Matino D" first="Davide" last="Matino">Davide Matino</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Servillo, Giuseppe" sort="Servillo, Giuseppe" uniqKey="Servillo G" first="Giuseppe" last="Servillo">Giuseppe Servillo</name><affiliation><nlm:aff id="A3">Department of Clinical and Experimental Medicine, University of Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Brunacci, Cinzia" sort="Brunacci, Cinzia" uniqKey="Brunacci C" first="Cinzia" last="Brunacci">Cinzia Brunacci</name><affiliation><nlm:aff id="A3">Department of Clinical and Experimental Medicine, University of Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Bicciato, Silvio" sort="Bicciato, Silvio" uniqKey="Bicciato S" first="Silvio" last="Bicciato">Silvio Bicciato</name><affiliation><nlm:aff id="A4">Center for Genome Research, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy</nlm:aff></affiliation></author><author><name sortKey="Mazza, Emilia Mc" sort="Mazza, Emilia Mc" uniqKey="Mazza E" first="Emilia Mc" last="Mazza">Emilia Mc Mazza</name><affiliation><nlm:aff id="A4">Center for Genome Research, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy</nlm:aff></affiliation></author><author><name sortKey="Macchiarulo, Antonio" sort="Macchiarulo, Antonio" uniqKey="Macchiarulo A" first="Antonio" last="Macchiarulo">Antonio Macchiarulo</name><affiliation><nlm:aff id="A5">Department of Chemistry and Technology of Drugs, University of Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Vacca, Carmine" sort="Vacca, Carmine" uniqKey="Vacca C" first="Carmine" last="Vacca">Carmine Vacca</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Iannitti, Rossana" sort="Iannitti, Rossana" uniqKey="Iannitti R" first="Rossana" last="Iannitti">Rossana Iannitti</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Tissi, Luciana" sort="Tissi, Luciana" uniqKey="Tissi L" first="Luciana" last="Tissi">Luciana Tissi</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Volpi, Claudia" sort="Volpi, Claudia" uniqKey="Volpi C" first="Claudia" last="Volpi">Claudia Volpi</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Belladonna, Maria L" sort="Belladonna, Maria L" uniqKey="Belladonna M" first="Maria L" last="Belladonna">Maria L. Belladonna</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Orabona, Ciriana" sort="Orabona, Ciriana" uniqKey="Orabona C" first="Ciriana" last="Orabona">Ciriana Orabona</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Bianchi, Roberta" sort="Bianchi, Roberta" uniqKey="Bianchi R" first="Roberta" last="Bianchi">Roberta Bianchi</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Lanz, Tobias" sort="Lanz, Tobias" uniqKey="Lanz T" first="Tobias" last="Lanz">Tobias Lanz</name><affiliation><nlm:aff id="A6">Experimental Neuroimmunology Unit, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Department of Neurooncology, University Hospital, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Platten, Michael" sort="Platten, Michael" uniqKey="Platten M" first="Michael" last="Platten">Michael Platten</name><affiliation><nlm:aff id="A6">Experimental Neuroimmunology Unit, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Department of Neurooncology, University Hospital, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Fazia, Maria A Della" sort="Fazia, Maria A Della" uniqKey="Fazia M" first="Maria A Della" last="Fazia">Maria A Della Fazia</name><affiliation><nlm:aff id="A3">Department of Clinical and Experimental Medicine, University of Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Piobbico, Danilo" sort="Piobbico, Danilo" uniqKey="Piobbico D" first="Danilo" last="Piobbico">Danilo Piobbico</name><affiliation><nlm:aff id="A3">Department of Clinical and Experimental Medicine, University of Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Zelante, Teresa" sort="Zelante, Teresa" uniqKey="Zelante T" first="Teresa" last="Zelante">Teresa Zelante</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Funakoshi, Hiroshi" sort="Funakoshi, Hiroshi" uniqKey="Funakoshi H" first="Hiroshi" last="Funakoshi">Hiroshi Funakoshi</name><affiliation><nlm:aff id="A8">Center for Advanced Research and Education, Asahikawa Medical University, Asahikawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Nakamura, Toshikazu" sort="Nakamura, Toshikazu" uniqKey="Nakamura T" first="Toshikazu" last="Nakamura">Toshikazu Nakamura</name><affiliation><nlm:aff id="A9">Kringle Pharma Joint Research Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University, Osaka, Japan</nlm:aff></affiliation></author><author><name sortKey="Gilot, David" sort="Gilot, David" uniqKey="Gilot D" first="David" last="Gilot">David Gilot</name><affiliation><nlm:aff id="A10">4CNRS UMR 6290, Université de Rennes, Rennes, France</nlm:aff></affiliation></author><author><name sortKey="Denison, Michael S" sort="Denison, Michael S" uniqKey="Denison M" first="Michael S" last="Denison">Michael S. Denison</name><affiliation><nlm:aff id="A11">Department of Environmental Toxicology, University of California, Davis, CA</nlm:aff></affiliation></author><author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J" last="Guillemin">Gilles J. Guillemin</name><affiliation><nlm:aff id="A12">Australian School of Advanced Medicine (ASAM), Macquarie University, NSW, 2109, Australia</nlm:aff></affiliation></author><author><name sortKey="Duhadaway, James B" sort="Duhadaway, James B" uniqKey="Duhadaway J" first="James B" last="Duhadaway">James B. Duhadaway</name><affiliation><nlm:aff id="A13">Lankenau Institute for Medical Research, Wynnewood, PA</nlm:aff></affiliation></author><author><name sortKey="Prendergast, George C" sort="Prendergast, George C" uniqKey="Prendergast G" first="George C" last="Prendergast">George C. Prendergast</name><affiliation><nlm:aff id="A13">Lankenau Institute for Medical Research, Wynnewood, PA</nlm:aff></affiliation></author><author><name sortKey="Metz, Richard" sort="Metz, Richard" uniqKey="Metz R" first="Richard" last="Metz">Richard Metz</name><affiliation><nlm:aff id="A14">New Link Genetics Corporation, Ames, IA</nlm:aff></affiliation></author><author><name sortKey="Geffard, Michel" sort="Geffard, Michel" uniqKey="Geffard M" first="Michel" last="Geffard">Michel Geffard</name><affiliation><nlm:aff id="A2">University of Bordeaux, IMS Laboratory, Pessac, France</nlm:aff></affiliation></author><author><name sortKey="Boon, Louis" sort="Boon, Louis" uniqKey="Boon L" first="Louis" last="Boon">Louis Boon</name><affiliation><nlm:aff id="A15">Bioceros, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pirro, Matteo" sort="Pirro, Matteo" uniqKey="Pirro M" first="Matteo" last="Pirro">Matteo Pirro</name><affiliation><nlm:aff id="A16">Department of Clinical and Experimental Medicine, University of Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Iorio, Alfonso" sort="Iorio, Alfonso" uniqKey="Iorio A" first="Alfonso" last="Iorio">Alfonso Iorio</name><affiliation><nlm:aff id="A17">Clinical Epidemiology and Biostatistics and Medicine, McMaster University, Canada</nlm:aff></affiliation></author><author><name sortKey="Veyret, Bernard" sort="Veyret, Bernard" uniqKey="Veyret B" first="Bernard" last="Veyret">Bernard Veyret</name><affiliation><nlm:aff id="A2">University of Bordeaux, IMS Laboratory, Pessac, France</nlm:aff></affiliation></author><author><name sortKey="Romani, Luigina" sort="Romani, Luigina" uniqKey="Romani L" first="Luigina" last="Romani">Luigina Romani</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Grohmann, Ursula" sort="Grohmann, Ursula" uniqKey="Grohmann U" first="Ursula" last="Grohmann">Ursula Grohmann</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Fallarino, Francesca" sort="Fallarino, Francesca" uniqKey="Fallarino F" first="Francesca" last="Fallarino">Francesca Fallarino</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Puccetti, Paolo" sort="Puccetti, Paolo" uniqKey="Puccetti P" first="Paolo" last="Puccetti">Paolo Puccetti</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24930766</idno><idno type="pmc">4098076</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098076</idno><idno type="RBID">PMC:4098076</idno><idno type="doi">10.1038/nature13323</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001D36</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D36</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Aryl hydrocarbon receptor control of a disease tolerance defense pathway</title><author><name sortKey="Bessede, Alban" sort="Bessede, Alban" uniqKey="Bessede A" first="Alban" last="Bessede">Alban Bessede</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A2">University of Bordeaux, IMS Laboratory, Pessac, France</nlm:aff></affiliation></author><author><name sortKey="Gargaro, Marco" sort="Gargaro, Marco" uniqKey="Gargaro M" first="Marco" last="Gargaro">Marco Gargaro</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Pallotta, Maria T" sort="Pallotta, Maria T" uniqKey="Pallotta M" first="Maria T" last="Pallotta">Maria T. Pallotta</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Matino, Davide" sort="Matino, Davide" uniqKey="Matino D" first="Davide" last="Matino">Davide Matino</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Servillo, Giuseppe" sort="Servillo, Giuseppe" uniqKey="Servillo G" first="Giuseppe" last="Servillo">Giuseppe Servillo</name><affiliation><nlm:aff id="A3">Department of Clinical and Experimental Medicine, University of Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Brunacci, Cinzia" sort="Brunacci, Cinzia" uniqKey="Brunacci C" first="Cinzia" last="Brunacci">Cinzia Brunacci</name><affiliation><nlm:aff id="A3">Department of Clinical and Experimental Medicine, University of Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Bicciato, Silvio" sort="Bicciato, Silvio" uniqKey="Bicciato S" first="Silvio" last="Bicciato">Silvio Bicciato</name><affiliation><nlm:aff id="A4">Center for Genome Research, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy</nlm:aff></affiliation></author><author><name sortKey="Mazza, Emilia Mc" sort="Mazza, Emilia Mc" uniqKey="Mazza E" first="Emilia Mc" last="Mazza">Emilia Mc Mazza</name><affiliation><nlm:aff id="A4">Center for Genome Research, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy</nlm:aff></affiliation></author><author><name sortKey="Macchiarulo, Antonio" sort="Macchiarulo, Antonio" uniqKey="Macchiarulo A" first="Antonio" last="Macchiarulo">Antonio Macchiarulo</name><affiliation><nlm:aff id="A5">Department of Chemistry and Technology of Drugs, University of Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Vacca, Carmine" sort="Vacca, Carmine" uniqKey="Vacca C" first="Carmine" last="Vacca">Carmine Vacca</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Iannitti, Rossana" sort="Iannitti, Rossana" uniqKey="Iannitti R" first="Rossana" last="Iannitti">Rossana Iannitti</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Tissi, Luciana" sort="Tissi, Luciana" uniqKey="Tissi L" first="Luciana" last="Tissi">Luciana Tissi</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Volpi, Claudia" sort="Volpi, Claudia" uniqKey="Volpi C" first="Claudia" last="Volpi">Claudia Volpi</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Belladonna, Maria L" sort="Belladonna, Maria L" uniqKey="Belladonna M" first="Maria L" last="Belladonna">Maria L. Belladonna</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Orabona, Ciriana" sort="Orabona, Ciriana" uniqKey="Orabona C" first="Ciriana" last="Orabona">Ciriana Orabona</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Bianchi, Roberta" sort="Bianchi, Roberta" uniqKey="Bianchi R" first="Roberta" last="Bianchi">Roberta Bianchi</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Lanz, Tobias" sort="Lanz, Tobias" uniqKey="Lanz T" first="Tobias" last="Lanz">Tobias Lanz</name><affiliation><nlm:aff id="A6">Experimental Neuroimmunology Unit, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Department of Neurooncology, University Hospital, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Platten, Michael" sort="Platten, Michael" uniqKey="Platten M" first="Michael" last="Platten">Michael Platten</name><affiliation><nlm:aff id="A6">Experimental Neuroimmunology Unit, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Department of Neurooncology, University Hospital, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Fazia, Maria A Della" sort="Fazia, Maria A Della" uniqKey="Fazia M" first="Maria A Della" last="Fazia">Maria A Della Fazia</name><affiliation><nlm:aff id="A3">Department of Clinical and Experimental Medicine, University of Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Piobbico, Danilo" sort="Piobbico, Danilo" uniqKey="Piobbico D" first="Danilo" last="Piobbico">Danilo Piobbico</name><affiliation><nlm:aff id="A3">Department of Clinical and Experimental Medicine, University of Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Zelante, Teresa" sort="Zelante, Teresa" uniqKey="Zelante T" first="Teresa" last="Zelante">Teresa Zelante</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Funakoshi, Hiroshi" sort="Funakoshi, Hiroshi" uniqKey="Funakoshi H" first="Hiroshi" last="Funakoshi">Hiroshi Funakoshi</name><affiliation><nlm:aff id="A8">Center for Advanced Research and Education, Asahikawa Medical University, Asahikawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Nakamura, Toshikazu" sort="Nakamura, Toshikazu" uniqKey="Nakamura T" first="Toshikazu" last="Nakamura">Toshikazu Nakamura</name><affiliation><nlm:aff id="A9">Kringle Pharma Joint Research Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University, Osaka, Japan</nlm:aff></affiliation></author><author><name sortKey="Gilot, David" sort="Gilot, David" uniqKey="Gilot D" first="David" last="Gilot">David Gilot</name><affiliation><nlm:aff id="A10">4CNRS UMR 6290, Université de Rennes, Rennes, France</nlm:aff></affiliation></author><author><name sortKey="Denison, Michael S" sort="Denison, Michael S" uniqKey="Denison M" first="Michael S" last="Denison">Michael S. Denison</name><affiliation><nlm:aff id="A11">Department of Environmental Toxicology, University of California, Davis, CA</nlm:aff></affiliation></author><author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J" last="Guillemin">Gilles J. Guillemin</name><affiliation><nlm:aff id="A12">Australian School of Advanced Medicine (ASAM), Macquarie University, NSW, 2109, Australia</nlm:aff></affiliation></author><author><name sortKey="Duhadaway, James B" sort="Duhadaway, James B" uniqKey="Duhadaway J" first="James B" last="Duhadaway">James B. Duhadaway</name><affiliation><nlm:aff id="A13">Lankenau Institute for Medical Research, Wynnewood, PA</nlm:aff></affiliation></author><author><name sortKey="Prendergast, George C" sort="Prendergast, George C" uniqKey="Prendergast G" first="George C" last="Prendergast">George C. Prendergast</name><affiliation><nlm:aff id="A13">Lankenau Institute for Medical Research, Wynnewood, PA</nlm:aff></affiliation></author><author><name sortKey="Metz, Richard" sort="Metz, Richard" uniqKey="Metz R" first="Richard" last="Metz">Richard Metz</name><affiliation><nlm:aff id="A14">New Link Genetics Corporation, Ames, IA</nlm:aff></affiliation></author><author><name sortKey="Geffard, Michel" sort="Geffard, Michel" uniqKey="Geffard M" first="Michel" last="Geffard">Michel Geffard</name><affiliation><nlm:aff id="A2">University of Bordeaux, IMS Laboratory, Pessac, France</nlm:aff></affiliation></author><author><name sortKey="Boon, Louis" sort="Boon, Louis" uniqKey="Boon L" first="Louis" last="Boon">Louis Boon</name><affiliation><nlm:aff id="A15">Bioceros, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pirro, Matteo" sort="Pirro, Matteo" uniqKey="Pirro M" first="Matteo" last="Pirro">Matteo Pirro</name><affiliation><nlm:aff id="A16">Department of Clinical and Experimental Medicine, University of Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Iorio, Alfonso" sort="Iorio, Alfonso" uniqKey="Iorio A" first="Alfonso" last="Iorio">Alfonso Iorio</name><affiliation><nlm:aff id="A17">Clinical Epidemiology and Biostatistics and Medicine, McMaster University, Canada</nlm:aff></affiliation></author><author><name sortKey="Veyret, Bernard" sort="Veyret, Bernard" uniqKey="Veyret B" first="Bernard" last="Veyret">Bernard Veyret</name><affiliation><nlm:aff id="A2">University of Bordeaux, IMS Laboratory, Pessac, France</nlm:aff></affiliation></author><author><name sortKey="Romani, Luigina" sort="Romani, Luigina" uniqKey="Romani L" first="Luigina" last="Romani">Luigina Romani</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Grohmann, Ursula" sort="Grohmann, Ursula" uniqKey="Grohmann U" first="Ursula" last="Grohmann">Ursula Grohmann</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Fallarino, Francesca" sort="Fallarino, Francesca" uniqKey="Fallarino F" first="Francesca" last="Fallarino">Francesca Fallarino</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author><author><name sortKey="Puccetti, Paolo" sort="Puccetti, Paolo" uniqKey="Puccetti P" first="Paolo" last="Puccetti">Paolo Puccetti</name><affiliation><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff></affiliation></author></analytic><series><title level="j">Nature</title><idno type="ISSN">0028-0836</idno><idno type="eISSN">1476-4687</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Summary</title><p id="P2">Disease tolerance is the ability of the host to reduce the impact of infection on host fitness. Analysis of disease tolerance pathways could provide new approaches for treating infections and other inflammatory diseases. Typically, an initial exposure to bacterial lipopolysaccharide (LPS) induces a state of refractoriness to further LPS challenge (“endotoxin tolerance”). We found that a first exposure to LPS activated the ligand-operated transcription factor aryl hydrocarbon receptor (AhR) and the hepatic enzyme tryptophan 2,3-dioxygenase 2, which provided an activating ligand to the former, to downregulate early inflammatory gene expression. However, on LPS rechallenge, AhR engaged in long-term regulation of systemic inflammation only in the presence of indoleamine 2,3-dioxygenase 1 (IDO1). AhR complex-associated Src kinase activity promoted IDO1 phosphorylation and signaling ability. The resulting endotoxin-tolerant state was found to protect mice against immunopathology in gram-negative and gram-positive infections, pointing to a role for AhR in contributing to host fitness.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0410462</journal-id><journal-id journal-id-type="pubmed-jr-id">6011</journal-id><journal-id journal-id-type="nlm-ta">Nature</journal-id><journal-id journal-id-type="iso-abbrev">Nature</journal-id><journal-title-group><journal-title>Nature</journal-title></journal-title-group><issn pub-type="ppub">0028-0836</issn><issn pub-type="epub">1476-4687</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24930766</article-id><article-id pub-id-type="pmc">4098076</article-id><article-id pub-id-type="doi">10.1038/nature13323</article-id><article-id pub-id-type="manuscript">NIHMS611159</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Aryl hydrocarbon receptor control of a disease tolerance defense pathway</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bessede</surname><given-names>Alban</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FN1">17</xref></contrib><contrib contrib-type="author"><name><surname>Gargaro</surname><given-names>Marco</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="author-notes" rid="FN1">17</xref></contrib><contrib contrib-type="author"><name><surname>Pallotta</surname><given-names>Maria T</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Matino</surname><given-names>Davide</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Servillo</surname><given-names>Giuseppe</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Brunacci</surname><given-names>Cinzia</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Bicciato</surname><given-names>Silvio</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Mazza</surname><given-names>Emilia MC</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Macchiarulo</surname><given-names>Antonio</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Vacca</surname><given-names>Carmine</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Iannitti</surname><given-names>Rossana</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tissi</surname><given-names>Luciana</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Volpi</surname><given-names>Claudia</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Belladonna</surname><given-names>Maria L</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Orabona</surname><given-names>Ciriana</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bianchi</surname><given-names>Roberta</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lanz</surname><given-names>Tobias</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Platten</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Fazia</surname><given-names>Maria A Della</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Piobbico</surname><given-names>Danilo</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Zelante</surname><given-names>Teresa</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Funakoshi</surname><given-names>Hiroshi</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Nakamura</surname><given-names>Toshikazu</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Gilot</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Denison</surname><given-names>Michael S</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Guillemin</surname><given-names>Gilles J</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>DuHadaway</surname><given-names>James B</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Prendergast</surname><given-names>George C</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Metz</surname><given-names>Richard</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Geffard</surname><given-names>Michel</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Boon</surname><given-names>Louis</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Pirro</surname><given-names>Matteo</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Iorio</surname><given-names>Alfonso</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Veyret</surname><given-names>Bernard</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Romani</surname><given-names>Luigina</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Grohmann</surname><given-names>Ursula</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Fallarino</surname><given-names>Francesca</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="CR1">18</xref></contrib><contrib contrib-type="author"><name><surname>Puccetti</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="CR1">18</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Experimental Medicine, University of Perugia, Perugia, Italy</aff><aff id="A2"><label>2</label>University of Bordeaux, IMS Laboratory, Pessac, France</aff><aff id="A3"><label>3</label>Department of Clinical and Experimental Medicine, University of Perugia, Italy</aff><aff id="A4"><label>4</label>Center for Genome Research, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy</aff><aff id="A5"><label>5</label>Department of Chemistry and Technology of Drugs, University of Perugia, Italy</aff><aff id="A6"><label>6</label>Experimental Neuroimmunology Unit, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A7"><label>7</label>Department of Neurooncology, University Hospital, Heidelberg, Germany</aff><aff id="A8"><label>8</label>Center for Advanced Research and Education, Asahikawa Medical University, Asahikawa, Japan</aff><aff id="A9"><label>9</label>Kringle Pharma Joint Research Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University, Osaka, Japan</aff><aff id="A10"><label>10</label>4CNRS UMR 6290, Université de Rennes, Rennes, France</aff><aff id="A11"><label>11</label>Department of Environmental Toxicology, University of California, Davis, CA</aff><aff id="A12"><label>12</label>Australian School of Advanced Medicine (ASAM), Macquarie University, NSW, 2109, Australia</aff><aff id="A13"><label>13</label>Lankenau Institute for Medical Research, Wynnewood, PA</aff><aff id="A14"><label>14</label>New Link Genetics Corporation, Ames, IA</aff><aff id="A15"><label>15</label>Bioceros, Utrecht, The Netherlands</aff><aff id="A16"><label>16</label>Department of Clinical and Experimental Medicine, University of Perugia, Italy</aff><aff id="A17"><label>17</label>Clinical Epidemiology and Biostatistics and Medicine, McMaster University, Canada</aff><author-notes><corresp id="CR1"><label>18</label>These authors share senior authorship on this paper; to whom correspondence should be addressed (P.P., <email>plopcc@tin.it</email>; F.F., <email>fllfnc@tin.it</email>)</corresp><fn id="FN1"><label>17</label><p id="P1">These authors contributed equally to this work</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>4</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>10</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>10</day><month>2</month><year>2015</year></pub-date><volume>511</volume><issue>7508</issue><fpage>184</fpage><lpage>190</lpage><pmc-comment>elocation-id from pubmed: 10.1038/nature13323</pmc-comment>
<abstract><sec id="S1"><title>Summary</title><p id="P2">Disease tolerance is the ability of the host to reduce the impact of infection on host fitness. Analysis of disease tolerance pathways could provide new approaches for treating infections and other inflammatory diseases. Typically, an initial exposure to bacterial lipopolysaccharide (LPS) induces a state of refractoriness to further LPS challenge (“endotoxin tolerance”). We found that a first exposure to LPS activated the ligand-operated transcription factor aryl hydrocarbon receptor (AhR) and the hepatic enzyme tryptophan 2,3-dioxygenase 2, which provided an activating ligand to the former, to downregulate early inflammatory gene expression. However, on LPS rechallenge, AhR engaged in long-term regulation of systemic inflammation only in the presence of indoleamine 2,3-dioxygenase 1 (IDO1). AhR complex-associated Src kinase activity promoted IDO1 phosphorylation and signaling ability. The resulting endotoxin-tolerant state was found to protect mice against immunopathology in gram-negative and gram-positive infections, pointing to a role for AhR in contributing to host fitness.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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