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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Seventy-five genetic loci influencing the human red blood cell</title><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation></author><author><name sortKey="Leach, Irene Mateo" sort="Leach, Irene Mateo" uniqKey="Leach I" first="Irene Mateo" last="Leach">Irene Mateo Leach</name><affiliation><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rendon, Augusto" sort="Rendon, Augusto" uniqKey="Rendon A" first="Augusto" last="Rendon">Augusto Rendon</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A7">MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sehmi, Joban" sort="Sehmi, Joban" uniqKey="Sehmi J" first="Joban" last="Sehmi">Joban Sehmi</name><affiliation><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff></affiliation></author><author><name sortKey="Paul, Dirk S" sort="Paul, Dirk S" uniqKey="Paul D" first="Dirk S." last="Paul">Dirk S. Paul</name><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Elling, Ulrich" sort="Elling, Ulrich" uniqKey="Elling U" first="Ulrich" last="Elling">Ulrich Elling</name><affiliation><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Allayee, Hooman" sort="Allayee, Hooman" uniqKey="Allayee H" first="Hooman" last="Allayee">Hooman Allayee</name><affiliation><nlm:aff id="A12">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Xinzhong" sort="Li, Xinzhong" uniqKey="Li X" first="Xinzhong" last="Li">Xinzhong Li</name><affiliation><nlm:aff id="A13">Institute of Clinical Sciences, Imperial College London, London W12 0NN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A14">NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London SW3 6NP, UK</nlm:aff></affiliation></author><author><name sortKey="Radhakrishnan, Aparna" sort="Radhakrishnan, Aparna" uniqKey="Radhakrishnan A" first="Aparna" last="Radhakrishnan">Aparna Radhakrishnan</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Tan, Sian Tsung" sort="Tan, Sian Tsung" uniqKey="Tan S" first="Sian-Tsung" last="Tan">Sian-Tsung Tan</name><affiliation><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff></affiliation></author><author><name sortKey="Voss, Katrin" sort="Voss, Katrin" uniqKey="Voss K" first="Katrin" last="Voss">Katrin Voss</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Weichenberger, Christian X" sort="Weichenberger, Christian X" uniqKey="Weichenberger C" first="Christian X." last="Weichenberger">Christian X. Weichenberger</name><affiliation><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Albers, Cornelis A" sort="Albers, Cornelis A" uniqKey="Albers C" first="Cornelis A." last="Albers">Cornelis A. Albers</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Al Hussani, Abtehale" sort="Al Hussani, Abtehale" uniqKey="Al Hussani A" first="Abtehale" last="Al-Hussani">Abtehale Al-Hussani</name><affiliation><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W." last="Asselbergs">Folkert W. Asselbergs</name><affiliation><nlm:aff id="A16">Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name><affiliation><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Danjou, Fabrice" sort="Danjou, Fabrice" uniqKey="Danjou F" first="Fabrice" last="Danjou">Fabrice Danjou</name><affiliation><nlm:aff id="A20">Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Dina, Christian" sort="Dina, Christian" uniqKey="Dina C" first="Christian" last="Dina">Christian Dina</name><affiliation><nlm:aff id="A21">Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche (UMR) 1087, BP 70721 44007 Nantes cedex, 1 Nantes, France</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Centre National de la Recherche Scientifique (CNRS) UMR 6291, BP 70721 44007 Nantes cedex 1, Nantes, France</nlm:aff></affiliation><affiliation><nlm:aff id="A23">School of Medecine, Nantes University, 44000 Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="A24">Estonian Genome Center of University of Tartu, 51010 Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation><nlm:aff id="A26">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation><nlm:aff id="A2">Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gogele, Martin" sort="Gogele, Martin" uniqKey="Gogele M" first="Martin" last="Gögele">Martin Gögele</name><affiliation><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Hartiala, Jaana" sort="Hartiala, Jaana" uniqKey="Hartiala J" first="Jaana" last="Hartiala">Jaana Hartiala</name><affiliation><nlm:aff id="A12">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Hersch, Micha" sort="Hersch, Micha" uniqKey="Hersch M" first="Micha" last="Hersch">Micha Hersch</name><affiliation><nlm:aff id="A27">Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Holm, Hilma" sort="Holm, Hilma" uniqKey="Holm H" first="Hilma" last="Holm">Hilma Holm</name><affiliation><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name><affiliation><nlm:aff id="A31">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A32">LURIC Study nonprofit LLC, D-79098 Freiburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Lagou, Vasiliki" sort="Lagou, Vasiliki" uniqKey="Lagou V" first="Vasiliki" last="Lagou">Vasiliki Lagou</name><affiliation><nlm:aff id="A33">Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="A35">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><affiliation><nlm:aff id="A36">Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation><nlm:aff id="A38">Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital, FIN-33521 Tampere, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Department of Clinical Chemistry, University of Tampere School of Medicine, FIN-33521 Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><affiliation><nlm:aff id="A40">Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name><affiliation><nlm:aff id="A41">Institute of Population Genetics, National Research Council of Italy, 07100 Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M." last="Nolte">Ilja M. Nolte</name><affiliation><nlm:aff id="A42">Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F." last="O Eilly">Paul F. O Eilly</name><affiliation><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name><affiliation><nlm:aff id="A43">Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation><nlm:aff id="A44">University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><affiliation><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Porcu, Eleonora" sort="Porcu, Eleonora" uniqKey="Porcu E" first="Eleonora" last="Porcu">Eleonora Porcu</name><affiliation><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name><affiliation><nlm:aff id="A41">Institute of Population Genetics, National Research Council of Italy, 07100 Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A33">Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Ried, Janina S" sort="Ried, Janina S" uniqKey="Ried J" first="Janina S." last="Ried">Janina S. Ried</name><affiliation><nlm:aff id="A47">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Tang, Clara S" sort="Tang, Clara S" uniqKey="Tang C" first="Clara S." last="Tang">Clara S. Tang</name><affiliation><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="A49">Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Traglia, Michela" sort="Traglia, Michela" uniqKey="Traglia M" first="Michela" last="Traglia">Michela Traglia</name><affiliation><nlm:aff id="A50">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name><affiliation><nlm:aff id="A51">Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”- Trieste, 34137 Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Westra, Harm Jan" sort="Westra, Harm Jan" uniqKey="Westra H" first="Harm-Jan" last="Westra">Harm-Jan Westra</name><affiliation><nlm:aff id="A2">Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation><nlm:aff id="A52">University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A35">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Anni, Franco" sort="Anni, Franco" uniqKey="Anni F" first="Franco" last="Anni">Franco Anni</name><affiliation><nlm:aff id="A20">Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Abdellaoui, Abdel" sort="Abdellaoui, Abdel" uniqKey="Abdellaoui A" first="Abdel" last="Abdellaoui">Abdel Abdellaoui</name><affiliation><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Attwood, Antony" sort="Attwood, Antony" uniqKey="Attwood A" first="Antony" last="Attwood">Antony Attwood</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation><nlm:aff id="A53">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Villejuif F-94807, France</nlm:aff></affiliation><affiliation><nlm:aff id="A54">University Paris Sud 11, UMRS 1018, Villejuif F-94807, France</nlm:aff></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation><nlm:aff id="A55">Geriatric Unit, Azienda Sanitaria Firenze, 50125 Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Bastardot, Francois" sort="Bastardot, Francois" uniqKey="Bastardot F" first="François" last="Bastardot">François Bastardot</name><affiliation><nlm:aff id="A56">Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Department of Internal Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Benyamin, Beben" sort="Benyamin, Beben" uniqKey="Benyamin B" first="Beben" last="Benyamin">Beben Benyamin</name><affiliation><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia</nlm:aff></affiliation></author><author><name sortKey="Boehm, Bernhard O" sort="Boehm, Bernhard O" uniqKey="Boehm B" first="Bernhard O." last="Boehm">Bernhard O. Boehm</name><affiliation><nlm:aff id="A59">Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, Ulm D-89075, Germany</nlm:aff></affiliation></author><author><name sortKey="Cookson, William O" sort="Cookson, William O" uniqKey="Cookson W" first="William O." last="Cookson">William O. Cookson</name><affiliation><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff></affiliation></author><author><name sortKey="Das, Debashish" sort="Das, Debashish" uniqKey="Das D" first="Debashish" last="Das">Debashish Das</name><affiliation><nlm:aff id="A60">The Hatter Cardiovascular Institute, University College London, London WC1E 6HX, UK</nlm:aff></affiliation></author><author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><affiliation><nlm:aff id="A17">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation></author><author><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A." last="De Boer">Rudolf A. De Boer</name><affiliation><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="De Moor, Marleen H" sort="De Moor, Marleen H" uniqKey="De Moor M" first="Marleen H." last="De Moor">Marleen H. De Moor</name><affiliation><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Dimitriou, Maria" sort="Dimitriou, Maria" uniqKey="Dimitriou M" first="Maria" last="Dimitriou">Maria Dimitriou</name><affiliation><nlm:aff id="A63">Nutrition and Dietetics, Harokopio University, Kallithea 17671, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Domingues, Francisco S" sort="Domingues, Francisco S" uniqKey="Domingues F" first="Francisco S." last="Domingues">Francisco S. Domingues</name><affiliation><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation><nlm:aff id="A64">Institute of Epidemiology I and Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Engstrom, Gunnar" sort="Engstrom, Gunnar" uniqKey="Engstrom G" first="Gunnar" last="Engström">Gunnar Engström</name><affiliation><nlm:aff id="A40">Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Eyjolfsson, Gudmundur Ingi" sort="Eyjolfsson, Gudmundur Ingi" uniqKey="Eyjolfsson G" first="Gudmundur Ingi" last="Eyjolfsson">Gudmundur Ingi Eyjolfsson</name><affiliation><nlm:aff id="A65">The Laboratory in Mjodd, 108 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="A66">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21250, USA</nlm:aff></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation><nlm:aff id="A24">Estonian Genome Center of University of Tartu, 51010 Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Galanello, Renzo" sort="Galanello, Renzo" uniqKey="Galanello R" first="Renzo" last="Galanello">Renzo Galanello</name><affiliation><nlm:aff id="A20">Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Garner, Stephen F" sort="Garner, Stephen F" uniqKey="Garner S" first="Stephen F." last="Garner">Stephen F. Garner</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Genser, Bernd" sort="Genser, Bernd" uniqKey="Genser B" first="Bernd" last="Genser">Bernd Genser</name><affiliation><nlm:aff id="A31">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Gibson, Quince D" sort="Gibson, Quince D" uniqKey="Gibson Q" first="Quince D." last="Gibson">Quince D. Gibson</name><affiliation><nlm:aff id="A44">University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Instituto de Saúde Coletiva, Federal University of Bahia, Salvador, Bahia 40110-040, Brazil</nlm:aff></affiliation></author><author><name sortKey="Girotto, Giorgia" sort="Girotto, Giorgia" uniqKey="Girotto G" first="Giorgia" last="Girotto">Giorgia Girotto</name><affiliation><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Gudbjartsson, Daniel Fannar" sort="Gudbjartsson, Daniel Fannar" uniqKey="Gudbjartsson D" first="Daniel Fannar" last="Gudbjartsson">Daniel Fannar Gudbjartsson</name><affiliation><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Harris, Sarah E" sort="Harris, Sarah E" uniqKey="Harris S" first="Sarah E." last="Harris">Sarah E. Harris</name><affiliation><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Medical Genetics Section, The University of Edinburgh, Edinburgh EH4 2XU, UK</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A69">Institute of Clinical Sciences, Obstetrics and Gynecology, University of Oulu FIN-90220 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Hastie, Claire E" sort="Hastie, Claire E" uniqKey="Hastie C" first="Claire E." last="Hastie">Claire E. Hastie</name><affiliation><nlm:aff id="A43">Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Hedblad, Bo" sort="Hedblad, Bo" uniqKey="Hedblad B" first="Bo" last="Hedblad">Bo Hedblad</name><affiliation><nlm:aff id="A40">Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:aff id="A70">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Hannover Unified Biobank, Hannover Medical School, D-30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Jolley, Jennifer" sort="Jolley, Jennifer" uniqKey="Jolley J" first="Jennifer" last="Jolley">Jennifer Jolley</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A72">Department of Clinical Physiology, Tampere University Hospital, FIN-33521 Tampere, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Department of Clinical Physiology, University of Tampere School of Medicine, FIN-33521 Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Kema, Ido P" sort="Kema, Ido P" uniqKey="Kema I" first="Ido P." last="Kema">Ido P. Kema</name><affiliation><nlm:aff id="A74">Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P." last="Kemp">John P. Kemp</name><affiliation><nlm:aff id="A26">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation><nlm:aff id="A75">Department of Epidemiology, Department of Biostatistics, Harvard School of Public Health, Cambridge, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Lloyd Jones, Heather" sort="Lloyd Jones, Heather" uniqKey="Lloyd Jones H" first="Heather" last="Lloyd-Jones">Heather Lloyd-Jones</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><affiliation><nlm:aff id="A35">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Meacham, Stuart" sort="Meacham, Stuart" uniqKey="Meacham S" first="Stuart" last="Meacham">Stuart Meacham</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name><affiliation><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><affiliation><nlm:aff id="A76">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Memari, Yasin" sort="Memari, Yasin" uniqKey="Memari Y" first="Yasin" last="Memari">Yasin Memari</name><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Mihailov, Evelin" sort="Mihailov, Evelin" uniqKey="Mihailov E" first="Evelin" last="Mihailov">Evelin Mihailov</name><affiliation><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Miller, Kathy" sort="Miller, Kathy" uniqKey="Miller K" first="Kathy" last="Miller">Kathy Miller</name><affiliation><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation></author><author><name sortKey="Moffatt, Miriam F" sort="Moffatt, Miriam F" uniqKey="Moffatt M" first="Miriam F." last="Moffatt">Miriam F. Moffatt</name><affiliation><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation><nlm:aff id="A78">Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Novatchkova, Maria" sort="Novatchkova, Maria" uniqKey="Novatchkova M" first="Maria" last="Novatchkova">Maria Novatchkova</name><affiliation><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Nutile, Teresa" sort="Nutile, Teresa" uniqKey="Nutile T" first="Teresa" last="Nutile">Teresa Nutile</name><affiliation><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Olafsson, Isleifur" sort="Olafsson, Isleifur" uniqKey="Olafsson I" first="Isleifur" last="Olafsson">Isleifur Olafsson</name><affiliation><nlm:aff id="A79">Department of Clinical Biochemistry, Landspitali University Hospital, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Onundarson, Pall T" sort="Onundarson, Pall T" uniqKey="Onundarson P" first="Pall T." last="Onundarson">Pall T. Onundarson</name><affiliation><nlm:aff id="A80">Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Laboratory of Hematology and Coagulation Disorder Center, Landspitali University Hospital, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Parracciani, Debora" sort="Parracciani, Debora" uniqKey="Parracciani D" first="Debora" last="Parracciani">Debora Parracciani</name><affiliation><nlm:aff id="A82">Genetic Park of Ogliastra, Perdasdefogu, Sardinia, Italy</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><affiliation><nlm:aff id="A83">Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A84">Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Department of Psychiatry, Leiden University Medical Centre, 2333 Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Perseu, Lucia" sort="Perseu, Lucia" uniqKey="Perseu L" first="Lucia" last="Perseu">Lucia Perseu</name><affiliation><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Piga, Antonio" sort="Piga, Antonio" uniqKey="Piga A" first="Antonio" last="Piga">Antonio Piga</name><affiliation><nlm:aff id="A86">Division of Pediatrics and Thalassemia Centre, Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, Turin, Italy</nlm:aff></affiliation></author><author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><affiliation><nlm:aff id="A50">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A87">Institute of Health Sciences, University of Oulu, FIN-90220 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A88">National Institute of Health and Welfare, Aapistie 1, P.O. Box 310, FIN-90101 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Puc, Ursula" sort="Puc, Ursula" uniqKey="Puc U" first="Ursula" last="Puc">Ursula Puc</name><affiliation><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation><nlm:aff id="A89">Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FIN-20521 Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FIN-20521 Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name><affiliation><nlm:aff id="A91">The School of Social and Community Medicine, University of Bristol, Bristol BS82PS, UK</nlm:aff></affiliation></author><author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><affiliation><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name><affiliation><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name><affiliation><nlm:aff id="A92">Institute of Diagnostics, University of Oulu, FIN-90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Saint Pierre, Aude" sort="Saint Pierre, Aude" uniqKey="Saint Pierre A" first="Aude" last="Saint-Pierre">Aude Saint-Pierre</name><affiliation><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation><nlm:aff id="A50">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Salumets, Andres" sort="Salumets, Andres" uniqKey="Salumets A" first="Andres" last="Salumets">Andres Salumets</name><affiliation><nlm:aff id="A93">Competence Centre on Reproductive Medicine and Biology, 50410 Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A94">Institute of General and Molecular Pathology, University of Tartu, 51014 Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Sambrook, Jennifer" sort="Sambrook, Jennifer" uniqKey="Sambrook J" first="Jennifer" last="Sambrook">Jennifer Sambrook</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Schepers, Hein" sort="Schepers, Hein" uniqKey="Schepers H" first="Hein" last="Schepers">Hein Schepers</name><affiliation><nlm:aff id="A95">Department of Experimental Hematology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Department of Stem Cell Biology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Carsten Oliver" sort="Schmidt, Carsten Oliver" uniqKey="Schmidt C" first="Carsten Oliver" last="Schmidt">Carsten Oliver Schmidt</name><affiliation><nlm:aff id="A97">Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Sillje, Herman H W" sort="Sillje, Herman H W" uniqKey="Sillje H" first="Herman H. W." last="Silljé">Herman H. W. Silljé</name><affiliation><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sladek, Rob" sort="Sladek, Rob" uniqKey="Sladek R" first="Rob" last="Sladek">Rob Sladek</name><affiliation><nlm:aff id="A98">Departments of Human Genetics and Medicine, Faculty of Medicine, McGill University, Montreal, Quebec H3A 1B1, Canada</nlm:aff></affiliation></author><author><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H." last="Smit">Johannes H. Smit</name><affiliation><nlm:aff id="A83">Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A99">Geriatric Medicine Unit, The University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK</nlm:aff></affiliation></author><author><name sortKey="Stephens, Jonathan" sort="Stephens, Jonathan" uniqKey="Stephens J" first="Jonathan" last="Stephens">Jonathan Stephens</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><affiliation><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:aff id="A66">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21250, USA</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A100">Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Tragante, Vinicius" sort="Tragante, Vinicius" uniqKey="Tragante V" first="Vinicius" last="Tragante">Vinicius Tragante</name><affiliation><nlm:aff id="A16">Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Gilst, Wiek H" sort="Van Gilst, Wiek H" uniqKey="Van Gilst W" first="Wiek H." last="Van Gilst">Wiek H. Van Gilst</name><affiliation><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Pelt, L Joost" sort="Van Pelt, L Joost" uniqKey="Van Pelt L" first="L. Joost" last="Van Pelt">L. Joost Van Pelt</name><affiliation><nlm:aff id="A74">Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Veldhuisen, Dirk J" sort="Van Veldhuisen, Dirk J" uniqKey="Van Veldhuisen D" first="Dirk J." last="Van Veldhuisen">Dirk J. Van Veldhuisen</name><affiliation><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:aff id="A49">Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><affiliation><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Winkelmann, Bernhard R" sort="Winkelmann, Bernhard R" uniqKey="Winkelmann B" first="Bernhard R." last="Winkelmann">Bernhard R. Winkelmann</name><affiliation><nlm:aff id="A101">Clin Phenomics Study Center, D-60594 Frankfurt, Germany</nlm:aff></affiliation></author><author><name sortKey="Wirnsberger, Gerald" sort="Wirnsberger, Gerald" uniqKey="Wirnsberger G" first="Gerald" last="Wirnsberger">Gerald Wirnsberger</name><affiliation><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Algra, Ale" sort="Algra, Ale" uniqKey="Algra A" first="Ale" last="Algra">Ale Algra</name><affiliation><nlm:aff id="A17">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name><affiliation><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A103">Dipartimento di Scienze Biomediche, Università di Sassari, 07100 Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="D Damo, Adamo Pio" sort="D Damo, Adamo Pio" uniqKey="D Damo A" first="Adamo Pio" last="D Damo">Adamo Pio D Damo</name><affiliation><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name><affiliation><nlm:aff id="A104">Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation><nlm:aff id="A36">Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation></author><author><name sortKey="Dominiczak, Anna F" sort="Dominiczak, Anna F" uniqKey="Dominiczak A" first="Anna F." last="Dominiczak">Anna F. Dominiczak</name><affiliation><nlm:aff id="A43">Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A105">MRC-HPA Centre for Environment and Health, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Fortina, Paolo" sort="Fortina, Paolo" uniqKey="Fortina P" first="Paolo" last="Fortina">Paolo Fortina</name><affiliation><nlm:aff id="A106">Department of Cancer Biology, Thomas Jefferson University Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A107">Dipartimento di Medicina Molecolare, Università La Sapienza, 00161 Roma, Italy</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A108">Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59100, France</nlm:aff></affiliation><affiliation><nlm:aff id="A109">Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><affiliation><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Greinacher, Andreas" sort="Greinacher, Andreas" uniqKey="Greinacher A" first="Andreas" last="Greinacher">Andreas Greinacher</name><affiliation><nlm:aff id="A110">Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, D-17487 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Hazen, Stanley L" sort="Hazen, Stanley L" uniqKey="Hazen S" first="Stanley L." last="Hazen">Stanley L. Hazen</name><affiliation><nlm:aff id="A111">Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Institute of Health Sciences, University of Oulu, FIN-90220 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A105">MRC-HPA Centre for Environment and Health, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A112">Department of Lifecourse snd Service, National Institute for Health and Welfare, FIN-90101 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A113">Biocenter Oulu, University of Oulu, FIN-90220 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay Tee" last="Khaw">Kay Tee Khaw</name><affiliation><nlm:aff id="A114">Clinical Gerontology Unit, Box 251, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="A38">Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital, FIN-33521 Tampere, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Department of Clinical Chemistry, University of Tampere School of Medicine, FIN-33521 Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Maerz, Winfried" sort="Maerz, Winfried" uniqKey="Maerz W" first="Winfried" last="Maerz">Winfried Maerz</name><affiliation><nlm:aff id="A31">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A115">Synlab Academy, D-68165 Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A24">Estonian Genome Center of University of Tartu, 51010 Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation><nlm:aff id="A44">University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Moore, Carmel" sort="Moore, Carmel" uniqKey="Moore C" first="Carmel" last="Moore">Carmel Moore</name><affiliation><nlm:aff id="A104">Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation><nlm:aff id="A116">Department of Internal Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><affiliation><nlm:aff id="A41">Institute of Population Genetics, National Research Council of Italy, 07100 Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A117">Department of Neurology, General Central Hospital, 39100 Bolzano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A118">Department of Neurology, University of Lübeck, D-23538 Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Ramirez Solis, Ramiro" sort="Ramirez Solis, Ramiro" uniqKey="Ramirez Solis R" first="Ramiro" last="Ramirez-Solis">Ramiro Ramirez-Solis</name><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Schadt, Eric" sort="Schadt, Eric" uniqKey="Schadt E" first="Eric" last="Schadt">Eric Schadt</name><affiliation><nlm:aff id="A119">Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York 10029-6574, USA</nlm:aff></affiliation></author><author><name sortKey="Scott, James" sort="Scott, James" uniqKey="Scott J" first="James" last="Scott">James Scott</name><affiliation><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A44">University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A120">Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation><nlm:aff id="A26">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Smith, J Gustav" sort="Smith, J Gustav" uniqKey="Smith J" first="J. Gustav" last="Smith">J. Gustav Smith</name><affiliation><nlm:aff id="A40">Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A121">Department of Cardiology, Lund University, 22185 Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:aff id="A42">Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><affiliation><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation><nlm:aff id="A122">Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A100">Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="A123">Department of Medicine, University of Leipzig, Liebigstr. 18, D-04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A124">University of Leipzig, IFB Adiposity Diseases, D-04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Wilson Tang, W H" sort="Wilson Tang, W H" uniqKey="Wilson Tang W" first="W. H." last="Wilson Tang">W. H. Wilson Tang</name><affiliation><nlm:aff id="A111">Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA</nlm:aff></affiliation></author><author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><affiliation><nlm:aff id="A50">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A125">Insitute of Molecular Genetics, CNR, 27100 Pavia, Italy</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="A123">Department of Medicine, University of Leipzig, Liebigstr. 18, D-04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A124">University of Leipzig, IFB Adiposity Diseases, D-04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name><affiliation><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A52">University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A56">Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Department of Internal Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A35">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce H R" sort="Wolffenbuttel, Bruce H R" uniqKey="Wolffenbuttel B" first="Bruce H. R." last="Wolffenbuttel">Bruce H. R. Wolffenbuttel</name><affiliation><nlm:aff id="A126">Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S." last="Beckmann">Jacques S. Beckmann</name><affiliation><nlm:aff id="A27">Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A127">Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V." last="Dedoussis">George V. Dedoussis</name><affiliation><nlm:aff id="A63">Nutrition and Dietetics, Harokopio University, Kallithea 17671, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Ferreira, Manuel A" sort="Ferreira, Manuel A" uniqKey="Ferreira M" first="Manuel A." last="Ferreira">Manuel A. Ferreira</name><affiliation><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Uda, Manuela" sort="Uda, Manuela" uniqKey="Uda M" first="Manuela" last="Uda">Manuela Uda</name><affiliation><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Penninger, Josef Martin" sort="Penninger, Josef Martin" uniqKey="Penninger J" first="Josef Martin" last="Penninger">Josef Martin Penninger</name><affiliation><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A47">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><affiliation><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A128">Imperial College Healthcare NHS Trust, London W12 0HS, UK</nlm:aff></affiliation></author><author><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C" last="Chambers">John C. Chambers</name><affiliation><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A14">NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London SW3 6NP, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A128">Imperial College Healthcare NHS Trust, London W12 0HS, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23222517</idno><idno type="pmc">3623669</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623669</idno><idno type="RBID">PMC:3623669</idno><idno type="doi">10.1038/nature11677</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001D33</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D33</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Seventy-five genetic loci influencing the human red blood cell</title><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation></author><author><name sortKey="Leach, Irene Mateo" sort="Leach, Irene Mateo" uniqKey="Leach I" first="Irene Mateo" last="Leach">Irene Mateo Leach</name><affiliation><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rendon, Augusto" sort="Rendon, Augusto" uniqKey="Rendon A" first="Augusto" last="Rendon">Augusto Rendon</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A7">MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sehmi, Joban" sort="Sehmi, Joban" uniqKey="Sehmi J" first="Joban" last="Sehmi">Joban Sehmi</name><affiliation><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff></affiliation></author><author><name sortKey="Paul, Dirk S" sort="Paul, Dirk S" uniqKey="Paul D" first="Dirk S." last="Paul">Dirk S. Paul</name><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Elling, Ulrich" sort="Elling, Ulrich" uniqKey="Elling U" first="Ulrich" last="Elling">Ulrich Elling</name><affiliation><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Allayee, Hooman" sort="Allayee, Hooman" uniqKey="Allayee H" first="Hooman" last="Allayee">Hooman Allayee</name><affiliation><nlm:aff id="A12">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Xinzhong" sort="Li, Xinzhong" uniqKey="Li X" first="Xinzhong" last="Li">Xinzhong Li</name><affiliation><nlm:aff id="A13">Institute of Clinical Sciences, Imperial College London, London W12 0NN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A14">NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London SW3 6NP, UK</nlm:aff></affiliation></author><author><name sortKey="Radhakrishnan, Aparna" sort="Radhakrishnan, Aparna" uniqKey="Radhakrishnan A" first="Aparna" last="Radhakrishnan">Aparna Radhakrishnan</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Tan, Sian Tsung" sort="Tan, Sian Tsung" uniqKey="Tan S" first="Sian-Tsung" last="Tan">Sian-Tsung Tan</name><affiliation><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff></affiliation></author><author><name sortKey="Voss, Katrin" sort="Voss, Katrin" uniqKey="Voss K" first="Katrin" last="Voss">Katrin Voss</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Weichenberger, Christian X" sort="Weichenberger, Christian X" uniqKey="Weichenberger C" first="Christian X." last="Weichenberger">Christian X. Weichenberger</name><affiliation><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Albers, Cornelis A" sort="Albers, Cornelis A" uniqKey="Albers C" first="Cornelis A." last="Albers">Cornelis A. Albers</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Al Hussani, Abtehale" sort="Al Hussani, Abtehale" uniqKey="Al Hussani A" first="Abtehale" last="Al-Hussani">Abtehale Al-Hussani</name><affiliation><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W." last="Asselbergs">Folkert W. Asselbergs</name><affiliation><nlm:aff id="A16">Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name><affiliation><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Danjou, Fabrice" sort="Danjou, Fabrice" uniqKey="Danjou F" first="Fabrice" last="Danjou">Fabrice Danjou</name><affiliation><nlm:aff id="A20">Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Dina, Christian" sort="Dina, Christian" uniqKey="Dina C" first="Christian" last="Dina">Christian Dina</name><affiliation><nlm:aff id="A21">Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche (UMR) 1087, BP 70721 44007 Nantes cedex, 1 Nantes, France</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Centre National de la Recherche Scientifique (CNRS) UMR 6291, BP 70721 44007 Nantes cedex 1, Nantes, France</nlm:aff></affiliation><affiliation><nlm:aff id="A23">School of Medecine, Nantes University, 44000 Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="A24">Estonian Genome Center of University of Tartu, 51010 Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation><nlm:aff id="A26">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation><nlm:aff id="A2">Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Gogele, Martin" sort="Gogele, Martin" uniqKey="Gogele M" first="Martin" last="Gögele">Martin Gögele</name><affiliation><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Hartiala, Jaana" sort="Hartiala, Jaana" uniqKey="Hartiala J" first="Jaana" last="Hartiala">Jaana Hartiala</name><affiliation><nlm:aff id="A12">Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Hersch, Micha" sort="Hersch, Micha" uniqKey="Hersch M" first="Micha" last="Hersch">Micha Hersch</name><affiliation><nlm:aff id="A27">Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Holm, Hilma" sort="Holm, Hilma" uniqKey="Holm H" first="Hilma" last="Holm">Hilma Holm</name><affiliation><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name><affiliation><nlm:aff id="A31">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A32">LURIC Study nonprofit LLC, D-79098 Freiburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Lagou, Vasiliki" sort="Lagou, Vasiliki" uniqKey="Lagou V" first="Vasiliki" last="Lagou">Vasiliki Lagou</name><affiliation><nlm:aff id="A33">Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="A35">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><affiliation><nlm:aff id="A36">Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation><nlm:aff id="A38">Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital, FIN-33521 Tampere, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Department of Clinical Chemistry, University of Tampere School of Medicine, FIN-33521 Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><affiliation><nlm:aff id="A40">Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name><affiliation><nlm:aff id="A41">Institute of Population Genetics, National Research Council of Italy, 07100 Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M." last="Nolte">Ilja M. Nolte</name><affiliation><nlm:aff id="A42">Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F." last="O Eilly">Paul F. O Eilly</name><affiliation><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name><affiliation><nlm:aff id="A43">Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation><nlm:aff id="A44">University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><affiliation><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Porcu, Eleonora" sort="Porcu, Eleonora" uniqKey="Porcu E" first="Eleonora" last="Porcu">Eleonora Porcu</name><affiliation><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name><affiliation><nlm:aff id="A41">Institute of Population Genetics, National Research Council of Italy, 07100 Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A33">Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford OX3 7LJ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation></author><author><name sortKey="Ried, Janina S" sort="Ried, Janina S" uniqKey="Ried J" first="Janina S." last="Ried">Janina S. Ried</name><affiliation><nlm:aff id="A47">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Tang, Clara S" sort="Tang, Clara S" uniqKey="Tang C" first="Clara S." last="Tang">Clara S. Tang</name><affiliation><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="A49">Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Traglia, Michela" sort="Traglia, Michela" uniqKey="Traglia M" first="Michela" last="Traglia">Michela Traglia</name><affiliation><nlm:aff id="A50">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name><affiliation><nlm:aff id="A51">Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”- Trieste, 34137 Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Westra, Harm Jan" sort="Westra, Harm Jan" uniqKey="Westra H" first="Harm-Jan" last="Westra">Harm-Jan Westra</name><affiliation><nlm:aff id="A2">Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation><nlm:aff id="A52">University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A35">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Anni, Franco" sort="Anni, Franco" uniqKey="Anni F" first="Franco" last="Anni">Franco Anni</name><affiliation><nlm:aff id="A20">Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Abdellaoui, Abdel" sort="Abdellaoui, Abdel" uniqKey="Abdellaoui A" first="Abdel" last="Abdellaoui">Abdel Abdellaoui</name><affiliation><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Attwood, Antony" sort="Attwood, Antony" uniqKey="Attwood A" first="Antony" last="Attwood">Antony Attwood</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation><nlm:aff id="A53">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Villejuif F-94807, France</nlm:aff></affiliation><affiliation><nlm:aff id="A54">University Paris Sud 11, UMRS 1018, Villejuif F-94807, France</nlm:aff></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation><nlm:aff id="A55">Geriatric Unit, Azienda Sanitaria Firenze, 50125 Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Bastardot, Francois" sort="Bastardot, Francois" uniqKey="Bastardot F" first="François" last="Bastardot">François Bastardot</name><affiliation><nlm:aff id="A56">Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Department of Internal Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Benyamin, Beben" sort="Benyamin, Beben" uniqKey="Benyamin B" first="Beben" last="Benyamin">Beben Benyamin</name><affiliation><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia</nlm:aff></affiliation></author><author><name sortKey="Boehm, Bernhard O" sort="Boehm, Bernhard O" uniqKey="Boehm B" first="Bernhard O." last="Boehm">Bernhard O. Boehm</name><affiliation><nlm:aff id="A59">Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, Ulm D-89075, Germany</nlm:aff></affiliation></author><author><name sortKey="Cookson, William O" sort="Cookson, William O" uniqKey="Cookson W" first="William O." last="Cookson">William O. Cookson</name><affiliation><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff></affiliation></author><author><name sortKey="Das, Debashish" sort="Das, Debashish" uniqKey="Das D" first="Debashish" last="Das">Debashish Das</name><affiliation><nlm:aff id="A60">The Hatter Cardiovascular Institute, University College London, London WC1E 6HX, UK</nlm:aff></affiliation></author><author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><affiliation><nlm:aff id="A17">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff></affiliation></author><author><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A." last="De Boer">Rudolf A. De Boer</name><affiliation><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="De Moor, Marleen H" sort="De Moor, Marleen H" uniqKey="De Moor M" first="Marleen H." last="De Moor">Marleen H. De Moor</name><affiliation><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Dimitriou, Maria" sort="Dimitriou, Maria" uniqKey="Dimitriou M" first="Maria" last="Dimitriou">Maria Dimitriou</name><affiliation><nlm:aff id="A63">Nutrition and Dietetics, Harokopio University, Kallithea 17671, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Domingues, Francisco S" sort="Domingues, Francisco S" uniqKey="Domingues F" first="Francisco S." last="Domingues">Francisco S. Domingues</name><affiliation><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation><nlm:aff id="A64">Institute of Epidemiology I and Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Engstrom, Gunnar" sort="Engstrom, Gunnar" uniqKey="Engstrom G" first="Gunnar" last="Engström">Gunnar Engström</name><affiliation><nlm:aff id="A40">Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Eyjolfsson, Gudmundur Ingi" sort="Eyjolfsson, Gudmundur Ingi" uniqKey="Eyjolfsson G" first="Gudmundur Ingi" last="Eyjolfsson">Gudmundur Ingi Eyjolfsson</name><affiliation><nlm:aff id="A65">The Laboratory in Mjodd, 108 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="A66">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21250, USA</nlm:aff></affiliation></author><author><name sortKey="Fischer, Krista" sort="Fischer, Krista" uniqKey="Fischer K" first="Krista" last="Fischer">Krista Fischer</name><affiliation><nlm:aff id="A24">Estonian Genome Center of University of Tartu, 51010 Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Galanello, Renzo" sort="Galanello, Renzo" uniqKey="Galanello R" first="Renzo" last="Galanello">Renzo Galanello</name><affiliation><nlm:aff id="A20">Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Garner, Stephen F" sort="Garner, Stephen F" uniqKey="Garner S" first="Stephen F." last="Garner">Stephen F. Garner</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Genser, Bernd" sort="Genser, Bernd" uniqKey="Genser B" first="Bernd" last="Genser">Bernd Genser</name><affiliation><nlm:aff id="A31">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Gibson, Quince D" sort="Gibson, Quince D" uniqKey="Gibson Q" first="Quince D." last="Gibson">Quince D. Gibson</name><affiliation><nlm:aff id="A44">University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Instituto de Saúde Coletiva, Federal University of Bahia, Salvador, Bahia 40110-040, Brazil</nlm:aff></affiliation></author><author><name sortKey="Girotto, Giorgia" sort="Girotto, Giorgia" uniqKey="Girotto G" first="Giorgia" last="Girotto">Giorgia Girotto</name><affiliation><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Gudbjartsson, Daniel Fannar" sort="Gudbjartsson, Daniel Fannar" uniqKey="Gudbjartsson D" first="Daniel Fannar" last="Gudbjartsson">Daniel Fannar Gudbjartsson</name><affiliation><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Harris, Sarah E" sort="Harris, Sarah E" uniqKey="Harris S" first="Sarah E." last="Harris">Sarah E. Harris</name><affiliation><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Medical Genetics Section, The University of Edinburgh, Edinburgh EH4 2XU, UK</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A69">Institute of Clinical Sciences, Obstetrics and Gynecology, University of Oulu FIN-90220 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Hastie, Claire E" sort="Hastie, Claire E" uniqKey="Hastie C" first="Claire E." last="Hastie">Claire E. Hastie</name><affiliation><nlm:aff id="A43">Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Hedblad, Bo" sort="Hedblad, Bo" uniqKey="Hedblad B" first="Bo" last="Hedblad">Bo Hedblad</name><affiliation><nlm:aff id="A40">Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:aff id="A70">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Hannover Unified Biobank, Hannover Medical School, D-30625 Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Jolley, Jennifer" sort="Jolley, Jennifer" uniqKey="Jolley J" first="Jennifer" last="Jolley">Jennifer Jolley</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:aff id="A72">Department of Clinical Physiology, Tampere University Hospital, FIN-33521 Tampere, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Department of Clinical Physiology, University of Tampere School of Medicine, FIN-33521 Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Kema, Ido P" sort="Kema, Ido P" uniqKey="Kema I" first="Ido P." last="Kema">Ido P. Kema</name><affiliation><nlm:aff id="A74">Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P." last="Kemp">John P. Kemp</name><affiliation><nlm:aff id="A26">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation><nlm:aff id="A75">Department of Epidemiology, Department of Biostatistics, Harvard School of Public Health, Cambridge, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Lloyd Jones, Heather" sort="Lloyd Jones, Heather" uniqKey="Lloyd Jones H" first="Heather" last="Lloyd-Jones">Heather Lloyd-Jones</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><affiliation><nlm:aff id="A35">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Meacham, Stuart" sort="Meacham, Stuart" uniqKey="Meacham S" first="Stuart" last="Meacham">Stuart Meacham</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name><affiliation><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><affiliation><nlm:aff id="A76">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Memari, Yasin" sort="Memari, Yasin" uniqKey="Memari Y" first="Yasin" last="Memari">Yasin Memari</name><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A77">Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Mihailov, Evelin" sort="Mihailov, Evelin" uniqKey="Mihailov E" first="Evelin" last="Mihailov">Evelin Mihailov</name><affiliation><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Miller, Kathy" sort="Miller, Kathy" uniqKey="Miller K" first="Kathy" last="Miller">Kathy Miller</name><affiliation><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation></author><author><name sortKey="Moffatt, Miriam F" sort="Moffatt, Miriam F" uniqKey="Moffatt M" first="Miriam F." last="Moffatt">Miriam F. Moffatt</name><affiliation><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation><nlm:aff id="A78">Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Novatchkova, Maria" sort="Novatchkova, Maria" uniqKey="Novatchkova M" first="Maria" last="Novatchkova">Maria Novatchkova</name><affiliation><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Nutile, Teresa" sort="Nutile, Teresa" uniqKey="Nutile T" first="Teresa" last="Nutile">Teresa Nutile</name><affiliation><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Olafsson, Isleifur" sort="Olafsson, Isleifur" uniqKey="Olafsson I" first="Isleifur" last="Olafsson">Isleifur Olafsson</name><affiliation><nlm:aff id="A79">Department of Clinical Biochemistry, Landspitali University Hospital, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Onundarson, Pall T" sort="Onundarson, Pall T" uniqKey="Onundarson P" first="Pall T." last="Onundarson">Pall T. Onundarson</name><affiliation><nlm:aff id="A80">Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Laboratory of Hematology and Coagulation Disorder Center, Landspitali University Hospital, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Parracciani, Debora" sort="Parracciani, Debora" uniqKey="Parracciani D" first="Debora" last="Parracciani">Debora Parracciani</name><affiliation><nlm:aff id="A82">Genetic Park of Ogliastra, Perdasdefogu, Sardinia, Italy</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><affiliation><nlm:aff id="A83">Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A84">Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Department of Psychiatry, Leiden University Medical Centre, 2333 Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Perseu, Lucia" sort="Perseu, Lucia" uniqKey="Perseu L" first="Lucia" last="Perseu">Lucia Perseu</name><affiliation><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Piga, Antonio" sort="Piga, Antonio" uniqKey="Piga A" first="Antonio" last="Piga">Antonio Piga</name><affiliation><nlm:aff id="A86">Division of Pediatrics and Thalassemia Centre, Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, Turin, Italy</nlm:aff></affiliation></author><author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><affiliation><nlm:aff id="A50">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A87">Institute of Health Sciences, University of Oulu, FIN-90220 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A88">National Institute of Health and Welfare, Aapistie 1, P.O. Box 310, FIN-90101 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Puc, Ursula" sort="Puc, Ursula" uniqKey="Puc U" first="Ursula" last="Puc">Ursula Puc</name><affiliation><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation><nlm:aff id="A89">Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FIN-20521 Turku, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FIN-20521 Turku, Finland</nlm:aff></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name><affiliation><nlm:aff id="A91">The School of Social and Community Medicine, University of Bristol, Bristol BS82PS, UK</nlm:aff></affiliation></author><author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name><affiliation><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name><affiliation><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name><affiliation><nlm:aff id="A92">Institute of Diagnostics, University of Oulu, FIN-90014 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Saint Pierre, Aude" sort="Saint Pierre, Aude" uniqKey="Saint Pierre A" first="Aude" last="Saint-Pierre">Aude Saint-Pierre</name><affiliation><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation><nlm:aff id="A50">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Salumets, Andres" sort="Salumets, Andres" uniqKey="Salumets A" first="Andres" last="Salumets">Andres Salumets</name><affiliation><nlm:aff id="A93">Competence Centre on Reproductive Medicine and Biology, 50410 Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A94">Institute of General and Molecular Pathology, University of Tartu, 51014 Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Sambrook, Jennifer" sort="Sambrook, Jennifer" uniqKey="Sambrook J" first="Jennifer" last="Sambrook">Jennifer Sambrook</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Schepers, Hein" sort="Schepers, Hein" uniqKey="Schepers H" first="Hein" last="Schepers">Hein Schepers</name><affiliation><nlm:aff id="A95">Department of Experimental Hematology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Department of Stem Cell Biology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Carsten Oliver" sort="Schmidt, Carsten Oliver" uniqKey="Schmidt C" first="Carsten Oliver" last="Schmidt">Carsten Oliver Schmidt</name><affiliation><nlm:aff id="A97">Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Sillje, Herman H W" sort="Sillje, Herman H W" uniqKey="Sillje H" first="Herman H. W." last="Silljé">Herman H. W. Silljé</name><affiliation><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sladek, Rob" sort="Sladek, Rob" uniqKey="Sladek R" first="Rob" last="Sladek">Rob Sladek</name><affiliation><nlm:aff id="A98">Departments of Human Genetics and Medicine, Faculty of Medicine, McGill University, Montreal, Quebec H3A 1B1, Canada</nlm:aff></affiliation></author><author><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H." last="Smit">Johannes H. Smit</name><affiliation><nlm:aff id="A83">Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A99">Geriatric Medicine Unit, The University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK</nlm:aff></affiliation></author><author><name sortKey="Stephens, Jonathan" sort="Stephens, Jonathan" uniqKey="Stephens J" first="Jonathan" last="Stephens">Jonathan Stephens</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><affiliation><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:aff id="A66">Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21250, USA</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A100">Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Tragante, Vinicius" sort="Tragante, Vinicius" uniqKey="Tragante V" first="Vinicius" last="Tragante">Vinicius Tragante</name><affiliation><nlm:aff id="A16">Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Gilst, Wiek H" sort="Van Gilst, Wiek H" uniqKey="Van Gilst W" first="Wiek H." last="Van Gilst">Wiek H. Van Gilst</name><affiliation><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Pelt, L Joost" sort="Van Pelt, L Joost" uniqKey="Van Pelt L" first="L. Joost" last="Van Pelt">L. Joost Van Pelt</name><affiliation><nlm:aff id="A74">Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Veldhuisen, Dirk J" sort="Van Veldhuisen, Dirk J" uniqKey="Van Veldhuisen D" first="Dirk J." last="Van Veldhuisen">Dirk J. Van Veldhuisen</name><affiliation><nlm:aff id="A1">Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:aff id="A49">Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B." last="Whitfield">John B. Whitfield</name><affiliation><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Winkelmann, Bernhard R" sort="Winkelmann, Bernhard R" uniqKey="Winkelmann B" first="Bernhard R." last="Winkelmann">Bernhard R. Winkelmann</name><affiliation><nlm:aff id="A101">Clin Phenomics Study Center, D-60594 Frankfurt, Germany</nlm:aff></affiliation></author><author><name sortKey="Wirnsberger, Gerald" sort="Wirnsberger, Gerald" uniqKey="Wirnsberger G" first="Gerald" last="Wirnsberger">Gerald Wirnsberger</name><affiliation><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Algra, Ale" sort="Algra, Ale" uniqKey="Algra A" first="Ale" last="Algra">Ale Algra</name><affiliation><nlm:aff id="A17">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name><affiliation><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A103">Dipartimento di Scienze Biomediche, Università di Sassari, 07100 Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="D Damo, Adamo Pio" sort="D Damo, Adamo Pio" uniqKey="D Damo A" first="Adamo Pio" last="D Damo">Adamo Pio D Damo</name><affiliation><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name><affiliation><nlm:aff id="A104">Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation><nlm:aff id="A36">Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation></author><author><name sortKey="Dominiczak, Anna F" sort="Dominiczak, Anna F" uniqKey="Dominiczak A" first="Anna F." last="Dominiczak">Anna F. Dominiczak</name><affiliation><nlm:aff id="A43">Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A105">MRC-HPA Centre for Environment and Health, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Fortina, Paolo" sort="Fortina, Paolo" uniqKey="Fortina P" first="Paolo" last="Fortina">Paolo Fortina</name><affiliation><nlm:aff id="A106">Department of Cancer Biology, Thomas Jefferson University Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A107">Dipartimento di Medicina Molecolare, Università La Sapienza, 00161 Roma, Italy</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A108">Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59100, France</nlm:aff></affiliation><affiliation><nlm:aff id="A109">Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><affiliation><nlm:aff id="A45">Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Greinacher, Andreas" sort="Greinacher, Andreas" uniqKey="Greinacher A" first="Andreas" last="Greinacher">Andreas Greinacher</name><affiliation><nlm:aff id="A110">Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, D-17487 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Hazen, Stanley L" sort="Hazen, Stanley L" uniqKey="Hazen S" first="Stanley L." last="Hazen">Stanley L. Hazen</name><affiliation><nlm:aff id="A111">Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Institute of Health Sciences, University of Oulu, FIN-90220 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A105">MRC-HPA Centre for Environment and Health, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A112">Department of Lifecourse snd Service, National Institute for Health and Welfare, FIN-90101 Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A113">Biocenter Oulu, University of Oulu, FIN-90220 Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay Tee" last="Khaw">Kay Tee Khaw</name><affiliation><nlm:aff id="A114">Clinical Gerontology Unit, Box 251, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:aff id="A38">Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital, FIN-33521 Tampere, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Department of Clinical Chemistry, University of Tampere School of Medicine, FIN-33521 Tampere, Finland</nlm:aff></affiliation></author><author><name sortKey="Maerz, Winfried" sort="Maerz, Winfried" uniqKey="Maerz W" first="Winfried" last="Maerz">Winfried Maerz</name><affiliation><nlm:aff id="A31">Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A115">Synlab Academy, D-68165 Mannheim, Germany</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A24">Estonian Genome Center of University of Tartu, 51010 Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A25">Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation><nlm:aff id="A44">University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Moore, Carmel" sort="Moore, Carmel" uniqKey="Moore C" first="Carmel" last="Moore">Carmel Moore</name><affiliation><nlm:aff id="A104">Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation><nlm:aff id="A116">Department of Internal Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><affiliation><nlm:aff id="A41">Institute of Population Genetics, National Research Council of Italy, 07100 Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A117">Department of Neurology, General Central Hospital, 39100 Bolzano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A118">Department of Neurology, University of Lübeck, D-23538 Lübeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Ramirez Solis, Ramiro" sort="Ramirez Solis, Ramiro" uniqKey="Ramirez Solis R" first="Ramiro" last="Ramirez-Solis">Ramiro Ramirez-Solis</name><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Schadt, Eric" sort="Schadt, Eric" uniqKey="Schadt E" first="Eric" last="Schadt">Eric Schadt</name><affiliation><nlm:aff id="A119">Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York 10029-6574, USA</nlm:aff></affiliation></author><author><name sortKey="Scott, James" sort="Scott, James" uniqKey="Scott J" first="James" last="Scott">James Scott</name><affiliation><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A44">University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A120">Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation><nlm:aff id="A26">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Smith, J Gustav" sort="Smith, J Gustav" uniqKey="Smith J" first="J. Gustav" last="Smith">J. Gustav Smith</name><affiliation><nlm:aff id="A40">Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A121">Department of Cardiology, Lund University, 22185 Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:aff id="A42">Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><affiliation><nlm:aff id="A19">Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation><nlm:aff id="A122">Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A29">deCODE genetics, 101 Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A100">Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="A123">Department of Medicine, University of Leipzig, Liebigstr. 18, D-04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A124">University of Leipzig, IFB Adiposity Diseases, D-04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Wilson Tang, W H" sort="Wilson Tang, W H" uniqKey="Wilson Tang W" first="W. H." last="Wilson Tang">W. H. Wilson Tang</name><affiliation><nlm:aff id="A111">Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA</nlm:aff></affiliation></author><author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><affiliation><nlm:aff id="A50">Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A125">Insitute of Molecular Genetics, CNR, 27100 Pavia, Italy</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="A123">Department of Medicine, University of Leipzig, Liebigstr. 18, D-04103 Leipzig, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A124">University of Leipzig, IFB Adiposity Diseases, D-04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name><affiliation><nlm:aff id="A37">Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A52">University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A56">Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Department of Internal Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A35">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce H R" sort="Wolffenbuttel, Bruce H R" uniqKey="Wolffenbuttel B" first="Bruce H. R." last="Wolffenbuttel">Bruce H. R. Wolffenbuttel</name><affiliation><nlm:aff id="A126">Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A30">Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Jacques S" sort="Beckmann, Jacques S" uniqKey="Beckmann J" first="Jacques S." last="Beckmann">Jacques S. Beckmann</name><affiliation><nlm:aff id="A27">Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A127">Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V." last="Dedoussis">George V. Dedoussis</name><affiliation><nlm:aff id="A63">Nutrition and Dietetics, Harokopio University, Kallithea 17671, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Ferreira, Manuel A" sort="Ferreira, Manuel A" uniqKey="Ferreira M" first="Manuel A." last="Ferreira">Manuel A. Ferreira</name><affiliation><nlm:aff id="A48">Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Uda, Manuela" sort="Uda, Manuela" uniqKey="Uda M" first="Manuela" last="Uda">Manuela Uda</name><affiliation><nlm:aff id="A46">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A15">Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Penninger, Josef Martin" sort="Penninger, Josef Martin" uniqKey="Penninger J" first="Josef Martin" last="Penninger">Josef Martin Penninger</name><affiliation><nlm:aff id="A11">Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A47">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><affiliation><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9">National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A128">Imperial College Healthcare NHS Trust, London W12 0HS, UK</nlm:aff></affiliation></author><author><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name><affiliation><nlm:aff id="A5">Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A6">NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:aff id="A10">Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C" last="Chambers">John C. Chambers</name><affiliation><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A14">NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London SW3 6NP, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A128">Imperial College Healthcare NHS Trust, London W12 0HS, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Nature</title><idno type="ISSN">0028-0836</idno><idno type="eISSN">1476-4687</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Anaemia is a chief determinant of globalill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at <italic>P</italic> <10<sup>−8</sup>, which together explain 4–9% of the phenotypic variance per trait. Using expression quantitative trait loci and bioinformatic strategies, we identify 121 candidate genes enriched in functions relevant to red blood cell biology. The candidate genes are expressed preferentially in red blood cell precursors, and 43 have haematopoietic phenotypes in <italic>Mus musculus</italic> or <italic>Drosophila melanogaster</italic>. Through open-chromatin and coding-variant analyses we identify potential causal genetic variants at 41 loci. Our findings provide extensive new insights into genetic mechanisms and biological pathways controlling red blood cell formation and function.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0410462</journal-id><journal-id journal-id-type="pubmed-jr-id">6011</journal-id><journal-id journal-id-type="nlm-ta">Nature</journal-id><journal-id journal-id-type="iso-abbrev">Nature</journal-id><journal-title-group><journal-title>Nature</journal-title></journal-title-group><issn pub-type="ppub">0028-0836</issn><issn pub-type="epub">1476-4687</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23222517</article-id><article-id pub-id-type="pmc">3623669</article-id><article-id pub-id-type="doi">10.1038/nature11677</article-id><article-id pub-id-type="manuscript">NIHMS447872</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Seventy-five genetic loci influencing the human red blood cell</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>van der 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contrib-type="author"><name><surname>Sanna</surname><given-names>Serena</given-names></name><xref ref-type="aff" rid="A46">46</xref></contrib><contrib contrib-type="author"><name><surname>Uda</surname><given-names>Manuela</given-names></name><xref ref-type="aff" rid="A46">46</xref></contrib><contrib contrib-type="author"><name><surname>Hicks</surname><given-names>Andrew A.</given-names></name><xref ref-type="aff" rid="A15">15</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Penninger</surname><given-names>Josef Martin</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Gieger</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="A47">47</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Kooner</surname><given-names>Jaspal S.</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A128">128</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Ouwehand</surname><given-names>Willem H.</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A10">10</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Soranzo</surname><given-names>Nicole</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Chambers</surname><given-names>John C</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A14">14</xref><xref ref-type="aff" rid="A128">128</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</aff><aff id="A2"><label>2</label>Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</aff><aff id="A3"><label>3</label>Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</aff><aff id="A4"><label>4</label>Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK</aff><aff id="A5"><label>5</label>Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK</aff><aff id="A6"><label>6</label>NHS Blood and Transplant, Cambridge CB2 0PT, UK</aff><aff id="A7"><label>7</label>MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR, UK</aff><aff id="A8"><label>8</label>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</aff><aff id="A9"><label>9</label>National Heart and Lung Institute, Imperial College London, London W12 0NN, UK</aff><aff id="A10"><label>10</label>Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK</aff><aff id="A11"><label>11</label>Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</aff><aff id="A12"><label>12</label>Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA</aff><aff id="A13"><label>13</label>Institute of Clinical Sciences, Imperial College London, London W12 0NN, UK</aff><aff id="A14"><label>14</label>NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London SW3 6NP, UK</aff><aff id="A15"><label>15</label>Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy</aff><aff id="A16"><label>16</label>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</aff><aff id="A17"><label>17</label>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</aff><aff id="A18"><label>18</label>Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3508 Utrecht, The Netherlands</aff><aff id="A19"><label>19</label>Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, 80131 Naples, Italy</aff><aff id="A20"><label>20</label>Clinica Pediatrica 2a, Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy</aff><aff id="A21"><label>21</label>Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche (UMR) 1087, BP 70721 44007 Nantes cedex, 1 Nantes, France</aff><aff id="A22"><label>22</label>Centre National de la Recherche Scientifique (CNRS) UMR 6291, BP 70721 44007 Nantes cedex 1, Nantes, France</aff><aff id="A23"><label>23</label>School of Medecine, Nantes University, 44000 Nantes, France</aff><aff id="A24"><label>24</label>Estonian Genome Center of University of Tartu, 51010 Tartu, Estonia</aff><aff id="A25"><label>25</label>Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia</aff><aff id="A26"><label>26</label>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK</aff><aff id="A27"><label>27</label>Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland</aff><aff id="A28"><label>28</label>Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland</aff><aff id="A29"><label>29</label>deCODE genetics, 101 Reykjavik, Iceland</aff><aff id="A30"><label>30</label>Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands</aff><aff id="A31"><label>31</label>Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, D-68167 Mannheim, Germany</aff><aff id="A32"><label>32</label>LURIC Study nonprofit LLC, D-79098 Freiburg, Germany</aff><aff id="A33"><label>33</label>Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford OX3 7LJ, UK</aff><aff id="A34"><label>34</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</aff><aff id="A35"><label>35</label>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK</aff><aff id="A36"><label>36</label>Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</aff><aff id="A37"><label>37</label>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK</aff><aff id="A38"><label>38</label>Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital, FIN-33521 Tampere, Finland</aff><aff id="A39"><label>39</label>Department of Clinical Chemistry, University of Tampere School of Medicine, FIN-33521 Tampere, Finland</aff><aff id="A40"><label>40</label>Department of Clinical Sciences, Lund University, SE-205 02Malmö, Sweden</aff><aff id="A41"><label>41</label>Institute of Population Genetics, National Research Council of Italy, 07100 Sassari, Italy</aff><aff id="A42"><label>42</label>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</aff><aff id="A43"><label>43</label>Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom</aff><aff id="A44"><label>44</label>University of Maryland School of Medicine, Baltimore, Maryland 21201, USA</aff><aff id="A45"><label>45</label>Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy</aff><aff id="A46"><label>46</label>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</aff><aff id="A47"><label>47</label>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</aff><aff id="A48"><label>48</label>Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia</aff><aff id="A49"><label>49</label>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald, Germany</aff><aff id="A50"><label>50</label>Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy</aff><aff id="A51"><label>51</label>Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”- Trieste, 34137 Trieste, Italy</aff><aff id="A52"><label>52</label>University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia</aff><aff id="A53"><label>53</label>Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Villejuif F-94807, France</aff><aff id="A54"><label>54</label>University Paris Sud 11, UMRS 1018, Villejuif F-94807, France</aff><aff id="A55"><label>55</label>Geriatric Unit, Azienda Sanitaria Firenze, 50125 Florence, Italy</aff><aff id="A56"><label>56</label>Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland</aff><aff id="A57"><label>57</label>Department of Internal Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland</aff><aff id="A58"><label>58</label>Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia</aff><aff id="A59"><label>59</label>Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, Ulm D-89075, Germany</aff><aff id="A60"><label>60</label>The Hatter Cardiovascular Institute, University College London, London WC1E 6HX, UK</aff><aff id="A61"><label>61</label>Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA</aff><aff id="A62"><label>62</label>Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</aff><aff id="A63"><label>63</label>Nutrition and Dietetics, Harokopio University, Kallithea 17671, Athens, Greece</aff><aff id="A64"><label>64</label>Institute of Epidemiology I and Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</aff><aff id="A65"><label>65</label>The Laboratory in Mjodd, 108 Reykjavik, Iceland</aff><aff id="A66"><label>66</label>Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21250, USA</aff><aff id="A67"><label>67</label>Instituto de Saúde Coletiva, Federal University of Bahia, Salvador, Bahia 40110-040, Brazil</aff><aff id="A68"><label>68</label>Medical Genetics Section, The University of Edinburgh, Edinburgh EH4 2XU, UK</aff><aff id="A69"><label>69</label>Institute of Clinical Sciences, Obstetrics and Gynecology, University of Oulu FIN-90220 Oulu, Finland</aff><aff id="A70"><label>70</label>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</aff><aff id="A71"><label>71</label>Hannover Unified Biobank, Hannover Medical School, D-30625 Hannover, Germany</aff><aff id="A72"><label>72</label>Department of Clinical Physiology, Tampere University Hospital, FIN-33521 Tampere, Finland</aff><aff id="A73"><label>73</label>Department of Clinical Physiology, University of Tampere School of Medicine, FIN-33521 Tampere, Finland</aff><aff id="A74"><label>74</label>Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</aff><aff id="A75"><label>75</label>Department of Epidemiology, Department of Biostatistics, Harvard School of Public Health, Cambridge, Massachusetts 02115, USA</aff><aff id="A76"><label>76</label>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany</aff><aff id="A77"><label>77</label>Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK</aff><aff id="A78"><label>78</label>Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</aff><aff id="A79"><label>79</label>Department of Clinical Biochemistry, Landspitali University Hospital, 101 Reykjavik, Iceland</aff><aff id="A80"><label>80</label>Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland</aff><aff id="A81"><label>81</label>Laboratory of Hematology and Coagulation Disorder Center, Landspitali University Hospital, 101 Reykjavik, Iceland</aff><aff id="A82"><label>82</label>Genetic Park of Ogliastra, Perdasdefogu, Sardinia, Italy</aff><aff id="A83"><label>83</label>Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam, The Netherlands</aff><aff id="A84"><label>84</label>Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</aff><aff id="A85"><label>85</label>Department of Psychiatry, Leiden University Medical Centre, 2333 Leiden, The Netherlands</aff><aff id="A86"><label>86</label>Division of Pediatrics and Thalassemia Centre, Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, Turin, Italy</aff><aff id="A87"><label>87</label>Institute of Health Sciences, University of Oulu, FIN-90220 Oulu, Finland</aff><aff id="A88"><label>88</label>National Institute of Health and Welfare, Aapistie 1, P.O. Box 310, FIN-90101 Oulu, Finland</aff><aff id="A89"><label>89</label>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FIN-20521 Turku, Finland</aff><aff id="A90"><label>90</label>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FIN-20521 Turku, Finland</aff><aff id="A91"><label>91</label>The School of Social and Community Medicine, University of Bristol, Bristol BS82PS, UK</aff><aff id="A92"><label>92</label>Institute of Diagnostics, University of Oulu, FIN-90014 Oulu, Finland</aff><aff id="A93"><label>93</label>Competence Centre on Reproductive Medicine and Biology, 50410 Tartu, Estonia</aff><aff id="A94"><label>94</label>Institute of General and Molecular Pathology, University of Tartu, 51014 Tartu, Estonia</aff><aff id="A95"><label>95</label>Department of Experimental Hematology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</aff><aff id="A96"><label>96</label>Department of Stem Cell Biology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</aff><aff id="A97"><label>97</label>Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany</aff><aff id="A98"><label>98</label>Departments of Human Genetics and Medicine, Faculty of Medicine, McGill University, Montreal, Quebec H3A 1B1, Canada</aff><aff id="A99"><label>99</label>Geriatric Medicine Unit, The University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK</aff><aff id="A100"><label>100</label>Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland</aff><aff id="A101"><label>101</label>Clin Phenomics Study Center, D-60594 Frankfurt, Germany</aff><aff id="A102"><label>102</label>Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands</aff><aff id="A103"><label>103</label>Dipartimento di Scienze Biomediche, Università di Sassari, 07100 Sassari, Italy</aff><aff id="A104"><label>104</label>Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK</aff><aff id="A105"><label>105</label>MRC-HPA Centre for Environment and Health, Imperial College London, London W2 1PG, UK</aff><aff id="A106"><label>106</label>Department of Cancer Biology, Thomas Jefferson University Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA</aff><aff id="A107"><label>107</label>Dipartimento di Medicina Molecolare, Università La Sapienza, 00161 Roma, Italy</aff><aff id="A108"><label>108</label>Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59100, France</aff><aff id="A109"><label>109</label>Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W2 1PG, UK</aff><aff id="A110"><label>110</label>Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, D-17487 Greifswald, Germany</aff><aff id="A111"><label>111</label>Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA</aff><aff id="A112"><label>112</label>Department of Lifecourse snd Service, National Institute for Health and Welfare, FIN-90101 Oulu, Finland</aff><aff id="A113"><label>113</label>Biocenter Oulu, University of Oulu, FIN-90220 Oulu, Finland</aff><aff id="A114"><label>114</label>Clinical Gerontology Unit, Box 251, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK</aff><aff id="A115"><label>115</label>Synlab Academy, D-68165 Mannheim, Germany</aff><aff id="A116"><label>116</label>Department of Internal Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</aff><aff id="A117"><label>117</label>Department of Neurology, General Central Hospital, 39100 Bolzano, Italy</aff><aff id="A118"><label>118</label>Department of Neurology, University of Lübeck, D-23538 Lübeck, Germany</aff><aff id="A119"><label>119</label>Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York 10029-6574, USA</aff><aff id="A120"><label>120</label>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland 21201, USA</aff><aff id="A121"><label>121</label>Department of Cardiology, Lund University, 22185 Lund, Sweden</aff><aff id="A122"><label>122</label>Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK</aff><aff id="A123"><label>123</label>Department of Medicine, University of Leipzig, Liebigstr. 18, D-04103 Leipzig, Germany</aff><aff id="A124"><label>124</label>University of Leipzig, IFB Adiposity Diseases, D-04103 Leipzig, Germany</aff><aff id="A125"><label>125</label>Insitute of Molecular Genetics, CNR, 27100 Pavia, Italy</aff><aff id="A126"><label>126</label>Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands</aff><aff id="A127"><label>127</label>Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland</aff><aff id="A128"><label>128</label>Imperial College Healthcare NHS Trust, London W12 0HS, UK</aff><author-notes><corresp id="FN1">Correspondence and requests for materials should be addressed to J.C.C. (<email>john.chambers@ic.ac.uk</email>), C.G. (<email>christian.gieger@helmholtz-muenchen.de</email>), P.v.d.H. (<email>p.van.der.harst@umcg.nl</email>), J.S.K. (<email>j.kooner@ic.ac.uk</email>), W.H.O. (<email>who1000@cam.ac.uk</email>) and N.S. (<email>ns6@sanger.ac.uk</email>)</corresp><fn id="FN2" fn-type="equal"><label>*</label><p>These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>18</day><month>3</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>05</day><month>12</month><year>2012</year></pub-date><pub-date pub-type="ppub"><day>20</day><month>12</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>11</day><month>4</month><year>2013</year></pub-date><volume>492</volume><issue>7429</issue><fpage>369</fpage><lpage>375</lpage><permissions><copyright-statement>© 2012 Macmillan Publishers Limited. All rights reserved</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><p id="P1">Anaemia is a chief determinant of globalill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at <italic>P</italic> <10<sup>−8</sup>, which together explain 4–9% of the phenotypic variance per trait. Using expression quantitative trait loci and bioinformatic strategies, we identify 121 candidate genes enriched in functions relevant to red blood cell biology. The candidate genes are expressed preferentially in red blood cell precursors, and 43 have haematopoietic phenotypes in <italic>Mus musculus</italic> or <italic>Drosophila melanogaster</italic>. Through open-chromatin and coding-variant analyses we identify potential causal genetic variants at 41 loci. Our findings provide extensive new insights into genetic mechanisms and biological pathways controlling red blood cell formation and function.</p></abstract><funding-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>HHSN268201100012C || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>HHSN268201100011C || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>HHSN268201100010C || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>HHSN268201100009C || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>HHSN268201100008C || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>HHSN268201100007C || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>HHSN268201100006C || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>HHSN268201100005C || HL</award-id></award-group><award-group><funding-source country="United States">National Center for Research Resources : NCRR</funding-source><award-id>UL1 RR025005 || RR</award-id></award-group><award-group><funding-source country="United States">National Center for Research Resources : NCRR</funding-source><award-id>U54 RR020278 || RR</award-id></award-group><award-group><funding-source country="United 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