“Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes”
Identifieur interne : 001D23 ( Pmc/Corpus ); précédent : 001D22; suivant : 001D24“Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes”
Auteurs : Daniel E. Neafsey ; Robert M. Waterhouse ; Mohammad R. Abai ; Sergey S. Aganezov ; Max A. Alekseyev ; James E. Allen ; James Amon ; Bruno Arcà ; Peter Arensburger ; Gleb Artemov ; Lauren A. Assour ; Hamidreza Basseri ; Aaron Berlin ; Bruce W. Birren ; Stephanie A. Blandin ; Andrew I. Brockman ; Thomas R. Burkot ; Austin Burt ; Clara S. Chan ; Cedric Chauve ; Joanna C. Chiu ; Mikkel Christensen ; Carlo Costantini ; Victoria L. M. Davidson ; Elena Deligianni ; Tania Dottorini ; Vicky Dritsou ; Stacey B. Gabriel ; Wamdaogo M. Guelbeogo ; Andrew B. Hall ; Mira V. Han ; Thaung Hlaing ; Daniel S. T. Hughes ; Adam M. Jenkins ; Xiaofang Jiang ; Irwin Jungreis ; Evdoxia G. Kakani ; Maryam Kamali ; Petri Kemppainen ; Ryan C. Kennedy ; Ioannis K. Kirmitzoglou ; Lizette L. Koekemoer ; Njoroge Laban ; Nicholas Langridge ; Mara K. N. Lawniczak ; Manolis Lirakis ; Neil F. Lobo ; Ernesto Lowy ; Robert M. Maccallum ; Chunhong Mao ; Gareth Maslen ; Charles Mbogo ; Jenny Mccarthy ; Kristin Michel ; Sara N. Mitchell ; Wendy Moore ; Katherine A. Murphy ; Anastasia N. Naumenko ; Tony Nolan ; Eva M. Novoa ; Samantha O'Loughlin ; Chioma Oringanje ; Mohammad A. Oshaghi ; Nazzy Pakpour ; Philippos A. Papathanos ; Ashley N. Peery ; Michael Povelones ; Anil Prakash ; David P. Price ; Ashok Rajaraman ; Lisa J. Reimer ; David C. Rinker ; Antonis Rokas ; Tanya L. Russell ; N'Fale Sagnon ; Maria V. Sharakhova ; Terrance Shea ; Felipe A. Simão ; Frederic Simard ; Michel A. Slotman ; Pradya Somboon ; Vladimir Stegniy ; Claudio J. Struchiner ; Gregg W. C. Thomas ; Marta Tojo ; Pantelis Topalis ; José M. C. Tubio ; Maria F. Unger ; John Vontas ; Catherine Walton ; Craig S. Wilding ; Judith H. Willis ; Yi-Chieh Wu ; Guiyun Yan ; Evgeny M. Zdobnov ; Xiaofan Zhou ; Flaminia Catteruccia ; George K. Christophides ; Frank H. Collins ; Robert S. Cornman ; Andrea Crisanti ; Martin J. Donnelly ; Scott J. Emrich ; Michael C. Fontaine ; William Gelbart ; Matthew W. Hahn ; Immo A. Hansen ; Paul I. Howell ; Fotis C. Kafatos ; Manolis Kellis ; Daniel Lawson ; Christos Louis ; Shirley Luckhart ; Marc A. T. Muskavitch ; José M. Ribeiro ; Michael A. Riehle ; Igor V. Sharakhov ; Zhijian Tu ; Laurence J. Zwiebel ; Nora J. BesanskySource :
- Science (New York, N.Y.) [ 0036-8075 ] ; 2014.
Abstract
Variation in vectorial capacity for human malaria among
Url:
DOI: 10.1126/science.1258522
PubMed: 25554792
PubMed Central: 4380271
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PMC:4380271Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">“Highly evolvable malaria vectors: the genomes of 16 <italic>Anopheles</italic> mosquitoes”</title><author><name sortKey="Neafsey, Daniel E" sort="Neafsey, Daniel E" uniqKey="Neafsey D" first="Daniel E." last="Neafsey">Daniel E. Neafsey</name><affiliation><nlm:aff id="A1">Genome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Waterhouse, Robert M" sort="Waterhouse, Robert M" uniqKey="Waterhouse R" first="Robert M." last="Waterhouse">Robert M. Waterhouse</name><affiliation><nlm:aff id="A2">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Genetic Medicine and Development, University of Geneva Medical School, rue Michel-Servet 1, 1211, Geneva, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Swiss Institute of Bioinformatics, rue Michel-Servet 1, 1211 Geneva, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Abai, Mohammad R" sort="Abai, Mohammad R" uniqKey="Abai M" first="Mohammad R." last="Abai">Mohammad R. Abai</name><affiliation><nlm:aff id="A6">Department of Medical Entomology and Vector Control, School of Public Health and Institute of Health Researches, Tehran University of Medical Sciences, Tehran, Iran.</nlm:aff></affiliation></author><author><name sortKey="Aganezov, Sergey S" sort="Aganezov, Sergey S" uniqKey="Aganezov S" first="Sergey S." last="Aganezov">Sergey S. Aganezov</name><affiliation><nlm:aff id="A7">George Washington University, Department of Mathematics and Computational Biology Institute, 45085 University Drive, Ashburn, VA 20147, USA.</nlm:aff></affiliation></author><author><name sortKey="Alekseyev, Max A" sort="Alekseyev, Max A" uniqKey="Alekseyev M" first="Max A." last="Alekseyev">Max A. Alekseyev</name><affiliation><nlm:aff id="A7">George Washington University, Department of Mathematics and Computational Biology Institute, 45085 University Drive, Ashburn, VA 20147, USA.</nlm:aff></affiliation></author><author><name sortKey="Allen, James E" sort="Allen, James E" uniqKey="Allen J" first="James E." last="Allen">James E. Allen</name><affiliation><nlm:aff id="A8">European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Amon, James" sort="Amon, James" uniqKey="Amon J" first="James" last="Amon">James Amon</name><affiliation><nlm:aff id="A9">National Vector Borne Disease Control Programme, Ministry of Health, Tafea Province, Vanuatu.</nlm:aff></affiliation></author><author><name sortKey="Arca, Bruno" sort="Arca, Bruno" uniqKey="Arca B" first="Bruno" last="Arcà">Bruno Arcà</name><affiliation><nlm:aff id="A10">Department of Public Health and Infectious Diseases, Division of Parasitology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.</nlm:aff></affiliation></author><author><name sortKey="Arensburger, Peter" sort="Arensburger, Peter" uniqKey="Arensburger P" first="Peter" last="Arensburger">Peter Arensburger</name><affiliation><nlm:aff id="A11">Department of Biological Sciences, Cal Poly Pomona, 3801 West Temple Avenue, Pomona, CA 91768, USA.</nlm:aff></affiliation></author><author><name sortKey="Artemov, Gleb" sort="Artemov, Gleb" uniqKey="Artemov G" first="Gleb" last="Artemov">Gleb Artemov</name><affiliation><nlm:aff id="A12">Tomsk State University, 36 Lenina avenue, Tomsk, Russia.</nlm:aff></affiliation></author><author><name sortKey="Assour, Lauren A" sort="Assour, Lauren A" uniqKey="Assour L" first="Lauren A." last="Assour">Lauren A. Assour</name><affiliation><nlm:aff id="A13">Department of Computer Science and Engineering, Eck Institute for Global Health, 211B Cushing Hall, University of Notre Dame, Notre Dame, IN 46556, USA.</nlm:aff></affiliation></author><author><name sortKey="Basseri, Hamidreza" sort="Basseri, Hamidreza" uniqKey="Basseri H" first="Hamidreza" last="Basseri">Hamidreza Basseri</name><affiliation><nlm:aff id="A6">Department of Medical Entomology and Vector Control, School of Public Health and Institute of Health Researches, Tehran University of Medical Sciences, Tehran, Iran.</nlm:aff></affiliation></author><author><name sortKey="Berlin, Aaron" sort="Berlin, Aaron" uniqKey="Berlin A" first="Aaron" last="Berlin">Aaron Berlin</name><affiliation><nlm:aff id="A1">Genome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Birren, Bruce W" sort="Birren, Bruce W" uniqKey="Birren B" first="Bruce W." last="Birren">Bruce W. Birren</name><affiliation><nlm:aff id="A1">Genome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Blandin, Stephanie A" sort="Blandin, Stephanie A" uniqKey="Blandin S" first="Stephanie A." last="Blandin">Stephanie A. Blandin</name><affiliation><nlm:aff id="A14">Inserm, U963, Immune responses in the malaria vector A. gambiae, F-67084, Strasbourg, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A15">CNRS, UPR9022, Immune responses and development in insects, IBMC, F-67084, Strasbourg, France.</nlm:aff></affiliation></author><author><name sortKey="Brockman, Andrew I" sort="Brockman, Andrew I" uniqKey="Brockman A" first="Andrew I." last="Brockman">Andrew I. Brockman</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation></author><author><name sortKey="Burkot, Thomas R" sort="Burkot, Thomas R" uniqKey="Burkot T" first="Thomas R." last="Burkot">Thomas R. Burkot</name><affiliation><nlm:aff id="A17">Faculty of Medicine, Health and Molecular Science, Australian Institute of Tropical Health Medicine, James Cook University, Cairns 4870, Australia.</nlm:aff></affiliation></author><author><name sortKey="Burt, Austin" sort="Burt, Austin" uniqKey="Burt A" first="Austin" last="Burt">Austin Burt</name><affiliation><nlm:aff id="A18">Department of Life Sciences, Imperial College London, Silwood Park Campus, Ascot SL5 7PY, UK.</nlm:aff></affiliation></author><author><name sortKey="Chan, Clara S" sort="Chan, Clara S" uniqKey="Chan C" first="Clara S." last="Chan">Clara S. Chan</name><affiliation><nlm:aff id="A2">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Chauve, Cedric" sort="Chauve, Cedric" uniqKey="Chauve C" first="Cedric" last="Chauve">Cedric Chauve</name><affiliation><nlm:aff id="A19">Department of Mathematics, Simon Fraser University, 8888 University Drive, Burnaby BC, V5A1S6, Canada.</nlm:aff></affiliation></author><author><name sortKey="Chiu, Joanna C" sort="Chiu, Joanna C" uniqKey="Chiu J" first="Joanna C." last="Chiu">Joanna C. Chiu</name><affiliation><nlm:aff id="A20">Department of Entomology and Nematology, One Shields Avenue, UC Davis, Davis, CA 95616, USA.</nlm:aff></affiliation></author><author><name sortKey="Christensen, Mikkel" sort="Christensen, Mikkel" uniqKey="Christensen M" first="Mikkel" last="Christensen">Mikkel Christensen</name><affiliation><nlm:aff id="A8">European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Costantini, Carlo" sort="Costantini, Carlo" uniqKey="Costantini C" first="Carlo" last="Costantini">Carlo Costantini</name><affiliation><nlm:aff id="A21">Institut de Recherche pour le Développement, UMR MIVEGEC, 911, Avenue Agropolis, BP 64501 Montpellier, France.</nlm:aff></affiliation></author><author><name sortKey="Davidson, Victoria L M" sort="Davidson, Victoria L M" uniqKey="Davidson V" first="Victoria L. M." last="Davidson">Victoria L. M. Davidson</name><affiliation><nlm:aff id="A22">Division of Biology, Kansas State University, 271 Chalmers Hall, Manhattan, KS 66506, USA.</nlm:aff></affiliation></author><author><name sortKey="Deligianni, Elena" sort="Deligianni, Elena" uniqKey="Deligianni E" first="Elena" last="Deligianni">Elena Deligianni</name><affiliation><nlm:aff id="A23">Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, Nikolaou Plastira 100 GR-70013, Heraklion, Crete, Greece.</nlm:aff></affiliation></author><author><name sortKey="Dottorini, Tania" sort="Dottorini, Tania" uniqKey="Dottorini T" first="Tania" last="Dottorini">Tania Dottorini</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation></author><author><name sortKey="Dritsou, Vicky" sort="Dritsou, Vicky" uniqKey="Dritsou V" first="Vicky" last="Dritsou">Vicky Dritsou</name><affiliation><nlm:aff id="A24">Centre of Functional Genomics, University of Perugia, Perugia, Italy.</nlm:aff></affiliation></author><author><name sortKey="Gabriel, Stacey B" sort="Gabriel, Stacey B" uniqKey="Gabriel S" first="Stacey B." last="Gabriel">Stacey B. Gabriel</name><affiliation><nlm:aff id="A25">Genomics Platform, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Guelbeogo, Wamdaogo M" sort="Guelbeogo, Wamdaogo M" uniqKey="Guelbeogo W" first="Wamdaogo M." last="Guelbeogo">Wamdaogo M. Guelbeogo</name><affiliation><nlm:aff id="A26">Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou 01 BP 2208, Burkina Faso.</nlm:aff></affiliation></author><author><name sortKey="Hall, Andrew B" sort="Hall, Andrew B" uniqKey="Hall A" first="Andrew B." last="Hall">Andrew B. Hall</name><affiliation><nlm:aff id="A27">Program of Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Han, Mira V" sort="Han, Mira V" uniqKey="Han M" first="Mira V." last="Han">Mira V. Han</name><affiliation><nlm:aff id="A28">School of Life Sciences, University of Nevada, Las Vegas, NV 89154, USA.</nlm:aff></affiliation></author><author><name sortKey="Hlaing, Thaung" sort="Hlaing, Thaung" uniqKey="Hlaing T" first="Thaung" last="Hlaing">Thaung Hlaing</name><affiliation><nlm:aff id="A29">Department of Medical Research, No. 5, Ziwaka Road, Dagon Township, Yangon 11191, Myanmar.</nlm:aff></affiliation></author><author><name sortKey="Hughes, Daniel S T" sort="Hughes, Daniel S T" uniqKey="Hughes D" first="Daniel S. T." last="Hughes">Daniel S. T. Hughes</name><affiliation><nlm:aff id="A8">European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.</nlm:aff></affiliation></author><author><name sortKey="Jenkins, Adam M" sort="Jenkins, Adam M" uniqKey="Jenkins A" first="Adam M." last="Jenkins">Adam M. Jenkins</name><affiliation><nlm:aff id="A31">Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA.</nlm:aff></affiliation></author><author><name sortKey="Jiang, Xiaofang" sort="Jiang, Xiaofang" uniqKey="Jiang X" first="Xiaofang" last="Jiang">Xiaofang Jiang</name><affiliation><nlm:aff id="A32">Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Program of Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Jungreis, Irwin" sort="Jungreis, Irwin" uniqKey="Jungreis I" first="Irwin" last="Jungreis">Irwin Jungreis</name><affiliation><nlm:aff id="A2">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Kakani, Evdoxia G" sort="Kakani, Evdoxia G" uniqKey="Kakani E" first="Evdoxia G." last="Kakani">Evdoxia G. Kakani</name><affiliation><nlm:aff id="A33">Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02115, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy.</nlm:aff></affiliation></author><author><name sortKey="Kamali, Maryam" sort="Kamali, Maryam" uniqKey="Kamali M" first="Maryam" last="Kamali">Maryam Kamali</name><affiliation><nlm:aff id="A35">Department of Entomology, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Kemppainen, Petri" sort="Kemppainen, Petri" uniqKey="Kemppainen P" first="Petri" last="Kemppainen">Petri Kemppainen</name><affiliation><nlm:aff id="A36">Computational Evolutionary Biology Group, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.</nlm:aff></affiliation></author><author><name sortKey="Kennedy, Ryan C" sort="Kennedy, Ryan C" uniqKey="Kennedy R" first="Ryan C." last="Kennedy">Ryan C. Kennedy</name><affiliation><nlm:aff id="A37">Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143, USA.</nlm:aff></affiliation></author><author><name sortKey="Kirmitzoglou, Ioannis K" sort="Kirmitzoglou, Ioannis K" uniqKey="Kirmitzoglou I" first="Ioannis K." last="Kirmitzoglou">Ioannis K. Kirmitzoglou</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Bioinformatics Research Laboratory, Department of Biological Sciences, New Campus, University of Cyprus, CY 1678, Nicosia, Cyprus.</nlm:aff></affiliation></author><author><name sortKey="Koekemoer, Lizette L" sort="Koekemoer, Lizette L" uniqKey="Koekemoer L" first="Lizette L." last="Koekemoer">Lizette L. Koekemoer</name><affiliation><nlm:aff id="A39">Wits Research Institute for Malaria, Faculty of Health Sciences, and Vector Control Reference Unit, National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham 2131, Johannesburg, South Africa.</nlm:aff></affiliation></author><author><name sortKey="Laban, Njoroge" sort="Laban, Njoroge" uniqKey="Laban N" first="Njoroge" last="Laban">Njoroge Laban</name><affiliation><nlm:aff id="A40">National Museums of Kenya, P.O. Box 40658-00100, Nairobi, Kenya.</nlm:aff></affiliation></author><author><name sortKey="Langridge, Nicholas" sort="Langridge, Nicholas" uniqKey="Langridge N" first="Nicholas" last="Langridge">Nicholas Langridge</name><affiliation><nlm:aff id="A8">European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Lawniczak, Mara K N" sort="Lawniczak, Mara K N" uniqKey="Lawniczak M" first="Mara K. N." last="Lawniczak">Mara K. N. Lawniczak</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation></author><author><name sortKey="Lirakis, Manolis" sort="Lirakis, Manolis" uniqKey="Lirakis M" first="Manolis" last="Lirakis">Manolis Lirakis</name><affiliation><nlm:aff id="A41">Department of Biology, University of Crete, 700 13 Heraklion, Greece.</nlm:aff></affiliation></author><author><name sortKey="Lobo, Neil F" sort="Lobo, Neil F" uniqKey="Lobo N" first="Neil F." last="Lobo">Neil F. Lobo</name><affiliation><nlm:aff id="A42">Eck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA.</nlm:aff></affiliation></author><author><name sortKey="Lowy, Ernesto" sort="Lowy, Ernesto" uniqKey="Lowy E" first="Ernesto" last="Lowy">Ernesto Lowy</name><affiliation><nlm:aff id="A8">European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Maccallum, Robert M" sort="Maccallum, Robert M" uniqKey="Maccallum R" first="Robert M." last="Maccallum">Robert M. Maccallum</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation></author><author><name sortKey="Mao, Chunhong" sort="Mao, Chunhong" uniqKey="Mao C" first="Chunhong" last="Mao">Chunhong Mao</name><affiliation><nlm:aff id="A43">Virginia Bioinformatics Institute, 1015 Life Science Circle, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Maslen, Gareth" sort="Maslen, Gareth" uniqKey="Maslen G" first="Gareth" last="Maslen">Gareth Maslen</name><affiliation><nlm:aff id="A8">European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Mbogo, Charles" sort="Mbogo, Charles" uniqKey="Mbogo C" first="Charles" last="Mbogo">Charles Mbogo</name><affiliation><nlm:aff id="A44">KEMRI-Wellcome Trust Research Programme, CGMRC, PO Box 230-80108, Kilifi, Kenya.</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Jenny" sort="Mccarthy, Jenny" uniqKey="Mccarthy J" first="Jenny" last="Mccarthy">Jenny Mccarthy</name><affiliation><nlm:aff id="A11">Department of Biological Sciences, Cal Poly Pomona, 3801 West Temple Avenue, Pomona, CA 91768, USA.</nlm:aff></affiliation></author><author><name sortKey="Michel, Kristin" sort="Michel, Kristin" uniqKey="Michel K" first="Kristin" last="Michel">Kristin Michel</name><affiliation><nlm:aff id="A22">Division of Biology, Kansas State University, 271 Chalmers Hall, Manhattan, KS 66506, USA.</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Sara N" sort="Mitchell, Sara N" uniqKey="Mitchell S" first="Sara N." last="Mitchell">Sara N. Mitchell</name><affiliation><nlm:aff id="A33">Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02115, USA.</nlm:aff></affiliation></author><author><name sortKey="Moore, Wendy" sort="Moore, Wendy" uniqKey="Moore W" first="Wendy" last="Moore">Wendy Moore</name><affiliation><nlm:aff id="A45">Department of Entomology, 1140 E. South Campus Drive, Forbes 410, University of Arizona, Tucson, AZ 85721, USA.</nlm:aff></affiliation></author><author><name sortKey="Murphy, Katherine A" sort="Murphy, Katherine A" uniqKey="Murphy K" first="Katherine A." last="Murphy">Katherine A. Murphy</name><affiliation><nlm:aff id="A20">Department of Entomology and Nematology, One Shields Avenue, UC Davis, Davis, CA 95616, USA.</nlm:aff></affiliation></author><author><name sortKey="Naumenko, Anastasia N" sort="Naumenko, Anastasia N" uniqKey="Naumenko A" first="Anastasia N." last="Naumenko">Anastasia N. Naumenko</name><affiliation><nlm:aff id="A35">Department of Entomology, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Nolan, Tony" sort="Nolan, Tony" uniqKey="Nolan T" first="Tony" last="Nolan">Tony Nolan</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation></author><author><name sortKey="Novoa, Eva M" sort="Novoa, Eva M" uniqKey="Novoa E" first="Eva M." last="Novoa">Eva M. Novoa</name><affiliation><nlm:aff id="A2">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="O Loughlin, Samantha" sort="O Loughlin, Samantha" uniqKey="O Loughlin S" first="Samantha" last="O'Loughlin">Samantha O'Loughlin</name><affiliation><nlm:aff id="A18">Department of Life Sciences, Imperial College London, Silwood Park Campus, Ascot SL5 7PY, UK.</nlm:aff></affiliation></author><author><name sortKey="Oringanje, Chioma" sort="Oringanje, Chioma" uniqKey="Oringanje C" first="Chioma" last="Oringanje">Chioma Oringanje</name><affiliation><nlm:aff id="A45">Department of Entomology, 1140 E. South Campus Drive, Forbes 410, University of Arizona, Tucson, AZ 85721, USA.</nlm:aff></affiliation></author><author><name sortKey="Oshaghi, Mohammad A" sort="Oshaghi, Mohammad A" uniqKey="Oshaghi M" first="Mohammad A." last="Oshaghi">Mohammad A. Oshaghi</name><affiliation><nlm:aff id="A6">Department of Medical Entomology and Vector Control, School of Public Health and Institute of Health Researches, Tehran University of Medical Sciences, Tehran, Iran.</nlm:aff></affiliation></author><author><name sortKey="Pakpour, Nazzy" sort="Pakpour, Nazzy" uniqKey="Pakpour N" first="Nazzy" last="Pakpour">Nazzy Pakpour</name><affiliation><nlm:aff id="A46">Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.</nlm:aff></affiliation></author><author><name sortKey="Papathanos, Philippos A" sort="Papathanos, Philippos A" uniqKey="Papathanos P" first="Philippos A." last="Papathanos">Philippos A. Papathanos</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Centre of Functional Genomics, University of Perugia, Perugia, Italy.</nlm:aff></affiliation></author><author><name sortKey="Peery, Ashley N" sort="Peery, Ashley N" uniqKey="Peery A" first="Ashley N." last="Peery">Ashley N. Peery</name><affiliation><nlm:aff id="A35">Department of Entomology, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Povelones, Michael" sort="Povelones, Michael" uniqKey="Povelones M" first="Michael" last="Povelones">Michael Povelones</name><affiliation><nlm:aff id="A47">Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA.</nlm:aff></affiliation></author><author><name sortKey="Prakash, Anil" sort="Prakash, Anil" uniqKey="Prakash A" first="Anil" last="Prakash">Anil Prakash</name><affiliation><nlm:aff id="A48">Regional Medical Research Centre NE, Indian Council of Medical Research, PO Box 105, Dibrugarh-786 001, Assam, India.</nlm:aff></affiliation></author><author><name sortKey="Price, David P" sort="Price, David P" uniqKey="Price D" first="David P." last="Price">David P. Price</name><affiliation><nlm:aff id="A49">Department of Biology, New Mexico State University, NM 88003, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Molecular Biology Program, New Mexico State University, Las Cruces, NM 88003, USA.</nlm:aff></affiliation></author><author><name sortKey="Rajaraman, Ashok" sort="Rajaraman, Ashok" uniqKey="Rajaraman A" first="Ashok" last="Rajaraman">Ashok Rajaraman</name><affiliation><nlm:aff id="A19">Department of Mathematics, Simon Fraser University, 8888 University Drive, Burnaby BC, V5A1S6, Canada.</nlm:aff></affiliation></author><author><name sortKey="Reimer, Lisa J" sort="Reimer, Lisa J" uniqKey="Reimer L" first="Lisa J." last="Reimer">Lisa J. Reimer</name><affiliation><nlm:aff id="A51">Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L35QA, UK.</nlm:aff></affiliation></author><author><name sortKey="Rinker, David C" sort="Rinker, David C" uniqKey="Rinker D" first="David C." last="Rinker">David C. Rinker</name><affiliation><nlm:aff id="A52">Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37235, USA.</nlm:aff></affiliation></author><author><name sortKey="Rokas, Antonis" sort="Rokas, Antonis" uniqKey="Rokas A" first="Antonis" last="Rokas">Antonis Rokas</name><affiliation><nlm:aff id="A52">Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37235, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.</nlm:aff></affiliation></author><author><name sortKey="Russell, Tanya L" sort="Russell, Tanya L" uniqKey="Russell T" first="Tanya L." last="Russell">Tanya L. Russell</name><affiliation><nlm:aff id="A17">Faculty of Medicine, Health and Molecular Science, Australian Institute of Tropical Health Medicine, James Cook University, Cairns 4870, Australia.</nlm:aff></affiliation></author><author><name sortKey="Sagnon, N Fale" sort="Sagnon, N Fale" uniqKey="Sagnon N" first="N'Fale" last="Sagnon">N'Fale Sagnon</name><affiliation><nlm:aff id="A26">Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou 01 BP 2208, Burkina Faso.</nlm:aff></affiliation></author><author><name sortKey="Sharakhova, Maria V" sort="Sharakhova, Maria V" uniqKey="Sharakhova M" first="Maria V." last="Sharakhova">Maria V. Sharakhova</name><affiliation><nlm:aff id="A35">Department of Entomology, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Shea, Terrance" sort="Shea, Terrance" uniqKey="Shea T" first="Terrance" last="Shea">Terrance Shea</name><affiliation><nlm:aff id="A1">Genome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Simao, Felipe A" sort="Simao, Felipe A" uniqKey="Simao F" first="Felipe A." last="Simão">Felipe A. Simão</name><affiliation><nlm:aff id="A4">Department of Genetic Medicine and Development, University of Geneva Medical School, rue Michel-Servet 1, 1211, Geneva, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Swiss Institute of Bioinformatics, rue Michel-Servet 1, 1211 Geneva, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Simard, Frederic" sort="Simard, Frederic" uniqKey="Simard F" first="Frederic" last="Simard">Frederic Simard</name><affiliation><nlm:aff id="A21">Institut de Recherche pour le Développement, UMR MIVEGEC, 911, Avenue Agropolis, BP 64501 Montpellier, France.</nlm:aff></affiliation></author><author><name sortKey="Slotman, Michel A" sort="Slotman, Michel A" uniqKey="Slotman M" first="Michel A." last="Slotman">Michel A. Slotman</name><affiliation><nlm:aff id="A54">Department of Entomology, Texas A&M University, College Station, TX 77807, USA.</nlm:aff></affiliation></author><author><name sortKey="Somboon, Pradya" sort="Somboon, Pradya" uniqKey="Somboon P" first="Pradya" last="Somboon">Pradya Somboon</name><affiliation><nlm:aff id="A55">Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.</nlm:aff></affiliation></author><author><name sortKey="Stegniy, Vladimir" sort="Stegniy, Vladimir" uniqKey="Stegniy V" first="Vladimir" last="Stegniy">Vladimir Stegniy</name><affiliation><nlm:aff id="A12">Tomsk State University, 36 Lenina avenue, Tomsk, Russia.</nlm:aff></affiliation></author><author><name sortKey="Struchiner, Claudio J" sort="Struchiner, Claudio J" uniqKey="Struchiner C" first="Claudio J." last="Struchiner">Claudio J. Struchiner</name><affiliation><nlm:aff id="A56">Fundação Oswaldo Cruz, Av Brasil 4365, RJ Brazil.</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Instituto de Medicina Social, UERJ, Rio de Janeiro, Brazil.</nlm:aff></affiliation></author><author><name sortKey="Thomas, Gregg W C" sort="Thomas, Gregg W C" uniqKey="Thomas G" first="Gregg W. C." last="Thomas">Gregg W. C. Thomas</name><affiliation><nlm:aff id="A58">School of Informatics and Computing, Indiana University, Bloomington, IN 47405, USA.</nlm:aff></affiliation></author><author><name sortKey="Tojo, Marta" sort="Tojo, Marta" uniqKey="Tojo M" first="Marta" last="Tojo">Marta Tojo</name><affiliation><nlm:aff id="A59">Department of Physiology, School of Medicine, CIMUS, Instituto de Investigaciones, Sanitarias, University of Santiago de Compostela, Spain.</nlm:aff></affiliation></author><author><name sortKey="Topalis, Pantelis" sort="Topalis, Pantelis" uniqKey="Topalis P" first="Pantelis" last="Topalis">Pantelis Topalis</name><affiliation><nlm:aff id="A23">Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, Nikolaou Plastira 100 GR-70013, Heraklion, Crete, Greece.</nlm:aff></affiliation></author><author><name sortKey="Tubio, Jose M C" sort="Tubio, Jose M C" uniqKey="Tubio J" first="José M. C." last="Tubio">José M. C. Tubio</name><affiliation><nlm:aff id="A60">Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK.</nlm:aff></affiliation></author><author><name sortKey="Unger, Maria F" sort="Unger, Maria F" uniqKey="Unger M" first="Maria F." last="Unger">Maria F. Unger</name><affiliation><nlm:aff id="A42">Eck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA.</nlm:aff></affiliation></author><author><name sortKey="Vontas, John" sort="Vontas, John" uniqKey="Vontas J" first="John" last="Vontas">John Vontas</name><affiliation><nlm:aff id="A41">Department of Biology, University of Crete, 700 13 Heraklion, Greece.</nlm:aff></affiliation></author><author><name sortKey="Walton, Catherine" sort="Walton, Catherine" uniqKey="Walton C" first="Catherine" last="Walton">Catherine Walton</name><affiliation><nlm:aff id="A36">Computational Evolutionary Biology Group, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.</nlm:aff></affiliation></author><author><name sortKey="Wilding, Craig S" sort="Wilding, Craig S" uniqKey="Wilding C" first="Craig S." last="Wilding">Craig S. Wilding</name><affiliation><nlm:aff id="A61">School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, L3 3AF, UK.</nlm:aff></affiliation></author><author><name sortKey="Willis, Judith H" sort="Willis, Judith H" uniqKey="Willis J" first="Judith H." last="Willis">Judith H. Willis</name><affiliation><nlm:aff id="A62">Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA.</nlm:aff></affiliation></author><author><name sortKey="Wu, Yi Chieh" sort="Wu, Yi Chieh" uniqKey="Wu Y" first="Yi-Chieh" last="Wu">Yi-Chieh Wu</name><affiliation><nlm:aff id="A2">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Department of Computer Science, Harvey Mudd College, Claremont, CA 91711, USA.</nlm:aff></affiliation></author><author><name sortKey="Yan, Guiyun" sort="Yan, Guiyun" uniqKey="Yan G" first="Guiyun" last="Yan">Guiyun Yan</name><affiliation><nlm:aff id="A64">Program in Public Health, College of Health Sciences, University of California, Irvine, Hewitt Hall, Irvine, CA 92697, USA.</nlm:aff></affiliation></author><author><name sortKey="Zdobnov, Evgeny M" sort="Zdobnov, Evgeny M" uniqKey="Zdobnov E" first="Evgeny M." last="Zdobnov">Evgeny M. Zdobnov</name><affiliation><nlm:aff id="A4">Department of Genetic Medicine and Development, University of Geneva Medical School, rue Michel-Servet 1, 1211, Geneva, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Swiss Institute of Bioinformatics, rue Michel-Servet 1, 1211 Geneva, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Zhou, Xiaofan" sort="Zhou, Xiaofan" uniqKey="Zhou X" first="Xiaofan" last="Zhou">Xiaofan Zhou</name><affiliation><nlm:aff id="A53">Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.</nlm:aff></affiliation></author><author><name sortKey="Catteruccia, Flaminia" sort="Catteruccia, Flaminia" uniqKey="Catteruccia F" first="Flaminia" last="Catteruccia">Flaminia Catteruccia</name><affiliation><nlm:aff id="A33">Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02115, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy.</nlm:aff></affiliation></author><author><name sortKey="Christophides, George K" sort="Christophides, George K" uniqKey="Christophides G" first="George K." last="Christophides">George K. Christophides</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation></author><author><name sortKey="Collins, Frank H" sort="Collins, Frank H" uniqKey="Collins F" first="Frank H." last="Collins">Frank H. Collins</name><affiliation><nlm:aff id="A42">Eck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA.</nlm:aff></affiliation></author><author><name sortKey="Cornman, Robert S" sort="Cornman, Robert S" uniqKey="Cornman R" first="Robert S." last="Cornman">Robert S. Cornman</name><affiliation><nlm:aff id="A62">Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA.</nlm:aff></affiliation></author><author><name sortKey="Crisanti, Andrea" sort="Crisanti, Andrea" uniqKey="Crisanti A" first="Andrea" last="Crisanti">Andrea Crisanti</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Centre of Functional Genomics, University of Perugia, Perugia, Italy.</nlm:aff></affiliation></author><author><name sortKey="Donnelly, Martin J" sort="Donnelly, Martin J" uniqKey="Donnelly M" first="Martin J." last="Donnelly">Martin J. Donnelly</name><affiliation><nlm:aff id="A51">Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L35QA, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Malaria Programme, Wellcome Trust Sanger Institute, Cambridge, CB10 1SJ, UK.</nlm:aff></affiliation></author><author><name sortKey="Emrich, Scott J" sort="Emrich, Scott J" uniqKey="Emrich S" first="Scott J." last="Emrich">Scott J. Emrich</name><affiliation><nlm:aff id="A13">Department of Computer Science and Engineering, Eck Institute for Global Health, 211B Cushing Hall, University of Notre Dame, Notre Dame, IN 46556, USA.</nlm:aff></affiliation></author><author><name sortKey="Fontaine, Michael C" sort="Fontaine, Michael C" uniqKey="Fontaine M" first="Michael C." last="Fontaine">Michael C. Fontaine</name><affiliation><nlm:aff id="A42">Eck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Centre of Evolutionary and Ecological Studies (CEES-MarECon group), University of Groningen, Nijenborgh 7, NL-9747 AG Groningen, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Gelbart, William" sort="Gelbart, William" uniqKey="Gelbart W" first="William" last="Gelbart">William Gelbart</name><affiliation><nlm:aff id="A67">Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave, Cambridge, MA 02138, USA.</nlm:aff></affiliation></author><author><name sortKey="Hahn, Matthew W" sort="Hahn, Matthew W" uniqKey="Hahn M" first="Matthew W." last="Hahn">Matthew W. Hahn</name><affiliation><nlm:aff id="A68">Department of Biology, Indiana University, Bloomington, IN 47405, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A58">School of Informatics and Computing, Indiana University, Bloomington, IN 47405, USA.</nlm:aff></affiliation></author><author><name sortKey="Hansen, Immo A" sort="Hansen, Immo A" uniqKey="Hansen I" first="Immo A." last="Hansen">Immo A. Hansen</name><affiliation><nlm:aff id="A49">Department of Biology, New Mexico State University, NM 88003, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Molecular Biology Program, New Mexico State University, Las Cruces, NM 88003, USA.</nlm:aff></affiliation></author><author><name sortKey="Howell, Paul I" sort="Howell, Paul I" uniqKey="Howell P" first="Paul I." last="Howell">Paul I. Howell</name><affiliation><nlm:aff id="A69">Centers for Disease Control and Prevention, 1600 Clifton Road NE MSG49, Atlanta, GA 30329, USA.</nlm:aff></affiliation></author><author><name sortKey="Kafatos, Fotis C" sort="Kafatos, Fotis C" uniqKey="Kafatos F" first="Fotis C." last="Kafatos">Fotis C. Kafatos</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation></author><author><name sortKey="Kellis, Manolis" sort="Kellis, Manolis" uniqKey="Kellis M" first="Manolis" last="Kellis">Manolis Kellis</name><affiliation><nlm:aff id="A2">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Lawson, Daniel" sort="Lawson, Daniel" uniqKey="Lawson D" first="Daniel" last="Lawson">Daniel Lawson</name><affiliation><nlm:aff id="A8">European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Louis, Christos" sort="Louis, Christos" uniqKey="Louis C" first="Christos" last="Louis">Christos Louis</name><affiliation><nlm:aff id="A41">Department of Biology, University of Crete, 700 13 Heraklion, Greece.</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, Nikolaou Plastira 100 GR-70013, Heraklion, Crete, Greece.</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Centre of Functional Genomics, University of Perugia, Perugia, Italy.</nlm:aff></affiliation></author><author><name sortKey="Luckhart, Shirley" sort="Luckhart, Shirley" uniqKey="Luckhart S" first="Shirley" last="Luckhart">Shirley Luckhart</name><affiliation><nlm:aff id="A46">Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.</nlm:aff></affiliation></author><author><name sortKey="Muskavitch, Marc A T" sort="Muskavitch, Marc A T" uniqKey="Muskavitch M" first="Marc A. T." last="Muskavitch">Marc A. T. Muskavitch</name><affiliation><nlm:aff id="A31">Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A70">Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Ribeiro, Jose M" sort="Ribeiro, Jose M" uniqKey="Ribeiro J" first="José M." last="Ribeiro">José M. Ribeiro</name><affiliation><nlm:aff id="A71">Laboratory of Malaria and Vector Research, NIAID, 12735 Twinbrook Parkway, Rockville MD 20852, USA.</nlm:aff></affiliation></author><author><name sortKey="Riehle, Michael A" sort="Riehle, Michael A" uniqKey="Riehle M" first="Michael A." last="Riehle">Michael A. Riehle</name><affiliation><nlm:aff id="A45">Department of Entomology, 1140 E. South Campus Drive, Forbes 410, University of Arizona, Tucson, AZ 85721, USA.</nlm:aff></affiliation></author><author><name sortKey="Sharakhov, Igor V" sort="Sharakhov, Igor V" uniqKey="Sharakhov I" first="Igor V." last="Sharakhov">Igor V. Sharakhov</name><affiliation><nlm:aff id="A35">Department of Entomology, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Program of Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Tu, Zhijian" sort="Tu, Zhijian" uniqKey="Tu Z" first="Zhijian" last="Tu">Zhijian Tu</name><affiliation><nlm:aff id="A32">Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Zwiebel, Laurence J" sort="Zwiebel, Laurence J" uniqKey="Zwiebel L" first="Laurence J." last="Zwiebel">Laurence J. Zwiebel</name><affiliation><nlm:aff id="A72">Departments of Biological Sciences and Pharmacology, Institutes for Chemical Biology, Genetics and Global Health, Vanderbilt University and Medical Center, Nashville, TN 37235, USA.</nlm:aff></affiliation></author><author><name sortKey="Besansky, Nora J" sort="Besansky, Nora J" uniqKey="Besansky N" first="Nora J." last="Besansky">Nora J. Besansky</name><affiliation><nlm:aff id="A42">Eck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25554792</idno><idno type="pmc">4380271</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380271</idno><idno type="RBID">PMC:4380271</idno><idno type="doi">10.1126/science.1258522</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001D23</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D23</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">“Highly evolvable malaria vectors: the genomes of 16 <italic>Anopheles</italic> mosquitoes”</title><author><name sortKey="Neafsey, Daniel E" sort="Neafsey, Daniel E" uniqKey="Neafsey D" first="Daniel E." last="Neafsey">Daniel E. Neafsey</name><affiliation><nlm:aff id="A1">Genome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Waterhouse, Robert M" sort="Waterhouse, Robert M" uniqKey="Waterhouse R" first="Robert M." last="Waterhouse">Robert M. Waterhouse</name><affiliation><nlm:aff id="A2">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Genetic Medicine and Development, University of Geneva Medical School, rue Michel-Servet 1, 1211, Geneva, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Swiss Institute of Bioinformatics, rue Michel-Servet 1, 1211 Geneva, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Abai, Mohammad R" sort="Abai, Mohammad R" uniqKey="Abai M" first="Mohammad R." last="Abai">Mohammad R. Abai</name><affiliation><nlm:aff id="A6">Department of Medical Entomology and Vector Control, School of Public Health and Institute of Health Researches, Tehran University of Medical Sciences, Tehran, Iran.</nlm:aff></affiliation></author><author><name sortKey="Aganezov, Sergey S" sort="Aganezov, Sergey S" uniqKey="Aganezov S" first="Sergey S." last="Aganezov">Sergey S. Aganezov</name><affiliation><nlm:aff id="A7">George Washington University, Department of Mathematics and Computational Biology Institute, 45085 University Drive, Ashburn, VA 20147, USA.</nlm:aff></affiliation></author><author><name sortKey="Alekseyev, Max A" sort="Alekseyev, Max A" uniqKey="Alekseyev M" first="Max A." last="Alekseyev">Max A. Alekseyev</name><affiliation><nlm:aff id="A7">George Washington University, Department of Mathematics and Computational Biology Institute, 45085 University Drive, Ashburn, VA 20147, USA.</nlm:aff></affiliation></author><author><name sortKey="Allen, James E" sort="Allen, James E" uniqKey="Allen J" first="James E." last="Allen">James E. Allen</name><affiliation><nlm:aff id="A8">European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Amon, James" sort="Amon, James" uniqKey="Amon J" first="James" last="Amon">James Amon</name><affiliation><nlm:aff id="A9">National Vector Borne Disease Control Programme, Ministry of Health, Tafea Province, Vanuatu.</nlm:aff></affiliation></author><author><name sortKey="Arca, Bruno" sort="Arca, Bruno" uniqKey="Arca B" first="Bruno" last="Arcà">Bruno Arcà</name><affiliation><nlm:aff id="A10">Department of Public Health and Infectious Diseases, Division of Parasitology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.</nlm:aff></affiliation></author><author><name sortKey="Arensburger, Peter" sort="Arensburger, Peter" uniqKey="Arensburger P" first="Peter" last="Arensburger">Peter Arensburger</name><affiliation><nlm:aff id="A11">Department of Biological Sciences, Cal Poly Pomona, 3801 West Temple Avenue, Pomona, CA 91768, USA.</nlm:aff></affiliation></author><author><name sortKey="Artemov, Gleb" sort="Artemov, Gleb" uniqKey="Artemov G" first="Gleb" last="Artemov">Gleb Artemov</name><affiliation><nlm:aff id="A12">Tomsk State University, 36 Lenina avenue, Tomsk, Russia.</nlm:aff></affiliation></author><author><name sortKey="Assour, Lauren A" sort="Assour, Lauren A" uniqKey="Assour L" first="Lauren A." last="Assour">Lauren A. Assour</name><affiliation><nlm:aff id="A13">Department of Computer Science and Engineering, Eck Institute for Global Health, 211B Cushing Hall, University of Notre Dame, Notre Dame, IN 46556, USA.</nlm:aff></affiliation></author><author><name sortKey="Basseri, Hamidreza" sort="Basseri, Hamidreza" uniqKey="Basseri H" first="Hamidreza" last="Basseri">Hamidreza Basseri</name><affiliation><nlm:aff id="A6">Department of Medical Entomology and Vector Control, School of Public Health and Institute of Health Researches, Tehran University of Medical Sciences, Tehran, Iran.</nlm:aff></affiliation></author><author><name sortKey="Berlin, Aaron" sort="Berlin, Aaron" uniqKey="Berlin A" first="Aaron" last="Berlin">Aaron Berlin</name><affiliation><nlm:aff id="A1">Genome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Birren, Bruce W" sort="Birren, Bruce W" uniqKey="Birren B" first="Bruce W." last="Birren">Bruce W. Birren</name><affiliation><nlm:aff id="A1">Genome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Blandin, Stephanie A" sort="Blandin, Stephanie A" uniqKey="Blandin S" first="Stephanie A." last="Blandin">Stephanie A. Blandin</name><affiliation><nlm:aff id="A14">Inserm, U963, Immune responses in the malaria vector A. gambiae, F-67084, Strasbourg, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A15">CNRS, UPR9022, Immune responses and development in insects, IBMC, F-67084, Strasbourg, France.</nlm:aff></affiliation></author><author><name sortKey="Brockman, Andrew I" sort="Brockman, Andrew I" uniqKey="Brockman A" first="Andrew I." last="Brockman">Andrew I. Brockman</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation></author><author><name sortKey="Burkot, Thomas R" sort="Burkot, Thomas R" uniqKey="Burkot T" first="Thomas R." last="Burkot">Thomas R. Burkot</name><affiliation><nlm:aff id="A17">Faculty of Medicine, Health and Molecular Science, Australian Institute of Tropical Health Medicine, James Cook University, Cairns 4870, Australia.</nlm:aff></affiliation></author><author><name sortKey="Burt, Austin" sort="Burt, Austin" uniqKey="Burt A" first="Austin" last="Burt">Austin Burt</name><affiliation><nlm:aff id="A18">Department of Life Sciences, Imperial College London, Silwood Park Campus, Ascot SL5 7PY, UK.</nlm:aff></affiliation></author><author><name sortKey="Chan, Clara S" sort="Chan, Clara S" uniqKey="Chan C" first="Clara S." last="Chan">Clara S. Chan</name><affiliation><nlm:aff id="A2">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Chauve, Cedric" sort="Chauve, Cedric" uniqKey="Chauve C" first="Cedric" last="Chauve">Cedric Chauve</name><affiliation><nlm:aff id="A19">Department of Mathematics, Simon Fraser University, 8888 University Drive, Burnaby BC, V5A1S6, Canada.</nlm:aff></affiliation></author><author><name sortKey="Chiu, Joanna C" sort="Chiu, Joanna C" uniqKey="Chiu J" first="Joanna C." last="Chiu">Joanna C. Chiu</name><affiliation><nlm:aff id="A20">Department of Entomology and Nematology, One Shields Avenue, UC Davis, Davis, CA 95616, USA.</nlm:aff></affiliation></author><author><name sortKey="Christensen, Mikkel" sort="Christensen, Mikkel" uniqKey="Christensen M" first="Mikkel" last="Christensen">Mikkel Christensen</name><affiliation><nlm:aff id="A8">European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Costantini, Carlo" sort="Costantini, Carlo" uniqKey="Costantini C" first="Carlo" last="Costantini">Carlo Costantini</name><affiliation><nlm:aff id="A21">Institut de Recherche pour le Développement, UMR MIVEGEC, 911, Avenue Agropolis, BP 64501 Montpellier, France.</nlm:aff></affiliation></author><author><name sortKey="Davidson, Victoria L M" sort="Davidson, Victoria L M" uniqKey="Davidson V" first="Victoria L. M." last="Davidson">Victoria L. M. Davidson</name><affiliation><nlm:aff id="A22">Division of Biology, Kansas State University, 271 Chalmers Hall, Manhattan, KS 66506, USA.</nlm:aff></affiliation></author><author><name sortKey="Deligianni, Elena" sort="Deligianni, Elena" uniqKey="Deligianni E" first="Elena" last="Deligianni">Elena Deligianni</name><affiliation><nlm:aff id="A23">Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, Nikolaou Plastira 100 GR-70013, Heraklion, Crete, Greece.</nlm:aff></affiliation></author><author><name sortKey="Dottorini, Tania" sort="Dottorini, Tania" uniqKey="Dottorini T" first="Tania" last="Dottorini">Tania Dottorini</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation></author><author><name sortKey="Dritsou, Vicky" sort="Dritsou, Vicky" uniqKey="Dritsou V" first="Vicky" last="Dritsou">Vicky Dritsou</name><affiliation><nlm:aff id="A24">Centre of Functional Genomics, University of Perugia, Perugia, Italy.</nlm:aff></affiliation></author><author><name sortKey="Gabriel, Stacey B" sort="Gabriel, Stacey B" uniqKey="Gabriel S" first="Stacey B." last="Gabriel">Stacey B. Gabriel</name><affiliation><nlm:aff id="A25">Genomics Platform, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Guelbeogo, Wamdaogo M" sort="Guelbeogo, Wamdaogo M" uniqKey="Guelbeogo W" first="Wamdaogo M." last="Guelbeogo">Wamdaogo M. Guelbeogo</name><affiliation><nlm:aff id="A26">Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou 01 BP 2208, Burkina Faso.</nlm:aff></affiliation></author><author><name sortKey="Hall, Andrew B" sort="Hall, Andrew B" uniqKey="Hall A" first="Andrew B." last="Hall">Andrew B. Hall</name><affiliation><nlm:aff id="A27">Program of Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Han, Mira V" sort="Han, Mira V" uniqKey="Han M" first="Mira V." last="Han">Mira V. Han</name><affiliation><nlm:aff id="A28">School of Life Sciences, University of Nevada, Las Vegas, NV 89154, USA.</nlm:aff></affiliation></author><author><name sortKey="Hlaing, Thaung" sort="Hlaing, Thaung" uniqKey="Hlaing T" first="Thaung" last="Hlaing">Thaung Hlaing</name><affiliation><nlm:aff id="A29">Department of Medical Research, No. 5, Ziwaka Road, Dagon Township, Yangon 11191, Myanmar.</nlm:aff></affiliation></author><author><name sortKey="Hughes, Daniel S T" sort="Hughes, Daniel S T" uniqKey="Hughes D" first="Daniel S. T." last="Hughes">Daniel S. T. Hughes</name><affiliation><nlm:aff id="A8">European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.</nlm:aff></affiliation></author><author><name sortKey="Jenkins, Adam M" sort="Jenkins, Adam M" uniqKey="Jenkins A" first="Adam M." last="Jenkins">Adam M. Jenkins</name><affiliation><nlm:aff id="A31">Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA.</nlm:aff></affiliation></author><author><name sortKey="Jiang, Xiaofang" sort="Jiang, Xiaofang" uniqKey="Jiang X" first="Xiaofang" last="Jiang">Xiaofang Jiang</name><affiliation><nlm:aff id="A32">Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Program of Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Jungreis, Irwin" sort="Jungreis, Irwin" uniqKey="Jungreis I" first="Irwin" last="Jungreis">Irwin Jungreis</name><affiliation><nlm:aff id="A2">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Kakani, Evdoxia G" sort="Kakani, Evdoxia G" uniqKey="Kakani E" first="Evdoxia G." last="Kakani">Evdoxia G. Kakani</name><affiliation><nlm:aff id="A33">Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02115, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy.</nlm:aff></affiliation></author><author><name sortKey="Kamali, Maryam" sort="Kamali, Maryam" uniqKey="Kamali M" first="Maryam" last="Kamali">Maryam Kamali</name><affiliation><nlm:aff id="A35">Department of Entomology, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Kemppainen, Petri" sort="Kemppainen, Petri" uniqKey="Kemppainen P" first="Petri" last="Kemppainen">Petri Kemppainen</name><affiliation><nlm:aff id="A36">Computational Evolutionary Biology Group, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.</nlm:aff></affiliation></author><author><name sortKey="Kennedy, Ryan C" sort="Kennedy, Ryan C" uniqKey="Kennedy R" first="Ryan C." last="Kennedy">Ryan C. Kennedy</name><affiliation><nlm:aff id="A37">Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143, USA.</nlm:aff></affiliation></author><author><name sortKey="Kirmitzoglou, Ioannis K" sort="Kirmitzoglou, Ioannis K" uniqKey="Kirmitzoglou I" first="Ioannis K." last="Kirmitzoglou">Ioannis K. Kirmitzoglou</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Bioinformatics Research Laboratory, Department of Biological Sciences, New Campus, University of Cyprus, CY 1678, Nicosia, Cyprus.</nlm:aff></affiliation></author><author><name sortKey="Koekemoer, Lizette L" sort="Koekemoer, Lizette L" uniqKey="Koekemoer L" first="Lizette L." last="Koekemoer">Lizette L. Koekemoer</name><affiliation><nlm:aff id="A39">Wits Research Institute for Malaria, Faculty of Health Sciences, and Vector Control Reference Unit, National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham 2131, Johannesburg, South Africa.</nlm:aff></affiliation></author><author><name sortKey="Laban, Njoroge" sort="Laban, Njoroge" uniqKey="Laban N" first="Njoroge" last="Laban">Njoroge Laban</name><affiliation><nlm:aff id="A40">National Museums of Kenya, P.O. Box 40658-00100, Nairobi, Kenya.</nlm:aff></affiliation></author><author><name sortKey="Langridge, Nicholas" sort="Langridge, Nicholas" uniqKey="Langridge N" first="Nicholas" last="Langridge">Nicholas Langridge</name><affiliation><nlm:aff id="A8">European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Lawniczak, Mara K N" sort="Lawniczak, Mara K N" uniqKey="Lawniczak M" first="Mara K. N." last="Lawniczak">Mara K. N. Lawniczak</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation></author><author><name sortKey="Lirakis, Manolis" sort="Lirakis, Manolis" uniqKey="Lirakis M" first="Manolis" last="Lirakis">Manolis Lirakis</name><affiliation><nlm:aff id="A41">Department of Biology, University of Crete, 700 13 Heraklion, Greece.</nlm:aff></affiliation></author><author><name sortKey="Lobo, Neil F" sort="Lobo, Neil F" uniqKey="Lobo N" first="Neil F." last="Lobo">Neil F. Lobo</name><affiliation><nlm:aff id="A42">Eck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA.</nlm:aff></affiliation></author><author><name sortKey="Lowy, Ernesto" sort="Lowy, Ernesto" uniqKey="Lowy E" first="Ernesto" last="Lowy">Ernesto Lowy</name><affiliation><nlm:aff id="A8">European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Maccallum, Robert M" sort="Maccallum, Robert M" uniqKey="Maccallum R" first="Robert M." last="Maccallum">Robert M. Maccallum</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation></author><author><name sortKey="Mao, Chunhong" sort="Mao, Chunhong" uniqKey="Mao C" first="Chunhong" last="Mao">Chunhong Mao</name><affiliation><nlm:aff id="A43">Virginia Bioinformatics Institute, 1015 Life Science Circle, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Maslen, Gareth" sort="Maslen, Gareth" uniqKey="Maslen G" first="Gareth" last="Maslen">Gareth Maslen</name><affiliation><nlm:aff id="A8">European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Mbogo, Charles" sort="Mbogo, Charles" uniqKey="Mbogo C" first="Charles" last="Mbogo">Charles Mbogo</name><affiliation><nlm:aff id="A44">KEMRI-Wellcome Trust Research Programme, CGMRC, PO Box 230-80108, Kilifi, Kenya.</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Jenny" sort="Mccarthy, Jenny" uniqKey="Mccarthy J" first="Jenny" last="Mccarthy">Jenny Mccarthy</name><affiliation><nlm:aff id="A11">Department of Biological Sciences, Cal Poly Pomona, 3801 West Temple Avenue, Pomona, CA 91768, USA.</nlm:aff></affiliation></author><author><name sortKey="Michel, Kristin" sort="Michel, Kristin" uniqKey="Michel K" first="Kristin" last="Michel">Kristin Michel</name><affiliation><nlm:aff id="A22">Division of Biology, Kansas State University, 271 Chalmers Hall, Manhattan, KS 66506, USA.</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Sara N" sort="Mitchell, Sara N" uniqKey="Mitchell S" first="Sara N." last="Mitchell">Sara N. Mitchell</name><affiliation><nlm:aff id="A33">Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02115, USA.</nlm:aff></affiliation></author><author><name sortKey="Moore, Wendy" sort="Moore, Wendy" uniqKey="Moore W" first="Wendy" last="Moore">Wendy Moore</name><affiliation><nlm:aff id="A45">Department of Entomology, 1140 E. South Campus Drive, Forbes 410, University of Arizona, Tucson, AZ 85721, USA.</nlm:aff></affiliation></author><author><name sortKey="Murphy, Katherine A" sort="Murphy, Katherine A" uniqKey="Murphy K" first="Katherine A." last="Murphy">Katherine A. Murphy</name><affiliation><nlm:aff id="A20">Department of Entomology and Nematology, One Shields Avenue, UC Davis, Davis, CA 95616, USA.</nlm:aff></affiliation></author><author><name sortKey="Naumenko, Anastasia N" sort="Naumenko, Anastasia N" uniqKey="Naumenko A" first="Anastasia N." last="Naumenko">Anastasia N. Naumenko</name><affiliation><nlm:aff id="A35">Department of Entomology, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Nolan, Tony" sort="Nolan, Tony" uniqKey="Nolan T" first="Tony" last="Nolan">Tony Nolan</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation></author><author><name sortKey="Novoa, Eva M" sort="Novoa, Eva M" uniqKey="Novoa E" first="Eva M." last="Novoa">Eva M. Novoa</name><affiliation><nlm:aff id="A2">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="O Loughlin, Samantha" sort="O Loughlin, Samantha" uniqKey="O Loughlin S" first="Samantha" last="O'Loughlin">Samantha O'Loughlin</name><affiliation><nlm:aff id="A18">Department of Life Sciences, Imperial College London, Silwood Park Campus, Ascot SL5 7PY, UK.</nlm:aff></affiliation></author><author><name sortKey="Oringanje, Chioma" sort="Oringanje, Chioma" uniqKey="Oringanje C" first="Chioma" last="Oringanje">Chioma Oringanje</name><affiliation><nlm:aff id="A45">Department of Entomology, 1140 E. South Campus Drive, Forbes 410, University of Arizona, Tucson, AZ 85721, USA.</nlm:aff></affiliation></author><author><name sortKey="Oshaghi, Mohammad A" sort="Oshaghi, Mohammad A" uniqKey="Oshaghi M" first="Mohammad A." last="Oshaghi">Mohammad A. Oshaghi</name><affiliation><nlm:aff id="A6">Department of Medical Entomology and Vector Control, School of Public Health and Institute of Health Researches, Tehran University of Medical Sciences, Tehran, Iran.</nlm:aff></affiliation></author><author><name sortKey="Pakpour, Nazzy" sort="Pakpour, Nazzy" uniqKey="Pakpour N" first="Nazzy" last="Pakpour">Nazzy Pakpour</name><affiliation><nlm:aff id="A46">Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.</nlm:aff></affiliation></author><author><name sortKey="Papathanos, Philippos A" sort="Papathanos, Philippos A" uniqKey="Papathanos P" first="Philippos A." last="Papathanos">Philippos A. Papathanos</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Centre of Functional Genomics, University of Perugia, Perugia, Italy.</nlm:aff></affiliation></author><author><name sortKey="Peery, Ashley N" sort="Peery, Ashley N" uniqKey="Peery A" first="Ashley N." last="Peery">Ashley N. Peery</name><affiliation><nlm:aff id="A35">Department of Entomology, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Povelones, Michael" sort="Povelones, Michael" uniqKey="Povelones M" first="Michael" last="Povelones">Michael Povelones</name><affiliation><nlm:aff id="A47">Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA.</nlm:aff></affiliation></author><author><name sortKey="Prakash, Anil" sort="Prakash, Anil" uniqKey="Prakash A" first="Anil" last="Prakash">Anil Prakash</name><affiliation><nlm:aff id="A48">Regional Medical Research Centre NE, Indian Council of Medical Research, PO Box 105, Dibrugarh-786 001, Assam, India.</nlm:aff></affiliation></author><author><name sortKey="Price, David P" sort="Price, David P" uniqKey="Price D" first="David P." last="Price">David P. Price</name><affiliation><nlm:aff id="A49">Department of Biology, New Mexico State University, NM 88003, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Molecular Biology Program, New Mexico State University, Las Cruces, NM 88003, USA.</nlm:aff></affiliation></author><author><name sortKey="Rajaraman, Ashok" sort="Rajaraman, Ashok" uniqKey="Rajaraman A" first="Ashok" last="Rajaraman">Ashok Rajaraman</name><affiliation><nlm:aff id="A19">Department of Mathematics, Simon Fraser University, 8888 University Drive, Burnaby BC, V5A1S6, Canada.</nlm:aff></affiliation></author><author><name sortKey="Reimer, Lisa J" sort="Reimer, Lisa J" uniqKey="Reimer L" first="Lisa J." last="Reimer">Lisa J. Reimer</name><affiliation><nlm:aff id="A51">Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L35QA, UK.</nlm:aff></affiliation></author><author><name sortKey="Rinker, David C" sort="Rinker, David C" uniqKey="Rinker D" first="David C." last="Rinker">David C. Rinker</name><affiliation><nlm:aff id="A52">Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37235, USA.</nlm:aff></affiliation></author><author><name sortKey="Rokas, Antonis" sort="Rokas, Antonis" uniqKey="Rokas A" first="Antonis" last="Rokas">Antonis Rokas</name><affiliation><nlm:aff id="A52">Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37235, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.</nlm:aff></affiliation></author><author><name sortKey="Russell, Tanya L" sort="Russell, Tanya L" uniqKey="Russell T" first="Tanya L." last="Russell">Tanya L. Russell</name><affiliation><nlm:aff id="A17">Faculty of Medicine, Health and Molecular Science, Australian Institute of Tropical Health Medicine, James Cook University, Cairns 4870, Australia.</nlm:aff></affiliation></author><author><name sortKey="Sagnon, N Fale" sort="Sagnon, N Fale" uniqKey="Sagnon N" first="N'Fale" last="Sagnon">N'Fale Sagnon</name><affiliation><nlm:aff id="A26">Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou 01 BP 2208, Burkina Faso.</nlm:aff></affiliation></author><author><name sortKey="Sharakhova, Maria V" sort="Sharakhova, Maria V" uniqKey="Sharakhova M" first="Maria V." last="Sharakhova">Maria V. Sharakhova</name><affiliation><nlm:aff id="A35">Department of Entomology, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Shea, Terrance" sort="Shea, Terrance" uniqKey="Shea T" first="Terrance" last="Shea">Terrance Shea</name><affiliation><nlm:aff id="A1">Genome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Simao, Felipe A" sort="Simao, Felipe A" uniqKey="Simao F" first="Felipe A." last="Simão">Felipe A. Simão</name><affiliation><nlm:aff id="A4">Department of Genetic Medicine and Development, University of Geneva Medical School, rue Michel-Servet 1, 1211, Geneva, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Swiss Institute of Bioinformatics, rue Michel-Servet 1, 1211 Geneva, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Simard, Frederic" sort="Simard, Frederic" uniqKey="Simard F" first="Frederic" last="Simard">Frederic Simard</name><affiliation><nlm:aff id="A21">Institut de Recherche pour le Développement, UMR MIVEGEC, 911, Avenue Agropolis, BP 64501 Montpellier, France.</nlm:aff></affiliation></author><author><name sortKey="Slotman, Michel A" sort="Slotman, Michel A" uniqKey="Slotman M" first="Michel A." last="Slotman">Michel A. Slotman</name><affiliation><nlm:aff id="A54">Department of Entomology, Texas A&M University, College Station, TX 77807, USA.</nlm:aff></affiliation></author><author><name sortKey="Somboon, Pradya" sort="Somboon, Pradya" uniqKey="Somboon P" first="Pradya" last="Somboon">Pradya Somboon</name><affiliation><nlm:aff id="A55">Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.</nlm:aff></affiliation></author><author><name sortKey="Stegniy, Vladimir" sort="Stegniy, Vladimir" uniqKey="Stegniy V" first="Vladimir" last="Stegniy">Vladimir Stegniy</name><affiliation><nlm:aff id="A12">Tomsk State University, 36 Lenina avenue, Tomsk, Russia.</nlm:aff></affiliation></author><author><name sortKey="Struchiner, Claudio J" sort="Struchiner, Claudio J" uniqKey="Struchiner C" first="Claudio J." last="Struchiner">Claudio J. Struchiner</name><affiliation><nlm:aff id="A56">Fundação Oswaldo Cruz, Av Brasil 4365, RJ Brazil.</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Instituto de Medicina Social, UERJ, Rio de Janeiro, Brazil.</nlm:aff></affiliation></author><author><name sortKey="Thomas, Gregg W C" sort="Thomas, Gregg W C" uniqKey="Thomas G" first="Gregg W. C." last="Thomas">Gregg W. C. Thomas</name><affiliation><nlm:aff id="A58">School of Informatics and Computing, Indiana University, Bloomington, IN 47405, USA.</nlm:aff></affiliation></author><author><name sortKey="Tojo, Marta" sort="Tojo, Marta" uniqKey="Tojo M" first="Marta" last="Tojo">Marta Tojo</name><affiliation><nlm:aff id="A59">Department of Physiology, School of Medicine, CIMUS, Instituto de Investigaciones, Sanitarias, University of Santiago de Compostela, Spain.</nlm:aff></affiliation></author><author><name sortKey="Topalis, Pantelis" sort="Topalis, Pantelis" uniqKey="Topalis P" first="Pantelis" last="Topalis">Pantelis Topalis</name><affiliation><nlm:aff id="A23">Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, Nikolaou Plastira 100 GR-70013, Heraklion, Crete, Greece.</nlm:aff></affiliation></author><author><name sortKey="Tubio, Jose M C" sort="Tubio, Jose M C" uniqKey="Tubio J" first="José M. C." last="Tubio">José M. C. Tubio</name><affiliation><nlm:aff id="A60">Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK.</nlm:aff></affiliation></author><author><name sortKey="Unger, Maria F" sort="Unger, Maria F" uniqKey="Unger M" first="Maria F." last="Unger">Maria F. Unger</name><affiliation><nlm:aff id="A42">Eck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA.</nlm:aff></affiliation></author><author><name sortKey="Vontas, John" sort="Vontas, John" uniqKey="Vontas J" first="John" last="Vontas">John Vontas</name><affiliation><nlm:aff id="A41">Department of Biology, University of Crete, 700 13 Heraklion, Greece.</nlm:aff></affiliation></author><author><name sortKey="Walton, Catherine" sort="Walton, Catherine" uniqKey="Walton C" first="Catherine" last="Walton">Catherine Walton</name><affiliation><nlm:aff id="A36">Computational Evolutionary Biology Group, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.</nlm:aff></affiliation></author><author><name sortKey="Wilding, Craig S" sort="Wilding, Craig S" uniqKey="Wilding C" first="Craig S." last="Wilding">Craig S. Wilding</name><affiliation><nlm:aff id="A61">School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, L3 3AF, UK.</nlm:aff></affiliation></author><author><name sortKey="Willis, Judith H" sort="Willis, Judith H" uniqKey="Willis J" first="Judith H." last="Willis">Judith H. Willis</name><affiliation><nlm:aff id="A62">Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA.</nlm:aff></affiliation></author><author><name sortKey="Wu, Yi Chieh" sort="Wu, Yi Chieh" uniqKey="Wu Y" first="Yi-Chieh" last="Wu">Yi-Chieh Wu</name><affiliation><nlm:aff id="A2">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A63">Department of Computer Science, Harvey Mudd College, Claremont, CA 91711, USA.</nlm:aff></affiliation></author><author><name sortKey="Yan, Guiyun" sort="Yan, Guiyun" uniqKey="Yan G" first="Guiyun" last="Yan">Guiyun Yan</name><affiliation><nlm:aff id="A64">Program in Public Health, College of Health Sciences, University of California, Irvine, Hewitt Hall, Irvine, CA 92697, USA.</nlm:aff></affiliation></author><author><name sortKey="Zdobnov, Evgeny M" sort="Zdobnov, Evgeny M" uniqKey="Zdobnov E" first="Evgeny M." last="Zdobnov">Evgeny M. Zdobnov</name><affiliation><nlm:aff id="A4">Department of Genetic Medicine and Development, University of Geneva Medical School, rue Michel-Servet 1, 1211, Geneva, Switzerland.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Swiss Institute of Bioinformatics, rue Michel-Servet 1, 1211 Geneva, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Zhou, Xiaofan" sort="Zhou, Xiaofan" uniqKey="Zhou X" first="Xiaofan" last="Zhou">Xiaofan Zhou</name><affiliation><nlm:aff id="A53">Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.</nlm:aff></affiliation></author><author><name sortKey="Catteruccia, Flaminia" sort="Catteruccia, Flaminia" uniqKey="Catteruccia F" first="Flaminia" last="Catteruccia">Flaminia Catteruccia</name><affiliation><nlm:aff id="A33">Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02115, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy.</nlm:aff></affiliation></author><author><name sortKey="Christophides, George K" sort="Christophides, George K" uniqKey="Christophides G" first="George K." last="Christophides">George K. Christophides</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation></author><author><name sortKey="Collins, Frank H" sort="Collins, Frank H" uniqKey="Collins F" first="Frank H." last="Collins">Frank H. Collins</name><affiliation><nlm:aff id="A42">Eck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA.</nlm:aff></affiliation></author><author><name sortKey="Cornman, Robert S" sort="Cornman, Robert S" uniqKey="Cornman R" first="Robert S." last="Cornman">Robert S. Cornman</name><affiliation><nlm:aff id="A62">Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA.</nlm:aff></affiliation></author><author><name sortKey="Crisanti, Andrea" sort="Crisanti, Andrea" uniqKey="Crisanti A" first="Andrea" last="Crisanti">Andrea Crisanti</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Centre of Functional Genomics, University of Perugia, Perugia, Italy.</nlm:aff></affiliation></author><author><name sortKey="Donnelly, Martin J" sort="Donnelly, Martin J" uniqKey="Donnelly M" first="Martin J." last="Donnelly">Martin J. Donnelly</name><affiliation><nlm:aff id="A51">Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L35QA, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Malaria Programme, Wellcome Trust Sanger Institute, Cambridge, CB10 1SJ, UK.</nlm:aff></affiliation></author><author><name sortKey="Emrich, Scott J" sort="Emrich, Scott J" uniqKey="Emrich S" first="Scott J." last="Emrich">Scott J. Emrich</name><affiliation><nlm:aff id="A13">Department of Computer Science and Engineering, Eck Institute for Global Health, 211B Cushing Hall, University of Notre Dame, Notre Dame, IN 46556, USA.</nlm:aff></affiliation></author><author><name sortKey="Fontaine, Michael C" sort="Fontaine, Michael C" uniqKey="Fontaine M" first="Michael C." last="Fontaine">Michael C. Fontaine</name><affiliation><nlm:aff id="A42">Eck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Centre of Evolutionary and Ecological Studies (CEES-MarECon group), University of Groningen, Nijenborgh 7, NL-9747 AG Groningen, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Gelbart, William" sort="Gelbart, William" uniqKey="Gelbart W" first="William" last="Gelbart">William Gelbart</name><affiliation><nlm:aff id="A67">Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave, Cambridge, MA 02138, USA.</nlm:aff></affiliation></author><author><name sortKey="Hahn, Matthew W" sort="Hahn, Matthew W" uniqKey="Hahn M" first="Matthew W." last="Hahn">Matthew W. Hahn</name><affiliation><nlm:aff id="A68">Department of Biology, Indiana University, Bloomington, IN 47405, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A58">School of Informatics and Computing, Indiana University, Bloomington, IN 47405, USA.</nlm:aff></affiliation></author><author><name sortKey="Hansen, Immo A" sort="Hansen, Immo A" uniqKey="Hansen I" first="Immo A." last="Hansen">Immo A. Hansen</name><affiliation><nlm:aff id="A49">Department of Biology, New Mexico State University, NM 88003, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A50">Molecular Biology Program, New Mexico State University, Las Cruces, NM 88003, USA.</nlm:aff></affiliation></author><author><name sortKey="Howell, Paul I" sort="Howell, Paul I" uniqKey="Howell P" first="Paul I." last="Howell">Paul I. Howell</name><affiliation><nlm:aff id="A69">Centers for Disease Control and Prevention, 1600 Clifton Road NE MSG49, Atlanta, GA 30329, USA.</nlm:aff></affiliation></author><author><name sortKey="Kafatos, Fotis C" sort="Kafatos, Fotis C" uniqKey="Kafatos F" first="Fotis C." last="Kafatos">Fotis C. Kafatos</name><affiliation><nlm:aff id="A16">Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:aff></affiliation></author><author><name sortKey="Kellis, Manolis" sort="Kellis, Manolis" uniqKey="Kellis M" first="Manolis" last="Kellis">Manolis Kellis</name><affiliation><nlm:aff id="A2">Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Lawson, Daniel" sort="Lawson, Daniel" uniqKey="Lawson D" first="Daniel" last="Lawson">Daniel Lawson</name><affiliation><nlm:aff id="A8">European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</nlm:aff></affiliation></author><author><name sortKey="Louis, Christos" sort="Louis, Christos" uniqKey="Louis C" first="Christos" last="Louis">Christos Louis</name><affiliation><nlm:aff id="A41">Department of Biology, University of Crete, 700 13 Heraklion, Greece.</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, Nikolaou Plastira 100 GR-70013, Heraklion, Crete, Greece.</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Centre of Functional Genomics, University of Perugia, Perugia, Italy.</nlm:aff></affiliation></author><author><name sortKey="Luckhart, Shirley" sort="Luckhart, Shirley" uniqKey="Luckhart S" first="Shirley" last="Luckhart">Shirley Luckhart</name><affiliation><nlm:aff id="A46">Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.</nlm:aff></affiliation></author><author><name sortKey="Muskavitch, Marc A T" sort="Muskavitch, Marc A T" uniqKey="Muskavitch M" first="Marc A. T." last="Muskavitch">Marc A. T. Muskavitch</name><affiliation><nlm:aff id="A31">Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A70">Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA.</nlm:aff></affiliation></author><author><name sortKey="Ribeiro, Jose M" sort="Ribeiro, Jose M" uniqKey="Ribeiro J" first="José M." last="Ribeiro">José M. Ribeiro</name><affiliation><nlm:aff id="A71">Laboratory of Malaria and Vector Research, NIAID, 12735 Twinbrook Parkway, Rockville MD 20852, USA.</nlm:aff></affiliation></author><author><name sortKey="Riehle, Michael A" sort="Riehle, Michael A" uniqKey="Riehle M" first="Michael A." last="Riehle">Michael A. Riehle</name><affiliation><nlm:aff id="A45">Department of Entomology, 1140 E. South Campus Drive, Forbes 410, University of Arizona, Tucson, AZ 85721, USA.</nlm:aff></affiliation></author><author><name sortKey="Sharakhov, Igor V" sort="Sharakhov, Igor V" uniqKey="Sharakhov I" first="Igor V." last="Sharakhov">Igor V. Sharakhov</name><affiliation><nlm:aff id="A35">Department of Entomology, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Program of Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Tu, Zhijian" sort="Tu, Zhijian" uniqKey="Tu Z" first="Zhijian" last="Tu">Zhijian Tu</name><affiliation><nlm:aff id="A32">Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA.</nlm:aff></affiliation></author><author><name sortKey="Zwiebel, Laurence J" sort="Zwiebel, Laurence J" uniqKey="Zwiebel L" first="Laurence J." last="Zwiebel">Laurence J. Zwiebel</name><affiliation><nlm:aff id="A72">Departments of Biological Sciences and Pharmacology, Institutes for Chemical Biology, Genetics and Global Health, Vanderbilt University and Medical Center, Nashville, TN 37235, USA.</nlm:aff></affiliation></author><author><name sortKey="Besansky, Nora J" sort="Besansky, Nora J" uniqKey="Besansky N" first="Nora J." last="Besansky">Nora J. Besansky</name><affiliation><nlm:aff id="A42">Eck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA.</nlm:aff></affiliation></author></analytic><series><title level="j">Science (New York, N.Y.)</title><idno type="ISSN">0036-8075</idno><idno type="eISSN">1095-9203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Variation in vectorial capacity for human malaria among <italic>Anopheles</italic> mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to <italic>Drosophila</italic>. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover, but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0404511</journal-id><journal-id journal-id-type="pubmed-jr-id">7473</journal-id><journal-id journal-id-type="nlm-ta">Science</journal-id><journal-id journal-id-type="iso-abbrev">Science</journal-id><journal-title-group><journal-title>Science (New York, N.Y.)</journal-title></journal-title-group><issn pub-type="ppub">0036-8075</issn><issn pub-type="epub">1095-9203</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25554792</article-id><article-id pub-id-type="pmc">4380271</article-id><article-id pub-id-type="doi">10.1126/science.1258522</article-id><article-id pub-id-type="manuscript">NIHMS674316</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>“Highly evolvable malaria vectors: the genomes of 16 <italic>Anopheles</italic> mosquitoes”</article-title></title-group><contrib-group><contrib 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contrib-type="author"><name><surname>Tu</surname><given-names>Zhijian</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Zwiebel</surname><given-names>Laurence J.</given-names></name><xref ref-type="aff" rid="A72">72</xref></contrib><contrib contrib-type="author"><name><surname>Besansky</surname><given-names>Nora J.</given-names></name><xref ref-type="aff" rid="A42">42</xref><xref ref-type="corresp" rid="cor1">†</xref></contrib></contrib-group><aff id="A1"><label>1</label>Genome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.</aff><aff id="A2"><label>2</label>Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA.</aff><aff id="A3"><label>3</label>The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.</aff><aff id="A4"><label>4</label>Department of Genetic Medicine and Development, University of Geneva Medical School, rue Michel-Servet 1, 1211, Geneva, Switzerland.</aff><aff id="A5"><label>5</label>Swiss Institute of Bioinformatics, rue Michel-Servet 1, 1211 Geneva, Switzerland.</aff><aff id="A6"><label>6</label>Department of Medical Entomology and Vector Control, School of Public Health and Institute of Health Researches, Tehran University of Medical Sciences, Tehran, Iran.</aff><aff id="A7"><label>7</label>George Washington University, Department of Mathematics and Computational Biology Institute, 45085 University Drive, Ashburn, VA 20147, USA.</aff><aff id="A8"><label>8</label>European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.</aff><aff id="A9"><label>9</label>National Vector Borne Disease Control Programme, Ministry of Health, Tafea Province, Vanuatu.</aff><aff id="A10"><label>10</label>Department of Public Health and Infectious Diseases, Division of Parasitology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.</aff><aff id="A11"><label>11</label>Department of Biological Sciences, Cal Poly Pomona, 3801 West Temple Avenue, Pomona, CA 91768, USA.</aff><aff id="A12"><label>12</label>Tomsk State University, 36 Lenina avenue, Tomsk, Russia.</aff><aff id="A13"><label>13</label>Department of Computer Science and Engineering, Eck Institute for Global Health, 211B Cushing Hall, University of Notre Dame, Notre Dame, IN 46556, USA.</aff><aff id="A14"><label>14</label>Inserm, U963, Immune responses in the malaria vector A. gambiae, F-67084, Strasbourg, France.</aff><aff id="A15"><label>15</label>CNRS, UPR9022, Immune responses and development in insects, IBMC, F-67084, Strasbourg, France.</aff><aff id="A16"><label>16</label>Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</aff><aff id="A17"><label>17</label>Faculty of Medicine, Health and Molecular Science, Australian Institute of Tropical Health Medicine, James Cook University, Cairns 4870, Australia.</aff><aff id="A18"><label>18</label>Department of Life Sciences, Imperial College London, Silwood Park Campus, Ascot SL5 7PY, UK.</aff><aff id="A19"><label>19</label>Department of Mathematics, Simon Fraser University, 8888 University Drive, Burnaby BC, V5A1S6, Canada.</aff><aff id="A20"><label>20</label>Department of Entomology and Nematology, One Shields Avenue, UC Davis, Davis, CA 95616, USA.</aff><aff id="A21"><label>21</label>Institut de Recherche pour le Développement, UMR MIVEGEC, 911, Avenue Agropolis, BP 64501 Montpellier, France.</aff><aff id="A22"><label>22</label>Division of Biology, Kansas State University, 271 Chalmers Hall, Manhattan, KS 66506, USA.</aff><aff id="A23"><label>23</label>Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, Nikolaou Plastira 100 GR-70013, Heraklion, Crete, Greece.</aff><aff id="A24"><label>24</label>Centre of Functional Genomics, University of Perugia, Perugia, Italy.</aff><aff id="A25"><label>25</label>Genomics Platform, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.</aff><aff id="A26"><label>26</label>Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou 01 BP 2208, Burkina Faso.</aff><aff id="A27"><label>27</label>Program of Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, VA 24061, USA.</aff><aff id="A28"><label>28</label>School of Life Sciences, University of Nevada, Las Vegas, NV 89154, USA.</aff><aff id="A29"><label>29</label>Department of Medical Research, No. 5, Ziwaka Road, Dagon Township, Yangon 11191, Myanmar.</aff><aff id="A30"><label>30</label>Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.</aff><aff id="A31"><label>31</label>Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA.</aff><aff id="A32"><label>32</label>Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA.</aff><aff id="A33"><label>33</label>Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02115, USA.</aff><aff id="A34"><label>34</label>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy.</aff><aff id="A35"><label>35</label>Department of Entomology, Virginia Tech, Blacksburg, VA 24061, USA.</aff><aff id="A36"><label>36</label>Computational Evolutionary Biology Group, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.</aff><aff id="A37"><label>37</label>Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143, USA.</aff><aff id="A38"><label>38</label>Bioinformatics Research Laboratory, Department of Biological Sciences, New Campus, University of Cyprus, CY 1678, Nicosia, Cyprus.</aff><aff id="A39"><label>39</label>Wits Research Institute for Malaria, Faculty of Health Sciences, and Vector Control Reference Unit, National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham 2131, Johannesburg, South Africa.</aff><aff id="A40"><label>40</label>National Museums of Kenya, P.O. Box 40658-00100, Nairobi, Kenya.</aff><aff id="A41"><label>41</label>Department of Biology, University of Crete, 700 13 Heraklion, Greece.</aff><aff id="A42"><label>42</label>Eck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA.</aff><aff id="A43"><label>43</label>Virginia Bioinformatics Institute, 1015 Life Science Circle, Virginia Tech, Blacksburg, VA 24061, USA.</aff><aff id="A44"><label>44</label>KEMRI-Wellcome Trust Research Programme, CGMRC, PO Box 230-80108, Kilifi, Kenya.</aff><aff id="A45"><label>45</label>Department of Entomology, 1140 E. South Campus Drive, Forbes 410, University of Arizona, Tucson, AZ 85721, USA.</aff><aff id="A46"><label>46</label>Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.</aff><aff id="A47"><label>47</label>Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA.</aff><aff id="A48"><label>48</label>Regional Medical Research Centre NE, Indian Council of Medical Research, PO Box 105, Dibrugarh-786 001, Assam, India.</aff><aff id="A49"><label>49</label>Department of Biology, New Mexico State University, NM 88003, USA.</aff><aff id="A50"><label>50</label>Molecular Biology Program, New Mexico State University, Las Cruces, NM 88003, USA.</aff><aff id="A51"><label>51</label>Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L35QA, UK.</aff><aff id="A52"><label>52</label>Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37235, USA.</aff><aff id="A53"><label>53</label>Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.</aff><aff id="A54"><label>54</label>Department of Entomology, Texas A&M University, College Station, TX 77807, USA.</aff><aff id="A55"><label>55</label>Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.</aff><aff id="A56"><label>56</label>Fundação Oswaldo Cruz, Av Brasil 4365, RJ Brazil.</aff><aff id="A57"><label>57</label>Instituto de Medicina Social, UERJ, Rio de Janeiro, Brazil.</aff><aff id="A58"><label>58</label>School of Informatics and Computing, Indiana University, Bloomington, IN 47405, USA.</aff><aff id="A59"><label>59</label>Department of Physiology, School of Medicine, CIMUS, Instituto de Investigaciones, Sanitarias, University of Santiago de Compostela, Spain.</aff><aff id="A60"><label>60</label>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK.</aff><aff id="A61"><label>61</label>School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, L3 3AF, UK.</aff><aff id="A62"><label>62</label>Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA.</aff><aff id="A63"><label>63</label>Department of Computer Science, Harvey Mudd College, Claremont, CA 91711, USA.</aff><aff id="A64"><label>64</label>Program in Public Health, College of Health Sciences, University of California, Irvine, Hewitt Hall, Irvine, CA 92697, USA.</aff><aff id="A65"><label>65</label>Malaria Programme, Wellcome Trust Sanger Institute, Cambridge, CB10 1SJ, UK.</aff><aff id="A66"><label>66</label>Centre of Evolutionary and Ecological Studies (CEES-MarECon group), University of Groningen, Nijenborgh 7, NL-9747 AG Groningen, The Netherlands.</aff><aff id="A67"><label>67</label>Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave, Cambridge, MA 02138, USA.</aff><aff id="A68"><label>68</label>Department of Biology, Indiana University, Bloomington, IN 47405, USA.</aff><aff id="A69"><label>69</label>Centers for Disease Control and Prevention, 1600 Clifton Road NE MSG49, Atlanta, GA 30329, USA.</aff><aff id="A70"><label>70</label>Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA.</aff><aff id="A71"><label>71</label>Laboratory of Malaria and Vector Research, NIAID, 12735 Twinbrook Parkway, Rockville MD 20852, USA.</aff><aff id="A72"><label>72</label>Departments of Biological Sciences and Pharmacology, Institutes for Chemical Biology, Genetics and Global Health, Vanderbilt University and Medical Center, Nashville, TN 37235, USA.</aff><author-notes><corresp id="cor1"><label>†</label>Corresponding author. <email>neafsey@broadinstitute.org</email> (D.E.N.); <email>nbesansk@nd.edu</email> (N.J.B.)</corresp><fn id="FN1" fn-type="equal"><label>*</label><p id="P1">These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>24</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>27</day><month>11</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>2</day><month>1</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>02</day><month>1</month><year>2016</year></pub-date><volume>347</volume><issue>6217</issue><fpage>1258522</fpage><lpage>1258522</lpage><pmc-comment>elocation-id from pubmed: 10.1126/science.1258522</pmc-comment>
<abstract><p id="P2">Variation in vectorial capacity for human malaria among <italic>Anopheles</italic> mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to <italic>Drosophila</italic>. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover, but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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