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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies<sup><xref ref-type="fn" rid="FN2">⋆</xref></sup></title><author><name sortKey="Burns, Alan J" sort="Burns, Alan J" uniqKey="Burns A" first="Alan J." last="Burns">Alan J. Burns</name><affiliation><nlm:aff id="A1">Stem Cells and Regenerative Medicine, UCL Institute of Child Health, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Goldstein, Allan M" sort="Goldstein, Allan M" uniqKey="Goldstein A" first="Allan M." last="Goldstein">Allan M. Goldstein</name><affiliation><nlm:aff id="A3">Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Newgreen, Donald F" sort="Newgreen, Donald F" uniqKey="Newgreen D" first="Donald F." last="Newgreen">Donald F. Newgreen</name><affiliation><nlm:aff id="A4">Murdoch Childrens Research Institute, Royal Children’s Hospital, Parkville 3052, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Stamp, Lincon" sort="Stamp, Lincon" uniqKey="Stamp L" first="Lincon" last="Stamp">Lincon Stamp</name><affiliation><nlm:aff id="A5">Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Sch Fer, Karl Herbert" sort="Sch Fer, Karl Herbert" uniqKey="Sch Fer K" first="Karl-Herbert" last="Sch Fer">Karl-Herbert Sch Fer</name><affiliation><nlm:aff id="A6">University of Applied Sciences, Kaiserlautern, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Clinic of Pediatric Surgery, University Hospital Mannheim, University Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Metzger, Marco" sort="Metzger, Marco" uniqKey="Metzger M" first="Marco" last="Metzger">Marco Metzger</name><affiliation><nlm:aff id="A8">Fraunhofer-Institute Interfacial Engineering and Biotechnology IGB Translational Centre – Würzburg branch and University Hospital Würzburg – Tissue Engineering and Regenerative Medicine (TERM), Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hotta, Ryo" sort="Hotta, Ryo" uniqKey="Hotta R" first="Ryo" last="Hotta">Ryo Hotta</name><affiliation><nlm:aff id="A3">Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Young, Heather M" sort="Young, Heather M" uniqKey="Young H" first="Heather M." last="Young">Heather M. Young</name><affiliation><nlm:aff id="A5">Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Andrews, Peter W" sort="Andrews, Peter W" uniqKey="Andrews P" first="Peter W." last="Andrews">Peter W. Andrews</name><affiliation><nlm:aff id="A29">Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Thapar, Nikhil" sort="Thapar, Nikhil" uniqKey="Thapar N" first="Nikhil" last="Thapar">Nikhil Thapar</name><affiliation><nlm:aff id="A1">Stem Cells and Regenerative Medicine, UCL Institute of Child Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Belkind Gerson, Jaime" sort="Belkind Gerson, Jaime" uniqKey="Belkind Gerson J" first="Jaime" last="Belkind-Gerson">Jaime Belkind-Gerson</name><affiliation><nlm:aff id="A9">Division of Gastroenterology, Hepatology and Nutrition, Massachusetts General Hospital for Children, Harvard Medical School, Boston, USA</nlm:aff></affiliation></author><author><name sortKey="Bondurand, Nadege" sort="Bondurand, Nadege" uniqKey="Bondurand N" first="Nadege" last="Bondurand">Nadege Bondurand</name><affiliation><nlm:aff id="A10">INSERM U955, 51 Avenue du Maréchal de Lattre de Tassigny, F-94000 Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Université Paris-Est, UPEC, F-94000 Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Bornstein, Joel C" sort="Bornstein, Joel C" uniqKey="Bornstein J" first="Joel C." last="Bornstein">Joel C. Bornstein</name><affiliation><nlm:aff id="A11">Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Chan, Wood Yee" sort="Chan, Wood Yee" uniqKey="Chan W" first="Wood Yee" last="Chan">Wood Yee Chan</name><affiliation><nlm:aff id="A12">School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Cheah, Kathryn" sort="Cheah, Kathryn" uniqKey="Cheah K" first="Kathryn" last="Cheah">Kathryn Cheah</name><affiliation><nlm:aff id="A13">School of Biomedical Sciences, The University of Hong Kong, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Gershon, Michael D" sort="Gershon, Michael D" uniqKey="Gershon M" first="Michael D." last="Gershon">Michael D. Gershon</name><affiliation><nlm:aff id="A14">Department of Pathology and Cell Biology, Columbia University, New York 10032, USA</nlm:aff></affiliation></author><author><name sortKey="Heuckeroth, Robert O" sort="Heuckeroth, Robert O" uniqKey="Heuckeroth R" first="Robert O." last="Heuckeroth">Robert O. Heuckeroth</name><affiliation><nlm:aff id="A15">Department of Pediatrics, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Perelman School of Medicine at the University of Pennsylvania, Abramson Research Center, Philadelphia, PA 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Hofstra, Robert M W" sort="Hofstra, Robert M W" uniqKey="Hofstra R" first="Robert M. W." last="Hofstra">Robert M. W. Hofstra</name><affiliation><nlm:aff id="A1">Stem Cells and Regenerative Medicine, UCL Institute of Child Health, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Just, Lothar" sort="Just, Lothar" uniqKey="Just L" first="Lothar" last="Just">Lothar Just</name><affiliation><nlm:aff id="A17">Institute of Clinical Anatomy and Cell Analysis, University of Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Kapur, Raj P" sort="Kapur, Raj P" uniqKey="Kapur R" first="Raj P." last="Kapur">Raj P. Kapur</name><affiliation><nlm:aff id="A18">Department of Pathology, University of Washington and Seattle Children’s Hospital, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="King, Sebastian K" sort="King, Sebastian K" uniqKey="King S" first="Sebastian K." last="King">Sebastian K. King</name><affiliation><nlm:aff id="A19">Department of Paediatric and Neonatal Surgery, The Royal Children’s Hospital, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Mccann, Conor J" sort="Mccann, Conor J" uniqKey="Mccann C" first="Conor J." last="Mccann">Conor J. Mccann</name><affiliation><nlm:aff id="A1">Stem Cells and Regenerative Medicine, UCL Institute of Child Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Nagy, Nandor" sort="Nagy, Nandor" uniqKey="Nagy N" first="Nandor" last="Nagy">Nandor Nagy</name><affiliation><nlm:aff id="A20">Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Ngan, Elly" sort="Ngan, Elly" uniqKey="Ngan E" first="Elly" last="Ngan">Elly Ngan</name><affiliation><nlm:aff id="A21">Department of Surgery, The University of Hong Kong, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Obermayr, Florian" sort="Obermayr, Florian" uniqKey="Obermayr F" first="Florian" last="Obermayr">Florian Obermayr</name><affiliation><nlm:aff id="A22">Department of Pediatric Surgery and Pediatric Urology, University Children’s Hospital Tübingen, D-72076 Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Pachnis, Vassilis" sort="Pachnis, Vassilis" uniqKey="Pachnis V" first="Vassilis" last="Pachnis">Vassilis Pachnis</name><affiliation><nlm:aff id="A23">The Francis Crick Institute, Mill Hill Laboratory, London, UK</nlm:aff></affiliation></author><author><name sortKey="Pasricha, Pankaj J" sort="Pasricha, Pankaj J" uniqKey="Pasricha P" first="Pankaj J." last="Pasricha">Pankaj J. Pasricha</name><affiliation><nlm:aff id="A24">Johns Hopkins Center for Neurogastroenterology, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Sham, Mai Har" sort="Sham, Mai Har" uniqKey="Sham M" first="Mai Har" last="Sham">Mai Har Sham</name><affiliation><nlm:aff id="A25">Department of Biochemistry, The University of Hong Kong, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Tam, Paul" sort="Tam, Paul" uniqKey="Tam P" first="Paul" last="Tam">Paul Tam</name><affiliation><nlm:aff id="A21">Department of Surgery, The University of Hong Kong, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Berghe, Pieter Vanden" sort="Berghe, Pieter Vanden" uniqKey="Berghe P" first="Pieter Vanden" last="Berghe">Pieter Vanden Berghe</name><affiliation><nlm:aff id="A26">Laboratory for Enteric NeuroScience (LENS), TARGID, University of Leuven, Belgium</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27059883</idno><idno type="pmc">5026875</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026875</idno><idno type="RBID">PMC:5026875</idno><idno type="doi">10.1016/j.ydbio.2016.04.001</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001D02</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D02</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies<sup><xref ref-type="fn" rid="FN2">⋆</xref></sup></title><author><name sortKey="Burns, Alan J" sort="Burns, Alan J" uniqKey="Burns A" first="Alan J." last="Burns">Alan J. Burns</name><affiliation><nlm:aff id="A1">Stem Cells and Regenerative Medicine, UCL Institute of Child Health, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Goldstein, Allan M" sort="Goldstein, Allan M" uniqKey="Goldstein A" first="Allan M." last="Goldstein">Allan M. Goldstein</name><affiliation><nlm:aff id="A3">Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Newgreen, Donald F" sort="Newgreen, Donald F" uniqKey="Newgreen D" first="Donald F." last="Newgreen">Donald F. Newgreen</name><affiliation><nlm:aff id="A4">Murdoch Childrens Research Institute, Royal Children’s Hospital, Parkville 3052, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Stamp, Lincon" sort="Stamp, Lincon" uniqKey="Stamp L" first="Lincon" last="Stamp">Lincon Stamp</name><affiliation><nlm:aff id="A5">Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Sch Fer, Karl Herbert" sort="Sch Fer, Karl Herbert" uniqKey="Sch Fer K" first="Karl-Herbert" last="Sch Fer">Karl-Herbert Sch Fer</name><affiliation><nlm:aff id="A6">University of Applied Sciences, Kaiserlautern, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Clinic of Pediatric Surgery, University Hospital Mannheim, University Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Metzger, Marco" sort="Metzger, Marco" uniqKey="Metzger M" first="Marco" last="Metzger">Marco Metzger</name><affiliation><nlm:aff id="A8">Fraunhofer-Institute Interfacial Engineering and Biotechnology IGB Translational Centre – Würzburg branch and University Hospital Würzburg – Tissue Engineering and Regenerative Medicine (TERM), Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hotta, Ryo" sort="Hotta, Ryo" uniqKey="Hotta R" first="Ryo" last="Hotta">Ryo Hotta</name><affiliation><nlm:aff id="A3">Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Young, Heather M" sort="Young, Heather M" uniqKey="Young H" first="Heather M." last="Young">Heather M. Young</name><affiliation><nlm:aff id="A5">Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Andrews, Peter W" sort="Andrews, Peter W" uniqKey="Andrews P" first="Peter W." last="Andrews">Peter W. Andrews</name><affiliation><nlm:aff id="A29">Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Thapar, Nikhil" sort="Thapar, Nikhil" uniqKey="Thapar N" first="Nikhil" last="Thapar">Nikhil Thapar</name><affiliation><nlm:aff id="A1">Stem Cells and Regenerative Medicine, UCL Institute of Child Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Belkind Gerson, Jaime" sort="Belkind Gerson, Jaime" uniqKey="Belkind Gerson J" first="Jaime" last="Belkind-Gerson">Jaime Belkind-Gerson</name><affiliation><nlm:aff id="A9">Division of Gastroenterology, Hepatology and Nutrition, Massachusetts General Hospital for Children, Harvard Medical School, Boston, USA</nlm:aff></affiliation></author><author><name sortKey="Bondurand, Nadege" sort="Bondurand, Nadege" uniqKey="Bondurand N" first="Nadege" last="Bondurand">Nadege Bondurand</name><affiliation><nlm:aff id="A10">INSERM U955, 51 Avenue du Maréchal de Lattre de Tassigny, F-94000 Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Université Paris-Est, UPEC, F-94000 Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Bornstein, Joel C" sort="Bornstein, Joel C" uniqKey="Bornstein J" first="Joel C." last="Bornstein">Joel C. Bornstein</name><affiliation><nlm:aff id="A11">Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia</nlm:aff></affiliation></author><author><name sortKey="Chan, Wood Yee" sort="Chan, Wood Yee" uniqKey="Chan W" first="Wood Yee" last="Chan">Wood Yee Chan</name><affiliation><nlm:aff id="A12">School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Cheah, Kathryn" sort="Cheah, Kathryn" uniqKey="Cheah K" first="Kathryn" last="Cheah">Kathryn Cheah</name><affiliation><nlm:aff id="A13">School of Biomedical Sciences, The University of Hong Kong, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Gershon, Michael D" sort="Gershon, Michael D" uniqKey="Gershon M" first="Michael D." last="Gershon">Michael D. Gershon</name><affiliation><nlm:aff id="A14">Department of Pathology and Cell Biology, Columbia University, New York 10032, USA</nlm:aff></affiliation></author><author><name sortKey="Heuckeroth, Robert O" sort="Heuckeroth, Robert O" uniqKey="Heuckeroth R" first="Robert O." last="Heuckeroth">Robert O. Heuckeroth</name><affiliation><nlm:aff id="A15">Department of Pediatrics, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Perelman School of Medicine at the University of Pennsylvania, Abramson Research Center, Philadelphia, PA 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Hofstra, Robert M W" sort="Hofstra, Robert M W" uniqKey="Hofstra R" first="Robert M. W." last="Hofstra">Robert M. W. Hofstra</name><affiliation><nlm:aff id="A1">Stem Cells and Regenerative Medicine, UCL Institute of Child Health, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Just, Lothar" sort="Just, Lothar" uniqKey="Just L" first="Lothar" last="Just">Lothar Just</name><affiliation><nlm:aff id="A17">Institute of Clinical Anatomy and Cell Analysis, University of Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Kapur, Raj P" sort="Kapur, Raj P" uniqKey="Kapur R" first="Raj P." last="Kapur">Raj P. Kapur</name><affiliation><nlm:aff id="A18">Department of Pathology, University of Washington and Seattle Children’s Hospital, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="King, Sebastian K" sort="King, Sebastian K" uniqKey="King S" first="Sebastian K." last="King">Sebastian K. King</name><affiliation><nlm:aff id="A19">Department of Paediatric and Neonatal Surgery, The Royal Children’s Hospital, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Mccann, Conor J" sort="Mccann, Conor J" uniqKey="Mccann C" first="Conor J." last="Mccann">Conor J. Mccann</name><affiliation><nlm:aff id="A1">Stem Cells and Regenerative Medicine, UCL Institute of Child Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Nagy, Nandor" sort="Nagy, Nandor" uniqKey="Nagy N" first="Nandor" last="Nagy">Nandor Nagy</name><affiliation><nlm:aff id="A20">Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Ngan, Elly" sort="Ngan, Elly" uniqKey="Ngan E" first="Elly" last="Ngan">Elly Ngan</name><affiliation><nlm:aff id="A21">Department of Surgery, The University of Hong Kong, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Obermayr, Florian" sort="Obermayr, Florian" uniqKey="Obermayr F" first="Florian" last="Obermayr">Florian Obermayr</name><affiliation><nlm:aff id="A22">Department of Pediatric Surgery and Pediatric Urology, University Children’s Hospital Tübingen, D-72076 Tübingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Pachnis, Vassilis" sort="Pachnis, Vassilis" uniqKey="Pachnis V" first="Vassilis" last="Pachnis">Vassilis Pachnis</name><affiliation><nlm:aff id="A23">The Francis Crick Institute, Mill Hill Laboratory, London, UK</nlm:aff></affiliation></author><author><name sortKey="Pasricha, Pankaj J" sort="Pasricha, Pankaj J" uniqKey="Pasricha P" first="Pankaj J." last="Pasricha">Pankaj J. Pasricha</name><affiliation><nlm:aff id="A24">Johns Hopkins Center for Neurogastroenterology, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Sham, Mai Har" sort="Sham, Mai Har" uniqKey="Sham M" first="Mai Har" last="Sham">Mai Har Sham</name><affiliation><nlm:aff id="A25">Department of Biochemistry, The University of Hong Kong, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Tam, Paul" sort="Tam, Paul" uniqKey="Tam P" first="Paul" last="Tam">Paul Tam</name><affiliation><nlm:aff id="A21">Department of Surgery, The University of Hong Kong, Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Berghe, Pieter Vanden" sort="Berghe, Pieter Vanden" uniqKey="Berghe P" first="Pieter Vanden" last="Berghe">Pieter Vanden Berghe</name><affiliation><nlm:aff id="A26">Laboratory for Enteric NeuroScience (LENS), TARGID, University of Leuven, Belgium</nlm:aff></affiliation></author></analytic><series><title level="j">Developmental biology</title><idno type="ISSN">0012-1606</idno><idno type="eISSN">1095-564X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts’ views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0372762</journal-id><journal-id journal-id-type="pubmed-jr-id">3389</journal-id><journal-id journal-id-type="nlm-ta">Dev Biol</journal-id><journal-id journal-id-type="iso-abbrev">Dev. Biol.</journal-id><journal-title-group><journal-title>Developmental biology</journal-title></journal-title-group><issn pub-type="ppub">0012-1606</issn><issn pub-type="epub">1095-564X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27059883</article-id><article-id pub-id-type="pmc">5026875</article-id><article-id pub-id-type="doi">10.1016/j.ydbio.2016.04.001</article-id><article-id pub-id-type="manuscript">NIHMS791858</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies<sup><xref ref-type="fn" rid="FN2">⋆</xref></sup></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Burns</surname><given-names>Alan J.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Goldstein</surname><given-names>Allan M.</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Newgreen</surname><given-names>Donald F.</given-names></name><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Stamp</surname><given-names>Lincon</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Schäfer</surname><given-names>Karl-Herbert</given-names></name><xref ref-type="aff" rid="A6">f</xref><xref ref-type="aff" rid="A7">g</xref></contrib><contrib contrib-type="author"><name><surname>Metzger</surname><given-names>Marco</given-names></name><xref ref-type="aff" rid="A8">h</xref></contrib><contrib contrib-type="author"><name><surname>Hotta</surname><given-names>Ryo</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Young</surname><given-names>Heather M.</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Andrews</surname><given-names>Peter W.</given-names></name><xref ref-type="aff" rid="A29">ac</xref></contrib><contrib contrib-type="author"><name><surname>Thapar</surname><given-names>Nikhil</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Belkind-Gerson</surname><given-names>Jaime</given-names></name><xref ref-type="aff" rid="A9">i</xref></contrib><contrib contrib-type="author"><name><surname>Bondurand</surname><given-names>Nadege</given-names></name><xref ref-type="aff" rid="A10">j</xref><xref ref-type="aff" rid="A27">aa</xref></contrib><contrib contrib-type="author"><name><surname>Bornstein</surname><given-names>Joel C.</given-names></name><xref ref-type="aff" rid="A11">k</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Wood Yee</given-names></name><xref ref-type="aff" rid="A12">l</xref></contrib><contrib contrib-type="author"><name><surname>Cheah</surname><given-names>Kathryn</given-names></name><xref ref-type="aff" rid="A13">m</xref></contrib><contrib contrib-type="author"><name><surname>Gershon</surname><given-names>Michael D.</given-names></name><xref ref-type="aff" rid="A14">n</xref></contrib><contrib contrib-type="author"><name><surname>Heuckeroth</surname><given-names>Robert O.</given-names></name><xref ref-type="aff" rid="A15">o</xref><xref ref-type="aff" rid="A28">ab</xref></contrib><contrib contrib-type="author"><name><surname>Hofstra</surname><given-names>Robert M.W.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A16">p</xref></contrib><contrib contrib-type="author"><name><surname>Just</surname><given-names>Lothar</given-names></name><xref ref-type="aff" rid="A17">q</xref></contrib><contrib contrib-type="author"><name><surname>Kapur</surname><given-names>Raj P.</given-names></name><xref ref-type="aff" rid="A18">r</xref></contrib><contrib contrib-type="author"><name><surname>King</surname><given-names>Sebastian K.</given-names></name><xref ref-type="aff" rid="A19">s</xref></contrib><contrib contrib-type="author"><name><surname>McCann</surname><given-names>Conor J.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Nagy</surname><given-names>Nandor</given-names></name><xref ref-type="aff" rid="A20">t</xref></contrib><contrib contrib-type="author"><name><surname>Ngan</surname><given-names>Elly</given-names></name><xref ref-type="aff" rid="A21">u</xref></contrib><contrib contrib-type="author"><name><surname>Obermayr</surname><given-names>Florian</given-names></name><xref ref-type="aff" rid="A22">v</xref></contrib><contrib contrib-type="author"><name><surname>Pachnis</surname><given-names>Vassilis</given-names></name><xref ref-type="aff" rid="A23">w</xref></contrib><contrib contrib-type="author"><name><surname>Pasricha</surname><given-names>Pankaj J.</given-names></name><xref ref-type="aff" rid="A24">x</xref></contrib><contrib contrib-type="author"><name><surname>Sham</surname><given-names>Mai Har</given-names></name><xref ref-type="aff" rid="A25">y</xref></contrib><contrib contrib-type="author"><name><surname>Tam</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="A21">u</xref></contrib><contrib contrib-type="author"><name><surname>Berghe</surname><given-names>Pieter Vanden</given-names></name><xref ref-type="aff" rid="A26">z</xref></contrib></contrib-group><aff id="A1"><label>a</label>Stem Cells and Regenerative Medicine, UCL Institute of Child Health, London, UK</aff><aff id="A2"><label>b</label>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A3"><label>c</label>Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</aff><aff id="A4"><label>d</label>Murdoch Childrens Research Institute, Royal Children’s Hospital, Parkville 3052, Victoria, Australia</aff><aff id="A5"><label>e</label>Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia</aff><aff id="A6"><label>f</label>University of Applied Sciences, Kaiserlautern, Germany</aff><aff id="A7"><label>g</label>Clinic of Pediatric Surgery, University Hospital Mannheim, University Heidelberg, Germany</aff><aff id="A8"><label>h</label>Fraunhofer-Institute Interfacial Engineering and Biotechnology IGB Translational Centre – Würzburg branch and University Hospital Würzburg – Tissue Engineering and Regenerative Medicine (TERM), Würzburg, Germany</aff><aff id="A9"><label>i</label>Division of Gastroenterology, Hepatology and Nutrition, Massachusetts General Hospital for Children, Harvard Medical School, Boston, USA</aff><aff id="A10"><label>j</label>INSERM U955, 51 Avenue du Maréchal de Lattre de Tassigny, F-94000 Créteil, France</aff><aff id="A11"><label>k</label>Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia</aff><aff id="A12"><label>l</label>School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong</aff><aff id="A13"><label>m</label>School of Biomedical Sciences, The University of Hong Kong, Hong Kong</aff><aff id="A14"><label>n</label>Department of Pathology and Cell Biology, Columbia University, New York 10032, USA</aff><aff id="A15"><label>o</label>Department of Pediatrics, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA</aff><aff id="A16"><label>p</label>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A17"><label>q</label>Institute of Clinical Anatomy and Cell Analysis, University of Tübingen, Germany</aff><aff id="A18"><label>r</label>Department of Pathology, University of Washington and Seattle Children’s Hospital, Seattle, WA, USA</aff><aff id="A19"><label>s</label>Department of Paediatric and Neonatal Surgery, The Royal Children’s Hospital, Melbourne, Australia</aff><aff id="A20"><label>t</label>Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, Hungary</aff><aff id="A21"><label>u</label>Department of Surgery, The University of Hong Kong, Hong Kong</aff><aff id="A22"><label>v</label>Department of Pediatric Surgery and Pediatric Urology, University Children’s Hospital Tübingen, D-72076 Tübingen, Germany</aff><aff id="A23"><label>w</label>The Francis Crick Institute, Mill Hill Laboratory, London, UK</aff><aff id="A24"><label>x</label>Johns Hopkins Center for Neurogastroenterology, Baltimore, MD, USA</aff><aff id="A25"><label>y</label>Department of Biochemistry, The University of Hong Kong, Hong Kong</aff><aff id="A26"><label>z</label>Laboratory for Enteric NeuroScience (LENS), TARGID, University of Leuven, Belgium</aff><aff id="A27"><label>aa</label>Université Paris-Est, UPEC, F-94000 Créteil, France</aff><aff id="A28"><label>ab</label>Perelman School of Medicine at the University of Pennsylvania, Abramson Research Center, Philadelphia, PA 19104, USA</aff><aff id="A29"><label>ac</label>Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Sheffield, UK</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author at: Stem Cells and Regenerative Medicine, Birth Defects Research Centre, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. <email>alan.burns@ucl.ac.uk</email> (A.J. Burns)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>8</day><month>6</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>5</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>9</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>17</day><month>9</month><year>2016</year></pub-date><volume>417</volume><issue>2</issue><fpage>229</fpage><lpage>251</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.ydbio.2016.04.001</pmc-comment>
<abstract><p id="P1">Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts’ views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.</p></abstract><kwd-group><kwd>Enteric nervous system</kwd><kwd>Enteric neuropathies</kwd><kwd>Stem cells</kwd><kwd>Cell replacement therapy</kwd><kwd>Hirschsprung disease</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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