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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinemia: A Task Force from the 8<sup>th</sup> International Workshop on Waldenström Macroglobulinemia</title><author><name sortKey="Castillo, Jorge J" sort="Castillo, Jorge J" uniqKey="Castillo J" first="Jorge J." last="Castillo">Jorge J. Castillo</name><affiliation><nlm:aff id="A1">Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Garcia Sanz, Ramon" sort="Garcia Sanz, Ramon" uniqKey="Garcia Sanz R" first="Ramon" last="Garcia-Sanz">Ramon Garcia-Sanz</name><affiliation><nlm:aff id="A2">Hospital Universitario de Salamanca, Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Hatjiharissi, Evdoxia" sort="Hatjiharissi, Evdoxia" uniqKey="Hatjiharissi E" first="Evdoxia" last="Hatjiharissi">Evdoxia Hatjiharissi</name><affiliation><nlm:aff id="A3">Department of Hematology, Theageneion Hospital of Thessaloniki, Thessaloniki, Greece</nlm:aff></affiliation></author><author><name sortKey="Kyle, Robert" sort="Kyle, Robert" uniqKey="Kyle R" first="Robert" last="Kyle">Robert Kyle</name><affiliation><nlm:aff id="A4">Division of Hematology, Mayo Clinic, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Leleu, Xavier" sort="Leleu, Xavier" uniqKey="Leleu X" first="Xavier" last="Leleu">Xavier Leleu</name><affiliation><nlm:aff id="A5">La Miletrie Hospital, CHU Poitiers, Poitiers, France</nlm:aff></affiliation></author><author><name sortKey="Mcmaster, Mary L" sort="Mcmaster, Mary L" uniqKey="Mcmaster M" first="Mary L." last="Mcmaster">Mary L. Mcmaster</name><affiliation><nlm:aff id="A6">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Merlini, Giampaolo" sort="Merlini, Giampaolo" uniqKey="Merlini G" first="Giampaolo" last="Merlini">Giampaolo Merlini</name><affiliation><nlm:aff id="A7">Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy</nlm:aff></affiliation></author><author><name sortKey="Minnema, Monique C" sort="Minnema, Monique C" uniqKey="Minnema M" first="Monique C." last="Minnema">Monique C. Minnema</name><affiliation><nlm:aff id="A8">University Medical Centre Utrecht, Utrecht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Morra, Enrica" sort="Morra, Enrica" uniqKey="Morra E" first="Enrica" last="Morra">Enrica Morra</name><affiliation><nlm:aff id="A9">Division of Hematology, Niguarda Ca’ Granda Hospital, Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Owen, Roger" sort="Owen, Roger" uniqKey="Owen R" first="Roger" last="Owen">Roger Owen</name><affiliation><nlm:aff id="A10">St James’s Institute of Oncology, Leeds Teaching Hospitals NHS Trust, Leeds, UK</nlm:aff></affiliation></author><author><name sortKey="Poulain, Stephanie" sort="Poulain, Stephanie" uniqKey="Poulain S" first="Stephanie" last="Poulain">Stephanie Poulain</name><affiliation><nlm:aff id="A11">Service d’Hématologie-Immunologie-Cytogénétique, Centre Hospitalier de Valenciennes, France</nlm:aff></affiliation></author><author><name sortKey="Stone, Marvin" sort="Stone, Marvin" uniqKey="Stone M" first="Marvin" last="Stone">Marvin Stone</name><affiliation><nlm:aff id="A12">Department of Oncology, Baylor Charles A Sammons Cancer Center, Dallas, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Tam, Constantine" sort="Tam, Constantine" uniqKey="Tam C" first="Constantine" last="Tam">Constantine Tam</name><affiliation><nlm:aff id="A13">Department of Haematology, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Varettoni, Marzia" sort="Varettoni, Marzia" uniqKey="Varettoni M" first="Marzia" last="Varettoni">Marzia Varettoni</name><affiliation><nlm:aff id="A14">Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy</nlm:aff></affiliation></author><author><name sortKey="Dimopoulos, Meletios" sort="Dimopoulos, Meletios" uniqKey="Dimopoulos M" first="Meletios" last="Dimopoulos">Meletios Dimopoulos</name><affiliation><nlm:aff id="A15">Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Treon, Steven P" sort="Treon, Steven P" uniqKey="Treon S" first="Steven P." last="Treon">Steven P. Treon</name><affiliation><nlm:aff id="A1">Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Kastritis, Efstathios" sort="Kastritis, Efstathios" uniqKey="Kastritis E" first="Efstathios" last="Kastritis">Efstathios Kastritis</name><affiliation><nlm:aff id="A15">Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27378193</idno><idno type="pmc">5154335</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154335</idno><idno type="RBID">PMC:5154335</idno><idno type="doi">10.1111/bjh.14196</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001D00</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinemia: A Task Force from the 8<sup>th</sup> International Workshop on Waldenström Macroglobulinemia</title><author><name sortKey="Castillo, Jorge J" sort="Castillo, Jorge J" uniqKey="Castillo J" first="Jorge J." last="Castillo">Jorge J. Castillo</name><affiliation><nlm:aff id="A1">Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Garcia Sanz, Ramon" sort="Garcia Sanz, Ramon" uniqKey="Garcia Sanz R" first="Ramon" last="Garcia-Sanz">Ramon Garcia-Sanz</name><affiliation><nlm:aff id="A2">Hospital Universitario de Salamanca, Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Hatjiharissi, Evdoxia" sort="Hatjiharissi, Evdoxia" uniqKey="Hatjiharissi E" first="Evdoxia" last="Hatjiharissi">Evdoxia Hatjiharissi</name><affiliation><nlm:aff id="A3">Department of Hematology, Theageneion Hospital of Thessaloniki, Thessaloniki, Greece</nlm:aff></affiliation></author><author><name sortKey="Kyle, Robert" sort="Kyle, Robert" uniqKey="Kyle R" first="Robert" last="Kyle">Robert Kyle</name><affiliation><nlm:aff id="A4">Division of Hematology, Mayo Clinic, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Leleu, Xavier" sort="Leleu, Xavier" uniqKey="Leleu X" first="Xavier" last="Leleu">Xavier Leleu</name><affiliation><nlm:aff id="A5">La Miletrie Hospital, CHU Poitiers, Poitiers, France</nlm:aff></affiliation></author><author><name sortKey="Mcmaster, Mary L" sort="Mcmaster, Mary L" uniqKey="Mcmaster M" first="Mary L." last="Mcmaster">Mary L. Mcmaster</name><affiliation><nlm:aff id="A6">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Merlini, Giampaolo" sort="Merlini, Giampaolo" uniqKey="Merlini G" first="Giampaolo" last="Merlini">Giampaolo Merlini</name><affiliation><nlm:aff id="A7">Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy</nlm:aff></affiliation></author><author><name sortKey="Minnema, Monique C" sort="Minnema, Monique C" uniqKey="Minnema M" first="Monique C." last="Minnema">Monique C. Minnema</name><affiliation><nlm:aff id="A8">University Medical Centre Utrecht, Utrecht, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Morra, Enrica" sort="Morra, Enrica" uniqKey="Morra E" first="Enrica" last="Morra">Enrica Morra</name><affiliation><nlm:aff id="A9">Division of Hematology, Niguarda Ca’ Granda Hospital, Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Owen, Roger" sort="Owen, Roger" uniqKey="Owen R" first="Roger" last="Owen">Roger Owen</name><affiliation><nlm:aff id="A10">St James’s Institute of Oncology, Leeds Teaching Hospitals NHS Trust, Leeds, UK</nlm:aff></affiliation></author><author><name sortKey="Poulain, Stephanie" sort="Poulain, Stephanie" uniqKey="Poulain S" first="Stephanie" last="Poulain">Stephanie Poulain</name><affiliation><nlm:aff id="A11">Service d’Hématologie-Immunologie-Cytogénétique, Centre Hospitalier de Valenciennes, France</nlm:aff></affiliation></author><author><name sortKey="Stone, Marvin" sort="Stone, Marvin" uniqKey="Stone M" first="Marvin" last="Stone">Marvin Stone</name><affiliation><nlm:aff id="A12">Department of Oncology, Baylor Charles A Sammons Cancer Center, Dallas, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Tam, Constantine" sort="Tam, Constantine" uniqKey="Tam C" first="Constantine" last="Tam">Constantine Tam</name><affiliation><nlm:aff id="A13">Department of Haematology, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Varettoni, Marzia" sort="Varettoni, Marzia" uniqKey="Varettoni M" first="Marzia" last="Varettoni">Marzia Varettoni</name><affiliation><nlm:aff id="A14">Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy</nlm:aff></affiliation></author><author><name sortKey="Dimopoulos, Meletios" sort="Dimopoulos, Meletios" uniqKey="Dimopoulos M" first="Meletios" last="Dimopoulos">Meletios Dimopoulos</name><affiliation><nlm:aff id="A15">Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Treon, Steven P" sort="Treon, Steven P" uniqKey="Treon S" first="Steven P." last="Treon">Steven P. Treon</name><affiliation><nlm:aff id="A1">Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Kastritis, Efstathios" sort="Kastritis, Efstathios" uniqKey="Kastritis E" first="Efstathios" last="Kastritis">Efstathios Kastritis</name><affiliation><nlm:aff id="A15">Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece</nlm:aff></affiliation></author></analytic><series><title level="j">British journal of haematology</title><idno type="ISSN">0007-1048</idno><idno type="eISSN">1365-2141</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The diagnosis of Waldenström macroglobulinemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop consensus recommendations for the diagnosis and initial evaluation of patients with WM. In this document, we present the results of the deliberations taken place to address these issues. We provide recommendations for history taking and physical examination, laboratory studies, bone marrow aspiration and biopsy analysis and imaging studies. We also provide guidance on the initial evaluation of special situations such as anemia, hyperviscosity, neuropathy, Bing-Neel syndrome and amyloidosis. We hope these recommendations serve as a practical guidance to clinicians taking care of patients with a suspected or an established diagnosis of WM.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0372544</journal-id><journal-id journal-id-type="pubmed-jr-id">1822</journal-id><journal-id journal-id-type="nlm-ta">Br J Haematol</journal-id><journal-id journal-id-type="iso-abbrev">Br. J. Haematol.</journal-id><journal-title-group><journal-title>British journal of haematology</journal-title></journal-title-group><issn pub-type="ppub">0007-1048</issn><issn pub-type="epub">1365-2141</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27378193</article-id><article-id pub-id-type="pmc">5154335</article-id><article-id pub-id-type="doi">10.1111/bjh.14196</article-id><article-id pub-id-type="manuscript">NIHMS833369</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinemia: A Task Force from the 8<sup>th</sup> International Workshop on Waldenström Macroglobulinemia</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Castillo</surname><given-names>Jorge J.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Garcia-Sanz</surname><given-names>Ramon</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hatjiharissi</surname><given-names>Evdoxia</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Kyle</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Leleu</surname><given-names>Xavier</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>McMaster</surname><given-names>Mary L.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Merlini</surname><given-names>Giampaolo</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Minnema</surname><given-names>Monique C.</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Morra</surname><given-names>Enrica</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Owen</surname><given-names>Roger</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Poulain</surname><given-names>Stephanie</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Stone</surname><given-names>Marvin</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Tam</surname><given-names>Constantine</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Varettoni</surname><given-names>Marzia</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Dimopoulos</surname><given-names>Meletios</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Treon</surname><given-names>Steven P.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kastritis</surname><given-names>Efstathios</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib></contrib-group><aff id="A1"><label>1</label>Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA</aff><aff id="A2"><label>2</label>Hospital Universitario de Salamanca, Salamanca, Spain</aff><aff id="A3"><label>3</label>Department of Hematology, Theageneion Hospital of Thessaloniki, Thessaloniki, Greece</aff><aff id="A4"><label>4</label>Division of Hematology, Mayo Clinic, Rochester, Minnesota</aff><aff id="A5"><label>5</label>La Miletrie Hospital, CHU Poitiers, Poitiers, France</aff><aff id="A6"><label>6</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</aff><aff id="A7"><label>7</label>Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy</aff><aff id="A8"><label>8</label>University Medical Centre Utrecht, Utrecht, the Netherlands</aff><aff id="A9"><label>9</label>Division of Hematology, Niguarda Ca’ Granda Hospital, Milano, Italy</aff><aff id="A10"><label>10</label>St James’s Institute of Oncology, Leeds Teaching Hospitals NHS Trust, Leeds, UK</aff><aff id="A11"><label>11</label>Service d’Hématologie-Immunologie-Cytogénétique, Centre Hospitalier de Valenciennes, France</aff><aff id="A12"><label>12</label>Department of Oncology, Baylor Charles A Sammons Cancer Center, Dallas, TX, USA</aff><aff id="A13"><label>13</label>Department of Haematology, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Australia</aff><aff id="A14"><label>14</label>Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy</aff><aff id="A15"><label>15</label>Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece</aff><author-notes><corresp id="cor1"><bold>Corresponding author:</bold> Jorge J. Castillo, MD, 450 Brookline Ave, M221, Boston, MA 02215, Phone: 617-632-6045, Fax: 617-632-4862, <email>jorgej_castillo@dfci.harvard.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>3</day><month>12</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>05</day><month>7</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>13</day><month>12</month><year>2016</year></pub-date><volume>175</volume><issue>1</issue><fpage>77</fpage><lpage>86</lpage><pmc-comment>elocation-id from pubmed: 10.1111/bjh.14196</pmc-comment>
<abstract><p id="P1">The diagnosis of Waldenström macroglobulinemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop consensus recommendations for the diagnosis and initial evaluation of patients with WM. In this document, we present the results of the deliberations taken place to address these issues. We provide recommendations for history taking and physical examination, laboratory studies, bone marrow aspiration and biopsy analysis and imaging studies. We also provide guidance on the initial evaluation of special situations such as anemia, hyperviscosity, neuropathy, Bing-Neel syndrome and amyloidosis. We hope these recommendations serve as a practical guidance to clinicians taking care of patients with a suspected or an established diagnosis of WM.</p></abstract><kwd-group><kwd>Waldenström macroglobulinemia</kwd><kwd>anemia</kwd><kwd>neuropathy</kwd><kwd>hyperviscosity</kwd><kwd>Bing-Neel syndrome</kwd><kwd>amyloidosis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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